Search

A letter to the editor is presented in response to the article "Epidural Analgesia in Vascular Surgery Patients Actively Taking Clopidogrel," by W. A. Osta et al., published in a 2010 issue.

Care work is typically undervalued and precarious. However, little is currently known about the financial outcomes of immigrant women care workers as they reach post-retirement age, or their access to effective social policy supports. Using Canada as a case example, this study analyzes the Longitudinal Immigration Database to compare the income trajectories of women aged 65-95 who entered the country via the Care Worker immigration entry class to immigrant women from two other immigration streams (one focused on higher skill economic contributions, the other on family reunification). Estimating a series of growth curve models ( n = 28,775), results reveal that between 2007-2017, despite engaging in paid employment longer, Care Worker women were less able to make contributions to a private pension plan prior to retirement and more likely to depend on public pension benefits after reaching retirement age, relative to other immigrant women. Additionally, Care Worker women had lower predicted total income and experienced downward mobility during the post-retirement period. Together, the findings reinforce the importance of considering the financial circumstances of immigrant care workers as they age and highlight a need for renewed government investment in social supports to reduce inequalities tied to the gendered and racialized devaluation of low-wage caring occupations.

PX domains are found in a variety of proteins that associate with cell membranes, but their molecular function has remained obscure. We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3-phosphate (PtdIns(3)P), respectively. We also show that an Arg-to-Gln mutation in the PX domain of p47phox, which is found in patients with chronic granulomatous disease, eliminates phosphoinositide binding, as does the analogous mutation in the PX domain of p40phox. The PX domain of p40phox localizes specifically to PtdIns(3)P-enriched early endosomes, and this localization is disrupted by inhibition of phosphoinositide-3-OH kinase (PI(3)K) or by the Arg-to-Gln point mutation. These findings provide a molecular foundation to understand the role of PI(3)K in regulating neutrophil function and inflammation, and to identify PX domains as specific phosphoinositide-binding modules involved in signal transduction events in eukaryotic cells.