2,717 results on '"Akdis, Cezmi"'
Search Results
2. IL-37 protects against house dust mite-induced airway inflammation and airway epithelial barrier dysfunction via inhibiting store-operated calcium entry
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Wang, Changchang, Zhong, Jian, Hu, Jiaqian, Cao, Can, Qi, Shiquan, Ma, Ruxue, Fu, Wei, Zhang, Xiaolian, Akdis, Cezmi A., and Gao, Yadong
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- 2024
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3. Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort
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Schmid-Grendelmeier, Peter, Lauener, Roger, Bieber, Thomas, Brüggen, Marie-Charlotte, Renner, Ellen, Traidl-Hoffmann, Claudia, Akdis, Cezmi, Fieten, Karin B., Maya-Manzano, José M., Rückert, Beate, Candeias, Joana, Pusch, Gudrun, Buters, Jeroen, and Akdis, Cezmi A.
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- 2023
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4. Type 2 chronic inflammatory diseases: targets, therapies and unmet needs
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Kolkhir, Pavel, Akdis, Cezmi A., Akdis, Mübeccel, Bachert, Claus, Bieber, Thomas, Canonica, Giorgio Walter, Guttman-Yassky, Emma, Metz, Martin, Mullol, Joaquim, Palomares, Oscar, Renz, Harald, Ständer, Sonja, Zuberbier, Torsten, and Maurer, Marcus
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- 2023
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5. Author Correction: Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19
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Radzikowska, Urszula, Eljaszewicz, Andrzej, Tan, Ge, Stocker, Nino, Heider, Anja, Westermann, Patrick, Steiner, Silvio, Dreher, Anita, Wawrzyniak, Paulina, Rückert, Beate, Rodriguez-Coira, Juan, Zhakparov, Damir, Huang, Mengting, Jakiela, Bogdan, Sanak, Marek, Moniuszko, Marcin, O’Mahony, Liam, Jutel, Marek, Kebadze, Tatiana, Jackson, David J., Edwards, Michael R., Thiel, Volker, Johnston, Sebastian L., Akdis, Cezmi A., and Sokolowska, Milena
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- 2023
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6. Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19
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Radzikowska, Urszula, Eljaszewicz, Andrzej, Tan, Ge, Stocker, Nino, Heider, Anja, Westermann, Patrick, Steiner, Silvio, Dreher, Anita, Wawrzyniak, Paulina, Rückert, Beate, Rodriguez-Coira, Juan, Zhakparov, Damir, Huang, Mengting, Jakiela, Bogdan, Sanak, Marek, Moniuszko, Marcin, O’Mahony, Liam, Jutel, Marek, Kebadze, Tatiana, Jackson, David J., Edwards, Michael R., Thiel, Volker, Johnston, Sebastian L., Akdis, Cezmi A., and Sokolowska, Milena
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- 2023
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7. Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID‐19 patients
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Mitamura, Yasutaka, Schulz, Daniel, Oro, Saskia, Li, Nick, Kolm, Isabel, Lang, Claudia, Ziadlou, Reihane, Tan, Ge, Bodenmiller, Bernd, Steiger, Peter, Marzano, Angelo, Prost, Nicolas, Caudin, Olivier, Levesque, Mitchell, Stoffel, Corinne, Schmid‐Grendelmeier, Peter, Maverakis, Emanual, Akdis, Cezmi A, and Brüggen, Marie‐Charlotte
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Biomedical and Clinical Sciences ,Clinical Sciences ,Biotechnology ,Inflammatory and immune system ,Good Health and Well Being ,CD8-Positive T-Lymphocytes ,COVID-19 ,Exanthema ,Humans ,Pharmaceutical Preparations ,Proteomics ,SARS-CoV-2 ,coronavirus ,drug-induced maculopapular exanthema ,Immunology ,Allergy - Abstract
BackgroundCoronavirus disease-2019 (COVID-19) has been associated with cutaneous findings, some being the result of drug hypersensitivity reactions such as maculopapular drug rashes (MDR). The aim of this study was to investigate whether COVID-19 may impact the development of the MDR.MethodsBlood and skin samples from COVID-19 patients (based on a positive nasopharyngeal PCR) suffering from MDR (COVID-MDR), healthy controls, non-COVID-19-related patients with drug rash with eosinophilia and systemic symptoms (DRESS), and MDR were analyzed. We utilized imaging mass cytometry (IMC) to characterize the cellular infiltrate in skin biopsies. Furthermore, RNA sequencing transcriptome of skin biopsy samples and high-throughput multiplexed proteomic profiling of serum were performed.ResultsIMC revealed by clustering analyses a more prominent, phenotypically shifted cytotoxic CD8+ T cell population and highly activated monocyte/macrophage (Mo/Mac) clusters in COVID-MDR. The RNA sequencing transcriptome demonstrated a more robust cytotoxic response in COVID-MDR skin. However, severe acute respiratory syndrome coronavirus 2 was not detected in skin biopsies at the time point of MDR diagnosis. Serum proteomic profiling of COVID-MDR patients revealed upregulation of various inflammatory mediators (IL-4, IL-5, IL-6, TNF, and IFN-γ), eosinophil and Mo/Mac -attracting chemokines (MCP-2, MCP-3, MCP-4 and CCL11). Proteomics analyses demonstrated a massive systemic cytokine storm in COVID-MDR compared with the relatively milder cytokine storm observed in DRESS, while MDR did not exhibit such features.ConclusionA systemic cytokine storm may promote activation of Mo/Mac and cytotoxic CD8+ T cells in severe COVID-19 patients, which in turn may impact the development of MDR.
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- 2022
8. Assessing Different Feature Selection Methods Applied to a Bulk RNA Sequencing Dataset with Regard to Biomedical Relevance
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Zhakparov, Damir, Moriarty, Kathleen, Lunjani, Nonhlanhla, Schmid, Marco, Hlela, Carol, Levin, Michael, Mankahla, Avumile, Consortium, SOS-ALL, Akdis, Cezmi, O’Mahony, Liam, Baerenfaller, Katja, Roqueiro, Damian, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Koprinska, Irena, editor, Mignone, Paolo, editor, Guidotti, Riccardo, editor, Jaroszewicz, Szymon, editor, Fröning, Holger, editor, Gullo, Francesco, editor, Ferreira, Pedro M., editor, Roqueiro, Damian, editor, Ceddia, Gaia, editor, Nowaczyk, Slawomir, editor, Gama, João, editor, Ribeiro, Rita, editor, Gavaldà, Ricard, editor, Masciari, Elio, editor, Ras, Zbigniew, editor, Ritacco, Ettore, editor, Naretto, Francesca, editor, Theissler, Andreas, editor, Biecek, Przemyslaw, editor, Verbeke, Wouter, editor, Schiele, Gregor, editor, Pernkopf, Franz, editor, Blott, Michaela, editor, Bordino, Ilaria, editor, Danesi, Ivan Luciano, editor, Ponti, Giovanni, editor, Severini, Lorenzo, editor, Appice, Annalisa, editor, Andresini, Giuseppina, editor, Medeiros, Ibéria, editor, Graça, Guilherme, editor, Cooper, Lee, editor, Ghazaleh, Naghmeh, editor, Richiardi, Jonas, editor, Saldana, Diego, editor, Sechidis, Konstantinos, editor, Canakoglu, Arif, editor, Pido, Sara, editor, Pinoli, Pietro, editor, Bifet, Albert, editor, and Pashami, Sepideh, editor
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- 2023
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9. How does global warming contribute to disorders originating from an impaired epithelial barrier?
