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1. Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 Diabetes

Author

Ajda MUTLU MIHÇIOĞLU and Şükrü HATUN

Subjects
type 1 diabetes, diabetic ketoacidosis, vitamin d, Medicine
Abstract

Aim:This study is conducted to examine the correlation between vitamin D deficiency and type 1 diabetes since diabetes incidence is rising and recent studies have revealed extra osseous effects of vitamin D.Materials and Methods:Eighty patients with newly diagnosed type 1 diabetes and 30 patients with no systemic disease were included in the study. Serum 25-hydroxyvitamin D (25-OHD), parathormone (PTH), calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP) samples were obtained from both groups. Blood gas parameters were also obtained from the diabetic group. Information concerning vitamin D usage during pregnancy and infancy was acquired through personal interviews with patient’s mothers.Results:25-OHD levels were lower in the diabetic group than in the controls (24.43±16.25 ng/mL vs. 34.55±15.03 ng/mL, respectively, p=0.001), but the difference was not significant when seasonal variation was taken into consideration (33.44±17.23 ng/mL, vs. 34.55±15.03 ng/mL, p>0.05). Vitamin D levels were similar between the groups with ketoacidosis and non-acidotic group, p>0.05, for all). Ca, P, ALP and PTH levels were also similar at the time of diagnosis in the acidotic and non-acidotic groups (p>0.05, for all). The relationship between vitamin D use during pregnancy and infancy and the development of type 1 diabetes was similar between the diabetic and control groups (p>0.05).Conclusion:No significant effects of vitamin D deficiency/insufficiency on the development of diabetes and clinical status at admission was detected. Vitamin D intake in infancy and pregnancy exhibited no protective effect against the progression of diabetes. Therefore, it does not seem possible to reach a definitive conclusion about the relationship of vitamin D and type 1 diabetes.

Published
2022
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2. The Relationship between Arterial Elasticity Parameters of Ascending Aorta, Abdominal Aorta and Carotid Arteries with Carotid Intima Media Thickness in Children with Bicuspid Aortic Valve

Author

Ajda Mutlu Mıhçıoğlu, Feyza Paç, Muharrem Tola, Ahmet Vedat Kavurt, Serhat Koca, and Denizhan Bağrul

Subjects
abdominal aorta, aorta, bicuspid aortic valve, carotid intima-media thick-ness, children, echocardiography, elasticity, valvular and congenital heart disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Bicuspid aortic valve is a congenital cardiac malformation that affects not only the valve and ascending aorta but also the abdominal aorta and large central arteries like carotid arteries by damaging the elasticity of the vessel resulting in increased stiffness and reduced distensibility. Deterioration of aortic compliance disturbs functions of the left ventricle and triggers atherosclerosis determined with carotid intima-media thickness. The aim of this study was to assess the effect of the bicuspid aortic valve on the elastic properties of these parts of the arterial system in children. Methods: Thirty-four children with bicuspid aortic valves with normal valvular functions or mild valvular dysfunction and a control group of 34 individuals with tricuspid aortic valves were included in the study. Echocardiographic measurements of the left ventri-cle, ascending aorta, and ultrasonographic measurements of the abdominal aorta and carotid arteries were performed, and elasticity indexes were calculated. Results: The bicuspid aortic valve group had higher stiffness and lower distensibility in ascending aorta, abdominal aorta, and carotid arteries with higher carotid intima-media thickness values than the tricuspid aortic valve group. Aortic valvular z scores and ascending aorta and abdominal aorta stiffness were higher in patients with bicus-pid aortic valves irrespective of valvular functions than in controls. Valvular dysfunction affected stiffness in carotid arteries. Dilatation of ascending aorta increased stiffness in the abdominal aorta. Distensibility was lower in ascending aorta and left carotid artery, with increased carotid intima-media thickness independent from ascending aorta dilatation. Stiffness of abdominal aorta revealed a positive correlation with the stiffness of the ascending aorta and the carotid arteries (P

Published
2022
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3. Oral Research Presentations

