822 results on '"Akaishi P"'
Search Results
2. Investigation on luminescence photoswitching stability in diarylethene-perovskite quantum dot hybrids
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Mokhtar, Ashkan, Akaishi, Yuji, Tokudome, Keisuke, Kim, Sunnam, Kosumi, Daisuke, Kida, Tetsuya, and Fukaminato, Tsuyoshi
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- 2024
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3. Oral alkalinizing supplementation suppressed intrarenal reactive oxidative stress in mild-stage chronic kidney disease: a randomized cohort study
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Abe, Michiaki, Yamaguchi, Takuhiro, Koshiba, Seizo, Takayama, Shin, Nakai, Toshiki, Nishioka, Koichiro, Yamasaki, Satomi, Kawaguchi, Kazuhiko, Umeyama, Masanori, Masaura, Atsuko, Ishizawa, Kota, Arita, Ryutaro, Kanno, Takeshi, Akaishi, Tetsuya, Miyazaki, Mariko, Abe, Takaaki, Tanaka, Tetsuhiro, and Ishii, Tadashi
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- 2024
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4. Cost-Effectiveness Analysis of Maternal Respiratory Syncytial Virus Vaccine in Protecting Infants from RSV Infection in Japan
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Ishiwada, Naruhiko, Akaishi, Rina, Kobayashi, Yasuhiro, Togo, Kanae, Yonemoto, Naohiro, Matsuo, Moe, Kaneko, Shinnosuke, Law, Amy W., and Kamei, Kazumasa
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- 2024
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5. Association between endometriosis and perinatal complications: a case-control study
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Uchida, Sonoka, Fukuhara, Rie, Yokoyama, Machi, Akaishi, Asami, Iino, Kaori, Yokota, Megumi, and Yokoyama, Yoshihito
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- 2024
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6. Mixed-methods study of medical students’ attitudes toward peer physical examinations in Japan
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Suzuki, Emily, Nawa, Nobutoshi, Okada, Eriko, Akaishi, Yu, Kashimada, Ayako, Numasawa, Mitsuyuki, Yamaguchi, Kumiko, Takada, Kazuki, and Yamawaki, Masanaga
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- 2024
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7. Exploring digital use, happiness, and loneliness in Japan with the experience sampling method
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Yijun Chen, Xiaochu Zhang, and Rei Akaishi
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Therapeutics. Psychotherapy ,RC475-489 - Abstract
Abstract Smartphones have become an integral part of modern life, raising concerns about their impact on mental health, especially among young people. However, previous studies yielded inconsistent results, possibly due to neglecting the possibility of interactions between offline and online communications. To explore potential interactions among different communication modes (online vs. offline) and communication types (private vs. public), we adopted the experience sampling method to track 418 Japanese individuals over 21 days and analyzed the data using multilevel models and psychometric network models. The findings revealed that digital use has only small direct effects on happiness and loneliness, especially through public (one-to-many) online communication. The increased digital use reduced offline communication time, indirectly influencing loneliness to a large degree. Overall, this study highlights the indirect effects of decreased face-to-face communication and the significant role of one-to-many online communication, which may explain a part of the diverse findings on this issue.
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- 2024
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8. Effect of Long-Acting Diquafosol Sodium on Astigmatism Measurement Repeatability in Preoperative Cataract Cases with Dry Eyes: A Multicenter Prospective Study
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Teshigawara, Takeshi, Akaishi, Miki, Mizuki, Yuki, Takeuchi, Masaki, Hata, Seiichiro, Meguro, Akira, and Mizuki, Nobuhisa
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- 2024
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9. Prenatal hypertension as the risk of eclampsia, HELLP syndrome, and critical obstetric hemorrhage
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Akaishi, Tetsuya, Tarasawa, Kunio, Hamada, Hirotaka, Iwama, Noriyuki, Tomita, Hasumi, Akaishi, Miho, Fushimi, Kiyohide, Fujimori, Kenji, Yaegashi, Nobuo, and Saito, Masatoshi
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- 2024
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10. Association between endometriosis and perinatal complications: a case-control study
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Sonoka Uchida, Rie Fukuhara, Machi Yokoyama, Asami Akaishi, Kaori Iino, Megumi Yokota, and Yoshihito Yokoyama
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Endometriosis ,Placenta previa ,Perinatal outcomes ,Perinatal complications ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Recently, a history of endometriosis has been reported to be associated with several perinatal complications. However, it is unknown whether pre-pregnancy treatment for endometriosis reduces perinatal complications. In this study, we aimed to clarify the association between endometriosis and perinatal complications and investigate whether there is a significant difference in the incidence of placenta previa depending on the degree of surgical completion of endometriosis before pregnancy. Methods This case-control study included 2781 deliveries at the Hirosaki University Hospital between January 2008 and December 2019. The deliveries were divided into a case group with a history of endometriosis (n = 133) and a control group without endometriosis (n = 2648). Perinatal outcomes and complications were compared between the case and control groups using a t-test and Fisher’s exact test. Multiple logistic regression models were used to identify the risk factors for placenta previa. Additionally, we examined whether the degree of surgical completion of endometriosis before pregnancy was associated with the risk of placenta previa. Results Patients with a history of endometriosis had a significantly higher risk of placenta previa (crude odds ratio, 2.66; 95% confidence interval, 1.37‒4.83). Multiple logistic regression analysis showed that a history of endometriosis was a significant risk factor for placenta previa (adjusted odds ratio, 2.30; 95% confidence interval, 1.22‒4.32). In addition, among patients with revised American Society for Reproductive Medicine stage III–IV endometriosis, the incidence of placenta previa was significantly lower in patients who underwent complete surgery (3/51 patients, 5.9%) than in those who did not (3/9 patients, 33.3%) (p = 0.038). Conclusions A history of endometriosis is an independent risk factor for placenta previa. Given the limitations of this study, further research is needed to determine the impact of endometriosis surgery on perinatal complications.
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- 2024
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11. Precise lifetime measurement of $^4_\Lambda$H hypernucleus using in-flight $^4$He$(K^-, \pi^0)^4_\Lambda$H reaction
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Akaishi, T., Asano, H., Chen, X., Clozza, A., Curceanu, C., Del Grande, R., Guaraldo, C., Han, C., Hashimoto, T., Iliescu, M., Inoue, K., Ishimoto, S., Itahashi, K., Iwasaki, M., Ma, Y., Miliucci, M., Murayama, R., Noumi, H., Ohnishi, H., Okada, S., Outa, H., Piscicchia, K., Sakaguchi, A., Sakuma, F., Sato, M., Scordo, A., Shirotori, K., Sirghi, D., Sirghi, F., Suzuki, S., Tanida, K., Toda, T., Tokuda, M., Yamaga, T., Yuan, X., Zhang, P., Zhang, Y., and Zhang, H.
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Nuclear Experiment - Abstract
We present a new measurement of the $^4_\Lambda$H hypernuclear lifetime using in-flight $K^-$ + $^4$He $\rightarrow$ $^4_\Lambda$H + $\pi^0$ reaction at the J-PARC hadron facility. We demonstrate, for the first time, the effective selection of the hypernuclear bound state using only the $\gamma$-ray energy decayed from $\pi^0$. This opens the possibility for a systematic study of isospin partner hypernuclei through comparison with data from ($K^-$, $\pi^-$) reaction. As the first application of this method, our result for the $^4_\Lambda$H lifetime, $\tau(^4_\Lambda \mathrm{H}) = 206 \pm 8 (\mathrm{stat.}) \pm 12 (\mathrm{syst.})\ \mathrm{ps}$, is one of the most precise measurements to date. We are also preparing to measure the lifetime of the hypertriton ($^3_\Lambda$H) using the same setup in the near future.
