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49 results on '"Akasaka, Risaburo"'

7. A case of a stuck mesh in the rectum after pelvic surgery

Author

Eizuka, Makoto, primary, Toya, Yosuke, additional, Akasaka, Risaburo, additional, Yamada, Shun, additional, Oizumi, Tomofumi, additional, Kasugai, Satoshi, additional, Yanai, Shunichi, additional, Sugimura, Yoshihiko, additional, and Matsumoto, Takayuki, additional

Published
2023
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16. The mucin phenotype does not affect the endoscopic resection outcome of non-ampullary duodenal epithelial tumors

Author

Toya, Yosuke, additional, Endo, Masaki, additional, Yamada, Shun, additional, Oizumi, Tomofumi, additional, Morishita, Toshifumi, additional, Akasaka, Risaburo, additional, Yanai, Shunichi, additional, Nakamura, Shotaro, additional, Eizuka, Makoto, additional, Uesugi, Noriyuki, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2021
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17. Resectability of underwater endoscopic mucosal resection for duodenal tumor: A single‐center, retrospective pilot study

Author

Toya, Yosuke, primary, Endo, Masaki, additional, Yamazato, Masanao, additional, Yamada, Shun, additional, Kumei, Tomo, additional, Hirai, Minami, additional, Eizuka, Makoto, additional, Morishita, Toshifumi, additional, Akasaka, Risaburo, additional, Yanai, Shunichi, additional, Uesugi, Noriyuki, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2021
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18. Protective effect of proton pump inhibitors and potassium competitive acid blockers against post-gastric endoscopic submucosal dissection bleeding: a single-center, propensity score-matched analysis

Author

Toya, Yosuke, primary, Endo, Masaki, additional, Sugai, Kyohei, additional, Yamada, Shun, additional, Oizumi, Tomofumi, additional, Morishita, Toshifumi, additional, Akasaka, Risaburo, additional, Yanai, Shunichi, additional, Nakamura, Shotaro, additional, Eizuka, Makoto, additional, Uesugi, Noriyuki, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2020
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20. Risk for lymph node metastasis in Epstein–Barr virus‐associated gastric carcinoma with submucosal invasion

Author

Tsuji, Yosuke, primary, Ushiku, Tetsuo, additional, Shinozaki, Tomohiro, additional, Yamashita, Hiroharu, additional, Seto, Yasuyuki, additional, Fukayama, Masashi, additional, Fujishiro, Mitsuhiro, additional, Oda, Ichiro, additional, Katai, Hitoshi, additional, Taniguchi, Hirokazu, additional, Hasatani, Kenkei, additional, Kaizaki, Yasuharu, additional, Oga, Atsunori, additional, Nishikawa, Jun, additional, Akasaka, Risaburo, additional, Endo, Masaki, additional, Sugai, Tamotsu, additional, Matsumoto, Takayuki, additional, and Koike, Kazuhiko, additional

Published
2020
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21. Tu1491 THE RISK FOR LYMPH NODE METASTASIS IN EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC CARCINOMA WITH SUBMUCOSAL INVASION IS QUITE LOW: A RETROSPECTIVE MULTICENTER STUDY

Author

Tsuji, Yosuke, primary, Ushiku, Tetsuo, additional, Yamashita, Hiroharu, additional, Seto, Yasuyuki, additional, Fukayama, Masashi, additional, Fujishiro, Mitsuhiro, additional, Oda, Ichiro, additional, Katai, Hitoshi, additional, Taniguchi, Hirokazu, additional, Hasatani, Kenkei, additional, Kaizaki, Yasuharu, additional, Oga, Atsunori, additional, Nishikawa, Jun, additional, Akasaka, Risaburo, additional, Endo, Masaki, additional, Sugai, Tamotsu, additional, Matsumoto, Takayuki, additional, and Koike, Kazuhiko, additional

Published
2020
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22. Diagnostic algorithm of magnifying endoscopy with crystal violet staining for non‐ampullary duodenal epithelial tumors

Author

Toya, Yosuke, primary, Endo, Masaki, additional, Oizumi, Tomofumi, additional, Akasaka, Risaburo, additional, Yanai, Shunichi, additional, Kawasaki, Keisuke, additional, Nakamura, Shotaro, additional, Eizuka, Makoto, additional, Fujita, Yasuko, additional, Uesugi, Noriyuki, additional, Ishida, Kazuyuki, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2020
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23. Microvascular density under magnifying narrow-band imaging endoscopy in colorectal epithelial neoplasms

