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1. Epidemiological analysis of the victıms wıth crush syndrome in earthquakes of southeastern Turkey

Author

Ozturk, Ilyas, Gungor, Ozkan, Ozturk, Savas, Olmaz, Refik, Keskin, Ayse Jini Gunes, Kocyigit, Ismail, Sipahioglu, Murat Hayri, Dede, Fatih, Ulu, Sena, Turgutalp, Kenan, Torun, Dilek, Sahutoglu, Tuncay, Erdur, Fatih Mehmet, Altunoren, Orcun, Danis, Ramazan, Yildiz, Gursel, Gurel, Ali, Horoz, Mehmet, Kucuksu, Mehmet, Karakose, Suleyman, Yildirim, Tolga, Altiparmak, Mehmet Riza, Ayli, Mehmet Deniz, Tugcu, Murat, Eren, Zehra, Eroglu, Eray, Yavuz, Yasemin Coskun, Akcali, Esra, Sit, Dede, Polat, Mehmet, Yildirim, Saliha, Alagoz, Selma, Bek, Sibel Gokcay, Pembegul, Irem, Karaaslan, Tahsin, Keles, Mustafa, Sari, Funda, Yilmaz, Ustun, Gorgulu, Numan, Sahin, Gulizar, Aydin, Zeki, Yadigar, Serap, Ulutas, Ozkan, Selcuk, Nedim Yilmaz, Ayar, Yavuz, Turgut, Didem, Oto, Ozgur Akin, Koc, Mehmet, Yıldız, Alaattin, Tuglular, Serhan, and Sever, Mehmet Sukru

Published
2024
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2. Post-COVID-19 outcomes of non-dialysis dependent chronic kidney disease patients: a national, multicenter, controlled study

Author

Karadag, Serhat, Ozturk, Savas, Arici, Mustafa, Gorgulu, Numan, Akcali, Esra, Pembegul, Irem, Taymez, Dilek Guven, Kazancioglu, Rumeyza, Ayar, Yavuz, Mutluay, Ruya, Ozdemir, Arzu, Aydin, Zeki, Bashan, Yagmur, Alagoz, Selma, Yilmaz, Fatih, Trabulus, Sinan, Dirim, Ahmet Burak, Ozturk, Ilyas, Inci, Ayca, Azak, Alper, Aktas, Nimet, Kuzu, Tolga, Dheir, Hamad, Basturk, Taner, Ozler, Tuba Elif, Dincer, Mevlut Tamer, Turgutalp, Kenan, Ulu, Sena, Gungor, Ozkan, Bakir, Elif Ari, Odabas, Ali Riza, Seyahi, Nurhan, Yildiz, Alaattin, and Ates, Kenan

Published
2023
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3. Patients with crush syndrome and kidney disease: lessons learned from the earthquake in Kahramanmaraş, Türkiye

Author

Ozturk, Savas, Tuglular, Serhan, Olmaz, Refik, Kocyigit, Ismail, Kibar, Muge Uzerk, Turgutalp, Kenan, Torun, Dilek, Sahutoglu, Tuncay, Usalan, Ozlem, Gungor, Ozkan, Danis, Ramazan, Yildiz, Gursel, Gurel, Ali, Horoz, Mehmet, Kucuksu, Mehmet, Karakose, Suleyman, Yildirim, Tolga, Altiparmak, Mehmet Riza, Ayli, Mehmet Deniz, Tugcu, Murat, Eren, Zehra, Eroglu, Eray, Yavuz, Yasemin Coskun, Akcali, Esra, Sit, Dede, Polat, Mehmet, Yildirim, Saliha, Alagoz, Selma, Bek, Sibel Gokcay, Pembegul, Irem, Karaaslan, Tahsin, Keles, Mustafa, Sari, Funda, Inci, Ayca, Gorgulu, Numan, Sahin, Gulizar, Aydin, Zeki, Yadigar, Serap, Ulutas, Ozkan, Selcuk, Nedim Yilmaz, Ayar, Yavuz, Bal, Zeynep, Altunok, Murat, Günes Keskin, Ayse Jini, Sipahioglu, Murat Hayri, Ozkutlu, Meliha, Dursun, Belda, Oruc, Aysegul, Hasbal, Nuri Baris, Sevinc, Mustafa, Gul, Semih, Ozturk, Seda Safak, Yildiz, Alaattin, and Sever, Mehmet Sukru

