Author: "Aken, Bronwen" - Searchworks@Jio Institute Digital Library Search Results

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255 results on '"Aken, Bronwen"'

1. The comparative genomics and complex population history of Papio baboons.

Author: Rogers, Jeffrey, Raveendran, Muthuswamy, Harris, R, Mailund, Thomas, Leppälä, Kalle, Athanasiadis, Georgios, Schierup, Mikkel, Cheng, Jade, Munch, Kasper, Walker, Jerilyn, Konkel, Miriam, Jordan, Vallmer, Steely, Cody, Beckstrom, Thomas, Bergey, Christina, Burrell, Andrew, Schrempf, Dominik, Noll, Angela, Kothe, Maximillian, Kopp, Gisela, Liu, Yue, Murali, Shwetha, Billis, Konstantinos, Martin, Fergal, Muffato, Matthieu, Cox, Laura, Else, James, Disotell, Todd, Muzny, Donna, Phillips-Conroy, Jane, Aken, Bronwen, Eichler, Evan, Marques-Bonet, Tomas, Kosiol, Carolin, Batzer, Mark, Hahn, Matthew, Tung, Jenny, Zinner, Dietmar, Roos, Christian, Jolly, Clifford, Gibbs, Richard, and Worley, Kim
Subjects: Animals, Base Sequence, Biological Evolution, Female, Gene Flow, Genomics, Haplotypes, Humans, Hybridization, Genetic, Male, Papio, Phylogeny, Polymorphism, Genetic, Whole Genome Sequencing
Abstract: Recent studies suggest that closely related species can accumulate substantial genetic and phenotypic differences despite ongoing gene flow, thus challenging traditional ideas regarding the genetics of speciation. Baboons (genus Papio) are Old World monkeys consisting of six readily distinguishable species. Baboon species hybridize in the wild, and prior data imply a complex history of differentiation and introgression. We produced a reference genome assembly for the olive baboon (Papio anubis) and whole-genome sequence data for all six extant species. We document multiple episodes of admixture and introgression during the radiation of Papio baboons, thus demonstrating their value as a model of complex evolutionary divergence, hybridization, and reticulation. These results help inform our understanding of similar cases, including modern humans, Neanderthals, Denisovans, and other ancient hominins.
Published: 2019

2. Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.

Author: Jasinska, Anna J, Zelaya, Ivette, Service, Susan K, Peterson, Christine B, Cantor, Rita M, Choi, Oi-Wa, DeYoung, Joseph, Eskin, Eleazar, Fairbanks, Lynn A, Fears, Scott, Furterer, Allison E, Huang, Yu S, Ramensky, Vasily, Schmitt, Christopher A, Svardal, Hannes, Jorgensen, Matthew J, Kaplan, Jay R, Villar, Diego, Aken, Bronwen L, Flicek, Paul, Nag, Rishi, Wong, Emily S, Blangero, John, Dyer, Thomas D, Bogomolov, Marina, Benjamini, Yoav, Weinstock, George M, Dewar, Ken, Sabatti, Chiara, Wilson, Richard K, Jentsch, J David, Warren, Wesley, Coppola, Giovanni, Woods, Roger P, and Freimer, Nelson B
Subjects: Brain, Animals, Humans, Gene Expression Profiling, Genotype, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genetic Variation, Genome-Wide Association Study, Chlorocebus aethiops, Genetics, Biotechnology, Human Genome, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract: By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
Published: 2017

3. The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

Author: Braasch, Ingo, Gehrke, Andrew R, Smith, Jeramiah J, Kawasaki, Kazuhiko, Manousaki, Tereza, Pasquier, Jeremy, Amores, Angel, Desvignes, Thomas, Batzel, Peter, Catchen, Julian, Berlin, Aaron M, Campbell, Michael S, Barrell, Daniel, Martin, Kyle J, Mulley, John F, Ravi, Vydianathan, Lee, Alison P, Nakamura, Tetsuya, Chalopin, Domitille, Fan, Shaohua, Wcisel, Dustin, Cañestro, Cristian, Sydes, Jason, Beaudry, Felix EG, Sun, Yi, Hertel, Jana, Beam, Michael J, Fasold, Mario, Ishiyama, Mikio, Johnson, Jeremy, Kehr, Steffi, Lara, Marcia, Letaw, John H, Litman, Gary W, Litman, Ronda T, Mikami, Masato, Ota, Tatsuya, Saha, Nil Ratan, Williams, Louise, Stadler, Peter F, Wang, Han, Taylor, John S, Fontenot, Quenton, Ferrara, Allyse, Searle, Stephen MJ, Aken, Bronwen, Yandell, Mark, Schneider, Igor, Yoder, Jeffrey A, Volff, Jean-Nicolas, Meyer, Axel, Amemiya, Chris T, Venkatesh, Byrappa, Holland, Peter WH, Guiguen, Yann, Bobe, Julien, Shubin, Neil H, Di Palma, Federica, Alföldi, Jessica, Lindblad-Toh, Kerstin, and Postlethwait, John H
Subjects: Biological Sciences, Bioinformatics and Computational Biology, Genetics, Human Genome, Animals, Evolution, Molecular, Female, Fishes, Genome, Humans, Karyotype, Models, Genetic, Organ Specificity, Sequence Analysis, DNA, Transcriptome, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract: To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.
Published: 2016

4. The genome of the vervet (Chlorocebus aethiops sabaeus)

Author: Warren, Wesley C, Jasinska, Anna J, García-Pérez, Raquel, Svardal, Hannes, Tomlinson, Chad, Rocchi, Mariano, Archidiacono, Nicoletta, Capozzi, Oronzo, Minx, Patrick, Montague, Michael J, Kyung, Kim, Hillier, LaDeana W, Kremitzki, Milinn, Graves, Tina, Chiang, Colby, Hughes, Jennifer, Tran, Nam, Huang, Yu, Ramensky, Vasily, Choi, Oi-wa, Jung, Yoon J, Schmitt, Christopher A, Juretic, Nikoleta, Wasserscheid, Jessica, Turner, Trudy R, Wiseman, Roger W, Tuscher, Jennifer J, Karl, Julie A, Schmitz, Jörn E, Zahn, Roland, O'Connor, David H, Redmond, Eugene, Nisbett, Alex, Jacquelin, Béatrice, Müller-Trutwin, Michaela C, Brenchley, Jason M, Dione, Michel, Antonio, Martin, Schroth, Gary P, Kaplan, Jay R, Jorgensen, Matthew J, Thomas, Gregg WC, Hahn, Matthew W, Raney, Brian J, Aken, Bronwen, Nag, Rishi, Schmitz, Juergen, Churakov, Gennady, Noll, Angela, Stanyon, Roscoe, Webb, David, Thibaud-Nissen, Francoise, Nordborg, Magnus, Marques-Bonet, Tomas, Dewar, Ken, Weinstock, George M, Wilson, Richard K, and Freimer, Nelson B
Subjects: Human Genome, Biotechnology, Genetics, Infection, Animals, Chlorocebus aethiops, Chromosome Painting, Computational Biology, Evolution, Molecular, Gene Rearrangement, Genetic Variation, Genome, Genomics, Karyotype, Major Histocompatibility Complex, Molecular Sequence Annotation, Phylogeny, Phylogeography, Biological Sciences, Medical and Health Sciences, Bioinformatics
Abstract: We describe a genome reference of the African green monkey or vervet (Chlorocebus aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for genetic investigations of simian immunodeficiency virus (SIV), for which it is the most abundant natural host species, and of a wide range of health-related phenotypes assessed in Caribbean vervets (C. a. sabaeus), whose numbers have expanded dramatically since Europeans introduced small numbers of their ancestors from West Africa during the colonial era. We use the reference to characterize the genomic relationship between vervets and other primates, the intra-generic phylogeny of vervet subspecies, and genome-wide structural variations of a pedigreed C. a. sabaeus population. Through comparative analyses with human and rhesus macaque, we characterize at high resolution the unique chromosomal fission events that differentiate the vervets and their close relatives from most other catarrhine primates, in whom karyotype is highly conserved. We also provide a summary of transposable elements and contrast these with the rhesus macaque and human. Analysis of sequenced genomes representing each of the main vervet subspecies supports previously hypothesized relationships between these populations, which range across most of sub-Saharan Africa, while uncovering high levels of genetic diversity within each. Sequence-based analyses of major histocompatibility complex (MHC) polymorphisms reveal extremely low diversity in Caribbean C. a. sabaeus vervets, compared to vervets from putatively ancestral West African regions. In the C. a. sabaeus research population, we discover the first structural variations that are, in some cases, predicted to have a deleterious effect; future studies will determine the phenotypic impact of these variations.
Published: 2015

5. Perspectives on ENCODE

Author: Abascal, Federico, Acosta, Reyes, Addleman, Nicholas J., Adrian, Jessika, Afzal, Veena, Aken, Bronwen, and Akiyama, Jennifer A.
Subjects: Nucleotide sequencing -- Collections and collecting -- Terminology, Bibliographic databases -- Service enhancement, DNA sequencing -- Collections and collecting -- Terminology, Consortia -- Service enhancement, Genomic libraries -- History -- Management, Consortium, Company business management, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression.sup.1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community. The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases., Author(s): Federico Abascal [sup.95] , Reyes Acosta [sup.11] , Nicholas J. Addleman [sup.1] , Jessika Adrian [sup.1] , Veena Afzal [sup.49] , Bronwen Aken [sup.19] , Jennifer A. Akiyama [sup.49] [...]
Published: 2020
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6. Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication

Author: Montague, Michael J, Li, Gang, Gandolfi, Barbara, Khan, Razib, Aken, Bronwen L, Searle, Steven MJ, Minx, Patrick, Hillier, LaDeana W, Koboldt, Daniel C, Davis, Brian W, Driscoll, Carlos A, Barr, Christina S, Blackistone, Kevin, Quilez, Javier, Lorente-Galdos, Belen, Marques-Bonet, Tomas, Alkan, Can, Thomas, Gregg WC, Hahn, Matthew W, Menotti-Raymond, Marilyn, O'Brien, Stephen J, Wilson, Richard K, Lyons, Leslie A, Murphy, William J, and Warren, Wesley C
Subjects: Human Genome, Genetics, Biotechnology, Adaptation, Physiological, Amino Acid Sequence, Animals, Animals, Domestic, Animals, Wild, Carnivory, Cats, Chromosome Mapping, DNA Copy Number Variations, Dogs, Female, Gene Deletion, Gene Duplication, Genome, Genomics, Male, Membrane Transport Proteins, Molecular Sequence Data, Phylogeny, Selection, Genetic, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Species Specificity, Felis catus, domestication, genome
Abstract: Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for genes involved in lipid metabolism that underpin adaptations to a hypercarnivorous diet. We also found positive selection signals within genes underlying sensory processes, especially those affecting vision and hearing in the carnivore lineage. We observed an evolutionary tradeoff between functional olfactory and vomeronasal receptor gene repertoires in the cat and dog genomes, with an expansion of the feline chemosensory system for detecting pheromones at the expense of odorant detection. Genomic regions harboring signatures of natural selection that distinguish domestic cats from their wild congeners are enriched in neural crest-related genes associated with behavior and reward in mouse models, as predicted by the domestication syndrome hypothesis. Our description of a previously unidentified allele for the gloving pigmentation pattern found in the Birman breed supports the hypothesis that cat breeds experienced strong selection on specific mutations drawn from random bred populations. Collectively, these findings provide insight into how the process of domestication altered the ancestral wildcat genome and build a resource for future disease mapping and phylogenomic studies across all members of the Felidae.
Published: 2014

