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25 results on '"Aithal, Abhijit"'

1. Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies

Author

Shah, Ashu, Chaudhary, Sanjib, Lakshmanan, Imayavaramban, Aithal, Abhijit, Kisling, Sophia G., Sorrell, Claire, Marimuthu, Saravanakumar, Gautam, Shailendra K., Rauth, Sanchita, Kshirsagar, Prakash, Cox, Jesse L., Natarajan, Gopalakrishnan, Bhatia, Rakesh, Mallya, Kavita, Rachagani, Satyanarayana, Nasser, Mohd Wasim, Ganti, Apar Kishor, Salgia, Ravi, Kumar, Sushil, Jain, Maneesh, Ponnusamy, Moorthy P., and Batra, Surinder K.

Published
2023
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8. Mucins as Potential Biomarkers for Early Detection of Cancer

Author

Gautam, Shailendra K., primary, Khan, Parvez, additional, Natarajan, Gopalakrishnan, additional, Atri, Pranita, additional, Aithal, Abhijit, additional, Ganti, Apar K., additional, Batra, Surinder K., additional, Nasser, Mohd W., additional, and Jain, Maneesh, additional

Published
2023
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10. Endothelin-axis antagonism enhances tumor perfusion in pancreatic cancer

Author

Gautam, Shailendra K., primary, Dalal, Vipin, additional, Sajja, Balasrinivasa R., additional, Gupta, Suprit, additional, Gulati, Mansi, additional, Dwivedi, Nidhi V., additional, Aithal, Abhijit, additional, Cox, Jesse L., additional, Rachagani, Satyanarayana, additional, Liu, Yutong, additional, Chung, Vincent, additional, Salgia, Ravi, additional, Batra, Surinder K., additional, and Jain, Maneesh, additional

Published
2022
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11. Polyanhydride based nanovaccine promotes long term humoral and cellular response to PDAC associated protein MUC4β

Author

Christiansen, John C, primary, Liu, Luman, additional, Kshirsagar, Prakash, additional, Wafa, Emad, additional, Gautam, Shailendra, additional, Aithal, Abhijit, additional, Gulati, Mansi, additional, Kumar, Sushil, additional, Solheim, Joyce, additional, Batra, Surinder, additional, Salem, Aliasger, additional, Jain, Maneesh, additional, Wannemuehler, Michael, additional, and Narasimhan, Balaji, additional

Published
2022
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12. Characterization of Recombinant β Subunit of Human MUC4 Mucin (rMUC4β)

Author

Kshirsagar, Prakash G., primary, Gulati, Mansi, additional, Junker, Wade M., additional, Aithal, Abhijit, additional, Spagnol, Gaelle, additional, Das, Srustidhar, additional, Mallya, Kavita, additional, Gautam, Shailendra K., additional, Kumar, Sushil, additional, Sorgen, Paul, additional, Pandey, Krishan K., additional, Batra, Surinder K., additional, and Jain, Maneesh, additional

Published
2021
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14. Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β

Author

Liu, Luman, primary, Kshirsagar, Prakash, additional, Christiansen, John, additional, Gautam, Shailendra K., additional, Aithal, Abhijit, additional, Gulati, Mansi, additional, Kumar, Sushil, additional, Solheim, Joyce C., additional, Batra, Surinder K., additional, Jain, Maneesh, additional, Wannemuehler, Michael J., additional, and Narasimhan, Balaji, additional

Published
2020
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16. Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β.

