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1. Aspectos técnicos en la infiltración caudal guiada por tomografía computarizada

Author

Muntané Sánchez, A., Fontes Caramé, D., Mayoral Rojals, V., and Aja Rodríguez, L.

Subjects
Tomografía computarizada, Epidural, Tomography computed, Caudal, Analgesia
Abstract

Introducción: La infiltración epidural caudal constituye en la actualidad una de las técnicas de analgesia regional que se utiliza con más frecuencia para el dolor crónico lumbar. Nuestro objetivo principal a alcanzar en esta exposición es poner de relieve una nueva técnica para realizar esta intervención que resulta más sencilla y menos agresiva para el paciente que la utilizada clásicamente. Material y métodos: Esta técnica se ha realizado en 13 pacientes (2 varones y 11 mujeres), con edades comprendidas entre los 33 y los 84 años. Todos los pacientes tenían dolor lumbar crónico. Para realizarla se ha utilizado un equipo de tomografía computarizada (TC) General Electric Light Speed 16, una aguja de punción lumbar de 22G y las medidas estériles adecuadas. La TC es una herramienta que facilita enormemente la visualización del ligamento sacrocoxígeo. Una vez introducida la aguja y comprobado mediante TC que se encuentre en el interior del canal raquídeo caudal, se procede a girar el bisel en dirección craneal con el objetivo de que el fármaco administrada salga por el orificio de la aguja hacia el canal neural. Discusión: La técnica más frecuente en la práctica de la infiltración epidural caudal se realiza habitualmente con el paciente en decúbito prono, con la cabeza girada sobre un lado utilizando un arco de rayos X. Mediante la técnica que mostramos, la punción es menos agresiva, más rápida y hay menos posibilidades de complicaciones. El riesgo de perforar el saco dural es prácticamente inexistente, así como de producir hematomas o infecciones, debido a que la manipulación con la aguja es mucho menor y se ciñe únicamente a una punción directa. En el 100% de los casos en que se ha practicado nuestra técnica, la difusión de la medicación administrada se ha realizado en dirección craneal, lo cual se ha verificado debido al contraste que se ha añadido a la mezcla farmacológica. Introduction: Caudal epidural infiltration is currently one of the most used regional analgesia techniques for control of chronic low pack pain. Our primary objective in this presentation is to highlight a new technique for performing this intervention which is simpler and less aggressive for the patient than that classically used. Material and methods: This new technique has been used on 13 patients (2 males and 11 females) between 33 and 84 years. All patients had chronic lumbar pain. A General Electric Light Speed 16 CT scanner, a 22G lumbar puncture needle and appropriate sterile measures, were used to perform the technique. The CT scanner is a tool that makes it much easier to visualise the sacrococcygeal ligament. After the needle is introduced, and checked using CT, into the caudal spinal canal, the bevel is turned in the cranial direction in order that the medication administered comes out of the needle orifice towards the neural canal. Discussion: The most common technique for performing caudal epidural infiltration is usually done in the prone position with the head turned to one side using an X-ray arch. Using this technique we show that the puncture is less aggressive, quicker and with fewer possibilities of complications. The risk of perforating the dural sac is practically non-existent. There is also less risk of producing haematomas or infections, due to there being much less manipulation of the needle and only involves a direct puncture. In the 100% of cases on which our technique has been performed, the diffusion of the administered medication has been made in the cranial direction, which has been verified using contrast added to the pharmacological mixture.

Published
2010

2. Tratamiento mediante punción guiada por TC de un meningocele intrasacro oculto doloroso: Caso clínico y revisión de la literatura

Author

Muntané Sánchez, Amadeo, Mayoral Rojals, Víctor, Pérez Rubiralta, M., Velasco Díaz, Y., Mora Montoya, P., Aja Rodríguez, L., Aixut Lorenzo, S., Muntané Sánchez, Amadeo, Mayoral Rojals, Víctor, Pérez Rubiralta, M., Velasco Díaz, Y., Mora Montoya, P., Aja Rodríguez, L., and Aixut Lorenzo, S.

