Search

Drug-induced erythema in the distribution of prior sunburn is called photo recall.  Although more commonly induced by chemotherapeutics, it has also been associated with antibiotics such as ampicillin, cephalosporin, and gentamicin. Vancomycin has not been previously reported as a causal agent.  This case report describes photo recall in a fifty-three year old woman undergoing treatment with vancomycin for a MRSA infection of the spine. Her eruption followed a photo-distributed pattern on the chest, shoulders, neck and face sparing areas previously protected by her bathing suit. Of note, she reported a similar eruption following vancomycin two years prior.

Abstract Background The phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients suggests the involvement of other genes, besides CFTR. Here, we combined transcriptome and proteome analysis to understand the global gene expression patterns associated with five prototypical CFTR mutations. Results Evaluation of differentially expressed genes and proteins unveiled common and mutation-specific changes revealing functional signatures that are much more associated with the specific molecular defects associated with each mutation than to the CFTR loss-of-function phenotype. The combination of both datasets revealed that mutation-specific detected translated-transcripts (Dtt) have a high level of consistency. Conclusions This is the first combined transcriptomic and proteomic study focusing on prototypical CFTR mutations. Analysis of Dtt provides novel insight into the pathophysiology of CF, and the mechanisms through which each mutation class causes disease and will likely contribute to the identification of new therapeutic targets and/or biomarkers for CF.

The ability of anaerobic digestion to create value from waste gives it an important role in reducing greenhouse gas emissions and in the transition to a circular economy. For a better understanding of the digestion process and in order to reduce the number of time-consuming batch tests, an analytical model was developed to describe the kinetics of biogas production. Assuming that the organic fraction of the substrate has different degradation rates, the whole process was modelled as two groups of 1st order reactions.The model was tested with published data and showed an excellent performance in reproducing the experimental information. Moreover, its kinetic constants provided a useful insight into the internal processes of anaerobic digestion and the substrate characteristics. Given its accuracy in fitting the data, the model can be used as an auxiliary tool to determine the biogas potential, presenting itself as the most complete empirical model currently available.

Abstract Objectives To analyze the results of anterior cruciate ligament (ACL) reconstruction with remnant-preserving versus remnant-resecting technique, concerning the return to pre-lesion activity level. Methods The present retrospective cohort study has assessed adults > 18 years old who underwent ACL anatomical reconstruction between 2010 and 2014. The main outcomes assessed were: level of physical activity (4-point scale), sports participation rate, ACL rerupture defined as documented lesion requiring revision surgery and the numeric pain scale rate (NPSR). Results A total of 83 individuals were included in the study, with a mean age of 31.8 years old and follow-up mean time of 4.2 years after the surgery. A total of 34 patients underwent ACL reconstruction with remnant-preserving technique, and 49 without remnant preservation. No statistically significant difference was found between groups in all outcomes assessed: level of physical activity before the lesion and after the surgery, ACL rerupture rates and postoperative pain level. Subgroup analysis has shown a statistically significant decrease in the activity level in both groups. The most practiced sport was football; 72% of patients in the remnant group have resumed football activity versus 52.6% of the control group. Conclusion Based in these findings, the comparison between ACL reconstruction with remnant preserving technique and remnant resecting technique has shown no differences concerning the return to prelesion activity level.

The main objective of this study is to describe a surgical technique that combines intra- and extra-articular techniques using the semitendinosus, gracilis, and peroneus longus to perform reconstruction of the anterior cruciate ligament and anterolateral ligament. This technique offers a more stable, fast, low-cost, and widely accessible procedure and consists of drilling 3 tunnels—1 femoral and 2 tibial tunnels—in which the grafts are fixed with interference screws. The fact that the peroneus longus graft is long and thick allows for robust reconstruction of the aforementioned ligaments.

