16 results on '"Akhoundi FH"'
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2. Acute cerebellitis following COVID-19 vaccination: A case report.
- Author
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Tabatabaee S, Akhoundi FH, Khobeydeh A, Tabatabaei SM, and Haghi Ashtiani B
- Abstract
A plethora of neurological symptoms have been reported as the side effects of COVID-19 vaccines. Vaccine-associated acute cerebellitis is quite rare. Here, we report a 45-year-old female with acute onset cerebellitis, beginning 10 days after administration of Sinopharm vaccine. The patient's CSF COVID-19 PCR was found to be positive, with no pulmonary symptoms., (© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
- Published
- 2023
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3. Posterior reversible encephalopathy syndrome in SARS-CoV-2 infection: A case report and review of literature.
- Author
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Ziaee M, Saeedi M, Rohani M, Mehrpour M, Haghi Ashtiani B, Zamani B, Akhoundi FH, Salahi Khalaf M, Mirmoeeni S, Azari Jafari A, and Shateri Z
- Abstract
Consider PRES in SARS-CoV-2 infected patients who develop encephalopathy, seizures or impaired vision; especially if the disease is complicated by respiratory distress and need for mechanical ventilation., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
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- 2023
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4. A Novel COVID Era-Related Oromandibular Dyskinesia: Surgical Mask-Induced Dyskinesia?
- Author
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Akhoundi FH, Lang AE, Ghazvinian S, Chitsaz A, Emamikhah M, and Rohani M
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- Humans, COVID-19, Dyskinesias etiology, Dystonia
- Published
- 2022
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5. Safety and Outcomes of Intravenous Thrombolytic Therapy in Ischemic Stroke Patients with COVID-19: CASCADE Initiative.
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Sasanejad P, Afshar Hezarkhani L, Arsang-Jang S, Tsivgoulis G, Ghoreishi A, Barlinn K, Rahmig J, Farhoudi M, Sadeghi Hokmabadi E, Borhani-Haghighi A, Sariaslani P, Sharifi-Razavi A, Ghandehari K, Khosravi A, Smith C, Nilanont Y, Akbari Y, Nguyen TN, Bersano A, Yassi N, Yoshimoto T, Lattanzi S, Gupta A, Zand R, Rafie S, Pourandokht Mousavian S, Reza Shahsavaripour M, Amini S, Kamenova SU, Kondybayeva A, Zhanuzakov M, Macri EM, Nobleza COS, Ruland S, Cervantes-Arslanian AM, Desai MJ, Ranta A, Moghadam Ahmadi A, Rostamihosseinkhani M, Foroughi R, Hooshmandi E, Akhoundi FH, Shuaib A, Liebeskind DS, Siegler J, Romano JG, Mayer SA, Bavarsad Shahripour R, Zamani B, Woolsey A, Fazli Y, Mojtaba K, Isaac CF, Biller J, Di Napoli M, and Azarpazhooh MR
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- Aged, Aged, 80 and over, COVID-19 diagnosis, COVID-19 mortality, Disability Evaluation, Europe, Female, Fibrinolytic Agents adverse effects, Hospital Mortality, Humans, Infusions, Intravenous, Intracranial Hemorrhages chemically induced, Iran, Ischemic Stroke complications, Ischemic Stroke diagnosis, Ischemic Stroke mortality, Male, Middle Aged, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, COVID-19 complications, Fibrinolytic Agents administration & dosage, Ischemic Stroke drug therapy, Thrombolytic Therapy adverse effects, Thrombolytic Therapy mortality
- Abstract
Background: There is little information regarding the safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke and COVID-19., Methods: This multicenter study included consecutive stroke patients with and without COVID-19 treated with IV-tPA between February 18, 2019, to December 31, 2020, at 9 centers participating in the CASCADE initiative. Clinical outcomes included modified Rankin Scale (mRS) at hospital discharge, in-hospital mortality, the rate of hemorrhagic transformation. Using Bayesian multiple regression and after adjusting for variables with significant value in univariable analysis, we reported the posterior adjusted odds ratio (OR, with 95% Credible Intervals [CrI]) of the main outcomes., Results: A total of 545 stroke patients, including 101 patients with COVID-19 were evaluated. Patients with COVID-19 had a more severe stroke at admission. In the study cohort, 85 (15.9%) patients had a hemorrhagic transformation, and 72 (13.1%) died in the hospital. After adjustment for confounding variables, discharge mRS score ≥2 (OR: 0.73, 95% CrI: 0.16, 3.05), in-hospital mortality (OR: 2.06, 95% CrI: 0.76, 5.53), and hemorrhagic transformation (OR: 1.514, 95% CrI: 0.66, 3.31) were similar in COVID-19 and non COVID-19 patients. High-sensitivity C reactive protein level was a predictor of hemorrhagic transformation in all cases (OR:1.01, 95%CI: 1.0026, 1.018), including those with COVID-19 (OR:1.024, 95%CI:1.002, 1.054)., Conclusion: IV-tPA treatment in patients with acute ischemic stroke and COVID-19 was not associated with an increased risk of disability, mortality, and hemorrhagic transformation compared to those without COVID-19. IV-tPA should continue to be considered as the standard of care in patients with hyper acute stroke and COVID-19., Competing Interests: Declaration of Competing Interest Authors reports no disclosures., (Copyright © 2021. Published by Elsevier Inc.)