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- 2023
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12. Cost-Effectiveness Analysis of Maternal Respiratory Syncytial Virus Vaccine in Protecting Infants from RSV Infection in Japan
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Naruhiko Ishiwada, Rina Akaishi, Yasuhiro Kobayashi, Kanae Togo, Naohiro Yonemoto, Moe Matsuo, Shinnosuke Kaneko, Amy W. Law, and Kazumasa Kamei
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Cost-effectiveness analysis ,Japan ,Palivizumab ,Respiratory syncytial virus ,RSVpreF ,Vaccination ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Introduction Respiratory syncytial virus (RSV) is one of the major causes of respiratory tract infections among children. Until recently, the monoclonal antibody palivizumab was the only RSV prophylaxis available in Japan. In 2024, the bivalent RSV prefusion F protein-based (RSVpreF) vaccine was approved for the prevention of RSV infection in infants by active immunization of pregnant women. In this study, we assessed the cost-effectiveness of a combined strategy of RSVpreF vaccine and palivizumab in Japanese setting. Methods Using a Markov model, we evaluated prevented cases and deaths of medically attended RSV infections from birth to age 11 months for each of the three healthcare settings: inpatient (hospitalization), emergency department visits, and outpatient visits. Incremental cost-effectiveness ratios (ICERs) were calculated from economic outcomes (intervention costs, medication costs, and productivity losses) and quality-adjusted life years (QALYs). Further, we calculated the maximum price of RSVpreF vaccine within which the program would be cost-effective. Results In comparison with the current prophylaxis (palivizumab alone), a combined prophylaxis of year-round RSVpreF vaccination of pregnant women and palivizumab prescription for premature infants born in
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- 2024
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13. Mixed-methods study of medical students’ attitudes toward peer physical examinations in Japan
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Emily Suzuki, Nobutoshi Nawa, Eriko Okada, Yu Akaishi, Ayako Kashimada, Mitsuyuki Numasawa, Kumiko Yamaguchi, Kazuki Takada, and Masanaga Yamawaki
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Peer physical examination ,Human rights protection, medical students in Japan ,Incidental findings ,PPE policy, autonomy, privacy ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background Most Japanese medical schools likely continue to rely on peer physical examination (PPE) as a tool to for teaching physical examination skills to students. However, the attitudes of medical students in Japan toward PPEs have not be identified. Therefore, we evaluated students’ attitudes toward PPE in a Japanese medical school as a preparation for developing a PPE policy tailored to the context of Japanese culture. Methods We conducted a mixed-methods study with an explanatory sequential approach, in which qualitative data were used to interpret the quantitative findings. Surveys and interviews were conducted with medical students and junior residents at a Japanese university. A total of 63 medical students and 50 junior residents responded to the questionnaire. We interviewed 16 participants to reach theoretical saturation and investigated the attitudes of medical students toward PPE and the themes emerging from the interview data, providing detailed descriptions of the quantitative findings. Results Female participants were significantly more likely than male participants to report varying degrees of resistance to being a model patient during PPE (male: 59.7%, female: 87%, p
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- 2024
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14. Effect of Long-Acting Diquafosol Sodium on Astigmatism Measurement Repeatability in Preoperative Cataract Cases with Dry Eyes: A Multicenter Prospective Study
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Takeshi Teshigawara, Miki Akaishi, Yuki Mizuki, Masaki Takeuchi, Seiichiro Hata, Akira Meguro, and Nobuhisa Mizuki
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Cataract surgery ,Corneal astigmatism ,Dry eye ,Diquafosol sodium ,Long-acting ,Repeatability ,Ophthalmology ,RE1-994 - Abstract
Abstract Introduction Dry eye can compromise corneal astigmatism measurement repeatability during preoperative cataract surgery examination. No previous studies have analyzed the effectiveness of long-acting 3% diquafosol sodium (LA-DQS) on astigmatism measurement repeatability. This research assessed the effect of LA-DQS on astigmatism measurement repeatability in preoperative patients with cataract and short tear break-up time (TBUT) type dry eyes in both eyes of the same patient. Correlations between repeatability and TBUT, corneal high-order aberrations (HOAs), and corneal astigmatism magnitude were also analyzed. Methods In total, 122 eyes (61 patients) with short TBUT-type dry eye were enrolled. Preoperatively, only one eye of all patients was treated with LA-DQS for 4 weeks. TBUT and corneal HOAs were checked using CASIA 2 before and 4 weeks post-treatment. The cylindrical power and meridian of astigmatism were measured at 3- and 4-week post-treatment using IOLMaster 700. Power vectors J0 and J45 were used for astigmatism calculations. Repeatability of astigmatism measurements was assessed as the within-subject standard deviation (Sw). The relative effects of TBUT and HOAs on J0 Sw and J45 Sw were also analyzed. Comparative changes in these variables were evaluated between treated and non-treated eyes, with additional analysis of their correlations. Results Treated eyes exhibited significant improvements in TBUT, HOAs, and post-treatment measurements of J0 Sw and J45 Sw at 3 and 4 weeks. In non-treated eyes, J0 Sw and J45 Sw showed significant correlation with TBUT and corneal HOAs. HOAs showed stronger relative associations with J0 Sw and J45 Sw than TBUT. In non-treated eyes, no significant correlation was found between cylindrical power and astigmatism measurement repeatability. Conclusions In short TBUT-type dry eye, preoperative treatment with LA-DQS significantly improved astigmatism measurement repeatability. This may improve the precision of intraocular lens (IOL) power calculations regardless of the magnitude of corneal astigmatism, especially when toric IOLs are used.
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- 2024
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15. Pole position of $\Lambda(1405)$ measured in $d(K^-,n)\pi\Sigma$ reactions
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Collaboration, J-PARC E31, Aikawa, S., Ajimura, S., Akaishi, T., Asano, H., Beer, G., Berucci, C., Bragadireanu, M., Buehler, P., Busso, L., Cargnelli, M., Choi, S., Curceanu, C., Enomoto, S., Fujioka, H., Fujiwara, Y., Fukuda, T., Guaraldo, C., Hashimoto, T., Hayano, R. S., Hiraiwa, T., Iio, M., Iliescu, M., Inoue, K., Ishiguro, Y., Ishimoto, S., Ishikawa, T., Itahashi, K., Iwai, M., Iwasaki, M., Kanno, K., Kato, K., Kato, Y., Kawasaki, S., Kienle, P., Komatsu, Y., Kou, H., Ma, Y., Marton, J., Matsuda, Y., Mizoi, Y., Morra, O., Murayama, R., Nagae, T., Noumi, H., Ohnishi, H., Okada, S., Omar, Z., Outa, H., Piscicchia, K., Sada, Y., Sakaguchi, A., Sakuma, F., Sato, M., Scordo, A., Sekimoto, M., Shi, H., Shirotori, K., Sirghi, D., Sirghi, F., Suzuki, K., Suzuki, S., Suzuki, T., Tanida, K., Tatsuno, H., Tokiyasu, A. O., Tokuda, M., Tomono, D., Toyoda, A., Tsukada, K., Vazquez-Doce, O., Widmann, E., Yamaga, T., Yamazaki, T., Yim, H., Zhang, Q., and Zmeskal, J.
