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3. The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology

Author

Loupy, A, Haas, M, Solez, K, Racusen, L, Glotz, D, Seron, D, Nankivell, BJ, Colvin, RB, Afrouzian, M, Akalin, E, Alachkar, N, Bagnasco, S, Becker, JU, Cornell, L, Drachenberg, C, Dragun, D, de Kort, H, Gibson, IW, Kraus, ES, Lefaucheur, C, Legendre, C, Liapis, H, Muthukumar, T, Nickeleit, V, Orandi, B, Park, W, Rabant, M, Randhawa, P, Reed, EF, Roufosse, C, Seshan, SV, Sis, B, Singh, HK, Schinstock, C, Tambur, A, Zeevi, A, and Mengel, M

Subjects
Organ Transplantation, Clinical Research, Transplantation, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Renal and urogenital, Arteritis, Complement C4b, Graft Rejection, Humans, Isoantibodies, Kidney Transplantation, Peptide Fragments, Research Report, clinical research, practice, translational research, science, kidney transplantation, nephrology, pathology, histopathology, organ transplantation in general, rejection, rejection: antibody-mediated, rejection: subclinical, rejection: T cell mediated, clinical research/practice, kidney transplantation/nephrology, pathology/histopathology, translational research/science, Medical and Health Sciences, Surgery
Abstract

The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d-negative antibody-mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor-specific antibody tests (anti-HLA and non-HLA) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection requires further consensus agreement and validation in biopsies. Newly introduced concepts include the i-IFTA score, comprising inflammation within areas of fibrosis and atrophy and acceptance of transplant arteriolopathy within the descriptions of chronic active T cell-mediated rejection (TCMR) or chronic ABMR. The pattern of mixed TCMR and ABMR was increasingly recognized. This report also includes improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification. The goal of the Banff process is ongoing integration of advances in histologic, serologic, and molecular diagnostic techniques to produce a consensus-based reporting system that offers precise composite scores, accurate routine diagnostics, and applicability to next-generation clinical trials.

Published
2017

5. On the principles of B-smooth discontinuous flows

Author

Akalin, E. and Akhmet, M. U.

Subjects
Mathematics - Dynamical Systems, 37-99, 34A37
Abstract

In this paper, we define B-smooth discontinuous dynamical systems which can be used as models of various processes in mechanics, electronics, biology and medicine. We find sufficient conditions to guarantee the existence of such systems. These conditions are easy to verify. Appropriate examples are constructed., Comment: This paper has been withdrawn by the second author, since precised results of the paper are published in the book: Principles of discontinuous dynamical systems, Springer, 2010

Published
2004

13. The Age-Dependent Role of Th22, Tc22, and Tc17 Cells in the Severity of Pneumonia in COVID-19 Immunopathogenesis

Author

Cagan, Eren, primary, Tezcan, Gulcin, additional, Simsek, Abdurrahman, additional, Kizmaz, Muhammed Ali, additional, Dombaz, Fatma, additional, Asan, Ali, additional, Demir, H. Ibrahim, additional, Bal, Haldun, additional, Yoyen Ermis, Digdem, additional, Gorek Dilektasli, Aslı, additional, Kazak, Esra, additional, Akalin, E. Halis, additional, Oral, H. Barbaros, additional, and Budak, Ferah, additional

Published
2022
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15. Assessment of CD39 expression in regulatory T‐cell subsets by disease severity in adult and juvenile COVID‐19 cases

Author

Simsek, Abdurrahman, primary, Kizmaz, Muhammed A., additional, Cagan, Eren, additional, Dombaz, Fatma, additional, Tezcan, Gulcin, additional, Asan, Ali, additional, Demir, H. Ibrahim, additional, Bal, S. Haldun, additional, Ermis, Digdem Y., additional, Dilektaslı, Aslı G., additional, Kazak, Esra, additional, Akalin, E. Halis, additional, Oral, H. Barbaros, additional, and Budak, Ferah, additional

Published
2022
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18. Resorption of a Sequestrated Cervical Disc

Author

Kocyigit A, Manisali M, and Akalin E

Subjects
Conservative treatment, Cervical disc sequestration, Magnetic resonance imaging, Medicine
Abstract

In literature cervical disc extrusions are considered bymost neurosurgeons a definitive indication for surgery.This approach may stem from a fear of disc fragmentmigration with neurological deterioration. We report arare case of cervical disc sequestration with a seldomprognosis which resolved spontaneously in a 2 monthfollow up on magnetic resonance imaging, emphasizingthe efficacy and applicability of conservative treatmentin cervical disc herniations. Even with the basicconservative treatment methods we observed theprominent decrease in symptoms and spontaneous totalresorption of the sequestrated fragment. Conservativetreatment in sequestrated cervical discs with noneurological deficit can be an alternative therapeuticapproach with the guidence of MRI.