Author

Hatice Gözde Akkın Gürbüz, Levent Turhan, Nilgun Şendil, Halim Ömer Kaşıkçı, Banu Salepçi, Derya Ipekcioglu, Canan Kuygun Karcı, Perihan Çam Ray, Ayşegül Yolga Tahiroğlu, Ayşe Avcı, Gonca Gül Çelik, Necmi Cekin, Nurdan Evliyaoğlu, Mehmet Alkanat, Hafize Özdemir, Egemen Akgün, Mehmet Emin Demirkol, Lut Tamam, Erman Esnafoglu, Doğa Sevinçok, Çağdaş Öykü Memiş, Bilge Doğan, Burcu Çakaloz, Ayşe Kutlu, Levent Sevinçok, Sema Nur Türkoğlu Dikmen, Yasir Şafak, Rıza Gökçer Tulacı, İlker Özdemir, Sema Baykara, Kübra Alban, Nazan Aydın, Hasan Mervan Aytaç, Doğan Yılmaz, Pınar Çetinay Aydın, Gökşen Yüksel Yalçın, Cana Canbay, Merve Terzioğlu, Aysel Özer, Ebru Altintas, Meryem Özlem Kütük, Ali Evren Tufan, Harika Gözükara Bağ, Güliz Şenormancı, Oya Güçlü, Cemil Çelik, Abdullah Bolu, Taner Öznur, Mehmet Sinan Aydın, Yusuf Tokgöz, Özcan Uzun, Sakır Gıca, Burç Çağrı Poyraz, Yağmur Sever Fidan, Hüseyin Güleç, Erdoğdu Akça, Mesut Yıldız, Zeynep Nur Demirok Akça, Yusuf Öztürk, Gonca Özyurt, Kadir Özdel, Gulcin Elboga, Muhammet Berkay Ozyurek, Abdullah Akgün, Ali Coşkun, Ayhan Bilgiç, Rukiye Çolak Sivri, İbrahim Kılınç, Ahmet İnal, Uğur Eray, Murat Acat, Arif Önder, Aslı Sürer Adanır, Canem Kavurma, Öznur Bilaç, Yakup Doğan, Rukiye Ay, Çağatay Uğur, Betül Gül Alıç, Mehmet Gündüz, Özlem Ünal, Ömer Uçur, Özlem Özcan, Hasret Karabulut Gül, Demet Sağlam Aykut, Ahmet Tiryaki, Filiz Civil Arslan, Gül Alkan Bülbül, Ömer Yolcu, Aysel Uysal, Esin Özatalay, Selma Cırrık, Esin Erdogan, Dursun Hakan Delibas, Hazan Tomar Bozkurt, Rukiye Tekdemir, Vefa Erbasan, Okan İmre, Memduha Aydın, Kürşat Altınbaş, Başak Karabucak, Halime Tuna Çak Esen, Sadriye Ebru Çengel Kültür, Remzi Karaokur, Songül Atasavun Uysal, Nurhan Erbil, Meltem Çiğdem Kirazlı, Tayfun Kara, Ajda Mutlu Mıhçıoğlu, Semra Yılmaz, İsmail Akaltun, Abdullah Atli, Zübeyir Can, Emine Füsun Akyüz Çim, Aslıhan Okan İbiloğlu, Nilfer Şahin, Hülya Ertekin, Zehra Başar Kocagöz, Adnan Özçetin, Ahmet Ataoğlu, Şengül Cangür, Safiye Bahar Ölmez, Neslihan Yazar, Halit Necmi Uçar, Duygu Murat, Şafak Eray, Yaşar Tanır, Hatice Altun, Mehmet Hanifi Tanyeri, Mehmet Emin Büyükokuroğlu, Pelin Tanyeri, Oguz Mutlu, Füruzan Yıldız Akar, Güner Ulak, Bekir Faruk Erden, Feyza Hatice Sevgen, Asiye Arıcı, Fethiye Kılıçaslan, Mehmet Fatih Erbay, Cengiz Darılmaz, Fikret Poyraz Çökmüş, Serra Yüzeren, Didem Sücüllüoğlu Dikici, Orkun Aydın, Pınar Ünal Aydın, Fatma Akdeniz, Siğnem Öztekin, Emine Özge Çöldür, Kuzeymen Balıkçı, Ertuğrul Köroğlu, Ömer Aydemir, Hüseyin Kara, Özgen Özçelik, Mehmet Murat Balcı, Mehmet Murat Kuloğlu, Talya Tomar, Fatma Taneli, Arzu Oran, Gülgün Yılmaz Ovalı, Gamze Yapça Kaypaklı, Özge Metin, Hakan Karaş, Halil Çetingök, Reşat İlişer, Elif Çarpar, Muzaffer Kaşer, Güneş Şayan Can, Gözde Ulaş, Ayşegül Ildız, Neslihan Emiroğlu, Emel Ada, Ayşegül Özerdem, Okan Imre, Oğuz Mutlu, Furuzan Yıldız Akar, Uğur Tekin, Ayşegül Satar, Ayşe Nur Aydın, Hatice Serpil Erermiş, Orhan Kocaman, Nihal Yurteri Çetin, Aynur Akay, Yüksel Sümeyra Karagöz, Özlem Doğan, Serenay Ülkar, Birim Günay Kılıç, Hacer Akgül Ceyhun, Esat Fahri Aydın, Tuba Ülkevan, Nilifer Gürbüzer, Hasan Cem Aykutlu, Işık Görker, Emel Özen, Evrim Aktepe, Mustafa Asım Aydın, Dudu Dilek Yavuz, Umut Karaaslan, Abdullah Karataş, Zehra Sancak, Erhan Eser, Mehmet Murat Demet, Mehmet Emrah Karadere, Ece Yazla Asafov, Halil İbrahim Ölçüm, Ayhan Algül, İbrahim Gündoğmuş, Fatih Hilmi Cetin, Hasan Ali Guler, Serhat Turkoglu, Bahar Keleş Çolpan, Elif Bayram, Funda Seher Özalp Ateş, Serap Tıraş Teber, Nagihan Saday Duman, Emel Sarı Gökten, Elif Nurgül Sungur, Melike Ceyhan Balcı Şengül, Ayşen Çetin Kardeşler, Yaşar Enli, Neslihan Kurtul, Cihan Aslan, Bahadır Konuşkan, Burçin Şener, Banu Anlar, Fatih Ünal, Bülent Devrim Akçay, Güray Koç, Sinan Yetkin, Serkan Bayad, Müge Elbir, Özge Alp Topbaş, Tuğba Kocabaş, Adem Aydın, Pelin Avcu Çelik, Deniz Argüz Çıldır, Aylin Özbek, Aybuke Tuğçe Mustan, Ayşe Sevgi Karadağ, Aysun Kalenderoğlu, Mehmet Hamdi Örüm, Murat Eren Özen, Oğuzhan Bekir Eğilmez, Dilek Bingöl Aydın, Bahri Elmas, Serhat Nasıroğlu, Engin Aydın, Öner Özdemir, Özcan Erel, Ülker Fedai, Mehmet Asoğlu, Rümeysa Yeni Elbay, Hasan Turan Karatepe, Celal Ulaşoğlu, Hamza Ayaydın, Berkan Şahin, Koray Karabekiroğlu, Abdullah Bozkurt, Miraç Barış Usta, Muazzez Aydın, Cansu Çobanoğlu, Yalçın Kahya, Dilara İnan, Ali Ercan Altınöz, Ferdi Köşger, Altan Eşsizoğlu, Mehmet Arslan, Ali Metehan Çalışkan, Duygu Göktaş, İkbal İnanlı, Saliha Çalışır, İbrahim Eren, Zeynep Baran Tatar, Erhan Kurt, Gokhan Unal, Feyza Aricioglu, Mustafa Esad Tezcan, Tuğba Kalyoncu, Fazilet Ergüvendi, Çigdem Yektaş, Recep Eroz, Gokhan Yurdakul, Mahmut Cakır, Mehmet Yalcin Tasmektepligil, Saliha Baykal, Mirac Barıs Usta, Melih Nuri Karakurt, Koray Karabekiroglu, Yasemin Yulaf, Funda Gümştaş, Sebla Gökçe, Yankı Yazgan, Doğa Sevincok, Tugba Kalyoncu, Fazilet Arkat Ergüvendi, İbrahim Yağcı, Sema Avcı, Yüksel Kıvrak, Alişan Burak Yaşar, Ceyhun Sayman, Serap Erdoğan Taycan, Yılmaz Çetinkaya, Anıl Gündüz, Hülya Tireli, Kemal Utku Yazici, Ipek Percinel Yazici, Pınar Aksu Kılıçle, Süleyman Gül, Ipek Percınel Yazici, Ayçin Darıcı Sümer, Esra Çöp, Duygu Bilgili, Müge Şahin, Gülser Şenses Dinç, Özlem Hekim, Emine Dibek Mısırlıoğlu, Funda Kurt, Zeynep Göker, Özden Üneri, Eray Atalay, İrem Yıldırım, Ali İnaltekin, Bengü Yücens, Vahap Ozan Kotan, Nihal Özkayar, Fatih Dede, Rabia Nazik Yüksel, Şenol Bayram, Zeynep Kotan, Erol Göka, Gökçe Nur Say, Merve Kalyoncu, Özlem Beğinoğlu, Bahadir Bilgin Basgoz, Semra Ince, Umut Safer, and İlker Tasci

