11 results on '"Aiyepada, John"'
Search Results
2. Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria
- Author
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Olawoye, Idowu B., Oluniyi, Paul E., Oguzie, Judith U., Uwanibe, Jessica N., Kayode, Tolulope A., Olumade, Testimony J., Ajogbasile, Fehintola V., Parker, Edyth, Eromon, Philomena E., Abechi, Priscilla, Sobajo, Tope A., Ugwu, Chinedu A., George, Uwem E., Ayoade, Femi, Akano, Kazeem, Oyejide, Nicholas E., Nosamiefan, Iguosadolo, Fred-Akintunwa, Iyanuoluwa, Adedotun-Sulaiman, Kemi, Brimmo, Farida B., Adegboyega, Babatunde B., Philip, Courage, Adeleke, Richard A., Chukwu, Grace C., Ahmed, Muhammad I., Ope-Ewe, Oludayo O., Otitoola, Shobi G., Ogunsanya, Olusola A., Saibu, Mudasiru F., Sijuwola, Ayotunde E., Ezekiel, Grace O., John, Oluwagboadurami G., Akin-John, Julie O., Akinlo, Oluwasemilogo O., Fayemi, Olanrewaju O., Ipaye, Testimony O., Nwodo, Deborah C., Omoniyi, Abolade E., Omwanghe, Iyobosa B., Terkuma, Christabel A., Okolie, Johnson, Ayo-Ale, Olubukola, Ikponmwosa, Odia, Benevolence, Ebo, Naregose, Grace O., Patience, Akhilomen E., Blessing, Osiemi, Micheal, Airende, Jacqueline, Agbukor, Aiyepada, John O., Ebhodaghe, Paulson, Racheal, Omiunu, Rita, Esumeh, Rosemary, Giwa E., Solomon, Ehikhametalor, Anieno, Ekanem, Edna, Yerumoh, Chris, Aire O., Donatus, Adomeh I., Ogbaini-Emovon, Ephraim, Tatfeng, Mirabeau Y., Omunakwe, Hannah E., Bob-Manuel, Mienye, Ahmed, Rahaman A., Onwuamah, Chika K., Shaibu, Joseph O., Okwuraiwe, Azuka, Ataga, Anthony E., Bock-Oruma, Andrew, Daramola, Funmi, Yusuf, Ibrahim F., Fajola, Akinwumi, Ntia, Nsikak-Abasi, Ekpo, Julie J., Moses, Anietie E., Moore-Igwe, Beatrice W., Fakayode, Oluwatosin E., Akinola, Monilade, Kida, Ibrahim M., Oderinde, Bamidele S., Wudiri, Zara W., Adeyemi, Oluwapelumi O., Akanbi, Olusola A., Ahumibe, Anthony, Akinpelu, Afolabi, Ayansola, Oyeronke, Babatunde, Olajumoke, Omoare, Adesuyi A., Chukwu, Chimaobi, Mba, Nwando G., Omoruyi, Ewean C., Olisa, Olasunkanmi, Akande, Olatunji K., Nwafor, Ifeanyi E., Ekeh, Matthew A., Ndoma, Erim, Ewah, Richard L., Duruihuoma, Rosemary O., Abu, Augustine, Odeh, Elizabeth, Onyia, Venatius, Ojide, Chiedozie K., Okoro, Sylvanus, Igwe, Daniel, Ogah, Emeka O., Khan, Kamran, Ajayi, Nnennaya A., Ugwu, Collins N., Ukwaja, Kingsley N., Ugwu, Ngozi I., Abejegah, Chukwuyem, Adedosu, Nelson, Ayodeji, Olufemi, Liasu, Ahmed A., Isamotu, Rafiu O., Gadzama, Galadima, Petros, Brittany A., Siddle, Katherine J., Schaffner, Stephen F., Akpede, George, Erameh, Cyril Oshomah, Baba, Marycelin M., Oladiji, Femi, Audu, Rosemary, Ndodo, Nnaemeka, Fowotade, Adeola, Okogbenin, Sylvanus, Okokhere, Peter O., Park, Danny J., Mcannis, Bronwyn L., Adetifa, Ifedayo M., Ihekweazu, Chikwe, Salako, Babatunde L., Tomori, Oyewale, Happi, Anise N., Folarin, Onikepe A., Andersen, Kristian G., Sabeti, Pardis C., and Happi, Christian T.