Abstract

This study investigated in-hospital outcomes and related factors in patients diagnosed with postearthquake crush syndrome after the earthquakes in Kahramanmaraş, Türkiye. One thousand twenty-four adult patients diagnosed with crush syndrome were analyzed. Data on demographic characteristics, clinical presentation, laboratory values, treatments, and outcomes were collected. A total of 9.8% of patients died during their hospital stay. Nonsurvivors were generally older, more likely to have preexisting chronic kidney disease, and faced more severe injuries and complications, including hypotension-shock, arrhythmias, elevated markers of renal dysfunction, and higher rates of acute kidney injury (AKI) and compartment syndrome. In addition, intensive care unit needs were higher. Multivariate analysis confirmed that age, injury severity, shock, high potassium, uric acid, and lactate levels on admission, development of AKI, compartment syndrome, and intensive care unit admission were significant predictors of mortality. Better disaster preparedness and improved health care infrastructure could be potential explanations for improved in-hospital mortality in the current era, as compared to previous earthquakes.

Published
2024
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5. The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group

Author

Turgutalp, Kenan, Cebeci, Egemen, Turkmen, Aydin, Derici, Ulver, Seyahi, Nurhan, Eren, Necmi, Dede, Fatih, Gullulu, Mustafa, Basturk, Taner, Sahin, Gulizar Manga, Yilmaz, Murvet, Sipahi, Savas, Sahin, Garip, Ulu, Sena, Tatar, Erhan, Gundogdu, Ali, Kazancioglu, Rumeyza Turan, Sevinc, Can, Gungor, Ozkan, Sahin, İdris, Kutlay, Sim, Kurultak, Ilhan, Aydin, Zeki, Altun, Bulent, Dursun, Belda, Yilmaz, Zulfikar, Uzun, Ozcan, Suleymanlar, Gultekin, Candan, Ferhan, Sezer, Siren, Tanburoglu, Derya Basak, Bahcebasi, Zerrin Bicik, Taymez, Dilek, Akcali, Esra, Oygar, Deren, Istemihan, Zulal, Bardak, Simge, Akcay, Omer Faruk, Dincer, Mevlut Tamer, Dervisoglu, Erkan, Yenigun, Ezgi, Turkmen, Kultigin, and Ozturk, Savas

Published
2021
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6. Post-COVID-19 outcomes of non-dialysis dependent chronic kidney disease patients: a national, multicenter, controlled study

Author

Karadag, Serhat, primary, Ozturk, Savas, additional, Arici, Mustafa, additional, Gorgulu, Numan, additional, Akcali, Esra, additional, Pembegul, Irem, additional, Taymez, Dilek Guven, additional, Kazancioglu, Rumeyza, additional, Ayar, Yavuz, additional, Mutluay, Ruya, additional, Ozdemir, Arzu, additional, Aydin, Zeki, additional, Bashan, Yagmur, additional, Alagoz, Selma, additional, Yilmaz, Fatih, additional, Trabulus, Sinan, additional, Dirim, Ahmet Burak, additional, Ozturk, Ilyas, additional, Inci, Ayca, additional, Azak, Alper, additional, Aktas, Nimet, additional, Kuzu, Tolga, additional, Dheir, Hamad, additional, Basturk, Taner, additional, Ozler, Tuba Elif, additional, Dincer, Mevlut Tamer, additional, Turgutalp, Kenan, additional, Ulu, Sena, additional, Gungor, Ozkan, additional, Bakir, Elif Ari, additional, Odabas, Ali Riza, additional, Seyahi, Nurhan, additional, Yildiz, Alaattin, additional, and Ates, Kenan, additional

Published
2022
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7. Is the C4d, nephrin, and Wilms' tumor-1 staining pattern sensitive and specific for the differential diagnosis of focal segmental glomerulosclerosis and minimal change disease cases?