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2018
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4. Clinical improvement and no further need of transplant after closure of PDA with transcatheter approach in an end-stage heart failure patient with hypertrabeculation

Author

Serhat Koca, Feyza Ayşenur Paç, Ajda Mutlu Mıhçıoğlu, Vedat Kavurt, and Denizhan Bağrul

Subjects
heart transplantation, noncompaction cardiomyopathy, patent ductus arteriosus., Medicine, Internal medicine, RC31-1245, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Although heart failure is managed medically most of the time, heart transplantation is still last resort for selected end-stage heart failure patients with noncompaction cardiomyopathy. Presently described for the first time is case of pediatric patient with noncompaction cardiomyopathy who was initially referred to our hospital for heart transplant but underwent PDA repair and improved clinically without need for heart transplant.

Published
2017
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6. Kawasaki Disease: 10-year Single-center Experience: Analysis of Clinical and Laboratory Findings with Treatment Approaches.

Author

Mıhçıoğlu, Ajda Mutlu and Akyol, Mehmet Bedir

Subjects
*CORONARY artery physiology, *MUCOCUTANEOUS lymph node syndrome diagnosis, *CLINICAL pathology, *IMMUNOGLOBULINS, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *MUCOCUTANEOUS lymph node syndrome, *EARLY diagnosis, *DISEASE complications, *CHILDREN
Abstract

Objective: Kawasaki disease (KD) is an acute febrile multisystem disease affecting children between 6 months and 5 years. Coronary artery involvement (CAI) is the most threatened complication of this disease. Therefore, suspicion and early diagnose of the disease is critical. Principal and additional findings are used for diagnosis accompanied by laboratory findings. We evaluated the patients who had the diagnosis and treated for KD at our center. Methods: Forty-five patients who were evaluated between 2012-2022 with the diagnosis of KD were evaluated retrospectively in our study. Intravenous immunoglobulin (IVIG) administration time, and presence of principal, and additional findings were recorded. Echocardiographic and laboratory findings were also recorded for the study. Results: Male patients were in predominace, average age was 2 years. Coronary artey involvement was present in 20% and IVIG resistance in 17.8% of the patients. Changes in the oral mucosa and lips were less frequent in the patients with CAI (+), and perineal desquamation was more frequent with IVIG resistance (p=0.039, p=0,033, respectively). All the patients were treated before 10 days (p>0.05) and a second dose of IVIG was administered to 2 patients on the 12th day. Conclusion: KD should be considered for the patients with longlasting fever, which cannot be explained with other reasons in children under 5 years of age. The relationship between the principal and additional findings with the presence of CAI and IVIG resistance were not mentioned in the literature previously. The similarity of laboratory findings in the groups suggests that laboratory findings may not always guide us about the course of the disease. Although KD may have severe complications, with timely and accurate diagnosis and treatment, the prognosis is good in general. [ABSTRACT FROM AUTHOR]