7. The genomic substrate for adaptive radiation in African cichlid fish.

Author: Brawand, David, Wagner, Catherine E, Li, Yang I, Malinsky, Milan, Keller, Irene, Fan, Shaohua, Simakov, Oleg, Ng, Alvin Y, Lim, Zhi Wei, Bezault, Etienne, Turner-Maier, Jason, Johnson, Jeremy, Alcazar, Rosa, Noh, Hyun Ji, Russell, Pamela, Aken, Bronwen, Alföldi, Jessica, Amemiya, Chris, Azzouzi, Naoual, Baroiller, Jean-François, Barloy-Hubler, Frederique, Berlin, Aaron, Bloomquist, Ryan, Carleton, Karen L, Conte, Matthew A, D'Cotta, Helena, Eshel, Orly, Gaffney, Leslie, Galibert, Francis, Gante, Hugo F, Gnerre, Sante, Greuter, Lucie, Guyon, Richard, Haddad, Natalie S, Haerty, Wilfried, Harris, Rayna M, Hofmann, Hans A, Hourlier, Thibaut, Hulata, Gideon, Jaffe, David B, Lara, Marcia, Lee, Alison P, MacCallum, Iain, Mwaiko, Salome, Nikaido, Masato, Nishihara, Hidenori, Ozouf-Costaz, Catherine, Penman, David J, Przybylski, Dariusz, Rakotomanga, Michaelle, Renn, Suzy CP, Ribeiro, Filipe J, Ron, Micha, Salzburger, Walter, Sanchez-Pulido, Luis, Santos, M Emilia, Searle, Steve, Sharpe, Ted, Swofford, Ross, Tan, Frederick J, Williams, Louise, Young, Sarah, Yin, Shuangye, Okada, Norihiro, Kocher, Thomas D, Miska, Eric A, Lander, Eric S, Venkatesh, Byrappa, Fernald, Russell D, Meyer, Axel, Ponting, Chris P, Streelman, J Todd, Lindblad-Toh, Kerstin, Seehausen, Ole, and Di Palma, Federica
Subjects: Animals, Cichlids, MicroRNAs, DNA Transposable Elements, Genomics, Evolution, Molecular, Phylogeny, Gene Expression Regulation, Gene Duplication, Polymorphism, Genetic, Genome, Africa, Eastern, Genetic Speciation, Lakes, Africa, Eastern, Evolution, Molecular, Polymorphism, Genetic, General Science & Technology
Abstract: Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the genomes and transcriptomes of five lineages of African cichlids: the Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; and four members of the East African lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent radiation, Lake Malawi), Pundamilia nyererei (very recent radiation, Lake Victoria), and Astatotilapia burtoni (riverine species around Lake Tanganyika). We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs. In addition, we analysed sequence data from sixty individuals representing six closely related species from Lake Victoria, and show genome-wide diversifying selection on coding and regulatory variants, some of which were recruited from ancient polymorphisms. We conclude that a number of molecular mechanisms shaped East African cichlid genomes, and that amassing of standing variation during periods of relaxed purifying selection may have been important in facilitating subsequent evolutionary diversification.
Published: 2014

8. Current status and new features of the Consensus Coding Sequence database.

Author: Farrell, Catherine, OLeary, Nuala, Harte, Rachel, Loveland, Jane, Wilming, Laurens, Wallin, Craig, Diekhans, Mark, Barrell, Daniel, Searle, Stephen, Aken, Bronwen, Hiatt, Susan, Frankish, Adam, Suner, Marie-Marthe, Rajput, Bhanu, Steward, Charles, Brown, Garth, Bennett, Ruth, Murphy, Michael, Wu, Wendy, Kay, Mike, Hart, Jennifer, Rajan, Jeena, Weber, Janet, Snow, Catherine, Riddick, Lillian, Hunt, Toby, Webb, David, Thomas, Mark, Tamez, Pamela, Rangwala, Sanjida, McGarvey, Kelly, Pujar, Shashikant, Shkeda, Andrei, Mudge, Jonathan, Gonzalez, Jose, Gilbert, James, Trevanion, Stephen, Baertsch, Robert, Harrow, Jennifer, Hubbard, Tim, Ostell, James, Pruitt, Kim, and Haussler, David
Subjects: Animals, Databases, Genetic, Exons, Genomics, Humans, Internet, Mice, Molecular Sequence Annotation, Proteins, Sequence Analysis
Abstract: The Consensus Coding Sequence (CCDS) project (http://www.ncbi.nlm.nih.gov/CCDS/) is a collaborative effort to maintain a dataset of protein-coding regions that are identically annotated on the human and mouse reference genome assemblies by the National Center for Biotechnology Information (NCBI) and Ensembl genome annotation pipelines. Identical annotations that pass quality assurance tests are tracked with a stable identifier (CCDS ID). Members of the collaboration, who are from NCBI, the Wellcome Trust Sanger Institute and the University of California Santa Cruz, provide coordinated and continuous review of the dataset to ensure high-quality CCDS representations. We describe here the current status and recent growth in the CCDS dataset, as well as recent changes to the CCDS web and FTP sites. These changes include more explicit reporting about the NCBI and Ensembl annotation releases being compared, new search and display options, the addition of biologically descriptive information and our approach to representing genes for which support evidence is incomplete. We also present a summary of recent and future curation targets.
Published: 2014

9. A comprehensive genomic history of extinct and living elephants

Author: Palkopoulou, Eleftheria, Lipson, Mark, Mallick, Swapan, Nielsen, Svend, Rohland, Nadin, Baleka, Sina, Karpinski, Emil, Ivancevic, Atma M., To, Thu-Hien, Kortschak, R. Daniel, Raison, Joy M., Qu, Zhipeng, Chin, Tat-Jun, Alt, Kurt W., Claesson, Stefan, Dalén, Love, MacPhee, Ross D. E., Meller, Harald, Roca, Alfred L., Ryder, Oliver A., Heiman, David, Young, Sarah, Breen, Matthew, Williams, Christina, Aken, Bronwen L., Ruffier, Magali, Karlsson, Elinor, Johnson, Jeremy, Di Palma, Federica, Alfoldi, Jessica, Adelson, David L., Mailund, Thomas, Munch, Kasper, Lindblad-Toh, Kerstin, Hofreiter, Michael, Poinar, Hendrik, and Reich, David
Published: 2018

10. Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Author: Warren, Wesley C., García-Pérez, Raquel, Xu, Sen, Lampert, Kathrin P., Chalopin, Domitille, Stöck, Matthias, Loewe, Laurence, Lu, Yuan, Kuderna, Lukas, Minx, Patrick, Montague, Michael J., Tomlinson, Chad, Hillier, LaDeana W., Murphy, Daniel N., Wang, John, Wang, Zhongwei, Garcia, Constantino Macias, Thomas, Gregg C. W., Volff, Jean-Nicolas, Farias, Fabiana, Aken, Bronwen, Walter, Ronald B., Pruitt, Kim D., Marques-Bonet, Tomas, Hahn, Matthew W., Kneitz, Susanne, Lynch, Michael, and Schartl, Manfred
Published: 2018
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11. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication

Author: Carneiro, Miguel, Rubin, Carl-Johan, Di Palma, Federica, Albert, Frank W., Alföldi, Jessica, Barrio, Alvaro Martinez, Pielberg, Gerli, Rafati, Nima, Sayyab, Shumaila, Turner-Maier, Jason, Younis, Shady, Afonso, Sandra, Aken, Bronwen, Alves, Joel M., Barrell, Daniel, Bolet, Gerard, Boucher, Samuel, Burbano, Hernán A., Campos, Rita, Chang, Jean L., Duranthon, Veronique, Fontanesi, Luca, Garreau, Hervé, Heiman, David, Johnson, Jeremy, Mage, Rose G., Peng, Ze, Queney, Guillaume, Rogel-Gaillard, Claire, Ruffier, Magali, Searle, Steve, Villafuerte, Rafael, Xiong, Anqi, Young, Sarah, Forsberg-Nilsson, Karin, Good, Jeffrey M., Lander, Eric S., Ferrand, Nuno, Lindblad-Toh, Kerstin, and Andersson, Leif
Published: 2014

12. The sheep genome illuminates biology of the rumen and lipid metabolism

Author: Jiang, Yu, Xie, Min, Chen, Wenbin, Talbot, Richard, Maddox, Jillian F., Faraut, Thomas, Wu, Chunhua, Muzny, Donna M., Li, Yuxiang, Zhang, Wenguang, Stanton, Jo-Ann, Brauning, Rudiger, Barris, Wesley C., Hourlier, Thibaut, Aken, Bronwen L., Searle, Stephen M. J., Adelson, David L., Bian, Chao, Cam, Graham R., Chen, Yulin, Cheng, Shifeng, DeSilva, Udaya, Dixen, Karen, Dong, Yang, Fan, Guangyi, Franklin, Ian R., Fu, Shaoyin, Fuentes-Utrilla, Pablo, Guan, Rui, Highland, Margaret A., Holder, Michael E., Huang, Guodong, Ingham, Aaron B., Jhangiani, Shalini N., Kalra, Divya, Kovar, Christie L., Lee, Sandra L., Liu, Weiqing, Liu, Xin, Lu, Changxin, Lv, Tian, Mathew, Tittu, McWilliam, Sean, Menzies, Moira, Pan, Shengkai, Robelin, David, Servin, Bertrand, Townley, David, Wang, Wenliang, Wei, Bin, White, Stephen N., Yang, Xinhua, Ye, Chen, Yue, Yaojing, Zeng, Peng, Zhou, Qing, Hansen, Jacob B., Kristiansen, Karsten, Gibbs, Richard A., Flicek, Paul, Warkup, Christopher C., Jones, Huw E., Oddy, V. Hutton, Nicholas, Frank W., McEwan, John C., Kijas, James W., Wang, Jun, Worley, Kim C., Archibald, Alan L., Cockett, Noelle, Xu, Xun, Wang, Wen, and Dalrymple, Brian P.
Published: 2014

13. GENCODE reference annotation for the human and mouse genomes

Author: Frankish, Adam, Diekhans, Mark, Ferreira, Anne-Maud, Johnson, Rory, Jungreis, Irwin, Loveland, Jane, Mudge, Jonathan M, Sisu, Cristina, Wright, James, Armstrong, Joel, Barnes, If, Berry, Andrew, Bignell, Alexandra, Carbonell Sala, Silvia, Chrast, Jacqueline, Cunningham, Fiona, Di Domenico, Tomás, Donaldson, Sarah, Fiddes, Ian T, García Girón, Carlos, Gonzalez, Jose Manuel, Grego, Tiago, Hardy, Matthew, Hourlier, Thibaut, Hunt, Toby, Izuogu, Osagie G, Lagarde, Julien, Martin, Fergal J, Martínez, Laura, Mohanan, Shamika, Muir, Paul, Navarro, Fabio C P, Parker, Anne, Pei, Baikang, Pozo, Fernando, Ruffier, Magali, Schmitt, Bianca M, Stapleton, Eloise, Suner, Marie-Marthe, Sycheva, Irina, Uszczynska-Ratajczak, Barbara, Xu, Jinuri, Yates, Andrew, Zerbino, Daniel, Zhang, Yan, Aken, Bronwen, Choudhary, Jyoti S, Gerstein, Mark, Guigó, Roderic, Hubbard, Tim J P, Kellis, Manolis, Paten, Benedict, Reymond, Alexandre, Tress, Michael L, Flicek, Paul, Frankish, Adam, Diekhans, Mark, Ferreira, Anne-Maud, Johnson, Rory, Jungreis, Irwin, Loveland, Jane, Mudge, Jonathan M, Sisu, Cristina, Wright, James, Armstrong, Joel, Barnes, If, Berry, Andrew, Bignell, Alexandra, Carbonell Sala, Silvia, Chrast, Jacqueline, Cunningham, Fiona, Di Domenico, Tomás, Donaldson, Sarah, Fiddes, Ian T, García Girón, Carlos, Gonzalez, Jose Manuel, Grego, Tiago, Hardy, Matthew, Hourlier, Thibaut, Hunt, Toby, Izuogu, Osagie G, Lagarde, Julien, Martin, Fergal J, Martínez, Laura, Mohanan, Shamika, Muir, Paul, Navarro, Fabio C P, Parker, Anne, Pei, Baikang, Pozo, Fernando, Ruffier, Magali, Schmitt, Bianca M, Stapleton, Eloise, Suner, Marie-Marthe, Sycheva, Irina, Uszczynska-Ratajczak, Barbara, Xu, Jinuri, Yates, Andrew, Zerbino, Daniel, Zhang, Yan, Aken, Bronwen, Choudhary, Jyoti S, Gerstein, Mark, Guigó, Roderic, Hubbard, Tim J P, Kellis, Manolis, Paten, Benedict, Reymond, Alexandre, Tress, Michael L, and Flicek, Paul
Abstract: © 2018 The Author(s). The accurate identification and description of the genes in the human and mouse genomes is a fundamental requirement for high quality analysis of data informing both genome biology and clinical genomics. Over the last 15 years, the GENCODE consortium has been producing reference quality gene annotations to provide this foundational resource. The GENCODE consortium includes both experimental and computational biology groups who work together to improve and extend theGENCODE gene annotation. Specifically, we generate primary data, create bioinformatics tools and provide analysis to support the work of expert manual gene annotators and automated gene annotation pipelines. In addition, manual and computational annotation workflows use any and all publicly available data and analysis, along with the research literature to identify and characterise gene loci to the highest standard. GENCODE gene annotations are accessible via the Ensembl and UCSC Genome Browsers, the Ensembl FTP site, Ensembl Biomart, Ensembl Perl and REST APIs as well as https://www.gencodegenes.org.
Published: 2022