Most cases of Cystic Fibrosis (CF) are diagnosed early in life. However, people with atypical CF forms pose diagnosis dilemmas, requiring laboratory support for diagnosis confirmation/exclusion. Ex vivo analysis of fresh rectal biopsies by Ussing chamber has been the best discriminant biomarker for CF diagnosis/prognosis so far. Here we aimed to evaluate different electrophysiological parameters from Ussing chamber analysis of rectal biopsies from people with CF (PwCF) to establish the one with highest correlations with clinical features as the best CF diagnosis/prognosis biomarker. We analyzed measurements of CFTR-mediated Cl– secretion in rectal biopsies from 143 individuals (∼592 biopsies), the largest cohort so far analyzed by this approach. New parameters were analyzed and compared with the previous biomarker, i.e., the IBMX (I)/Forskolin (F)/Carbachol (C)-stimulated short-circuit current (I’sc–I/F/C). Correlations with clinical features showed that the best parameter corresponded to voltage measurements of the I/F + (I/F/CCH) response (VI/F+I/F/C), with higher correlations vs. I’sc–I/F/C for: sweat chloride (59 vs. 52%), fecal elastase (69 vs. 55%) and lung function, measured by FEV1 (27 vs. 20%). Altogether data show that VI/F+I/F/C is the most sensitive, reproducible, and robust predictive biomarker for CF diagnosis/prognosis effectively discriminating classical, atypical CF and non-CF groups.

The aim of this study was to review and update the literature in regard to the anatomy of the femoral origin of the ACL, the concept of the double band and its respective mechanical functions, and the concept of direct and indirect fibres in the ACL insertion. These topics will be used to help determine which might be the best place to position the femoral tunnel and how this should be achieved, based on the idea of functional positioning, that is, where the most important ACL fibres in terms of knee stability are positioned. Low positioning of the femoral tunnel, reproducing more of the posterolateral band, and positioning the tunnel away from the lateral intercondylar ridge, that is, in the indirect fibres, would theoretically rebuild a ligament that is less effective in relation to knee stability. The techniques described to determine the femoral tunnel’s centre point all involve some degree of subjectivity; the point is defined manually and depends on the surgeon’s expertise. The centre of the ACL insertion in the femur should be used as a parameter. Once the centre of the ligament in its footprint is marked, the centre of the tunnel must be defined, drawing the marking toward the intercondylar ridge and anteromedial band. This will allow the femoral tunnel to occupy the region containing the most important original ACL fibres in terms of this ligament’s function.

Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels in cancer cells, where it inhibits apoptosis, and supports cell migration and proliferation. The Ca2+-activated chloride channel TMEM16A shows similar effects in cancer cells: TMEM16A increases cell proliferation and migration and is highly expressed in squamous cell carcinoma of the head and neck (HNSCC) as well as other malignant tumors. A microscopy-based high-throughput screening was performed to identify proteins that regulate TMEM16A. Within this screen, CK2 was found to be required for proper membrane expression of TMEM16A. small interfering (si) RNA-knockdown of CK2 reduced plasma membrane expression of TMEM16A and inhibited TMEM16A whole cell currents in (cystic fibrosis bronchial epithelial) CFBE airway epithelial cells and in the head and neck cancer cell lines Cal33 and BHY. Inhibitors of CK2, such as TBB and the preclinical compound CX4549 (silmitasertib), also blocked membrane expression of TMEM16A and Ca2+-activated whole cell currents. siRNA-knockout of CK2 and its pharmacological inhibition, as well as knockdown or inhibition of TMEM16A by either niclosamide or Ani9, attenuated cell proliferation. Simultaneous inhibition of CK2 and TMEM16A strongly potentiated inhibition of cell proliferation. Although membrane expression of TMEM16A is reduced by inhibition of CK2, our data suggest that the antiproliferative effects by inhibition of CK2 are mostly independent of TMEM16A. Simultaneous inhibition of TMEM16A by niclosamide and inhibition of CK2 by silmitasertib was additive with respect to blocking cell proliferation, while cytotoxicity was reduced when compared to solely blockade of CK2. Therefore, parallel blockade TMEM16A by niclosamide may assist with anticancer therapy by silmitasertib.