Published
2023
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7. The evaluation of right ventricular systolic function in patients with repaired Tetralogy of Fallot by conventional echocardiographic methods and speckle tracking echocardiography: Compared with the gold standard cardiac mangenetic resonance

Author

Serhat Koca, Feyza Aysenur Pac, Hasan Yigit, Ahmet Vedat Kavurt, and Ajda Mutlu Mıhçıoğlu

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Systole, Heart Ventricles, Magnetic Resonance Imaging, Cine, Speckle tracking echocardiography, Systolic function, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Cardiac magnetic resonance imaging, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Cardiac Surgical Procedures, Retrospective Studies, Tetralogy of Fallot, Ejection fraction, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Stroke Volume, Magnetic resonance imaging, Gold standard (test), medicine.disease, Cross-Sectional Studies, ROC Curve, Echocardiography, Ventricular Function, Right, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

BACKGROUND Right ventricular (RV) function is one of the important prognostic factors in patients with repaired Tetralogy of Fallot (TOF). We aimed to assess RV function by conventional echocardiography and two-dimensional speckle tracking echocardiography (2D-STE) in patients with repaired TOF. METHODS Twenty-seven (male 17) adolescents and young adult patients (mean age 22.7 ± 6.7 years) operated on for TOF and age- and gender-matched healthy controls were included. RV systolic function in both groups were evaluated by fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), RV myocardial performance index (RVMPI) and tricuspid annular peak systolic velocity by pulsed tissue Doppler (tricuspid S'), and also RV global longitudinal strain (RV GLS) obtained from STE. These results were compared with RV ejection fraction (RVEF) measured by cardiac magnetic resonance imaging (CMRI) performed within 3 months in patient group. RESULTS Systolic RVGLS values were significantly lower in patients compared to controls (-17.4 ± 3.1% vs -25.6 ± 3%). Among the echocardiographic parameters, RVGLS had the best correlation with RV EF derived from CMRI (r: -.6). By receiver operating characteristics analysis (ROC), an RV GLS cutoff value of -17.4% had 75% sensitivity and 68.4% specificity in identifying RVEF

Published
2019

8. The Relationship between Arterial Elasticity Parameters of Ascending Aorta, Abdominal Aorta and Carotid Arteries with Carotid Intima Media Thickness in Children with Bicuspid Aortic Valve.

Author

Mıhçıoğlu, Ajda Mutlu, Paç, Feyza Ayşenur, Tola, Muharrem, Kavurt, Ahmet Vedat, Koca, Serhat, and Bağrul, Denizhan

Subjects
*ABDOMINAL aorta, *CAROTID artery, *MITRAL valve, *AORTIC valve, *AORTA
Abstract

Background: Bicuspid aortic valve is a congenital cardiac malformation that affects not only the valve and ascending aorta but also the abdominal aorta and large central arteries like carotid arteries by damaging the elasticity of the vessel resulting in increased stiffness and reduced distensibility. Deterioration of aortic compliance disturbs functions of the left ventricle and triggers atherosclerosis determined with carotid intima-media thickness. The aim of this study was to assess the effect of the bicuspid aortic valve on the elastic properties of these parts of the arterial system in children. Methods: Thirty-four children with bicuspid aortic valves with normal valvular functions or mild valvular dysfunction and a control group of 34 individuals with tricuspid aortic valves were included in the study. Echocardiographic measurements of the left ventricle, ascending aorta, and ultrasonographic measurements of the abdominal aorta and carotid arteries were performed, and elasticity indexes were calculated. Results: The bicuspid aortic valve group had higher stiffness and lower distensibility in ascending aorta, abdominal aorta, and carotid arteries with higher carotid intimamedia thickness values than the tricuspid aortic valve group. Aortic valvular z scores and ascending aorta and abdominal aorta stiffness were higher in patients with bicuspid aortic valves irrespective of valvular functions than in controls. Valvular dysfunction affected stiffness in carotid arteries. Dilatation of ascending aorta increased stiffness in the abdominal aorta. Distensibility was lower in ascending aorta and left carotid artery, with increased carotid intima-media thickness independent from ascending aorta dilatation. Stiffness of abdominal aorta revealed a positive correlation with the stiffness of the ascending aorta and the carotid arteries (P < .05, for all). Conclusions: Elasticity indexes of children with bicuspid aortic valves were impaired in ascending aorta, abdominal aorta, and carotid arteries with an increase in carotid intima-media thickness. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Heart rate variability parameters in children with ventricular preexcitation

Author

Deniz Eriş, Serkan Cay, Feyza Aysenur Pac, Ajda Mutlu Mıhçıoğlu, Ozcan Ozeke, and Serhat Koca