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Ozdemir, Cevdet, Kucuksezer, Umut Can, Ogulur, Ismail, Pat, Yagiz, Yazici, Duygu, Agache, Ioana, Jutel, Marek, Nadeau, Kari C., Akdis, Mübeccel, and Akdis, Cezmi A.
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- 2023
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10. The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
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Yazici, Duygu, Ogulur, Ismail, Pat, Yagiz, Babayev, Huseyn, Barletta, Elena, Ardicli, Sena, Bel imam, Manal, Huang, Mengting, Koch, Jana, Li, Manru, Maurer, Debbie, Radzikowska, Urszula, Satitsuksanoa, Pattraporn, Schneider, Stephan R., Sun, Na, Traidl, Stephan, Wallimann, Alexandra, Wawrocki, Sebastian, Zhakparov, Damir, Fehr, Danielle, Ziadlou, Reihane, Mitamura, Yasutaka, Brüggen, Marie-Charlotte, van de Veen, Willem, Sokolowska, Milena, Baerenfaller, Katja, Nadeau, Kari, Akdis, Mubeccel, and Akdis, Cezmi A.
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- 2023
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11. Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution
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Kim, Juyong Brian, Prunicki, Mary, Haddad, Francois, Dant, Christopher, Sampath, Vanitha, Patel, Rushali, Smith, Eric, Akdis, Cezmi, Balmes, John, Snyder, Michael P, Wu, Joseph C, and Nadeau, Kari C
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Aging ,Climate-Related Exposures and Conditions ,Prevention ,Cardiovascular ,Heart Disease ,Aetiology ,2.3 Psychological ,social and economic factors ,2.2 Factors relating to the physical environment ,Good Health and Well Being ,Sustainable Cities and Communities ,Adolescent ,Adolescent Development ,Adult ,Age Factors ,Aged ,Aged ,80 and over ,Air Pollutants ,Air Pollution ,Cardiovascular Diseases ,Child ,Child Development ,Child ,Preschool ,Comorbidity ,Environmental Exposure ,Female ,Global Health ,Humans ,Infant ,Infant ,Newborn ,Male ,Middle Aged ,Risk Assessment ,Risk Factors ,Time Factors ,Young Adult ,air pollutants ,environmental ,cardiovascular abnormalities ,cardiovascular disease ,epithelial barrier ,air pollutants ,environmental ,Cardiorespiratory Medicine and Haematology - Abstract
The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which-3.3 million-are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. Especially vulnerable are the elderly, patients with pre-existing CVD, and children. The cumulative lifetime burden in children is particularly of concern because their rapidly developing cardiopulmonary systems are more susceptible to damage and they spend more time outdoors and therefore inhale more pollutants. World Health Organization estimates that 93% of the world's children aged
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- 2020
12. Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation
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Akkoc, Tolga, O’Mahony, Liam, Ferstl, Ruth, Akdis, Cezmi, Akkoc, Tunc, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Turksen, Kursad, editor
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- 2022
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13. Sinonasal Epithelium Sino-nasal epithelium
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Soyka, Michael, Akdis, Cezmi A., Zhang, Luo, editor, and Bachert, Claus, editor
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- 2022
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14. Gut epithelial barrier damage caused by dishwasher detergents and rinse aids
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Ogulur, Ismail, Pat, Yagiz, Aydin, Tamer, Yazici, Duygu, Rückert, Beate, Peng, Yaqi, Kim, Juno, Radzikowska, Urszula, Westermann, Patrick, Sokolowska, Milena, Dhir, Raja, Akdis, Mubeccel, Nadeau, Kari, and Akdis, Cezmi A.
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- 2023
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15. Reporting Standards for Diagnostic Testing: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals
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Ost, David E., Feller-Kopman, David J., Gonzalez, Anne V., Grosu, Horiana B., Herth, Felix, Mazzone, Peter, Park, John E.S., Porcel, José M., Shojaee, Samira, Tsiligianni, Ioana, Vachani, Anil, Bernstein, Jonathan, Branson, Richard, Flume, Patrick A., Akdis, Cezmi A., Kolb, Martin, Portela, Esther Barreiro, and Smyth, Alan
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- 2023
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16. Disease Severity and Cytokine Expression in the Rhinovirus-Induced First Wheezing Episode
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Hurme, Pekka, primary, Kähkönen, Miisa, additional, Rückert, Beate, additional, Vahlberg, Tero, additional, Turunen, Riitta, additional, Vuorinen, Tytti, additional, Akdis, Mübeccel, additional, Akdis, Cezmi A., additional, and Jartti, Tuomas, additional
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- 2024
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17. Neue Nomenklatur allergischer Erkrankungen nach EAACI-Standard
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Jutel, Marek, primary, Ollert, Markus, additional, Vieths, Stefan, additional, Schwarze, Jürgen, additional, Agache, Ioana, additional, Akdis, Cezmi A., additional, and Klimek, Ludger, additional
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- 2024
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18. EAACI guidelines on environmental science for allergy and asthma: The impact of short‐term exposure to outdoor air pollutants on asthma‐related outcomes and recommendations for mitigation measures
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Agache, Ioana, primary, Annesi‐Maesano, Isabella, additional, Cecchi, Lorenzo, additional, Biagioni, Benedetta, additional, Chung, Kian Fan, additional, Clot, Bernard, additional, D'Amato, Gennaro, additional, Damialis, Athanasios, additional, del Giacco, Stefano, additional, Dominguez‐Ortega, Javier, additional, Galàn, Carmen, additional, Gilles, Stefanie, additional, Holgate, Stephen, additional, Jeebhay, Mohamed, additional, Kazadzis, Stelios, additional, Nadeau, Kari, additional, Papadopoulos, Nikolaos, additional, Quirce, Santiago, additional, Sastre, Joaquin, additional, Tummon, Fiona, additional, Traidl‐Hoffmann, Claudia, additional, Walusiak‐Skorupa, Jolanta, additional, Jutel, Marek, additional, and Akdis, Cezmi A., additional
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- 2024
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19. Epithelial barrier hypothesis and the development of allergic and autoimmune diseases
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Yazici, Duygu, Ogulur, Ismail, Kucukkase, Ozan, Li, Manru, Rinaldi, Arturo O., Pat, Yagiz, Wallimann, Alexandra, Wawrocki, Sebastian, Celebi Sozener, Zeynep, Buyuktiryaki, Betul, Sackesen, Cansin, Akdis, Mubeccel, Mitamura, Yasutaka, and Akdis, Cezmi A.
