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3. Temporal trends (1972–2017) and spatial differences of persistent halogenated aromatic hydrocarbons in osprey eggs in Finland.

Author

Viluksela, Matti, Saurola, Pertti, Koivusaari, Juhani, Finnlund, Matts, Bignert, Anders, Airaksinen, Riikka, Ruokojärvi, Päivi, Verta, Matti, Kiviranta, Hannu, Tuomisto, Jouni T., and Rantakokko, Panu

Subjects
EMISSIONS (Air pollution), POLYCHLORINATED naphthalenes, FORAGE fishes, POLYCHLORINATED biphenyls, POLYBROMINATED biphenyls, POLYCHLORINATED dibenzodioxins, DIOXINS
Abstract

Time trends and regional differences of polychlorinated dibenzo-p-dioxins and -furans (PCDD/Fs), polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs), DDTs, polybrominated biphenyls (PBBs) and polybrominated diphenylethers (BDEs) were studied in unhatched osprey eggs collected by bird ringers in 1972–2017 from four areas in Finland. Two study areas were from Baltic Sea, Northern Quark and Finnish Archipelago Sea, while the two others were inland lake areas, eutrophicated Lake Vanajanselkä affected by industrial emissions, and Pristine SW Lake Area. The highest concentrations of most compound groups were in Lake Vanajanselkä consistent with high emissions, the predominance of bream as a prey, and higher concentrations in bream compared to other prey fish. Concentrations of all chlorinated compounds decreased significantly in all study areas. Average annual decreases were ∑PCDD/F 2.3–4.9%, ∑PCB 2.2–4.2%, ∑PCN 2.6–7.0% and ∑DDT 7.1–9.5%, primarily in line with decreased levels in prey fish. From 1972 PBBs and BDEs increased significantly until 1990s declining rapidly thereafter. PCDD/F congener profile was dominated by 2,3,4,7,8-PeCDF, except in Lake Vanajanselkä by 1,2,3,6,7,8-HxCDD. PCB congener profile was dominated by PCB 153 in all study areas, followed by PCB 180 and PCB 138. Among dioxin-like compounds PCBs contributed 82%, PCDDs 14% and PCDFs 4% to toxic equivalent quantity (∑TEQ). PCB 126 contributed most to ∑TEQ, followed by 1,2,3,7,8-PeCDD. BDE 47 being the dominant BDE congener, followed by BDE 100. ∑DDT concentrations were relatively similar across all study areas, with DDE contributing about 90%. Productivity of chicks per active nest was significantly decreased in Lake Vanajanselkä, and the likely explanation is embryotoxicity of dioxin-like compounds. It is plausible that dioxin-like compounds influenced embryonic survival among highly exposed ospreys prior to 2010, especially in Lake Vanajanselkä and Northern Quark. However, decreased survival due to DDE-induced eggshell thinning seems unlikely after 1985, and BDE levels were below those potentially causing adverse effects. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Author

Vermeulen, Roel, Saberi Hosnijeh, Fatemeh, Bodinier, Barbara, Portengen, Lützen, Liquet, Benoît, Garrido-Manriquez, Javiera, Lokhorst, Henk, Bergdahl, Ingvar A, Kyrtopoulos, Soterios A, Johansson, Ann-Sofie, Georgiadis, Panagiotis, Melin, Beatrice, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Vineis, Paolo, Castagné, Raphaële, Chadeau-Hyam, Marc, Botsivali, Maria, Chatziioannou, Aristotelis, Valavanis, Ioannis, Kleinjans, Jos C S, de Kok, Theo M C M, Keun, Hector C, Athersuch, Toby J, Kelly, Rachel, Lenner, Per, Hallmans, Göran, Stephanou, Euripides G, Myridakis, Antonis, Kogevinas, Manolis, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Bendinelli, Benedetta, Kiviranta, Hannu, Rantakokko, Panu, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas, Tu, Yu-Kang, Lundh, Thomas, Chien, Kuo-Liong, Chen, Wei J, Lee, Wen-Chung, Kate Hsiao, Chuhsing, Kuo, Po-Hsiu, Hung, Hung, Liao, Shu-Fen, Vermeulen, Roel, Saberi Hosnijeh, Fatemeh, Bodinier, Barbara, Portengen, Lützen, Liquet, Benoît, Garrido-Manriquez, Javiera, Lokhorst, Henk, Bergdahl, Ingvar A, Kyrtopoulos, Soterios A, Johansson, Ann-Sofie, Georgiadis, Panagioti, Melin, Beatrice, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Vineis, Paolo, Castagné, Raphaële, Chadeau-Hyam, Marc, Botsivali, Maria, Chatziioannou, Aristoteli, Valavanis, Ioanni, Kleinjans, Jos C S, de Kok, Theo M C M, Keun, Hector C, Athersuch, Toby J, Kelly, Rachel, Lenner, Per, Hallmans, Goran, Stephanou, Euripides G, Myridakis, Antoni, Kogevinas, Manoli, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Bendinelli, Benedetta, Kiviranta, Hannu, Rantakokko, Panu, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thoma, Tu, Yu-Kang, Lundh, Thoma, Chien, Kuo-Liong, Chen, Wei J, Lee, Wen-Chung, Kate Hsiao, Chuhsing, Kuo, Po-Hsiu, Hung, Hung, Liao, Shu-Fen, One Health Chemisch, dIRAS RA-2, Sub Physical Oceanography, and Immunology

Subjects
Adult, Male, Vascular Endothelial Growth Factor A, multivariate model, prospective cohort, lymphoma, multivariate models, cytokine, Humans, Prospective Studies, Chemokine CCL7, Aged, Cancer och onkologi, mixed-effect modeling, Chemokine CX3CL1, Incidence, mixed‐effect modeling, Middle Aged, Transforming Growth Factor alpha, Prognosis, time to diagnosis, Europe, multiple myeloma, Case-Control Studies, Cancer and Oncology, Multivariate Analysis, Female, Fibroblast Growth Factor 2, Lymphoma, Large B-Cell, Diffuse, Biomarkers, Cancer Epidemiology, Follow-Up Studies
Abstract