Author

Akcali, Esra, primary, Turgutalp, Kenan, additional, Karabulut, Yasemin Yuyucu, additional, Eser, Zeynep Ebru, additional, Mistik, Ozge Agtas, additional, Yilmaz, Banu Coskun, additional, Bardak, Simge, additional, Ozturk, Savas, additional, Demir, Serap, additional, and Kiykim, Ahmet Alper, additional

Published
2022
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9. MO219: Are C4D, Nephrın and WT1 Expressıons İmportant ın the Dıfferentıal Dıagnosıs between Focal Segmental Glomerulosclerosıs and Mınımal Change Dısease?

Author

Akcali, Esra, primary, Turgutalp, Kenan, additional, Yuyucu Karabulut, Yasemin, additional, Ebru Eser, Zeynep, additional, Agtas Mistik, Ozge, additional, Coskun Yılmaz, Banu, additional, Bardak, Simge, additional, Ozturk, Savas, additional, Demir, Serap, additional, and Kıykım, Ahmet, additional

Published
2022
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10. ACUTE KIDNEY INJURY IN HOSPITALIZED COVID-19 PATIENTS: A MULTICENTRE STUDY BY TURKISH SOCIETY OF NEPHROLOGY

Author

Kurultak, İlhan, Arıkan, İzzet Hakkı, Ozturk, Savas, Tokgöz, Bülent, Dursun, Belda, Seyahi, Nurhan, Trablus, Sinan, Islam, Mahmud, Ayar, Yavuz, Gorgulu, Numan, Karadag, Serhat, Gok, Mahmut, Akcali, Esra, Bora, Feyza, Aydin, Zeki, Altun, Eda, Sahutoglu, Tuncay, Oto, Ozgur Akin, Tuğlular, Zübeyde Serhan, Kara, Ekrem, Erkan, Sengul, Dal, Elbis Ahbap, Polat, Mehmet, Soypacaci, Zeki, Oguz, Ebru Gok, Boz, Gulsah, Koyuncu, Sümeyra, Colak, Hulya, Şahin, İdris, Dolarslan, Murside Esra, Helvaci, Ozant, Eren, Zehra, Dheir, Hamad, Ogutmen, Melike Betul, Taymez, Dilek Guven, Genek, Dilek Gibyeli, Özkurt, Sultan, Bakir, Elif Ari, and Yuksel, Enver