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- 2022
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20. Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming
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Angelina, Alba, Pérez-Diego, Mario, López-Abente, Jacobo, Rückert, Beate, Nombela, Ivan, Akdis, Mübeccel, Martín-Fontecha, Mar, Akdis, Cezmi, and Palomares, Oscar
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- 2022
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21. Hot topics in allergen immunotherapy, 2023: Current status and future perspective
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Zemelka‐Wiacek, Magdalena; https://orcid.org/0000-0001-7201-8638, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Akdis, Mübeccel; https://orcid.org/0000-0003-0554-9943, Casale, Thomas B; https://orcid.org/0000-0002-3149-7377, Dramburg, Stephanie; https://orcid.org/0000-0002-9303-3260, Jahnz‐Różyk, Karina; https://orcid.org/0000-0002-3505-1858, Kosowska, Anna; https://orcid.org/0000-0001-8991-0198, Matricardi, Paolo M; https://orcid.org/0000-0001-5485-0324, Pfaar, Oliver; https://orcid.org/0000-0003-4374-9639, Shamji, Mohamed H; https://orcid.org/0000-0003-3425-3463, Jutel, Marek; https://orcid.org/0000-0003-1555-9379, Zemelka‐Wiacek, Magdalena; https://orcid.org/0000-0001-7201-8638, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Akdis, Mübeccel; https://orcid.org/0000-0003-0554-9943, Casale, Thomas B; https://orcid.org/0000-0002-3149-7377, Dramburg, Stephanie; https://orcid.org/0000-0002-9303-3260, Jahnz‐Różyk, Karina; https://orcid.org/0000-0002-3505-1858, Kosowska, Anna; https://orcid.org/0000-0001-8991-0198, Matricardi, Paolo M; https://orcid.org/0000-0001-5485-0324, Pfaar, Oliver; https://orcid.org/0000-0003-4374-9639, Shamji, Mohamed H; https://orcid.org/0000-0003-3425-3463, and Jutel, Marek; https://orcid.org/0000-0003-1555-9379
- Abstract
The importance of allergen immunotherapy (AIT) is multifaceted, encompassing both clinical and quality‐of‐life improvements and cost‐effectiveness in the long term. Key mechanisms of allergen tolerance induced by AIT include changes in memory type allergen‐specific T‐ and B‐cell responses towards a regulatory phenotype with decreased Type 2 responses, suppression of allergen‐specific IgE and increased IgG$_{1}$ and IgG$_{4}$, decreased mast cell and eosinophil numbers in allergic tissues and increased activation thresholds. The potential of novel patient enrolment strategies for AIT is taking into account recent advances in biomarkers discoveries, molecular allergy diagnostics and mobile health applications contributing to a personalized approach enhancement that can increase AIT efficacy and compliance. Artificial intelligence can help manage and interpret complex and heterogeneous data, including big data from omics and non‐omics research, potentially predict disease subtypes, identify biomarkers and monitor patient responses to AIT. Novel AIT preparations, such as synthetic compounds, innovative carrier systems and adjuvants, are also of great promise. Advances in clinical trial models, including adaptive, complex and hybrid designs as well as real‐world evidence, allow more flexibility and cost reduction. The analyses of AIT cost‐effectiveness show a clear long‐term advantage compared to pharmacotherapy. Important research questions, such as defining clinical endpoints, biomarkers of patient selection and efficacy, mechanisms and the modulation of the placebo effect and alternatives to conventional field trials, including allergen exposure chamber studies are still to be elucidated. This review demonstrates that AIT is still in its growth phase and shows immense development prospects.
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- 2024
22. Rural and urban exposures shape early life immune development in South African children with atopic dermatitis and nonallergic children
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Lunjani, Nonhlanhla, Ambikan, Anoop T, Hlela, Carol, Levin, Michael; https://orcid.org/0000-0003-2439-7981, Mankahla, Avumile, Heldstab‐Kast, Jeannette I, Boonpiyathad, Tadech; https://orcid.org/0000-0001-8690-7647, Tan, Ge; https://orcid.org/0000-0003-0026-8739, Altunbulakli, Can; https://orcid.org/0000-0003-2264-7377, Gray, Clive, Nadeau, Kari C; https://orcid.org/0000-0002-2146-2955, Neogi, Ujjwal, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, O'Mahony, Liam; https://orcid.org/0000-0003-4705-3583, Lunjani, Nonhlanhla, Ambikan, Anoop T, Hlela, Carol, Levin, Michael; https://orcid.org/0000-0003-2439-7981, Mankahla, Avumile, Heldstab‐Kast, Jeannette I, Boonpiyathad, Tadech; https://orcid.org/0000-0001-8690-7647, Tan, Ge; https://orcid.org/0000-0003-0026-8739, Altunbulakli, Can; https://orcid.org/0000-0003-2264-7377, Gray, Clive, Nadeau, Kari C; https://orcid.org/0000-0002-2146-2955, Neogi, Ujjwal, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, and O'Mahony, Liam; https://orcid.org/0000-0003-4705-3583
- Abstract
Background Immunological traits and functions have been consistently associated with environmental exposures and are thought to shape allergic disease susceptibility and protection. In particular, specific exposures in early life may have more significant effects on the developing immune system, with potentially long‐term impacts. Methods We performed RNA‐Seq on peripheral blood mononuclear cells (PBMCs) from 150 children with atopic dermatitis and healthy nonallergic children in rural and urban settings from the same ethnolinguistic AmaXhosa background in South Africa. We measured environmental exposures using questionnaires. Results A distinct PBMC gene expression pattern was observed in those children with atopic dermatitis (132 differentially expressed genes [DEGs]). However, the predominant influences on the immune cell transcriptome were related to early life exposures including animals, time outdoors, and types of cooking and heating fuels. Sample clustering revealed two rural groups (Rural_1 and Rural_2) that separated from the urban group (3413 and 2647 DEGs, respectively). The most significantly regulated pathways in Rural_1 children were related to innate activation of the immune system (e.g., TLR and cytokine signaling), changes in lymphocyte polarization (e.g., TH17 cells), and immune cell metabolism (i.e., oxidative phosphorylation). The Rural_2 group displayed evidence for ongoing lymphocyte activation (e.g., T cell receptor signaling), with changes in immune cell survival and proliferation (e.g., mTOR signaling, insulin signaling). Conclusions This study highlights the importance of the exposome on immune development in early life and identifies potentially protective (e.g., animal) exposures and potentially detrimental (e.g., pollutant) exposures that impact key immunological pathways.