Recent prospective studies have shown that dysregulation of the immune system may precede the development of B‐cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, which were considered separately. Using a nested case–control study within two European prospective cohorts, we measured plasma levels of 28 immune markers in samples collected a median of 6 years before diagnosis (range 2.01–15.97) in 268 incident cases of BCL (including multiple myeloma [MM]) and matched controls. Linear mixed models and partial least square analyses were used to analyze the association between levels of immune marker and the incidence of BCL and its main histological subtypes and to investigate potential biomarkers predictive of the time to diagnosis. Linear mixed model analyses identified associations linking lower levels of fibroblast growth factor‐2 (FGF‐2 p = 7.2 × 10−4) and transforming growth factor alpha (TGF‐α, p = 6.5 × 10−5) and BCL incidence. Analyses stratified by histological subtypes identified inverse associations for MM subtype including FGF‐2 (p = 7.8 × 10−7), TGF‐α (p = 4.08 × 10−5), fractalkine (p = 1.12 × 10−3), monocyte chemotactic protein‐3 (p = 1.36 × 10−4), macrophage inflammatory protein 1‐alpha (p = 4.6 × 10−4) and vascular endothelial growth factor (p = 4.23 × 10−5). Our results also provided marginal support for already reported associations between chemokines and diffuse large BCL (DLBCL) and cytokines and chronic lymphocytic leukemia (CLL). Case‐only analyses showed that Granulocyte‐macrophage colony stimulating factor levels were consistently higher closer to diagnosis, which provides further evidence of its role in tumor progression. In conclusion, our study suggests a role of growth‐factors in the incidence of MM and of chemokine and cytokine regulation in DLBCL and CLL., What's new? B‐cell lymphomas (BCL) are frequent in immunocompromised individuals, but most BCL cases are thought to occur as a consequence of minor immune perturbations in otherwise immunocompetent individuals. Here the authors prospectively examined a panel of immune markers in the blood from 268 patients afflicted with BCL and paired controls. The data uncover a functional role for growth factors (i.e. FGF‐2, TGF‐alpha) in the incidence and progression of multiple myeloma, a BCL subtype, and underscore the importance of chemokine and cytokine regulation in diffuse large B‐cell lymphoma and chronic lymphocytic leukemia.

Published
2018

14. DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

Author

Georgiadis, Panagiotis, Gavriil, Marios, Rantakokko, Panu, Ladoukakis, Efthymios, Botsivali, Maria, Kelly, Rachel S., Bergdahl, Ingvar A., Kiviranta, Hannu, Vermeulen, Roel C. H., Spaeth, Florentin, Hebbels, Dennie G. A. J., Kleinjans, Jos C. S., de Kok, Theo M. C. M., Palli, Domenico, Vineis, Paolo, Kyrtopoulos, Soterios A., Gottschalk, Ralph, van Leeuwen, Danitsja, Timmermans, Leen, Bendinelli, Benedetta, Portengen, Lutzen, Saberi-Hosnijeh, Fatemeh, Melin, Beatrice, Hallmans, Goran, Lenner, Per, Keun, Hector C., Siskos, Alexandros, Athersuch, Toby J., Kogevinas, Manolis, Stephanou, Euripides G., Myridakis, Antonis, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas, Tu, Yu-Kang, Jonsson, Bo, Lundh, Thomas, Chen, Wei J., Lee, Wen-Chung, Hsiao, Chuhsing Kate, Chien, Kuo-Liong, Kuo, Po-Hsiu, Hung, Hung, Liao, Shu-Fen, Toxicogenomics, RS: GROW - R1 - Prevention, RS: FSE MaCSBio, RS: FPN MaCSBio, RS: FHML MaCSBio, RS: MHeNs - R3 - Neuroscience, and Commission of the European Communities

Subjects
Male, EnviroGenomarkers consortium, HYPOMETHYLATION, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, Pathogenesis, Blood plasma, LYMPHOMA, skin and connective tissue diseases, lcsh:Environmental sciences, General Environmental Science, lcsh:GE1-350, RISK, 0303 health sciences, DNA methylation, ROLES, B-cell lymphoma, Melanoma, Persistent organic pollutants, Middle Aged, Polychlorinated Biphenyls, CANCER, 3. Good health, Italy, Molecular epidemiology, Female, Stem cell, Adult, GENES, POLYCOMB, Article, 03 medical and health sciences, Arbetsmedicin och miljömedicin, MD Multidisciplinary, medicine, Humans, Environmental toxicology, Gene, 030304 developmental biology, 0105 earth and related environmental sciences, Sweden, POLYCHLORINATED BIPHENYL EXPOSURES, Occupational Health and Environmental Health, medicine.disease, HYPERMETHYLATION, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, 13. Climate action, Cancer research, sense organs, Carcinogenesis, Hazard assessment, Environmental Sciences
Abstract

Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. Methods: We conducted an epigenome-wide association study on 611 adults free of diagnosed disease, living in Italy and Sweden, in whom we also measured plasma concentrations of 6 PCB congeners, DDE and hexachlorobenzene. Results: We identified 650 CpG sites whose methylation correlates strongly (FDR

Published
2019

15. Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Author

One Health Chemisch, dIRAS RA-2, Sub Physical Oceanography, Vermeulen, Roel, Saberi Hosnijeh, Fatemeh, Bodinier, Barbara, Portengen, Lützen, Liquet, Benoît, Garrido-Manriquez, Javiera, Lokhorst, Henk, Bergdahl, Ingvar A., Kyrtopoulos, Soterios A., Johansson, Ann Sofie, Georgiadis, Panagiotis, Melin, Beatrice, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Vineis, Paolo, Castagné, Raphaële, Chadeau-Hyam, Marc, Botsivali, Maria, Chatziioannou, Aristotelis, Valavanis, Ioannis, Kleinjans, Jos C.S., de Kok, Theo M.C.M., Keun, Hector C., Athersuch, Toby J., Kelly, Rachel, Lenner, Per, Hallmans, Goran, Stephanou, Euripides G., Myridakis, Antonis, Kogevinas, Manolis, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Bendinelli, Benedetta, Kiviranta, Hannu, Rantakokko, Panu, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas, Tu, Yu Kang, Lundh, Thomas, Chien, Kuo Liong, Chen, Wei J., Lee, Wen Chung, Kate Hsiao, Chuhsing, Kuo, Po Hsiu, Hung, Hung, Liao, Shu Fen, One Health Chemisch, dIRAS RA-2, Sub Physical Oceanography, Vermeulen, Roel, Saberi Hosnijeh, Fatemeh, Bodinier, Barbara, Portengen, Lützen, Liquet, Benoît, Garrido-Manriquez, Javiera, Lokhorst, Henk, Bergdahl, Ingvar A., Kyrtopoulos, Soterios A., Johansson, Ann Sofie, Georgiadis, Panagiotis, Melin, Beatrice, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Vineis, Paolo, Castagné, Raphaële, Chadeau-Hyam, Marc, Botsivali, Maria, Chatziioannou, Aristotelis, Valavanis, Ioannis, Kleinjans, Jos C.S., de Kok, Theo M.C.M., Keun, Hector C., Athersuch, Toby J., Kelly, Rachel, Lenner, Per, Hallmans, Goran, Stephanou, Euripides G., Myridakis, Antonis, Kogevinas, Manolis, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Bendinelli, Benedetta, Kiviranta, Hannu, Rantakokko, Panu, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas, Tu, Yu Kang, Lundh, Thomas, Chien, Kuo Liong, Chen, Wei J., Lee, Wen Chung, Kate Hsiao, Chuhsing, Kuo, Po Hsiu, Hung, Hung, and Liao, Shu Fen