Subjects
Male, Tachycardia, medicine.medical_specialty, Pre-Excitation Syndromes, Adolescent, Accessory pathway, 030204 cardiovascular system & hematology, Asymptomatic, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Physiology (medical), Internal medicine, medicine, Humans, Heart rate variability, 030212 general & internal medicine, Child, Retrospective Studies, medicine.diagnostic_test, Cardiac electrophysiology, business.industry, Atrial fibrillation, medicine.disease, Autonomic nervous system, Electrocardiography, Ambulatory, cardiovascular system, Cardiology, Female, medicine.symptom, Electrophysiologic Techniques, Cardiac, Cardiology and Cardiovascular Medicine, business
Abstract

INTRODUCTION The autonomic nervous system has a regulatory effect on cardiac electrophysiology and arrhythmogenesis. We aimed to assess cardiac autonomic status using heart rate variability (HRV) parameters in children with ventricular preexcitation. METHODS The electrocardiography, Holter monitoring, transesophageal electrophysiological study (TEEPS), and invasive electrophysiological study (EPS) results of ventricular preexcitation patients obtained over a 7-year period in our clinic were evaluated. According to the TEEPS results, patients' accessory pathway conduction was classified as adverse (n = 40) or nonadverse (n = 25). The HRV parameters of patients were compared according to tachycardia inducibility that assessed by TEEPS and EPS. Also, HRV parameters were compared in patients with adverse and nonadverse pathway conduction. Further, the HRV parameters of preexcitation patients were compared with those of healthy controls. RESULTS LF/HF, the best measure of sympathovagal balance, was statistically higher in patients with adverse conduction than in patients without adverse conduction and controls (P = 0.001). The LF/HF ratio was higher in ventricular preexcitation patients with inducible tachycardia than those without in EPS (P = 0.001). In addition, the LF/HF ratio was higher in symptomatic ventricular preexcitation patients than asymptomatic ones (P = 0.001). No difference in HRV parameters was found between preexcitation patients and controls. CONCLUSION Autonomic tonus in patients with ventricular preexcitation may affect accessory pathway conduction properties, tachycardia inducibility, and symptomology. The indicator of sympathovagal balance, LF/HF ratio, increased in ventricular preexcitation patients with inducible tachycardia and those that were symptomatic.

Published
2018

10. Evaluation of patients with coronary artery anomalies

Author

Feyza Aysenur Pac, Ajda Mutlu Mihçioğlu, Ahmet Vedat Kavurt, Mustafa Paç, and Serhat Koca

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Internal medicine, medicine, Cardiology, Surgery, Cardiology and Cardiovascular Medicine, business, Artery
Published
2017

12. Effects of Long-Term Use of Prescription Methylphenidate on Myocardial Performance in Children with Attention-Deficit/Hyperactivity Disorder: A Tissue Doppler Imaging Study

Author

Semra Yılmaz, İsmail Akaltun, Tayfun Kara, and Ajda Mutlu Mıhçıoğlu

Subjects
Pediatrics, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Methylphenidate, 030204 cardiovascular system & hematology, Doppler echocardiography, medicine.disease, Doppler imaging, Term (time), 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, mental disorders, Pediatrics, Perinatology and Child Health, medicine, Attention deficit hyperactivity disorder, Pharmacology (medical), 030212 general & internal medicine, Medical prescription, business, human activities, Electrocardiography, medicine.drug
Abstract

Many children diagnosed with attention-deficit/hyperactivity disorder are treated with methylphenidate (MPH). The purpose of this study was to evaluate the relationship between long-term use of osmotic-release oral system methylphenidate (OROS MPH) and cardiac functions.The study involved 116 subjects 6-18 years of age. Fifty-eight of these were in the case group and were using OROS MPH (extended-release capsules). Fifty-eight children not receiving treatment were included in the control group. Participants were also assessed using 12-channel electrocardiography (ECG), transthoracic 2D echocardiography, Doppler echocardiography, and tissue Doppler imaging (TDI). The findings obtained were compared using statistical methods.No significant differences were determined between the case and control groups in terms of systolic blood pressure and diastolic blood pressure or 12-channel ECG findings. There was also no difference in 2D and M-mode measurements among the echocardiography findings. Of the TDI parameters obtained, only E' septal values differed significantly between the case and control groups. However, this was not at such a level as to indicate cardiac function impairment.The study data showed that the echocardiographic parameters we measured resulted in no clinical difference between the children using MPH and the healthy controls. We conclude that MPH use in children does not impair cardiovascular functions at short-term follow-up.

Published
2018

14. Clinical improvement and no further need of transplant after closure of PDA with transcatheter approach in an end-stage heart failure patient with hypertrabeculation

Author

Ajda Mutlu Mıhçıoğlu, Serhat Koca, Feyza Ayşenur Paç, Vedat Kavurt, and Denizhan Bagrul

Subjects
medicine.medical_specialty, Noncompaction cardiomyopathy, lcsh:Internal medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, Cardiac Catheterization, medicine.medical_treatment, lcsh:Medicine, heart transplantation, Transcatheter approach, Internal medicine, medicine, Humans, Closure (psychology), lcsh:RC31-1245, Child, Ductus Arteriosus, Patent, Heart transplantation, Heart Failure, business.industry, lcsh:R, noncompaction cardiomyopathy, medicine.disease, patent ductus arteriosus, Pediatric patient, lcsh:RC666-701, Heart failure, Cardiology, End stage heart failure, Cardiology and Cardiovascular Medicine, business
Abstract

Although heart failure is managed medically most of the time, heart transplantation is still last resort for selected end-stage heart failure patients with noncompaction cardiomyopathy. Presently described for the first time is case of pediatric patient with noncompaction cardiomyopathy who was initially referred to our hospital for heart transplant but underwent PDA repair and improved clinically without need for heart transplant.