Abstract

BackgroundAcute kidney injury (AKI) is common in coronavirus disease-2019 (COVID-19) and theseverity of AKI is linked to adverse outcomes. In this study, we investigated the factors asso-ciated with in-hospital outcomes among hospitalized patients with COVID-19 and AKI.MethodsIn this multicenter retrospective observational study, we evaluated the characteristics andin-hospital renal and patient outcomes of 578 patients with confirmed COVID-19 and AKI.Data were collected from 34 hospitals in Turkey from March 11 to June 30, 2020. AKI defini-tion and staging were based on the Kidney Disease Improving Global Outcomes criteria.Patients with end-stage kidney disease or with a kidney transplant were excluded. Renaloutcomes were identified only in discharged patients.ResultsThe median age of the patients was 69 years, and 60.9% were males. The most frequentcomorbid conditions were hypertension (70.5%), diabetes mellitus (43.8%), and chronic kid-ney disease (CKD) (37.6%). The proportions of AKI stages 1, 2, and 3 were 54.0%, 24.7%,and 21.3%, respectively. 291 patients (50.3%) were admitted to the intensive care unit.Renal improvement was complete in 81.7% and partial in 17.2% of the patients who weredischarged. Renal outcomes were worse in patients with AKI stage 3 or baseline CKD. Theoverall in-hospital mortality in patients with AKI was 38.9%. In-hospital mortality rate was notdifferent in patients with preexisting non-dialysis CKD compared to patients without CKD(34.4 versus 34.0%, p = 0.924). By multivariate Cox regression analysis, age (hazard ratio[HR] [95% confidence interval (95%CI)]: 1.01 [1.0–1.03], p = 0.035], male gender (HR [95%CI]: 1.47 [1.04–2.09], p = 0.029), diabetes mellitus (HR [95%CI]: 1.51 [1.06–2.17], p =0.022) and cerebrovascular disease (HR [95%CI]: 1.82 [1.08–3.07], p = 0.023), serum lac-tate dehydrogenase (greater than two-fold increase) (HR [95%CI]: 1.55 [1.05–2.30], p =0.027) and AKI stage 2 (HR [95%CI]: 1.98 [1.25–3.14], p = 0.003) and stage 3 (HR [95%CI]:2.25 [1.44–3.51], p = 0.0001) were independent predictors of in-hospital mortality.ConclusionsAdvanced-stage AKI is associated with extremely high mortality among hospitalizedCOVID-19 patients. Age, male gender, comorbidities, which are risk factors for mortality inpatients with COVID-19 in the general population, are also related to in-hospital mortality inpatients with AKI. However, preexisting non-dialysis CKD did not increase in-hospital mor-tality rate among AKI patients. Renal problems continue in a significant portion of thepatients who were discharged.&nbsp

Published
2021

11. Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology

Author

Arikan, Hakki, primary, Ozturk, Savas, additional, Tokgoz, Bulent, additional, Dursun, Belda, additional, Seyahi, Nurhan, additional, Trabulus, Sinan, additional, Islam, Mahmud, additional, Ayar, Yavuz, additional, Gorgulu, Numan, additional, Karadag, Serhat, additional, Gok, Mahmut, additional, Akcali, Esra, additional, Bora, Feyza, additional, Aydın, Zeki, additional, Altun, Eda, additional, Ahbap, Elbis, additional, Polat, Mehmet, additional, Soypacacı, Zeki, additional, Oguz, Ebru Gok, additional, Koyuncu, Sumeyra, additional, Colak, Hulya, additional, Sahin, İdris, additional, Dolarslan, Murside Esra, additional, Helvacı, Ozant, additional, Kurultak, Ilhan, additional, Eren, Zehra, additional, Dheir, Hamad, additional, Ogutmen, Melike Betul, additional, Taymez, Dilek Guven, additional, Genek, Dilek Gibyeli, additional, Ozkurt, Sultan, additional, Bakır, Elif Ari, additional, Yuksel, Enver, additional, Sahutoglu, Tuncay, additional, Oto, Ozgur Akin, additional, Boz, Gulsah, additional, Sengul, Erkan, additional, Kara, Ekrem, additional, and Tuglular, Serhan, additional

Published
2021
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12. MO357ACUTE KIDNEY INJURY IN HOSPITALIZED COVID-19 PATIENTS: A MULTICENTRE STUDY BY TURKISH SOCIETY OF NEPHROLOGY