- Published
- 2023
- Full Text
- View/download PDF
3. The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response.
- Author
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Botti-Lodovico, Yolanda, Nair, Parvathy, Nosamiefan, Dolo, Stremlau, Matthew, Schaffner, Stephen, Agignoae, Sebastian, Aiyepada, John, Ajogbasile, Fehintola, Akpede, George, Alhasan, Foday, Andersen, Kristian, Asogun, Danny, Ayodeji, Oladele, Badiane, Aida, Barnes, Kayla, Bauer, Matthew, Bell-Kareem, Antoinette, Benard, Muoebonam, Benevolence, Ebo, Blessing, Osiemi, Boehm, Chloe, Boisen, Matthew, Bond, Nell, Branco, Luis, Butts, Michael, Carter, Amber, Colubri, Andres, Deme, Awa, DeRuff, Katherine, Diédhiou, Younousse, Edamhande, Akhilomen, Elhamoumi, Siham, Engel, Emily, Eromon, Philomena, Fallah, Mosoka, Folarin, Onikepe, Fry, Ben, Garry, Robert, Gaye, Amy, Gbakie, Michael, Gevao, Sahr, Gionet, Gabrielle, Gladden-Young, Adrianne, Goba, Augustine, Gomis, Jules, Happi, Anise, Houghton, Mary, Ihekwuazu, Chikwe, Iruolagbe, Christopher, Jackson, Jonathan, Jalloh, Simbirie, Johnson, Jeremy, Kanneh, Lansana, Kayode, Adeyemi, Kemball, Molly, Kingsley, Ojide, Koroma, Veronica, Kotliar, Dylan, Mehta, Samar, Metsky, Hayden, Michael, Airende, Mirhashemi, Marzieh, Modjarrad, Kayvon, Momoh, Mambu, Myhrvold, Cameron, Naregose, Okonofua, Ndiaye, Tolla, Ndiaye, Mouhamadou, Ndiaye, Aliou, Normandin, Erica, Odia, Ikponmwosa, Oguzie, Judith, Okogbenin, Sylvanus, Okokhere, Peter, Okolie, Johnson, Olawoye, Idowu, Olumade, Testimony, Oluniyi, Paul, Omoregie, Omigie, Park, Daniel, Paye, Mariétou, Petros, Brittany, Philippakis, Anthony, Priscilla, Abechi, Ricks, Alan, Rimoin, Anne, Sandi, John, Schieffelin, John, Schreiber, Monica, Seck, Mame, Siddiqui, Sameed, Siddle, Katherine, Smither, Allison, Sy, Mouhamad, Sy, Ngayo, Tomkins-Tinch, Christopher, Tomori, Oyewale, Ugwu, Chinedu, Uwanibe, Jessica, and Uyigue, Eghosasere
- Subjects
Ebola ,LARGE ,Lassa fever ,Lassa virus ,bioinformatics ,diagnostic tools ,genomic surveillance ,infectious disease ,pandemic preemption ,pandemic response ,Africa ,Western ,Disaster Planning ,Humans ,Lassa Fever ,Lassa virus ,N-Acetylglucosaminyltransferases ,Nigeria ,Pandemics ,Polymorphism ,Genetic ,Receptors ,Virus - Abstract
While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE-detected in the Yoruba population of Nigeria-conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the emerging nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunzs critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.