Author

Liu, Luman, Kshirsagar, Prakash, Christiansen, John, Gautam, Shailendra K., Aithal, Abhijit, Gulati, Mansi, Kumar, Sushil, Solheim, Joyce C., Batra, Surinder K., Jain, Maneesh, Wannemuehler, Michael J., and Narasimhan, Balaji

Abstract

Pancreatic cancer (PC) is one of the most lethal malignancies and represents an increasing and challenging threat, especially with an aging population. The identification of immunogenic PC‐specific upregulated antigens and an enhanced understanding of the immunosuppressive tumor microenvironment have provided opportunities to enable the immune system to recognize cancer cells. Due to its differential upregulation and functional role in PC, the transmembrane mucin MUC4 is an attractive target for immunotherapy. In the current study we characterized the antigen stability, antigenicity and release kinetics of a MUC4β‐nanovaccine to guide further optimization and, in vivo evaluation. Amphiphilic polyanhydride copolymers based on 20 mol % 1,8‐bis(p‐carboxyphenoxy)‐3,6‐dioxaoctane and 80 mol % 1,6‐bis(p‐carboxyphenoxy)hexane were used to synthesize nanoparticles. Structurally stable MUC4β protein was released from the particles in a sustained manner and characterized by gel electrophoresis and fluorescence spectroscopy. Modest levels of protein degradation were observed upon release. The released protein was also analyzed by MUC4β‐specific monoclonal antibodies using ELISA and showed no significant loss of epitope availability. Further, mice immunized with multiple formulations of combination vaccines containing MUC4β‐loaded nanoparticles generated MUC4β‐specific antibody responses. These results indicate that polyanhydride nanoparticles are viable MUC4β vaccine carriers, laying the foundation for evaluation of this platform for PC immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2021
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18. MUC16 as a novel target for cancer therapy

Author

Aithal, Abhijit, primary, Rauth, Sanchita, additional, Kshirsagar, Prakash, additional, Shah, Ashu, additional, Lakshmanan, Imayavaramban, additional, Junker, Wade M., additional, Jain, Maneesh, additional, Ponnusamy, Moorthy P., additional, and Batra, Surinder K., additional

Published
2018
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20. Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

Author

Aithal, Abhijit, primary, Junker, Wade M., additional, Kshirsagar, Prakash, additional, Das, Srustidhar, additional, Kaur, Sukhwinder, additional, Orzechowski, Catherine, additional, Gautam, Shailendra Kumar, additional, Jahan, Rahat, additional, Sheinin, Yuri M., additional, Lakshmanan, Imayavaramban, additional, Ponnusamy, Moorthy P., additional, Batra, Surinder K., additional, and Jain, Maneesh, additional

Published
2018
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21. Abstract 3678: Muc4 nanovaccine and checkpoint blockade based combination immunotherapy for pancreatic cancer

Author

Banerjee, Kasturi, primary, Gautam, Shailendra, additional, Nasser, Waseem Mohd., additional, Kshirsagar, Prakash, additional, Ross, Kathleen, additional, Spagnol, Gaelle, additional, Aithal, Abhijit, additional, Sorgen, Paul, additional, Batra, Surinder Kumar, additional, Kumar, Sushil, additional, Narasimhan, Balaji, additional, and Jain, Maneesh, additional

Published
2017
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22. A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study

Author

Kaur, Sukhwinder, primary, Smith, Lynette M, additional, Patel, Asish, additional, Menning, Melanie, additional, Watley, Duncan C, additional, Malik, Saad S, additional, Krishn, Shiv Ram, additional, Mallya, Kavita, additional, Aithal, Abhijit, additional, Sasson, Aaron R, additional, Johansson, Sonny L, additional, Jain, Maneesh, additional, Singh, Shailender, additional, Guha, Sushovan, additional, Are, Chandrakanth, additional, Raimondo, Massimo, additional, Hollingsworth, Michael A, additional, Brand, Randall E, additional, and Batra, Surinder K, additional

Published
2017
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24. DNA Promoter Methylation-dependent Transcription of the Double C2-like Domain β (DOC2B) Gene Regulates Tumor Growth in Human Cervical Cancer

Author

Kabekkodu, Shama Prasada, primary, Bhat, Samatha, additional, Radhakrishnan, Raghu, additional, Aithal, Abhijit, additional, Mascarenhas, Roshan, additional, Pandey, Deeksha, additional, Rai, Lavanya, additional, Kushtagi, Pralhad, additional, Mundyat, Gopinath Puthiya, additional, and Satyamoorthy, Kapaettu, additional

Published
2014
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