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6. Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese

Author

Nawata, Hajime, Shirasawa, Senji, Nakashima, Naoki, Araki, Eiichi, Hashiguchi, Jun, Miyake, Seibei, Yamauchi, Teruaki, Hamaguchi, Kazuyuki, Yoshimatsu, Hironobu, Takeda, Haruo, Fukushima, Hideo, Sasahara, Takayuki, Yamaguchi, Kohei, Sonoda, Noriyuki, Sonoda, Tomoko, Matsumoto, Masahiro, Tanaka, Yoshiya, Sugimoto, Hidekatsu, Tsubouchi, Hirotaka, Inoguchi, Toyoshi, Yanase, Toshihiko, Wake, Nakayasu, Narazaki, Kenziro, Eto, Takashi, Umeda, Fumio, Nakazaki, Mitsuhiro, Ono, Junko, Asano, Takashi, Ito, Yasuko, Akazawa, Shoichi, Hazegawa, Iwaho, Takasu, Nobuyuki, Shinohara, Moritsugu, Nishikawa, Takeshi, Nagafuchi, Seiho, Okeda, Toshimitsu, Eguchi, Katsumi, Iwase, Masanori, Ishikawa, Mayuko, Aoki, Masayuki, Keicho, Naoto, Kato, Norihiro, Yasuda, Kazuki, Yamamoto, Ken, and Sasazuki, Takehiko

Published
2004
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14. Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease

Author

Kawasaki, Eiji, Takino, Hirofumi, Yano, Mayumi, Uotani, Shigeo, Matsumoto, Kazunari, Takao, Yukio, Yamaguchi, Yoshihiko, Akazawa, Shoichi, and Nagataki, Shigenobu

Subjects
Autoantibodies -- Measurement -- Physiological aspects, Type 1 diabetes -- Physiological aspects -- Measurement, Glutamate decarboxylase -- Physiological aspects -- Measurement, Health, Physiological aspects, Measurement
Abstract

Autoantibodies to glutamic acid decarboxylase (GAD), previously reported to be the 64,000-[M.sub.r] (64K) islet cell protein, were measured by a radioimmunoassay using purified pig brain GAD in 29 insulin-dependent diabetes [...]

Published
1994

15. A case of isolated hypocalciuric hypercalcemia and type 2 diabetes mellitus followed by Grave's disease

Author

Tojikubo, Masayuki, Akazawa, Shoichi, Nakano, Yuko, Nakamura, Satoe, and Yamashita, Shunichi

Subjects
Grave's disease, Ca-sensing receptor, Familial hypocalciuric hypercalcemia, type 2 diabetes mellitus
Abstract

A 73-year-old woman was found to have diabetes mellitus along with elevated levels of calcium and alkaline phosphatase. She had also sometimes exhibited slight elevation of parathyroid hormone (97 pg/ml) while receiving treatment for hypertension and heart failure with atrial fibrillation, which had been detected by the Department of Cardiology at 71 years of age. She was admitted with elevated blood glucose (422 mg/dl) and hemoglobin A1c (12%) levels, as well as for further assessment of hyperparathyroidism. Her diabetes was treated with intensive insulin therapy (insulin lispro at 24 U per day). Assessment of hypercalcemia revealed that urinary calcium excretion was extremely low (0 mg/day) and the fractional excretion of Ca (FECa) was 0%. Familial hypocalciuric hypercalcemia was suspected. No abnormalities of the parathyroid gland were found by ultrasonography and 99mTc+Tl scintigraphy. The patient and her family members did not have any mutations in the extracellular domain or transmembrane domain of the calcium-sensing receptor, which has been reported to play an important role in Ca binding and intracellular signaling. However, the patient did have a missense mutation of codon 990 (R990G) in the intracellular domain, which has been reported to be a site of polymorphism, as well as a mutation of intron 6 (16 base pairs downstream from the exon-intron boundary: IVS6+16). One year later, she developed Grave's disease that presented with fatigue and weight loss., Acta medica Nagasakiensia, 59(1), pp.27-31; 2014