14. Gibbon genome and the fast karyotype evolution of small apes

Author: Carbone, Lucia, Alan Harris, R., Gnerre, Sante, Veeramah, Krishna R., Lorente-Galdos, Belen, Huddleston, John, Meyer, Thomas J., Herrero, Javier, Roos, Christian, Aken, Bronwen, Anaclerio, Fabio, Archidiacono, Nicoletta, Baker, Carl, Barrell, Daniel, Batzer, Mark A., Beal, Kathryn, Blancher, Antoine, Bohrson, Craig L., Brameier, Markus, Campbell, Michael S., Capozzi, Oronzo, Casola, Claudio, Chiatante, Giorgia, Cree, Andrew, Damert, Annette, de Jong, Pieter J., Dumas, Laura, Fernandez-Callejo, Marcos, Flicek, Paul, Fuchs, Nina V., Gut, Ivo, Gut, Marta, Hahn, Matthew W., Hernandez-Rodriguez, Jessica, Hillier, LaDeana W., Hubley, Robert, Ianc, Bianca, Izsvák, Zsuzsanna, Jablonski, Nina G., Johnstone, Laurel M., Karimpour-Fard, Anis, Konkel, Miriam K., Kostka, Dennis, Lazar, Nathan H., Lee, Sandra L., Lewis, Lora R., Liu, Yue, Locke, Devin P., Mallick, Swapan, Mendez, Fernando L., Muffato, Matthieu, Nazareth, Lynne V., Nevonen, Kimberly A., O’Bleness, Majesta, Ochis, Cornelia, Odom, Duncan T., Pollard, Katherine S., Quilez, Javier, Reich, David, Rocchi, Mariano, Schumann, Gerald G., Searle, Stephen, Sikela, James M., Skollar, Gabriella, Smit, Arian, Sonmez, Kemal, Hallers, Boudewijn ten, Terhune, Elizabeth, Thomas, Gregg W. C., Ullmer, Brygg, Ventura, Mario, Walker, Jerilyn A., Wall, Jeffrey D., Walter, Lutz, Ward, Michelle C., Wheelan, Sarah J., Whelan, Christopher W., White, Simon, Wilhelm, Larry J., Woerner, August E., Yandell, Mark, Zhu, Baoli, Hammer, Michael F., Marques-Bonet, Tomas, Eichler, Evan E., Fulton, Lucinda, Fronick, Catrina, Muzny, Donna M., Warren, Wesley C., Worley, Kim C., Rogers, Jeffrey, Wilson, Richard K., and Gibbs, Richard A.
Published: 2014
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15. Ensembl 2015

Author: Cunningham, Fiona, Amode, Ridwan M., Barrell, Daniel, Beal, Kathryn, Billis, Konstantinos, Brent, Simon, Carvalho-Silva, Denise, Clapham, Peter, Coates, Guy, Fitzgerald, Stephen, Gil, Laurent, Girón, Carlos García, Gordon, Leo, Hourlier, Thibaut, Hunt, Sarah E., Janacek, Sophie H., Johnson, Nathan, Juettemann, Thomas, Kähäri, Andreas K., Keenan, Stephen, Martin, Fergal J., Maurel, Thomas, McLaren, William, Murphy, Daniel N., Nag, Rishi, Overduin, Bert, Parker, Anne, Patricio, Mateus, Perry, Emily, Pignatelli, Miguel, Riat, Harpreet Singh, Sheppard, Daniel, Taylor, Kieron, Thormann, Anja, Vullo, Alessandro, Wilder, Steven P., Zadissa, Amonida, Aken, Bronwen L., Birney, Ewan, Harrow, Jennifer, Kinsella, Rhoda, Muffato, Matthieu, Ruffier, Magali, Searle, Stephen M.J., Spudich, Giulietta, Trevanion, Stephen J., Yates, Andy, Zerbino, Daniel R., and Flicek, Paul
Published: 2015
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16. Extending reference assembly models

Author: Church, Deanna M, Schneider, Valerie A, Steinberg, Karyn Meltz, Schatz, Michael C, Quinlan, Aaron R, Chin, Chen-Shan, Kitts, Paul A, Aken, Bronwen, Marth, Gabor T, Hoffman, Michael M, Herrero, Javier, Mendoza, M Lisandra Zepeda, Durbin, Richard, and Flicek, Paul
Published: 2015
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17. Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Author: Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro, Araki, Marito, Arbel, Taly, Bornholdt, Jette, Boyd, Mette, Chen, Yun, Coskun, Mehmet, Dalby, Maria, Ienasescu, Hans, Jørgensen, Mette, Kaczkowski, Bogumil, Kere, Juha, Li, Kang, Lilje, Berit, Nepal, Chirag, Nguyen, Quan Hoang, Nielsen, Lars K., Rennie, Sarah, Sandelin, Albin, Valen, Eivind, Vitezic, Morana, Vitting-Seerup, Kristoffer, Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro, Araki, Marito, Arbel, Taly, Bornholdt, Jette, Boyd, Mette, Chen, Yun, Coskun, Mehmet, Dalby, Maria, Ienasescu, Hans, Jørgensen, Mette, Kaczkowski, Bogumil, Kere, Juha, Li, Kang, Lilje, Berit, Nepal, Chirag, Nguyen, Quan Hoang, Nielsen, Lars K., Rennie, Sarah, Sandelin, Albin, Valen, Eivind, Vitezic, Morana, and Vitting-Seerup, Kristoffer
Abstract: Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene and initiate at unconventional regions, outside promoters or enhancers. Here, we probe these unassigned TSSs and show that, in all species studied, a significant fraction of CAGE peaks initiate at microsatellites, also called short tandem repeats (STRs). To confirm this transcription, we develop Cap Trap RNA-seq, a technology which combines cap trapping and long read MinION sequencing. We train sequence-based deep learning models able to predict CAGE signal at STRs with high accuracy. These models unveil the importance of STR surrounding sequences not only to distinguish STR classes, but also to predict the level of transcription initiation. Importantly, genetic variants linked to human diseases are preferentially found at STRs with high transcription initiation level, supporting the biological and clinical relevance of transcription initiation at STRs. Together, our results extend the repertoire of non-coding transcription associated with DNA tandem repeats and complexify STR polymorphism.
Published: 2021

18. Analyses of pig genomes provide insight into porcine demography and evolution

Author: Groenen, Martien A. M., Archibald, Alan L., Uenishi, Hirohide, Tuggle, Christopher K., Takeuchi, Yasuhiro, Rothschild, Max F., Rogel-Gaillard, Claire, Park, Chankyu, Milan, Denis, Megens, Hendrik-Jan, Li, Shengting, Larkin, Denis M., Kim, Heebal, Frantz, Laurent A. F., Caccamo, Mario, Ahn, Hyeonju, Aken, Bronwen L., Anselmo, Anna, Anthon, Christian, Auvil, Loretta, Badaoui, Bouabid, Beattie, Craig W., Bendixen, Christian, Berman, Daniel, Blecha, Frank, Blomberg, Jonas, Bolund, Lars, Bosse, Mirte, Botti, Sara, Bujie, Zhan, Bystrom, Megan, Capitanu, Boris, Carvalho-Silva, Denise, Chardon, Patrick, Chen, Celine, Cheng, Ryan, Choi, Sang-Haeng, Chow, William, Clark, Richard C., Clee, Christopher, Crooijmans, Richard P. M. A., Dawson, Harry D., Dehais, Patrice, De Sapio, Fioravante, Dibbits, Bert, Drou, Nizar, Du, Zhi-Qiang, Eversole, Kellye, Fadista, João, Fairley, Susan, Faraut, Thomas, Faulkner, Geoffrey J., Fowler, Katie E., Fredholm, Merete, Fritz, Eric, Gilbert, James G. R., Giuffra, Elisabetta, Gorodkin, Jan, Griffin, Darren K., Harrow, Jennifer L., Hayward, Alexander, Howe, Kerstin, Hu, Zhi-Liang, Humphray, Sean J., Hunt, Toby, Hornshøj, Henrik, Jeon, Jin-Tae, Jern, Patric, Jones, Matthew, Jurka, Jerzy, Kanamori, Hiroyuki, Kapetanovic, Ronan, Kim, Jaebum, Kim, Jae-Hwan, Kim, Kyu-Won, Kim, Tae-Hun, Larson, Greger, Lee, Kyooyeol, Lee, Kyung-Tai, Leggett, Richard, Lewin, Harris A., Li, Yingrui, Liu, Wansheng, Loveland, Jane E., Lu, Yao, Lunney, Joan K., Ma, Jian, Madsen, Ole, Mann, Katherine, Matthews, Lucy, McLaren, Stuart, Morozumi, Takeya, Murtaugh, Michael P., Narayan, Jitendra, Truong Nguyen, Dinh, Ni, Peixiang, Oh, Song-Jung, Onteru, Suneel, Panitz, Frank, Park, Eung-Woo, Park, Hong-Seog, Pascal, Geraldine, Paudel, Yogesh, Perez-Enciso, Miguel, Ramirez-Gonzalez, Ricardo, Reecy, James M., Rodriguez-Zas, Sandra, Rohrer, Gary A., Rund, Lauretta, Sang, Yongming, Schachtschneider, Kyle, Schraiber, Joshua G., Schwartz, John, Scobie, Linda, Scott, Carol, Searle, Stephen, Servin, Bertrand, Southey, Bruce R., Sperber, Goran, Stadler, Peter, Sweedler, Jonathan V., Tafer, Hakim, Thomsen, Bo, Wali, Rashmi, Wang, Jian, Wang, Jun, White, Simon, Xu, Xun, Yerle, Martine, Zhang, Guojie, Zhang, Jianguo, Zhang, Jie, Zhao, Shuhong, Rogers, Jane, Churcher, Carol, and Schook, Lawrence B.
Published: 2012
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19. An integrated encyclopedia of DNA elements in the human genome