OBJECTIVE: The aim of this study was to analyze the blood serum levels of CTX-II in professional indoor soccer players, at three different times during one season: at the start of the pre-season, four months later (a time that marks the middle of the season) and at the end of the season.METHODS: Fourteen male soccer players of mean age 19 years were included. Blood samples of 3 mL were collected from each individual. The samples were analyzed by means of Elisa tests.RESULTS: There was a significant increase in the serum level of CTX-II in the indoor soccer players, from the beginning to the end of the season (p< 0.01).CONCLUSION: These data suggest that joint degradation had occurred in these soccer players, by the end of this period. It is evident that further studies are needed, with methodological rigor, so as to make an effective contribution toward precise elucidation of the etiology of this osteoarthritis and its relationship with the biomarkers, as a tool for early diagnosis.

Objective: To assess the presence of tibial bone tunnel enlargement after surgical reconstruction of the anterior cruciate ligament using quadruple graft of the flexor tendons and correlate the functional results in their presence. Methods: The studied lasted six months and included 25 patients, with ages ranging from 18 to 43 years old. Assessment was based on radiographs taken immediately postoperatively and at the third and sixth month of follow up in the anterior cruciate ligament reconstruction. Reconstruction of ligaments was performed with tendon grafts of the semitendinosus and gracilis muscle fixated in the femur with transverse metal screw and in the tibia with interference screws. Patients were evaluated objectively by tests ligament, graded from zero to four crosses and subjectively by the Lysholm method preoperative and after sixth month follow up. Results: Significant increase in the tunnels diameters were observed, 20.56% for radiographs in the anteroposterior view, 26.48% in profile view and 23.22% in computed tomography. Descriptive statistics showed significant improvement in subjective and objective clinical parameters. Conclusions: The bone tunnel enlargement is a phenomenon found in the first months after surgical reconstruction of the anterior cruciate ligament and it has no implications on clinical outcomes in the short term. Level of Evidence II, Prospective Study.

The aim of this study was to alert doctors to the existence of Turco's injury and discus the existing treatments that have been described in the worldwide literature. A bibliographic survey of Lisfranc's injury and Turco's injury covering from 1985 to 2013 was conducted in the SciELO and PubMed databases. Among the 193 articles, those relating to bone-ligament injuries of the Lisfranc joint and high-energy trauma were excluded, as were the case reports. The patients selected were professional or amateur athletes who solely presented a ligament injury to the Lisfranc joint (Turco's injury), which was diagnosed from the history, physical examination, radiographs and magnetic resonance images. Non-athletic patients and those with associated bone injuries were excluded (10). According to the injury classification, the patients were treated by means of either an open or a closed procedure and then a standard rehabilitation protocol. Out of the 10 patients, five underwent conservative treatment and five underwent surgical treatment using different techniques and synthesis materials. We obtained two poor results, one satisfactory, five good and two excellent. We conclude that the correct diagnosis has a direct influence on the treatment and on the final result obtained, and that lack of knowledge of this injury is the main factor responsible for underdiagnosing Turco's injury. There is a need for randomized prospective studies comparing the types of synthesis and evolution of treated cases, in order to define the best treatment for this injury.

Objective: To demonstrate the safety of soccer for adolescents in terms of chronic lesions of the lumbar spine, particularly spondylolysis. Methods: 54 young players underwent a pre-season assessment. The athletes were submitted to radiography of the lumbosacral spine. Players complaining of chronic low back pain were later submitted to more specific tests. Results: only 1 athlete (1.85 % of our sample) had complaints of chronic low back pain. In this case, the radiograph showed olisthesis grade I spondylolysis at the L5 level. Conclusion: Soccer proved to be a very safe sport in terms of the risk of developing chronic lesions of the lumbosacral spine. However, the actual incidence of spondylolysis in these athletes was not determined because only plain radiographs were used in this study.

