127 results on '"Ajjala, Devender Reddy"'
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2. Simultaneous in-vivo receptor occupancy assays for serotonin 1A, 2A, and dopamine 2 receptors with the use of non-radiolabelled tracers: Proposed method in screening antipsychotics
3. Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance
4. Development and validation of sensitive LC–MS/MS method for the quantification of SUVN-502 and its metabolite and its application for first in human pharmacokinetic study
5. Dried blood spot analysis of an iron chelator – Deferasirox and its potential application to therapeutic drug monitoring
6. Approach to reduce the non-specific binding in microdialysis
7. Rat thalamic α4β2 neuronal nicotinic acetylcholine receptor occupancy assay using LC–MS/MS
8. LC–MS/MS method for the quantification of almotriptan in dialysates: Application to rat brain and blood microdialysis study
9. In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145
10. LC–MS/MS method for the quantification of aldose reductase inhibitor – Epalrestat and application to pharmacokinetic study
11. LC–MS/MS method for the quantification of SUVN-G3031, a novel H3 receptor inverse agonist for narcolepsy treatment
12. P2-031: SAFETY, TOLERABILITY AND HUMAN PHARMACOKINETICS OF SUVN-502, A POTENT AND PURE 5-HT6 RECEPTOR ANTAGONIST
13. LC–MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regions
14. 0053 SUVN-G3031: Safety, Tolerability and Pharmacokinetics of a Potent and Selective Histamine H3 Receptor Inverse Agonist - Single and Multiple Ascending Doses in Healthy Subjects
15. A definite measure of occupancy exposures, seeking with non-radiolabeled in vivo 5-HT2A receptor occupancy and in vitro free fractions
16. Assessment of sigma-1 receptor occupancy in mice with non-radiolabelled FTC-146 as a tracer
17. Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole
18. LC–MS/MS method for the simultaneous quantification of artemether, dihydroartemisinin and lumefantrine in rabbit plasma and its application to a PK study
19. Sensitive LC–MS/MS method for quantification of vitamin B 12 in rat serum: Application to pharmacokinetic study
20. [P2-033]: SUVN-502 + DONEPEZIL + MEMANTINE (TRIPLE COMBINATION) REPRESENTS A PROMISING NEW APPROACH FOR SYMPTOMATIC TREATMENT OF ALZHEIMER's DISEASE
21. [P1-063]: SUVN-G3031, A SELECTIVE H3 RECEPTOR INVERSE AGONIST: ASSESSMENT OF SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HEALTHY HUMAN VOLUNTEERS
22. [P1-460]: SUVN-D4010: A POTENT AND SELECTIVE 5-HT4 RECEPTOR PARTIAL AGONIST- ASSESSMENT OF SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HEALTHY HUMAN VOLUNTEERS
23. Incurred sample reanalysis of fingolimod and fingolimod phosphate in blood: stability evaluation and application to a rat pharmacokinetic study
24. Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole.
25. SAFETY, TOLERABILITY AND HUMAN PHARMACOKINETICS OF SUVN-502, A POTENT AND PURE 5-HT6 RECEPTOR ANTAGONIST
26. P2-062: Assessment of Central and Peripheral 5-Ht4 Receptor Occupancy in Rats
27. P3-016: SUVN-D4010, A Potent and Selective 5-HT4 Receptor Partial Agonist: Safety, Tolerability and Pharmacokinetics in Humans
28. P1-085: SUVN-502, Potent and Pure 5-HT6 Receptor Antagonist: Proof-of-Concept Study Design in Moderate Alzheimer’s Disease Patients
29. Skin sample preparation by collagenase digestion for diclofenac quantification using LC–MS/MS after topical application
30. Sensitive LC–MS/MS method for quantification of vitamin B12 in rat serum: Application to pharmacokinetic study
31. Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
32. P3‐296: Safety, tolerability, and pharmacokinetics of a potent and selective 5‐ht 6 receptor antagonist, SUVN‐502, following multiple ascending doses in healthy elderly subjects, and effect of gender and food on single‐dose pharmacokinetics
33. SUVN-502 + DONEPEZIL + MEMANTINE (TRIPLE COMBINATION) REPRESENTS A PROMISING NEW APPROACH FOR SYMPTOMATIC TREATMENT OF ALZHEIMER’S DISEASE
34. SUVN-D4010: A POTENT AND SELECTIVE 5-HT4 RECEPTOR PARTIAL AGONIST— ASSESSMENT OF SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HEALTHY HUMAN VOLUNTEERS
35. SUVN-G3031, A SELECTIVE H3 RECEPTOR INVERSE AGONIST: ASSESSMENT OF SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HEALTHY HUMAN VOLUNTEERS
36. Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays
37. P3‐390: EFFECT OF GENDER AND FOOD ON THE SINGLE‐DOSE PHARMACOKINETICS OF SUVN‐502, A POTENT AND SELECTIVE 5‐HT6 RECEPTOR ANTAGONIST
38. IN VIVO BRAIN RECEPTOR OCCUPANCY FOR PDE‐10 RECEPTORS IN MICE AND RATS USING NON‐RADIOLABELED TRACER
39. SUVN-D4010, A POTENT AND SELECTIVE 5-HT4 RECEPTOR PARTIAL AGONIST: SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HUMANS
40. ASSESSMENT OF CENTRAL AND PERIPHERAL 5-HT4 RECEPTOR OCCUPANCY IN RATS
41. SUVN-502, POTENT AND PURE 5-HT6 RECEPTOR ANTAGONIST: PROOF-OF-CONCEPT STUDY DESIGN IN MODERATE ALZHEIMER’S DISEASE PATIENTS
42. P1-037: 5-HT4 receptor occupancy assay in mice striatum using LC-MS/MS-based tracer analysis
43. LC‐MS/MS method for the determination of pitolisant: application to rat pharmacokinetic and brain penetration studies
44. P4-235: Pro-cognitive properties of SUVN-G1010034, a potent selective H3 antagonist in animal models of cognition
45. P3‐419: Neuronal nicotinic acetylcholine a4b2 receptor occupancy assay in rats using unlabelled ZW‐104 as tracer
46. Safety, tolerability, and pharmacokinetics of a potent and selective 5-ht6 receptor antagonist, SUVN-502, following multiple ascending doses in healthy elderly subjects, and effect of gender and food on single-dose pharmacokinetics
47. Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.
48. EFFECT OF GENDER AND FOOD ON THE SINGLE-DOSE PHARMACOKINETICS OF SUVN-502, A POTENT AND SELECTIVE 5-HT6 RECEPTOR ANTAGONIST
49. 5-HT4 receptor occupancy assay in mice striatum using LC-MS/MS-based tracer analysis
50. In-vivo rat striatal 5- HT4 receptor occupancy using non-radiolabelled SB207145.
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