Author: Dunham, Ian, Kundaje, Anshul, Aldred, Shelley F., Collins, Patrick J., Davis, Carrie A., Doyle, Francis, Epstein, Charles B., Frietze, Seth, Harrow, Jennifer, Kaul, Rajinder, Khatun, Jainab, Lajoie, Bryan R., Landt, Stephen G., Lee, Bum-Kyu, Pauli, Florencia, Rosenbloom, Kate R., Sabo, Peter, Safi, Alexias, Sanyal, Amartya, Shoresh, Noam, Simon, Jeremy M., Song, Lingyun, Trinklein, Nathan D., Altshuler, Robert C., Birney, Ewan, Brown, James B., Cheng, Chao, Djebali, Sarah, Dong, Xianjun, Ernst, Jason, Furey, Terrence S., Gerstein, Mark, Giardine, Belinda, Greven, Melissa, Hardison, Ross C., Harris, Robert S., Herrero, Javier, Hoffman, Michael M., Iyer, Sowmya, Kellis, Manolis, Kheradpour, Pouya, Lassmann, Timo, Li, Qunhua, Lin, Xinying, Marinov, Georgi K., Merkel, Angelika, Mortazavi, Ali, Parker, Stephen C. J., Reddy, Timothy E., Rozowsky, Joel, Schlesinger, Felix, Thurman, Robert E., Wang, Jie, Ward, Lucas D., Whitfield, Troy W., Wilder, Steven P., Wu, Weisheng, Xi, Hualin S., Yip, Kevin Y., Zhuang, Jiali, Bernstein, Bradley E., Green, Eric D., Gunter, Chris, Snyder, Michael, Pazin, Michael J., Lowdon, Rebecca F., Dillon, Laura A. L., Adams, Leslie B., Kelly, Caroline J., Zhang, Julia, Wexler, Judith R., Good, Peter J., Feingold, Elise A., Crawford, Gregory E., Dekker, Job, Elnitski, Laura, Farnham, Peggy J., Giddings, Morgan C., Gingeras, Thomas R., Guigo, Roderic, Hubbard, Timothy J., Kent, W. James, Lieb, Jason D., Margulies, Elliott H., Myers, Richard M., Stamatoyannopoulos, John A., Tenenbaum, Scott A., Weng, Zhiping, White, Kevin P., Wold, Barbara, Yu, Yanbao, Wrobel, John, Risk, Brian A., Gunawardena, Harsha P., Kuiper, Heather C., Maier, Christopher W., Xie, Ling, Chen, Xian, Mikkelsen, Tarjei S., Gillespie, Shawn, Goren, Alon, Ram, Oren, Zhang, Xiaolan, Wang, Li, Issner, Robbyn, Coyne, Michael J., Durham, Timothy, Ku, Manching, Truong, Thanh, Eaton, Matthew L., Dobin, Alex, Tanzer, Andrea, Lagarde, Julien, Lin, Wei, Xue, Chenghai, Williams, Brian A., Zaleski, Chris, Roder, Maik, Kokocinski, Felix, Abdelhamid, Rehab F., Alioto, Tyler, Antoshechkin, Igor, Baer, Michael T., Batut, Philippe, Bell, Ian, Bell, Kimberly, Chakrabortty, Sudipto, Chrast, Jacqueline, Curado, Joao, Derrien, Thomas, Drenkow, Jorg, Dumais, Erica, Dumais, Jackie, Duttagupta, Radha, Fastuca, Megan, Fejes-Toth, Kata, Ferreira, Pedro, Foissac, Sylvain, Fullwood, Melissa J., Gao, Hui, Gonzalez, David, Gordon, Assaf, Howald, Cedric, Jha, Sonali, Johnson, Rory, Kapranov, Philipp, King, Brandon, Kingswood, Colin, Li, Guoliang, Luo, Oscar J., Park, Eddie, Preall, Jonathan B., Presaud, Kimberly, Ribeca, Paolo, Robyr, Daniel, Ruan, Xiaoan, Sammeth, Michael, Sandhu, Kuljeet Singh, Schaeffer, Lorain, See, Lei-Hoon, Shahab, Atif, Skancke, Jorgen, Suzuki, Ana Maria, Takahashi, Hazuki, Tilgner, Hagen, Trout, Diane, Walters, Nathalie, Wang, Huaien, Hayashizaki, Yoshihide, Reymond, Alexandre, Antonarakis, Stylianos E., Hannon, Gregory J., Ruan, Yijun, Carninci, Piero, Sloan, Cricket A., Learned, Katrina, Malladi, Venkat S., Wong, Matthew C., Barber, Galt P., Cline, Melissa S., Dreszer, Timothy R., Heitner, Steven G., Karolchik, Donna, Kirkup, Vanessa M., Meyer, Laurence R., Long, Jeffrey C., Maddren, Morgan, Raney, Brian J., Grasfeder, Linda L., Giresi, Paul G., Battenhouse, Anna, Sheffield, Nathan C., Showers, Kimberly A., London, Darin, Bhinge, Akshay A., Shestak, Christopher, Schaner, Matthew R., Ki Kim, Seul, Zhang, Zhuzhu Z., Mieczkowski, Piotr A., Mieczkowska, Joanna O., Liu, Zheng, McDaniell, Ryan M., Ni, Yunyun, Rashid, Naim U., Kim, Min Jae, Adar, Sheera, Zhang, Zhancheng, Wang, Tianyuan, Winter, Deborah, Keefe, Damian, Iyer, Vishwanath R., Zheng, Meizhen, Wang, Ping, Gertz, Jason, Vielmetter, Jost, Partridge, E., Varley, Katherine E., Gasper, Clarke, Bansal, Anita, Pepke, Shirley, Jain, Preti, Amrhein, Henry, Bowling, Kevin M., Anaya, Michael, Cross, Marie K., Muratet, Michael A., Newberry, Kimberly M., McCue, Kenneth, Nesmith, Amy S., Fisher-Aylor, Katherine I., Pusey, Barbara, DeSalvo, Gilberto, Parker, Stephanie L., Balasubramanian, Sreeram, Davis, Nicholas S., Meadows, Sarah K., Eggleston, Tracy, Newberry, J. Scott, Levy, Shawn E., Absher, Devin M., Wong, Wing H., Blow, Matthew J., Visel, Axel, Pennachio, Len A., Petrykowska, Hanna M., Abyzov, Alexej, Aken, Bronwen, Barrell, Daniel, Barson, Gemma, Berry, Andrew, Bignell, Alexandra, Boychenko, Veronika, Bussotti, Giovanni, Davidson, Claire, Despacio-Reyes, Gloria, Diekhans, Mark, Ezkurdia, Iakes, Frankish, Adam, Gilbert, James, Gonzalez, Jose Manuel, Griffiths, Ed, Harte, Rachel, Hendrix, David A., Hunt, Toby, Jungreis, Irwin, Kay, Mike, Khurana, Ekta, Leng, Jing, Lin, Michael F., Loveland, Jane, Lu, Zhi, Manthravadi, Deepa, Mariotti, Marco, Mudge, Jonathan, Mukherjee, Gaurab, Notredame, Cedric, Pei, Baikang, Rodriguez, Jose Manuel, Saunders, Gary, Sboner, Andrea, Searle, Stephen, Sisu, Cristina, Snow, Catherine, Steward, Charlie, Tapanari, Electra, Tress, Michael L., van Baren, Marijke J., Washietl, Stefan, Wilming, Laurens, Zadissa, Amonida, Zhang, Zhengdong, Brent, Michael, Haussler, David, Valencia, Alfonso, Addleman, Nick, Alexander, Roger P., Auerbach, Raymond K., Balasubramanian, Suganthi, Bettinger, Keith, Bhardwaj, Nitin, Boyle, Alan P., Cao, Alina R., Cayting, Philip, Charos, Alexandra, Cheng, Yong, Eastman, Catharine, Euskirchen, Ghia, Fleming, Joseph D., Grubert, Fabian, Habegger, Lukas, Hariharan, Manoj, Harmanci, Arif, Iyengar, Sushma, Jin, Victor X., Karczewski, Konrad J., Kasowski, Maya, Lacroute, Phil, Lam, Hugo, Lamarre-Vincent, Nathan, Lian, Jin, Lindahl-Allen, Marianne, Min, Renqiang, Miotto, Benoit, Monahan, Hannah, Moqtaderi, Zarmik, Mu, Xinmeng J., Ouyang, Zhengqing, Patacsil, Dorrelyn, Raha, Debasish, Ramirez, Lucia, Reed, Brian, Shi, Minyi, Slifer, Teri, Witt, Heather, Wu, Linfeng, Xu, Xiaoqin, Yan, Koon-Kiu, Yang, Xinqiong, Struhl, Kevin, Weissman, Sherman M., Penalva, Luiz O., Karmakar, Subhradip, Bhanvadia, Raj R., Choudhury, Alina, Domanus, Marc, Ma, Lijia, Moran, Jennifer, Victorsen, Alec, Auer, Thomas, Centanin, Lazaro, Eichenlaub, Michael, Gruhl, Franziska, Heermann, Stephan, Hoeckendorf, Burkhard, Inoue, Daigo, Kellner, Tanja, Kirchmaier, Stephan, Mueller, Claudia, Reinhardt, Robert, Schertel, Lea, Schneider, Stephanie, Sinn, Rebecca, Wittbrodt, Beate, Wittbrodt, Jochen, Partridge, E. Christopher, Jain, Gaurav, Balasundaram, Gayathri, Bates, Daniel L., Byron, Rachel, Canfield, Theresa K., Diegel, Morgan J., Dunn, Douglas, Ebersol, Abigail K., Frum, Tristan, Garg, Kavita, Gist, Erica, Hansen, R. Scott, Boatman, Lisa, Haugen, Eric, Humbert, Richard, Johnson, Audra K., Johnson, Ericka M., Kutyavin, Tattyana V., Lee, Kristen, Lotakis, Dimitra, Maurano, Matthew T., Neph, Shane J., Neri, Fiedencio V., Nguyen, Eric D., Qu, Hongzhu, Reynolds, Alex P., Roach, Vaughn, Rynes, Eric, Sanchez, Minerva E., Sandstrom, Richard S., Shafer, Anthony O., Stergachis, Andrew B., Thomas, Sean, Vernot, Benjamin, Vierstra, Jeff, Vong, Shinny, Weaver, Molly A., Yan, Yongqi, Zhang, Miaohua, Akey, Joshua M., Bender, Michael, Dorschner, Michael O., Groudine, Mark, MacCoss, Michael J., Navas, Patrick, Stamatoyannopoulos, George, Beal, Kathryn, Brazma, Alvis, Flicek, Paul, Johnson, Nathan, Lukk, Margus, Luscombe, Nicholas M., Sobral, Daniel, Vaquerizas, Juan M., Batzoglou, Serafim, Sidow, Arend, Hussami, Nadine, Kyriazopoulou-Panagiotopoulou, Sofia, Libbrecht, Max W., Schaub, Marc A., Miller, Webb, Bickel, Peter J., Banfai, Balazs, Boley, Nathan P., Huang, Haiyan, Li, Jingyi Jessica, Noble, William Stafford, Bilmes, Jeffrey A., Buske, Orion J., Sahu, Avinash D., Kharchenko, Peter V., Park, Peter J., Baker, Dannon, Taylor, James, and Lochovsky, Lucas
Subjects: Genetic research, Human genome -- Research, Genetic transcription -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence variants linked to human disease, and can thereby guide interpretation of this variation. Overall, the project provides new insights into the organization and regulation of our genes and genome, and is an expansive resource of functional annotations for biomedical research., Author(s): The ENCODE Project Consortium; Overall coordination (data analysis coordination); Ian Dunham [2]; Anshul Kundaje [3, 82]; Data production leads (data production); Shelley F. Aldred [4]; Patrick J. Collins [4]; [...]
Published: 2012
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20. EVOLUTIONARY GENOMICS: Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication

Author: Carneiro, Miguel, Rubin, Carl-Johan, Di Palma, Federica, Albert, Frank W., Alföldi, Jessica, Barrio, Alvaro Martinez, Pielberg, Gerli, Rafati, Nima, Sayyab, Shumaila, Turner-Maier, Jason, Younis, Shady, Afonso, Sandra, Aken, Bronwen, Alves, Joel M., Barrell, Daniel, Bolet, Gerard, Boucher, Samuel, Burbano, Hernán A., Campos, Rita, Chang, Jean L., Duranthon, Veronique, Fontanesi, Luca, Garreau, Hervé, Heiman, David, Johnson, Jeremy, Mage, Rose G., Peng, Ze, Queney, Guillaume, Rogel-Gaillard, Claire, Ruffier, Magali, Searle, Steve, Villafuerte, Rafael, Xiong, Anqi, Young, Sarah, Forsberg-Nilsson, Karin, Good, Jeffrey M., Lander, Eric S., Ferrand, Nuno, Lindblad-Toh, Kerstin, and Andersson, Leif
Published: 2014
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21. Ensembl 2014

Author: Flicek, Paul, Amode, Ridwan M., Barrell, Daniel, Beal, Kathryn, Billis, Konstantinos, Brent, Simon, Carvalho-Silva, Denise, Clapham, Peter, Coates, Guy, Fitzgerald, Stephen, Gil, Laurent, Girón, Carlos García, Gordon, Leo, Hourlier, Thibaut, Hunt, Sarah, Johnson, Nathan, Juettemann, Thomas, Kähäri, Andreas K., Keenan, Stephen, Kulesha, Eugene, Martin, Fergal J., Maurel, Thomas, McLaren, William M., Murphy, Daniel N., Nag, Rishi, Overduin, Bert, Pignatelli, Miguel, Pritchard, Bethan, Pritchard, Emily, Riat, Harpreet S., Ruffier, Magali, Sheppard, Daniel, Taylor, Kieron, Thormann, Anja, Trevanion, Stephen J., Vullo, Alessandro, Wilder, Steven P., Wilson, Mark, Zadissa, Amonida, Aken, Bronwen L., Birney, Ewan, Cunningham, Fiona, Harrow, Jennifer, Herrero, Javier, Hubbard, Tim J.P., Kinsella, Rhoda, Muffato, Matthieu, Parker, Anne, Spudich, Giulietta, Yates, Andy, Zerbino, Daniel R., and Searle, Stephen M.J.
Published: 2014
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22. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