Published
2017

15. Oral Research Presentations

Author

Gürbüz, Hatice Gözde Akkın, primary, Turhan, Levent, additional, Şendil, Nilgun, additional, Kaşıkçı, Halim Ömer, additional, Salepçi, Banu, additional, Ipekcioglu, Derya, additional, Karcı, Canan Kuygun, additional, Ray, Perihan Çam, additional, Tahiroğlu, Ayşegül Yolga, additional, Avcı, Ayşe, additional, Çelik, Gonca Gül, additional, Cekin, Necmi, additional, Evliyaoğlu, Nurdan, additional, Alkanat, Mehmet, additional, Özdemir, Hafize, additional, Akgün, Egemen, additional, Demirkol, Mehmet Emin, additional, Tamam, Lut, additional, Esnafoglu, Erman, additional, Sevinçok, Doğa, additional, Memiş, Çağdaş Öykü, additional, Doğan, Bilge, additional, Çakaloz, Burcu, additional, Kutlu, Ayşe, additional, Sevinçok, Levent, additional, Dikmen, Sema Nur Türkoğlu, additional, Şafak, Yasir, additional, Gökçer Tulacı, Rıza, additional, Özdemir, İlker, additional, Baykara, Sema, additional, Alban, Kübra, additional, Aydın, Nazan, additional, Aytaç, Hasan Mervan, additional, Yılmaz, Doğan, additional, Aydın, Pınar Çetinay, additional, Yalçın, Gökşen Yüksel, additional, Canbay, Cana, additional, Terzioğlu, Merve, additional, Özer, Aysel, additional, Altintas, Ebru, additional, Kütük, Meryem Özlem, additional, Tufan, Ali Evren, additional, Bağ, Harika Gözükara, additional, Şenormancı, Güliz, additional, Güçlü, Oya, additional, Çelik, Cemil, additional, Bolu, Abdullah, additional, Öznur, Taner, additional, Aydın, Mehmet Sinan, additional, Tokgöz, Yusuf, additional, Uzun, Özcan, additional, Gıca, Sakır, additional, Poyraz, Burç Çağrı, additional, Fidan, Yağmur Sever, additional, Güleç, Hüseyin, additional, Akça, Erdoğdu, additional, Yıldız, Mesut, additional, Akça, Zeynep Nur Demirok, additional, Öztürk, Yusuf, additional, Özyurt, Gonca, additional, Özdel, Kadir, additional, Elboga, Gulcin, additional, Ozyurek, Muhammet Berkay, additional, Akgün, Abdullah, additional, Coşkun, Ali, additional, Bilgiç, Ayhan, additional, Sivri, Rukiye Çolak, additional, Kılınç, İbrahim, 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additional, Karaokur, Remzi, additional, Uysal, Songül Atasavun, additional, Erbil, Nurhan, additional, Kirazlı, Meltem Çiğdem, additional, Kara, Tayfun, additional, Mıhçıoğlu, Ajda Mutlu, additional, Yılmaz, Semra, additional, Akaltun, İsmail, additional, Atli, Abdullah, additional, Can, Zübeyir, additional, Çim, Emine Füsun Akyüz, additional, İbiloğlu, Aslıhan Okan, additional, Şahin, Nilfer, additional, Ertekin, Hülya, additional, Kocagöz, Zehra Başar, additional, Özçetin, Adnan, additional, Ataoğlu, Ahmet, additional, Cangür, Şengül, additional, Ölmez, Safiye Bahar, additional, Yazar, Neslihan, additional, Uçar, Halit Necmi, additional, Murat, Duygu, additional, Eray, Şafak, additional, Tanır, Yaşar, additional, Altun, Hatice, additional, Tanyeri, Mehmet Hanifi, additional, Büyükokuroğlu, Mehmet Emin, additional, Tanyeri, Pelin, additional, Mutlu, Oguz, additional, Akar, Füruzan Yıldız, additional, Ulak, Güner, additional, Erden, Bekir Faruk, additional, Sevgen, Feyza Hatice, additional, Arıcı, Asiye, additional, Kılıçaslan, Fethiye, additional, Erbay, Mehmet Fatih, additional, Darılmaz, Cengiz, additional, Çökmüş, Fikret Poyraz, additional, Yüzeren, Serra, additional, Dikici, Didem Sücüllüoğlu, additional, Aydın, Orkun, additional, Aydın, Pınar Ünal, additional, Akdeniz, Fatma, additional, Öztekin, Siğnem, additional, Çöldür, Emine Özge, additional, Balıkçı, Kuzeymen, additional, Köroğlu, Ertuğrul, additional, Aydemir, Ömer, additional, Kara, Hüseyin, additional, Özçelik, Özgen, additional, Balcı, Mehmet Murat, additional, Kuloğlu, Mehmet Murat, additional, Tomar, Talya, additional, Taneli, Fatma, additional, Oran, Arzu, additional, Ovalı, Gülgün Yılmaz, additional, Kaypaklı, Gamze Yapça, additional, Metin, Özge, additional, Karaş, Hakan, additional, Çetingök, Halil, additional, İlişer, Reşat, additional, Çarpar, Elif, additional, Kaşer, Muzaffer, additional, Can, Güneş Şayan, additional, Ulaş, Gözde, additional, Ildız, Ayşegül, additional, Emiroğlu, 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Halil İbrahim, additional, Algül, Ayhan, additional, Gündoğmuş, İbrahim, additional, Cetin, Fatih Hilmi, additional, Guler, Hasan Ali, additional, Turkoglu, Serhat, additional, Çolpan, Bahar Keleş, additional, Bayram, Elif, additional, Ateş, Funda Seher Özalp, additional, Teber, Serap Tıraş, additional, Duman, Nagihan Saday, additional, Gökten, Emel Sarı, additional, Sungur, Elif Nurgül, additional, Şengül, Melike Ceyhan Balcı, additional, Kardeşler, Ayşen Çetin, additional, Enli, Yaşar, additional, Kurtul, Neslihan, additional, Aslan, Cihan, additional, Konuşkan, Bahadır, additional, Şener, Burçin, additional, Anlar, Banu, additional, Ünal, Fatih, additional, Akçay, Bülent Devrim, additional, Koç, Güray, additional, Yetkin, Sinan, additional, Bayad, Serkan, additional, Elbir, Müge, additional, Topbaş, Özge Alp, additional, Kocabaş, Tuğba, additional, Aydın, Adem, additional, Avcu Çelik, Pelin, additional, Çıldır, Deniz Argüz, additional, Özbek, Aylin, additional, Mustan, Aybuke Tuğçe, 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Çalışır, Saliha, additional, Eren, İbrahim, additional, Tatar, Zeynep Baran, additional, Kurt, Erhan, additional, Unal, Gokhan, additional, Aricioglu, Feyza, additional, Tezcan, Mustafa Esad, additional, Kalyoncu, Tuğba, additional, Ergüvendi, Fazilet, additional, Yektaş, Çigdem, additional, Eroz, Recep, additional, Yurdakul, Gokhan, additional, Cakır, Mahmut, additional, Tasmektepligil, Mehmet Yalcin, additional, Baykal, Saliha, additional, Usta, Mirac Barıs, additional, Karakurt, Melih Nuri, additional, Karabekiroglu, Koray, additional, Yulaf, Yasemin, additional, Gümştaş, Funda, additional, Gökçe, Sebla, additional, Yazgan, Yankı, additional, Sevincok, Doğa, additional, Kalyoncu, Tugba, additional, Ergüvendi, Fazilet Arkat, additional, Yağcı, İbrahim, additional, Avcı, Sema, additional, Kıvrak, Yüksel, additional, Yaşar, Alişan Burak, additional, Sayman, Ceyhun, additional, Taycan, Serap Erdoğan, additional, Çetinkaya, Yılmaz, additional, Gündüz, Anıl, additional, Tireli, Hülya, additional, Yazici, Kemal Utku, additional, Yazici, Ipek Percinel, additional, Kılıçle, Pınar Aksu, additional, Gül, Süleyman, additional, Yazici, Ipek Percınel, additional, Sümer, Ayçin Darıcı, additional, Çöp, Esra, additional, Bilgili, Duygu, additional, Şahin, Müge, additional, Dinç, Gülser Şenses, additional, Hekim, Özlem, additional, Mısırlıoğlu, Emine Dibek, additional, Kurt, Funda, additional, Göker, Zeynep, additional, Üneri, Özden, additional, Atalay, Eray, additional, Yıldırım, İrem, additional, İnaltekin, Ali, additional, Yücens, Bengü, additional, Kotan, Vahap Ozan, additional, Özkayar, Nihal, additional, Dede, Fatih, additional, Yüksel, Rabia Nazik, additional, Bayram, Şenol, additional, Kotan, Zeynep, additional, Göka, Erol, additional, Say, Gökçe Nur, additional, Kalyoncu, Merve, additional, Beğinoğlu, Özlem, additional, Basgoz, Bahadir Bilgin, additional, Ince, Semra, additional, Safer, Umut, additional, and Tasci, İlker, additional

