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2. Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Author

Kayaaslan, Bircan, Hasanoğlu, İmran, Dalkıran, Ayça, Aydos, Ömer, Çınar, Güle, Akdemir-Kalkan, İrem, İnkaya, Ahmet Çağkan, Aydin, Mehtap, Çakir, Hatice, Yıldız, Jale, Kocabıyık, Özenir, Arslan, Sonay, Nallı, Bayram, Demir, Ömer, Singil, Sarp, Ataman-Hatipoğlu, Çiğdem, Tuncer-Ertem, Günay, Kınıklı, Sami, Önal, Uğur, Mete, Bilgül, Dalgan, Gözde, Taşbakan, Meltem, Yamazhan, Tansu, Kömürcüoğlu, Berna, Yalnız, Enver, Benli, Aysun, Keskin-Sarıtaş, Çağla, Ertosun, Mustafa Gökhan, Özkan, Özlenen, Emre, Salih, Arıca, Seçil, Kuşçu, Ferit, Candevir, Aslıhan, Ertürk-Şengel, Buket, Ayvaz, Fadime, Aksoy, Firdevs, Mermutluoğlu, Çiğdem, Demir, Yakup, Günlüoğlu, Gülşah, Tural-Önür, Seda, Kılıç-Toker, Ayşin, Eren, Esma, Otlu, Barış, Mete, Ayşe Özlem, Koçak, Kübra, Ateş, Hale, Koca-Kalkan, İlkay, Aksu, Kurtuluş, Tanriover, Mine Durusu, Doğanay, Hamdi Levent, Akova, Murat, Güner, Hatice Rahmet, Azap, Alpay, Akhan, Sıla, Köse, Şükran, Erdinç, Fatma Şebnem, Akalın, Emin Halis, Tabak, Ömer Fehmi, Pullukçu, Hüsnü, Batum, Özgür, Şimşek Yavuz, Serap, Turhan, Özge, Yıldırmak, Mustafa Taner, Köksal, İftihar, Taşova, Yeşim, Korten, Volkan, Yılmaz, Gürdal, Çelen, Mustafa Kemal, Altın, Sedat, Çelik, İlhami, Bayındır, Yaşar, Karaoğlan, İlkay, Yılmaz, Aydın, Özkul, Aykut, Gür, Hazal, and Unal, Serhat

Published
2021
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3. Evaluation of the Distribution and Antimicrobial Susceptibility of Gram-negative Bacteria Isolated from Blood Cultures in Heamatologic Febrile Neutropenia Attacks

Author

Çınar, Güle, primary, Öcal, Duygu, additional, Cengiz Seval, Güldane, additional, Akdemir Kalkan, İrem, additional, Gülten, Ezgi, additional, Mukime Sarıcaoğlu, Elif, additional, Güriz, Haluk, additional, Civriz Bozdağ, Sinem, additional, Toprak, Selami Koçak, additional, Kurt Yüksel, Meltem, additional, and Azap, Alpay, additional

Published
2022
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5. The Impact of Vaccination Among Hospitalized Patients with the Diagnosis of COVID-19.

Author

Yıldız, Yeşim, Özger, Hasan Selçuk, Acar, Ali, Seremet-Keskin, Ayşegül, Binay, Umut Devrim, Ünlü, Gülten, Bayram, Halim, Asan, Ali, Akça, Mustafa Özgür, Karamanlıoğlu, Dilek, İnan, Osman, Kaya, Şafak, Yıldırım, Çiğdem, Arslan, Yusuf, Kömür, Süheyla, Saygıdeğer, Yasemin, Kandemir, Fatma Özlem, Yaşar, Simge, Akdemir-Kalkan, İrem, and Tekin-Taş, Zeynep

Published
2023
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7. Repurposing Sitagliptin for COVID-19 in Adults: Clinical Benefits and An Approach for the Mechanism

Author

Çınar, Güle, primary, Coşgun Yazgan, Satı, additional, Elhan, Atilla Halil, additional, Akdemir Kalkan, İrem, additional, Gülten, Ezgi, additional, Ünal, Mehmet Altay, additional, Demir, Özgür, additional, Memikoğlu, Kemal Osman, additional, Birengel, Mehmet Serhat, additional, Karahan, Zeynep Ceren, additional, Nazır, Hasan, additional, Evren, Ebru, additional, and Azap, Alpay, additional

Published
2022
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8. Evaluation of the Knowledge, Attitudes and Behaviors of Pregnant Women on Tetanus Vaccination

Author

Cinar, Gule, primary, Akdemir-Kalkan, Irem, additional, Yilmaz-Karadag, Fatma, additional, Hocaoglu, Meryem, additional, Deniz, Secil, additional, Isik, Mehmet Emirhan, additional, Gulten, Ezgi, additional, Erdem-Kivrak, Esra, additional, Tuzun, Turkan, additional, Torun, Ayse, additional, Unlu, Gulten, additional, Uygun-Kizmaz, Yesim, additional, Akgul, Fethiye, additional, Arslan, Eyup, additional, Dindar, Kubra, additional, Dogan, Gamze, additional, Sari, Sema, additional, Bayindir, Zeynep, additional, Saricaoglu, Elif Mukime, additional, Kaplan-Atalay, Ebru, additional, Mert Cavnar, Ahmet, additional, and Haliloglu, Elif Nur, additional

Published
2022
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9. Factors associated with progression of depression, anxiety, and stress‐related symptoms in outpatients and inpatients with COVID ‐19: A longitudinal study