Author

Gonai, Takahiro, primary, Kawasaki, Keisuke, additional, Nakamura, Shotaro, additional, Yanai, Shunichi, additional, Akasaka, Risaburo, additional, Sato, Kunihiko, additional, Toya, Yousuke, additional, Asakura, Kensuke, additional, Urushikubo, Jun, additional, Fujita, Yasuko, additional, Eizuka, Makoto, additional, Uesugi, Noriyuki, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2020
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26. Risk Factors for Post-gastric Endoscopic Submucosal Dissection Bleeding with a Special Emphasis on Anticoagulant Therapy

Author

Toya, Yosuke, primary, Endo, Masaki, additional, Oizumi, Tomofumi, additional, Akasaka, Risaburo, additional, Yanai, Shunichi, additional, Kawasaki, Keisuke, additional, Nakamura, Shotaro, additional, Eizuka, Makoto, additional, Fujita, Yasuko, additional, Uesugi, Noriyuki, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2019
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27. Clinicopathological and Molecular Findings of Differentiated-Type Minute Gastric Intramucosal Neoplasia

Author

Uesugi, Noriyuki, primary, Sugai, Tamotsu, additional, Sugimoto, Ryo, additional, Eizuka, Makoto, additional, Fujita, Yasuko, additional, Sato, Ayaka, additional, Osakabe, Mitsumasa, additional, Ishida, Kazuyuki, additional, Shiomi, Ei, additional, Toya, Yosuke, additional, Akasaka, Risaburo, additional, and Matsumoto, Takayuki, additional

Published
2019
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28. Risk for lymph node metastasis in Epstein–Barr virus‐associated gastric carcinoma with submucosal invasion.

Author

Tsuji, Yosuke, Ushiku, Tetsuo, Shinozaki, Tomohiro, Yamashita, Hiroharu, Seto, Yasuyuki, Fukayama, Masashi, Fujishiro, Mitsuhiro, Oda, Ichiro, Katai, Hitoshi, Taniguchi, Hirokazu, Hasatani, Kenkei, Kaizaki, Yasuharu, Oga, Atsunori, Nishikawa, Jun, Akasaka, Risaburo, Endo, Masaki, Sugai, Tamotsu, Matsumoto, Takayuki, and Koike, Kazuhiko

Subjects
EPSTEIN-Barr virus, LYMPHATIC metastasis, LOGISTIC regression analysis, STOMACH cancer, NON-coding RNA, ENDOSCOPIC surgery
Abstract

Objectives: Epstein–Barr virus‐associated gastric cancer (EBVGC) has been reported to be associated with a low risk for lymph node metastasis (LNM). However, the curative criteria for endoscopic submucosal dissection (ESD) for submucosal EBVGC (pT1b‐EBVGC) remain unclear. Our study aimed to investigate the risk factors for LNM in pT1b‐EBVGC. Methods: This was a retrospective multicenter study at five institutes in Japan. We reviewed medical records and extracted all pT1b‐EBVGC cases that met the following criteria: (i) histologically proven submucosal gastric cancer; (ii) surgical or endoscopic resection between January 2000 and December 2016; and (iii) presence of Epstein–Barr virus (EBV) in tumor cells verified by EBV‐encoded small RNA in situ hybridization (EBER‐ISH). The association between clinicopathological factors and LNM were assessed using multivariable logistic regression analysis. Results: A total of 185 pT1b‐EBVGC cases were included in the analysis. LNM was found in nine cases (4.9%). Multivariable logistic regression analysis demonstrated that lymphatic invasion (OR 9.1; 95% CI 2.1–46.1) and submucosal invasion ≥4000 μm (OR 9.2; 95% CI 1.3–110.3) were significant risk factors for LNM. When we focused on pT1b‐EBVGC without lymphatic invasion and with submucosal invasion <2000 μm, the rate of LNM was 0% (0/96, 95% CI 0–3.8%). Conclusions: Our findings indicated that lymphatic invasion and submucosal invasion ≥4000 μm were significant risk factors for LNM. ESD could be an appropriate option for pT1b‐EBVGC without lymphatic invasion and with submucosal invasion <2000 μm. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Protective effect of proton pump inhibitors and potassium competitive acid blockers against post-gastric endoscopic submucosal dissection bleeding: a single-center, propensity score-matched analysis.