- Published
- 2021
4. Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages
- Author
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Heinrich, Megan L., Boisen, Matthew L., Nelson, Diana K. S., Bush, Duane J., Cross, Robert W., Koval, Anatoliy P., Hoffmann, Andrew R., Beddingfield, Brandon J., Hastie, Kathryn M., Rowland, Megan M., Aimukanova, Irina, Koval, Sophia, Lathigra, Raju, Borisevich, Viktoriya, Momoh, Mambu, Sandi, John Demby, Goba, Augustine, Odia, lkponmwosa, Baimba, Francis, Aiyepada, John O., Ebo, Benevolence, Eromon, Philomena, Ugwu, Chinedu, Folarin, Onikepe, Olumade, Testimony, Onyechi, MacDonald N., Etafo, Johnson, Adeyemi, Rashidat, Ella, Elijah E., Aminu, Maryam, Gomerep, Simji S., Eke, Matthew Afam, Ogunsanya, Olusola, Akpede, George O., Asogun, Danny O., Okogbenin, Sylvanus A., Okokhere, Peter O., Holst, Johan, Shaffer, Jeffrey G., Schieffelin, John S., Geisbert, Thomas W., Saphire, Erica Ollmann, Happi, Christian T., Grant, Donald S., Garry, Robert F., and Branco, Luis M.
- Published
- 2020
- Full Text
- View/download PDF
5. Field evaluation of a Pan-Lassa rapid diagnostic test during the 2018 Nigerian Lassa fever outbreak
- Author
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Boisen, Matthew L., Uyigue, Eghosa, Aiyepada, John, Siddle, Katherine J., Oestereich, Lisa, Nelson, Diana K. S., Bush, Duane J., Rowland, Megan M., Heinrich, Megan L., Eromon, Philomena, Kayode, Adeyemi T., Odia, Ikponmwosa, Adomeh, Donatus I., Muoebonam, Ekene B., Akhilomen, Patience, Okonofua, Grace, Osiemi, Blessing, Omoregie, Omigie, Airende, Michael, Agbukor, Jacqueline, Ehikhametalor, Solomon, Aire, Chris Okafi, Duraffour, Sophie, Pahlmann, Meike, Böhm, Wiebke, Barnes, Kayla G., Mehta, Samar, Momoh, Mambu, Sandi, John Demby, Goba, Augustine, Folarin, Onikepe A., Ogbaini-Emovan, Ephraim, Asogun, Danny A., Tobin, Ekaete A., Akpede, George O., Okogbenin, Sylvanus A., Okokhere, Peter O., Grant, Donald S., Schieffelin, John S., Sabeti, Pardis C., Günther, Stephan, Happi, Christian T., Branco, Luis M., and Garry, Robert F.
- Published
- 2020
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- View/download PDF
6. Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria
- Author
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Idowu B. Olawoye, Paul E. Oluniyi, Judith U. Oguzie, Jessica N. Uwanibe, Adeyemi T. Kayode, Testimony J. Olumade, Fehintola V. Ajogbasile, Edyth Parker, Philomena E. Eromon, Priscilla Abechi, Tope Sobajo, Chinedu Ugwu, George Uwem, Femi Ayoade, Kazeem Akano, Nicholas Oyejide, Iyanuoluwa Fred-Akintunwa, Kemi Adedotun-Sulaiman, Farida Brimmo, Benjamin Adegboyega, Courage Philip, Ayomide Adeleke, Grace C. Chukwu, Ahmed I. Muhammad, Oludayo O. Ope-ewe, Shobi Otitoola, Olusola A. Ogunsanya, Mudasiru F. Saibu, Ayotunde E. Sijuwola, Grace O. Ezekiel, Oluwagboadurami G. John, Julie O. Akin-John, Oluwasemilogo O. Akinlo, Olanrewaju O. Fayemi, Testimony O. Ipaye, Deborah C. Nwodo, Abolade E. Omoniyi, Iyobosa B. Omwanghe, Christabel A. Terkuma, Johnson Okolie, Olubukola Ayo-Ale, Odia Ikponmwosa, Ebo Benevolence, Okonofua Naregose, Akhilomen Patience, Osiemi Blessing, Airende