A luxação do tendão do bíceps femoral é uma condição rara, descrita na literatura clinicamente com uma dor lateral do joelho e inicialmente relatada como uma inserção anômala da cabeça longa do bíceps femoral. Depois se verificou que a causa é uma mobilidade anormal do tendão sobre a proeminência da cabeça da fíbula em determinados ângulos de flexão do joelho. O objetivo deste relato de caso raro é descrever e discutir sobre o quadro de dor lateral no joelho num atleta de natação que iniciou a subluxação do bíceps femoral durante a prática esportiva, que o incapacitava de realizar provas e torneios. O caso é discutido frente à literatura levantada, à provável etiologia traumática de repetição que levou a essa condição, além do tratamento cirúrgico que foi realizado, obtendo excelente resultado e retorno a prática esportiva habitual.Dislocation of the femoral biceps tendon is rare and is described clinically in the literature as a lateral pain in the knee. It was initially reported as an anomalous insertion of the long head of the femoral biceps. Subsequently, it was found to be caused by abnormal mobility of the tendon over the prominence of the fibu lar head at certain angles of knee flexion. The objective of the present report was to describe and discuss a condition of lateral knee pain in a swimmer who started to present subluxation of the femoral biceps during sports practice, which incapacitated him from taking part in trials and competitions. The case is dis cussed in the light of the literature surveyed; the likelihood that the etiology for the trauma leading to this condition was repeti tion; and the surgical treatment instituted, which led to excellent results and the patient's return to his habitual sports practice.

OBJETIVO: O objetivo deste estudo foi realizar uma análise comparativa dos resultados da avaliação isocinética de força entre jogadores de futebol masculino profissional de campo e de salão e correlacioná-los aos índices de maior risco de lesão descritos na literatura. MÉTODOS: Analisamos 16 atletas jogadores de futebol de campo e 15 atletas jogadores de futsal. Todos os profissionais eram do sexo masculino e tiveram seus joelhos submetidos à avaliação isocinética da força muscular. RESULTADOS: A média de peso foi de 81,81kg para futebol de campo e 80,33kg para o futsal. Os picos de torque extensor direito e esquerdo para o futebol de campo e salão foram, respectivamente, 302,50 e 313,31Nm e 265,20 e 279,80Nm e, para flexores, 178 e 184,88Nm e 158,27 e 154Nm. Os índices de pico de torque por peso corpóreo dos extensores direito e esquerdo para o futebol de campo e salão foram, respectivamente, 3,84 e 3,7Nm/kg e 3,32 e 3,52Nm/ kg e, para flexores, 2,17 e 2,26Nm/kg e 1,98 e 1,93Nm/kg. A relação de equilíbrio entre músculos flexores e extensores dos lados direito e esquerdo para o futebol de campo e futsal foram, respectivamente, 59,81 e 59,44% e 60,47 e 54,80%. Os índices da relação de extensores entre os lados direito e esquerdo do futebol de campo e salão foram, respectivamente, 11,44 e 9,20% e, para os flexores, 7,31 e 8,80%. CONCLUSÕES: De acordo com parâmetros internacionais, a análise comparativa dos resultados da avaliação isocinética de força entre jogadores de futebol masculino profissional de campo e de salão na pré-temporada mostra que existe equilíbrio muscular e baixa probabilidade de lesão. Não existem diferenças estatisticamente significativas entre os parâmetros analisados dos jogadores das duas modalidades.OBJECTIVE: The objective of this study was to conduct a comparative analysis on isokinetic strength assessments between field and indoor male professional soccer players and correlate the findings with the higher levels of injury risk described in the literature. METHODS: We analyzed 16 field soccer players and 15 indoor soccer players. All these professionals were male. Isokinetic muscle strength assessments were made on their knees. RESULTS: The mean weight was 81.81 kg for field soccer and 80.33 kg for indoor soccer. The right and left peak extensor torque left and rightfor field soccer and indoor soccer were, respectively, 302.50 and 313.31 Nm and 265.20 and 279.80 Nm, and for flexors, 178 and 184.88 Nm and 158.27 and 154 Nm. The peak torque rates according to body weight for the left and right extensors for field soccer and indoor soccer were, respectively, 3.84 and 3.7 Nm/kg and 3.32 and 3.52 Nm/kg, and for flexors, 2.17 and 2.26 Nm/kg and 1.98 and 1.93 Nm/kg. The balance relationships between flexors and extensors on the right and left sides for field soccer and indoor soccer were, respectively, 59.81 and 59.44% and 60.47% and 54.80%. The relationships for extensors between the right and left sides for field soccer and indoor soccer were, respectively, 11.44 and 9.20%, and for the flexors, 7.31 and 8.80%. CONCLUSIONS: In accordance with international parameters, comparative analysis on isokinetic strength assessments between field and indoor male professional soccer players before the season showed that there was muscle balance and low probability of injury. There were no statistically significant differences in the parameters analyzed between the players of the two types of soccer.