Author: Mikkelsen, Tarjei S., Wakefield, Matthew J., Aken, Bronwen, Amemiya, Chris T., Chang, Jean L., Duke, Shannon, Garber, Manuel, Gentles, Andrew J., Goodstadt, Leo, Heger, Andreas, Jurka, Jerzy, Kamal, Michael, Mauceli, Evan, Searle, Stephen M. J., Sharpe, Ted, Baker, Michelle L., Batzer, Mark A., Benos, Panayiotis V., Belov, Katherine, Clamp, Michele, Cook, April, Cuff, James, Das, Radhika, Davidow, Lance, Deakin, Janine E., Fazzari, Melissa J., Glass, Jacob L., Grabherr, Manfred, Greally, John M., Gu, Wanjun, Hore, Timothy A., Huttley, Gavin A., Kleber, Michael, Jirtle, Randy L., Koina, Edda, Lee, Jeannie T., Mahony, Shaun, Marra, Marco A., Miller, Robert D., Nicholls, Robert D., Oda, Mayumi, Papenfuss, Anthony T., Parra, Zuly E., Pollock, David D., Ray, David A., Schein, Jacqueline E., Speed, Terence P., Thompson, Katherine, VandeBerg, John L., Wade, Claire M., Walker, Jerilyn A., Waters, Paul D., Webber, Caleb, Weidman, Jennifer R., Xie, Xiaohui, Zody, Michael C., Baldwin, Jennifer, Abdouelleil, Amr, Abdulkadir, Jamal, Abebe, Adal, Abera, Brikti, Abreu, Justin, Acer, St Christophe, Aftuck, Lynne, Alexander, Allen, An, Peter, Anderson, Erica, Anderson, Scott, Arachi, Harindra, Azer, Marc, Bachantsang, Pasang, Barry, Andrew, Bayul, Tashi, Berlin, Aaron, Bessette, Daniel, Bloom, Toby, Blye, Jason, Boguslavskiy, Leonid, Bonnet, Claude, Boukhgalter, Boris, Bourzgui, Imane, Brown, Adam, Cahill, Patrick, Channer, Sheridon, Cheshatsang, Yama, Chuda, Lisa, Citroen, Mieke, Collymore, Alville, Cooke, Patrick, Costello, Maura, D'Aco, Katie, Daza, Riza, De Haan, Georgius, DeGray, Stuart, DeMaso, Christina, Dhargay, Norbu, Dooley, Kimberly, Dooley, Erin, Doricent, Missole, Dorje, Passang, Dorjee, Kunsang, Dupes, Alan, Elong, Richard, Falk, Jill, Farina, Abderrahim, Faro, Susan, Ferguson, Diallo, Fisher, Sheila, Foley, Chelsea D., Franke, Alicia, Friedrich, Dennis, Gadbois, Loryn, Gearin, Gary, Gearin, Christina R., Giannoukos, Georgia, Goode, Tina, Graham, Joseph, Grandbois, Edward, Grewal, Sharleen, Gyaltsen, Kunsang, Hafez, Nabil, Hagos, Birhane, Hall, Jennifer, Henson, Charlotte, Hollinger, Andrew, Honan, Tracey, Huard, Monika D., Hughes, Leanne, Hurhula, Brian, Husby, M. Erii, Kamat, Asha, Kanga, Ben, Kashin, Seva, Khazanovich, Dmitry, Kisner, Peter, Lance, Krista, Lara, Marcia, Lee, William, Lennon, Niall, Letendre, Frances, LeVine, Rosie, Lipovsky, Alex, Liu, Xiaohong, Liu, Jinlei, Liu, Shangtao, Lokyitsang, Tashi, Lokyitsang, Yeshi, Lubonja, Rakela, Lui, Annie, MacDonald, Pen, Magnisalis, Vasilia, Maru, Kebede, Matthews, Charles, McCusker, William, McDonough, Susan, Mehta, Teena, Meldrim, James, Meneus, Louis, Mihai, Oana, Mihalev, Atanas, Mihova, Tanya, Mittelman, Rachel, Mlenga, Valentine, Montmayeur, Anna, Mulrain, Leonidas, Navidi, Adam, Naylor, Jerome, Negash, Tamrat, Nguyen, Thu, Nguyen, Nga, Nicol, Robert, Norbu, Choe, Norbu, Nyima, Novod, Nathaniel, O'Neill, Barry, Osman, Sahal, Markiewicz, Eva, Oyono, Otero L., Patti, Christopher, Phunkhang, Pema, Pierre, Fritz, Priest, Margaret, Raghuraman, Sujaa, Rege, Filip, Reyes, Rebecca, Rise, Cecil, Rogov, Peter, Ross, Keenan, Ryan, Elizabeth, Settipalli, Sampath, Shea, Terry, Sherpa, Ngawang, Shi, Lu, Shih, Diana, Sparrow, Todd, Spaulding, Jessica, Stalker, John, Stange-Thomann, Nicole, Stavropoulos, Sharon, Stone, Catherine, Strader, Christopher, Tesfaye, Senait, Thomson, Talene, Thoulutsang, Yama, Thoulutsang, Dawa, Topham, Kerri, Topping, Ira, Tsamla, Tsamla, Vassiliev, Helen, Vo, Andy, Wangchuk, Tsering, Wangdi, Tsering, Weiand, Michael, Wilkinson, Jane, Wilson, Adam, Yadav, Shailendra, Young, Geneva, Yu, Qing, Zembek, Lisa, Zhong, Danni, Zimmer, Andrew, Zwirko, Zac, Jaffe, David B., Alvarez, Pablo, Brockman, Will, Butler, Jonathan, Chin, CheeWhye, Gnerre, Sante, MacCallum, Iain, Graves, Jennifer A. Marshall, Ponting, Chris P., Breen, Matthew, Samollow, Paul B., Lander, Eric S., and Lindblad-Toh, Kerstin
Subjects: Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Author(s): Tarjei S. Mikkelsen (corresponding author) [1, 2]; Matthew J. Wakefield [3]; Bronwen Aken [4]; Chris T. Amemiya [5]; Jean L. Chang [1]; Shannon Duke [6]; Manuel Garber [1]; Andrew [...]
Published: 2007
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23. The African coelacanth genome provides insights into tetrapod evolution

Author: Amemiya, Chris T., Alföldi, Jessica J, Lee, Alison P., Fan, Shaohua S, Philippe, Hervé H, MacCallum, Iain I, Braasch, Ingo I, Manousaki, Tereza T, Schneider, Igor I, Rohner, Nicolas N, Organ, Chris C, Chalopin, Domitille D, Smith, Jeramiah J., Robinson, Mark M, Dorrington, Rosemary A., Gerdol, Marco M, Aken, Bronwen B, Biscotti, Maria Assunta, Barucca, Marco M, Baurain, Denis D, Berlin, Aaron M., Blatch, Gregory L., Buonocore, Francesco F, Burmester, Thorsten T, Campbell, Michael S., Canapa, Adriana A, Cannon, John P., Christoffels, Alan A, De Moro, Gianluca G, Edkins, Adrienne L., Fan, Lin L, Fausto, Anna Maria, Feiner, Nathalie N, Forconi, Mariko M, Gamieldien, Junaid J, Gnerre, Sante S, Gnirke, Andreas A, Goldstone, Jared V., Haerty, Wilfried W, Hahn, Mark E., Hesse, Uljana U, Hoffmann, Steve S, Johnson, Jeremy J, Karchner, Sibel I., Kuraku, Shigehiro S, Lara, Marcia M, Levin, Joshua Z., Litman, Gary W., Mauceli, Evan E, Miyake, Tsutomu T, Mueller, Gail M., Nelson, David R., Nitsche, Anne A, Olmo, Ettore E, Ota, Tatsuya T, Pallavicini, Alberto A, Panji, Sumir S, Picone, Barbara B, Ponting, Chris P., Prohaska, Sonja J., Przybylski, Dariusz D, Saha, Nil Ratan, Ravi, Vydianathan V, Ribeiro, Filipe J., Sauka-Spengler, Tatjana T, Scapigliati, Giuseppe G, Searle, Stephen M. J., Sharpe, Ted T, Simakov, Oleg O, Stadler, Peter F., Stegeman, John J., Sumiyama, Kenta K, Tabbaa, Diana D, Tafer, Hakim H, Turner-Maier, Jason J, van Heusden, Peter P, White, Simon S, Williams, Louise L, Yandell, Mark M, Brinkmann, Henner H, Volff, Jean-Nicolas J, Tabin, Clifford J., Shubin, Neil N, Schartl, Manfred M, Jaffe, David B., Postlethwait, John H., Venkatesh, Byrappa B, Di Palma, Federica F, Lander, Eric S., Meyer, Axel A, and Lindblad-Toh, Kerstin K
Published: 2013
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24. Ensembl 2013

Author: Flicek, Paul, Ahmed, Ikhlak, Amode, Ridwan M., Barrell, Daniel, Beal, Kathryn, Brent, Simon, Carvalho-Silva, Denise, Clapham, Peter, Coates, Guy, Fairley, Susan, Fitzgerald, Stephen, Gil, Laurent, García-Girón, Carlos, Gordon, Leo, Hourlier, Thibaut, Hunt, Sarah, Juettemann, Thomas, Kähäri, Andreas K., Keenan, Stephen, Komorowska, Monika, Kulesha, Eugene, Longden, Ian, Maurel, Thomas, McLaren, William M., Muffato, Matthieu, Nag, Rishi, Overduin, Bert, Pignatelli, Miguel, Pritchard, Bethan, Pritchard, Emily, Riat, Harpreet Singh, Ritchie, Graham R. S., Ruffier, Magali, Schuster, Michael, Sheppard, Daniel, Sobral, Daniel, Taylor, Kieron, Thormann, Anja, Trevanion, Stephen, White, Simon, Wilder, Steven P., Aken, Bronwen L., Birney, Ewan, Cunningham, Fiona, Dunham, Ian, Harrow, Jennifer, Herrero, Javier, Hubbard, Tim J. P., Johnson, Nathan, Kinsella, Rhoda, Parker, Anne, Spudich, Giulietta, Yates, Andy, Zadissa, Amonida, and Searle, Stephen M. J.
Published: 2013
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25. Ensembl 2012

Author: Flicek, Paul, Amode, M. Ridwan, Barrell, Daniel, Beal, Kathryn, Brent, Simon, Carvalho-Silva, Denise, Clapham, Peter, Coates, Guy, Fairley, Susan, Fitzgerald, Stephen, Gil, Laurent, Gordon, Leo, Hendrix, Maurice, Hourlier, Thibaut, Johnson, Nathan, Kähäri, Andreas K., Keefe, Damian, Keenan, Stephen, Kinsella, Rhoda, Komorowska, Monika, Koscielny, Gautier, Kulesha, Eugene, Larsson, Pontus, Longden, Ian, McLaren, William, Muffato, Matthieu, Overduin, Bert, Pignatelli, Miguel, Pritchard, Bethan, Riat, Harpreet Singh, Ritchie, Graham R. S., Ruffier, Magali, Schuster, Michael, Sobral, Daniel, Tang, Y. Amy, Taylor, Kieron, Trevanion, Stephen, Vandrovcova, Jana, White, Simon, Wilson, Mark, Wilder, Steven P., Aken, Bronwen L., Birney, Ewan, Cunningham, Fiona, Dunham, Ian, Durbin, Richard, Fernández-Suarez, Xosé M., Harrow, Jennifer, Herrero, Javier, Hubbard, Tim J. P., Parker, Anne, Proctor, Glenn, Spudich, Giulietta, Vogel, Jan, Yates, Andy, Zadissa, Amonida, and Searle, Stephen M. J.
Published: 2012
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26. The genome sequence of Atlantic cod reveals a unique immune system

Author: Star, Bastiaan, Nederbragt, Alexander J., Jentoft, Sissel, Grimholt, Unni, Malmstrøm, Martin, Gregers, Tone F., Rounge, Trine B., Paulsen, Jonas, Solbakken, Monica H., Sharma, Animesh, Wetten, Ola F., Lanzén, Anders, Winer, Roger, Knight, James, Vogel, Jan-Hinnerk, Aken, Bronwen, Andersen, Øivind, Lagesen, Karin, Tooming-Klunderud, Ave, Edvardsen, Rolf B., Tina, Kirubakaran G., Espelund, Mari, Nepal, Chirag, Previti, Christopher, Karlsen, Bård Ove, Moum, Truls, Skage, Morten, Berg, Paul R., Gjøen, Tor, Kuhl, Heiner, Thorsen, Jim, Malde, Ketil, Reinhardt, Richard, Du, Lei, Johansen, Steinar D., Searle, Steve, Lien, Sigbjørn, Nilsen, Frank, Jonassen, Inge, Omholt, Stig W., Stenseth, Nils Chr., and Jakobsen, Kjetill S.
Published: 2011
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27. Ensembl 2011

Author: Flicek, Paul, Amode, M. Ridwan, Barrell, Daniel, Beal, Kathryn, Brent, Simon, Chen, Yuan, Clapham, Peter, Coates, Guy, Fairley, Susan, Fitzgerald, Stephen, Gordon, Leo, Hendrix, Maurice, Hourlier, Thibaut, Johnson, Nathan, Kähäri, Andreas, Keefe, Damian, Keenan, Stephen, Kinsella, Rhoda, Kokocinski, Felix, Kulesha, Eugene, Larsson, Pontus, Longden, Ian, McLaren, William, Overduin, Bert, Pritchard, Bethan, Riat, Harpreet Singh, Rios, Daniel, Ritchie, Graham R. S., Ruffier, Magali, Schuster, Michael, Sobral, Daniel, Spudich, Giulietta, Tang, Y. Amy, Trevanion, Stephen, Vandrovcova, Jana, Vilella, Albert J., White, Simon, Wilder, Steven P., Zadissa, Amonida, Zamora, Jorge, Aken, Bronwen L., Birney, Ewan, Cunningham, Fiona, Dunham, Ian, Durbin, Richard, Fernández-Suarez, Xosé M., Herrero, Javier, Hubbard, Tim J. P., Parker, Anne, Proctor, Glenn, Vogel, Jan, and Searle, Stephen M. J.
Published: 2011
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28. An improved pig reference genome sequence to enable pig genetics and genomics research