Published
2018

16. Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Author

Chatziioannou, Aristotelis, Georgiadis, Panagiotis, Hebels, Dennie G, Liampa, Irene, Valavanis, Ioannis, Bergdahl, Ingvar A, Johansson, Anders, Palli, Domenico, Chadeau-Hyam, Marc, Siskos, Alexandros P., Keun, Hector, Botsivali, Maria, de Kok, Theo M C M, Pérez, Almudena Espín, Kleinjans, Jos C S, Vineis, Paolo, Kyrtopoulos, Soterios A, Gottschalk, Ralph, Van Leeuwen, Danitsja, Timmermans, Leen, Bendinelli, Benedetta, Kelly, Rachel S., Vermeulen, Roel, Portengen, Lutzen, Saberi-Hosnijeh, Fatemeh, Melin, Beatrice, Hallmans, Goran, Lenner, Per, Athersuch, Toby J., Kogevinas, Manolis, Stephanou, Euripides G., Myridakis, Antonis, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Kiviranta, Hannu, Rantakokko, Panu, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas D, Tu, Yu Kang, Jonsson, Bo A. G., Lundh, Thomas, Chen, Wei J., Lee, Wen Chung, Hsiao, Chuhsing Kate, Chien, Kuo Liong, Kuo, Po Hsiu, Hung, Hung, Liao, Shu Fen, LS IRAS EEPI GRA (Gezh.risico-analyse), Sub IRAS EEPI Algemeen, LS Knijn, dIRAS RA-2, CBITE, RS: MERLN - Cell Biology - Inspired Tissue Engineering (CBITE), Toxicogenomics, RS: GROW - R1 - Prevention, RS: FHML MaCSBio, RS: FPN MaCSBio, RS: FSE MaCSBio, and Promovendi ODB

Subjects
0301 basic medicine, Adult, Epigenomics, Male, SEX-DIFFERENCES, PLATELET ACTIVATION, Disease, Biology, OBSTRUCTIVE PULMONARY-DISEASE, Article, Epigenesis, Genetic, Transcriptome, 03 medical and health sciences, LUNG-CANCER, Sex Factors, RISK-FACTOR, Humans, Cardiac and Cardiovascular Systems, CORONARY-HEART-DISEASE, Gene Regulatory Networks, Platelet activation, Epigenetics, GENE-EXPRESSION, Aged, Regulation of gene expression, Kardiologi, Science & Technology, Multidisciplinary, Gene Expression Profiling, Public Health, Global Health, Social Medicine and Epidemiology, DNA Methylation, Middle Aged, Multidisciplinary Sciences, Gene expression profiling, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, 030104 developmental biology, MYOCARDIAL-INFARCTION, Gene Expression Regulation, Cardiovascular Diseases, DNA methylation, Immunology, Science & Technology - Other Topics, CpG Islands, Female, Tobacco Smoke Pollution, CIGARETTE-SMOKING, HEME OXYGENASE-1
Abstract

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.

Published
2017
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18. Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), Sub IRAS EEPI Algemeen, LS Knijn, dIRAS RA-2, Chatziioannou, Aristotelis, Georgiadis, Panagiotis, Hebels, Dennie G, Liampa, Irene, Valavanis, Ioannis, Bergdahl, Ingvar A, Johansson, Anders, Palli, Domenico, Chadeau-Hyam, Marc, Siskos, Alexandros P., Keun, Hector, Botsivali, Maria, de Kok, Theo M C M, Pérez, Almudena Espín, Kleinjans, Jos C S, Vineis, Paolo, Kyrtopoulos, Soterios A, Gottschalk, Ralph, Van Leeuwen, Danitsja, Timmermans, Leen, Bendinelli, Benedetta, Kelly, Rachel S., Vermeulen, Roel, Portengen, Lutzen, Saberi-Hosnijeh, Fatemeh, Melin, Beatrice, Hallmans, Goran, Lenner, Per, Athersuch, Toby J., Kogevinas, Manolis, Stephanou, Euripides G., Myridakis, Antonis, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Kiviranta, Hannu, Rantakokko, Panu, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas D, Tu, Yu Kang, Jonsson, Bo A. G., Lundh, Thomas, Chen, Wei J., Lee, Wen Chung, Hsiao, Chuhsing Kate, Chien, Kuo Liong, Kuo, Po Hsiu, Hung, Hung, Liao, Shu Fen, LS IRAS EEPI GRA (Gezh.risico-analyse), Sub IRAS EEPI Algemeen, LS Knijn, dIRAS RA-2, Chatziioannou, Aristotelis, Georgiadis, Panagiotis, Hebels, Dennie G, Liampa, Irene, Valavanis, Ioannis, Bergdahl, Ingvar A, Johansson, Anders, Palli, Domenico, Chadeau-Hyam, Marc, Siskos, Alexandros P., Keun, Hector, Botsivali, Maria, de Kok, Theo M C M, Pérez, Almudena Espín, Kleinjans, Jos C S, Vineis, Paolo, Kyrtopoulos, Soterios A, Gottschalk, Ralph, Van Leeuwen, Danitsja, Timmermans, Leen, Bendinelli, Benedetta, Kelly, Rachel S., Vermeulen, Roel, Portengen, Lutzen, Saberi-Hosnijeh, Fatemeh, Melin, Beatrice, Hallmans, Goran, Lenner, Per, Athersuch, Toby J., Kogevinas, Manolis, Stephanou, Euripides G., Myridakis, Antonis, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Kiviranta, Hannu, Rantakokko, Panu, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas D, Tu, Yu Kang, Jonsson, Bo A. G., Lundh, Thomas, Chen, Wei J., Lee, Wen Chung, Hsiao, Chuhsing Kate, Chien, Kuo Liong, Kuo, Po Hsiu, Hung, Hung, and Liao, Shu Fen

Published
2017

19. Additional file 4: Table S4. of Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study

Author

Rantakokko, Panu, Männistö, Ville, Airaksinen, Riikka, Koponen, Jani, Viluksela, Matti, Kiviranta, Hannu, and Pihlajamäki, Jussi

Subjects
body regions, nervous system, genetic structures, fungi, behavioral disciplines and activities
Abstract

Associations of ALT with POPs at baseline and at 12 months stratified by sex. (PDF 165 kb)

Published
2015
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21. PRESENCE OF THE ALA ALLELE IN THE PPAR-GAMMA GENE IS NOT PROTECTIVE AGAINST RISK OF IMPAIRED GLUCOSE METABOLISM ASSOCIATED WITH POP EXPOSURE

Author

Rantakokko Panu, Airaksinen Riikka, Kajantie Eero, Osmond Clive, Kiviranta Hannu, and Eriksson Johan G

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Peroxisome proliferator-activated receptor gamma, business.industry, Peroxisome proliferator-activated receptor, Type 2 diabetes, Peroxisome, Carbohydrate metabolism, medicine.disease, Endocrinology, chemistry, Internal medicine, Diabetes mellitus, General Earth and Planetary Sciences, Medicine, Allele, business, Gene, General Environmental Science
Abstract

BACKGROUND Exposure to persistent organic pollutants (POPs) is associated with type 2 diabetes. Presence of the Ala allele in the peroxisome proliferator-activated receptor-gamma (PPARG) gene has b...