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- 2024
23. Addressing adverse synergies between chemical and biological pollutants at schools—The ‘SynAir-G’ hypothesis
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Papadopoulos, Nikolaos G; https://orcid.org/0000-0002-4448-3468, Akdis, Cezmi; https://orcid.org/0000-0001-8020-019X, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Damialis, Athanasios; https://orcid.org/0000-0003-2917-5667, Esposito, Giuseppina; https://orcid.org/0000-0003-2811-4678, Fergadiotou, Ioana; https://orcid.org/0000-0002-8940-2094, Goroncy, Christian, Guitton, Pierre, Gotua, Maia; https://orcid.org/0000-0003-2497-4128, Erotokritou, Kleanthis; https://orcid.org/0000-0002-7284-104X, Jartti, Tuomas; https://orcid.org/0000-0003-2748-5362, Murray, Clare; https://orcid.org/0000-0002-8961-8055, Nenes, Athanasios; https://orcid.org/0000-0003-3873-9970, Nikoletseas, Sotirios; https://orcid.org/0000-0003-3765-5636, Finotto, Susetta; https://orcid.org/0000-0001-7623-7977, Pandis, Spyros N; https://orcid.org/0000-0001-8085-9795, Ramiconi, Valeria, Simpson, Angela; https://orcid.org/0000-0003-2733-6666, Soudunsaari, Aki, Stårbröst, Anna, Staiano, Maria; https://orcid.org/0000-0003-0223-1825, Varriale, Antonio; https://orcid.org/0000-0003-0985-9877, Xepapadaki, Paraskevi; https://orcid.org/0000-0001-9204-1923, Zuberbier, Torsten; https://orcid.org/0000-0002-1466-8875, Annesi‐Maesano, Isabella; https://orcid.org/0000-0002-6340-9300, Papadopoulos, Nikolaos G; https://orcid.org/0000-0002-4448-3468, Akdis, Cezmi; https://orcid.org/0000-0001-8020-019X, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Damialis, Athanasios; https://orcid.org/0000-0003-2917-5667, Esposito, Giuseppina; https://orcid.org/0000-0003-2811-4678, Fergadiotou, Ioana; https://orcid.org/0000-0002-8940-2094, Goroncy, Christian, Guitton, Pierre, Gotua, Maia; https://orcid.org/0000-0003-2497-4128, Erotokritou, Kleanthis; https://orcid.org/0000-0002-7284-104X, Jartti, Tuomas; https://orcid.org/0000-0003-2748-5362, Murray, Clare; https://orcid.org/0000-0002-8961-8055, Nenes, Athanasios; https://orcid.org/0000-0003-3873-9970, Nikoletseas, Sotirios; https://orcid.org/0000-0003-3765-5636, Finotto, Susetta; https://orcid.org/0000-0001-7623-7977, Pandis, Spyros N; https://orcid.org/0000-0001-8085-9795, Ramiconi, Valeria, Simpson, Angela; https://orcid.org/0000-0003-2733-6666, Soudunsaari, Aki, Stårbröst, Anna, Staiano, Maria; https://orcid.org/0000-0003-0223-1825, Varriale, Antonio; https://orcid.org/0000-0003-0985-9877, Xepapadaki, Paraskevi; https://orcid.org/0000-0001-9204-1923, Zuberbier, Torsten; https://orcid.org/0000-0002-1466-8875, and Annesi‐Maesano, Isabella; https://orcid.org/0000-0002-6340-9300
- Abstract
While the number and types of indoor air pollutants is rising, much is suspected but little is known about the impact of their potentially synergistic interactions, upon human health. Gases, particulate matter, organic compounds but also allergens and viruses, fall within the ‘pollutant’ definition. Distinct populations, such as children and allergy and asthma sufferers are highly susceptible, while a low socioeconomic background is a further susceptibility factor; however, no specific guidance is available. We spend most of our time indoors; for children, the school environment is of paramount importance and potentially amenable to intervention. The interactions between some pollutant classes have been studied. However, a lot is missing with respect to understanding interactions between specific pollutants of different classes in terms of concentrations, timing and sequence, to improve targeting and upgrade standards. SynAir‐G is a European Commission‐funded project aiming to reveal and quantify synergistic interactions between different pollutants affecting health, from mechanisms to real life, focusing on the school setting. It will develop a comprehensive and responsive multipollutant monitoring system, advance environmentally friendly interventions, and disseminate the generated knowledge to relevant stakeholders in accessible and actionable formats. The aim of this article it to put forward the SynAir‐G hypothesis, and describe its background and objectives.
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- 2024
24. Electrical impedance spectroscopy detects skin barrier dysfunction in childhood atopic dermatitis
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Sasaki, Mari; https://orcid.org/0000-0003-1590-3838, Sundberg, Mathilda, Frei, Remo, Ferstl, Ruth, Heye, Kristina N, Willems, Erik P, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Lauener, Roger, Roduit, Caroline; https://orcid.org/0000-0002-5988-0570, Sasaki, Mari; https://orcid.org/0000-0003-1590-3838, Sundberg, Mathilda, Frei, Remo, Ferstl, Ruth, Heye, Kristina N, Willems, Erik P, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Lauener, Roger, and Roduit, Caroline; https://orcid.org/0000-0002-5988-0570
- Abstract
Background Skin barrier dysfunction is associated with the development of atopic dermatitis (AD), however methods to assess skin barrier function are limited. We investigated the use of electrical impedance spectroscopy (EIS) to detect skin barrier dysfunction in children with AD of the CARE (Childhood AlleRgy, nutrition, and Environment) cohort. Methods EIS measurements taken at multiple time points from 4 months to 3‐year‐old children, who developed AD (n = 66) and those who did not (n = 49) were investigated. Using only the EIS measurement and the AD status, we developed a machine learning algorithm that produces a score (EIS/AD score) which reflects the probability that a given measurement is from a child with active AD. We investigated the diagnostic ability of this score and its association with clinical characteristics and age. Results Based on the EIS/AD score, the EIS algorithm was able to clearly discriminate between healthy skin and clinically unaffected skin of children with active AD (area under the curve 0.92, 95% CI 0.85–0.99). It was also able to detect a difference between healthy skin and AD skin when the child did not have active AD. There was no clear association between the EIS/AD score and the severity of AD or sensitisation to the tested allergens. The performance of the algorithm was not affected by age. Conclusions This study shows that EIS can detect skin barrier dysfunction and differentiate skin of children with AD from healthy skin and suggests that EIS may have the ability to predict future AD development.
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- 2024
25. Recent advances in the epithelial barrier theory
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Pat, Yagiz; https://orcid.org/0000-0003-4268-4933, Yazici, Duygu; https://orcid.org/0000-0001-9094-6542, D'Avino, Paolo; https://orcid.org/0009-0005-6212-4265, Li, Manru; https://orcid.org/0000-0003-4870-6021, Ardicli, Sena; https://orcid.org/0000-0003-2758-5945, Ardicli, Ozge; https://orcid.org/0000-0001-6077-0478, Mitamura, Yasutaka; https://orcid.org/0000-0001-6389-9285, Akdis, Mübeccel; https://orcid.org/0000-0003-0554-9943, Dhir, Raja, Nadeau, Kari; https://orcid.org/0000-0002-2146-2955, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Ogulur, Ismail; https://orcid.org/0000-0001-8282-7762, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Pat, Yagiz; https://orcid.org/0000-0003-4268-4933, Yazici, Duygu; https://orcid.org/0000-0001-9094-6542, D'Avino, Paolo; https://orcid.org/0009-0005-6212-4265, Li, Manru; https://orcid.org/0000-0003-4870-6021, Ardicli, Sena; https://orcid.org/0000-0003-2758-5945, Ardicli, Ozge; https://orcid.org/0000-0001-6077-0478, Mitamura, Yasutaka; https://orcid.org/0000-0001-6389-9285, Akdis, Mübeccel; https://orcid.org/0000-0003-0554-9943, Dhir, Raja, Nadeau, Kari; https://orcid.org/0000-0002-2146-2955, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Ogulur, Ismail; https://orcid.org/0000-0001-8282-7762, and Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X
- Abstract
The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier. Global pollution and environmental toxic agent exposure have worsened over six decades because of uncontrolled growth, modernisation, and industrialisation, affecting human health. Introducing new chemicals without any reasonable control of their health effects through these years has led to documented adverse effects, especially on the skin and mucosal epithelial barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- and nano-plastics, diesel exhaust, cigarette smoke and ozone, have been shown to compromise the epithelial barrier integrity. This disruption is linked to the opening of the tight junction barriers, inflammation, cell death, oxidative stress and metabolic regulation. Consideration must be given to the interplay of toxic substances, underlying inflammatory diseases, and medications, especially in affected tissues. This review article discusses the detrimental effect of environmental barrier-damaging compounds on human health and involves cellular and molecular mechanisms.