Author

Arıkan, İzzet Hakkı, primary, Ozturk, Savas, additional, Tokgoz, Bulent, additional, Dursun, Belda, additional, Seyahi, Nurhan, additional, Trablus, Sinan, additional, Islam, Mahmud, additional, Ayar, Yavuz, additional, Gorgulu, Numan, additional, Karadag, Serhat, additional, Gok, Mahmut, additional, Akcali, Esra, additional, Bora, Feyza, additional, Aydin, Zeki, additional, Altun, Eda, additional, Ahbap Dal, Elbis, additional, Polat, Mehmet, additional, Soypacaci, Zeki, additional, Gok Oguz, Ebru, additional, Koyuncu, Sumeyra, additional, Colak, Hulya, additional, Sahin, İdris, additional, Dolarslan, Murside Esra, additional, Helvacı, Özant, additional, Kurultak, Ilhan, additional, Eren, Zehra, additional, Dheir, Hamad, additional, OGUTMEN, MELIKE BETUL, additional, Guven Taymez, Dilek, additional, Gibyeli Genek, Dilek, additional, Ozkurt, Sultan, additional, Ari Bakir, Elif, additional, Yuksel, Enver, additional, Sahutoglu, Tuncay, additional, Oto, Ozgur Akin, additional, Boz, Gulsah, additional, Erkan, Sengul, additional, Kara, Ekrem, additional, and Tuglular, Z Serhan, additional

Published
2021
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13. IS THE SEVERITY OF GLOMERULAR IGG STAINING IN PATIENT WITH IGA NEPHROPATHY USEFUL FOR PREDICTING POOR RENAL PROGNOSIS? THE DATA FROM TSN-GOLD WORKING GROUP

Author

Turgutalp, Kenan, Cebeci, Egemen, Turkmen, Aydin, Derici, Ulver, Seyahi, Nurhan, Eren, Necmi, Dede, Fatih, Gullulu, Mustafa, Basturk, Taner, Sahin, Gulizar Manga, Yilmaz, Murvet, Sipahi, Savas, Sahin, Garip, Ulu, Memnune Sena, Tatar, Erhan, Gundogdu, Ali, Kazancioglu, Rumeyza Turan, Sevinc, Can, Gungor, Ozkan, Sahin, Idris, Kutlay, Sim, Kurultak, Ilhan, Aydin, Zeki, Altun, Bulent, Dursun, Belda, Yilmaz, Zulfikar, Uzun, Ozcan, Suleymanlar, Gultekin, Candan, Ferhan, Sezer, Siren, Tanburoglu, Derya Basak, Bahcebasi, Zerrin Bicik, Taymez, Dilek Guven, Oygar, Deren, Akcali, Esra, Istemihan, Zulal, Akcay, Omer Faruk, Dincer, Mevlut Tamer, Ergul, Metin, Yenigun, Ezgi, Kultigin Turkmen, Ozturk, Savas, and KAZANCIOĞLU, Rümeyza

Subjects
TURGUTALP K., Cebeci E., Turkmen A., DERİCİ Ü., SEYAHİ N., EREN N., Dede F., GÜLLÜLÜ M., Basturk T., Sahin G. M. , et al., -IS THE SEVERITY OF GLOMERULAR IGG STAINING IN PATIENT WITH IGA NEPHROPATHY USEFUL FOR PREDICTING POOR RENAL PROGNOSIS? THE DATA FROM TSN-GOLD WORKING GROUP-, 57th ERA-EDTA Congress, ELECTR NETWORK, 6 - 09 Haziran 2020, cilt.35, ss.800
Published
2020

15. P0490IS THE SEVERITY OF GLOMERULAR IGG STAINING IN PATIENT WITH IGA NEPHROPATHY USEFUL FOR PREDICTING POOR RENAL PROGNOSIS? THE DATA FROM TSN-GOLD WORKING GROUP