Author

Toya, Yosuke, Endo, Masaki, Sugai, Kyohei, Yamada, Shun, Oizumi, Tomofumi, Morishita, Toshifumi, Akasaka, Risaburo, Yanai, Shunichi, Nakamura, Shotaro, Eizuka, Makoto, Uesugi, Noriyuki, Sugai, Tamotsu, and Matsumoto, Takayuki

Subjects
PROTON pump inhibitors, PROPENSITY score matching, HEMORRHAGE, POTASSIUM, H2 receptor antagonists, STOMACH cancer, POTASSIUM antagonists
Abstract

Both potassium-competitive acid blockers (P-CABs) and proton pump inhibitors (PPIs) are known to be protective against bleeding after gastric endoscopic dissection (ESD) for early gastric cancers. The aim was to compare the effect of PPI and P-CAB treatment against bleeding after gastric ESD. This was a single-center, retrospective analysis. Among 541 patients who underwent gastric ESD during the period from 2014 to 2019, we recruited subjects who were treated with PPIs (intravenous lansoprazole followed by oral esomeprazole) or a P-CAB before and after ESD. The incidence of post-ESD bleeding was compared between treatment groups. The risks associated with post-ESD bleeding were examined by univariate and multivariate analyses after propensity score-matching. The overall incidence of post-ESD bleeding was not significantly different between patients treated with PPIs (n = 362) and those treated with a P-CAB (n = 156) (3.0% vs 2.6%, respectively; p =.77). Even after propensity score matching (n = 153 in each group), the incidence was not significantly different between groups (2.6% vs 2.6%, respectively; p = 1.00). A multivariate analysis revealed that antithrombotic therapy (OR 4.85, 95% CI 1.14–20.57) was an independent factor associated with post-ESD bleeding. The incidence of post gastric ESD bleeding is not different between patients treated with PPI and patients treated with P-CAB. Antithrombotic therapy is an independent risk factor associated with post-ESD bleeding. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Immune checkpoint inhibitor‐induced diarrhea: Clinicopathological study of 11 patients.

Author

Yanai, Shunichi, Nakamura, Shotaro, Kawasaki, Keisuke, Toya, Yosuke, Akasaka, Risaburo, Oizumi, Tomofumi, Ishida, Kazuyuki, Sugai, Tamotsu, and Matsumoto, Takayuki

Subjects
PROGRAMMED cell death 1 receptors, IMMUNE checkpoint inhibitors, DIARRHEA, ULCERATIVE colitis, MEDICAL records
Abstract

We reviewed the records of patients with immune checkpoint inhibitor (ICI)‐induced diarrhea during 2015 to 2019. ICI included nivolumab and ipilimumab. There were 11 patients with ICI‐induced diarrhea aged 46–81 years (median, 63 years). On colonoscopy, four patients appeared normal, whereas loss of vascularity, erythema, granularity, erosions or ulcerations apparently mimicking ulcerative colitis were found in seven patients. Those seven patients had acute inflammation, cryptitis, crypt abscess and apoptosis, suggestive of ICI‐induced colitis. Five of the seven patients were treated with prednisolone, two of whom were resistant to prednisolone and required infliximab. In contrast, none of the four patients without ICI‐induced colitis required further treatment. Our observations suggest that diversity exists in the clinical, endoscopic and histological severity of patients with ICI‐induced diarrhea. Colonoscopy together with biopsy is inevitable for the diagnosis of ICI‐induced colitis, which requires intensive treatment. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Clinicopathological and Molecular Findings of Differentiated-Type Minute Gastric Intramucosal Neoplasia.