Author

Hoşgören Alıcı, Yasemin, primary, Çınar, Güle, additional, Hasanlı, Jamal, additional, Ceran, Selvi, additional, Onar, Deha, additional, Gülten, Ezgi, additional, Akdemir Kalkan, İrem, additional, Memikoğlu, Kemal Osman, additional, Çelik, Çaşit Olgun, additional, and Devrimci‐Ozguven, Halise, additional

Published
2022
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11. Comparison of Tenofovir Alafenamide and Entecavir Therapy in Patients with Chronic Hepatitis B Initially Treated with Tenofovir Disoproxil: A Retrospective Observational Survey

Author

Akdemir Kalkan, Irem, primary, Karasahin, Omer, additional, Sarigul, Figen, additional, Altunisik Toplu, Sibel, additional, Aladag, Murat, additional, Akgul, Fethiye, additional, Mete, Ayşe Ozlem, additional, Golbol, Abdullah, additional, Nazik, Selcuk, additional, Kömür, Süheyla, additional, Merve Oren, Meryem, additional, Yildiz, Yesim, additional, Demir, Yakup, additional, Ayhan, Merve, additional, Tasova, Yesim, additional, Bayındır, Yasar, additional, Dal, Tuba, additional, and Celen, Mustafa K., additional

Published
2022
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12. An indirect effect of COVID-19 pandemic: Increased pediatric perforated appendicitis rate due to delayed admission

Author

Ergün, Ergun, primary, Sözduyar, Sümeyye, additional, Gurbanova, Aynur, additional, Serttürk, Fırat, additional, Çiftçi, Ergin, additional, Özdemir, Halil, additional, Arga, Gül, additional, Kübra Konca, Hatice, additional, Çınar, Güle, additional, Akdemir Kalkan, İrem, additional, Gülten, Ezgi, additional, Selvi Can, Özlem, additional, Şen Akova, Birsel, additional, Suat Fitöz, Ömer, additional, Vatansever, Göksel, additional, Tekin, Deniz, additional, Göllü, Gülnur, additional, Bingöl-Koloğlu, Meltem, additional, Yağmurlu, Aydın, additional, Çakmak, Murat, additional, and Ateş, Ufuk, additional

Published
2021
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13. Gargle and Mouthwash Can Replace Nasopharyngeal Swab Sampling When Concentrated with a New Method for the Diagnosis of COVID-19

Author

APPAK, ÖZGÜR, ATİLLA, AYNUR, İNAN, DİLARA, Karakök, Taliha, AKDEMİR KALKAN, İREM, Günal Eneyli, Müge, METE, AYŞE ÖZLEM, ÇELİK, İLHAMİ, ERTÜRK, AYŞE, KOCAGÖZ, AYŞE SESİN, EREN KUTSOYLU, OYA ÖZLEM, ÇINAR, ECE, MERT, MERVE, TAŞBAKAN, MELTEM, Çinar, Canberk, TANRIVERDİ ÇAYCI, YELİZ, BOZDEMİR, TUĞBA, MUTLU, DERYA, Gülbahçe Orhan, Sul, KARAKOÇ, AYŞE ESRA, EVREN, EBRU, KARAHAN, ZEYNEP CEREN, ÇEKİN, YEŞİM, Sepin Özen, Nevgün, ZER, YASEMİN, KARSLIGİL, TEKİN, Saatci, Esma, AY ALTINTOP, YASEMİN, ÖZGÜMÜŞ, OSMAN BİROL, ÇOPUR ÇİÇEK, AYŞEGÜL, KÜLAH, CANAN, YURTTUTAN UYAR, NEVAL, SAYINER, AYÇA ARZU, ÇİÇEK, CANDAN, CAN, ÖZGE, CİRİT, OSMAN SEZER, MUTLU, ESVET, SANCAK, BANU, and KOCAGÖZ, ZÜHTÜ TANIL

Published
2021

16. Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Author

Tanriover, Mine Durusu, primary, Doğanay, Hamdi Levent, additional, Akova, Murat, additional, Güner, Hatice Rahmet, additional, Azap, Alpay, additional, Akhan, Sıla, additional, Köse, Şükran, additional, Erdinç, Fatma Şebnem, additional, Akalın, Emin Halis, additional, Tabak, Ömer Fehmi, additional, Pullukçu, Hüsnü, additional, Batum, Özgür, additional, Şimşek Yavuz, Serap, additional, Turhan, Özge, additional, Yıldırmak, Mustafa Taner, additional, Köksal, İftihar, additional, Taşova, Yeşim, additional, Korten, Volkan, additional, Yılmaz, Gürdal, additional, Çelen, Mustafa Kemal, additional, Altın, Sedat, additional, Çelik, İlhami, additional, Bayındır, Yaşar, additional, Karaoğlan, İlkay, additional, Yılmaz, Aydın, additional, Özkul, Aykut, additional, Gür, Hazal, additional, Unal, Serhat, additional, Kayaaslan, Bircan, additional, Hasanoğlu, İmran, additional, Dalkıran, Ayça, additional, Aydos, Ömer, additional, Çınar, Güle, additional, Akdemir-Kalkan, İrem, additional, İnkaya, Ahmet Çağkan, additional, Aydin, Mehtap, additional, Çakir, Hatice, additional, Yıldız, Jale, additional, Kocabıyık, Özenir, additional, Arslan, Sonay, additional, Nallı, Bayram, additional, Demir, Ömer, additional, Singil, Sarp, additional, Ataman-Hatipoğlu, Çiğdem, additional, Tuncer-Ertem, Günay, additional, Kınıklı, Sami, additional, Önal, Uğur, additional, Mete, Bilgül, additional, Dalgan, Gözde, additional, Taşbakan, Meltem, additional, Yamazhan, Tansu, additional, Kömürcüoğlu, Berna, additional, Yalnız, Enver, additional, Benli, Aysun, additional, Keskin-Sarıtaş, Çağla, additional, Ertosun, Mustafa Gökhan, additional, Özkan, Özlenen, additional, Emre, Salih, additional, Arıca, Seçil, additional, Kuşçu, Ferit, additional, Candevir, Aslıhan, additional, Ertürk-Şengel, Buket, additional, Ayvaz, Fadime, additional, Aksoy, Firdevs, additional, Mermutluoğlu, Çiğdem, additional, Demir, Yakup, additional, Günlüoğlu, Gülşah, additional, Tural-Önür, Seda, additional, Kılıç-Toker, Ayşin, additional, Eren, Esma, additional, Otlu, Barış, additional, Mete, Ayşe Özlem, additional, Koçak, Kübra, additional, Ateş, Hale, additional, Koca-Kalkan, İlkay, additional, and Aksu, Kurtuluş, additional