Published
2010

29. Banff 2019 Meeting Report: Molecular diagnostics in solid organ transplantation–Consensus for the Banff Human Organ Transplant (B-HOT) gene panel and open source multicenter validation

Author

Mengel, M, Loupy, A., Haas, M. (Mark), Roufosse, C., Naesens, M, Akalin, E., Clahsen-van Groningen, M.C. (Marian), Dagobert, J., Demetris, A.J., Duong van Huyen, J.P., Gueguen, J., Issa, F., Robin, B., Rosales, I., von der Thüsen, J.H., Sanchez-Fueyo, A. (Albert), Smith, R.N., Wood, K., Adam, B., Colvin, R.B., Mengel, M, Loupy, A., Haas, M. (Mark), Roufosse, C., Naesens, M, Akalin, E., Clahsen-van Groningen, M.C. (Marian), Dagobert, J., Demetris, A.J., Duong van Huyen, J.P., Gueguen, J., Issa, F., Robin, B., Rosales, I., von der Thüsen, J.H., Sanchez-Fueyo, A. (Albert), Smith, R.N., Wood, K., Adam, B., and Colvin, R.B.

Abstract

This meeting report from the XV Banff conference describes the creation of a multiorgan transplant gene panel by the Banff Molecular Diagnostics Working Group (MDWG). This Banff Human Organ Transplant (B-HOT) panel is the culmination of previous work by the MDWG to identify a broadly useful gene panel based on whole transcriptome technology. A data-driven process distilled a gene list from peer-reviewed comprehensive microarray studies that discovered and validated their use in kidney, liver, heart, and lung transplant biopsies. These were supplemented by genes that define relevant cellular pathways and cell types plus 12 reference genes used for normalization. The 770 gene B-HOT panel includes the most pertinent genes related to rejection, tolerance, viral infections, and innate and adaptive immune responses. This commercially available panel uses the NanoString platform, which can quantitate transcripts from formalin-fixed paraffin-embedded samples. The B-HOT panel will facilitate multicenter collaborative clinical research using archival samples and permit the development of an open source large database of standardized analyses, thereby expediting clinical validation studies. The MDWG believes that a pathogenesis and pathway based molecular approach will be valuable for investigators and promote therapeutic decision-making and clinical trials.

Published
2020
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30. The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell– and antibody-mediated rejection

Author

Loupy, A. (Alexandre), Haas, M. (Mark), Roufosse, C. (Candice), Naesens, L., Adam, B. (Benjamin), Afrouzian, M. (Marjan), Akalin, E. (Enver), Alachkar, N. (Nada), Bagnasco, S. (Serena), Becker, J.U. (Jan U.), Cornell, L.D. (Lynn D.), Clahsen-van Groningen, M.C. (Marian), Demetris, A.J. (Anthony J.), Dragun, D. (Duska), Duong van Huyen, J.-P. (Jean-Paul), Farris, A.B. (Alton), Fogo, A.B. (Agnes), Gibson, I.W. (Ian), Glotz, D. (Denis), Gueguen, J. (Juliette), Kikic, Z. (Zeljko), Kozakowski, N. (Nicolas), Kraus, E. (Edward), Lefaucheur, C. (Carmen), Liapis, H. (Helen), Mannon, R.B. (Roslyn), Montgomery, R.A. (Robert A.), Nankivell, B.J. (Brian J.), Nickeleit, V. (Volker), Nickerson, P. (Peter), Rabant, M. (Marion), Racusen, L. (Lorraine), Randhawa, P. (Parmjeet), Robin, B. (Blaise), Rosales, I.A. (Ivy A.), Sapir-Pichhadze, R. (Ruth), Schinstock, C.A. (Carrie A.), Seron, D. (Daniel), Singh, H.K. (Harsharan K.), Smith, R.N. (Rex N.), Stegall, M.D. (Mark D.), Zeevi, A. (Adriana), Solez, K. (Kim), Colvin, R.B. (Robert B.), Mengel, M. (Michael), Loupy, A. (Alexandre), Haas, M. (Mark), Roufosse, C. (Candice), Naesens, L., Adam, B. (Benjamin), Afrouzian, M. (Marjan), Akalin, E. (Enver), Alachkar, N. (Nada), Bagnasco, S. (Serena), Becker, J.U. (Jan U.), Cornell, L.D. (Lynn D.), Clahsen-van Groningen, M.C. (Marian), Demetris, A.J. (Anthony J.), Dragun, D. (Duska), Duong van Huyen, J.-P. (Jean-Paul), Farris, A.B. (Alton), Fogo, A.B. (Agnes), Gibson, I.W. (Ian), Glotz, D. (Denis), Gueguen, J. (Juliette), Kikic, Z. (Zeljko), Kozakowski, N. (Nicolas), Kraus, E. (Edward), Lefaucheur, C. (Carmen), Liapis, H. (Helen), Mannon, R.B. (Roslyn), Montgomery, R.A. (Robert A.), Nankivell, B.J. (Brian J.), Nickeleit, V. (Volker), Nickerson, P. (Peter), Rabant, M. (Marion), Racusen, L. (Lorraine), Randhawa, P. (Parmjeet), Robin, B. (Blaise), Rosales, I.A. (Ivy A.), Sapir-Pichhadze, R. (Ruth), Schinstock, C.A. (Carrie A.), Seron, D. (Daniel), Singh, H.K. (Harsharan K.), Smith, R.N. (Rex N.), Stegall, M.D. (Mark D.), Zeevi, A. (Adriana), Solez, K. (Kim), Colvin, R.B. (Robert B.), and Mengel, M. (Michael)