Published
2013
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22. Itämeren kalan ja muun kotimaisen kalan ympäristömyrkyt: PCDD/F-, PCB-, PBDE-, PFC- ja OT-yhdisteet : EU-kalat II

Author

Hallikainen, Anja, Airaksinen, Riikka, Rantakokko, Panu, Koponen, Jani, Mannio, Jaakko, Vuorinen, Pekka J., Jääskeläinen, Timo, and Kiviranta, Hannu

Subjects
Itämeri, orgaaniset tinayhdisteet, ympäristömyrkyt
Abstract

EU-KALAT II hankkeessa tuotettiin tietoa Itämeren kalojen ja kotimaisten järvikalojen sekä kasvatettujen kalojen PCDD/F- ja PCB- sekä PBDE-pitoisuuksista eri ikäisissä ja kokoisissa kaloissa sekä lajeittain että alueittain. Hankkeessa tutkittiin myös perfluorattuja yhdisteitä (PFC) ja organotina (OT)-yhdisteitä sekä lihaksesta että maksasta. Tutkimuksesta saatiin uutta tietoa kalojen haitallisten aineiden pitoisuuksista riskinhallintaa varten. Vuoden 2009 tuloksia verrattiin aikaisempiin tuloksiin vuosilta 2002-2003. Itämeren ja muun kotimaisen kalan PCDD/F- ja PCB-pitoisuuksista nousevat esiin samat kalalajit, joiden on aiemminkin todettu keräävän näitä ympäristömyrkkyjä. Silakka, lohi ja meritaimen sekä nahkiainen ja tässä hankkeessa lisäksi kampela Kotkan alueelta ylittävät PCDD/F- ja PCB-yhdisteille asetetut enimmäispitoisuusrajat. Itämeren kaloista, kilohailin, muikun, ahvenen, hauen, kuhan, mateen ja turskan dioksiinien mediaanipitoisuudet eivät yllä edes puoleen sallitusta enimmäispitoisuudesta, joka on 4 pg/g tuorepainoa. Kun verrataan vuoden 2002-2003 pitoisuuksia vuoden 2009 PCDD/F- ja PCB- sekä PBDE-yhdisteiden pitoisuuksiin, ovat lohen ja silakan keskimääräiset pitoisuudet pienentyneet. Avomerialueiden OT-pitoisuudet lihaksessa olivat noin kolmanneksen pienemmät kuin vuonna 2005–2007 pyydetyissä näytteissä. Pahimpia Itämeren ympäristömyrkkyjä ovat edelleen dioksiinit ja dioksiininkaltaiset PCB-yhdisteet. PBDE- ja PFOS- ja OTpitoisuudet ovat pieniä muutamaa poikkeusta lukuun ottamatta. Useista kalalajeista suurimmat haitta-aineiden pitoisuudet todettiin seuraavilta alueilta: Selkämereltä Porin edusta ja Turun ja Kotkan pyyntialueet sekä kaikkein pahimpana Helsingin Vanhankaupunginlahti, jossa sekä OT- että PFOS-pitoisuudet antavat aihetta suositella kulutuksen rajoittamista, ainakin isojen ahventen osalta. As an outcome of the EU FISH II project, information was produced about PCDD/F and PCB as well as PBDE levels in Baltic fish, domestic freshwater fish and farmed fish. Variations in the levels were studied by age and size of the fish as well as by species and areas. Analyses of the presence of perfluorinated compounds (PFC) and organotin compounds (OT) in muscles and liver were also carried out within the scope of the project. New data on the content of hazardous substances in fish were obtained for use in risk management. The 2009 results were compared with the results of the previous project conducted in 2002-2003. Analyses of PCDD/F and PCB levels in fish highlight the same species that have also previously been found to be susceptible to accumulation of these environmental toxins. Baltic herring, salmon and sea trout as well as river lamprey and now in this study also European flounder in Kotka area show levels of PCDD/F and PCB compounds exceeding the maximum stipulated limits. In Baltic fish, the median levels of dioxin equivalents in sprat, vendace, perch, pike, pike-perch, burbot and cod are not even half of the permitted maximum level, which is 4 pg/g of fresh weight. The comparison of the levels measured in 2002-2003 with the 2009 levels of PCDD/F and PCB as well as PBDE compounds shows that the mean levels have decreased in salmon and herring. The OT levels measured in the muscles of open sea fish were about one third lower than in the fish samples caught in 2005–2007. Dioxins and dioxin-like PCB compounds are still the worst contaminants in the Baltic Sea. The levels of PBDE, PFOS and OT were low, with a few exceptions. The Bothnian Sea and the fishing areas of Pori, Turku and Kotka took the lead in the contamination ranking, but the worst area was Vanhankaupunginlahti Bay of Helsinki, where both OT and PFOS levels give cause to recommend consumption restrictions, at least as far as large perch are concerned. I projektet EU-FISK II producerades information om PCDD/F- och PCBjämte PBDE-halterna i östersjöfisk och inhemsk insjöfisk och odlad fisk av olika ålder och storlek såväl artvis som regionvis. I projektet undersöktes också såväl muskler som levern med tanke på perfluorkolväten (PFC) som organiska tennföreningar (OT). Undersökningen gav ny information om halterna skadliga ämnen i fisk med tanke på riskhanteringen. Resultaten från år 2009 jämfördes med de tidigare resultaten från åren 2002-2003. I fråga om PCDD/F- och PCB-halterna i östersjöfisk och annan inhemsk fisk framhävs samma fiskarter som också tidigare kontaterats samla på sig av dessa miljötoxiner. Strömming, lax och havsöring jämte nejonöga och i detta projekt också flundra från Kotkaområdet överskred gränsvärdena som fastställts för PCDD/F- och PCB-föreningar. Av östersjöfisken når medianhalterna dioxinekvivalenter i skarpsill, siklöja, abborre, gädda, gös, lake och torsk inte ens upp till halva det tillåtna gränsvärdet, som är 4 pg/g färskvikt. Då man jämför halterna år 2002-2003 med halterna PCDD/F- och PCB- jämte PBDE-föreningar år 2009, har de genomsnittliga halterna i lax och strömming minskat. OT-halterna i muskler i fisk från öppet havar är cirka en tredjedel mindre än i proverna från fisk som fångats år 2005–2007. Dioxinerna och de dioxinliknande PCB-föreningarna utgör fortsättningsvis de värsta kontaminanterna i Östersjön. PBDE-, PFOS- och OT-halterna var med några få undantag små. Som mest kontaminerade framstod fiskeriområdena Bottenhavet, Björneborg, Åbo och Kotka och som det allra värsta området Gammelstadsviken i Helsingfors, där såväl OT- som PFOS-halterna ger orsak att rekommendera en begränsing av konsumtionen åtminstone för stora abborrars del.