Published
2021
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18. Bir Sempozyuma Katılan Aile Hekimlerinin Aşı Uygulamaları Konusundaki Bilgilerinin Değerlendirilmesi

Author

Ören, Meryem Merve, Yıldız, Yeşim, Dal, Tuba, Taşova, Yeşim, and Akdemir Kalkan, İrem

Abstract

GİRİŞ ve AMAÇ: Koruyucu hekimliğin oldukça önemli bir parçasıolan bağışıklama uygulamalarında en temel görevler aile hekimlerinedüşmektedir.Batman ilinde aile hekimlerinin bağışıklama konusundakieğitim ve güncelleme ihtiyaçlarına yönelik Aralık 2019’da birsempozyum düzenlenmiştir. Bu çalışmanın amacı gerçekleştirilensempozyuma katılan birinci basamak hekimlerinin aşı uygulamalarıkonusundaki bilgi düzeylerini değerlendirmektir.YÖNTEM ve GEREÇLER: Çalışma tanımlayıcı nitelikte bir gözlemçalışması olarak planlanmıştır. Aile hekimi olarak görev yapmaktaolan 155 hekim bu sempozyuma katılmış olup 48 hekim anketidoldurmuştur. Sempozyum öncesinde aile hekimlerine demografiksorular ile birlikte aşı uygulamaları konusunda bilgi düzeyinietkileyebileceği düşünülen sorular ve bilgi tespitine yönelik 34 sorudanoluşan bir anket uygulanmıştır. Bilgi sorularının yanıtları doğru,yanlış veya bilmiyorum olarak seçeneklendirilmiştir.BULGULAR: Anket sorularını cevaplayanların 40’ı erkek, meslekteortalama çalışma süreleri 8±7,3 yıldır.Kişilerin yarısı bilgi ölçümüneyönelik sorulan 34 sorudan 23 ve üzerinde soruyu doğru cevaplamıştır,en az 9 soru (soruların %26,5’i) doğru cevaplanmıştır. Bir kişi isesoruların tamamını doğru cevaplamıştır.Meslekte çalışma süresi iledoğru cevap verilen soru sayısı arasında herhangi bir korelasyonsaptanmamıştır (r=-0,142 p=0,337).TARTIŞMA ve SONUÇ: Aşılar konusunda son dönemde giderek artantereddütleri gidermede en etkin yollardan biri hekim ve diğer sağlıkçalışanlarının, aşı uygulanacak bireyler ve ebeveynler ile iyi biriletişim kurması ve güven sağlamasıdır. Etkin bir iletişimisağlayabilmek için özellikle birinci basamak sağlık hizmeti veren ailehekimlerimizin bu konudaki bilgilerinin yeterli olması gerekmektedir.Bu nedenle aile hekimlerine yönelik bilgilendirici nitelikte toplantılarındüzenlenmesi güncel bilgi erişimi konusunda kolaylık sağlayacaktır.&nbsp

Published
2021

19. Real-life data for tenofovir alafenamide fumarate treatment of hepatitis B: The pythagoras cohort

Author

Tasova, Yesim, Oren, Meryem Merve, Akar, Fesih, Karasahin, Omer, Esmer, Fatih, AKDEMİR KALKAN, İREM, Tunc, Nurettin, Balin, Safak Ozer, Kandemir, Ozlem, Bayindir, Yasar, Inan, Dilara, Yildiz, YEŞİM, Sarigul, Figen, KÖMÜR, SÜHEYLA, Mete, Ayse Ozlem, Dal, Tuba, Demir, Yakup, Nazik, Selcuk, Akgul, Fethiye, Celen, Mustafa K., ALTUNIŞIK TOPLU, SİBEL, Kaya, Safak, Harputoglu, Murat, Ayhan, Merve, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı, Aktar, Fesih, and Çelen, Mustafa Kemal

Subjects
Tenofovir Alafenamide, Real life, Bone mineral density, virus diseases, Chronic Hepatitis B, Glomerular filtration rate, Hepatitis B, Tenofovir Disoproxil
Abstract

