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2. Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine

Author

Cotero, Victoria, Graf, John, Miwa, Hiromi, Hirschstein, Zall, Qanud, Khaled, Huerta, Tomás S, Tai, Ningwen, Ding, Yuyan, Jimenez-Cowell, Kevin, Tomaio, Jacquelyn N, Song, Weiguo, Devarajan, Alex, Tsaava, Tea, Madhavan, Radhika, Wallace, Kirk, Loghin, Evelina, Morton, Christine, Fan, Ying, Kao, Tzu-Jen, Akhtar, Kainat, Damaraju, Meghana, Barenboim, Linda, Maietta, Teresa, Ashe, Jeffrey, Tracey, Kevin J, Coleman, Thomas R, Di Carlo, Dino, Shin, Damian, Zanos, Stavros, Chavan, Sangeeta S, Herzog, Raimund I, and Puleo, Chris

Subjects
Engineering, Biomedical Engineering, Nutrition, Neurosciences, Diabetes, Digestive Diseases, Liver Disease, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Animals, Diabetes Mellitus, Experimental, Glucose, Homeostasis, Hypothalamus, Liver, Mice, Rats, Swine, Biomedical engineering
Abstract

Peripheral neurons that sense glucose relay signals of glucose availability to integrative clusters of neurons in the brain. However, the roles of such signalling pathways in the maintenance of glucose homoeostasis and their contribution to disease are unknown. Here we show that the selective activation of the nerve plexus of the hepatic portal system via peripheral focused ultrasound stimulation (pFUS) improves glucose homoeostasis in mice and rats with insulin-resistant diabetes and in swine subject to hyperinsulinemic-euglycaemic clamps. pFUS modulated the activity of sensory projections to the hypothalamus, altered the concentrations of metabolism-regulating neurotransmitters, and enhanced glucose tolerance and utilization in the three species, whereas physical transection or chemical blocking of the liver-brain nerve pathway abolished the effect of pFUS on glucose tolerance. Longitudinal multi-omic profiling of metabolic tissues from the treated animals confirmed pFUS-induced modifications of key metabolic functions in liver, pancreas, muscle, adipose, kidney and intestinal tissues. Non-invasive ultrasound activation of afferent autonomic nerves may represent a non-pharmacologic therapy for the restoration of glucose homoeostasis in type-2 diabetes and other metabolic diseases.

Published
2022

4. Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats

Author

Herlihy, Rachael A., primary, Alicandri, Francisco, additional, Berger, Hudy, additional, Rehman, Huda, additional, Kao, Yifan, additional, Akhtar, Kainat, additional, Dybas, Elizabeth, additional, Mahoney-Rafferty, Emily, additional, Von Stein, Kassie, additional, Kirby, Raven, additional, Tawfik, Angela, additional, Skumurski, Rachel, additional, Feustel, Paul J., additional, Molho, Eric S., additional, and Shin, Damian S., additional

Published
2023
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5. Focused Ultrasound Modulation of Hepatic Neural Plexus Restores Glucose Homeostasis in Diabetes

Author

Cotero, Victoria, primary, Miwa, Hiromi, additional, Hirschstein, Zall, additional, Qanud, Khaled, additional, Huerta, Tomás S., additional, Tai, Ningwen, additional, Ding, Yuyan, additional, Jimenez-Cowell, Kevin, additional, Tomaio, Jacquelyn-Nicole, additional, Song, Weiguo, additional, Devarajan, Alex, additional, Tsaava, Tea, additional, Graf, John, additional, Madhavan, Radhika, additional, Wallace, Kirk, additional, Loghin, Evelina, additional, Morton, Christine, additional, Fan, Ying, additional, Kao, Tzu-Jen, additional, Akhtar, Kainat, additional, Damaraju, Meghana, additional, Barenboim, Linda, additional, Maietta, Teresa, additional, Ashe, Jeffrey, additional, Tracey, Kevin J., additional, Coleman, Thomas R., additional, Carlo, Dino Di, additional, Shin, Damian, additional, Zanos, Stavros, additional, Chavan, Sangeeta S., additional, Herzog, Raimund I., additional, and Puleo, Chris, additional

Published
2021
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6. Motor Thalamic Deep Brain Stimulation Alters Cortical Activity and Shows Therapeutic Utility for Treatment of Parkinson’s Disease Symptoms in a Rat Model

Author

Tucker, Heidi R., primary, Mahoney, Emily, additional, Akhtar, Kainat, additional, Kao, Tzu-Jen, additional, Mamone, Gianna, additional, Mikkilineni, Saisree, additional, Ravi, Maya, additional, Watkins, Hanel, additional, Terrelonge, Danielle-Lee, additional, Martin, Caryn, additional, Unger, Kristen, additional, Kim, Gabrielle, additional, Fiber, Kyra, additional, Gupta, Megan, additional, Indajang, Jonathan, additional, Kochman, Eliyahu M., additional, Sachs, Natasha, additional, Feustel, Paul, additional, Molho, Eric S., additional, Pilitsis, Julie G., additional, and Shin, Damian S., additional

Published
2021
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7. Non‐invasive peripheral focused ultrasound neuromodulation of the celiac plexus ameliorates symptoms in a rat model of inflammatory bowel disease

Author

Akhtar, Kainat, primary, Hirschstein, Zall, additional, Stefanelli, Allison, additional, Iannilli, Emilia, additional, Srinivasan, Aditya, additional, Barenboim, Linda, additional, Balkaya, Mustafa, additional, Cunha, Alexandra, additional, Audil, Aliyah, additional, Kochman, Eliyahu M., additional, Chua, Fuyee, additional, Ravi, Maya, additional, Mikkilineni, Saisree, additional, Watkins, Hanel, additional, O'Connor, William, additional, Fan, Ying, additional, Cotero, Victoria, additional, Ashe, Jeffrey, additional, Puleo, Christopher, additional, Kao, Tzu‐Jen, additional, and Shin, Damian S., additional

Published
2021
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8. Effects of subthalamic nucleus deep brain stimulation on neuronal spiking activity in the substantia nigra pars compacta in a rat model of Parkinson’s disease

Author

Sahai, Siddhartha, primary, Effendi, Emaan T., additional, Mahoney, Emily C., additional, Tucker, Heidi R., additional, Moolick, Benjamin J., additional, Mamone, Gianna, additional, Mikkilineni, Saisree, additional, Gupta, Megan, additional, Nicholson, Alycia, additional, Chua, Fu Yee, additional, Akhtar, Kainat, additional, Hirschstein, Zall, additional, Molho, Eric S., additional, Pilitsis, Julie G., additional, and Shin, Damian S., additional

Published
2020
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