OBJETIVO: Avaliar as lesões musculoesqueléticas em atletas de elite da luta olímpica. MÉTODOS: Avaliação retrospectiva de 95 atletas por meio de um questionário estruturado contendo informações sobre lesões prévias e dados clínicos e epidemiológicos. RESULTADOS: Foram relatadas 145 lesões em 81 (85,3%) atletas. As regiões anatômicas mais freqüentemente acometidas foram o joelho (25,5%), o ombro (20%), a coxa (15,2%) e o tornozelo (14,5%). As entorses e as lesões musculares foram as lesões mais comumente relatadas com 34,5% e 30,4%, respectivamente. O tratamento cirúrgico foi necessário em 9% das lesões e a maioria destas lesões (61,5%) localizavam-se nos membros.inferiores. CONCLUSÕES: Lesões do aparelho locomotor são frequentes nos praticantes de luta olímpica e os membros inferiores são o segmento mais acometido.OBJECTIVE: The present study aimed to retrospectively evaluate musculoskeletal injuries in elite Brazilian wrestlers. METHODS: Ninety-five wrestlers completed a structured questionnaire to asses wrestling injury history and clinical and demographic data. RESULTS: Eighty one athletes (85,3%) informed 145 lesions. The most commonly injured body regions were knee (25,5%), shoulder (20%), thigh (15,2%) and ankle (14,5%). Sprains (34,5%) and muscle lesions (30,4%) were the most common injuries. Surgical treatment was performed in 9% of the lesions and the majority of these lesions (61,5%) were located in the lower limbs. CONCLUSIONS: Musculoskeletal lesions are common in wrestling athletes and the lower limbs are the most frequently injured site.