Micheal, Agbukor Jacqueline, Aiyepada John, Paulson Ebhodaghe, Omiunu Racheal, Esumeh Rita, Giwa Rosemary, Ehikhametalor Solomon, Ekanem Anieno, Yerumoh Edna, Aire Chris, Adomeh Donatus, Ephraim Ogbaini, Mirabeau Y. Tatfeng, Hannah E. Omunakwe, Mienye Bob-Manuel, Rahaman Ahmed, Chika Onwuamah, Joseph Shaibu, Azuka Okwuraiwe, Anthony E. Atage, Andrew Bock-Oruma, Funmi Daramola, Akinwumi Fajola, Nsikak-Abasi Ntia, Julie J. Ekpo, Anietie Moses, Worbianueri B. Moore-Igwe, Ibrahim F. Yusuf, Enoch O. Fakayode, Monilade Akinola, Ibrahim Kida, Bamidele S. Oderinde, Zara Wudiri, Olufemi O. Adeyemi, Olusola Akanbi, Anthony Ahumibe, Afolabi Akinpelu, Oyeronke Ayansola, Olajumoke Babatunde, Adesuyi Omoare, Chimaobi Chukwu, Nwando Mba, Ewean C. Omoruyi, Johnson A. Adeniji, Moses O. Adewunmi, Oluseyi Olayinka, Olisa Olasunkanmi, Olatunji Akande, Ifeanyi Nwafor, Matthew Ekeh, Erim Ndoma, Richard Ewah, Rosemary Duruihuoma, Augustine Abu, Elizabeth Odeh, Venatious Onyia, Kingsley C. Ojide, Sylvanus Okoro, Daniel Igwe, Kamran Khan, Anthony N. Ajayi, Ebhodaghe Ngozi Ugwu, Collins N. Ugwu, Kingsley Ukwuaja, Emeka O. Ogah, Chukwuyem Abejegah, Nelson Adedosu, Olufemi Ayodeji, Rafiu O. Isamotu, Galadima Gadzama, Brittany Petros, Katherine J. Siddle, Stephen Schaffner, George Akpede, Cyril Oshomah Erameh, Marycelin Baba, Femi Oladiji, Rosemary Audu, Nnaemeka Ndodo, Adeola Fowotade, Sylvanus Okogbenin, Peter Okokhere, Danny Park, Bronwyn Mcannis, Ifedayo Adetifa, Chikwe Ihekweazu, Babatunde L. Salako, Oyewale Tomori, Anise N. Happi, Onikepe A. Folarin, Kristian G. Andersen, Pardis C. Sabeti, and Christian T. Happi
- Abstract
Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the B.1.1.318 and B.1.525 variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Our results show how regional connectivity in downsampled regions like Africa can often influence virus transmissions between neighbouring countries. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission in the region, generating actionable information for public health decision makers in the region.
- Published
- 2022
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7. Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
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Carroll, Miles W., Matthews, David A., Hiscox, Julian A., Elmore, Michael J., Pollakis, Georgios, Rambaut, Andrew, Hewson, Roger, García-Dorival, Isabel, Bore, Joseph Akoi, Koundouno, Raymond, Abdellati, Saïd, Afrough, Babak, Aiyepada, John, Akhilomen, Patience, Asogun, Danny, Atkinson, Barry, Badusche, Marlis, Bah, Amadou, Bate, Simon, Baumann, Jan, Becker, Dirk, Becker-Ziaja, Beate, Bocquin, Anne, Borremans, Benny, Bosworth, Andrew, Boettcher, Jan Peter, Cannas, Angela, Carletti, Fabrizio, Castilletti, Concetta, Clark, Simon, Colavita, Francesca, Diederich, Sandra, Donatus, Adomeh, Duraffour, Sophie, Ehichioya, Deborah, Ellerbrok, Heinz, Fernandez-Garcia, Maria Dolores, Fizet, Alexandra, Fleischmann, Erna, Gryseels, Sophie, Hermelink, Antje, Hinzmann, Julia, Hopf-Guevara, Ute, Ighodalo, Yemisi, Jameson, Lisa, Kelterbaum, Anne, Kis, Zoltan, Kloth, Stefan, Kohl, Claudia, Korva, Miša, Kraus, Annette, Kuisma, Eeva, Kurth, Andreas, Liedigk, Britta, Logue, Christopher