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- 2024
26. Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin
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Rinaldi, Arturo O; https://orcid.org/0000-0001-8967-3866, Li, Manru, Barletta, Elena; https://orcid.org/0000-0002-8431-4140, D'Avino, Paolo, Yazici, Duygu; https://orcid.org/0000-0001-9094-6542, Pat, Yagiz; https://orcid.org/0000-0003-4268-4933, Ward, Siobhan, Burla, Daniel, Tan, Ge; https://orcid.org/0000-0003-0026-8739, Askary, Nima, Larsson, Rasmus, Bost, Jeremy, Babayev, Huseyn, Dhir, Raja, Gaudenzio, Nicolas, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Nadeau, Kari; https://orcid.org/0000-0002-2146-2955, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Mitamura, Yasutaka; https://orcid.org/0000-0001-6389-9285, Rinaldi, Arturo O; https://orcid.org/0000-0001-8967-3866, Li, Manru, Barletta, Elena; https://orcid.org/0000-0002-8431-4140, D'Avino, Paolo, Yazici, Duygu; https://orcid.org/0000-0001-9094-6542, Pat, Yagiz; https://orcid.org/0000-0003-4268-4933, Ward, Siobhan, Burla, Daniel, Tan, Ge; https://orcid.org/0000-0003-0026-8739, Askary, Nima, Larsson, Rasmus, Bost, Jeremy, Babayev, Huseyn, Dhir, Raja, Gaudenzio, Nicolas, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Nadeau, Kari; https://orcid.org/0000-0002-2146-2955, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, and Mitamura, Yasutaka; https://orcid.org/0000-0001-6389-9285
- Abstract
BackgroundEpithelial barrier impairment is associated with many skin and mucosal inflammatory disorders. Laundry detergents have been demonstrated to affect epithelial barrier function in vitro using air–liquid interface cultures of human epithelial cells.MethodsBack skin of C57BL/6 mice was treated with two household laundry detergents at several dilutions. Barrier function was assessed by electric impedance spectroscopy (EIS) and transepidermal water loss (TEWL) measurements after the 4 h of treatments with detergents. RNA sequencing (RNA‐seq) and targeted multiplex proteomics analyses in skin biopsy samples were performed. The 6‐h treatment effect of laundry detergent and sodium dodecyl sulfate (SDS) was investigated on ex vivo human skin.ResultsDetergent‐treated skin showed a significant EIS reduction and TEWL increase compared to untreated skin, with a relatively higher sensitivity and dose–response in EIS. The RNA‐seq showed the reduction of the expression of several genes essential for skin barrier integrity, such as tight junctions and adherens junction proteins. In contrast, keratinization, lipid metabolic processes, and epidermal cell differentiation were upregulated. Proteomics analysis showed that the detergents treatment generally downregulated cell adhesion‐related proteins, such as epithelial cell adhesion molecule and contactin‐1, and upregulated proinflammatory proteins, such as interleukin 6 and interleukin 1 beta. Both detergent and SDS led to a significant decrease in EIS values in the ex vivo human skin model.ConclusionThe present study demonstrated that laundry detergents and its main component, SDS impaired the epidermal barrier in vivo and ex vivo human skin. Daily detergent exposure may cause skin barrier disruption and may contribute to the development of atopic diseases.
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- 2024
27. Regulation of immune response genes in the skin of allergic and clinically tolerant individuals exposed to p-phenylenediamine
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Meisser, Sanne S., Mitamura, Yasutaka, Altunbulakli, Can, Bandier, Josefine, Opstrup, Morten S., Gadsbøll, Anne Sofie Ø., Li, Manru, Tan, Ge, Akdis, Mubeccel, Akdis, Cezmi A., Geisler, Carsten, Johansen, Jeanne D., Bonefeld, Charlotte M., Meisser, Sanne S., Mitamura, Yasutaka, Altunbulakli, Can, Bandier, Josefine, Opstrup, Morten S., Gadsbøll, Anne Sofie Ø., Li, Manru, Tan, Ge, Akdis, Mubeccel, Akdis, Cezmi A., Geisler, Carsten, Johansen, Jeanne D., and Bonefeld, Charlotte M.
- Abstract
Background: p-Phenylenediamine (PPD) is a potent contact allergen found in many hair colour products. However, not all individuals develop allergic contact dermatitis (ACD) although they are regularly exposed to PPD. It is unclear whether these asymptomatic individuals are true non-responders to PPD or whether they mount a response to PPD without showing any symptoms. Methods: Skin biopsies were collected from 11 asymptomatic hairdressers regularly exposed to PPD and from 10 individuals with known ACD on day 4 after patch testing with 1% PPD in petrolatum and petrolatum exclusively as control. RNA sequencing and confocal microscopy were performed. Results: T cell activation, inflammation and apoptosis pathways were up-regulated by PPD in both asymptomatic and allergic individuals. Compared to asymptomatic individuals with a negative patch test, individuals with a strong reaction to PPD strongly up-regulated both pro- and anti-inflammatory cytokines genes. Interestingly, PPD treatment induced significant up-regulation of several genes for chemokines, classical type 2 dendritic cell markers and regulatory T cell markers in both asymptomatic and allergic individuals. In addition, apoptosis signalling pathway was activated in both non-responders and allergic individuals. Conclusion: This study demonstrates that there are no true non-responders to PPD but that the immune response elicited by PPD differs between individuals and can lead to either tolerance, subclinical inflammation or allergy.
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- 2024
28. Human Ascaris infection is associated with higher frequencies of IL-10 producing B cells.
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Zakzuk, Josefina, Lopez, Juan F., Akdis, Cezmi, Caraballo, Luis, Akdis M., Mübeccel, and van de Veen, Willem
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REGULATORY B cells ,ANTIBODY formation ,B cells ,CELL populations ,ASCARIS lumbricoides - Abstract
Introduction: Ascaris lumbricoides has dual effects on the immune system of infected hosts. The IgE response to this parasite has been thoroughly studied, but little is known about cellular responses induced by infection. This study aims to explore the interplay between A. lumbricoides infection and B cell responses, especially B regulatory cells. Methods: Participants from Santa Catalina, Bolívar, Colombia, a helminth-endemic town, were screened for soil-transmitted helminthiasis (STH) using stool examinations. Eighteen A. lumbricoides-infected and 11 non-infected subjects were selected. Blood samples were analyzed for Breg cells and related cytokines, and immunoglobulins specific to the A. lumbricoides excretory/secretory product, ABA-1. Results: Infected subjects exhibited higher frequencies of Breg cells, especially those with a higher A. lumbricoides egg burden. Higher frequencies of different Breg subsets were observed in infected individuals, with CD25
+ CD71+ CD73- B cells being notably increased in strongly infected individuals. Additionally, A. lumbricoides infection was associated with reduced levels of circulating ABA-1-specific IgG1 and IgE. IL-10+ B cell frequencies correlated inversely with ABA-1-specific IgE. Conclusions: A. lumbricoides infection has a significant impact on the immune response, particularly on Breg cell populations and antibody responses. Our findings suggest that A. lumbricoides infection mediates a dose-dependent immunosuppressive response characterized by an increase in Breg cells and concomitant suppression of ABA-1-specific humoral responses. Author summary: Ascaris lumbricoides, a common parasitic worm, may modulate the immune system in different ways. While much is known about the IgE antibody response to this parasite, the cellular immune responses remain less understood. Our research question in this study was how A. lumbricoides infection influences B cell responses, with a focus on regulatory B cells (Bregs). We conducted our research in a rural town in the North Coast of Colombia, an area where soil-transmitted helminth infections are prevalent. We compared blood samples from 18 individuals infected with A. lumbricoides and 11 non-infected individuals to analyze Breg cells, related cytokines, and specific antibodies against the parasite's excretory/secretory product, ABA-1. We observed that individuals infected with A. lumbricoides have higher frequencies of Breg cells, especially those with a more intense infection (higher counts of parasite eggs in feces). In particular, certain subsets of Breg cells were significantly elevated in those with higher parasite loads. Interestingly, infection was also linked to reduced levels of antibodies specific to ABA-1. Notably, the frequency of IL-10+ Breg cells was inversely related to the levels of ABA-1-specific IgE. In conclusion, A. lumbricoides infection may induce immunosuppressive responses, marked by an increase in regulatory B cells and a decrease in specific antibody responses. These findings highlight the intricate ways in which this parasite modulates the immune system, which could have implications for understanding immune regulation in parasitic infections. [ABSTRACT FROM AUTHOR]- Published
- 2024
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29. Ultra‐processed foods, allergy outcomes and underlying mechanisms in children: An EAACI task force report.