Published
2014

17. Abstracts of the Eighth Annual Meeting of the Japanese Society for Bone Metabolism Research

Author

Yoshikawa, Seizo, Machida, Hideto, Okamoto, Sumiaki, Akazawa, Shoichi, Usa, Toshitaka, Maeda, Renju, Takaoka, Yoshito, Takahashi, Hideaki, Yanagi, Kyozo, Togawa, Yutaka, Konno, Toshiyuki, Norimatsu, Hiromichi, Eguchi, Masao, Sugioka, Yoichi, Kaibara, Nobuhiro, Abe, Shiro, Marui, Shunichi, Esaki, Masataka, Omiya, Kenro, Tsuchiya, Yutaka, Kumagai, Michio, Matsuo, Nobutake, Yasaka, Atsushi, Tsuruta, Toyoshi, Kamiya, Hitoshi, Tsurumi, Nobuo, Shimizu, Koichi, Numazawa, Yoshiki, Kiyokawa, Michio, Sano, Yoshitaka, Katsunuma, Hideyo, Kanai, Nobue, Takizawa, Chizuko, Ohata, Masahiro, Fujita, Takuo, Yoshikawa, Masaki, Itaya, Hiroaki, Kinoshita, Katsuhiro, Ono, Reiji, Yamashita, Moriaki, Mori, Takemi, Morii, Hirotoshi, Hamada, Noboru, Nishizawa, Yoshiki, Okamoto, Teruo, Wada, Masahira, Ochi, Hironobu, Yoshida, Masahiko, Ohno, Joji, Takahashi, Toshihiro, Itoigawa, Yukinobu, Izawa, Kazumithu, Nakano, Kengo, Sakurai, Osamu, Inamathu, Noboru, Wakana, Ichiro, Inoue, Seishi, Hyowi, Son, Takeshi, Haruyama, Hiroshi, Kaneda, Hida, Wataru, Son, Hyowi, Haruyama, Takeshi, Kaneda, Hiroshi, Okazawa, Tsutomu, Suda, Akio, Ota, Kazuo, Sugino, Nobuhiro, Sadamitsu, Shunji, Shirasu, Hisao, Morisaki, Naoki, Amitani, Katsumasa, Matsui, Kiyoaki, Hamada, Hideki, Takaoka, Kunio, Nakata, Yozo, Nagai, Jun, Akiyama, Yasutaka, Oka, Masanori, Hirotani, Hayato, Hamanishi, Chiaki, Ito, Tetsuo, Nogami, Hiroshi, Terashima, Yoji, Urist, Marshall R., Kusuhara, S., Inoue, Seiichi, Takagi, Katsumasa, Iwamasa, Teruo, Takata, Kohei, Yamamoto, Kichizo, Ikeda, Katsumi, Lin, Shou-ben, Hikima, Toru, Hwang, An-Shin, Ueha, Takao, Kumegawa, Masayoshi, Masuda, Takeshi, Matsuno, Shigeo, Okamoto, Masatoshi, Imai, Yoh, Yoshiki, Shusaku, Tohda, Hisako, Chiba, Ikuyo, Suzuki, Mitsugu, Kodera, Masakatsu, Sato, Kozo, Wakamatsu, Eikichi, Kusakabe, Akira, Okamoto, Toshio, Hasegawa, Kiyoshi, Mori, Shigeru, Yonaga, Takara, Morita, Kumiko, Noguchi, Etsuko, Ueda, Juro, Karube, Shunji, Hayashi, Yasufumi, Igarashi, Mitsuo, Karube, Shunji, Takizawa, Hiroshi, Masuda, Mineo, Okitsu, Katsuhiko, Yoshino, Shinichi, Kuboki, Yoshinori, Shimokawa, Hitoyata, Kato, Susumu, Sasaki, Satoshi, Oguchi, Haruhisa, Mechanic, Gerald L., Fujita, Takuo, Hoshino, Takashi, Ikezaki, Ryozo, Itami, Yasuto, Inoue, Tetsuro, Akamatsu, Noriya, Suzuki, Kiyoyuki, Matsuzaki, Shigeru, Abe, Kyoju, Fukui, Sachiko, Shigemasa, Chiaki, Hirata, Yukimasa, Ogura, Yosuke, Sakai, Soichi, Kawaguchi, Yoshindo, Yamamoto, Masaru, Kimura, Yasuo, Oda, Yoshitaka, Ueda, Yasushi, Kushida, Kazuhiro, Mori, Manabu, Ushigome, Shinichiro, Hirotoni, Hayato, and Uyeo, Toyoji

Published
1975
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18. Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima‐media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes

Author

Akazawa, Shoichi, primary, Tojikubo, Masayuki, additional, Nakano, Yuko, additional, Nakamura, Satoe, additional, Tamai, Hidekazu, additional, Yonemoto, Koji, additional, Sadasima, Eiji, additional, Kawasaki, Tomohiro, additional, and Koga, Nobuhiko, additional