OBJETIVO: Constatar a presença do alargamento do túnel ósseo tibial após a cirurgia de reconstrução do ligamento cruzado anterior usando enxerto quádruplo de tendões flexores e propor uma nova técnica para sua mensuração. MÉTODOS: O estudo durou seis meses, com 25 pacientes de idades variando entre 18 e 43 anos. A avaliação baseou-se em radiografias realizadas no pós-operatório imediato, terceiro e sexto meses de evolução das operações de reconstrução dos ligamentos cruzados anteriores reconstruídos com os enxertos do tendão do músculo semitendíneo e do músculo grácil, fixados no fêmur com parafuso transverso metálico e, na tíbia, com parafuso de interferência. As radiografias foram avaliadas pelo valor relativo entre o diâmetro do túnel e do osso, ambos 2cm abaixo do côndilo tibial medial. RESULTADOS: Aumento significativo dos diâmetros dos túneis, de 20,56% para radiografias na incidência anteroposterior e de 26,48% na incidência de perfil. O alargamento esteve presente em 48% das radiografias AP e perfil, porém esteve presente nas duas incidências em apenas 16% dos casos. CONCLUSÕES: O alargamento dos túneis ósseos é um fenômeno presente nos primeiros meses após a cirurgia de reconstrução do ligamento cruzado anterior. A técnica de mensuração proposta neste estudo é suficiente para sua detecção.OBJECTIVE: To assess the presence of tibial bone tunnel enlargement after surgery to reconstruct the anterior cruciate ligament using quadruple flexor tendon grafts, and to propose a new technique for its measurement. METHODS: The study involved 25 patients aged 18-43 years over a six-month period. The assessment was based on radiographs taken immediately postoperatively and in the third and sixth months of evolution after operations to reconstruct the anterior cruciate ligament using grafts from the tendons of the semitendinosus and gracilis muscles, fixed in the femur with a transverse metal screw and in the tibia with an interference screw. The radiographs were evaluated in terms of the relative value between the diameter of the tunnel and the bone, both at 2 cm below the medial tibial condyle. RESULTS: There were significant increases in tunnel diameters: 20.56% for radiographs in anteroposterior view and 26.48% in lateral view. Enlargement was present in 48% of anteroposterior and lateral radiographs, but was present in both views in only 16% of the cases. CONCLUSIONS: Bone tunnel enlargement is a phenomenon found in the first months after surgery to reconstruct the anterior cruciate ligament. The measurement technique proposed in this study was sufficient to detect it.

O aumento da utilização dos tendões dos músculos grácil e semitendíneo nos procedimentos de reconstrução ligamentar do joelho foi acompanhado de um aumento nas complicações provenientes da extração dos mesmos, como: lesão do ligamento colateral tibial, lesão do nervo safeno, retirada equivocada do tendão do músculo sartório, secção dos próprios tendões e aumento do tempo cirúrgico por imperícia ou desconhecimento da anatomia da região medial do joelho(1-6). Como a extração destes tendões tem sido um fator limitante em alguns procedimentos ortopédicos, realizamos este estudo dissecando 30 joelhos de cadáveres com os seguintes objetivos: localizar a inserção dos músculos grácil e semitendíneo na tíbia; verificar se existe correlação entre esta localização com a estatura do cadáver e avaliar as possíveis variações anatômicas. Observamos que a inserção do tendão do músculo grácil foi, em média, a 4,6 cm abaixo da superfície articular do joelho e a do semitendíneo foi, em média, a 7,4 cm. Existe correlação entre a estatura das pessoas e a localização destes tendões. Os músculos grácil e semitendíneo apresentam geralmente algum tipo de variação anatômica, sendo a mais frequente a inserção acessória do semitendíneo, 70%, e em segundo lugar a fusão entre eles, 56%.The crescent use of the tendons of the gracile and semitendinous muscles in knee ligament reconstruction procedures was accompanied by an increase of the number of complications originated by their removal, such as: tibial collateral ligament injury, saphenous nerve injury, wrong removal of the sartorio muscle tendon, the very section of the tendons, and increase of surgical procedure time due to inexperience or lack of knowledge of the knee medial region anatomy. (1-6) As the removal of such tendons has been a limiting factor in some orthopaedic procedures, we conducted this study by dissecting 30 cadaver knees, with the following purpose: to locate the insertion of the gracile and semitendinous muscles in the tibia; to check the correlation, if existent, between this location with the cadaver height and to evaluate the potential anatomical changes. We observed that the gracile muscle tendon insertion was, in average, at 4.6 cm below knee joint surface, and the semitendinous was, in average, at 7.4 cm. There is a correlation between people’s heights and the location of those tendons. Gracile and semitendinous muscles usually present some kind of anatomical change, with the semitendinous accessory insertion being the most frequent one, accounting for 70%, followed by the merge between them, which accounted for 56%.