Author

Turgutalp, Kenan, primary, Cebeci, Egemen, primary, Turkmen, Aydin, primary, Derici, Ülver, primary, Seyahi, Nurhan, primary, Eren, Necmi, primary, Dede, Fatih, primary, Gullulu, Mustafa, primary, Basturk, Taner, primary, Manga Sahin, Gulizar, primary, Yılmaz, Mürvet, primary, Sipahi, Savas, primary, SAHIN, Garip, primary, Ulu, Memnune Sena, primary, Tatar, Erhan, primary, Gundogdu, Ali, primary, Turan Kazancioglu, Rumeyza, primary, Sevinc, Can, primary, Gungor, Ozkan, primary, Sahin, İdris, primary, Kutlay, Sim, primary, Kurultak, Ilhan, primary, Aydin, Zeki, primary, Altun, Bulent, primary, Dursun, Belda, primary, Yilmaz, Zulfikar, primary, Uzun, Ozcan, primary, Suleymanlar, Gultekin, primary, Candan, Ferhan, primary, Sezer, Siren, primary, Tanburoglu, Derya Basak, primary, Bicik Bahçebaşı, Zerrin, primary, Guven Taymez, Dilek, primary, Oygar, Deren, primary, Akcali, Esra, primary, Istemihan, Zulal, primary, Akcay, Omer Faruk, primary, Dincer, Mevlut Tamer, primary, Ergul, Metin, primary, Yenigun, Ezgi, primary, Turkmen, Kultigin, primary, and Ozturk, Savas, primary

Published
2020
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16. Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology

Author

Ebru Gok Oguz, Gulsah Boz, Feyza Bora, Numan Gorgulu, Mahmut Gok, Enver Yuksel, Serhat Karadag, Dilek Guven Taymez, Dilek Gibyeli Genek, Ekrem Kara, Eda Altun, Serhan Tuglular, Sultan Ozkurt, Melike Betul Ogutmen, Zeki Aydin, Elbis Ahbap, Belda Dursun, Zeki Soypacaci, Mehmet Polat, İdris Şahin, Mahmud Islam, Savas Ozturk, Sinan Trabulus, Murside Esra Dolarslan, Erkan Sengul, Esra Akcali, Hamad Dheir, Nurhan Seyahi, Elif Ari Bakir, Ozgur Akin Oto, Hakki Arikan, Tuncay Sahutoglu, Yavuz Ayar, Özant Helvacı, Zehra Eren, Ilhan Kurultak, Sumeyra Koyuncu, Bulent Tokgoz, Hulya Colak, ALKÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Arikan, Hakki, Ozturk, Savas, Tokgoz, Bulent, Dursun, Belda, Seyahi, Nurhan, Trabulus, Sinan, Islam, Mahmud, Ayar, Yavuz, Gorgulu, Numan, Karadag, Serhat, Gok, Mahmut, Akcali, Esra, Bora, Feyza, Aydin, Zeki, Altun, Eda, Ahbap, Elbis, Polat, Mehmet, Soypacaci, Zeki, Oguz, Ebru Gok, Koyuncu, Sumeyra, Colak, Hulya, Sahin, Idris, Dolarslan, Murside Esra, Helvaci, Ozant, Kurultak, Ilhan, Eren, Zehra, Dheir, Hamad, Ogutmen, Melike Betul, Taymez, Dilek Guven, Genek, Dilek Gibyeli, Ozkurt, Sultan, Bakir, Elif Ari, Yuksel, Enver, Sahutoglu, Tuncay, Oto, Ozgur Akin, Boz, Gulsah, Sengul, Erkan, Kara, Ekrem, Tuglular, Serhan, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Gibeyli Genek, Dilek, and RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü