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Berni Canani, Roberto, Carucci, Laura, Coppola, Serena, D'Auria, Enza, O'Mahony, Liam, Roth‐Walter, Franziska, Vassilopolou, Emilia, Agostoni, Carlo, Agache, Ioana, Akdis, Cezmi, De Giovanni Di Santa Severina, Fiorenza, Faketea, Gavriela, Greenhawt, Matt, Hoffman, Karin, Hufnagl, Karin, Meyer, Rosan, Milani, Gregorio Paolo, Nowak‐Wegrzyn, Anna, Nwaru, Bright, and Padua, Ines
- Abstract
Background: Consumption of ultra‐processed foods [UPFs] may be associated with negative health outcomes. Limited data exist regarding the potential role of UPFs in the occurrence of allergic diseases. The underlying mechanisms underpinning any such associations are also poorly elucidated. Methods: We performed a systematic review and narrative evidence synthesis of the available literature to assess associations between UPF consumption and pediatric allergy outcomes (n = 26 papers), including data on the association seen with the gut microbiome (n = 16 papers) or immune system (n = 3 papers) structure and function following PRISMA guidelines. Results: Dietary exposure to fructose, carbonated soft drinks, and sugar intake was associated with an increased risk of asthma, allergic rhinitis, and food allergies in children. Commercial baby food intake was associated with childhood food allergy. Childhood intake of fructose, fruit juices, sugar‐sweetened beverages, high carbohydrate UPFs, monosodium glutamate, UPFs, and advanced glycated end‐products (AGEs) was associated with the occurrence of allergic diseases. Exposure to UPFs and common ingredients in UPFs seem to be associated with increased occurrence of allergic diseases such as asthma, wheezing, food allergies, atopic dermatitis, and allergic rhinitis, in many, but not all studies. Conclusion: More preclinical and clinical studies are required to better define the link between UPF consumption and the risk of allergies and asthma. These observational studies ideally require supporting data with clearly defined UPF consumption, validated dietary measures, and mechanistic assessments to definitively link UPFs with the risk of allergies and asthma. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Single cell multi-omic analysis identifies key genes differentially expressed in innate lymphoid cells from COVID-19 patients.
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Kaushik, Abhinav, Chang, Iris, Xiaorui Han, Ziyuan He, Komlosi, Zsolt I., Xuhuai Ji, Shu Cao, Akdis, Cezmi A., Boyd, Scott, Pulendran, Bali, Maecker, Holden T., Davis, Mark M., Chinthrajah, R. Sharon, DeKruyff, Rosemarie H., and Nadeau, Kari C.
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INNATE lymphoid cells ,COVID-19 ,COVID-19 pandemic ,CELL analysis ,GENE regulatory networks - Abstract
Introduction: Innate lymphoid cells (ILCs) are enriched at mucosal surfaces where they respond rapidly to environmental stimuli and contribute to both tissue inflammation and healing. Methods: To gain insight into the role of ILCs in the pathology and recovery from COVID-19 infection, we employed a multi-omics approach consisting of Abseq and targeted mRNA sequencing to respectively probe the surface marker expression, transcriptional profile and heterogeneity of ILCs in peripheral blood of patients with COVID-19 compared with healthy controls. Results: We found that the frequency of ILC1 and ILC2 cells was significantly increased in COVID-19 patients. Moreover, all ILC subsets displayed a significantly higher frequency of CD69-expressing cells, indicating a heightened state of activation. ILC2s from COVID-19 patients had the highest number of significantly differentially expressed (DE) genes. The most notable genes DE in COVID-19 vs healthy participants included a) genes associated with responses to virus infections and b) genes that support ILC self-proliferation, activation and homeostasis. In addition, differential gene regulatory network analysis revealed ILC-specific regulons and their interactions driving the differential gene expression in each ILC. Discussion: Overall, this study provides mechanistic insights into the characteristics of ILC subsets activated during COVID-19 infection. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Indoor and outdoor pollutants—No safe amount of air to breathe in.
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Agache, Ioana, Jutel, Marek, and Akdis, Cezmi A.
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WHEEZE ,POLLUTANTS ,EMERGENCY room visits - Abstract
The article discusses the interconnectedness of planetary health and human health, specifically focusing on the impact of indoor and outdoor pollutants on asthma-related outcomes. The European Academy of Allergy and Clinical Immunology (EAACI) conducted systematic reviews to evaluate the effects of pollution on patients with asthma and provide recommendations for prevention and patient care. The article highlights the risks associated with exposure to outdoor air pollutants, such as particulate matter and traffic-related pollutants, as well as indoor pollutants like volatile organic compounds, cleaning agents, and pesticides. The guidelines emphasize the importance of reducing exposure to pollutants and implementing personalized interventions for asthma management. Additionally, the article addresses the impact of tobacco smoke on asthma outcomes and the need for further research to establish causal relationships between pollutants and adverse asthma-related outcomes. The guidelines aim to improve asthma care and advocate for multilevel, multi-sectoral actions to reduce emissions, improve air quality, and prioritize underserved populations. [Extracted from the article]
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- 2024
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32. Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
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Akdis, Cezmi A.