H., Lüdtke, Anja, Maes, Piet, McCowen, James, Mély, Stéphane, Mertens, Marc, Meschi, Silvia, Meyer, Benjamin, Michel, Janine, Molkenthin, Peter, Muñoz-Fontela, César, Muth, Doreen, Newman, Edmund N. C., Ngabo, Didier, Oestereich, Lisa, Okosun, Jennifer, Olokor, Thomas, Omiunu, Racheal, Omomoh, Emmanuel, Pallasch, Elisa, Pályi, Bernadett, Portmann, Jasmine, Pottage, Thomas, Pratt, Catherine, Priesnitz, Simone, Quartu, Serena, Rappe, Julie, Repits, Johanna, Richter, Martin, Rudolf, Martin, Sachse, Andreas, Schmidt, Kristina Maria, Schudt, Gordian, Strecker, Thomas, Thom, Ruth, Thomas, Stephen, Tobin, Ekaete, Tolley, Howard, Trautner, Jochen, Vermoesen, Tine, Vitoriano, Inês, Wagner, Matthias, Wolff, Svenja, Yue, Constanze, Capobianchi, Maria Rosaria, Kretschmer, Birte, Hall, Yper, Kenny, John G., Rickett, Natasha Y., Dudas, Gytis, Coltart, Cordelia E. M., Kerber, Romy, Steer, Damien, Wright, Callum, Senyah, Francis, Keita, Sakoba, Drury, Patrick, Diallo, Boubacar, de Clerck, Hilde, Van Herp, Michel, Sprecher, Armand, Traore, Alexis, Diakite, Mandiou, Konde, Mandy Kader, Koivogui, Lamine, Magassouba, N’Faly, Avšič-Županc, Tatjana, Nitsche, Andreas, Strasser, Marc, Ippolito, Giuseppe, Becker, Stephan, Stoecker, Kilian, Gabriel, Martin, Raoul, Hervé, Di Caro, Antonino, Wölfel, Roman, Formenty, Pierre, and Günther, Stephan
- Published
- 2015
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8. The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response
- Author
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Harvard University--MIT Division of Health Sciences and Technology, Botti-Lodovico, Yolanda, Nair, Parvathy, Nosamiefan, Dolo, Stremlau, Matthew, Schaffner, Stephen, Agignoae, Sebastian V., Aiyepada, John Oke, Ajogbasile, Fehintola V., Akpede, George O., Alhasan, Foday, Andersen, Kristian G., Asogun, Danny A., Ayodeji, Oladele Oluwafemi, Badiane, Aida S., Barnes, Kayla, Bauer, Matthew R., Bell-Kareem, Antoinette, Benard, Muoebonam Ekene, Benevolence, Ebo Ohomoime, Blessing, Osiemi, Boehm, Chloe K., Boisen, Matthew L., Bond, Nell G., Branco, Luis M., Butts, Michael J., Carter, Amber, Colubri, Andres, Deme, Awa B., DeRuff, Katherine C., Diédhiou, Younousse, Edamhande, Akhilomen Patience, Elhamoumi, Siham, Engel, Emily J., Eromon, Philomena, Fallah, Mosoka, Folarin, Onikepe A., Fry, Ben, Garry, Robert, Gaye, Amy, Gbakie, Michael, Gevao, Sahr M., Gionet, Gabrielle, Gladden-Young, Adrianne, Goba, Augustine, Gomis, Jules Francois, Happi, Anise N., Houghton, Mary, Ihekwuazu, Chikwe, Iruolagbe, Christopher Ojemiega, Jackson, Jonathan, Jalloh, Simbirie, Johnson, Jeremy, Kanneh, Lansana, Kayode, Adeyemi, Kemball, Molly, Kingsley, Ojide Chiedozie, Koroma, Veronica, Kotliar, Dylan, Mehta, Samar, Metsky, Hayden C., Michael, Airende, Mirhashemi, Marzieh Ezzaty, Modjarrad, Kayvon, Momoh, Mambu, Myhrvold, Cameron A., Naregose, Okonofua Grace, Ndiaye, Tolla, Ndiaye, Mouhamadou, Ndiaye, Aliou, Normandin, Erica, Odia, Ikponmwosa, Oguzie, Judith Uche, Okogbenin, Sylvanus A., Okokhere, Peter O., Okolie, Johnson, Olawoye, Idowu