Author: Warr, Amanda, primary, Affara, Nabeel, primary, Aken, Bronwen, primary, Beiki, Hamid, primary, Bickhart, Derek M, primary, Billis, Konstantinos, primary, Chow, William, primary, Eory, Lel, primary, Finlayson, Heather A, primary, Flicek, Paul, primary, Girón, Carlos G, primary, Griffin, Darren K, primary, Hall, Richard, primary, Hannum, Greg, primary, Hourlier, Thibaut, primary, Howe, Kerstin, primary, Hume, David A, primary, Izuogu, Osagie, primary, Kim, Kristi, primary, Koren, Sergey, primary, Liu, Haibou, primary, Manchanda, Nancy, primary, Martin, Fergal J, primary, Nonneman, Dan J, primary, O'Connor, Rebecca E, primary, Phillippy, Adam M, primary, Rohrer, Gary A, primary, Rosen, Benjamin D, primary, Rund, Laurie A, primary, Sargent, Carole A, primary, Schook, Lawrence B, primary, Schroeder, Steven G, primary, Schwartz, Ariel S, primary, Skinner, Ben M, primary, Talbot, Richard, primary, Tseng, Elizabeth, primary, Tuggle, Christopher K, primary, Watson, Mick, primary, Smith, Timothy P L, primary, and Archibald, Alan L, primary
Published: 2020
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29. Ensembl’s 10th year

Author: Flicek, Paul, Aken, Bronwen L., Ballester, Benoit, Beal, Kathryn, Bragin, Eugene, Brent, Simon, Chen, Yuan, Clapham, Peter, Coates, Guy, Fairley, Susan, Fitzgerald, Stephen, Fernandez-Banet, Julio, Gordon, Leo, Gräf, Stefan, Haider, Syed, Hammond, Martin, Howe, Kerstin, Jenkinson, Andrew, Johnson, Nathan, Kähäri, Andreas, Keefe, Damian, Keenan, Stephen, Kinsella, Rhoda, Kokocinski, Felix, Koscielny, Gautier, Kulesha, Eugene, Lawson, Daniel, Longden, Ian, Massingham, Tim, McLaren, William, Megy, Karine, Overduin, Bert, Pritchard, Bethan, Rios, Daniel, Ruffier, Magali, Schuster, Michael, Slater, Guy, Smedley, Damian, Spudich, Giulietta, Tang, Y. Amy, Trevanion, Stephen, Vilella, Albert, Vogel, Jan, White, Simon, Wilder, Steven P., Zadissa, Amonida, Birney, Ewan, Cunningham, Fiona, Dunham, Ian, Durbin, Richard, Fernández-Suarez, Xosé M., Herrero, Javier, Hubbard, Tim J., Parker, Anne, Proctor, Glenn, Smith, James, and Searle, Stephen M.
Published: 2010
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30. The comparative genomics and complex population history of Papio baboons

Author: National Institutes of Health (US), Austrian Science Fund, Vienna Science and Technology Fund, Wellcome Trust, VEGA Agency (Slovakia), Fundación la Caixa, National Science Foundation (US), National Geographic Society, Leakey Foundation, Howard Hughes Medical Institute, Ministerio de Economía y Competitividad (España), European Commission, Rogers, Jeffrey, Raveendran, Muthuswamy, Alan Harris, R., Mailund, Thomas, Leppälä, Kalle, Athanasiadis, Georgios, Schierup, Mikkel Heide, Cheng, Jade, Munch, Kasper, Walker, Jerilyn A., Konkel, Miriam K., Jordan, Vallmer, Steely, Cody J., Beckstrom, Thomas O., Bergey, Christina, Burrell, Andrew, Schrempf, Dominik, Noll, Angela, Kothe, Maximillian, Kopp, Gisela H., Liu, Yue, Murali, Swetha, Billis, Konstantinos, Martin, Fergal J., Muffato, Matthieu, Cox, Laura, Else, James, Disotell, Todd, Muzny, Donna M., Phillips-Conroy, Jane, Aken, Bronwen, Eichler, Evan E., Marqués-Bonet, Tomàs, Kosiol, Carolin, Batzer, Mark A., Hahn, Matthiew W., Tung, Jenny, Zinner, Dietmar, Roos, Christian, Jolly, Clifford J., Gibbs, Richard A., Worley, Kim C., National Institutes of Health (US), Austrian Science Fund, Vienna Science and Technology Fund, Wellcome Trust, VEGA Agency (Slovakia), Fundación la Caixa, National Science Foundation (US), National Geographic Society, Leakey Foundation, Howard Hughes Medical Institute, Ministerio de Economía y Competitividad (España), European Commission, Rogers, Jeffrey, Raveendran, Muthuswamy, Alan Harris, R., Mailund, Thomas, Leppälä, Kalle, Athanasiadis, Georgios, Schierup, Mikkel Heide, Cheng, Jade, Munch, Kasper, Walker, Jerilyn A., Konkel, Miriam K., Jordan, Vallmer, Steely, Cody J., Beckstrom, Thomas O., Bergey, Christina, Burrell, Andrew, Schrempf, Dominik, Noll, Angela, Kothe, Maximillian, Kopp, Gisela H., Liu, Yue, Murali, Swetha, Billis, Konstantinos, Martin, Fergal J., Muffato, Matthieu, Cox, Laura, Else, James, Disotell, Todd, Muzny, Donna M., Phillips-Conroy, Jane, Aken, Bronwen, Eichler, Evan E., Marqués-Bonet, Tomàs, Kosiol, Carolin, Batzer, Mark A., Hahn, Matthiew W., Tung, Jenny, Zinner, Dietmar, Roos, Christian, Jolly, Clifford J., Gibbs, Richard A., and Worley, Kim C.
Abstract: Recent studies suggest that closely related species can accumulate substantial genetic and phenotypic differences despite ongoing gene flow, thus challenging traditional ideas regarding the genetics of speciation. Baboons (genus Papio) are Old World monkeys consisting of six readily distinguishable species. Baboon species hybridize in the wild, and prior data imply a complex history of differentiation and introgression. We produced a reference genome assembly for the olive baboon (Papio anubis) and whole-genome sequence data for all six extant species. We document multiple episodes of admixture and introgression during the radiation of Papio baboons, thus demonstrating their value as a model of complex evolutionary divergence, hybridization, and reticulation. These results help inform our understanding of similar cases, including modern humans, Neanderthals, Denisovans, and other ancient hominins.
Published: 2019

31. An improved pig reference genome sequence to enable pig genetics and genomics research

Author: Warr, Amanda, primary, Affara, Nabeel, additional, Aken, Bronwen, additional, Beiki, H., additional, Bickhart, Derek M., additional, Billis, Konstantinos, additional, Chow, William, additional, Eory, Lel, additional, Finlayson, Heather A., additional, Flicek, Paul, additional, Girón, Carlos G., additional, Griffin, Darren K., additional, Hall, Richard, additional, Hannum, Greg, additional, Hourlier, Thibaut, additional, Howe, Kerstin, additional, Hume, David A., additional, Izuogu, Osagie, additional, Kim, Kristi, additional, Koren, Sergey, additional, Liu, Haibou, additional, Manchanda, Nancy, additional, Martin, Fergal J., additional, Nonneman, Dan J., additional, O’Connor, Rebecca E., additional, Phillippy, Adam M., additional, Rohrer, Gary A., additional, Rosen, Benjamin D., additional, Rund, Laurie A., additional, Sargent, Carole A., additional, Schook, Lawrence B., additional, Schroeder, Steven G., additional, Schwartz, Ariel S., additional, Skinner, Ben M., additional, Talbot, Richard, additional, Tseng, Elizabeth, additional, Tuggle, Christopher K., additional, Watson, Mick, additional, Smith, Timothy P. L., additional, and Archibald, Alan L., additional
Published: 2019
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32. Selection of canonical transcripts for protein-coding genes

Author: Murphy, Daniel N, Martin, Fergal J, Aken, Bronwen, Ruffier, Magali, Laird, Matthew, and Cunningham, Fiona
Published: 2017
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33. Expanded encyclopaedias of DNA elements in the human and mouse genomes.

Author: The ENCODE Project Consortium, Abascal, Federico, Acosta, Reyes, Addleman, Nicholas J., Adrian, Jessika, Afzal, Veena, Aken, Bronwen, Akiyama, Jennifer A., Jammal, Omar Al, Amrhein, Henry, Anderson, Stacie M., Andrews, Gregory R., Antoshechkin, Igor, Ardlie, Kristin G., Armstrong, Joel, Astley, Matthew, Banerjee, Budhaditya, Barkal, Amira A., Barnes, If H. A., and Barozzi, Iros
Abstract: The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development. All data are available through the ENCODE data portal (https://www.encodeproject.org), including phase II ENCODE1 and Roadmap Epigenomics2 data. We have developed a registry of 926,535 human and 339,815 mouse candidate cis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN; http://screen.encodeproject.org) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the organization and function of the human and mouse genomes. The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes. [ABSTRACT FROM AUTHOR]
Published: 2020
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34. Perspectives on ENCODE.

Author: The ENCODE Project Consortium, Abascal, Federico, Acosta, Reyes, Addleman, Nicholas J., Adrian, Jessika, Afzal, Veena, Aken, Bronwen, Akiyama, Jennifer A., Jammal, Omar Al, Amrhein, Henry, Anderson, Stacie M., Andrews, Gregory R., Antoshechkin, Igor, Ardlie, Kristin G., Armstrong, Joel, Astley, Matthew, Banerjee, Budhaditya, Barkal, Amira A., Barnes, If H. A., and Barozzi, Iros
Abstract: The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community. The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases. [ABSTRACT FROM AUTHOR]
Published: 2020
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35. Ensembl 2019

Author: Cunningham, Fiona, primary, Achuthan, Premanand, additional, Akanni, Wasiu, additional, Allen, James, additional, Amode, M Ridwan, additional, Armean, Irina M, additional, Bennett, Ruth, additional, Bhai, Jyothish, additional, Billis, Konstantinos, additional, Boddu, Sanjay, additional, Cummins, Carla, additional, Davidson, Claire, additional, Dodiya, Kamalkumar Jayantilal, additional, Gall, Astrid, additional, Girón, Carlos García, additional, Gil, Laurent, additional, Grego, Tiago, additional, Haggerty, Leanne, additional, Haskell, Erin, additional, Hourlier, Thibaut, additional, Izuogu, Osagie G, additional, Janacek, Sophie H, additional, Juettemann, Thomas, additional, Kay, Mike, additional, Laird, Matthew R, additional, Lavidas, Ilias, additional, Liu, Zhicheng, additional, Loveland, Jane E, additional, Marugán, José C, additional, Maurel, Thomas, additional, McMahon, Aoife C, additional, Moore, Benjamin, additional, Morales, Joannella, additional, Mudge, Jonathan M, additional, Nuhn, Michael, additional, Ogeh, Denye, additional, Parker, Anne, additional, Parton, Andrew, additional, Patricio, Mateus, additional, Abdul Salam, Ahamed Imran, additional, Schmitt, Bianca M, additional, Schuilenburg, Helen, additional, Sheppard, Dan, additional, Sparrow, Helen, additional, Stapleton, Eloise, additional, Szuba, Marek, additional, Taylor, Kieron, additional, Threadgold, Glen, additional, Thormann, Anja, additional, Vullo, Alessandro, additional, Walts, Brandon, additional, Winterbottom, Andrea, additional, Zadissa, Amonida, additional, Chakiachvili, Marc, additional, Frankish, Adam, additional, Hunt, Sarah E, additional, Kostadima, Myrto, additional, Langridge, Nick, additional, Martin, Fergal J, additional, Muffato, Matthieu, additional, Perry, Emily, additional, Ruffier, Magali, additional, Staines, Daniel M, additional, Trevanion, Stephen J, additional, Aken, Bronwen L, additional, Yates, Andrew D, additional, Zerbino, Daniel R, additional, and Flicek, Paul, additional
Published: 2018
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36. GENCODE reference annotation for the human and mouse genomes