- Published
- 2021
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6. Coexistence of deep brain stimulators and cardiac implantable electronic devices: A systematic review of safety.
- Author
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Akhoundi FH, Contarino MF, Fasano A, Vaidyanathan J, Ziaee M, Tabatabaee SN, and Rohani M
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- Comorbidity, Heart Diseases epidemiology, Humans, Movement Disorders epidemiology, Defibrillators, Implantable adverse effects, Defibrillators, Implantable standards, Heart Diseases therapy, Implantable Neurostimulators adverse effects, Implantable Neurostimulators standards, Movement Disorders therapy, Pacemaker, Artificial adverse effects, Pacemaker, Artificial standards, Patient Safety
- Abstract
As the number of patients implanted with deep brain stimulation systems increases, coexistence with cardiac implantable electronic devices (CIEDs) poses questions about safety. We systematically reviewed the literature on coexisting DBS and CIED. Eighteen reports of 34 patients were included. Device-device interactions were reported in 6 patients. Sources of complications were extensively reviewed and cautious measures which could be considered as part of a standard checklist for careful consideration are suggested., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
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- 2021
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7. Vertebral Artery Dissection After Sleeve Gastrectomy: a Case Report.
- Author
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Daryabari SN, Akhoundi FH, Aghajani E, and Kermansaravi M
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- 2020
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8. Description of combined ARHSP/JALS phenotype in some patients with SPG11 mutations.
- Author
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Khani M, Shamshiri H, Fatehi F, Rohani M, Haghi Ashtiani B, Akhoundi FH, Alavi A, Moazzeni H, Taheri H, Ghani MT, Javanparast L, Hashemi SS, Haji-Seyed-Javadi R, Heidari M, Nafissi S, and Elahi E
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- Adolescent, Adult, Corpus Callosum diagnostic imaging, Diagnosis, Differential, Electrodiagnosis, Female, Genetic Testing, Humans, Magnetic Resonance Imaging, Male, Spastic Paraplegia, Hereditary diagnosis, Mutation, Phenotype, Proteins genetics, Spastic Paraplegia, Hereditary genetics
- Abstract
Background: SPG11 mutations can cause autosomal recessive hereditary spastic paraplegia (ARHSP) and juvenile amyotrophic lateral sclerosis (JALS). Because these diseases share some clinical presentations and both can be caused by SPG11 mutations, it was considered that definitive diagnosis may not be straight forward., Methods: The DNAs of referred ARHSP and JALS patients were exome sequenced. Clinical data of patients with SPG11 mutations were gathered by interviews and neurological examinations including electrodiagnosis (EDX) and magnetic resonance imaging (MRI)., Results: Eight probands with SPG11 mutations were identified. Two mutations are novel. Among seven Iranian probands, six carried the p.Glu1026Argfs*4-causing mutation. All eight patients had features known to be present in both ARHSP and JALS. Additionally and surprisingly, presence of both thin corpus callosum (TCC) on MRI and motor neuronopathy were also observed in seven patients. These presentations are, respectively, key suggestive features of ARHSP and JALS., Conclusion: We suggest that rather than ARHSP or JALS, combined ARHSP/JALS is the appropriate description of seven patients studied. Criteria for ARHSP, JALS, and combined ARHSP/JALS designations among patients with SPG11 mutations are suggested. The importance of performing both EDX and MRI is emphasized. Initial screening for p.Glu1026Argfs*4 may facilitate SPG11 screenings in Iranian patients., (© 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.)