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Nuclear Experiment - Abstract
We measured a set of $\pi^\pm\Sigma^\mp$, $\pi^0\Sigma^0$, and $\pi^-\Sigma^0$ invariant mass spectra below and above the $\bar{K}N$ mass threshold in $K^-$-induced reactions on deuteron. We deduced the $S$-wave $\bar{K}N\rightarrow\pi\Sigma$ and $\bar{K}N\rightarrow\bar{K}N$ scattering amplitudes in the isospin 0 channel in the framework of a $\bar{K}N$ and $\pi\Sigma$ coupled channel. We find that a resonance pole corresponding to $\Lambda(1405)$ is located at 1417.7$^{+6.0}_{-7.4}$(fitting errors)$^{+1.1}_{-1.0}$(systematic errors) + $[-26.1^{+6.0}_{-7.9}$(fitting errors)$^{+1.7}_{-2.0}$(systematic errors)]$i$ MeV/$c^2$, closer to the $\bar{K}N$ mass threshold than the value determined by the Particle Data Group., Comment: 8 pages, 5 figures
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- 2022
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16. Investigation of the Optimal Age in Months for Initiation of Conservative Treatment for Congenital Auricular Deformities
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Asuka Takada, MD, Hiroaki Kuwahara, MD, PhD, Takuya Tsuge, MD, PhD, Rei Ogawa, MD, PhD, FACS, and Satoshi Akaishi, MD, PhD
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Surgery ,RD1-811 - Abstract
Background:. The effectiveness of conservative treatment for congenital auricular deformities depends primarily on the plasticity of the auricular cartilage. However, the effect remains uncertain due to various confounding factors such as differences in the characteristics of the deformity and timing of treatment initiation. In this study, we investigated the optimal timing for initiation of conservative treatment. Methods:. We investigated the age at treatment initiation and surgical avoidance rate among 158 children with congenital auricular deformities who were treated with corrective devices at our hospital. In addition, we conducted and analyzed questionnaires containing items assessing treatment satisfaction and characteristics. Results:. Surgical avoidance rates decreased markedly among those starting treatment after 5 months of age, and satisfaction was significantly higher in the surgical avoidance group. Multivariate analysis showed that the only factor affecting the treatment effect was the age at treatment initiation. Conclusions:. This study suggests that the initiation of conservative treatment with corrective devices within 5 months of age for congenital auricular deformities may lead to avoidance of surgery and increased satisfaction. However, we should not judge the indication for conservative treatment solely based on age in months. Bearing in mind the effectiveness of initiating treatment within the first 5 months of age, we should initiate treatment at the earliest appropriate age with consideration of the individual patient's type and severity of deformity and cartilage elasticity.
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- 2024
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17. Algorithm-based Management of Infantile Hemangiomas: Reducing Sequelae and Surgical Interventions
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Akana Nishimoto, MD, PhD, Rei Ogawa, MD, PhD, and Satoshi Akaishi, MD, PhD
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Surgery ,RD1-811 - Abstract
Background:. In Japan, oral propranolol (PPL) and pulsed dye laser are available for infantile hemangioma (IH) treatment without patient cost-sharing. However, no standardized algorithm exists to guide treatment selection that balances efficacy, potential side effects, and aesthetic risks. This study presents a comprehensive approach utilizing a treatment algorithm and aesthetic risk scoring system. Methods:. This retrospective study analyzed outcomes from 156 patients with IHs. Oral PPL was used in IH patients with functional issues, whereas the rest underwent an aesthetic risk assessment that categorized them into low-, moderate-, or high-risk groups to guide treatment choices. Final treatment decisions depended on parental preference. The outcomes of algorithm-compliant and noncompliant patients were compared statistically. Results:. The risk score's interrater reliability was 0.973 (95% confidence interval 0.933–0.992), with a mean intrarater reliability of 0.968 ± 0.027 and a mean evaluation time of 14.1 ± 5.0 seconds per case. Among the 156 patients, 88% pursued the algorithm-recommended treatment, whereas 12% opted for different approaches. Algorithm-compliant patients experienced significantly fewer sequelae than did noncompliant patients (5% versus 33%, P < 0.001). Compared with noncompliant patients, algorithm-compliant patients tended to require shorter treatment durations (17.9 versus 25.4 mo, P = 0.08) and fewer laser sessions (5.8 versus 7.2, P = 0.30), with a younger age at resolution (21.3 versus 29.0 mo, P = 0.08). Conclusions:. Aesthetic concerns can be crucial for patients with IHs. This study introduces a comprehensive IH management algorithm to reduce the sequelae requiring surgical interventions and improve patients’ quality of life.
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- 2024
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18. Active surveillance vs. surgery in low‐risk papillary thyroid microcarcinoma patients and the risk of loss to follow‐up
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Yoshiyuki Saito, Kenichi Matsuzu, Hiroshi Takami, Ai Matsui, Yoko Kuga, Ryoji Ohara, Kana Yoshioka, Chie Masaki, Junko Akaishi, Kiyomi Y. Hames, Ritsuko Okamura, Chisato Tomoda, Akifumi Suzuki, Wataru Kitagawa, Mitsuji Nagahama, Kiminori Sugino, and Koichi Ito
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active surveillance ,adherence ,loss to follow up ,papillary thyroid microcarcinoma ,thyroidectomy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Papillary thyroid microcarcinoma (PTMC) management has evolved, with active surveillance (AS) gaining prominence as a management option. However, a key concern for both clinicians and patients is the potential for patient loss to follow‐up during AS. Aims This study aimed to determine adherence and loss‐to‐follow‐up rates in low‐risk PTMC patients undergoing AS versus surgical intervention, in order to gain insights into clinical pathways and safety profiles. Materials and Methods This cohort study analyzed the 2016 data from a single registered institution of Japan's public National Cancer Registry. Results We identified and retrospectively analyzed the cases of 327 patients diagnosed with low‐risk PTMC; 227 patients chose to undergo AS while the other 100 underwent PTMC surgery. Main outcomes were the adherence rate and loss‐to‐follow‐up rate of each group, factors influencing discontinuation, and safety considerations. The rate of AS adoption was substantial in the complete series of 327 low‐risk PTMC patients (69.4%). There was a significantly higher loss‐to‐follow‐up rate at 5 years in the AS group (28.6%) compared to the Surgery group (17.8%) (HR 1.62, 95% CI: 1.01–2.61; p = 0.046). Both univariate and multivariate analyses confirmed the significantly higher loss‐to‐follow‐up rate in the AS group as well as in older patients. No deaths due to PTMC progression were observed in the cases lost to follow‐up. Conclusion Despite concerns about loss to follow‐up, active surveillance remains a safe option for low‐risk PTMCs. Consistent follow‐up strategies are crucial, and further research is needed to enhance patient counseling and care for the management of patients with PTMC.
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- 2024
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19. High-frequency Power Doppler Ultrasonography in Predicting Burn Depth: A Preliminary Case Report
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Yusaku Saijo, MD, Satoshi Akaishi, MD, PhD, and Hiroaki Kuwahara, MD, PhD
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Surgery ,RD1-811 - Abstract
Summary:. Accurate burn depth assessment is essential to decide an appropriate surgical procedure. However, most cases of burn depth are diagnosed with subjective judgment by an experienced plastic surgeon. There is a need for a simple, noninvasive, and accurate diagnostic method. Here, the authors present two burn cases in which burn depth was predicted using high-frequency power Doppler ultrasonography. In case 1, the patient showed partial deep burn area prediagnosed by clinical inspection in dorsal area. However, pulsatile microcirculation was detected in the deep dermal layer using high-frequency power Doppler ultrasonography, and we rediagnosed it as deep dermal burn. Tangential excision was performed to debride necrotic tissue, preventing excessive removal of viable dermal tissue. In case 2, the patient showed anterior chest burn covered eschar. Pulsatile microcirculation was detected in the dermis using high-frequency power Doppler ultrasonography. The authors diagnosed the area as superficial dermal burn and opted for conservative treatment. Dermal microvascular damage is a more sensitive indicator of tissue injury. Hence, the burn depth can be assessed using dermal microcirculation. To the best of the authors’ knowledge, there are no reports on the evaluation of blood flow in burn wounds using high-frequency power Doppler ultrasonography. In this case report, the authors introduce the possibility of using high-frequency ultrasonography to assess burn depth.