Abstract

Case reports: We report a 43-year old patient with a history of disabling pain sacrum 8/10 on the VAS of 8 months. No sensory disturbances were noted or loss of bowel control. Consultation conducted in multiple hospitals. She underwent a computed tomography (CT) lumbar that highlighted a hemangioma in L5, a magnetic resonance imaging (MRI) of the pelvis which showed muscle breakdown grade I of the left maximus gluteus, and a cystic lesion in the sacrum, which was interpreted as a Tarlov cyst. She received analgesic and anti-inflammatory treatment with no improvement. She also goes through two facet blocks and even a lock in the left piriformis, all without results. In our center we practised a lumbosacral MRI which highlighted a cystic lesion localized in central and right lateral sacral spinal canal at the level of S2-S3 transition. It was high signal on T2 and low signal on T1. Discussion: According to Nabors classification, this lesion corresponds to a hidden intrasacro meningocele. The hidden intrasacro meningocele (extradural meningeal cyst type classification LB Nabors) is a rare entity that usually develops between the third and fourth decade of life, as an insidious clinical lower extremity pain, with or without radicular symptoms, bowel dysfunction and sensory disturbances. The usual treatment of these lesions is surgical intervention. In our case puncture and evacuation guided by CT of the sacral cyst was performed, yielding about 2 cc of a sero-hematic fluid. The postoperative course was a remarkable improvement, and the sacral pain happened to be 3/10 on the VAS. In the literature that we have reviewed, this is the first case in which a hidden painful intrasacro meningocele is evacuated by CT-guided puncture., Casos clínicos: Presentamos una paciente de 43 años con historia clínica de dolor sacro incapacitante 8/10 en la escala de EVA de 8 meses de evolución. No se apreciaban alteraciones sensitivas ni pérdida del control de esfínteres. Realizó consulta en múltiples hospitales. Se le practicaron una tomografía computadorizada (TC) lumbar que puso de relieve un hemangioma en L5, una resonancia magnética (RM) de pelvis en la que se evidenció rotura muscular grado I del glúteo mayor izquierdo y una lesión quística en el sacro que se interpretó como quiste de Tarlov. Recibió tratamiento analgésico y antiinflamatorio sin mejoría. Se le realizaron dos bloqueos facetarios e incluso un bloqueo del músculo piriforme izquierdo, todo ello sin resultados. En nuestro centro se practicó una RM lumbo-sacra que puso de relieve la lesión quística de localización central y lateral derecha en canal espinal sacro a la altura de la transición S2-S3. Era de alta señal en T2 y de baja señal en T1. Según la clasificación de Nabors correspondía a un meningocele intrasacro oculto. Discusión: El meningocele intrasacro oculto (quiste meníngeo extradural tipo lB de la clasificación de Nabors) es una entidad poco frecuente que se presenta generalmente entre la tercera y cuarta década de la vida, como un cuadro clínico insidioso de dolor en extremidades inferiores, con o sin síntomas radiculares, disfunción de esfínteres y alteraciones sensitivas. El tratamiento habitual de este tipo de lesiones es la intervención quirúrgica. En nuestro caso se realizó punción y evacuación del quiste sacro guiado por TC obteniéndose unos 2 cc de un líquido sero-hemático. La evolución posterior fue de mejoría notable del dolor sacro que paso a ser de 3/10 en la escala de EVA. En la revisión de la literatura que hemos efectuado este es el primer caso en que se trata un meningocele intrasacro oculto doloroso mediante punción evacuadora guiada por TC.

Published
2014

4. Aspectos técnicos en la infiltración caudal guiada por tomografía computarizada

Author

Muntané Sánchez, Amadeo, Fontes Carame, Daniel, Aja Rodríguez, L., Mayoral Rojals, Víctor, Muntané Sánchez, Amadeo, Fontes Carame, Daniel, Aja Rodríguez, L., and Mayoral Rojals, Víctor