Author: Frankish, Adam, primary, Diekhans, Mark, additional, Ferreira, Anne-Maud, additional, Johnson, Rory, additional, Jungreis, Irwin, additional, Loveland, Jane, additional, Mudge, Jonathan M, additional, Sisu, Cristina, additional, Wright, James, additional, Armstrong, Joel, additional, Barnes, If, additional, Berry, Andrew, additional, Bignell, Alexandra, additional, Carbonell Sala, Silvia, additional, Chrast, Jacqueline, additional, Cunningham, Fiona, additional, Di Domenico, Tomás, additional, Donaldson, Sarah, additional, Fiddes, Ian T, additional, García Girón, Carlos, additional, Gonzalez, Jose Manuel, additional, Grego, Tiago, additional, Hardy, Matthew, additional, Hourlier, Thibaut, additional, Hunt, Toby, additional, Izuogu, Osagie G, additional, Lagarde, Julien, additional, Martin, Fergal J, additional, Martínez, Laura, additional, Mohanan, Shamika, additional, Muir, Paul, additional, Navarro, Fabio C P, additional, Parker, Anne, additional, Pei, Baikang, additional, Pozo, Fernando, additional, Ruffier, Magali, additional, Schmitt, Bianca M, additional, Stapleton, Eloise, additional, Suner, Marie-Marthe, additional, Sycheva, Irina, additional, Uszczynska-Ratajczak, Barbara, additional, Xu, Jinuri, additional, Yates, Andrew, additional, Zerbino, Daniel, additional, Zhang, Yan, additional, Aken, Bronwen, additional, Choudhary, Jyoti S, additional, Gerstein, Mark, additional, Guigó, Roderic, additional, Hubbard, Tim J P, additional, Kellis, Manolis, additional, Paten, Benedict, additional, Reymond, Alexandre, additional, Tress, Michael L, additional, and Flicek, Paul, additional
Published: 2018
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37. Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes

Author: Thybert, David, primary, Roller, Maša, additional, Navarro, Fábio C.P., additional, Fiddes, Ian, additional, Streeter, Ian, additional, Feig, Christine, additional, Martin-Galvez, David, additional, Kolmogorov, Mikhail, additional, Janoušek, Václav, additional, Akanni, Wasiu, additional, Aken, Bronwen, additional, Aldridge, Sarah, additional, Chakrapani, Varshith, additional, Chow, William, additional, Clarke, Laura, additional, Cummins, Carla, additional, Doran, Anthony, additional, Dunn, Matthew, additional, Goodstadt, Leo, additional, Howe, Kerstin, additional, Howell, Matthew, additional, Josselin, Ambre-Aurore, additional, Karn, Robert C., additional, Laukaitis, Christina M., additional, Jingtao, Lilue, additional, Martin, Fergal, additional, Muffato, Matthieu, additional, Nachtweide, Stefanie, additional, Quail, Michael A., additional, Sisu, Cristina, additional, Stanke, Mario, additional, Stefflova, Klara, additional, Van Oosterhout, Cock, additional, Veyrunes, Frederic, additional, Ward, Ben, additional, Yang, Fengtang, additional, Yazdanifar, Golbahar, additional, Zadissa, Amonida, additional, Adams, David J., additional, Brazma, Alvis, additional, Gerstein, Mark, additional, Paten, Benedict, additional, Pham, Son, additional, Keane, Thomas M., additional, Odom, Duncan T., additional, and Flicek, Paul, additional
Published: 2018
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38. Corrigendum: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

Author: Braasch, Ingo, Gehrke, Andrew R., Smith, Jeramiah J., Kawasaki, Kazuhiko, Manousaki, Tereza, Pasquier, Jérémy, Amores, Angel, Desvignes, Thomas, Batzel, Peter, Catchen, Julian, Berlin, Aaron M., Campbell, Michael S., Barrell, Daniel, Martin, Kyle J., Mulley, John F., Ravi, Vydianathan, Lee, Alison P., Nakamura, Tetsuya, Chalopin, Domitille, Fan, Shaohua, Wcisel, Dustin, Cañestro, Cristian, Sydes, Jason, Beaudry, Felix E.G., Sun, Yi, Hertel, Jana, Beam, Michael J., Fasold, Mario, Ishiyama, Mikio, Johnson, Jeremy, Kehr, Steffi, Lara, Marcia, Letaw, John H., Litman, Gary W., Litman, Ronda T., Mikami, Masato, Ota, Tatsuya, Saha, Nil Ratan, Williams, Louise, Stadler, Peter F., Wang, Han, Taylor, John S., Fontenot, Quenton, Ferrara, Allyse, Searle, Stephen M.J., Aken, Bronwen, Yandell, Mark, Schneider, Igor, Yoder, Jeffrey A, Volff, Jean-Nicolas, Meyer, Axel, Amemiya, Chris T, Venkatesh, Byrappa, Holland, Peter W.H., Guiguen, Yann, Bobe, Julien, Shubin, Neil H., Di Palma, Federica, Alföldi, Jessica, Lindblad-Toh, Kerstin, Postlethwait, John H., Institute of Neuroscience, National Research Council [Italy] (CNR), Department of Integrative Biology [Berkeley] (IB), University of California [Berkeley], University of California-University of California, Department of Organismal Biology and Anatomy, University of Chicago, Department of Biology, Northern Arizona University [Flagstaff], Department of Anthropology, University of California, Pennsylvania State University (Penn State), Penn State System, Hellenic Centre for Marine Research, Hellenic Center for Marine Research (HCMR), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Animal Biology, University of Pennsylvania [Philadelphia], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Eccles Institute of Human Genetics, University of Utah, Cold Spring Harbor, Cold Spring Harbor Laboratory, Wellcome Trust Genome Campus, The Wellcome Trust Sanger Institute [Cambridge], European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Department of Zoology, Auburn University (AU), Department of Animal and Plant Sciences [Sheffield], University of Sheffield [Sheffield], School of Biological Sciences [Bangor], Bangor University, Comparative Genomics Laboratory, Agency for Science, Technology and Research (A*STAR), International Institute of Molecular and Cell Biology, Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Department of Genetics, The University of Texas M.D. Anderson Cancer Center [Houston], Department of Molecular Biomedical Sciences Raleigh, North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC)-University of North Carolina System (UNC), Center for Comparative Medicine and Translational Research Raleigh, Departament de Genètica, Universitat Autònoma de Barcelona [Barcelona] (UAB), Institut de Recerca de la Biodiversitat, University of Barcelona, University of Victoria, Center for Circadian Clocks, Soochow University, School of Biology and Basic Medical Sciences, Medical College, Bioinformatics Group, Department of Computer Science, Universität Leipzig [Leipzig], Young Investigators Group Bioinformatics and Transcriptomics, Department of Proteomics, Helmholtz Centre for Environmental Research (UFZ), Department of Dental Hygiene, Nippon Dental University, Morsani College of Medicine, Department of Pediatrics, University of South Florida (USF), Department of Microbiology, Department of Evolutionary Studies of Biosystems, SOKENDAI, Graduate University for Advanced Studies, Molecular Genetics Program, Benaroya Research Institute, Department of Biological Sciences, The Open University [Milton Keynes] (OU), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, European Bioinformatics Institute, Instituto de Ciências Biológicas, Federal University of Para - Universidade Federal do Para [Belem - Brésil], Department of Molecular Biomedical Sciences, University of North Carolina System (UNC)-University of North Carolina System (UNC)-College of Veterinary Medicine Raleigh, Center for Comparative Medicine and Translational Research, International Max Planck Research School for Organismal Biology (IMPRS), University of Konstanz, Genome Analysis Center, Vertebrate and Health Genomics, Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Recherche Agronomique (INRA), Hellenic Centre for Marine Research (HCMR), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), Universitat Autònoma de Barcelona (UAB), University of Victoria [Canada] (UVIC), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), University of South Florida [Tampa] (USF), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), University of California (UC), University of Pennsylvania, École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Universität Leipzig, and Federal University of Para - Universidade Federal do Pará - UFPA [Belém, Brazil] (UFPA)
Subjects: [SDV]Life Sciences [q-bio], analyse phylogénétique, reproduction, poisson, analyse génomique, human, chromosome, analyse du transcriptome, genome, duplication des génomes, miRNA, fish, teleost, physiologie animale, séquence régulatrice, vertébré, homme, lepisosteus oculatus, interaction animal homme, lépisosté tacheté, évolution du génome, fonction des gènes, teleosteen, regulatory sequence, vertebrates, immunité, expression des gènes
Abstract: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons (vol 48, pg 427, 2016); As we intended, other researchers have been able to use the draft spotted gar genome sequence available from the Broad Institute website since December 2011, the assembly LepOcu1 publicly available from NCBI since 13 January 2012 under accession code GCA000242695.1, and the Ensembl gene annotation (version 74, December 2013; http://www.ensembl.org/Lepisosteus_oculatus/Info/Annotation) and recent annotation by NCBI on 15 May 2014 guided by RNA sequence data from ten tissues. While this article was in review, a paper (Nature 526, 108–111, 2015) was published that arrives at conclusions similar to some of our own analyses, and we wish to acknowledge that publication, which used our unpublished data and genome annotations, emphasizing the importance of the strategy of early release of sequence data. The correction has been made to the HTML and PDF versions of the article.
Published: 2016

39. Ensembl 2018

Author: Zerbino, Daniel R, primary, Achuthan, Premanand, additional, Akanni, Wasiu, additional, Amode, M Ridwan, additional, Barrell, Daniel, additional, Bhai, Jyothish, additional, Billis, Konstantinos, additional, Cummins, Carla, additional, Gall, Astrid, additional, Girón, Carlos García, additional, Gil, Laurent, additional, Gordon, Leo, additional, Haggerty, Leanne, additional, Haskell, Erin, additional, Hourlier, Thibaut, additional, Izuogu, Osagie G, additional, Janacek, Sophie H, additional, Juettemann, Thomas, additional, To, Jimmy Kiang, additional, Laird, Matthew R, additional, Lavidas, Ilias, additional, Liu, Zhicheng, additional, Loveland, Jane E, additional, Maurel, Thomas, additional, McLaren, William, additional, Moore, Benjamin, additional, Mudge, Jonathan, additional, Murphy, Daniel N, additional, Newman, Victoria, additional, Nuhn, Michael, additional, Ogeh, Denye, additional, Ong, Chuang Kee, additional, Parker, Anne, additional, Patricio, Mateus, additional, Riat, Harpreet Singh, additional, Schuilenburg, Helen, additional, Sheppard, Dan, additional, Sparrow, Helen, additional, Taylor, Kieron, additional, Thormann, Anja, additional, Vullo, Alessandro, additional, Walts, Brandon, additional, Zadissa, Amonida, additional, Frankish, Adam, additional, Hunt, Sarah E, additional, Kostadima, Myrto, additional, Langridge, Nicholas, additional, Martin, Fergal J, additional, Muffato, Matthieu, additional, Perry, Emily, additional, Ruffier, Magali, additional, Staines, Dan M, additional, Trevanion, Stephen J, additional, Aken, Bronwen L, additional, Cunningham, Fiona, additional, Yates, Andrew, additional, and Flicek, Paul, additional
Published: 2017
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40. Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation

Author: Pujar, Shashikant, primary, O’Leary, Nuala A, additional, Farrell, Catherine M, additional, Loveland, Jane E, additional, Mudge, Jonathan M, additional, Wallin, Craig, additional, Girón, Carlos G, additional, Diekhans, Mark, additional, Barnes, If, additional, Bennett, Ruth, additional, Berry, Andrew E, additional, Cox, Eric, additional, Davidson, Claire, additional, Goldfarb, Tamara, additional, Gonzalez, Jose M, additional, Hunt, Toby, additional, Jackson, John, additional, Joardar, Vinita, additional, Kay, Mike P, additional, Kodali, Vamsi K, additional, Martin, Fergal J, additional, McAndrews, Monica, additional, McGarvey, Kelly M, additional, Murphy, Michael, additional, Rajput, Bhanu, additional, Rangwala, Sanjida H, additional, Riddick, Lillian D, additional, Seal, Ruth L, additional, Suner, Marie-Marthe, additional, Webb, David, additional, Zhu, Sophia, additional, Aken, Bronwen L, additional, Bruford, Elspeth A, additional, Bult, Carol J, additional, Frankish, Adam, additional, Murphy, Terence, additional, and Pruitt, Kim D, additional
Published: 2017
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41. Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes

Author: Thybert, David, primary, Roller, Maša, additional, Navarro, Fábio C.P., additional, Fiddes, Ian, additional, Streeter, Ian, additional, Feig, Christine, additional, Martin-Galvez, David, additional, Kolmogorov, Mikhail, additional, Janoušek, Václav, additional, Akanni, Wasiu, additional, Aken, Bronwen, additional, Aldridge, Sarah, additional, Chakrapani, Varshith, additional, Chow, William, additional, Clarke, Laura, additional, Cummins, Carla, additional, Doran, Anthony, additional, Dunn, Matthew, additional, Goodstadt, Leo, additional, Howe, Kerstin, additional, Howell, Matthew, additional, Josselin, Ambre-Aurore, additional, Karn, Robert C., additional, Laukaitis, Christina M., additional, Jingtao, Lilue, additional, Martin, Fergal, additional, Muffato, Matthieu, additional, Quail, Michael A., additional, Sisu, Cristina, additional, Stanke, Mario, additional, Stefflova, Klara, additional, Oosterhout, Cock Van, additional, Veyrunes, Frederic, additional, Ward, Ben, additional, Yang, Fengtang, additional, Yazdanifar, Golbahar, additional, Zadissa, Amonida, additional, Adams, David, additional, Brazma, Alvis, additional, Gerstein, Mark, additional, Paten, Benedict, additional, Pham, Son, additional, Keane, Thomas, additional, Odom, Duncan T, additional, and Flicek, Paul, additional
Published: 2017
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42. Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate