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- 2020
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9. Endocrine Abnormalities in a Case of Neurodegeneration with Brain Iron Accumulation.
- Author
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Haeri G, Akhoundi FH, Alavi A, Abdi S, and Rohani M
- Abstract
Competing Interests: All authors testify there was no funding for this work. The authors report no conflicts of interest.
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- 2020
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10. Beta-propeller protein associated neurodegeneration (BPAN); the first report of three patients from Iran with de novo novel mutations.
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Rohani M, Fasano A, Akhoundi FH, Haeri G, Lang AE, Rahimi Bidgoli MM, Javanparast L, Zamani B, Shahidi G, and Alavi A
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- Adult, Carrier Proteins genetics, Female, Humans, Iran, Iron Metabolism Disorders genetics, Iron Metabolism Disorders pathology, Iron Metabolism Disorders physiopathology, Magnetic Resonance Imaging, Neuroaxonal Dystrophies genetics, Neuroaxonal Dystrophies pathology, Neuroaxonal Dystrophies physiopathology, Ultrasonography, Doppler, Transcranial, Young Adult, Iron Metabolism Disorders diagnosis, Neuroaxonal Dystrophies diagnosis
- Published
- 2019
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11. Reduced retinal nerve fiber layer (RNFL) thickness in ALS patients: a window to disease progression.
- Author
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Rohani M, Meysamie A, Zamani B, Sowlat MM, and Akhoundi FH
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- Aged, Amyotrophic Lateral Sclerosis physiopathology, Case-Control Studies, Disease Progression, Female, Humans, Male, Middle Aged, Pupil, Tomography, Optical Coherence, Amyotrophic Lateral Sclerosis pathology, Nerve Fibers pathology, Retina pathology
- Abstract
Objectives: To assess RNFL thickness in ALS patients and compare it to healthy controls, and to detect possible correlations between RNFL thickness in ALS patients and disease severity and duration., Methods: Study population consisted of ALS patients and age- and sex-matched controls. We used the revised ALS functional rating scale (ALSFRS-R) as a measure of disease severity. RNFL thickness in the four quadrants were measured with a spectral domain OCT (Topcon 3D, 2015)., Results: We evaluated 20 ALS patients (40 eyes) and 25 healthy matched controls. Average RNFL thickness in ALS patients was significantly reduced compared to controls (102.57 ± 13.46 compared to 97.11 ± 10.76, p 0.04). There was a significant positive correlation between the functional abilities of the patients based on the ALSFRS-R and average RNFL thickness and also RNFL thickness in most quadrants. A linear regression analysis proved that this correlation was independent of age. In ALS patients, RNFL thickness in the nasal quadrant of the left eyes was significantly reduced compared to the corresponding quadrant in the right eyes even after adjustment for multiplicity (85.80 ± 23.20 compared to 96.80 ± 16.96, p = 0.008)., Conclusion: RNFL thickness in ALS patients is reduced compared to healthy controls. OCT probably could serve as a marker of neurodegeneration and progression of the disease in ALS patients. RNFL thickness is different among the right and left eyes of ALS patients pointing to the fact that asymmetric CNS involvement in ALS is not confined to the motor system.