Published
2015
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19. Pregnancy outcomes in women with type 1 and type 2 diabetes mellitus in a retrospective multi-institutional study in Japan

Author

Sato, Takahiro, primary, Sugiyama, Takashi, additional, Kurakata, Michiyo, additional, Saito, Masatoshi, additional, Sugawara, Junichi, additional, Yaegashi, Nobuo, additional, Sagawa, Norimasa, additional, Sanaka, Mayumi, additional, Akazawa, Shoichi, additional, Anazawa, Sonoko, additional, Waguri, Masako, additional, Sameshima, Hiroshi, additional, Hiramatsu, Yuji, additional, and Toyoda, Nagayasu, additional

Published
2014
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20. Pregnancy outcomes of gestational diabetes mellitus according to pre-gestational BMI in a retrospective multi-institutional study in Japan

Author

Sugiyama, Takashi, primary, Nagao, Kenji, additional, Metoki, Hirohito, additional, Nishigori, Hidekazu, additional, Saito, Masatoshi, additional, Tokunaga, Hideki, additional, Nagase, Satoru, additional, Sugawara, Junichi, additional, Watanabe, Yoh, additional, Yaegashi, Nobuo, additional, Sagawa, Norimasa, additional, Sanaka, Mayumi, additional, Akazawa, Shoichi, additional, Anazawa, Sonoko, additional, Waguri, Masako, additional, Sameshima, Hiroshi, additional, Hiramatsu, Yuji, additional, and Toyoda, Nagayasu, additional

Published
2014
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22. Effects of brief exposure to insulin-induced hypoglycemic serum during organogenesis in rat embryo culture

Author

Akazawa, Mihoko, Akazawa, Shoichi, Hashimoto, Masumi, Akashi, Masaharu, Yamazaki, Hironori, Tahara, Daigo, Yamamoto, Hidefumi, Yamaguchi, Yoshihiko, Nakanishi, Toshiaki, and Nagataki, Shigenobu

Subjects
Teratogenesis -- Causes of -- Research -- Physiological aspects, Insulin -- Physiological aspects -- Research, Hypoglycemia -- Research, Health, Physiological aspects, Research, Causes of
Abstract

Effects of Brief Exposure to Insulin-Induced Hypoglycemic Serum During Organogenesis in Rat Embryo Culture We have previously shown that long-term exposure to medium containing insulin-induced hypoglycemic serum during the early [...]

Published
1989

24. Autoantibodies to Multiple Islet Autoantigens in Patients with Abrupt Onset Type 1 Diabetes and Diabetes Diagnosed with Urinary Glucose Screening

Author

Sera, Yasunori, primary, Kawasaki, Eiji, additional, Abiru, Norio, additional, Ozaki, Masako, additional, Abe, Takahiro, additional, Takino, Hirofumi, additional, Kondo, Hideaki, additional, Yamasaki, Hironori, additional, Yamaguchi, Yoshihiko, additional, Akazawa, Shoichi, additional, Nagataki, Shigenobu, additional, Uchigata, Yasuko, additional, Matsuura, Nobuo, additional, and Eguchi, Katsumi, additional

Published
1999
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27. Oxygen-Induced Embryopathy and the Significance of Glutathione-Dependent Antioxidant System in the Rat Embryo During Early Organogenesis

Author

Ishibashi, Miwa, primary, Akazawa, Shoichi, additional, Sakamaki, Hiroyuki, additional, Matsumoto, Kazunari, additional, Yamasaki, Hironori, additional, Yamaguchi, Yoshihiko, additional, Goto, Shinji, additional, Urata, Yoshishige, additional, Kondo, Takahito, additional, and Nagataki, Shigenobu, additional

Published
1997
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29. TNF-α stimulates glucose uptake in L6 myoblasts

Author

Yamasaki, Hironori, primary, Yamaguchi, Yoshihiko, additional, Takino, Hirofumi, additional, Matsuo, Hiroshi, additional, Matsumoto, Kazunari, additional, Uotani, Shigeo, additional, Akazawa, Shoichi, additional, Yamashita, Shunichi, additional, and Nagataki, Shigenobu, additional

Published
1996
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31. Autoantibodies to Glutamic Acid Decarboxylase in Patients with Autoimmune Thyroid Disease: Relation to Competitive Insulin Autoantibodies