Abstract

Introduction: Caudal epidural infiltration is currently one of the most used regional analgesia techniques for control of chronic low pack pain. Our primary objective in this presentation is to highlight a new technique for performing this intervention which is simpler and less aggressive for the patient than that classically used. Material and methods: This new technique has been used on 13 patients (2 males and 11 females) between 33 and 84 years. All patients had chronic lumbar pain. A General Electric Light Speed 16 CT scanner, a 22G lumbar puncture needle and appropriate sterile measures, were used to perform the technique. The CT scanner is a tool that makes it much easier to visualise the sacrococcygeal ligament. After the needle is introduced, and checked using CT, into the caudal spinal canal, the bevel is turned in the cranial direction in order that the medication administered comes out of the needle orifice towards the neural canal. Discussion: The most common technique for performing caudal epidural infiltration is usually done in the prone position with the head turned to one side using an X-ray arch. Using this technique we show that the puncture is less aggressive, quicker and with fewer possibilities of complications. The risk of perforating the dural sac is practically non-existent. There is also less risk of producing haematomas or infections, due to there being much less manipulation of the needle and only involves a direct puncture. In the 100% of cases on which our technique has been performed, the diffusion of the administered medication has been made in the cranial direction, which has been verified using contrast added to the pharmacological mixture., Introducción: La infiltración epidural caudal constituye en la actualidad una de las técnicas de analgesia regional que se utiliza con más frecuencia para el dolor crónico lumbar. Nuestro objetivo principal a alcanzar en esta exposición es poner de relieve una nueva técnica para realizar esta intervención que resulta más sencilla y menos agresiva para el paciente que la utilizada clásicamente. Material y métodos: Esta técnica se ha realizado en 13 pacientes (2 varones y 11 mujeres), con edades comprendidas entre los 33 y los 84 años. Todos los pacientes tenían dolor lumbar crónico. Para realizarla se ha utilizado un equipo de tomografía computarizada (TC) General Electric Light Speed 16, una aguja de punción lumbar de 22G y las medidas estériles adecuadas. La TC es una herramienta que facilita enormemente la visualización del ligamento sacrocoxígeo. Una vez introducida la aguja y comprobado mediante TC que se encuentre en el interior del canal raquídeo caudal, se procede a girar el bisel en dirección craneal con el objetivo de que el fármaco administrada salga por el orificio de la aguja hacia el canal neural. Discusión: La técnica más frecuente en la práctica de la infiltración epidural caudal se realiza habitualmente con el paciente en decúbito prono, con la cabeza girada sobre un lado utilizando un arco de rayos X. Mediante la técnica que mostramos, la punción es menos agresiva, más rápida y hay menos posibilidades de complicaciones. El riesgo de perforar el saco dural es prácticamente inexistente, así como de producir hematomas o infecciones, debido a que la manipulación con la aguja es mucho menor y se ciñe únicamente a una punción directa. En el 100% de los casos en que se ha practicado nuestra técnica, la difusión de la medicación administrada se ha realizado en dirección craneal, lo cual se ha verificado debido al contraste que se ha añadido a la mezcla farmacológica.

Published
2010

6. Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke.

Author

Boers AMM, Jansen IGH, Brown S, Lingsma HF, Beenen LFM, Devlin TG, Román LS, Heo JH, Ribó M, Almekhlafi MA, Liebeskind DS, Teitelbaum J, Cuadras P, du Mesnil de Rochemont R, Beaumont M, Brown MM, Yoo AJ, Donnan GA, Mas JL, Oppenheim C, Dowling RJ, Moulin T, Agrinier N, Lopes DK, Aja Rodríguez L, Compagne KCJ, Al-Ajlan FS, Madigan J, Albers GW, Soize S, Blasco J, Davis SM, Nogueira RG, Dávalos A, Menon BK, van der Lugt A, Muir KW, Roos YBWEM, White P, Mitchell PJ, Demchuk AM, van Zwam WH, Jovin TG, van Oostenbrugge RJ, Dippel DWJ, Campbell BCV, Guillemin F, Bracard S, Hill MD, Goyal M, Marquering HA, and Majoie CBLM

Subjects
Aged, Brain Ischemia diagnostic imaging, Brain Ischemia physiopathology, Cerebral Infarction diagnostic imaging, Cerebral Infarction pathology, Cerebral Infarction physiopathology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multicenter Studies as Topic statistics & numerical data, Randomized Controlled Trials as Topic statistics & numerical data, Stroke diagnostic imaging, Stroke physiopathology, Brain Ischemia pathology, Brain Ischemia therapy, Endovascular Procedures statistics & numerical data, Outcome Assessment, Health Care statistics & numerical data, Stroke pathology, Stroke therapy
Abstract