B., Olumade, Testimony J., Oluniyi, Paul E., Omoregie, Omigie, Park, Daniel J., Paye, Mariétou Faye, Petros, Brittany A., Philippakis, Anthony A., Priscilla, Abechi, Ricks, Alan, Rimoin, Anne, Sandi, John Demby, Schieffelin, John S., Schreiber, Monica, Seck, Mame Cheikh, Siddiqui, Sameed, Siddle, Katherine, Smither, Allison R., Sy, Mouhamad, Sy, Ngayo, Tomkins-Tinch, Christopher H., Tomori, Oyewale, Ugwu, Chinedu, Uwanibe, Jessica N., Uyigue, Eghosasere Anthonia, Victoria, Dada Ireti, Vinzé, Anika, Vodzak, Megan E., Welch, Nicole, Wurie, Haja Isatta, Zoumarou, Daba, Grant, Donald S., Ndiaye, Daouda, MacInnis, Bronwyn, Sabeti, Pardis C., Happi, Christian, Harvard University--MIT Division of Health Sciences and Technology, Botti-Lodovico, Yolanda, Nair, Parvathy, Nosamiefan, Dolo, Stremlau, Matthew, Schaffner, Stephen, Agignoae, Sebastian V., Aiyepada, John Oke, Ajogbasile, Fehintola V., Akpede, George O., Alhasan, Foday, Andersen, Kristian G., Asogun, Danny A., Ayodeji, Oladele Oluwafemi, Badiane, Aida S., Barnes, Kayla, Bauer, Matthew R., Bell-Kareem, Antoinette, Benard, Muoebonam Ekene, Benevolence, Ebo Ohomoime, Blessing, Osiemi, Boehm, Chloe K., Boisen, Matthew L., Bond, Nell G., Branco, Luis M., Butts, Michael J., Carter, Amber, Colubri, Andres, Deme, Awa B., DeRuff, Katherine C., Diédhiou, Younousse, Edamhande, Akhilomen Patience, Elhamoumi, Siham, Engel, Emily J., Eromon, Philomena, Fallah, Mosoka, Folarin, Onikepe A., Fry, Ben, Garry, Robert, Gaye, Amy, Gbakie, Michael, Gevao, Sahr M., Gionet, Gabrielle, Gladden-Young, Adrianne, Goba, Augustine, Gomis, Jules Francois, Happi, Anise N., Houghton, Mary, Ihekwuazu, Chikwe, Iruolagbe, Christopher Ojemiega, Jackson, Jonathan, Jalloh, Simbirie, Johnson, Jeremy, Kanneh, Lansana, Kayode, Adeyemi, Kemball, Molly, Kingsley, Ojide Chiedozie, Koroma, Veronica, Kotliar, Dylan, Mehta, Samar, Metsky, Hayden C., Michael, Airende, Mirhashemi, Marzieh Ezzaty, Modjarrad, Kayvon, Momoh, Mambu, Myhrvold, Cameron A., Naregose, Okonofua Grace, Ndiaye, Tolla, Ndiaye, Mouhamadou, Ndiaye, Aliou, Normandin, Erica, Odia, Ikponmwosa, Oguzie, Judith Uche, Okogbenin, Sylvanus A., Okokhere, Peter O., Okolie, Johnson, Olawoye, Idowu B., Olumade, Testimony J., Oluniyi, Paul E., Omoregie, Omigie, Park, Daniel J., Paye, Mariétou Faye, Petros, Brittany A., Philippakis, Anthony A., Priscilla, Abechi, Ricks, Alan, Rimoin, Anne, Sandi, John Demby, Schieffelin, John S., Schreiber, Monica, Seck, Mame Cheikh, Siddiqui, Sameed, Siddle, Katherine, Smither, Allison R., Sy, Mouhamad, Sy, Ngayo, Tomkins-Tinch, Christopher H., Tomori, Oyewale, Ugwu, Chinedu, Uwanibe, Jessica N., Uyigue, Eghosasere Anthonia, Victoria, Dada Ireti, Vinzé, Anika, Vodzak, Megan E., Welch, Nicole, Wurie, Haja Isatta, Zoumarou, Daba, Grant, Donald S., Ndiaye, Daouda, MacInnis, Bronwyn, Sabeti, Pardis C., and Happi, Christian
- Abstract
While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE—detected in the Yoruba population of Nigeria—conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the “emerging” nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz’s critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.