Author

Kawasaki, Eiji, primary, Abiru, Norio, additional, Yano, Mayumi, additional, Uotani, Shigeo, additional, Matsumoto, Kazunari, additional, Matsuo, Hiroshi, additional, Yamasaki, Hironori, additional, Yamamoto, Hidefumi, additional, Yamaguchi, Yoshihiko, additional, Akazawa, Shoichi, additional, and Nagataki, Shigenobu, additional

Published
1995
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33. Insulin response after treatment depends on fasting plasma glucose level in NIDDM

Author

Matsumoto, Kazunari, primary, Akazawa, Shoichi, additional, Abiru, Norio, additional, Yano, Mayumi, additional, Ishibasi, Miwa, additional, Uotani, Shigeo, additional, Matsuo, Hiroshi, additional, Kawasaki, Eiji, additional, Yamasaki, Hironori, additional, Yamamoto, Hidefumi, additional, Yamaguchi, Yoshihiko, additional, and Nagataki, Shigenobu, additional

Published
1994
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34. Evaluation of Islet-Specific Autoantibodies in Japanese Patients with Insulin-Dependent Diabetes Mellitus: A Comparison between Autoantibodies to Glutamic Acid Decarboxylase, Autoantibodies to 64 kDa Islet Cell Protein and Islet Cell Antibodies

Author

Kawasaki, Eiji, primary, Takino, Hirofumi, additional, Yano, Mayumi, additional, Uotani, Shigeo, additional, Matsumoto, Kazunari, additional, Yamaguchi, Yoshihiko, additional, Akazawa, Shoichi, additional, and Nagataki, Shigenobu, additional

Published
1994
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35. Molecular analysis of insulin receptor gene in Werner's syndrome

Author

Uotani, Shigeo, primary, Yamaguchi, Yoshihiko, additional, Yokota, Atsushi, additional, Yamasaki, Hironori, additional, Takino, Hirofumi, additional, Chikuba, Nobuhiro, additional, Goto, Yoshiki, additional, Fujishima, Naoki, additional, Yano, Mayumi, additional, Matsumoto, Kazunari, additional, Kawasaki, Eiji, additional, Akazawa, Shoichi, additional, and Nagataki, Shigenobu, additional

Published
1994
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38. The Heterogeneity of Whole Islet Cell Cytoplasmic Antibodies Evidenced by Absorption Test with Glutamic Acid Decarboxylase

Author

Takino, Hirofumi, primary, Kawasaki, Eiji, additional, Yano, Mayumi, additional, Matsumoto, Kazunari, additional, Uotani, Shigeo, additional, Okuno, Shinichiro, additional, Takao, Yukio, additional, Yamasaki, Hironori, additional, Yamaguchi, Yoshihiko, additional, Akazawa, Shoichi, additional, and Nagataki, Shigenobu, additional

Published
1994
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41. Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Thyroid Disease in Japan.

Author

CHIKUBA, Nobuhiro, primary, AKAZAWA, Shoichi, additional, YAMAGUCHI, Yoshihiko, additional, KAWASAKI, Eiji, additional, TAKINO, Hirofumi, additional, TAKAO, Yukio, additional, MAEDA, Yasuo, additional, OKUNO, Shinichiro, additional, YAMAMOTO, Hidefumi, additional, YOKOTA, Atsushi, additional, YOSHIMOTO, Masaaki, additional, and NAGATAKI, Shigenobu, additional

Published
1992
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47. Expression of Recombinant Human Glutamic Acid Decarboxylase (GAD) in Myeloma Cells and Enzyme-Linked Immunosorbent Assay (ELISA) for Autoantibodies to GAD.

Author

Matsuba, Takao, Yano, Mayumi, Abiru, Noriu, Takino, Hirofumi, Akazawa, Shoichi, Nagataki, Shigenobu, and Yasukawa, Kiyoshi

Subjects
GLUTAMIC acid, GLUTAMATE decarboxylase, AUTOANTIBODIES, MYELOMA proteins, ENZYME-linked immunosorbent assay
Abstract