Em 06/01/2003, foi publicada, em Mato Grosso do Sul, a Lei n. 2.605 estabelecendo as cotas para negros na Universidade Estadual de Mato Grosso do Sul – UEMS, sendo regulamentada para o vestibular do mesmo ano, com ingresso dos negros cotistas já no início de 2004. Passados nove anos de oferta, realizamos uma pesquisa no Mestrado em Educação/UEMS com o objetivo de avaliar os resultados gerais e específicos da presença dos negros cotistas nos quatro cursos de graduação em Direito, desvelando as conquistas e dificuldades enfrentadas no acesso e na permanência dos 47 (quarenta e sete) acadêmicos ingressantes em 2008. Para isso, utilizou-se a pesquisa qualitativa do tipo estudo de caso e fez-se uso de questionários semiestruturados. Os resultados gerais apontam para um índice considerável de desistência ou evasão dos negros cotistas pelas razões mais diversas e que serão analisadas neste trabalho.

The formation of Pd(0) in the absence of any classical reducing agent in a medium containing Mg2+/Al3+ layered double hydroxide (LDH) and N,N-dimethylformamide was evidenced. XRD analysis showed the presence of crystalline phases of palladium in the Pd/LDH composite. Suzuki-Miyaura reactions in aqueous medium were carried out at room temperature, and good yields were obtained with bromoarenes and iodoarenes using the ternary system LDH-Pd-CD (cyclodextrin) as catalyst.

Abstract The applicability of a numerical model following a downscaling methodology was evaluated for the south-eastern Brazilian shelf (regional model) and Paranaguá estuarine system (local model). This approach permits the simulation of different scale processes, such as storm surges and coastal upwelling, and is suitable for operational forecasting purposes. When large areas are covered by regional models, the tidal propagation inside the domain can be significantly affected by the local tidal potential, mainly where the resonance phenomenon is observed. The south-eastern Brazilian shelf is known for the resonance of the third-diurnal principal lunar tidal constituent (M3), the largest amplitudes being found in the Paranaguá estuarine system. Therefore, the significance of the local tidal potential was assessed in this study for the most important tidal constituents inside the estuarine system (including M3). The model validation was performed with tidal gauge data, Argo float profiles and satellite measurements of Sea Surface Temperature. The methodology described in this study can be replicated for other important estuarine systems located on the south-eastern Brazilian shelf. Furthermore, the numerical model was developed within a perspective of operational nowcast/forecast simulations, useful for several activities such as navigation and response to emergencies (e.g., oil spills).

Patients with cutaneous T-cell lymphoma with progressive disease typically undergo a series of skin-directed and systemic therapy regimens during cycles of response and relapse. Extracorporeal photopheresis (ECP) is an effective and safe systemic treatment option, often reserved for later stages of disease and typically employed after failure of several other therapies. ECP has benefits in response rate, time to next treatment, and tolerability that may support its use earlier in the treatment cycle for advancing/progressing disease., (© 2023 John Wiley & Sons Ltd.)

Options to prevent facial insect bites while sleeping are limited. Patients may prefer to avoid facial application of potentially neurotoxic insect repellants. Non-toxic &ldquo;natural&rdquo; repellants have limited efficacy, and netting may not be well-tolerated. Nightly facial application of 1% topical ivermectin (IVM) cream completely prevented overnight bites in 2 patients, both of whom reported recurrent bites after discontinuation, and a return to complete bite prevention after IVM resumption. Topical IVM may be an alternative facial mosquito bite prevention modality. J Drugs Dermatol. 2022;21(8):906-907. doi:10.36849/JDD.6432.

Dermatologists often recommend vitamin D for sun-protected patients. Most patients are not aware of the key role vitamin K2 plays in vitamin D metabolism and do not receive sufficient dietary vitamin K2. A survey of 50 sun-protecting patients shows 4/50 understood the role of vitamin K2 and 1/50 was supplementing vitamin K2. Therefore, counseling on vitamin K2 supplementation may be of benefit to sun-protected dermatology patients. J Drugs Dermatol. 2021;20(2):228-229. doi:10.36849/JDD.5829.