Published
2011

26. Orgaanisten tinayhdisteiden pitoisuudet Itämeren kalassa ja kotimaisessa järvikalassa

Author

Hallikainen, Anja, Airaksinen, Riikka, Rantakokko, Panu, Vuorinen, Pekka J., Mannio, Jaakko, Lappalainen, Antti, Vihervuori, Aune, and Vartiainen, Terttu

Subjects
kala, laivanpohjamaalit, sedimentti, orgaaniset tinayhdisteet, Itämeri, vesi, sedimentit, saastuneet ja tausta-alueet
Abstract

Orgaanisten tinayhdisteiden (OT) pitoisuuksia kotimaisessa meri- ja järvikalassa alettiin tutkia kattavasti, kun Helsingin uuden suursataman rakentamisen yhteydessä vuonna 2005 mitattiin kalasta ja sedimentistä suuria OT-pitoisuuksia. Tutkimuksessa keskityttiin niihin sisävesi- ja merikaloihin, joita suomalaiset pääsääntöisesti käyttävät ravinnokseen. Näytteitä kerättiin sekä kuormitetuilta satama- ja teollisuusalueilta että alueilta, joilla ei ole paikallista kuormitusta. Sisävesillä kalojen OT-pitoisuudet jäivät yleensä alle 10 μg/kg tuorepaino (tp), mutta neljällä paikkakunnalla (Varkaus, Lohja, Jyväskylä ja Tampere) pitoisuudet olivat 19–28 μg/kg. Varkauden Huruslahden sedimentistä mitattiin hankkeen yhteydessä 2–6 cm:n syvyydeltä jopa 35000 μg/kg kuivapaino (kp) pitoisuus. Merialueiden kaloissa OT-pitoisuudet olivat noin 10 kertaa suurempia kuin sisävesillä. Merialueilla, joilla ei ole paikallista kuormitusta, OT-pitoisuudet kaloissa olivat alle 20 μg/kg tp. Kuormitetuilla alueilla pitoisuudet ylittivät 40 μg/kg. Pahasti saastuneilta alueilta löydettiin 150–500 μg/kg pitoisuuksia. Suurimmat OT-pitoisuudet todettiin Helsingin Vanhankaupunginlahden ahvenista (28–528 μg/kg), joilla sekä pituus että paino korreloivat OT-pitoisuuden kanssa. Suuria pitoisuuksia todettiin myös Naantalin satamassa, jossa pitoisuudet kuitenkin pienenivät nopeasti avomerelle siirryttäessä. OT-pitoisuudet vaihtelivat samoilta pyyntialueilta kerättyjen kalalajien välillä. Ahvenesta, lahnasta ja kuhasta, jotka viihtyvät saaristossa ja sisälahdissa, mitattiin keskimäärin suurempia pitoisuuksia kuin silakasta, lohesta ja kilohailista, jotka viihtyvät lähinnä avomerellä. Man beslöt undersöka halterna organiska tennföreningar (OT) i inhemsk havs- och insjöfisk på bred front då stora OT-halter i fisk och sediment uppmättes år 2005 i samband med byggandet av den nya storhamnen i Helsingfors. I undersökningen koncentrerade man sig på sådan insjö- och havsfisk, som finländare i regel använder som föda. Prover samlades in såväl i belastade hamn- och industriområden som i områden utan lokal belastning. I insjövatten stannade OT-halterna i fisk i allmänhet under 10 μg/kg färsk vikt (fv), men på fyra orter (Varkaus, Lojo, Jyväskylä och Tammerfors) var halterna 19–28 μg/kg. I sedimentet i Huruslahti i Varkaus uppmättes i samband med projektet på 2–6 cm djup halter på hela 35000 μg/kg (torrvikt). I fisk i havsområden var OT-halterna cirka 10 gånger högre än i insjöfisk. I havsområden utan lokal belastning var OT-halterna i fisk under 20 μg/kg fv. I belastade områden översteg halterna 40 μg/kg. I svårt förorenade områden påträffades halter på 150–500 μg/kg. De högsta OT-halterna påträffades i abborrar i Gammelstadsviken i Helsingfors (28–528 μg/kg), hos vilka såväl längden som vikten korrelerade med OT-halten. Höga halter påträffades också i hamnen i Nådendal, där de ändå snabbt sjönk allt efter som man förflyttade sig längre ut mot öppet hav. OT-halterna varierade mellan fiskar insamlade i samma fångstområden. Hos abborre, braxen och gös som trivs i skärgården och innervikar uppmättes i genomsnitt högre halter än hos strömming, lax och vassbuk som främst trivs i öppet hav. The decision to launch an extensive study on the levels of organic tin compounds (OTC) in Finnish fresh water and sea fish was made when high levels of OTC were found in fish and in the sediment in connection with the construction project of the new harbour in Helsinki in 2005. The study focused on the fresh water and sea fish species that Finns mainly use as food. Samples were collected both in harbour and industrial areas with OTC contamination and in areas with no local contamination. OTC content in fresh water fish usually remained under 10 μg/kg fresh weight (fw), but contents measured in four municipalities (Varkaus, Lohja, Jyväskylä and Tampere) were 19–28 μg/kg. OTC content of as high as 35,000 μg/kg (dry weight) was measured in the sediment in Huruslahti Bay, Varkaus, at the depth of 2–6 cm. Sea fish showed OTC levels about ten times higher than fresh water areas. OTC content in fish was under 20 μg/kg fw in sea areas with no local contamination. Contents in contaminated areas exceeded 40 μg/kg. Contents of 150–500 μg/kg were found in severely contaminated areas. The highest OTC contents (28–528 μg/kg) were found in perch caught in Vanhankaupunginlahti Bay in Helsinki. In this case, both the length and weight of fish correlated with the OTC content. High OTC levels were also found in the Naantali Harbour where the level decreased rapidly when moving towards the open sea. The OTC levels in fish caught in the same area varied between different species. Levels found in perch, bream and pike-perch, the preferred habitats of which are in the archipelago and inland bays, were on average higher than levels found in herring, salmon and sprat, which live in the open sea.