Published
2018
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16. A Review of the Principles of Radiological Assessment of Skeletal Dysplasias

Author

Gül Yeşiltepe Mutlu, Şükrü Hatun, Ajda Mutlu, Elif Ozsu, and Filiz Mine Çizmecioğlu

Subjects
medicine.medical_specialty, Type 1 diabetes, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Rickets, medicine.disease, vitamin D deficiency, Endocrinology, Diabetes mellitus, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Vitamin D and neurology, Secondary hyperparathyroidism, business, Prospective cohort study
Abstract

Objective: To investigate the frequency and effects of vitamin D deficiency in children with type 1 diabetes (T1D) in a region which is known to have a high rate of vitamin D deficiency among adolescents. Methods: In this prospective cross-sectional study, 120 children and adolescents with T1D (55 girls and 65 boys) aged 3-20 years were evaluated. Serum 25-hydroxyvitamin D [25(OH)D], parathormone (PTH), and alkaline phosphatase (ALP) levels were measured. Hemoglobin A1c levels and daily insulin requirement were also evaluated. Classification of vitamin D status was made according to the American Academy of Pediatrics (AAP)/LWEPS’s recommendations. The patients were divided into 2 groups according to their vitamin D status and also according to the season of the year in which 25(OH)D sampling was done. Results: Serum 25(OH)D levels revealed vitamin D deficiency or insufficiency in 38% of the patients. Higher PTH levels were found in the patient group whose mean 25(OH)D level was 20 ng/mL (p