WOS:000635211600001 Background: Chronic hepatitis B (CHB) is a viral infection that can result in life-threatening conditions, such as hepatocellular carcinoma and cirrhosis. Tenofovir, which is used for the treatment of CHB, is a nucleotide analog that inhibits HBV-DNApolymerase and has two formulations: disoproxil and alafenamide. In contrast to tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF) penetrates the whole hepatocyte without being eliminated due to its longer plasma half-life and greater plasma stability. As a result, side effects such as proximal renal tubulopathy and loss of bone density are less common in the treatment of TAF and have similar efficacy to TDF. Objectives: The purpose of the study was to evaluate the effectiveness and reliability of TAF using real-life data. Methods: This retrospective cohort study was carried out in secondary or tertiary healthcare centers in southern Turkey. A total of 480 patients aged 18 years and older were administered TAF for an appropriate indication by the infectious diseases and gastroenterology clinics of the healthcare centers participating in this study. The data collected at t = 0, t =3, and t = 6 months of treatment were analyzed. The chi-square, Mann-Whitney U, Friedman, Wilcoxon, Cochran's Q, and McNemar's tests were used. Results: The mean age of the patients was 47.40 +/- 14.5, and 327 of them (68.1%) were male. A total of 78.1% of the 480 patients who underwent the TAF treatment had previous antiviral therapy experience (TDF, n =340; 70.8 %), and 21.9% were treatment-naive. The most common reasons for the initiation of TAF treatment were the use of drugs affecting bone mineral density (BMD) (42.9%) and osteoporosis (22.3%). Patients who had taken TDF experienced a significant improvement in glomerular filtration rate (GFR), hip and spine T-scores, and phosphorus levels from t = 0 months tot = 6 months after switching to TAF (P < 0.05). For this group, no statistically significant difference was observed concerning LDL and cholesterol levels from t= 0 months to t = 6 months. Side effects were reported by 5.7% of patients in the third month and 7.1% in the sixth month, with the most common side effect being hair loss (1%). Conclusions: TAF was found to be an effective and safe alternative to TDF with lower incidences of its long-term effects, such as nephrotoxicity and decreased bone density.

Published
2021

20. Occult hepatitis B infection in Turkish HIV‐infected patients: A multicentre, retrospective, cross‐sectional study, Schindler study

Author

Ünlü, Gülten, primary, Yıldız, Yeşim, additional, Ören, Meryem Merve, additional, Çabalak, Mehmet, additional, Mete, Özlem, additional, Kömür, Süheyla, additional, Yıldırım, Figen, additional, İnan, Dilara, additional, Altunışık Toplu, Sibel, additional, Akhan, Sıla, additional, Karaşahin, Ömer, additional, Akdemir Kalkan, İrem, additional, Demir, Yakup, additional, Ayhan, Merve, additional, Karaoğlan, İlkay, additional, Taşova, Yeşim, additional, Bayındır, Yaşar, additional, Dal, Tuba, additional, and Çelen, Mustafa Kemal, additional

Published
2021
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22. Gebelerin Tetanos Aşısıyla İlgili Bilgi, Tutum ve Davranışlarının Değerlendirilmesi.

Author

Çınar, Güle, Akdemir-Kalkan, İrem, Yılmaz-Karadağ, Fatma, Hocaoğlu, Meryem, Deniz, Seçil, Işık, Mehmet Emirhan, Gülten, Ezgi, Erdem-Kıvrak, Esra, Tüzün, Türkan, Torun, Ayşe, Ünlü, Gülten, Uygun-Kızmaz, Yeşim, Akgül, Fethiye, Arslan, Eyüp, Dindar, Kübra, Doğan, Gamze, Sarı, Sema, Bayındır, Zeynep, Sarıcaoğlu, Elif Mukime, and Kaplan-Atalay, Ebru

Subjects
*VACCINATION, *STATISTICS, *HEALTH education, *IMMUNIZATION, *COUNSELING, *ATTITUDES of mothers, *ATTITUDE (Psychology), *MULTIVARIATE analysis, *PREGNANT women, *HEALTH literacy, *TETANUS vaccines, *HEALTH behavior, *QUESTIONNAIRES, *VACCINE hesitancy
Abstract

Objective: Tetanus, a vaccine-preventable disease, still has the potential to threaten human health. Immunization, especially in pregnant women, is critical as it protects both mother and baby. This study aims to evaluate the tetanus immunization status of pregnant women, their approach to the vaccine, and the factors affecting these. Methods: A 19-item questionnaire was applied to pregnant women from all over Turkey who applied to the hospital for any reason and agreed to participate. Results: A total of5000 pregnant women from seven geographical regions, aged between 15 and 44 (mean 28±5.7) and whose gestational age was between 8 and 40 weeks (mean 22.07±8.5), participated in the study. %88.2 of them did not get vaccinated in their current pregnancy, and %23.2 of them didnt plan to get vaccinated. When the reasons for not being vaccinated were questioned, %28.6 and %15.4 of them were afraid of side effects and harming the baby, respectively. In addition, %23.9 of them thought they didn't need to be vaccinated, and %7.1 of them stated that the vaccine didn't provide any protection. In univariate analysis, regions, age, gestational week, and the number of pregnancies resulting in delivery were found as factors that statistically significantly affected getting vaccinated, but in multivariate analysis, gestational week, education until secondary school, being followed by a family physician, history of more than three pregnancies, and being vaccinated in a previous pregnancy was found as an independent factor. Conclusions: Neonatal tetanus should be prevented not only because of its high mortality but also, the sequelae, and it can be prevented, minimized, or even completely eradicated by vaccination of pregnant women. For this purpose, every pregnant woman should be informed, and education and counseling support should be provided for vaccination against tetanus. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Çocukluk çağı aşılarına yönelik ebeveyn tutumları ölçeğinin Türkçeye kültürel ve dil uyarlaması