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- 2021
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33. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
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Wise, Sarah K, Lin, Sandra Y, Toskala, Elina, Orlandi, Richard R, Akdis, Cezmi A, Alt, Jeremiah A, Azar, Antoine, Baroody, Fuad M, Bachert, Claus, Canonica, G Walter, Chacko, Thomas, Cingi, Cemal, Ciprandi, Giorgio, Corey, Jacquelynne, Cox, Linda S, Creticos, Peter Socrates, Custovic, Adnan, Damask, Cecelia, DeConde, Adam, DelGaudio, John M, Ebert, Charles S, Eloy, Jean Anderson, Flanagan, Carrie E, Fokkens, Wytske J, Franzese, Christine, Gosepath, Jan, Halderman, Ashleigh, Hamilton, Robert G, Hoffman, Hans Jürgen, Hohlfeld, Jens M, Houser, Steven M, Hwang, Peter H, Incorvaia, Cristoforo, Jarvis, Deborah, Khalid, Ayesha N, Kilpeläinen, Maritta, Kingdom, Todd T, Krouse, Helene, Larenas-Linnemann, Desiree, Laury, Adrienne M, Lee, Stella E, Levy, Joshua M, Luong, Amber U, Marple, Bradley F, McCoul, Edward D, McMains, K Christopher, Melén, Erik, Mims, James W, Moscato, Gianna, Mullol, Joaquim, Nelson, Harold S, Patadia, Monica, Pawankar, Ruby, Pfaar, Oliver, Platt, Michael P, Reisacher, William, Rondón, Carmen, Rudmik, Luke, Ryan, Matthew, Sastre, Joaquin, Schlosser, Rodney J, Settipane, Russell A, Sharma, Hemant P, Sheikh, Aziz, Smith, Timothy L, Tantilipikorn, Pongsakorn, Tversky, Jody R, Veling, Maria C, Wang, De Yun, Westman, Marit, Wickman, Magnus, and Zacharek, Mark
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Allergic Rhinitis (Hay Fever) ,Adrenal Cortex Hormones ,Allergens ,Biological Products ,Complementary Therapies ,Cytokines ,Diagnosis ,Differential ,Drug Therapy ,Combination ,Endoscopy ,Environmental Exposure ,Epidemiologic Methods ,Histamine Antagonists ,Humans ,Immunoglobulin E ,Microbiota ,Nasal Decongestants ,Occupational Diseases ,Physical Examination ,Probiotics ,Quality of Life ,Respiratory Mucosa ,Rhinitis ,Allergic ,Risk Factors ,Saline Solution ,Skin Tests ,Socioeconomic Factors ,allergen extract ,allergy ,allergen immunotherapy ,allergic rhinitis ,antihistamine ,asthma ,atopic dermatitis ,avoidance ,biologic ,cockroach ,conjunctivitis ,consensus ,corticosteroid ,cough ,cromolyn ,decongestant ,eosinophilic esophagitis ,environment ,epicutaneous immunotherapy ,epidemiology ,evidence-based medicine ,food allergy ,genetics ,house dust mite ,IgE ,immunoglobulin E ,immunotherapy ,inhalant allergy ,leukotriene ,microbiome ,occupational rhinitis ,omalizumab ,pathophysiology ,perennial ,pet dander ,pollen ,probiotic ,quality of life ,rhinitis ,rhinosinusitis ,risk factor ,saline ,seasonal ,sensitization ,sinusitis ,sleep ,socioeconomic ,specific IgE ,subcutaneous immunotherapy ,sublingual immunotherapy ,systematic review ,total IgE ,transcutaneous immunotherapy ,validated survey ,Immunology - Abstract
BackgroundCritical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).MethodsUsing previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus.ResultsThe ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR.ConclusionThis critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.
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- 2018
34. Introduction to Mechanisms of Allergic Diseases
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Sahiner, Umit, primary, Akdis, Mübeccel, additional, and Akdis, Cezmi A., additional
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- 2022
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35. Sinonasal Epithelium
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Soyka, Michael, primary and Akdis, Cezmi A., additional
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- 2022
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36. Contributors
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Akdis, Cezmi A., primary, Akdis, Mübeccel, additional, Baroody, Fuad M., additional, Boguniewicz, Mark, additional, Brown, Simon G.A., additional, Burks, A. Wesley, additional, Chiriac, Anca-Mirela, additional, Corren, Jonathan, additional, Custovic, Adnan, additional, Demoly, Pascal, additional, Fonacier, Luz, additional, Golden, David B.K., additional, Grattan, Clive E.H., additional, Hausmann, Oliver V., additional, Khurana Hershey, Gurjit K., additional, Holgate, Stephen T., additional, Joerg, Lukas, additional, Lemière, Catherine, additional, Leung, Donald Y.M., additional, Mersha, Tesfaye B., additional, Nowak-Węgrzyn, Anna, additional, O'Hehir, Robyn E., additional, Robinson, Clive, additional, Sahiner, Umit, additional, Saini, Sarbjit S., additional, Sampson, Hugh A., additional, Sheikh, Aziz, additional, Sherenian, Michael G., additional, Smith, Helen E., additional, Stewart, Geoffrey A., additional, Suojalehto, Hille, additional, and Turner, Paul J., additional
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- 2022
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37. IL-33 receptor expression on myeloid and plasmacytoid dendritic cells after allergen challenge in patients with allergic rhinitis
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Peng, Ya-Qi, Chen, De-Hua, Xu, Zhi-Bin, Fang, Shu-Bing, He, Bi-Xin, Liu, Xiao-Qing, Akdis, Cezmi A., and Fu, Qing-Ling
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- 2021
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38. Environmental exposures drive the development of allergic diseases
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Zhang, Luo, primary and Akdis, Cezmi A., additional
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- 2024
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39. Navigating the Evolving Landscape of Atopic Dermatitis: Challenges and Future Opportunities: the 4 th Davos Declaration
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Traidl-Hoffmann, Claudia, primary, Afghani, Jamie, additional, Akdis, Cezmi, additional, Akdis, Mubeccel, additional, Handan, Aydin, additional, Baerenfaller, Katja, additional, Behrendt, Heidrun, additional, Bieber, Thomas, additional, Bigliardi, Paul L., additional, Bigliardi-Qi, Mei, additional, Bonefeld, Charlotte, additional, Bösch, Stefanie, additional, Brüggen, Marie-Charlotte, additional, Diemert, Sebastian, additional, Duchna, Hans-Werner, additional, Fähndrich, Martina, additional, Fehr, Danielle, additional, Fellmann, Marc, additional, Frei, Remo, additional, Garvey, Lene, additional, Gharbo, Raschid, additional, Gökkaya, Mehmet, additional, Grando, Karin, additional, Guillet, Carole, additional, Güler, Erman, additional, Gutermuth, Jan, additional, Herrmann, Nadine, additional, Hijnen, DirkJan, additional, Hülpüsch, Claudia, additional, Irvine, Alan, additional, Jensen-Jarolim, Erika, additional, Kong, Heidi H, additional, Koren, Hillel, additional, Lang, Claudia, additional, Lauener, Roger, additional, Maintz, Laura, additional, Mantel, Pierre-Yves, additional, maverakis, Emanual, additional, Moehrenschlager, Matthias, additional, Müller, Svenja, additional, Nadeau, Kari, additional, Neumann, Avidan U., additional, O'Mahony, Liam, additional, Rabenja, Fahafahantsoa Rapelanoro, additional, Renz, Harald, additional, Rhyner, Claudio, additional, Rietschel, Ernst, additional, Ring, Johannes, additional, Roduit, Caroline, additional, Sasaki, Mari, additional, Schenk, Mirjam, additional, Schroder, Jens, additional, Simon, Dagmar, additional, Simon, Hans-Uwe, additional, Sokolowska, Milena, additional, stander, sonja, additional, Steinhoff, Martin, additional, Piccirillo, Doris Straub, additional, Taïeb, Alain, additional, Takaoka, Roberto, additional, Tapparo, Martin, additional, Teixeira, Henrique, additional, Thyssen, Jacob, additional, Traidl, Stephan, additional, Uhlmann, Miriam, additional, Veen, Willem van de, additional, Hage, Marianne van, additional, Virchow, Christian, additional, Wollenberg, Andreas, additional, mitamura, yasutaka, additional, Zink, Alexander, additional, and Schmid-Grendelmeier, Peter, additional
