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This study aimed to investigate the risk factors and prognostic value of anxiety and depression in glioma patients. A total of 190 glioma patients who underwent resection were consecutively enrolled. Anxiety was assessed using hospital anxiety and depression scale (HADS) and Zung self-rating anxiety scale (SAS); depression was assessed with the use of HADS and Zung self-rating depression scale (SDS). All patients were followed up to death or 36 months. Overall survival (OS) was calculated according to the survival data. The prevalence of anxiety ranged from 36.3 to 37.4%, and the prevalence of depression ranged from 28.4 to 32.6% based on different assessment scales. Female, diabetes, and increased WHO grade were correlated with HADS anxiety and SAS anxiety, while female, single/divorced/widowed status, hyperlipidemia, diabetes, and CKD were associated with HADS depression and SDS depression. Further multivariate logistic analyses disclosed the following: single/divorced/widowed status and WHO grade were independent risk factors for HADS anxiety; female and hyperlipidemia were independent risk factors for SAS anxiety; whereas education duration (< 12 years), single/divorced/widowed status, and CKD were independent risk factors for HADS depression; female, single/divorced/widowed status, and hyperlipidemia were independent risk factors for SDS depression. Besides, HADS anxiety, SAS anxiety and SDS depression were correlated with shorter OS, while HADS depression was not. Our findings about the risk factors and prognostic value of anxiety and depression might aid for their early prevention and prognosis improvement in glioma patients.

N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous tetrapeptide with potential antifibrotic effect. However, the underlying mechanism in the anti-fibrosis is still unclear. Here, we try to investigate its biofunction and deeplying mechanism in liver fibrosis. Rats were administrated with carbon tetrachloride (CCl4) for liver fibrosis model. The roles of AcSDKP on hepatic stellate cells (HSCs) were detected in vitro using isolated cells treated by TGF-β1. The m

A novel star-[polystyrene-b-poly(ferrocenyloxy ethyl acryl ate)]6 with hexa- functional cyclotriphosphazene core (star-(PS-b-PFcEA)6) was synthesized by atom -transfer radical polymerization(ATRP) and its electrochemical behaviors and anion recognition was investigated through CV. The results indicated that increasing of molecular weight resulted in obvious decreasing of reduction peak potential Epc, and the oxidation peak potential Epa kept comparatively stable. Moreover, when titrating anion into polymer solution, Epc increased while Epa reduced evidently, which suggested that star-(PS-b-PFcEA)6 provided with high anion recognition capacity of .

Molar heat capacities of 4-(aminomethyl)benzoic acid were precisely measured with a small sample precision automated adiabatic calorimeter over the temperature range from 80 to 400 K, and the heat capacity data were fitted to a polynomial equation: C(p,m) = 162.01+91.771X+6.4372X(2)+1.7517X(3)-4.991X(4)+8.909X(5)+1.585X(6), X = (T235)/155. The constant-volume energy of combustion of the compound was measured by means of a precision oxygen bomb combustion calorimeter. The standard enthalpy values of combustion and formation were determined to be: Delta(c)H(m)(circle minus) = -(4300 +/- 4) kJ.mol(-1) and Delta(f)H(m)(circle minus) = -(420 +/- 5) kJ.mol(-1).