Author

AKDEMİR KALKAN, İrem, ÖREN, Meryem Merve, KARASAHİN, Omer, YILDIZ, Yeşim, DEMİR, Yakup, DAL, Tuba, AKTAR, Fesih, BADUR, Selim, AYHAN, Merve, and ÇELEN, Mustafa Kemal

Subjects
Infectious Diseases, Aşı,aşı tereddüttü,validasyon,ölçek,tutum, Enfeksiyon Hastalıkları
Abstract

Amaç: Aşı tereddüdü hem Türkiye hem de dünya için toplumsal tehdit oluşturan bir tutumdur. Bu konuda Türkçeye validasyonu yapılmış bir ölçek bulunmamaktadır. Bu çalışmanın amacı Opel ve ark. tarafından 2011 yılında geliştirilip 2013 yılında revize edilen ve ‘Parent Attitudes About Childhood Vaccines Survey ‘isimli ölçeğin Türkçeye dil validasyonunun yapılmasıdır.Gereç ve Yöntem : Çalışma bir dil validasyonu çalışması olarak gerçekleştirilmiştir. Opel DJ ve arkadaşları tarafından geliştirilen ölçek için ‘Seri yöntem’ kullanılarak dil validasyonu çalışması yapılmıştır. Ölçeğin çeviri, gözden geçirme, geri çeviri, açıklığın ve aynılığın değerlendirmesi ile çevirisi sağlanmış ve Modifiye Lawshe yöntemiyle kapsam geçerlilik analizi yapılarak son hali verilmiştir. Uzmanların ölçek maddelerine yönelik içerik uygunluğu yönünden belirtmiş oldukları görüşlere göre her madde için kapsam geçerlilik oranı ve kapsam geçerlilik indeksi hesaplanmıştır.Bulgular. Tüm ölçek soruları için kapsam geçerlilik oranı kritik değer olan 0,455’in üzerinde saptanmıştır. Ölçeğin kapsam geçerlilik indeksi değeri ise 0,630 olup ölçek sorularının kapsam geçerliliğinin istatistiksel olarak anlamlı olduğu tespit edilmiştir.Çıkarımlar: Çocukluk çağı aşılarına yönelik ebeveyn tutumları ölçeğinin dil validasyonunun tamamlanması ve kapsam geçerlilik testlerinden istatistik olarak anlamlı sonuçlar alınmış olması bu ölçeğin Türkçe anlaşılırlığının sağlandığını göstermektedir. Sonrasında yapılacak geçerlilik ve güvenilirlik çalışmaları ile ölçeğin Türkiye’de aşı tereddüdü konusunda ebeveyn tutumlarını ölçebilir hale gelmesi hedeflenmektedir. Böylece daha geniş kitlelerde çalışılarak aşı tereddüdü ve mücadelesi konusunda yapılacak çalışmalara katkı sağlayacağı düşünülmektedir.

Published
2020

27. Assessment of Knowledge about Vaccination Practices of Family Physicians Participating in a Symposium

Author

Akgül, Fethiye, primary, Ören, Merve, additional, Akdemir Kalkan, İrem, additional, Yıldız, Yeşim, additional, Karaşahin, Ömer, additional, Aktar, Fesih, additional, Karabat, Mehmet Uğur, additional, Ayhan, Merve, additional, Demir, Yakup, additional, Dal, Tuba, additional, Taşova, Yeşim, additional, and Çelen, Mustafa Kemal, additional

Published
2021
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28. COVID-19 pneumonia and pneumothorax: case series

Author

Talan, Leyla, primary, Şaşal Solmaz, F. Gonca, additional, Ercan, Uğur, additional, Akdemir Kalkan, İrem, additional, Yenigün, Bülent Mustafa, additional, Yüksel, Cabir, additional, and Altıntaş, N. Defne, additional

Published
2020
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33. Evaluation of the Seroprevalence of Viral Hepatitis and the Human Immunodeficiency Virus Among Hospital Workers in Turkey and the Turkish Republic of Northern Cyprus

Author

Akdemir Kalkan, Irem, primary, Cinar, Gule, additional, Usturali Mut, Ayse Nur, additional, Karasahin, Omer, additional, Gurbuz, Yunus, additional, Tekin, Asiye, additional, Yuksel, Esma, additional, Suer, Kaya, additional, Ataman Hatipoglu, Cigdem, additional, Altun, Serife, additional, Cavlak, Halime, additional, Kocagul Celikbas, Aysel, additional, Azak, Emel, additional, Guler, Ozlem, additional, Ozturk Cerik, Hatun, additional, Bolukbasioglu, Ferah Ergin, additional, Mukime Saricioglu, Elif, additional, Sonmezer, Meliha Cagla, additional, Kul, Gulnur, additional, Sarlak Konya, Petek, additional, Can Sarica, Utku, additional, Torun, Ayse, additional, Devrim Binay, Umut, additional, Karakecili, Faruk, additional, Akgul, Fethiye, additional, Yildiz, Merve, additional, Inan, Dilara, additional, Batırel, Ayse, additional, Mustanoglu Ozatan, Duru, additional, Korkmaz, Pinar, additional, Isik, Mehmet Emirhan, additional, Uygun Kizmaz, Yesim, additional, Ulu, Yildiz, additional, Osman Memikoglu, Kemal, additional, and Azap, Alpay, additional

Published
2020
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38. İmmünsüpresif Tedavi Veren Hekimlerin Hepatit B Virüs Reaktivasyonuyla İlgili Farkındalıklarının ve Klinik Pratiklerinin Değerlendirilmesi