Abstract

The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. This report on kidney transplant pathology details clarifications and refinements to the criteria for chronic active (CA) T cell–mediated rejection (TCMR), borderline, and antibody-mediated rejection (ABMR). The main focus of kidney sessions was on how to address biopsies meeting criteria for CA TCMR plus borderline or acute TCMR. Recent studies on the clinical impact of borderline infiltrates were also presented to clarify whether the threshold for interstitial inflammation in diagnosis of borderline should be i0 or i1. Sessions on ABMR focused on biopsies showing microvascular inflammation in the absence of C4d staining or detectable donor-specific antibodies; the potential value of molecular diagnostics in such cases and recommendations for use of the latter in the setting of solid organ transplantation are presented in the accompanying meeting report. Finally, several speakers discussed the capabilities of artificial intelligence and the potential for use of machine learning algorithms in diagnosis and personalized therapeutics in solid organ transplantation.

Published
2020
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31. The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell– and antibody-mediated rejection

Author

Loupy, A, de Haas, M, Roufosse, C, Naesens, M, Adam, B, Afrouzian, M, Akalin, E, Alachkar, N, Bagnasco, S, Becker, JU, Cornell, LD, Groningen, Marian, Demetris, AJ, Dragun, D, Duong van Huyen, JP, Farris, AB, Fogo, AB, Gibson, IW, Glotz, D, Gueguen, J, Kikic, Z, Kozakowski, N, Kraus, E, Lefaucheur, C, Liapis, H, Mannon, RB, Montgomery, RA, Nankivell, BJ, Nickeleit, V, Nickerson, P, Rabant, M, Racusen, L, Randhawa, P, Robin, B, Rosales, IA, Sapir-Pichhadze, R, Schinstock, CA, Seron, D, Singh, HK, Smith, RN, Stegall, MD, Zeevi, A, Solez, K, Colvin, RB, Mengel, M, Loupy, A, de Haas, M, Roufosse, C, Naesens, M, Adam, B, Afrouzian, M, Akalin, E, Alachkar, N, Bagnasco, S, Becker, JU, Cornell, LD, Groningen, Marian, Demetris, AJ, Dragun, D, Duong van Huyen, JP, Farris, AB, Fogo, AB, Gibson, IW, Glotz, D, Gueguen, J, Kikic, Z, Kozakowski, N, Kraus, E, Lefaucheur, C, Liapis, H, Mannon, RB, Montgomery, RA, Nankivell, BJ, Nickeleit, V, Nickerson, P, Rabant, M, Racusen, L, Randhawa, P, Robin, B, Rosales, IA, Sapir-Pichhadze, R, Schinstock, CA, Seron, D, Singh, HK, Smith, RN, Stegall, MD, Zeevi, A, Solez, K, Colvin, RB, and Mengel, M

Published
2020

48. Influence of chemical process on structural and optical properties of as-grown and thermal annealed GaAsBi alloys

Author

Dönmez, Ömer, Kara, K., Erol, Ayse, AKALIN, E., Makhloufi, Hajer, Arnoult, Alexandre, Fontaine, Chantal, Université d'Istanbul, Équipe Photonique (LAAS-PHOTO), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Service Techniques et Équipements Appliqués à la Microélectronique (LAAS-TEAM), Prof. Kirstin Volz, Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), and Université Fédérale Toulouse Midi-Pyrénées

Subjects
[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience

Published
2017

49. Effects of DNA methylation on progression to interstitial fibrosis and tubular atrophy in renal allograft biopsies: a multi-omics approach

Author

Bontha, S V, Maluf, D G, Archer, K J, Dumur, C I, Dozmorov, M G, King, A L, Akalin, E, Mueller, T F, Gallon, L, Mas, V R, University of Zurich, and Mas, V R

Subjects
2747 Transplantation, fibrosis, 2723 Immunology and Allergy, genomics, graft survival, 2736 Pharmacology (medical), molecular biology, 610 Medicine & health, 10035 Clinic for Nephrology, translational research / science, kidney transplantation / nephrology
Published
2017

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