A carrier-based, immunogenic cell death (ICD)-eliciting platinum(IV) chemotherapeutic agent was synthesized via complexation between an axially derivatized Pt(IV)-tocopherol and hyaluronan (HA)-tocopherol nanocarrier. The resultant HA-Pt(IV) complex demonstrated antiproliferative activity and induced calreticulin translocation, an indicator of ICD, in murine and human head and neck cancer (HNC) cells. The intratumorally administered HA-Pt(IV) treatments were tolerable and efficacious in both immunocompetent and immunodeficient mice with HNC, partially because of the direct cytotoxicity. Superior efficacy and survival were observed in the immunocompetent group, suggesting a possible Pt(IV)-induced immunological response, which would only manifest in animals with an intact immune system. Subsequent imaging of tumor tissues demonstrated increased macrophage infiltration in the HA-Pt(IV)-treated tumors compared to the nontreated controls and the cisplatin-treated tumors, suggesting favorable inflammatory activation. RNA sequencing of HA-Pt(IV)-treated tumors indicated that carbohydrate and vitamin metabolisms were the most important Kyoto Encyclopedia of Genes and Genomes pathways, and molecular function, biological process, and cellular component were highly enriched gene ontology categories.

.

Background: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer., Case Presentation: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses. The adversereactions observed were acknowledged to be related to chronic hydroxyurea use. The patient underwent Mohs excision of the squamous cell carcinomas and thehydroxyurea was promptly discontinued; subsequent cutaneous improvement of the dermatomyositislike lesions ensued. Another clinically suspicious aggressive squamous cell carcinoma was suspected and the patient was referred to the plastic surgery department for complete excision because of the size of the lesion. The patient remains on periodic dermatology follow up., Conclusions: We report a case that exemplifies the cutaneous adverse effects of chronic hydroxyurea therapy. Although many cases improve after drug discontinuation, strict photoprotection and ongoing surveillance are indicated given the recently proposed premalignant potential of dermatomyositis-like eruptions and the aggressive nature of hydroxyurea-induced nonmelanoma skin cancer.

Paring is useful for both diagnosis and treatment of plantar warts. Paring techniques generally involve scalpel blades, abrasive tools, or curettes. However, these tools do not permit the use of an "awl-like" carving technique of the wart afforded by using a punch biopsy tool. We have found this technique to be associated with greater precision and safety, as well as potentially increased efficacy compared to traditional methods.

Introduction: Extracorporeal photopheresis (ECP) has been used for the treatment of advanced stage or treatment refractory cutaneous T-cell lymphoma (CTCL) since 1987, and more recently has also been shown to be of benefit for earlier stage resistant CTCL. Complete response rates in prior studies of ECP in early CTCL have ranged from 0% to 40%., Methods: We reviewed electronic medical records of all CTCL patients seen in the University of Kansas Cancer Center between June 2007 and May 2011. International review board approval was obtained. Inclusion criteria were (1) early stage CTCL and (2) ECP treatment. Data included demographics, type of intravenous access employed, CTCL subtype, cytogenetic features, adverse events, adjuvant treatments, and survival time in years. Treatment response was assessed via a modified severity weighted assessment tool (mSWAT). Primary outcome measures were response rates to ECP at 6 months and 12 months after beginning treatment., Results: Of 20 patients (13 female; 7 male), 7 were Stage 1A, 11 were 1B, and 2 were 2A. Seven patients with stable disease and 2 patients with progression at 6 months received adjuvant therapy (PUVA/systemic retinoids/metotrexate/interferon) in addition to ECP. Twelve-month response to ECP was 90%: 15 patients (75%) had complete responses, 3 (15%) had partial responses, 1 had stable disease, and 1 progressed., Conclusion: Used alone or in combination with adjuvant treatments, ECP can be an effective treatment method in early stage CTCL. , , J Drugs Dermatol. 2016;15(10):1212-1216.