Author: Jasinska, Anna J., primary, Zelaya, Ivette, additional, Service, Susan K., additional, Peterson, Christine B., additional, Cantor, Rita M., additional, Choi, Oi-Wa, additional, DeYoung, Joseph, additional, Eskin, Eleazar, additional, Fairbanks, Lynn A., additional, Fears, Scott, additional, Furterer, Allison E., additional, Huang, Yu S., additional, Ramensky, Vasily, additional, Schmitt, Christopher A., additional, Svardal, Hannes, additional, Jorgensen, Matthew J., additional, Kaplan, Jay R., additional, Villar, Diego, additional, Aken, Bronwen L., additional, Flicek, Paul, additional, Nag, Rishi, additional, Wong, Emily S., additional, Blangero, John, additional, Dyer, Thomas D., additional, Bogomolov, Marina, additional, Benjamini, Yoav, additional, Weinstock, George M., additional, Dewar, Ken, additional, Sabatti, Chiara, additional, Wilson, Richard K., additional, Jentsch, J. David, additional, Warren, Wesley, additional, Coppola, Giovanni, additional, Woods, Roger P., additional, and Freimer, Nelson B., additional
Published: 2016
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43. Avianbase:a community resource for bird genomics

Author: Eory, Lel, Gilbert, M Thomas P, Li, Cai, Li, Bo, Archibald, Alan, Aken, Bronwen L, Zhang, Guojie, Jarvis, Erich, Flicek, Paul, and Burt, David W
Abstract: Giving access to sequence and annotation data for genome assemblies is important because, while facilitating research, it places both assembly and annotation quality under scrutiny, resulting in improvements to both. Therefore we announce Avianbase, a resource for bird genomics, which provides access to data released by the Avian Phylogenomics Consortium.
Published: 2015

44. Divergence in gene expression within and between two closely related flycatcher species

Author: Uebbing, Severin, Künstner, Axel, Mäkinen, Hannu, Backström, Niclas, Bolivar, Paulina, Burri, Reto, Dutoit, Ludovic, Mugal, Carina F., Nater, Alexander, Aken, Bronwen, Flicek, Paul, Martin, Fergal J, Searle, Stephen M J, Ellegren, Hans, Uebbing, Severin, Künstner, Axel, Mäkinen, Hannu, Backström, Niclas, Bolivar, Paulina, Burri, Reto, Dutoit, Ludovic, Mugal, Carina F., Nater, Alexander, Aken, Bronwen, Flicek, Paul, Martin, Fergal J, Searle, Stephen M J, and Ellegren, Hans
Abstract: Relatively little is known about the character of gene expression evolution as species diverge. It is for instance unclear if gene expression generally evolves in a clock-like manner (by stabilizing selection or neutral evolution) or if there are frequent episodes of directional selection. To gain insights into the evolutionary divergence of gene expression, we sequenced and compared the transcriptomes of multiple organs from population samples of collared (Ficedula albicollis) and pied flycatchers (F. hypoleuca), two species which diverged less than one million years ago. Ordination analysis separated samples by organ rather than by species. Organs differed in their degrees of expression variance within species and expression divergence between species. Variance was negatively correlated with expression breadth and protein interactivity, suggesting that pleiotropic constraints reduce gene expression variance within species. Variance was correlated with between-species divergence, consistent with a pattern expected from stabilizing selection and neutral evolution. Using an expression PST approach, we identified genes differentially expressed between species and found 16 genes uniquely expressed in one of the species. For one of these, DPP7, uniquely expressed in collared flycatcher, the absence of expression in pied flycatcher could be associated with a ≈ 20 kb deletion including 11 out of 13 exons. This study of a young vertebrate speciation model system expands our knowledge of how gene expression evolves as natural populations become reproductively isolated.
Published: 2016
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45. The Ensembl gene annotation system

Author: Aken, Bronwen L., Ayling, Sarah, Barrell, Daniel, Clarke, Laura, Curwen, Valery, Fairley, Susan, Banet, Julio Fernandez, Billis, Konstantinos, Giron, Carlos Garcia, Hourlier, Thibaut, Howe, Kevin, Kähäri, Andreas, Kokocinski, Felix, Martin, Fergal J., Murphy, Daniel N., Nag, Rishi, Ruffier, Magali, Schuster, Michael, Tang, Y. Amy, Vogel, Jan-Hinnerk, White, Simon, Zadissa, Amonida, Flicek, Paul, Searle, Stephen M. J., Aken, Bronwen L., Ayling, Sarah, Barrell, Daniel, Clarke, Laura, Curwen, Valery, Fairley, Susan, Banet, Julio Fernandez, Billis, Konstantinos, Giron, Carlos Garcia, Hourlier, Thibaut, Howe, Kevin, Kähäri, Andreas, Kokocinski, Felix, Martin, Fergal J., Murphy, Daniel N., Nag, Rishi, Ruffier, Magali, Schuster, Michael, Tang, Y. Amy, Vogel, Jan-Hinnerk, White, Simon, Zadissa, Amonida, Flicek, Paul, and Searle, Stephen M. J.
Abstract: The Ensembl gene annotation system has been used to annotate over 70 different vertebrate species across a wide range of genome projects. Furthermore, it generates the automatic alignment-based annotation for the human and mouse GENCODE gene sets. The system is based on the alignment of biological sequences, including cDNAs, proteins and RNA-seq reads, to the target genome in order to construct candidate transcript models. Careful assessment and filtering of these candidate transcripts ultimately leads to the final gene set, which is made available on the Ensembl website. Here, we describe the annotation process in detail.
Published: 2016
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46. The consensus coding sequence (CCDS) project: identifying a common protein-coding gene set for the human and mouse genomes

Author: Pruitt, Kim D., Harrow, Jennifer, Harte, Rachel A., Wallin, Craig, Diekhans, Mark, Maglott, Donna R., Searle, Steve, Farrell, Catherine M., Loveland, Jane E., Ruef, Barbara J., Hart, Elizabeth, Suner, Marie-Marthe, Landrum, Melissa J., Aken, Bronwen, Ayling, Sarah, Baertsch, Robert, Fernandez-Banet, Julio, Cherry,Joshua L., Curwen, Val, DiCuccio, Michael, Kellis, Manolis, Lee, Jennifer, Lin, Michael F., Schuster, Michael, Shkeda, Andrew, Amid, Clara, Brown, Garth, Dukhanina, Oksana, Frankish, Adam, Hart, Jennifer, Maidak, Bonnie L., Mudge, Jonathan, Murphy, Michael R., Murphy, Terence, Rajan, Jeena, Rajput, Bhanu, Riddick, Lillian D., Snow, Catherine, Steward, Charles, Webb, David, Weber, Janet A., Wilming, Laurens, Wenyu Wu, Birney, Ewan, Haussler, David, Hubbard, Tim, Ostell, James, Durbin, Richard, and Lipman, David
Subjects: Human genome -- Research, Genetic code -- Research, Protein biosynthesis -- Analysis, Mice -- Genetic aspects, Health
Published: 2009

47. Ensembl 2017

Author: Aken, Bronwen L., primary, Achuthan, Premanand, additional, Akanni, Wasiu, additional, Amode, M. Ridwan, additional, Bernsdorff, Friederike, additional, Bhai, Jyothish, additional, Billis, Konstantinos, additional, Carvalho-Silva, Denise, additional, Cummins, Carla, additional, Clapham, Peter, additional, Gil, Laurent, additional, Girón, Carlos García, additional, Gordon, Leo, additional, Hourlier, Thibaut, additional, Hunt, Sarah E., additional, Janacek, Sophie H., additional, Juettemann, Thomas, additional, Keenan, Stephen, additional, Laird, Matthew R., additional, Lavidas, Ilias, additional, Maurel, Thomas, additional, McLaren, William, additional, Moore, Benjamin, additional, Murphy, Daniel N., additional, Nag, Rishi, additional, Newman, Victoria, additional, Nuhn, Michael, additional, Ong, Chuang Kee, additional, Parker, Anne, additional, Patricio, Mateus, additional, Riat, Harpreet Singh, additional, Sheppard, Daniel, additional, Sparrow, Helen, additional, Taylor, Kieron, additional, Thormann, Anja, additional, Vullo, Alessandro, additional, Walts, Brandon, additional, Wilder, Steven P., additional, Zadissa, Amonida, additional, Kostadima, Myrto, additional, Martin, Fergal J., additional, Muffato, Matthieu, additional, Perry, Emily, additional, Ruffier, Magali, additional, Staines, Daniel M., additional, Trevanion, Stephen J., additional, Cunningham, Fiona, additional, Yates, Andrew, additional, Zerbino, Daniel R., additional, and Flicek, Paul, additional
Published: 2016
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48. Erratum: Corrigendum: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

Author: Braasch, Ingo, primary, Gehrke, Andrew R, additional, Smith, Jeramiah J, additional, Kawasaki, Kazuhiko, additional, Manousaki, Tereza, additional, Pasquier, Jeremy, additional, Amores, Angel, additional, Desvignes, Thomas, additional, Batzel, Peter, additional, Catchen, Julian, additional, Berlin, Aaron M, additional, Campbell, Michael S, additional, Barrell, Daniel, additional, Martin, Kyle J, additional, Mulley, John F, additional, Ravi, Vydianathan, additional, Lee, Alison P, additional, Nakamura, Tetsuya, additional, Chalopin, Domitille, additional, Fan, Shaohua, additional, Wcisel, Dustin, additional, Cañestro, Cristian, additional, Sydes, Jason, additional, Beaudry, Felix E G, additional, Sun, Yi, additional, Hertel, Jana, additional, Beam, Michael J, additional, Fasold, Mario, additional, Ishiyama, Mikio, additional, Johnson, Jeremy, additional, Kehr, Steffi, additional, Lara, Marcia, additional, Letaw, John H, additional, Litman, Gary W, additional, Litman, Ronda T, additional, Mikami, Masato, additional, Ota, Tatsuya, additional, Saha, Nil Ratan, additional, Williams, Louise, additional, Stadler, Peter F, additional, Wang, Han, additional, Taylor, John S, additional, Fontenot, Quenton, additional, Ferrara, Allyse, additional, Searle, Stephen M J, additional, Aken, Bronwen, additional, Yandell, Mark, additional, Schneider, Igor, additional, Yoder, Jeffrey A, additional, Volff, Jean-Nicolas, additional, Meyer, Axel, additional, Amemiya, Chris T, additional, Venkatesh, Byrappa, additional, Holland, Peter W H, additional, Guiguen, Yann, additional, Bobe, Julien, additional, Shubin, Neil H, additional, Di Palma, Federica, additional, Alfo¨ldi, Jessica, additional, Lindblad-Toh, Kerstin, additional, and Postlethwait, John H, additional
Published: 2016
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49. Divergence in gene expression within and between two closely related flycatcher species

Author: Uebbing, Severin, primary, Künstner, Axel, additional, Mäkinen, Hannu, additional, Backström, Niclas, additional, Bolivar, Paulina, additional, Burri, Reto, additional, Dutoit, Ludovic, additional, Mugal, Carina F., additional, Nater, Alexander, additional, Aken, Bronwen, additional, Flicek, Paul, additional, Martin, Fergal J., additional, Searle, Stephen M. J., additional, and Ellegren, Hans, additional
Published: 2016
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50. The Ensembl gene annotation system

Author: Aken, Bronwen L., primary, Ayling, Sarah, additional, Barrell, Daniel, additional, Clarke, Laura, additional, Curwen, Valery, additional, Fairley, Susan, additional, Fernandez Banet, Julio, additional, Billis, Konstantinos, additional, García Girón, Carlos, additional, Hourlier, Thibaut, additional, Howe, Kevin, additional, Kähäri, Andreas, additional, Kokocinski, Felix, additional, Martin, Fergal J., additional, Murphy, Daniel N., additional, Nag, Rishi, additional, Ruffier, Magali, additional, Schuster, Michael, additional, Tang, Y. Amy, additional, Vogel, Jan-Hinnerk, additional, White, Simon, additional, Zadissa, Amonida, additional, Flicek, Paul, additional, and Searle, Stephen M. J., additional
Published: 2016
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