- Published
- 2018
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12. Tardive Akathisia with Asymmetric and Upper-body Presentation: Report of Two Cases and Literature Review.
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Shahidi G, Rohani M, Munhoz RP, and Akhoundi FH
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- Adult, Antipsychotic Agents adverse effects, Humans, Male, Mental Disorders drug therapy, Psychiatric Status Rating Scales, Akathisia, Drug-Induced physiopathology, Psychomotor Agitation physiopathology, Tardive Dyskinesia chemically induced, Tardive Dyskinesia physiopathology, Upper Extremity physiopathology
- Abstract
Background: Akathisia is an inner urge to move a body area with an objective motor component of restlessness. Tardive akathisia (TA) is usually bilateral with a predominant lower-body presentation. We report two patients with an asymmetrical predominantly upper-body involvement., Case Report: Two young men with history of psychiatric problems and neuroleptic use revealed atypical TA, characterized by asymmetrical and predominantly upper-body involvement. Their main manifestations were rubbing the face, mostly with one hand, accompanied by an inner sensation of restlessness., Discussion: Our patients are proof that TA can present with asymmetrical and upper-body involvement even with normal brain imaging., Competing Interests: Funding: None. Conflict of Interests: The authors report no conflict of interest. Ethics Statement: All patients that appear on video have provided written informed consent; authorization for the videotaping and for publication of the videotape was provided.
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- 2018
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13. Carotid duplex ultrasound and transcranial Doppler findings in commercial divers and pilots.
- Author
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Dormanesh B, Vosoughi K, Akhoundi FH, Mehrpour M, Fereshtehnejad SM, Esmaeili S, and Sabet AS
- Subjects
- Adult, Blood Flow Velocity physiology, Carotid Intima-Media Thickness, Carotid Stenosis, Female, Functional Laterality, Humans, Male, Middle Aged, ROC Curve, Regional Blood Flow physiology, Retrospective Studies, Automobile Driving, Carotid Artery, Internal diagnostic imaging, Pilots, Ultrasonography, Doppler, Duplex
- Abstract
The risky working environments of divers and pilots, and the possible role of extreme ambient pressure in carotid stenosis, make ischemic stroke an important occupational concern among these professionals. In this study, we aimed to evaluate the association of being exposed to hyperbaric or hypobaric conditions with carotid artery stenosis by comparing common carotid intima-media thickness (CCIMT) and blood flow velocities of cerebral arteries in divers and pilots using carotid duplex ultrasound (CDUS) and transcranial Doppler (TCD). CDUS and transtemporal TCD were performed in 29 divers, 36 pilots and 30 control participants. Medical history, blood pressure, lipid profile and blood sugar were recorded to control the previously well-known risk factors of atherosclerosis. Findings of the CDUS and TCD [including: CCIMT and blood flow velocities of internal carotid artery (ICA), common carotid artery (CCA), and middle cerebral artery (MCA)] of divers and pilots were compared with those of the control group using regression analysis models. Both right and left side CCIMT were significantly higher in divers (P < 0.05) and pilots (P < 0.05) in comparison with the control group. Carotid index [peak systolic velocity (PSV) of ICA/PSV of CCA) of divers and pilots were also higher than the control group. TCD findings were not significantly different between divers, pilots, and the control group. Increased CCIMT and carotid index in diver and pilot groups appear to be suggestive of accelerated atherosclerosis of carotid artery in these occupational groups.
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- 2016
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14. Effects of fasting during Ramadan on cerebrovascular hemodynamics: A transcranial Doppler study.