Published
2008

27. Association of placenta organotin concentrations with growth and ponderal index in 110 newborn boys from Finland during the first 18 months of life: a cohort study

Author

Rantakokko, Panu, primary, Main, Katharina M, additional, Wohlfart-Veje, Christine, additional, Kiviranta, Hannu, additional, Airaksinen, Riikka, additional, Vartiainen, Terttu, additional, Skakkebæk, Niels E, additional, Toppari, Jorma, additional, and Virtanen, Helena E, additional

Published
2014
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28. Itämeren kalan ja muun kotimaisen kalan ympäristömyrkyt: PCDD/F-, PCB-, PBDE-, PFC- ja OT-yhdisteet

Author

Hallikainen, Anja, Airaksinen, Riikka, Rantakokko, Panu, Koponen, Jani, Mannio, Jaakko, Vuorinen, Pekka J., Jääskeläinen, Timo, Kiviranta, Hannu, Hallikainen, Anja, Airaksinen, Riikka, Rantakokko, Panu, Koponen, Jani, Mannio, Jaakko, Vuorinen, Pekka J., Jääskeläinen, Timo, and Kiviranta, Hannu

Abstract

EU-KALAT II hankkeessa tuotettiin tietoa Itämeren kalojen ja kotimaisten järvikalojen sekä kasvatettujen kalojen PCDD/F- ja PCB- sekä PBDE-pitoisuuksista eri ikäisissä ja kokoisissa kaloissa sekä lajeittain että alueittain. Hankkeessa tutkittiin myös perfluorattuja yhdisteitä (PFC) ja organotina (OT)-yhdisteitä sekä lihaksesta että maksasta. Tutkimuksesta saatiin uutta tietoa kalojen haitallisten aineiden pitoisuuksista riskinhallintaa varten. Vuoden 2009 tuloksia verrattiin aikaisempiin tuloksiin vuosilta 2002-2003. Itämeren ja muun kotimaisen kalan PCDD/F- ja PCB-pitoisuuksista nousevat esiin samat kalalajit, joiden on aiemminkin todettu keräävän näitä ympäristömyrkkyjä. Silakka, lohi ja meritaimen sekä nahkiainen ja tässä hankkeessa lisäksi kampela Kotkan alueelta ylittävät PCDD/F- ja PCB-yhdisteille asetetut enimmäispitoisuusrajat. Itämeren kaloista, kilohailin, muikun, ahvenen, hauen, kuhan, mateen ja turskan dioksiinien mediaanipitoisuudet eivät yllä edes puoleen sallitusta enimmäispitoisuudesta, joka on 4 pg/g tuorepainoa. Kun verrataan vuoden 2002-2003 pitoisuuksia vuoden 2009 PCDD/F- ja PCB- sekä PBDE-yhdisteiden pitoisuuksiin, ovat lohen ja silakan keskimääräiset pitoisuudet pienentyneet. Avomerialueiden OT-pitoisuudet lihaksessa olivat noin kolmanneksen pienemmät kuin vuonna 2005–2007 pyydetyissä näytteissä. Pahimpia Itämeren ympäristömyrkkyjä ovat edelleen dioksiinit ja dioksiininkaltaiset PCB-yhdisteet. PBDE- ja PFOS- ja OTpitoisuudet ovat pieniä muutamaa poikkeusta lukuun ottamatta. Useista kalalajeista suurimmat haitta-aineiden pitoisuudet todettiin seuraavilta alueilta: Selkämereltä Porin edusta ja Turun ja Kotkan pyyntialueet sekä kaikkein pahimpana Helsingin Vanhankaupunginlahti, jossa sekä OT- että PFOS-pitoisuudet antavat aihetta suositella kulutuksen rajoittamista, ainakin isojen ahventen osalta., As an outcome of the EU FISH II project, information was produced about PCDD/F and PCB as well as PBDE levels in Baltic fish, domestic freshwater fish and farmed fish. Variations in the levels were studied by age and size of the fish as well as by species and areas. Analyses of the presence of perfluorinated compounds (PFC) and organotin compounds (OT) in muscles and liver were also carried out within the scope of the project. New data on the content of hazardous substances in fish were obtained for use in risk management. The 2009 results were compared with the results of the previous project conducted in 2002-2003. Analyses of PCDD/F and PCB levels in fish highlight the same species that have also previously been found to be susceptible to accumulation of these environmental toxins. Baltic herring, salmon and sea trout as well as river lamprey and now in this study also European flounder in Kotka area show levels of PCDD/F and PCB compounds exceeding the maximum stipulated limits. In Baltic fish, the median levels of dioxin equivalents in sprat, vendace, perch, pike, pike-perch, burbot and cod are not even half of the permitted maximum level, which is 4 pg/g of fresh weight. The comparison of the levels measured in 2002-2003 with the 2009 levels of PCDD/F and PCB as well as PBDE compounds shows that the mean levels have decreased in salmon and herring. The OT levels measured in the muscles of open sea fish were about one third lower than in the fish samples caught in 2005–2007. Dioxins and dioxin-like PCB compounds are still the worst contaminants in the Baltic Sea. The levels of PBDE, PFOS and OT were low, with a few exceptions. The Bothnian Sea and the fishing areas of Pori, Turku and Kotka took the lead in the contamination ranking, but the worst area was Vanhankaupunginlahti Bay of Helsinki, where both OT and PFOS levels give cause to recommend consumption restrictions, at least as far as large perch are concerned., I projektet EU-FISK II producerades information om PCDD/F- och PCBjämte PBDE-halterna i östersjöfisk och inhemsk insjöfisk och odlad fisk av olika ålder och storlek såväl artvis som regionvis. I projektet undersöktes också såväl muskler som levern med tanke på perfluorkolväten (PFC) som organiska tennföreningar (OT). Undersökningen gav ny information om halterna skadliga ämnen i fisk med tanke på riskhanteringen. Resultaten från år 2009 jämfördes med de tidigare resultaten från åren 2002-2003. I fråga om PCDD/F- och PCB-halterna i östersjöfisk och annan inhemsk fisk framhävs samma fiskarter som också tidigare kontaterats samla på sig av dessa miljötoxiner. Strömming, lax och havsöring jämte nejonöga och i detta projekt också flundra från Kotkaområdet överskred gränsvärdena som fastställts för PCDD/F- och PCB-föreningar. Av östersjöfisken når medianhalterna dioxinekvivalenter i skarpsill, siklöja, abborre, gädda, gös, lake och torsk inte ens upp till halva det tillåtna gränsvärdet, som är 4 pg/g färskvikt. Då man jämför halterna år 2002-2003 med halterna PCDD/F- och PCB- jämte PBDE-föreningar år 2009, har de genomsnittliga halterna i lax och strömming minskat. OT-halterna i muskler i fisk från öppet havar är cirka en tredjedel mindre än i proverna från fisk som fångats år 2005–2007. Dioxinerna och de dioxinliknande PCB-föreningarna utgör fortsättningsvis de värsta kontaminanterna i Östersjön. PBDE-, PFOS- och OT-halterna var med några få undantag små. Som mest kontaminerade framstod fiskeriområdena Bottenhavet, Björneborg, Åbo och Kotka och som det allra värsta området Gammelstadsviken i Helsingfors, där såväl OT- som PFOS-halterna ger orsak att rekommendera en begränsing av konsumtionen åtminstone för stora abborrars del.