Importance: The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke., Objective: To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke., Design, Setting, and Participants: Patient data from 7 randomized multicenter trials were pooled. These trials were conducted between December 2010 and April 2015 and included 1764 patients randomly assigned to receive either EVT or standard care (control). Follow-up infarct volume was assessed on computed tomography or magnetic resonance imaging after stroke onset. Mediation analysis was performed to examine the potential causal chain in which FIV may mediate the relationship between EVT and functional outcome. A total of 1690 patients met the inclusion criteria. Twenty-five additional patients were excluded, resulting in a total of 1665 patients, including 821 (49.3%) in the EVT group and 844 (50.7%) in the control group. Data were analyzed from January to June 2017., Main Outcome and Measure: The 90-day functional outcome via the modified Rankin Scale (mRS)., Results: Among 1665 patients, the median (interquartile range [IQR]) age was 68 (57-76) years, and 781 (46.9%) were female. The median (IQR) time to FIV measurement was 30 (24-237) hours. The median (IQR) FIV was 41 (14-120) mL. Patients in the EVT group had significantly smaller FIVs compared with patients in the control group (median [IQR] FIV, 33 [11-99] vs 51 [18-134] mL; P = .007) and lower mRS scores at 90 days (median [IQR] score, 3 [1-4] vs 4 [2-5]). Follow-up infarct volume was a predictor of functional outcome (adjusted common odds ratio, 0.46; 95% CI, 0.39-0.54; P < .001). Follow-up infarct volume partially mediated the relationship between treatment type with mRS score, as EVT was still significantly associated with functional outcome after adjustment for FIV (adjusted common odds ratio, 2.22; 95% CI, 1.52-3.21; P < .001). Treatment-reduced FIV explained 12% (95% CI, 1-19) of the relationship between EVT and functional outcome., Conclusions and Relevance: In this analysis, follow-up infarct volume predicted functional outcome; however, a reduced infarct volume after treatment with EVT only explained 12% of the treatment benefit. Follow-up infarct volume as measured on computed tomography and magnetic resonance imaging is not a valid proxy for estimating treatment effect in phase II and III trials of acute ischemic stroke.

Published
2019
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7. Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials.

Author

Boers AMM, Jansen IGH, Beenen LFM, Devlin TG, San Roman L, Heo JH, Ribó M, Brown S, Almekhlafi MA, Liebeskind DS, Teitelbaum J, Lingsma HF, van Zwam WH, Cuadras P, du Mesnil de Rochemont R, Beaumont M, Brown MM, Yoo AJ, van Oostenbrugge RJ, Menon BK, Donnan GA, Mas JL, Roos YBWEM, Oppenheim C, van der Lugt A, Dowling RJ, Hill MD, Davalos A, Moulin T, Agrinier N, Demchuk AM, Lopes DK, Aja Rodríguez L, Dippel DWJ, Campbell BCV, Mitchell PJ, Al-Ajlan FS, Jovin TG, Madigan J, Albers GW, Soize S, Guillemin F, Reddy VK, Bracard S, Blasco J, Muir KW, Nogueira RG, White PM, Goyal M, Davis SM, Marquering HA, and Majoie CBLM

Subjects
Aged, Brain Ischemia therapy, Cerebral Infarction diagnostic imaging, Cerebral Infarction therapy, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging methods, Middle Aged, Stroke therapy, Time Factors, Tomography, X-Ray Computed methods, Treatment Outcome, Brain Ischemia diagnostic imaging, Randomized Controlled Trials as Topic methods, Recovery of Function physiology, Stroke diagnostic imaging
Abstract