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- 2024
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20. Discordance Between the Initial Diagnosis of Sarcomas and Subsequent Histopathological Revision and Molecular Analyses in a Sarcoma Reference Center in Brazil
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Carlos Diego H. Lopes, Marcello M. Queiroz, Luana A.F. Sampaio, André Perina, Eduardo Akaishi, Frederico Teixeira, Fábio de O. Ferreira, Samir A. Hanna, João Luís F. da Silva, Luiz Guilherme C.A. De Lima, Claudia Regina G.C.M. de Oliveira, and Rodrigo R. Munhoz
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
PURPOSETo investigate the discordance in sarcoma diagnoses between nonspecialized institutions following revision by dedicated sarcoma pathologists at a reference center in Brazil and the relevance of molecular pathology in this context.METHODSWe conducted a retrospective analysis of sarcoma samples initially analyzed at outside laboratories and subsequently reviewed by two specialized pathologists between January 2014 and December 2020. After obtaining demographic and tumor characteristics, pathology results were matched and classified as complete discordance (CD; benign v malignant, sarcoma v other malignancies), partial concordance (similar diagnosis of connective tumor, but different grade/histological subtype/differentiation), and complete concordance (CC). The concordance for histology or grade, and the role of molecular assessments supporting the diagnosis were also independently determined. Statistical analyses were conducted through the kappa coefficient of agreement and adherence by χ2 test, χ2 test by Person, and Fisher exact test.RESULTSIn total, 197 cases were included, with samples obtained predominately from male patients (57.9%) and localized/primary tumors (86.8%). Following revision, the most frequent final diagnoses were undifferentiated pleomorphic sarcoma (17.8%), well-differentiated/dedifferentiated liposarcoma (8.6%), and leiomyosarcoma (7.6%). CD was found in 13.2%, partial discordance in 45.2%, and CC in 41.6% of reviews (P < .001). We found a concordance for histology or grade of 53.5% (P < .001) and 51.8% (P < .001), respectively. Molecular assessments, comprising next-generation sequencing panels (79.5%) and fluorescent in situ hybridization (20.5%), were performed in 44 (22.3%) cases, with findings classified as of diagnostic relevance in 31.8%.CONCLUSIONIn nearly 60% of the cases, the initial sarcoma diagnosis was modified when revised by a reference center and dedicated pathologists, assisted by molecular pathology techniques. These results justify the assembly of referral networks in countries with limited health care resources.
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- 2024
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21. Multivisceral resection for retroperitoneal liposarcoma-is it worth it? A 20-year single-center experience
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Teixeira, Jr., Frederico Ribeiro, Arakaki, Mariana Sousa, Lima, Helber Vidal Gadelha, Ferreira, Fabio de Oliveira, Menegozzo, Carlos Augusto Metidieri, Silva, Eduardo Rissi, Montero, Edna Frasson de Souza, Oya, Toshiko, Lima, Luiz Calima, Akaishi, Eduardo Hiroshi, and Utiyama, Edivaldo Massazo
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- 2023
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22. Modified Technique of Setting Capsulotomy Thickness in Reducing Capsulotomy-Related Complications During Femtosecond Laser-Assisted Cataract Surgery: A Prospective, Comparative Cohort Study
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Teshigawara, Takeshi, Akaishi, Miki, Mizuki, Yuki, Takeuchi, Masaki, Hata, Seiichiro, Meguro, Akira, and Mizuki, Nobuhisa
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- 2023
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23. Recent results and future prospects of kaonic nuclei at J-PARC
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Sakuma, F., Ajimura, S., Akaishi, T., Asano, H., Bazzi, M., Beer, G., Bhang, H., Bragadireanu, M., Buehler, P., Busso, L., Cargnelli, M., Choi, S., Clozza, A., Curceanu, C., Enomoto, S., Fujioka, H., Fujiwara, Y., Fukuda, T., Guaraldo, C., Hashimoto, T., Hayano, R. S., Hiraiwa, T., Iio, M., Iliescu, M., Inoue, K., Ishiguro, Y., Ishikawa, T., Ishimoto, S., Itahashi, K., Iwasaki, M., Iwai, M., Kanno, K., Kato, K., Kato, Y., Kawasaki, S., Kienle, P., Kou, H., Ma, Y., Marton, J., Matsuda, Y., Miliucci, M., Mizoi, Y., Morra, O., Murayama, R., Nagae, T., Noumi, H., Ohnishi, H., Okada, S., Outa, H., Ozawa, K., Piscicchia, K., Sada, Y., Sakaguchi, A., Sato, M., Scordo, A., Sekimoto, M., Shi, H., Shirotori, K., Simon, M., Sirghi, D., Sirghi, F., Suzuki, S., Suzuki, T., Tanida, K., Tatsuno, H., Tokuda, M., Tomono, D., Toyoda, A., Tsukada, K., Doce, O. Vázquez, Widmann, E., Yamaga, T., Yamazaki, T., Yoshida, C., Zhang, Q., and Zmeskal, J.
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Nuclear Experiment ,Nuclear Theory - Abstract
$\bar K$-nuclear bound systems, kaonic nuclei, have been widely discussed as products of the strongly attractive $\bar K N$ interaction in $I = 0$ channels. Recently, we demonstrated that kaonic nuclei can be produced via in-flight $(K^-,N)$ reactions using the low-momentum DC kaon beam at the J-PARC E15 experiment. We observed the simplest kaonic nuclei, $K^-pp$, having a much deeper binding energy than normal nuclei. For further studies, we have proposed a series of experimental programs for the systematic investigation of light kaonic nuclei, from $\bar K N$ ($\Lambda(1405)$) to $\bar K NNNN$. In the new experiment approved as J-PARC E80, we will measure the $\bar K NNN$ ($A=3$) system as a first step toward a comprehensive study., Comment: 10 pages, 5 figures, proceedings of the 8th Asia-Pacific Conference on Few-Body Problems in Physics (APFB2020), accepted for publication in Fwe-Body Systems
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- 2021
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24. Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications
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Nildevande Firmino Lima-Jr, Marcello Moro Queiroz, Julia Sousa Leal Franco, Domingos Savio do Rego Lins-Junior, Eduardo Felício de Campos, Beatriz Mendes Awni, Luiz Guilherme Cernaglia Aureliano de Lima, Frederico Teixeira, Fábio de Oliveira Ferreira, Eduardo Hiroshi Akaishi, Fernanda Cunha Capareli, and Rodrigo Ramella Munhoz
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gastrointestinal stromal tumors ,sarcoma ,tyrosine kinase inhibitors ,proto-oncogene proteins c-kit ,platelet-derived growth factor ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Medicine - Abstract
Recognition of the molecular basis of gastrointestinal stromal tumors has paved the way for significant breakthroughs in the diagnosis and treatment of this disease as well as positioned gastrointestinal stromal tumors as a framework for the concept of precision oncology in solid tumors. The incorporation of novel targeted agents for molecularly defined subgroups has led to significant improvements in treatment outcomes; however, the characterization of heterogeneous KIT or PDGFRA mutations and the emergence of resistance mechanisms highlight the need for a broader use of comprehensive molecular profiling and emphasize the importance of molecularly driven adaptive treatment strategies. Such a molecular background is critical for developing personalized and effective interventions and optimizing outcomes. The present review summarizes key studies that provide the basis for standard-of-care management options as well as provides molecular insights into the management of gastrointestinal stromal tumors, with an emphasis on recent advances.
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- 2024
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25. Preserving the medial arm of the iliofemoral ligament in total hip arthroplasty using the anterolateral approach: Surgical outcomes and patient-reported outcome measure with 2 years follow-up
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Yoshifumi Harada, Yuji Yamamoto, Kazuki Oishi, Ryo Inoue, Koichi Akaishi, and Yasuyuki Ishibashi
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Total hip arthroplasty ,Anterolateral approach ,Iliofemoral ligament ,Capsule ,Preservation ,Patient-reported outcome ,Surgery ,RD1-811 - Abstract
Purpose: Iliofemoral ligament (ILFL) is a capsular ligament located in the anterosuperior part of the hip joint capsule and contributes to hip joint stability. The purpose of this study was to compare the surgical outcomes of resection versus preservation procedure of the medial arm of the ILFL in total hip arthroplasty (THA) using the anterolateral approach. Methods: Perioperative outcomes, complication, implant placement and patient-reported outcome measures (PROMs) were evaluated in 42 patients in the resection group and 38 patients in the preservation group. As a PROM, the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ), was administered at 6 months, 1 year and 2 years postoperatively. Results: There was no significant difference in perioperative outcomes, complication and implant placement between the two groups. Satisfaction for the hip joint condition (80.6 ± 22.4 vs 89.2 ± 20.1), JHEQ pain score (21.5 ± 4.5 vs 24.1 ± 5.2) at 6 months, and JHEQ pain score (21.6 ± 5.1 vs 23.5 ± 5.5) at 1 year were significantly better in the preservation group than in the resection group. At 2 years postoperatively, no significant difference was found in PROMs between the two groups. Conclusion: Our results indicate that preservation of the medial arm of the ILFL in THA improves pain during the first postoperative year without increased complications or disadvantages of implant placement. Preserving the medial arm of the ILFL may be a safe and effective option to improve the early clinical outcomes after THA using the anterolateral approach.