- Author
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Mehrpour M, Akhoundi FH, and Rezaei Z
- Abstract
Background: To determine whether Islamic fasting would change cerebral blood flow during Ramadan., Methods: The study group comprised 20 subjects (16 males and 4 females) on a regimen of 1 month food and water intake restriction, according to Islamic fasting ritual. Subjects were evaluated for cerebral bolo flow through a middle cerebral artery (MCA) by means of transcranial Doppler (TCD), the day before starting Ramadan fasting and the day after the month of Ramadan., Results: Our results showed no statistically significant changes after Ramadan in cerebrovascular hemodynamic, in comparison before Ramadan., Conclusion: Although some studies showed metabolic changes during Ramadan fasting (increasing hematocrite, decreasing amount of hemoglobin, dehydration, platelet aggregation, and lipid profile alternations) the findings suggest that Islamic fasting has no significant effects on cerebral blood flow.
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- 2016
15. Increased Serum Brain-derived Neurotrophic Factor in Multiple Sclerosis Patients on Interferon-β and Its Impact on Functional Abilities.
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Mehrpour M, Akhoundi FH, Delgosha M, Keyvani H, Motamed MR, Sheibani B, and Meysamie A
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- Adult, Analysis of Variance, Cross-Sectional Studies, Disability Evaluation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulins, Intravenous therapeutic use, Male, Middle Aged, ROC Curve, Young Adult, Brain-Derived Neurotrophic Factor blood, Immunologic Factors therapeutic use, Interferon-beta therapeutic use, Multiple Sclerosis blood, Multiple Sclerosis drug therapy
- Abstract
Objectives: To investigate the potential role of disease-modifying therapies (DMTs) used to treat multiple sclerosis on inducing brain-derived neurotrophic factor (BDNF) production., Methods: A total of 82 patients entered the study. Sixty (73%) patients were on DMTs (15 on Avonex, 13 on Rebif, 27 on Betaferon, 3 on Mitoxantrone, and 2 on IVIg), whereas 22 received no DMTs. The degree of neurological impairment was recorded using the expanded disability status scale (EDSS). Serum BDNF levels were assessed using the Sandwich ELISA method. We compared mean serum BDNF levels among patient groups based on whether or not they were on DMTs, and the specific agent used. Then, the relationship between BDNF levels and EDSS scores was assessed. The receiver operating characteristic (ROC) curve was used to calculate a cutoff value by which serum BDNF could predict the degree of disability., Results: The study sample had a mean age of 34.6 years, mean EDSS score of 3.8, and mean BDNF level of 198.9 pg/mL. Patients on interferon-β 1b therapy had significantly higher levels of BDNF compared with patients on Mitoxantrone or patients not on DMTs (237.6, 68.6, and 155.9, respectively; P=0.003). The degree of neurological impairment correlated negatively with BDNF levels (P<0.001). A cutoff value of 190 pg/mL was calculated for BDNF (ROC analysis, area under the curve: 0.729, P=0.002). At BDNF levels >190, the sensitivity for a milder degree of neurological impairment (EDSS<3) was 80%., Conclusions: This study showed a significant effect of interferon-β 1b therapy on increasing BDNF production in multiple sclerosis.
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- 2015
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16. Palatal-Myoclonus as a Presentation of Hashimoto Encephalopathy: an interesting case report.
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Ghoreishi E, Shahidi GA, Rohani M, Nabavi M, Aghaei M, and Akhoundi FH
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Objective: Hashimoto encephalopathy (HE) is known as a steroid- responsive encephalopathy associated with autoimmune thyroiditis or nonvascular inflammation-related autoimmune meningoencephalitis. The average age of onset of HE is approximately 50 years; and it is more common in women. The onset of HE may be acute or subacute. The course of most HE cases is relapsing and remitting, which is similar to that of vasculitis and stroke., Methods: In this article, we present a previously healthy 32 years old;veterinarian male with palatal myoclonus, as a rare presentation of this disorder, and review the neurologic aspects of hashimoto encephalitis., Results: The clinical presentation of HE is characterized by progressive cognitive decline tremor, transient aphasia, seizures, abnormal gait, sleep disorder and stroke-like episodes. Myoclonus, either generalized or multifocal, and tremor, often of the bilateral upper extremities, is the most frequently observed involuntary movements in HE., Conclusion: The rapidly progressive cognitive dysfunction and encephalopathies observed.
- Published
- 2013
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