Published
2011

19. Transesophageal and invasive electrophysiologic evaluation in children with Wolff-Parkinson-White pattern

Author

Ajda Mutlu Mıhçıoğlu, Serkan Cay, Feyza Ayşenur Paç, Ahmet Vedat Kavurt, Dursun Aras, Serkan Topaloglu, and Serhat Koca

Subjects
Male, medicine.medical_specialty, Adolescent, Population, Accessory pathway, 030204 cardiovascular system & hematology, Risk Assessment, Sensitivity and Specificity, 03 medical and health sciences, Electrophysiology study, Electrocardiography, 0302 clinical medicine, Interquartile range, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, education, Child, education.field_of_study, medicine.diagnostic_test, business.industry, Effective refractory period, General Medicine, Wolff-Parkinson-White pattern, medicine.disease, Surgery, Risk stratification, Cardiology, Electrocardiography, Ambulatory, Exercise Test, Female, Wolff-Parkinson-White Syndrome, Supraventricular tachycardia, Cardiology and Cardiovascular Medicine, business, Electrophysiologic Techniques, Cardiac
Abstract

Background Risk stratification for Wolff-Parkinson-White (WPW) pattern either by noninvasive or invasive tests is important to determine whether an ablation is necessary or not. The aim was to compare noninvasive tests and invasive studies in a pediatric WPW population. Methods A total of 71 WPW patients (median age 14 years [interquartile range, 11-16 years]; 43 male) underwent Holter monitoring, exercise stress test (EST), and transesophageal electrophysiological study (TEEPS). In the case of a ≤270-ms effective refractory period of accessory pathway or induction of supraventricular tachycardia using TEEPS, patients were classified as high risk and underwent invasive electrophysiological study (EPS). Results Nine of 23 patients with low risk by Holter and eight of 26 patients with low risk by EST had high risk in TEEPS. Risky TEEPS results were detected in 42 of 71 patients and those patients underwent EPS. High-risk characteristic in EPS was detected in seven of nine patients with low risk by Holter and in seven of eight with low risk by EST. Both tests yielded moderate specificity (52-69%) and negative predictive value (61-69%) according to TEEPS. Conclusion Holter and EST have low predictive value in WPW risk stratification. However, TEEPS and EPS are extremely valuable in WPW risk stratification. TEEPS may reveal important and useful results for WPW risk determination, especially in small children not having undergone EPS in order to avoid its complications.

Published
2015

20. ALCAPA Sendromunda Anestezi Yönetimi ve İntraoperatif Transözofageal Ekokardiyografi Kullanımı.

Author

Şaylan, Alev, Karadeniz, Ümit, Paç, Feyza Ayşenur, Mıhçıoğlu, Ajda Mutlu, Kavurt, Ahmet Vedat, Taşoğlu, İrfan, and Paç, Mustafa

Subjects
PULMONARY artery, TRANSESOPHAGEAL echocardiography, CORONARY arteries, AORTA, ANESTHESIA, SUPERIOR mesenteric artery syndrome
Abstract

Copyright of Journal of the Society of Thoracic Carido-Vascular Anaesthesia & Intensive Care is the property of Gogus Kalp Damar Anestezi ve Yogun Bakim Dernegi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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23. A case of Jarcho-Levin syndrome associated with bilateral cystic renal disease and wilms tumor: MR imaging findings

Author

Funda Corapcioglu, Ajda Mutlu, A. Sıtkı Ozdamar, Gür Akansel, Nagihan Inan, and Kürşat Yildiz

Subjects
Pathology, medicine.medical_specialty, Renal cortical cysts, Adolescent, Disease, Wilms Tumor, Antineoplastic Combined Chemotherapy Protocols, Medicine, Humans, Jarcho-Levin syndrome, Thoracic deformity, business.industry, Dysostoses, Wilms' tumor, Hematology, Syndrome, Kidney Diseases, Cystic, medicine.disease, Mr imaging, Magnetic Resonance Imaging, Spondylocostal dysostosis, Kidney Neoplasms, Radiography, Oncology, Pediatrics, Perinatology and Child Health, Female, business, Congenital disorder
Abstract

Jarcho-Levin syndrome (JLS) is a congenital disorder characterized by a variety of vertebral and costal anomalies that result in thoracic deformity. Hitherto, a plethora of associated anomalies have been described in several reports. In this report, the authors describe a case of JLS who has Wilms tumor and bilateral cystic renal disease. To the authors’ knowledge, there is only a single case of JLS who presented with multiple renal cortical cysts, but none with an associated Wilms tumor in the literature. Additional anomalies seen in the present case that are related with this syndrome are also discussed.

Published
2009

24. Clinical improvement and no further need of transplant after closure of PDA with transcatheter approach in an end-stage heart failure patient with hypertrabeculation.

Author

Koca, Serhat, Paç, Feyza Ayşenur, Mıhçıoğlu, Ajda Mutlu, Kavurt, Vedat, and Bağrul, Denizhan

Abstract

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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