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285 results on '"Aittoniemi, Janne"'

1. Clinical Aspects and Disease Severity of Streptococcus dysgalactiae Subspecies equisimilis Bacteremia, Finland

Author

Nevanlinna, Viivi, Aittoniemi, Janne, Huttunen, Reetta, Luukkaala, Tiina, and Rantala, Sari

Subjects
Penicillin G -- Research, Diseases -- Research -- Care and treatment -- Japan -- Finland, C-reactive protein -- Research, Bacteremia -- Research -- Care and treatment, Health
Abstract

Streptococcus dysgalactiae subspecies equsimilis (SDSE) is a [beta]-hemolytic Streptococcus species mainly expressing Lancefield antigens C or G (1). The incidence of SDSE bacteremia has been increasing, and SDSE has surpassed [...]

Published
2024
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19. Plasma soluble urokinase-type plasminogen activator receptor (P-suPAR) in the diagnostics between malignant and non-malignant pancreatic lesions.

Author

Aronen, Anu, Aittoniemi, Janne, Huttunen, Reetta, Nikkola, Anssi, Nikkola, Jussi, Limnell, Olli, Sand, Juhani, and Laukkarinen, Johanna

Abstract

Soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker elevated in several inflammatory conditions and cancers. It has recently been shown to be elevated in pancreatic ductal adenocarcinoma (PDAC). Plasma suPAR (P-suPAR) predicts the severity of the disease in first acute alcohol-induced pancreatitis (AAP) and ten-year mortality after recovery from first AAP. According to our previous results, P-suPAR is not elevated in chronic pancreatitis (CP) and could possibly be used in distinguishing pancreatic cancer (PC) from CP. When imaging creates a suspicion of a pancreatic lesion, the distinction between malignant and non-malignant disease is crucial. Additional tools are needed, and we still lack a sufficiently sensitive and specific biomarker. Our aim was to further investigate whether preoperatively measured P-suPAR is beneficial in distinguishing between malignant and non-malignant pancreatic lesions. One hundred and seventy-six patients evaluated in Tampere University Hospital for pancreatic surgery for suspected malignant pancreatic lesion were recruited for the study. The final study group consisted of 113 patients. P-suPAR and other covariates were measured before the planned operation. P-suPAR was significantly higher in patients with pancreatic cancer (PC) [median 4.1 (IQR 3.3–5.1) ng/mL] than in patients with non-malignant [3.3 (2.9–4.4) ng/mL; p = 0.012] histology. ROC curve analysis resulted in an AUC of 0.65 (95% CI 0.55–0.76); p = 0.007 and a cutoff value of 3.2 ng/mL. Crosstabulation yielded sensitivity of 82% and specificity of 43%. A combination of positive P-suPAR and elevated plasma carbohydrate antigen 19–9 (P-CA19-9) tests did not improve sensitivity but elevated specificity up to 86–88%. Preoperative P-suPAR is elevated in patients with PC compared to patients with a non-malignant pancreatic lesion. Combining P-suPAR with P-CA19–9 may improve diagnostic accuracy. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Differential mobility spectrometry classification of bacteria

Author

Hokkinen, Lauri, primary, Kesti, Artturi, additional, Lepomäki, Jaakko, additional, Anttalainen, Osmo, additional, Kontunen, Anton, additional, Karjalainen, Markus, additional, Aittoniemi, Janne, additional, Vuento, Risto, additional, Lehtimäki, Terho, additional, Oksala, Niku, additional, and Roine, Antti, additional

Published
2020
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32. Reduced plasma PCSK9 response in patients with bacteraemia is associated with mortality

Author

Rannikko, Juha, Jacome Sanz, Dafne, Ortutay, Zsuzsanna, Seiskari, Tapio, Aittoniemi, Janne, Huttunen, Reetta, Syrjänen, Jaana, Pesu, Marko, Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, and Tampere University

Subjects
PCSK9, sepsis, bacteraemia, Sisätaudit - Internal medicine, CRP
Published
2019

36. Pregestational overweight and obesity are associated with differences in gut microbiota composition and systemic inflammation in the third trimester

Author

Zacarías, María Florencia, Collado, María Carmen, Gómez-Gallego, Carlos, Flinck, Heini, Aittoniemi, Janne, Isolauri, Erika, and Salminen, Seppo

Subjects
Physiology, Maternal Health, lcsh:Medicine, Pathology and Laboratory Medicine, Biochemistry, Body Mass Index, Pregnancy, RNA, Ribosomal, 16S, Medicine and Health Sciences, Prospective Studies, lcsh:Science, Immune Response, Obstetrics and Gynecology, Genomics, C-Reactive Protein, Physiological Parameters, Medical Microbiology, Female, Research Article, Adult, DNA, Bacterial, Pregnancy Trimester, Third, Immunology, Microbial Genomics, Microbiology, Receptors, Urokinase Plasminogen Activator, Signs and Symptoms, Diagnostic Medicine, Genetics, Humans, Obesity, Inflammation, Plasma Proteins, Haptoglobins, Bacteria, Body Weight, Gut Bacteria, lcsh:R, Organisms, Biology and Life Sciences, Proteins, Sequence Analysis, DNA, Overweight, Gastrointestinal Microbiome, Pregnancy Complications, Women's Health, lcsh:Q, Microbiome, Biomarkers, Follow-Up Studies
Abstract