Author

ERSÖZ, GÜLDEN, HAKYEMEZ, İSMAİL NECATİ, AŞÇI, ZERRİN, YEŞİLBAĞ, ZUHAL, SAYAN, MURAT, KOCAGÜL ÇELİKBAŞ, AYSEL, GÜNDOĞDU, KIYMET, TOKA, ONUR, AYGEN, BİLGEHAN, ÇEKEN, SABAHAT, AYDIN, GÜLE, DEMİRTÜRK, NEŞE, KORKMAZ, PINAR, SÖNMEZER, MELİHA ÇAĞLA, AKHAN, SILA, GÜNEŞ ALTIPARMAK, VUSLAT ECEM, KADANALI, AYTEN, KÖSE, ŞÜKRAN, SÜMER, ŞUA, URAL, ONUR, ÖZTÜRK, SİNAN, HAYKIR SOLAY, ASLI, GÜNAL, ÖZGÜR, DİRGEN ÇAYLAK, SELMİN, AKTUĞ DEMİR, NAZLIM, CEYLAN, MEHMET REŞAT, ARSLAN, EYÜP, ACAR, ALİ, AYDIN, MEHTAP, KARAGÖZ, ERGENEKON, AYAZ, CELAL, ARSLAN ÖZEL, SELCAN, ÇETİNKAYA, RIZA AYTAÇ, YENİLMEZ, ERCAN, ŞENER, ALPER, SALTOĞLU, NEŞE, KURUÜZÜM, ZİYA, TEKİN, SÜDA, SÜER, HÜSEYİN KAYA, AKDEMİR KALKAN, İREM, ÖZKAYA, HACER DENİZ, TÜRKER, NESRİN, YÖRÜK, GÜLŞEN, YILMAZ KARADAĞ, FATMA, ÖRMEN, BAHAR, TÜLEK, NECLA, İNAN, DİLARA, EREN KUTSOYLU, OYA ÖZLEM, BATIREL, AYŞE, and SIRMATEL, FATMA

Published
2019

39. Awareness of hepatitis B virus reactivation among physicians administering immunosuppressive treatment and related clinical practices

Author

Koruk, Süda Tekin, Korkmaz, Pınar; Demirtürk, Neşe; Aydın, Güle; Çeken, Sabahat; Aygen, Bilgehan; Toka, Onur; Gündoğdu, Kıymet; Kocagül-Çelikbaş, Aysel; İnan, Dilara; Kuruüzüm, Ziya; Eren-Kutsoylu, Oya Özlem; Batırel, Ayşe; Sırmatel, Fatma; Ersöz, Gülden; Hakyemez, İsmail Necati; Aşçı, Zerrin; Yeşilbağ Zuhal; Sönmezer, Meliha Çağla; Tülek, Necla; Örmen, Bahar; Yılmaz-Karadağ, Fatma; Yörük, Gülşen; Türker, Nesrin; Özkaya, Hacer Deniz; Akdemir-Kalkan, İrem; Süer, Hüseyin Kaya; Saltoğlu, Neşe; Şener, Alper; Yenilmez, Ercan; Çetinkaya, Rıza Aytaç; Arslan-Özel, Selcan; Ayaz, Celal; Karagöz, Ergenekon; Aydın, Mehtap; Acar, Ali; Arslan, Eyüp; Ceylan, Mehmet Reşat; Aktuğ-Demir, Nazlım; Dirgen-Çaylak, Selmin; Günal, Özgür; Haykır-Solay, Aslı; Öztürk, Sinan; Ural, Onur; Sümer, Süa; Kadanalı, Ayten; Güneş-Altıparmak, Vuslat Ecem; Akhan, Sıla; Sayan, Murat; Köse, Şükran, Koç University Hospital, Koruk, Süda Tekin, Korkmaz, Pınar; Demirtürk, Neşe; Aydın, Güle; Çeken, Sabahat; Aygen, Bilgehan; Toka, Onur; Gündoğdu, Kıymet; Kocagül-Çelikbaş, Aysel; İnan, Dilara; Kuruüzüm, Ziya; Eren-Kutsoylu, Oya Özlem; Batırel, Ayşe; Sırmatel, Fatma; Ersöz, Gülden; Hakyemez, İsmail Necati; Aşçı, Zerrin; Yeşilbağ Zuhal; Sönmezer, Meliha Çağla; Tülek, Necla; Örmen, Bahar; Yılmaz-Karadağ, Fatma; Yörük, Gülşen; Türker, Nesrin; Özkaya, Hacer Deniz; Akdemir-Kalkan, İrem; Süer, Hüseyin Kaya; Saltoğlu, Neşe; Şener, Alper; Yenilmez, Ercan; Çetinkaya, Rıza Aytaç; Arslan-Özel, Selcan; Ayaz, Celal; Karagöz, Ergenekon; Aydın, Mehtap; Acar, Ali; Arslan, Eyüp; Ceylan, Mehmet Reşat; Aktuğ-Demir, Nazlım; Dirgen-Çaylak, Selmin; Günal, Özgür; Haykır-Solay, Aslı; Öztürk, Sinan; Ural, Onur; Sümer, Süa; Kadanalı, Ayten; Güneş-Altıparmak, Vuslat Ecem; Akhan, Sıla; Sayan, Murat; Köse, Şükran, and Koç University Hospital