Author

Uesugi, Noriyuki, Sugai, Tamotsu, Sugimoto, Ryo, Eizuka, Makoto, Fujita, Yasuko, Sato, Ayaka, Osakabe, Mitsumasa, Ishida, Kazuyuki, Shiomi, Ei, Toya, Yosuke, Akasaka, Risaburo, and Matsumoto, Takayuki

Subjects
DNA methylation, SEX ratio, METHYLATION, DYSPLASIA, CARCINOGENESIS
Abstract

Background/Aims: To evaluate gastric early differentiate-type carcinogenesis, we attempted to identify clinicopathological and biological differences in differentiated-type minute intramucosal neoplasia (MIMN), which was defined as a tumor with a diameter of < 5 mm. Methods: We examined clinicopathological findings and biological factors, including TP53 overexpression, mucin phenotype, Ki-67-positive rate, MLH1, intranuclear accumulation of β-catenin, and DNA methylation status (low methylation epigenotype [LME], intermediate methylation epigenotype, and high methylation epigenotype [HME]) in MIMNs. In addition, non-MIMNs were also analyzed. In the present study, MIMN and non-MIMN were also examined based on low-grade dysplasia, high-grade dysplasia, and intramucosal cancer (IMC). Results: In clinicopathological findings, there were significant differences in sex ratios and tumor locations between MIMNs and non-MIMNs. Among the examined biological factors, no significant differences in the frequencies of biological factors were observed between the 2 intramucosal neoplasia types. However, the frequency of intranuclear accumulation of β-catenin was higher in non-MIMNs than in MIMNs. Finally, although the frequency of HME was significantly lower in MIMNs than in non-MIMNs, the opposite was observed for LME. Conclusions: The current finding suggested that DNA methylation and accumulation of β-catenin were closely associated with tumor development from MIMN to non-MIMN. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Long-term outcomes and prognostic factors with non-curative endoscopic submucosal dissection for gastric cancer in elderly patients aged ≥ 75 years

Author

Toya, Yosuke, primary, Endo, Masaki, additional, Nakamura, Shotaro, additional, Akasaka, Risaburo, additional, Yanai, Shunichi, additional, Kawasaki, Keisuke, additional, Koeda, Keisuke, additional, Eizuka, Makoto, additional, Fujita, Yasuko, additional, Uesugi, Noriyuki, additional, Ishida, Kazuyuki, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2018
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35. Clinicopathological Features and Magnifying Chromoendoscopic Findings of Non-Ampullary Duodenal Epithelial Tumors

Author

Toya, Yosuke, primary, Endo, Masaki, additional, Akasaka, Risaburo, additional, Urushikubo, Jun, additional, Gonai, Takahiro, additional, Asakura, Kensuke, additional, Yanai, Shunichi, additional, Kawasaki, Keisuke, additional, Eizuka, Makoto, additional, Uesugi, Noriyuki, additional, Nakamura, Shotaro, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2018
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36. Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms

Author

Kawasaki, Keisuke, primary, Eizuka, Makoto, additional, Nakamura, Shotaro, additional, Endo, Masaki, additional, Yanai, Shunichi, additional, Akasaka, Risaburo, additional, Toya, Yosuke, additional, Fujita, Yasuko, additional, Uesugi, Noriyuki, additional, Ishida, Kazuyuki, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2017
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38. A case of intravascular papillary endothelial hyperplasia of the stomach leading to a novel hypothesis for the pathogenesis

Author

Eizuka, Makoto, primary, Tsuchida, Kodai, additional, Sugimoto, Ryo, additional, Ishida, Kazuyuki, additional, Uesugi, Noriyuki, additional, Yanai, Syunichi, additional, Akasaka, Risaburo, additional, Toya, Yosuke, additional, Kawasaki, Keisuke, additional, Nakamura, Syotaro, additional, Matsumoto, Takayuki, additional, and Sugai, Tamotsu, additional

Published
2016
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40. Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel

Author

Sato, Kei A., primary, Hachiya, Tsuyoshi, additional, Iwaya, Takeshi, additional, Kume, Kohei, additional, Matsuo, Teppei, additional, Kawasaki, Keisuke, additional, Abiko, Yukito, additional, Akasaka, Risaburo, additional, Matsumoto, Takayuki, additional, Otsuka, Koki, additional, and Nishizuka, Satoshi S., additional

Published
2016
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41. Association between genomic alterations and metastatic behavior of colorectal cancer identified by array‐based comparative genomic hybridization

Author

Sawada, Takeshi, primary, Yamamoto, Eiichiro, additional, Suzuki, Hiromu, additional, Nojima, Masanori, additional, Maruyama, Reo, additional, Shioi, Yoshihiro, additional, Akasaka, Risaburo, additional, Kamimae, Seiko, additional, Harada, Taku, additional, Ashida, Masami, additional, Kai, Masahiro, additional, Adachi, Yasushi, additional, Yamamoto, Hiroyuki, additional, Imai, Kohzoh, additional, Toyota, Minoru, additional, Itoh, Fumio, additional, and Sugai, Tamotsu, additional