Detection of serum autoantibodies to glutamic acid decarboxylase (GAD) is a new method to differentiate insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NTDDM). We established a transformed mouse myeloma cell line, SPG14, which expresses recombinant human GAD65, a major isomer of 65 kDa, inside the cells. GAD65 was partially purified by affinity chromatography using the mouse anti-GAD antibody (Ab). We also established a sandwich ELISA for anti-GAD Ab of the IgG class using GAD65 for coating and the anti-human IgG for detection and examined 54 sera of the IDDM patients and 45 sera of normal individuals. When the mean+2 SD of the color development of the sera of normal individuals was used as a cut-off level, 59.2% of patients with DDDM were positive. This indicates that the ELISA was effective to differentiate D3DM and NDDDM. The result also indicates that the autoantibody to GAD does not dissociate from the recombinant GAD rapidly, even when unbound anti-GAD Ab was fully removed. By using a perfusion culture system, we obtained as many as 4.2 ×1010 SPG14 cells, from which 5 mg of GAD65 could be obtained; this is sufficient for 5,000 assays. This system could be clinically useful for large-scale diagnosis of IDDM. [ABSTRACT FROM AUTHOR]

Published
1997
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48. Clinical Evaluation of Non-Insulin-Dependent Diabetes Mellitus Patients with Autoantibodies to Glutamic Acid Decarboxylase

Author

Abiru, Norio, Takino, Hirofumi, Yano, Mayumi, Kawasaki, Eiji, Yamasaki, Hironori, Yamaguchi, Yoshihiko, Akazawa, Shoichi, and Nagataki, Shigenobu

Abstract

We evaluated the frequency of antibodies to glutamic acid decarboxylase (GAD-Ab) in Japanese patients diagnosed initially as having non-insulin-dependent diabetes mellitus (NIDDM) and investigated a possible link between the presence of GAD-Ab and development of the insulin-dependent (ID) state. The population sample consisted of 583 Japanese NIDDM patients (age at onset >30 years) who were initially non-ketotic and did not require insulin treatment during at least 6 months of observation. GAD-Ab were measured using radioimmunoassay. The clinical characteristics of GAD-Ab+patients were carefully examined at four-year intervals from the onset of diabetes. We also examined the ID state by measuring the level of postprandial serum C-peptide and i.v. glucagon-stimulated serum C-peptide. The overall prevalence of GAD-Ab in Japanese NIDDM patients was 3.8%. The frequency of GAD-Ab+did not significantly decrease with a long history of diabetes. GAD-Ab+patients had a lower body mass index, compared with GAD-Ab−(20.8±2.9 vs 23.0±3.7,P<0.005), lower postprandial C-peptide levels (0.7±0.6 vs 1.4±1.2,P<0.01), and an early commencement of insulin therapy (3.6±4.7 vs 8.3±6.6,P<0.01). GAD-Ab+patients who had already developed the ID state had characteristically higher titers of GAD-Ab (421.4±359.1) and a higher frequency of islet cell antibodies (ICAs) (77.8%), compared with GAD-Ab+NID patients (titer: 60.2±86.9,P<0.005, 23.1%,P<0.05, respectively). GAD-Ab+ICAs+patients showed higher frequencies of ID state at any diabetic duration compared with GAD−ICAs−, while GAD-Ab+ICAs−patients did not differ in the frequency of the ID state from GAD−ICAs−. Our results suggest that the presence of both GAD-Ab and ICAs represents a high risk for IDDM in GAD-Ab+NIDDM patients.

Published
1996
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50. Changes of serum thyroid hormone levels induce malformations on early embryogenesis in rats

Author

Harakawa, Seijiro, Akazawa, Shoichi, Akazawa, Mihoko, Hashimoto, Masumi, Yamashita, Shunichi, Izumi, Motomori, and Nagataki, Shigenobu

Abstract

The incidence of malformation is increased in infants of hyperthyroid or hypothyroid woman. Although many papers reported that the fetus is insulted from maternal thyroid hormone, the placenta (maternalfetal barrier) is not yet fully developed before 11.5 days of gestation in rat embryos, suggesting the effect of thyroid hormone on early rat embryogenesis. This study was, therefore, undertaken to investigate whether excess or lack of thyroid hormones would affect early embryogenesis in rat embryo culture. Malformations including open neuropore and microencephaly were observed in 10 of 30 embryos incubated in hyperthyroid serum, and in 12 of 42 cultured in T3-enriched normal serum. Similar malformations were observed in 14 of 42 embryos cultured in hypothyroid serum and in 10 of 30 cultured in hypothyroid serum supplemented with T3. The frequencies of these malformations were significantly higher than in the control embryos (0 in 72 embryos) cultured with normal rat serum. These results suggest that the maternal thyroid status might play an important role for the complication of fetal malformations during early gestational period.

Published
1989
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