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- 2024
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40. Climate crisis paralysis: Accelerating global action for health resilience in a changing world
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Orasche, Jürgen, primary, Nadeau, Kari C., additional, Schuster, Antonia, additional, Rockström, Johan, additional, Akdis, Cezmi A., additional, and Traidl‐Hoffmann, Claudia, additional
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- 2024
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41. The impact of indoor pollution on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
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Agache, Ioana, primary, Canelo‐Aybar, Carlos, additional, Annesi‐Maesano, Isabella, additional, Cecchi, Lorenzo, additional, Biagioni, Benedetta, additional, Chung, Fan, additional, D'Amato, Gennaro, additional, Damialis, Athanasios, additional, Del Giacco, Stefano, additional, De las Vecillas, Leticia, additional, Dominguez‐Ortega, Javier, additional, Galàn, Carmen, additional, Gilles, Stefanie, additional, Giovannini, Mattia, additional, Holgate, Stephen, additional, Jeebhay, Mohamed, additional, Nadeau, Kari, additional, Papadopoulos, Nikos, additional, Quirce, Santiago, additional, Sastre, Joaquin, additional, Traidl‐Hoffmann, Claudia, additional, Walusiak‐Skorupa, Jolanta, additional, Sousa‐Pinto, Bernardo, additional, Salazar, Josefina, additional, Rodríguez‐Tanta, L. Yesenia, additional, Cantero, Yahveth, additional, Montesinos‐Guevara, Camila, additional, Song, Yang, additional, Alvarado‐Gamarra, Giancarlo, additional, Sola, Ivan, additional, Alonso‐Coello, Pablo, additional, Nieto‐Gutierrez, Wendy, additional, Jutel, Marek, additional, and Akdis, Cezmi A., additional
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- 2024
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42. B cell immune response to human bocaviruses
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Karaaslan, Cagatay, primary, Wirz, Oliver, additional, Tan, Ge, additional, Globinska, Anna, additional, Boonpiyathad, Tadech, additional, Hedman, Klaus, additional, Vaselek, Slavica, additional, Venermo, Maria Söderlund, additional, Jartti, Tuomas, additional, Akdis, Mubeccel, additional, and Akdis, Cezmi A., additional
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- 2024
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43. Dupilumab‐associated ocular surface disease is characterized by a shift from Th2/Th17 toward Th1/Th17 inflammation
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Thormann, Kathrin, primary, Lüthi, Anne‐Sophie, additional, Deniau, Felix, additional, Heider, Anja, additional, Cazzaniga, Simone, additional, Radonjic‐Hoesli, Susanne, additional, Lehmann, Mathias, additional, Schlapbach, Christoph, additional, Herzog, Elio L., additional, Kreuzer, Marco, additional, Zinkernagel, Martin S., additional, Akdis, Cezmi A., additional, Zysset‐Burri, Denise C., additional, Simon, Hans‐Uwe, additional, and Simon, Dagmar, additional
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- 2024
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44. The impact of outdoor pollution and extreme temperatures on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
- Author
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Agache, Ioana, primary, Canelo‐Aybar, Carlos, additional, Annesi‐Maesano, Isabella, additional, Cecchi, Lorenzo, additional, Rigau, David, additional, Rodríguez‐Tanta, L. Yesenia, additional, Nieto‐Gutierrez, Wendy, additional, Song, Yang, additional, Cantero‐Fortiz, Yahveth, additional, Roqué, Marta, additional, Vasquez, Juan Carlos, additional, Sola, Ivan, additional, Biagioni, Benedetta, additional, Chung, Fan, additional, D'Amato, Gennaro, additional, Damialis, Athanasios, additional, del Giacco, Stefano, additional, Vecillas, Leticia de las, additional, Dominguez‐Ortega, Javier, additional, Galàn, Carmen, additional, Gilles, Stefanie, additional, Giovannini, Mattia, additional, Holgate, Stephen, additional, Jeebhay, Mohamed, additional, Nadeau, Kari, additional, Papadopoulos, Nikos, additional, Quirce, Santiago, additional, Sastre, Joaquin, additional, Traidl‐Hoffmann, Claudia, additional, Walusiak‐Skorupa, Jolanta, additional, Sousa‐Pinto, Bernardo, additional, Alonso‐Coello, Pablo, additional, Salazar, Josefina, additional, Jutel, Marek, additional, and Akdis, Cezmi, additional
- Published
- 2024
- Full Text
- View/download PDF
45. Frequency of changes in immunoglobulins, B-cells, and B-regulatory cells in patients with allergic reactions to amoxicillin over time after the acute reaction.
- Author
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Fernández-Santamaría, Rubén, primary, Cassinello, Maria Salas, additional, Herrera, Gador Bogas, additional, Mayorga, Cristobalina, additional, Jaen, Maria Torres, additional, Akdis, Cezmi, additional, Akdis, Mubeccel, additional, and Van de Veen, Willem, additional
- Published
- 2024
- Full Text
- View/download PDF
46. Inhaled Corticosteroids in early COVID-19 -- a tale of many facets
- Author
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Klimek, Ludger, primary, Akdis, Cezmi, additional, Jutel, Marek, additional, Zuberbier, Torsten, additional, and Bousquet, Jean, additional
- Published
- 2024
- Full Text
- View/download PDF
47. Regulation of immune response genes in the skin of allergic and clinically tolerant individuals exposed to p‐phenylenediamine
- Author
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Meisser, Sanne S., primary, Mitamura, Yasutaka, additional, Altunbulakli, Can, additional, Bandier, Josefine, additional, Opstrup, Morten S., additional, Gadsbøll, Anne‐Sofie Ø., additional, Li, Manru, additional, Tan, Ge, additional, Akdis, Mubeccel, additional, Akdis, Cezmi A., additional, Geisler, Carsten, additional, Johansen, Jeanne D., additional, and Bonefeld, Charlotte M., additional
- Published
- 2024
- Full Text
- View/download PDF
48. Recent advances in the epithelial barrier theory
- Author
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Pat, Yagiz, primary, Yazici, Duygu, additional, D'Avino, Paolo, additional, Li, Manru, additional, Ardicli, Sena, additional, Ardicli, Ozge, additional, Mitamura, Yasutaka, additional, Akdis, Mübeccel, additional, Dhir, Raja, additional, Nadeau, Kari, additional, Agache, Ioana, additional, Ogulur, Ismail, additional, and Akdis, Cezmi A, additional
- Published
- 2024
- Full Text
- View/download PDF
49. Loss of regulatory capacity in Treg cells following rhinovirus infection
- Author
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Jansen, Kirstin, Wirz, Oliver F., van de Veen, Willem, Tan, Ge, Mirer, David, Sokolowska, Milena, Satitsuksanoa, Pattraporn, Message, Simon D., Kebadze, Tatiana, Glanville, Nicholas, Mallia, Patrick, Skiepko, Roman, Eljaszewicz, Andrzej, Moniuszko, Marcin, Cardoso, Carlos, Gern, James E., Papadopoulos, Nikolaos G., Akdis, Cezmi A., Johnston, Sebastian L., Nadeau, Kari C., and Akdis, Mübeccel
- Published
- 2021
- Full Text
- View/download PDF
50. Pathophysiology of Allergic Rhinitis
- Author
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Ceylan, Mehmet Emrah, Cingi, Cemal, Özdemir, Cevdet, Kücüksezer, Umut Can, Akdis, Cezmi A., Cingi, Cemal, editor, and Bayar Muluk, Nuray, editor
- Published
- 2020
- Full Text
- View/download PDF
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