Abstract

Objective: this study aimed to evaluate the awareness and knowledge levels of all physicians administering immunosuppressive treatment concerning hepatitis B virus (HBV) reactivation, and draw attention to the importance of the subject through evaluation. Methods: the study was carried out by infectious diseases and clinical microbiology specialists in 37 health centers, and it was performed in Turkey between January and March 2017. All specialists providing a written consent and working in the departments of Medical Oncology, Hematology, Dermatology and Venereology, Physical Medicine and Rehabilitation, and Rheumatology of each study center were included in the study. Results: a total of 430 physicians participated in the study. Their mean age was 39.87 +/- 7.42 years, and 47.9% of them were males. During their career, 39.3% of these physicians had encountered patients developing HBV reactivation while receiving immunosuppressive treatment. The rate of encountering patients who died due to HBV reactivation was 6.5%. 97% of physicians who participated, considered the risk of HBV reactivation to be important. 70.2% of physicians stated that guidelines related to HBV reactivation and antiviral treatment for these patients were discussed in the congresses they participated, regarding their specialties. The rate of performing hepatitis screening among physicians whose patients developed HBV reactivation was statistically significantly higher than those physicians who had no patients with HBV reactivation (p<0.05). Physicians who used the guidelines related to HBV reactivation in their specialties performed screening for the HBV infection much more often than physicians who did not use the guidelines (p=0.002). Conclusions: according to the results obtained in our study, the rates of conducting screening and awareness of HBV reactivation among physicians administering immunosuppressive treatment were higher compared with similar studies; however, their awareness that HBV, NA

Published
2019

44. Ülkemizde İmmunsupressif Tedavi Veren Hekimlerin Hepatit B Reaktivasyonu ile İlgiliFarkındalık ve Klinik Pratiklerinin Değerlendirilmesi

Author

İNAN, DİLARA, KOCAGÜL ÇELİKBAŞ, AYSEL, GÜNDOĞDU, KIYMET, TOKA, ONUR, AYGEN, BİLGEHAN, KUTSOYLU, OYA EREN, BATIREL, AYŞE, SIRMATEL, FATMA, ERSÖZ, GÜLDEN, HAKYEMEZ, İSMAİL NECATİ, AŞÇI, ZERRİN, YEŞİLBAĞ, ZUHAL, ÇAĞLA SÖNMEZER, MELİHA, TÜLEK, NECLA, ÖRMEN, BAHAR, YILMAZ KARADAĞ, FATMA, YÖRÜK, GÜLŞEN, TÜRKER, NESRİN, ÇEKEN, SABAHAT, ÇINAR AYDIN, GÜLE, ÖZKAYA, HACER DENİZ, DEMİRTÜRK, NEŞE, KORKMAZ, PINAR, AKDEMİR KALKAN, İREM, SUER, KAYA, TEKİN KORUK, SÜDA, SALTOĞLU, NEŞE, ŞENER, ALPER, YENİLMEZ, ERCAN, ÇETİNKAYA, RIZA AYTAÇ, ARSLAN ÖZEL, SELCAN, AYAZ, CELAL, KARAGÖZ, ERGENEKON, AYDIN, MEHTAP, ACAR, ALİ, ARSLAN, EYÜP, CEYLAN, MEHMET REŞAT, AKTUĞ DEMİR, NAZLIM, DİRGEN ÇAYLAK, SELMİN, GÜNAL, ÖZGÜR, HAYKIR SOLAY, ASLI, ÖZTÜRK, SİNAN, URAL, ONUR, SÜMER, ŞUA, KADANALI, AYTEN, GÜNEŞ ALTIPARMAK, VUSLAT ECEM, AKHAN, SILA, SAYAN, MURAT, KURUÜZÜM, ZİYA, and KÖSE, ŞÜKRAN

Published
2017

46. Awareness of hepatitis B virus reactivation among physicians administering immunosuppressive treatment and related clinical practices

Author

Sinan Ozturk, Onur Toka, Sabahat Ceken, Kiymet Gundogdu, Suda Tekin, Rıza Aytaç Çetinkaya, Nese Saltoglu, Gülden Ersöz, Ismail Necati Hakyemez, Sukran Kose, Selmin Dirgen Çaylak, Ziya Kuruüzüm, Nesrin Türker, Huseyin Kaya Suer, Zerrin Asci, Mehmet Reşat Ceylan, Alper Şener, Sua Sumer, Onur Ural, Ercan Yenilmez, Neşe Demirtürk, Aysel Kocagul Celikbas, Dilara Inan, Oya Özlem Eren Kutsoylu, Selcan Arslan Ozel, Asli Haykir Solay, Celal Ayaz, Özgür Günal, Eyup Arslan, İrem Akdemir Kalkan, Bilgehan Aygen, Ayse Batirel, Sıla Akhan, Mehtap Aydin, Bahar Ormen, Zuhal Yesilbag, Ergenekon Karagoz, Murat Sayan, Necla Tulek, Hacer Deniz Ozkaya, Gule Aydin, Ali Acar, Pinar Korkmaz, Fatma Yılmaz Karadağ, Vuslat Ecem Gunes Altiparmak, Ayten Kadanali, Nazlim Aktug Demir, Meliha Çağla Sönmezer, Gulsen Yoruk, Fatma Sirmatel, Koruk, Süda Tekin, Korkmaz, Pınar, Demirtürk, Neşe, Aydın, Güle, Çeken, Sabahat, Aygen, Bilgehan, Toka, Onur, Gündoğdu, Kıymet, Kocagül-Çelikbaş, Aysel, İnan, Dilara, Kuruüzüm, Ziya, Eren-Kutsoylu, Oya Özlem, Batırel, Ayşe, Sırmatel, Fatma, Ersöz, Gülden, Hakyemez, İsmail Necati, Aşçı, Zerrin, Yeşilbağ Zuhal, Sönmezer, Meliha Çağla, Tülek, Necla, Örmen, Bahar, Yılmaz-Karadağ, Fatma, Yörük, Gülşen, Türker, Nesrin, Özkaya, Hacer Deniz, Akdemir-Kalkan, İrem, Süer, Hüseyin Kaya, Saltoğlu, Neşe, Şener, Alper, Yenilmez, Ercan, Çetinkaya, Rıza Aytaç, Arslan-Özel, Selcan, Ayaz, Celal, Karagöz, Ergenekon, Aydın, Mehtap, Acar, Ali, Arslan, Eyüp, Ceylan, Mehmet Reşat, Aktuğ-Demir, Nazlım, Dirgen-Çaylak, Selmin, Günal, Özgür, Haykır-Solay, Aslı, Öztürk, Sinan, Ural, Onur, Sümer, Süa, Kadanalı, Ayten, Güneş-Altıparmak, Vuslat Ecem, Akhan, Sıla, Sayan, Murat, Köse, Şükran, Koç University Hospital, Selçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Demir, Nazlım Aktuğ, Sümer, Şua, MÜ, HAKYEMEZ, İSMAİL NECATİ, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü