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- 2023
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26. Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity
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Hiroki Furuie, Yuka Kimura, Tatsuhiro Akaishi, Misa Yamada, Yoshiki Miyasaka, Akiyoshi Saitoh, Norihiro Shibuya, Akiko Watanabe, Naoki Kusunose, Tomoji Mashimo, Takeo Yoshikawa, Mitsuhiko Yamada, Kazuho Abe, and Hideo Kimura
- Subjects
Medicine ,Science - Abstract
Abstract Hydrogen sulfide (H2S) and polysulfides (H2Sn, n ≥ 2) are signaling molecules produced by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles, including the induction of hippocampal long-term potentiation (LTP), a synaptic model of memory formation, by enhancing N-methyl-d-aspartate (NMDA) receptor activity. However, the presynaptic action of H2S/H2Sn on neurotransmitter release, regulation of LTP induction, and animal behavior are poorly understood. Here, we showed that H2S/H2S2 applied to the rat hippocampus by in vivo microdialysis induces the release of GABA, glutamate, and d-serine, a co-agonist of NMDA receptors. Animals with genetically knocked-out 3MST and the target of H2S2, transient receptor potential ankyrin 1 (TRPA1) channels, revealed that H2S/H2S2, 3MST, and TRPA1 activation play a critical role in LTP induction, and the lack of 3MST causes behavioral hypersensitivity to NMDA receptor antagonism, as in schizophrenia. H2S/H2Sn, 3MST, and TRPA1 channels have therapeutic potential for psychiatric diseases and cognitive deficits.
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- 2023
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27. Blessing or Curse of Democracy?: Current Evidence from the Covid-19 Pandemic
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Badman, Ryan P., Wu, Yunxin, Inukai, Keigo, and Akaishi, Rei
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Economics - General Economics ,Quantitative Biology - Other Quantitative Biology - Abstract
Background: A major question in Covid-19 research is whether democracies handled the Covid-19 pandemic crisis better or worse than authoritarian countries. However, it is important to consider the issues of democracy versus authoritarianism, and state fragility, when examining official Covid-19 death counts in research, because these factors can influence the accurate reporting of pandemic deaths by governments. In contrast, excess deaths are less prone to variability in differences in definitions of Covid-19 deaths and testing capacities across countries. Here we use excess pandemic deaths to explore potential relationships between political systems and public health outcomes. Methods: We address these issues by comparing the official government Covid-19 death counts in a well-established John Hopkins database to the generally more reliable excess mortality measure of Covid-19 deaths, taken from the recently released World Mortality Dataset. We put the comparison in the context of the political and fragile state dimensions. Findings: We find (1) significant potential underreporting of Covid-19 deaths by authoritarian governments and governments with high state fragility and (2) substantial geographic variation among countries and regions with regard to standard democracy indices. Additionally, we find that more authoritarian governments are (weakly) associated with more excess deaths during the pandemic than democratic governments. Interpretations: The inhibition and censorship of information flows, inherent to authoritarian states, likely results in major inaccuracies in pandemic statistics that confound global public health analyses. Thus, both excess pandemic deaths and official Covid-19 death counts should be examined in studies using death as an outcome variable., Comment: 21 pages, 2 main figures, 1 main table, 1 supplementary data table
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- 2021
28. Write-ups for workshop on the project for the hadron experimental facility of J-PARC, Partial collection of LOIs at the extended hadron hall and the related topics
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Association, Hadron Hall Users', Achenbach, P., Ahn, J. K., Ajimura, S., Akaishi, T., Akaishi, Y., Andersson, W. Ikegami, Aoki, K., Asano, H., Bleser, S., Botta, E., Bölting, M., Chang, WC., Feliciello, A., Fujioka, H., Hassanvand, M., Honda, R., Ichikawa, Y., Ishikawa, T., Itahashi, K., Komatsu, Y., Miwa, K., Miyachi, Y., Morino, Y., Nakano, T., Nakamura, S. N., Naruki, M., Noumi, H., Ohnishi, H., Okada, S., Ozawa, K., Pochodzalla, J., Sako, H., Sakuma, F., Sawada, T., Schupp, F., Shirotori, K., Steinen, M., Sugaya, Y., Suzuki, K., Takahashi, H., Takahashi, T., Takahashi, T. N., Tanaka, K., Tomida, N., Ukai, M., Yamaga, T., Yamamoto, T., Yamazaki, T., Yang, S., Yue, M., and Collaboration, J-PARC KOTO
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Nuclear Experiment ,High Energy Physics - Experiment - Abstract
This write-up document is a summary of International workshop on the project for the extended hadron experimental facility which was held from March 26 to 28, 2018 at KEK Tokai Campus. This document is a collection of Letter Of Intents (LOIs) related to the proposed beam lines in the extended hadron experimental facility at J-PARC.
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- 2019
29. Modified Technique of Setting Capsulotomy Thickness in Reducing Capsulotomy-Related Complications During Femtosecond Laser-Assisted Cataract Surgery: A Prospective, Comparative Cohort Study
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Takeshi Teshigawara, Miki Akaishi, Yuki Mizuki, Masaki Takeuchi, Seiichiro Hata, Akira Meguro, and Nobuhisa Mizuki
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Anterior capsule ,Cataract surgery ,Incomplete capsulotomy ,Femtosecond laser ,Modified ,Tags ,Ophthalmology ,RE1-994 - Abstract
Abstract Introduction Although uncommon, incomplete capsulotomy, anterior capsule tags and anterior capsule tears are still encountered during femtosecond laser-assisted cataract surgery (FLACS), resulting in surgical complications. This highlights the need to improve femtosecond laser-assisted capsulotomy technique to reduce capsulotomy-related complications. Therefore, the purpose of this study was to investigate the efficacy of a newly developed, modified technique of setting capsulotomy irradiation thickness in lowering the incidence of capsulotomy-related complications in FLACS. Methods This open-label prospective, comparative cohort study included 440 eyes (220 patients) treated with FLACS using the LenSx laser system (Alcon Laboratories, Inc. Fort Worth, TX, USA). Varying capsulotomy irradiation thicknesses were applied in each eye of the same patient. In Group 1, capsulotomy irradiation thickness was set between the upper edge of the highest point of the anterior capsule and the lower edge of the lowest point of the anterior capsule (modified technique). In Group 2, this was set between the center of the highest point of the anterior capsule and the center of the lowest part of the anterior capsule (conventional technique). Incidence rates of incomplete capsulotomy, anterior capsule tags and tears, and posterior capsule tears were compared. Results Preoperative baseline characteristics showed no significant differences. Mean total of the irradiation thicknesses was 877.1 ± 81.9 µm in Group 1 and 808.9 ± 80.0 in Group 2, with a statistically significant difference (P
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- 2023
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30. Observation of Coulomb-assisted nuclear bound state of $\Xi^-$-$^{14}$N system
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Hayakawa, S. H., Agari, K., Ahn, J. K., Akaishi, T., Akazawa, Y., Ashikaga, S., Bassalleck, B., Bleser, S., Ekawa, H., Endo, Y., Fujikawa, Y., Fujioka, N., Fujita, M., Goto, R., Han, Y., Hasegawa, S., Hashimoto, T., Hayakawa, T., Hayata, E., Hicks, K., Hirose, E., Hirose, M., Honda, R., Hoshino, K., Hoshino, S., Hosomi, K., Hwang, S. H., Ichikawa, Y., Ichikawa, M., Imai, K., Inaba, K., Ishikawa, Y., Ito, H., Ito, K., Jung, W. S., Kanatsuki, S., Kanauchi, H., Kasagi, A., Kawai, T., Kim, M. H., Kim, S. H., Kinbara, S., Kiuchi, R., Kobayashi, H., Kobayashi, K., Koike, T., Koshikawa, A., Lee, J. Y., Ma, T. L., Matsumoto, S. Y., Minakawa, M., Miwa, K., Moe, A. T., Moon, T. J., Moritsu, M., Nagase, Y., Nakada, Y., Nakagawa, M., Nakashima, D., Nakazawa, K., Nanamura, T., Naruki, M., Nyaw, A. N. L., Ogura, Y., Ohashi, M., Oue, K., Ozawa, S., Pochodzalla, J., Ryu, S. Y., Sako, H., Sato, S., Sato, Y., Schupp, F., Shirotori, K., Soe, M. M., Soe, M. K., Sohn, J. Y., Sugimura, H., Suzuki, K. N., Takahashi, H., Takahashi, T., Takeda, T., Tamura, H., Tanida, K., Theint, A. M. M., Tint, K. T., Toyama, Y., Ukai, M., Umezaki, E., Watabe, T., Watanabe, K., Yamamoto, T. O., Yang, S. B., Yoon, C. S., Yoshida, J., Yoshimoto, M., Zhang, D. H., and Zhang, Z.