Background: Follow-up infarct volume (FIV) has been recommended as an early indicator of treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal imaging approach for FIV measurement., Objective: To examine the association of FIV with 90-day modified Rankin Scale (mRS) score and investigate its dependency on acquisition time and modality., Methods: Data of seven trials were pooled. FIV was assessed on follow-up (12 hours to 2 weeks) CT or MRI. Infarct location was defined as laterality and involvement of the Alberta Stroke Program Early CT Score regions. Relative quality and strength of multivariable regression models of the association between FIV and functional outcome were assessed. Dependency of imaging modality and acquisition time (≤48 hours vs >48 hours) was evaluated., Results: Of 1665 included patients, 83% were imaged with CT. Median FIV was 41 mL (IQR 14-120). A large FIV was associated with worse functional outcome (OR=0.88(95% CI 0.87 to 0.89) per 10 mL) in adjusted analysis. A model including FIV, location, and hemorrhage type best predicted mRS score. FIV of ≥133 mL was highly specific for unfavorable outcome. FIV was equally strongly associated with mRS score for assessment on CT and MRI, even though large differences in volume were present (48 mL (IQR 15-131) vs 22 mL (IQR 8-71), respectively). Associations of both early and late FIV assessments with outcome were similar in strength (ρ=0.60(95% CI 0.56 to 0.64) and ρ=0.55(95% CI 0.50 to 0.60), respectively)., Conclusions: In patients with an acute ischemic stroke due to a proximal intracranial occlusion of the anterior circulation, FIV is a strong independent predictor of functional outcome and can be assessed before 48 hours, oneither CT or MRI., Competing Interests: Competing interests: MG reports grants from Covidien, personal fees from Covidien, during the conduct of the study; MG has a patent for diagnosing strokes (PCT/ CA2013/000761) licensed to GE Healthcare. BKM reports membership of the Steering and Executive Committee, ESCAPE trial that received support from Covidien Inc., Site Principal Investigator, SOCRATES Trial, sponsored by Astra Zeneca, honoraria from Penumbra Inc., a provisional patent 62/086077 for triaging systems in ischemic stroke, research funding from CIHR, HSFC, AIHS, HBI and the Faculty of Medicine, University of Calgary and board membership of QuikFlo Health Inc. WHvZ reports Honoraria; Modest; Stryker (paid to Institution). DWJD reports honoraria; Modest; Stryker (paid to Institution). PJM reports unrestricted grant funding for the EXTEND-IA trial to the Florey Institute of Neuroscience and Mental Health from Covidien (Medtronic), has served as an unpaid consultant to Codman Johnson and Johnson, his organization has received unrestricted research funding and grants from Codman Johnson and Johnson, Medtronic, and Stryker. AMD reports grant support and personal fees from Covidien (Medtronic). AD reports consultant/Advisory Board; Modest; Medtronic Neurovascular (Steering Committee STAR). CBLMM reports speakers' Bureau; Modest; Stryker (paid to institution). GAD reports grants from the Australian National Health & Medical Research Council, non-financial support from, and has served on advisory boards for Boehringer Ingelheim, Astra Zeneca, Bristol Meyers-Squibb, Merck Sharp & Dohme outside the submitted work. BCVC reports research support from the National Health and Medical Research Council of Australia (GNT1043242, GNT1035688), Royal Australasian College of Physicians, Royal Melbourne Hospital Foundation, National Heart Foundation, National Stroke Foundation of Australia and unrestricted grant funding for the EXTEND-IA trial to the Florey Institute of Neuroscience and Mental Health from Covidien (Medtronic). MDH reports unrestricted grant funding for the ESCAPE trial to University of Calgary from Covidien (Medtronic), and active/in-kind support consortium of public/charitable sources (Heart & Stroke Foundation, Alberta Innovates Health Solutions, Alberta Health Services) and the University of Calgary (Hotchkiss Brain Institute, Departments of Clinical Neurosciences and Radiology, and Calgary Stroke Program); personal fees from Merck, non-financial support from Hoffmann-La Roche Canada Ltd, outside the submitted work; MDH has a patent Systems and Methods for Assisting in Decision-Making and Triaging for Acute Stroke Patients pending to US Patent office Number: 62/086,077 and owns stock in Calgary Scientific Incorporated, a company that focuses on medical imaging software. AMMB and HAM own stock in Nico.lab, a company that focuses on medical imaging software. TGJ has consulted for Codman Neurovascular and Neuravi, holds stock in Silk Road and Blockade; has acted as an unpaid consultant to Stryker as PI of the DAWN trial and served as an unpaid member of a Medtronic Advisory Board. SMD reports lecture fees from Covidien (Medtronic). ScB acts as consultant for Medtronic. GWA reports equity and consulting for iSchemaView (imaging software) and consulting for Medtronic., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)

Published
2018
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