- Published
- 2021
9. Phylogeography of Lassa Virus in Nigeria
- Author
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Ehichioya, Deborah U., primary, Dellicour, Simon, additional, Pahlmann, Meike, additional, Rieger, Toni, additional, Oestereich, Lisa, additional, Becker-Ziaja, Beate, additional, Cadar, Daniel, additional, Ighodalo, Yemisi, additional, Olokor, Thomas, additional, Omomoh, Emmanuel, additional, Oyakhilome, Jennifer, additional, Omiunu, Racheal, additional, Agbukor, Jacqueline, additional, Ebo, Benevolence, additional, Aiyepada, John, additional, Ebhodaghe, Paulson, additional, Osiemi, Blessing, additional, Ehikhametalor, Solomon, additional, Akhilomen, Patience, additional, Airende, Michael, additional, Esumeh, Rita, additional, Muoebonam, Ekene, additional, Giwa, Rosemary, additional, Ekanem, Anieno, additional, Igenegbale, Ganiyu, additional, Odigie, George, additional, Okonofua, Grace, additional, Enigbe, Racheal, additional, Omonegho Yerumoh, Edna, additional, Pallasch, Elisa, additional, Bockholt, Sabrina, additional, Kafetzopoulou, Liana E., additional, Duraffour, Sophie, additional, Okokhere, Peter O., additional, Akpede, George O., additional, Okogbenin, Sylvanus A., additional, Odia, Ikponmwosa, additional, Aire, Chris, additional, Akpede, Nosa, additional, Tobin, Ekaete, additional, Ogbaini-Emovon, Ephraim, additional, Lemey, Philippe, additional, Adomeh, Donatus I., additional, Asogun, Danny A., additional, and Günther, Stephan, additional
- Published
- 2019
- Full Text
- View/download PDF
10. Phylogeography of Lassa Virus in Nigeria
- Author
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Ehichioya, Deborah, Dellicour, Simon, Pahlmann, Meike, Rieger, Toni, Oestereich, Lisa, Becker-Ziaja, Beate, Cadar, Daniel, Ighodalo, Yemisi, Olokor, Thomas, Omomoh, Emmanuel, Oyakhilome, Jennifer, Omiunu, Racheal, Agbukor, Jacqueline, Ebo, Benevolence, Aiyepada, John, Ebhodaghe, Paulson, Osiemi, Blessing, Ehikhametalor, Solomon, Akhilomen, Patience, Airende, Michael, Esumeh, Rita, Muoebonam, Ekene, Giwa, Rosemary, Ekanem, Anieno, Igenegbale, Ganiyu, Odigie, George, Okonofua, Grace, Enigbe, Racheal, Omonegho Yerumoh, Edna, Pallasch, Elisa, Bockholt, Sabrina, Kafetzopoulou, Liana Eleni, Duraffour, Sophie, Okokhere, Peter, Akpede, George, Okogbenin, Sylvanus, Odia, Ikponmwosa, Aire, Chris, Akpede, Nosa, Tobin, Ekaete Alice, Ogbaini-Emovon, Ephraim, Lemey, Philippe, Adomeh, Donatus I., Asogun, Danny, Günther, Stephan, Ehichioya, Deborah, Dellicour, Simon, Pahlmann, Meike, Rieger, Toni, Oestereich, Lisa, Becker-Ziaja, Beate, Cadar, Daniel, Ighodalo, Yemisi, Olokor, Thomas, Omomoh, Emmanuel, Oyakhilome, Jennifer, Omiunu, Racheal, Agbukor, Jacqueline, Ebo, Benevolence, Aiyepada, John, Ebhodaghe, Paulson, Osiemi, Blessing, Ehikhametalor, Solomon, Akhilomen, Patience, Airende, Michael, Esumeh, Rita, Muoebonam, Ekene, Giwa, Rosemary, Ekanem, Anieno, Igenegbale, Ganiyu, Odigie, George, Okonofua, Grace, Enigbe, Racheal, Omonegho Yerumoh, Edna, Pallasch, Elisa, Bockholt, Sabrina, Kafetzopoulou, Liana Eleni, Duraffour, Sophie, Okokhere, Peter, Akpede, George, Okogbenin, Sylvanus, Odia, Ikponmwosa, Aire, Chris, Akpede, Nosa, Tobin, Ekaete Alice, Ogbaini-Emovon, Ephraim, Lemey, Philippe, Adomeh, Donatus I., Asogun, Danny, and Günther, Stephan
- Abstract