- Subjects
Nuclear Experiment - Abstract
In an emulsion-counter hybrid experiment performed at J-PARC, a $\Xi^-$ absorption event was observed which decayed into twin single-$\Lambda$ hypernuclei. Kinematic calculations enabled a unique identification of the reaction process as $\Xi^{-} + ^{14}$N$\ \rightarrow\ ^{10}_\Lambda$Be + $^5_\Lambda$He. For the binding energy of the $\Xi^{-}$ hyperon in the $\Xi^-$-$^{14}$N system a value of $1.27 \pm 0.21$ MeV was deduced. The energy level of $\Xi^-$ is likely a nuclear $1p$ state which indicates a weak ${\Xi}N$-$\Lambda\Lambda$ coupling.
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- 2020
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31. Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity
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Furuie, Hiroki, Kimura, Yuka, Akaishi, Tatsuhiro, Yamada, Misa, Miyasaka, Yoshiki, Saitoh, Akiyoshi, Shibuya, Norihiro, Watanabe, Akiko, Kusunose, Naoki, Mashimo, Tomoji, Yoshikawa, Takeo, Yamada, Mitsuhiko, Abe, Kazuho, and Kimura, Hideo
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- 2023
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32. White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease
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Akaishi, Tetsuya, Misu, Tatsuro, Fujihara, Kazuo, Nakaya, Kumi, Nakaya, Naoki, Nakamura, Tomohiro, Kogure, Mana, Hatanaka, Rieko, Itabashi, Fumi, Kanno, Ikumi, Kaneko, Kimihiko, Takahashi, Toshiyuki, Fujimori, Juichi, Takai, Yoshiki, Nishiyama, Shuhei, Ishii, Tadashi, Aoki, Masashi, Nakashima, Ichiro, and Hozawa, Atsushi
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- 2023
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33. Multiple linear regression model for improving accuracy of capsulorhexis size calculation in femtosecond laser-assisted cataract surgery for adults: a retrospective single-center study
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Akaishi, Miki, Teshigawara, Takeshi, Hata, Seiichiro, Meguro, Akira, and Mizuki, Nobuhisa
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- 2023
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34. White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease
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Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Kimihiko Kaneko, Toshiyuki Takahashi, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, and Atsushi Hozawa
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Medicine ,Science - Abstract
Abstract White blood cell (WBC) count profiles in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are still unknown. This study evaluated the total WBC count, differential WBC counts, monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with these diseases within three months from an attack before acute treatment or relapse prevention and compared the profiles with those in matched volunteers or in multiple sclerosis (MS) patients. AQP4-NMOSD patients (n = 13) had a higher neutrophil count (p = 0.0247), monocyte count (p = 0.0359), MLR (p = 0.0004), and NLR (p = 0.0037) and lower eosinophil (p = 0.0111) and basophil (p = 0.0283) counts than those of AQP4-NMOSD-matched volunteers (n = 65). Moreover, patients with MOGAD (n = 26) had a higher overall WBC count (p = 0.0001), neutrophil count (p
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- 2023
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35. Impact of Age on Prognosis in Papillary Thyroid Carcinoma: How Should Age be Incorporated into the Treatment Strategy?
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Sugino, Kiminori, Matsuzu, Kenichi, Nagahama, Mitsuji, Kitagawa, Wataru, Suzuki, Akifumi, Tomoda, Chisato, Hames, Kiyomi Yamada, Akaishi, Junko, Masaki, Chie, Yoshioka, Kana, Saito, Yoshiyuki, and Ito, Koichi
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- 2023
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36. Statistical evaluation of cluster formation of relapse in neuromyelitis optica spectrum disorder
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Tetsuya Akaishi and Ichiro Nakashima
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2024
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37. Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study
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Yu Akaishi, Nobutoshi Nawa, Ayako Kashimada, Yasuhiro Itsui, Eriko Okada, and Masanaga Yamawaki
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Grit ,depressive symptoms ,medical resident ,COVID-19 pandemic ,timing of job start ,Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
ABSTRACTIntroduction The COVID-19 pandemic had an additional negative impact on the mental health of healthcare workers, including residents. Previous studies revealed that grit, which is an individual trait to achieve long-term goals unrelated to intelligence quotient, is not only positively associated with academic achievement and career success but also negatively correlated with depression. This study aimed to examine the association between grit and depressive symptoms among residents at the time of job start during the coronavirus disease 2019 (COVID-19) pandemic in Japan.Materials and methods This cross-sectional study used data from all post-graduate year 1 residents from March 2020 to April 2022 at Tokyo Medical and Dental University, Tokyo, Japan. Grit was measured by the Japanese version of Grit-S. The resident’s depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. The association of interest was examined using logistic regression analysis.Results Among 221 residents, 28 (12.7%) have depressive symptoms. One unit increase in Grit-S score after adjusting for age, sex, graduated university, and sleeping hours was associated with lower odds of having depressive symptoms by 63% (odds ratio [OR]: 0.37; 95% confidence interval [CI]: 0.19–0.74). Further, the perseverance of effort subscale score was associated with lower odds of having depressive symptoms after covariate adjustment (OR: 0.43; 95% CI: 0.22–0.84).Conclusions Higher grit scores were associated with lower odds of having depressive symptoms among residents at the timing of job start during the COVID-19 pandemic. Regular mental health assessment is particularly important for residents with low grit scores at entry.
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- 2023
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38. Utilizing 3D Printing for the Surgical Management of Orbital Floor Fractures
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Sakurako Mukai, MD, Takuya Tsuge, MD, PhD, Satoshi Akaishi, MD, PhD, Rei Ogawa, MD, PhD, FACS, and Hiroaki Kuwahara, MD, PhD
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Surgery ,RD1-811 - Abstract
Summary:. We present a technique for treating orbital floor fractures using three-dimensional (3D) printing technology and a preoperative template based on the mirror image of the unaffected orbit. Our patient, a 56-year-old man, experienced persistent diplopia in the upward direction and left enophthalmos after previous open reduction internal fixation surgery. To address these complications, we used a simulation of the ideal orbital floor from computed tomography images and used a 3D printer to create a template. Subsequently, an absorbable plate was molded intraoperatively based on this template. Notably, the plate fit seamlessly into the fracture site without requiring any adjustment, reducing the operation time. Postoperative computed tomography scans confirmed successful reduction, improved visual function, and the absence of complications. Our method offers a precise and efficient approach to reconstructing fractured orbital floors. By leveraging 3D printing technology and preoperative templates, surgeons can enhance postoperative outcomes and minimize patient burden. Further investigations are warranted to assess the long-term effectiveness and cost-effectiveness of this technique. Our findings highlight the potential of this approach to improve treatment strategies for patients with orbital floor fractures.