Subjects
Male, Turkey, retrospective study, proportional hazards model, Comorbidity, urologic and male genital diseases, Biochemistry, intensive care unit, Severity of Illness Index, DISEASE, law.invention, hazard ratio, Medical Conditions, Endocrinology, CLINICAL CHARACTERISTICS, middle aged, Hospital Mortality, education.field_of_study, adult, Hazard ratio, Acute kidney injury, clinical trial, cohort analysis, WUHAN, aged, risk factor, Nephrology, Creatinine, diabetes mellitus, Medicine, disease severity, Infection, Wuhan, medicine.medical_specialty, hypertension, Death Rates, Endocrine Disorders, Science, causal attribution, complication, Article, Population Metrics, turkey (bird), Severity of illness, CKD, Renal Diseases, Ckd, Humans, human, education, Retrospective Studies, Biology and Life Sciences, Covid 19, sex ratio, medicine.disease, major clinical study, mortality, DIALYSIS PATIENTS, Health Care, hospital discharge, multicenter study, TRANSPLANT, sex factor, Health Care Facilities, observational study, Biomarkers, Dialysis Patients, Viral Diseases, mortality rate, Transplant, law, Risk Factors, INFECTION, Chronic Kidney Disease, Medicine and Health Sciences, Disease, Multidisciplinary, Mortality rate, chronic kidney failure, Acute Kidney Injury, Intensive care unit, Hospitals, virology, Hospitalization, hospital patient, Intensive Care Units, Infectious Diseases, female, Anatomy, Research Article, Population, coronavirus disease 2019, Sex Factors, acute kidney failure, blood, Internal medicine, medicine, Mortality, outcome assessment, Proportional Hazards Models, Population Biology, L-Lactate Dehydrogenase, business.industry, lactate dehydrogenase blood level, isolation and purification, SARS-CoV-2, disease association, COVID-19, Kidneys, lactate dehydrogenase, Renal System, Metabolic Disorders, pathology, business, Kidney disease, in-hospital mortality
Abstract

BackgroundAcute kidney injury (AKI) is common in coronavirus disease-2019 (COVID-19) and the severity of AKI is linked to adverse outcomes. In this study, we investigated the factors associated with in-hospital outcomes among hospitalized patients with COVID-19 and AKI.MethodsIn this multicenter retrospective observational study, we evaluated the characteristics and in-hospital renal and patient outcomes of 578 patients with confirmed COVID-19 and AKI. Data were collected from 34 hospitals in Turkey from March 11 to June 30, 2020. AKI definition and staging were based on the Kidney Disease Improving Global Outcomes criteria. Patients with end-stage kidney disease or with a kidney transplant were excluded. Renal outcomes were identified only in discharged patients.ResultsThe median age of the patients was 69 years, and 60.9% were males. The most frequent comorbid conditions were hypertension (70.5%), diabetes mellitus (43.8%), and chronic kidney disease (CKD) (37.6%). The proportions of AKI stages 1, 2, and 3 were 54.0%, 24.7%, and 21.3%, respectively. 291 patients (50.3%) were admitted to the intensive care unit. Renal improvement was complete in 81.7% and partial in 17.2% of the patients who were discharged. Renal outcomes were worse in patients with AKI stage 3 or baseline CKD. The overall in-hospital mortality in patients with AKI was 38.9%. In-hospital mortality rate was not different in patients with preexisting non-dialysis CKD compared to patients without CKD (34.4 versus 34.0%, p = 0.924). By multivariate Cox regression analysis, age (hazard ratio [HR] [95% confidence interval (95%CI)]: 1.01 [1.0–1.03], p = 0.035], male gender (HR [95%CI]: 1.47 [1.04–2.09], p = 0.029), diabetes mellitus (HR [95%CI]: 1.51 [1.06–2.17], p = 0.022) and cerebrovascular disease (HR [95%CI]: 1.82 [1.08–3.07], p = 0.023), serum lactate dehydrogenase (greater than two-fold increase) (HR [95%CI]: 1.55 [1.05–2.30], p = 0.027) and AKI stage 2 (HR [95%CI]: 1.98 [1.25–3.14], p = 0.003) and stage 3 (HR [95%CI]: 2.25 [1.44–3.51], p = 0.0001) were independent predictors of in-hospital mortality.ConclusionsAdvanced-stage AKI is associated with extremely high mortality among hospitalized COVID-19 patients. Age, male gender, comorbidities, which are risk factors for mortality in patients with COVID-19 in the general population, are also related to in-hospital mortality in patients with AKI. However, preexisting non-dialysis CKD did not increase in-hospital mortality rate among AKI patients. Renal problems continue in a significant portion of the patients who were discharged.

Published
2021

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