The obesity epidemic is a global challenge, and the velocity of propagation is high in the population at reproductive age. Overweight and obesity during pregnancy have been associated with high birth weight and an increased risk of childhood obesity, reinforcing the risk of other non-communicable diseases. Obesity involves chronic low-grade systemic inflammation. New biomarkers for early detection of obesity risk are urgently required. The aim of this study was to identify the connection between pregestational BMI (pre-BMI) status and inflammatory biomarkers during the third trimester of pregnancy and their association with intestinal microbiota composition. Fifty-four pregnant women were classified according to pre-pregnancy BMI as normoweight, overweight, or obese. Weight gain, inflammatory biomarkers (hs_CRP, haptoglobin, and suPAR), and microbiota composition were assessed during the third trimester. A significant lower weight gain for obese mothers and a positive correlation between pre-BMI and inflammatory biomarkers were detected (Spearman’s correlation). Haptoglobin levels were significantly higher in overweight and obese mothers. Higher Firmicutes levels and a higher ratio Firmicutes/Bacteroidetes were observed in the overweight and obese subjects. High hs_CRP and haptoglobin levels were also correlated with decreased microbiota diversity (Shannon index), whereas haptoglobin and hs_CRP values were correlated with several microbiota components, such as Ruminococcus gnavus and Faecalibacterium, and with specific phyla in the normoweight and overweight mothers; no significant associations with microbiota were found for suPAR. In conclusion, haptoglobin and hs_CRP reflected pregestational BMI status and related microbiota components, but haptoglobin was a better biomarker for microbiota associated with overweight. suPAR was associated with low grade inflammation dependent on pre-pregnancy BMI, but it was not related to deviated microbiota profiles., This work was funded by TEKES (Grant N° 3825/31/2015, Finland). TEKES is not a commercial source but a government funding agency and this funding does not alter our adherence to PLOS ONE policies. As for the authors (Flinck, H and Aittoniemi, J) employed by the company Fimlab Laboratories Ltd, the firm is the laboratory service of the Tampere University Hospital and only provided support in the form of salaries for authors but did not have any additional role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.

Published
2018

39. Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019

Author

Rantakokko-Jalava, Kaisu, primary, Hokynar, Kati, additional, Hieta, Niina, additional, Keskitalo, Anniina, additional, Jokela, Pia, additional, Muotiala, Anna, additional, Jokiranta, T. Sakari, additional, Kuusela, Rutta, additional, Sarkkinen, Hannu, additional, Aittoniemi, Janne, additional, Vuorinen, Tytti, additional, Hakanen, Antti J, additional, and Puolakkainen, Mirja, additional

Published
2019
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41. Plasma suPAR may help to distinguish between chronic pancreatitis and pancreatic cancer.

Author

Aronen, Anu, Aittoniemi, Janne, Huttunen, Reetta, Nikkola, Anssi, Rinta-Kiikka, Irina, Nikkola, Jussi, Limnell, Olli, Nordback, Isto, Sand, Juhani, and Laukkarinen, Johanna

Subjects
*PANCREATIC cancer, *PLASMINOGEN activators, *RECEIVER operating characteristic curves, *HUMAN body, *DIAGNOSIS, *CHRONIC pancreatitis
Abstract

SuPAR (soluble urokinase-type plasminogen activator receptor) is a biomarker reflecting the inflammatory state of the human body. Earlier studies suggest that urinary suPAR/creatinine ratio levels are elevated in chronic pancreatitis (CP), and that plasma suPAR (P-suPAR) level is elevated in pancreatic cancer (PC). Our aim was to study the levels of P-suPAR in CP in a long-term prospective follow-up setting to explore the possibility of distinguishing between PC and CP. Two patient groups were compared. The first group included 83 patients who were prospectively followed up after their first acute alcohol-induced pancreatitis (AAP) for median 7.0 (range 0.3–9.8) years. Twelve patients in this group developed CP during follow-up, and two patients were further excluded from the CP cohort. The second group consisted of 25 patients operated on for suspicion of pancreatic malignancy and final pathological diagnosis of PC. P-suPAR levels were measured and compared within and between these groups. P-suPAR levels remained low during follow-up despite the development of CP. P-suPAR was significantly higher in PC patients [median 3.7 (IQR 3.1–4.4) ng/mL] than in CP patients [2.6 (1.8–3.6) ng/mL]; p =.014. A cutoff value of 2.8 ng/mL resulted from a ROC curve with area under curve (AUC) of 0.79 (95% CI 0.61–0.97), p =.009 in differentiation between PC and CP with a sensitivity and a specificity of 88% and 70% respectively. P-suPAR is higher in patients with PC than in patients with CP, and it could thus be used in differentiating between PC and CP. [ABSTRACT FROM AUTHOR]

Published
2021
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45. Electronic Nose in the Detection of Wound Infection Bacteria from Bacterial Cultures: A Proof-of-Principle Study

Author

Saviauk, Taavi, primary, Kiiski, Juha P., additional, Nieminen, Maarit K., additional, Tamminen, Nelly N., additional, Roine, Antti N., additional, Kumpulainen, Pekka S., additional, Hokkinen, Lauri J., additional, Karjalainen, Markus T., additional, Vuento, Risto E., additional, Aittoniemi, Janne J., additional, Lehtimäki, Terho J., additional, and Oksala, Niku K., additional

Published
2018
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49. Alahengitystieinfektiot (lapset)

Author

Korppi, Matti, Aittoniemi, Janne-Juhana, Immonen, Johanna, Jylkkä, Heli, Meinander, Tuula, Nuolivirta, Kirsi, Peltola, Ville, Salo, Eeva, Seuri, Raija, Tapianen, Terhi, Walle, Satu-Maaria, Lääketieteen yksikkö - School of Medicine, and University of Tampere

Subjects
Naisten- ja lastentaudit - Gynaecology and paediatrics
Abstract

Käypä hoito -suositus, tiivistelmä

Published
2014

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