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- 2023
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39. Elucidation of the needs for telecritical care services in Japan: a qualitative study
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MASANAGA YAMAWAKI, Nobutoshi Nawa, Mizuki Morimoto, Eriko Okada, Yasuhiro Itsui, Ayako Kashimada, Kouhei Yamamoto, and Yu Akaishi
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Medicine - Abstract
Objective To clarify the reasons for consultation, advice sought by frontline physicians and relationship between the patient’s pathology and the type of advice provided to guide the future development of telecritical care services.Design Secondary analysis of transcripts of telephone calls originally recorded for quality control purposes was conducted using a thematic content analysis. The calls were conducted between December 2019 and April 2021 (total cases: 70; total time: ~15 hour).Settings Intensivists provided consultation services to frontline physicians at secondary care institutions in the Kansai and Chubu regions.Participants Non-intensive care frontline physicians working in five secondary care institutions in the Kansai and Chubu regions and intensivists providing a consultation service (n=26).Interventions Not applicable.Primary and secondary outcome measures The main outcome was the themes emerging from the language used during telephone and video consultations, indicating the gap filled by the telecritical care service.Findings We analysed 70 cases and approximately 15 hours of anonymised audio data. We identified the following reasons for consultation: ‘lack of competence in treatment and diagnostic testing’ and ‘lack of access to consultation in their own hospital’. Frontline physicians most often sought advice related to ‘treatment’, followed by ‘patient triage and transfer’, ‘diagnosis’ and ‘diagnostic testing and evaluation’. Regarding the relationship between the patient’s pathology and type of advice provided, the most commonly sought advice by frontline physicians varied based on the patient’s pathology.Conclusion This study explored the characteristics of 70 telecritical sessions and identified the reasons for and nature of the consultations. These findings can be used to guide the future provision and scale up of telecritical services.
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- 2023
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40. Precise lifetime measurement of Λ4H hypernucleus using in-flight 4He(K−,π0)Λ4H reaction
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T. Akaishi, H. Asano, X. Chen, A. Clozza, C. Curceanu, R. Del Grande, C. Guaraldo, C. Han, T. Hashimoto, M. Iliescu, K. Inoue, S. Ishimoto, K. Itahashi, M. Iwasaki, Y. Ma, M. Miliucci, R. Murayama, H. Noumi, H. Ohnishi, S. Okada, H. Outa, K. Piscicchia, A. Sakaguchi, F. Sakuma, M. Sato, A. Scordo, K. Shirotori, D. Sirghi, F. Sirghi, S. Suzuki, K. Tanida, T. Toda, M. Tokuda, T. Yamaga, X. Yuan, P. Zhang, Y. Zhang, and H. Zhang
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Strangeness exchange reaction ,π0 tagging ,Hypernuclear weak decay lifetime ,Physics ,QC1-999 - Abstract
We present a new measurement of the Λ4H hypernuclear lifetime using in-flight K− + 4He → Λ4H + π0 reaction at the J-PARC hadron facility. We demonstrate, for the first time, the effective selection of the hypernuclear bound state using only the γ-ray energy decayed from π0. This opens the possibility for a systematic study of isospin partner hypernuclei through comparison with data from (K−, π−) reaction. As the first application of this method, our result for the Λ4H lifetime, τ(HΛ4)=206±8(stat.)±12(syst.)ps, is one of the most precise measurements to date. We are also preparing to measure the lifetime of the hypertriton (Λ3H) using the same setup in the near future.
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- 2023
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41. EMPHATIC: A proposed experiment to measure hadron scattering and productioncross sections for improved neutrino flux predictions
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Akaishi, T., Aliaga-Soplin, L., Asano, H., Aurisano, A., Barbi, M., Bellantoni, L., Bhadra, S., Chang, W-C., Fields, L., Fiorentini, A., Friend, M., Fukuda, T., Harris, D., Hartz, M., Honda, R., Ishikawa, T., Jamieson, B., Kearns, E., Kolev, N., Komatsu, M., Komatsu, Y., Konaka, A., Kordosky, M., Lang, K., Lebrun, P., Lindner, T., Ma, Y., Caicedo, D. A. Martinez, Muether, M., Naganawa, N., Naruki, M., Niner, E., Noumi, H., Ozawa, K., Paley, J., Pavin, M., de Perio, P., Proga, M., Sakuma, F., Santucci, G., Sawada, T., Sato, O., Sekiguchi, T., Shirotori, K., Suzuki, A., Tabata, M., Takahashi, T., Tomida, N., Wendell, R., and Yamaga, T.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
Hadron scattering and production uncertainties are a limiting systematic on accelerator and at-mospheric neutrino flux predictions. New hadron measurements are necessary for neutrino fluxpredictions with well-understood and reduced uncertainties. We propose a new compact experimentto measure hadron scattering and production cross sections at beam energies that are inaccessibleto currently operating experiments. These measurements can reduce the current 10% neutrino fluxuncertainties by an approximate factor of two.
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- 2019
42. Kaonic Nuclear Clusters --- a New Paradigm of Particle and Nuclear Physics ---
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Akaishi, Y. and Yamazaki, T.
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Nuclear Theory - Abstract
Lambda*=Lambda(1405) plays an essential role in forming kaonic nuclear clusters (KNC). The simplest KNC, K-pp, has the structure Lambda*p=(K-p){I=0}p, where a real kaon migrates between two nucleons, mediating super-strong Lambda*-p$ attraction. Production data of K-pp have been accumulated by DISTO, J-PARC E27 and J-PARC E15 experiments. In the case of K-K-pp, the attractive covalent bond of Lambda*Lambda* is doubly enhanced compared to the Lambda*-p one. As a consequence, a m-th Lambda* multiplet, (Lambda*)m, with m(m-1)/2 bonds becomes more stable than its corresponding neutron aggregate, (n)m, with m=8 ~ 12. This may suggest the possible existence of stable Lambda* matter. The production of K-K-pp by high-energy pp or heavy-ion collisions is awaited as a doorway to so-far unknown Lambda* matter., Comment: 10 pages, 8 figures
- Published
- 2019
43. Response to neoadjuvant paclitaxel predicts survival in anaplastic thyroid carcinoma
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Haruhiko Yamazaki, Kiminori Sugino, Ryohei Katoh, Kenichi Matsuzu, Chie Masaki, Junko Akaishi, Kiyomi Yamada Hames, Chisato Tomoda, Akifumi Suzuki, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Yasushi Rino, and Koichi Ito
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anaplastic thyroid carcinoma ,neoadjuvant chemotherapy ,paclitaxel ,prognosis ,response ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract The clinical utilities of paclitaxel in anaplastic thyroid carcinoma (ATC) have been reported. The current study investigated the outcomes in ATC patients treated by paclitaxel as neoadjuvant setting. Furthermore, the prognostic factor for overall survival (OS) and predictive marker for response to paclitaxel were investigated. Records of ATC patients treated by paclitaxel as neoadjuvant setting in our hospital were reviewed. The median OS for the patients with (n = 43) and without (n = 23) resection were 14.7 (95% CI, 11.0–21.7) and 4.2 (95% CI, 3.0–5.4) months, respectively (p
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- 2023
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44. Multiple linear regression model for improving accuracy of capsulorhexis size calculation in femtosecond laser-assisted cataract surgery for adults: a retrospective single-center study
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Miki Akaishi, Takeshi Teshigawara, Seiichiro Hata, Akira Meguro, and Nobuhisa Mizuki