Published
2011

33. Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study

Author

Kelly, Rachel S., Kiviranta, Hannu, Bergdahl, Ingvar A., Palli, Domenico, Johansson, Ann-Sofie, Botsivali, Maria, Vineis, Paolo, Vermeulen, Roel, Kyrtopoulos, Soterios A., Chadeau-Hyam, Marc, Keun, Hector C., Athersuch, Toby J., vanVeldhoven, Karin, Jonsson, Bo, Melin, Beatrice, Lenner, Per, Georgiadis, Panagiotis, Papadopoulou, Christina, Chatziioannou, Aristotelis, Valavanis, Ioannis, Sacerdote, Carlotta, Portengen, Lützen, Saberi-Hosnijeh, Fatemeh, Hebels, Dennie G. A. J., Kleinjans, Jos C. S., de Kok, Theo M. C. M., Gottschalk, Ralph, van Leeuwen, Danitsja, Timmermans, Leen, Hallmans, Göran, Bendinelli, Benedetta, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Kogevinas, Manolis, Stephanou, Euripides G., Myridakis, Antonis, Fazzo, Lucia, De Santis, Marco, Comba, Pietro, Rantakokko, Panu, Airaksinen, Riikka, Ruokojärvi, Päivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas, Tu, Yu-Kang, Chen, Wei J., Lee, Wen-Chung, Hsiao, Chuhsing Kate, Chien, Kuo-Liong, Kuo, Po-Hsiu, Hung, Hung, Liao, Shu-Fen, and Lundh, Thoma

Subjects
Non Hodgkin lymphoma, Polychlorinated biphenyls, DDE, HCB, Organochlorines, EnviroGenoMarkers
Abstract

Background: Evidence suggests a largely environmental component to non-Hodgkin’s lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to be determined. Methods: The EnviroGenoMarkers study is nested within two prospective cohorts EPIC-Italy and the Northern Sweden Health and Disease Study. Six PCB congeners, DDE and HCB were measured in blood plasma samples provided at recruitment using gas-chromatography mass spectrometry. During 16 years follow-up 270 incident cases of B-cell NHL (including 76 cases of multiple myeloma) were diagnosed. Cases were matched to 270 healthy controls by centre, age, gender and date of blood collection. Cases were categorised into ordered quartiles of exposure for each POP based on the distribution of exposure in the control population. Logistic regression was applied to assess the association with risk, multivariate and stratified analyses were performed to identify confounders or effect modifiers. Results: The exposures displayed a strong degree of correlation, particularly amongst those PCBs with similar degrees of chlorination. There was no significant difference (p < 0.05) in median exposure levels between cases and controls for any of the investigated exposures. However under a multivariate model PCB138, PCB153, HCB and DDE displayed significant inverse trends (Wald test p-value <0.05). Under stratified analyses these were determined to be driven by males and by the Diffuse Large B-Cell Lymphoma subtype. When considering those in the highest levels of exposure (>90th percentile) the association was null for all POPs Conclusion: We report no evidence that a higher body burden of PCBs, DDE or HCB increased the risk of subsequent NHL diagnosis. Significantly inverse associations were noted for males with a number of the investigated POPs. We hypothesize these unexpected relationships may relate to the subtype composition of our population, effect modification by BMI or other unmeasured confounding. This study provides no additional support for the previously observed role of PCBs, DDE and HCB as risk factors for NHL. Electronic supplementary material The online version of this article (doi:10.1186/s12940-017-0214-8) contains supplementary material, which is available to authorized users.

Published
2017
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34. Blood concentration of methylmercury in relation to food consumption.

Author

Airaksinen, Riikka, Turunen, Anu W, Rantakokko, Panu, Männistö, Satu, Vartiainen, Terttu, and Verkasalo, Pia K

Subjects
*FISH as food, *METHYLMERCURY, *MERCURY content of fish, *BLOOD testing, *FOOD consumption, *RISK assessment, *FOOD habits, *FISHERS
Abstract

ObjectiveDietary fish is the main source of methylmercury (MeHg) for man, and fish consumption has been used as a measure of MeHg exposure. However, other dietary sources of exposure exist and MeHg metabolism may also be modified by nutritional factors. The aim of the present study was to examine the association between blood MeHg concentration and consumption of different foods in a Finnish population with high fish consumption.DesignBlood samples, a detailed FFQ and additional frequency data on fish consumption were collected. MeHg was analysed from whole blood by the isotope dilution method with high-resolution MS. The consumption of different foods was calculated by MeHg quartiles and tested for linear trend.SettingFinnish southern and south-western coast of the Baltic Sea.SubjectsTwo hundred and ninety-nine professional fishermen, their spouses and other family members.ResultsMean (range) blood MeHg concentration was 4·6 (0·21–22) μg/l among men and 2·8 (<0·15–20) μg/l among women. Fish had the strongest positive association with MeHg (P for linear trend <0·001 among both men and women). Among men, positive associations were also observed for fruit vegetables, wheat and wine. Among women, positive associations were observed for root vegetables, legumes, potato and game, but adjustment for fish consumption attenuated these trends.ConclusionsThe study shows that, besides fish, MeHg may have other dietary sources that should be taken into account in risk assessment studies. Due to the observed high blood MeHg concentration, a thorough exposure assessment among the general Finnish population is recommended. [ABSTRACT FROM AUTHOR]

Published
2011
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40. Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Author