Lassa virus is genetically diverse with several lineages circulating in West Africa. This study aimed at describing the sequence variability of Lassa virus across Nigeria and inferring its spatiotemporal evolution. We sequenced and isolated 77 Lassa virus strains from 16 Nigerian states. The final data set, including previous works, comprised metadata and sequences of 219 unique strains sampled between 1969 and 2018 in 22 states. Most of this data originated from Lassa fever patients diagnosed at Irrua Specialist Teaching Hospital, Edo State, Nigeria. The majority of sequences clustered with the main Nigerian lineages II and III, while a few sequences formed a new cluster related to Lassa virus strains from Hylomyscus pamfi .Within lineages II and III, seven and five sublineages, respectively, were distinguishable. Phylogeographic analysis suggests an origin of lineage II in the southeastern part of the country around Ebonyi State and a main vector of dispersal toward the west across the Niger River, through Anambra, Kogi, Delta, and Edo into Ondo State. The frontline of virus dispersal appears to be in Ondo. Minor vectors are directed northeast toward Taraba and Adamawa and south toward Imo and Rivers. Lineage III might have spread from northern Plateau State into Kaduna, Nasarawa, Federal Capital Territory, and Bauchi. One sublineage moved south and crossed the Benue River into Benue State. This study provides a geographic mapping of lineages and phylogenetic clusters in Nigeria at a higher resolution. In addition, we estimated the direction and time frame of virus dispersal in the country. IMPORTANCE Lassa virus is the causative agent of Lassa fever, a viral hemorrhagic fever with a case fatality rate of approximately 30% in Africa. Previous studies disclosed a geographical pattern in the distribution of Lassa virus strains and a westward movement of the virus across West Africa during evolution. Our study provides a deeper understanding of the geography, SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2019
11. Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018
- Author
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Siddle, Katherine J., primary, Eromon, Philomena, additional, Barnes, Kayla G., additional, Mehta, Samar, additional, Oguzie, Judith U., additional, Odia, Ikponmwosa, additional, Schaffner, Stephen F., additional, Winnicki, Sarah M., additional, Shah, Rickey R., additional, Qu, James, additional, Wohl, Shirlee, additional, Brehio, Patrick, additional, Iruolagbe, Christopher, additional, Aiyepada, John, additional, Uyigue, Eghosa, additional, Akhilomen, Patience, additional, Okonofua, Grace, additional, Ye, Simon, additional, Kayode, Tolulope, additional, Ajogbasile, Fehintola, additional, Uwanibe, Jessica, additional, Gaye, Amy, additional, Momoh, Mambu, additional, Chak, Bridget, additional, Kotliar, Dylan, additional, Carter, Amber, additional, Gladden-Young, Adrianne, additional, Freije, Catherine A., additional, Omoregie, Omigie, additional, Osiemi, Blessing, additional, Muoebonam, Ekene B., additional, Airende, Michael, additional, Enigbe, Rachael, additional, Ebo, Benevolence, additional, Nosamiefan, Iguosadolo, additional, Oluniyi, Paul, additional, Nekoui, Mahan, additional, Ogbaini-Emovon, Ephraim, additional, Garry, Robert F., additional, Andersen, Kristian G., additional, Park, Daniel J., additional, Yozwiak, Nathan L., additional, Akpede, George, additional, Ihekweazu, Chikwe, additional, Tomori, Oyewale, additional, Okogbenin, Sylvanus, additional, Folarin, Onikepe A., additional, Okokhere, Peter O., additional, MacInnis, Bronwyn L., additional, Sabeti, Pardis C., additional, and Happi, Christian T., additional
- Published
- 2018
- Full Text
- View/download PDF
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