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Femtosecond ,Laser ,Cataract ,Adult ,Capsulorhexis ,Linear regression ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Differences between programmed capsulorhexis diameter and actual resulting capsulorhexis diameter (ARCD) are commonly encountered in femtosecond laser-assisted cataract surgery (FLACS). The purpose of this study was to identify the preoperative ophthalmic variables influencing capsulorhexis diameter index (CDI) in FLACS for adults and create a multiple linear regression model for obtaining a more accurate capsulorhexis diameter. Methods This retrospective study involved sixty-seven eyes of 44 patients who received FLACS and intraocular lens implantation. The ARCD was measured using anterior segment swept-source optical coherence tomography (CASIA 2). Keratometry (K1, K2 and average K), anterior chamber depth (ACD), lens thickness (LT), anterior chamber width (ACW), white-to-white (WTW), curvature radius of anterior lens capsule (Front R) and axial length (AL) were all measured preoperatively. Based on the derived data, LT/ACW, LT/AL, LT/ACD and LT/ACW/Front R were calculated. The ratio of the programmed capsulorhexis diameter and ARCD was defined as the CDI. Correlation analysis was conducted to examine the relationship between preoperative variables listed above and the CDI. Multiple linear regression analysis was applied to select the most influential preoperative variables on CDI. Results ACD, LT, ACW, Front R, AL, LT/ACW, LT/AL, LT/ACD, and LT/ACW/Front R showed significant correlation with CDI. Front R and LT/ACW/Front R were selected as constants in the multiple linear regression model using stepwise variable selection. The following equation represents the multiple linear regression model: CDI = 1.306–4.516 × LT/ACW/FrontR-0.011 × Front R, when P
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- 2023
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45. Predictors of maximum efficacy of lenvatinib for real-world patients with differentiated thyroid carcinoma
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Masaki, Chie, Sugino, Kiminori, Saito, Naoko, Akaishi, Junko, Hames, Kiyomi Y., Tomoda, Chisato, Suzuki, Akifumi, Matsuzu, Kenichi, Ohkuwa, Keiko, Kitagawa, Wataru, Nagahama, Mitsuji, and Ito, Koichi
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- 2022
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46. Successful dose escalation of lenvatinib for thyroid cancer after disease progression
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Masaki, Chie, Sugino, Kiminori, Akaishi, Junko, Hames, Kiyomi Y., Tomoda, Chisato, Suzuki, Akifumi, Matsuzu, Kenichi, Ohkuwa, Keiko, Kitagawa, Wataru, Nagahama, Mitsuji, and Ito, Koichi
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- 2022
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47. The neuroanatomy of social trust predicts depression vulnerability
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Alan S. R. Fermin, Toko Kiyonari, Yoshie Matsumoto, Haruto Takagishi, Yang Li, Ryota Kanai, Masamichi Sakagami, Rei Akaishi, Naho Ichikawa, Masahiro Takamura, Satoshi Yokoyama, Maro G. Machizawa, Hui-Ling Chan, Ayumu Matani, Shigeto Yamawaki, Go Okada, Yasumasa Okamoto, and Toshio Yamagishi
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Medicine ,Science - Abstract
Abstract Trust attitude is a social personality trait linked with the estimation of others’ trustworthiness. Trusting others, however, can have substantial negative effects on mental health, such as the development of depression. Despite significant progress in understanding the neurobiology of trust, whether the neuroanatomy of trust is linked with depression vulnerability remains unknown. To investigate a link between the neuroanatomy of trust and depression vulnerability, we assessed trust and depressive symptoms and employed neuroimaging to acquire brain structure data of healthy participants. A high depressive symptom score was used as an indicator of depression vulnerability. The neuroanatomical results observed with the healthy sample were validated in a sample of clinically diagnosed depressive patients. We found significantly higher depressive symptoms among low trusters than among high trusters. Neuroanatomically, low trusters and depressive patients showed similar volume reduction in brain regions implicated in social cognition, including the dorsolateral prefrontal cortex (DLPFC), dorsomedial PFC, posterior cingulate, precuneus, and angular gyrus. Furthermore, the reduced volume of the DLPFC and precuneus mediated the relationship between trust and depressive symptoms. These findings contribute to understanding social- and neural-markers of depression vulnerability and may inform the development of social interventions to prevent pathological depression.
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- 2022
- Full Text
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48. Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronaviruses
- Author
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Tetsuya Akaishi, Kei Fujiwara, and Tadashi Ishii
- Subjects
Bat coronavirus ,insertion/deletion (indel) ,Indel hotspot ,Pangolin coronavirus (PCoV) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Ecology ,QH540-549.5 ,Evolution ,QH359-425 - Abstract
Abstract The genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains many insertions/deletions (indels) from the genomes of other SARS-related coronaviruses. Some of the identified indels have recently reported to involve relatively long segments of 10–300 consecutive bases and with diverse RNA sequences around gaps between virus species, both of which are different characteristics from the classical shorter in-frame indels. These non-classical complex indels have been identified in non-structural protein 3 (Nsp3), the S1 domain of the spike (S), and open reading frame 8 (ORF8). To determine whether the occurrence of these non-classical indels in specific genomic regions is ubiquitous among broad species of SARS-related coronaviruses in different animal hosts, the present study compared SARS-related coronaviruses from humans (SARS-CoV and SARS-CoV-2), bats (RaTG13 and Rc-o319), and pangolins (GX-P4L), by performing multiple sequence alignment. As a result, indel hotspots with diverse RNA sequences of different lengths between the viruses were confirmed in the Nsp2 gene (approximately 2500–2600 base positions in the overall 29,900 bases), Nsp3 gene (approximately 3000–3300 and 3800–3900 base positions), N-terminal domain of the spike protein (21,500–22,500 base positions), and ORF8 gene (27,800–28,200 base positions). Abnormally high rate of point mutations and complex indels in these regions suggest that the occurrence of mutations in these hotspots may be selectively neutral or even benefit the survival of the viruses. The presence of such indel hotspots has not been reported in different human SARS-CoV-2 strains in the last 2 years, suggesting a lower rate of indels in human SARS-CoV-2. Future studies to elucidate the mechanisms enabling the frequent development of long and complex indels in specific genomic regions of SARS-related coronaviruses would offer deeper insights into the process of viral evolution.
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- 2022
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49. Insertion and deletion mutations preserved in SARS-CoV-2 variants
- Author
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Akaishi, Tetsuya and Fujiwara, Kei
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- 2023
- Full Text
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50. Measurement of KN scattering below the KN mass threshold
- Author
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Noumi Hiroyuki, Inoue Kentaro, Kawasaki Shingo, Aikawa Shuu, Ajimura Shuhei, Akaishi Takaya, Asano Hidemitsu, Beer George, Berucci Carolina, Bragadireau Mario, Buehler Paul Alois, Busso Luigi, Cargnelli Michael, Choi Seonho, Curceanu Catalina, Enomoto Shun, Fujioka Hiroyuki, Fujiwara Yuya, Fukuda Tomokazu, Guaraldo Carlo, Hashimoto Tadashi, Hayano Ryugo S., Hiraiwa Toshihiko, Iio Masami, Iliescu Mihai, Ishiguro Yusuke, Ishimoto Shigeru, Ishikawa Takashi, Ithashi Kenta, Iwai Massaki, Iwasaki Masahiko, Kanno Koki, Kato Kazuma, kato Yuko, Kienle Paul, Komatsu Yusuke, Kou Hiroshi, Ma Yue, Marton Johann, Matsuda Yasuyuki, MIzoi Yutaka, Morra Ombretta, Murayama Rie, Nagae To-mofumi, Ohnishi Hiroaki, Okada Shinji, Omar Zhadyra, Outa Haruhiko, Piscicchia Kristian, Sada Yuta, Sakaguchi Atsushi, Sakuma Fuminori, Sato Masaharu, Scordo Alessadro, Sekimoto Michiko, Shi Hexi, Shirotori Kotaro, Sirghi Diana, Sirghi Florin, Suzuki Ken, Suzuki Shoji, Suzuki Takatoshi, Tanida Kiyoshi, Tatsuno Hideyuki, Tokiyasu Atsushi O., Tokuda Makoto, Tomono Dai, Toyoda Akihisa, Tsukada Kyo, Vazquez-Doce Oton, Widmann Eberhard, Yamaga Takumi, Yamazaki Toshimitsu, Yim Heejoong, Zhang Qi, and Zmeskal Johannes
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Physics ,QC1-999 - Abstract
Abstract. We measured πE invariant mass spectra below and above the K¯N mass threshold in the K−d → NπE reaction in order to study the K¯N interaction and the Λ(1405) resonance. This reaction can be described by the two-step process: (i) K¯N1 → K¯N followed by (ii) K¯N2 → πΣ, where N1 and N2 are nucleons bound in the deuteron. We deduced the S -wave scattering amplitude of K¯N →K¯N in the framework of the K¯N πΣ coupled channel so as to reproduce the observed πΣ spectra in the I = 0 channel. We found a resonance pole at 1417.7-7.4+6.0 (fitting error)-1.0+1.1 (systematic error) - i[26.9-7.9+6.0 (fitting error)-2.0+1.7 (systematic error)]MeV/c2.
- Published
- 2024
- Full Text
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