Vermeulen, Roel C. H., Saberi Hosnijeh, Fatemeh, Bodinier, Barbara, Portengen, Lützen, Liquet, Benoît, Garrido Manriquez, Javiera, Lokhorst, Henk, Bergdahl, Ingvar A., Kyrtopoulos, Soterios, Johansson, Ann-Sofie, Georgiadis, Panagiotis, Melin, Beatrice S., Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Vineis, Paolo, Castagné, Raphaele, Chadeau-Hyam, Marc, EnviroGenoMarkers Consortium, Botsivali, Maria, Chatziioannou, Aristotelis, Valavanis, Ioannis, Kleinjans, Jos C. S., Kok, Theo M. C. M. de, Keun, Hector C., Athersuch, Toby J., Kelly, Rachel S., Lenner, Per, Hallmans, Göran, Stephanou, Euripides G., Myridakis, Antonis, Kogevinas, Manolis, Fazzo, Lucia, Santis, Marco De, Comba, Pietro, Bendinelli, Benedetta, Kiviranta, Hannu, Rantakokko, Panu, Airaksinen, Riikka, Ruokojarvi, Paivi, Gilthorpe, Mark, Fleming, Sarah, Fleming, Thomas, Tu, Yu-Kang, Lundh, Thomas, Chien, Kuo-Liong, Chen, Wei J., Lee, Wen-Chung, Kate Hsiao, Chuhsing, Kuo, Po-Hsiu, Hung, Hung, and Liao, Shu-Fen

Subjects
Limfomes, Citoquines, Cytokines, Lymphomas
Abstract

Recent prospective studies have shown that dysregulation of the immune system may precede the development of B‐cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, which were considered separately. Using a nested case–control study within two European prospective cohorts, we measured plasma levels of 28 immune markers in samples collected a median of 6 years before diagnosis (range 2.01–15.97) in 268 incident cases of BCL (including multiple myeloma [MM]) and matched controls. Linear mixed models and partial least square analyses were used to analyze the association between levels of immune marker and the incidence of BCL and its main histological subtypes and to investigate potential biomarkers predictive of the time to diagnosis. Linear mixed model analyses identified associations linking lower levels of fibroblast growth factor‐2 (FGF‐2 p = 7.2 × 10−4) and transforming growth factor alpha (TGF‐α, p = 6.5 × 10−5) and BCL incidence. Analyses stratified by histological subtypes identified inverse associations for MM subtype including FGF‐2 (p = 7.8 × 10−7), TGF‐α (p = 4.08 × 10−5), fractalkine (p = 1.12 × 10−3), monocyte chemotactic protein‐3 (p = 1.36 × 10−4), macrophage inflammatory protein 1‐alpha (p = 4.6 × 10−4) and vascular endothelial growth factor (p = 4.23 × 10−5). Our results also provided marginal support for already reported associations between chemokines and diffuse large BCL (DLBCL) and cytokines and chronic lymphocytic leukemia (CLL). Case‐only analyses showed that Granulocyte‐macrophage colony stimulating factor levels were consistently higher closer to diagnosis, which provides further evidence of its role in tumor progression. In conclusion, our study suggests a role of growth‐factors in the incidence of MM and of chemokine and cytokine regulation in DLBCL and CLL.

42. Longitudinal trends of per- and polyfluoroalkyl substances in children’s serum

Author

Koponen, Jani, Winkens, Kerstin, Airaksinen, Riikka, Berger, Urs, Vestergren, Robin, Cousins, Ian T., Karvonen, Anne M., Pekkanen, Juha, Kiviranta, Hannu, Koponen, Jani, Winkens, Kerstin, Airaksinen, Riikka, Berger, Urs, Vestergren, Robin, Cousins, Ian T., Karvonen, Anne M., Pekkanen, Juha, and Kiviranta, Hannu

43. Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses.

Author

Vermeulen R, Saberi Hosnijeh F, Bodinier B, Portengen L, Liquet B, Garrido-Manriquez J, Lokhorst H, Bergdahl IA, Kyrtopoulos SA, Johansson AS, Georgiadis P, Melin B, Palli D, Krogh V, Panico S, Sacerdote C, Tumino R, Vineis P, Castagné R, Chadeau-Hyam M, Botsivali M, Chatziioannou A, Valavanis I, Kleinjans JCS, de Kok TMCM, Keun HC, Athersuch TJ, Kelly R, Lenner P, Hallmans G, Stephanou EG, Myridakis A, Kogevinas M, Fazzo L, De Santis M, Comba P, Bendinelli B, Kiviranta H, Rantakokko P, Airaksinen R, Ruokojarvi P, Gilthorpe M, Fleming S, Fleming T, Tu YK, Lundh T, Chien KL, Chen WJ, Lee WC, Kate Hsiao C, Kuo PH, Hung H, and Liao SF

Subjects
Adult, Aged, Case-Control Studies, Chemokine CCL7 blood, Chemokine CX3CL1 blood, Europe, Female, Fibroblast Growth Factor 2 blood, Follow-Up Studies, Humans, Incidence, Lymphoma, Large B-Cell, Diffuse diagnosis, Lymphoma, Large B-Cell, Diffuse epidemiology, Lymphoma, Large B-Cell, Diffuse immunology, Male, Middle Aged, Multiple Myeloma diagnosis, Multiple Myeloma epidemiology, Multiple Myeloma immunology, Multivariate Analysis, Prognosis, Prospective Studies, Transforming Growth Factor alpha blood, Vascular Endothelial Growth Factor A blood, Biomarkers blood, Lymphoma, Large B-Cell, Diffuse blood, Multiple Myeloma blood
Abstract

Recent prospective studies have shown that dysregulation of the immune system may precede the development of B-cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, which were considered separately. Using a nested case-control study within two European prospective cohorts, we measured plasma levels of 28 immune markers in samples collected a median of 6 years before diagnosis (range 2.01-15.97) in 268 incident cases of BCL (including multiple myeloma [MM]) and matched controls. Linear mixed models and partial least square analyses were used to analyze the association between levels of immune marker and the incidence of BCL and its main histological subtypes and to investigate potential biomarkers predictive of the time to diagnosis. Linear mixed model analyses identified associations linking lower levels of fibroblast growth factor-2 (FGF-2 p = 7.2 × 10 -4 ) and transforming growth factor alpha (TGF-α, p = 6.5 × 10 -5 ) and BCL incidence. Analyses stratified by histological subtypes identified inverse associations for MM subtype including FGF-2 (p = 7.8 × 10 -7 ), TGF-α (p = 4.08 × 10 -5 ), fractalkine (p = 1.12 × 10 -3 ), monocyte chemotactic protein-3 (p = 1.36 × 10 -4 ), macrophage inflammatory protein 1-alpha (p = 4.6 × 10 -4 ) and vascular endothelial growth factor (p = 4.23 × 10 -5 ). Our results also provided marginal support for already reported associations between chemokines and diffuse large BCL (DLBCL) and cytokines and chronic lymphocytic leukemia (CLL). Case-only analyses showed that Granulocyte-macrophage colony stimulating factor levels were consistently higher closer to diagnosis, which provides further evidence of its role in tumor progression. In conclusion, our study suggests a role of growth-factors in the incidence of MM and of chemokine and cytokine regulation in DLBCL and CLL., (© 2018 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)

Published
2018
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