Subjects
Microbiology (medical), Hepatitis B virus, Immunosuppressive treatment, reactivation, immunosuppression, business.industry, virus diseases, Medicine, general and internal, Microbiology, İmmünosüpresyon, Reaktivasyon, medicine.disease_cause, Reactivation, Hepatitis B, digestive system diseases, Infectious Diseases, Immunology, Medicine, KORKMAZ P., Demirturk N., Aydin G., Ceken S., AYGEN B., TOKA O., GÜNDOĞDU K., Kocagul-Celikbas A., İNAN D., KURUÜZÜM Z., et al., -Awareness of Hepatitis B Virus Reactivation Among Physicians Administering Immunosuppressive Treatment and Related Clinical Practices-, KLIMIK JOURNAL, cilt.32, ss.146-153, 2019, business, Immunosuppression
Abstract

Objective: this study aimed to evaluate the awareness and knowledge levels of all physicians administering immunosuppressive treatment concerning hepatitis B virus (HBV) reactivation, and draw attention to the importance of the subject through evaluation. Methods: the study was carried out by infectious diseases and clinical microbiology specialists in 37 health centers, and it was performed in Turkey between January and March 2017. All specialists providing a written consent and working in the departments of Medical Oncology, Hematology, Dermatology and Venereology, Physical Medicine and Rehabilitation, and Rheumatology of each study center were included in the study. Results: a total of 430 physicians participated in the study. Their mean age was 39.87 +/- 7.42 years, and 47.9% of them were males. During their career, 39.3% of these physicians had encountered patients developing HBV reactivation while receiving immunosuppressive treatment. The rate of encountering patients who died due to HBV reactivation was 6.5%. 97% of physicians who participated, considered the risk of HBV reactivation to be important. 70.2% of physicians stated that guidelines related to HBV reactivation and antiviral treatment for these patients were discussed in the congresses they participated, regarding their specialties. The rate of performing hepatitis screening among physicians whose patients developed HBV reactivation was statistically significantly higher than those physicians who had no patients with HBV reactivation (p, NA

Published
2019

47. COVID-19 pneumonia and pneumothorax: case series.

Author

Talan L, Şaşal Solmaz FG, Ercan U, Akdemir Kalkan İ, Yenigün BM, Yüksel C, and Altıntaş ND

Subjects
Aged, Aged, 80 and over, Diagnosis, Differential, Female, Hospitalization, Humans, Male, Mediastinal Emphysema diagnosis, Mediastinal Emphysema etiology, Middle Aged, Pneumothorax diagnosis, Pneumothorax etiology, Subcutaneous Emphysema diagnosis, Subcutaneous Emphysema etiology, COVID-19, Respiration, Artificial adverse effects, SARS-CoV-2
Abstract

Barotrauma is a commonly reported complication in critically ill patients with ARDS caused by different etiologies, it's rate is reported to be around %10. Pneumothorax/pneumomediastinum in COVID-19 patients seem to be more common and have different clinical characteristics. Here we report 9 patients who had pneumothorax and/or pneumomediastinum during their stay in the ICU. Patients who were admitted to ICU between March 2020 and December 2020, were reviewed for presence of pneumothorax, pneumomediastinum and subcutaneous emphysema during their ICU stay. Demographic characteristics, mechanical ventilation settings, documented ventilation parameters, outcomes were studied. A total of 161 patients were admitted to ICU during the study period, 96 were invasively ventilated. Nine patients had developed pneumothorax, pneumomediastinum and/or subcutaneous emphysema during their admission. Five of them were men and median age was 66.6 years. All patients were intubated and mechanically ventilated. All patients were managed conservatively. One patient was discharged from ICU, the others were lost due to other complications related to COVID-19. Upon detection of pneumothorax and/or mediastinum all patients were managed conservatively by limiting their PEEP and maximum inspiratory pressures and were followed by daily chest X-rays (CXR) for detection of any progress. None of the patients showed increase in size of their pneumothorax and/or pneumomediastinum. Hemodynamically instability due to pneumothorax and/or pneumomediastinum was not observed in any of the patients. Tension pneumothorax was not observed in any of the patients. Most common reason for death was sepsis due to secondary bacterial infections. Acute deterioration with rapid oxygen desaturation or palpation of crepitation over thorax and neck in a COVID-19 patient should prompt a search for pneumothorax or pneumomediastinum. Conservative management may be an option as long as the patients are stable.

Published
2020
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