Published
2012
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42. Colonic Mucosa-Associated Lymphoid Tissue Lymphoma

Author

Akasaka, Risaburo, primary, Chiba, Toshimi, additional, Dutta, Amit K., additional, Toya, Yosuke, additional, Mizutani, Tomomi, additional, Shozushima, Tatsuyori, additional, Abe, Keinosuke, additional, Kamei, Masato, additional, Kasugai, Satoshi, additional, Shibata, Sho, additional, Abiko, Yukito, additional, Yokoyama, Naoki, additional, Oana, Shuhei, additional, Hirota, Shigeru, additional, Endo, Masaki, additional, Uesugi, Noriyuki, additional, Sugai, Tamotsu, additional, and Suzuki, Kazuyuki, additional

Published
2012
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43. Unusual Manifestation of Gastric Helicobacter pylori Infection

Author

Dutta, Amit K., primary, Chiba, Toshimi, additional, Toya, Yosuke, additional, Mizutani, Tomomi, additional, Kasugai, Satoshi, additional, Matsuda, Nozomi, additional, Shibata, Sho, additional, Abiko, Yukito, additional, Akasaka, Risaburo, additional, Yokoyama, Naoki, additional, Oana, Shuhei, additional, Hirota, Shigeru, additional, Endo, Masaki, additional, Uesugi, Noriyuki, additional, Sugai, Tamotsu, additional, and Suzuki, Kazuyuki, additional

Published
2012
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47. Characterization of Follicular Lymphoma in the Small Intestine Using Double-Balloon Endoscopy

Author

Chowdhury, Manzurul, primary, Endo, Masaki, additional, Chiba, Toshimi, additional, Kudara, Norihiko, additional, Oana, Shuhei, additional, Sato, Kunihiko, additional, Akasaka, Risaburo, additional, Tomita, Kazumitsu, additional, Fujiwara, Saori, additional, Mizutani, Tomomi, additional, Sugai, Tamotsu, additional, Takikawa, Yasuhiro, additional, and Suzuki, Kazuyuki, additional

Published
2009
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49. Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa.

Author

Sugai T, Habano W, Jiao YF, Toyota M, Suzuki H, Tsukahara M, Koizuka H, Akasaka R, Koeda K, Wakabayashi G, and Suzuki K

Subjects
Adult, Aged, Aged, 80 and over, Alleles, Allelic Imbalance, Disease Progression, Female, Humans, Male, Microsatellite Repeats genetics, Middle Aged, Adenocarcinoma genetics, Adenocarcinoma pathology, Gastric Mucosa pathology, Metaplasia genetics, Metaplasia pathology, Stomach Neoplasms genetics, Stomach Neoplasms pathology
Abstract

The biological properties and underlying genetics of gastric cancer and gastric intestinal metaplasia evolve with neoplastic progression from the genetics of the original gland cell. PCR assay with crypt isolation was used in tumors from 20 patients to examine microsatellite alterations (allelic imbalance at 17p, 5q, 18q, 3p, 4p, and 9p, and microsatellite instability) in glands from each tumor and from intestinal metaplastic lesions. Tumor specimens were processed as either pooled-gland samples or single-gland samples. Pooled gland sample was composed of 10-20 tumor glands, intestinal metaplastic glands, or nonmetaplastic glands. Single gland sample was 10 tumor glands from tumor and single gland sample was 5 gastric intestinal metaplastic and 5 nonmetaplastic glands from its surrounding metaplastic mucosa. Multiple genetic alterations were found in individual tumor glands, with various subclonal expansions seen within the same tumor. Although microsatellite instability was found in 2 of 20 tumor single-gland samples, none was detected in metaplastic single-gland samples. Most cancers appear to have a heterogeneous composition. On the other hand, microsatellite alterations were also detected within the nonmetaplastic as well as intestinal metaplastic single-gland samples. In conclusion, the present data on tumor and corresponding intestinal metaplastic and nonmetaplastic glands suggest that genetic alterations already occur within the surrounding of the noncancerous mucosa.

Published
2010

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