Search

Your search keyword '"Aina, Valentina"' showing total 100 results
Start Over Author "Aina, Valentina"
100 results on '"Aina, Valentina"'

25. The role of coordination chemistry in the development of innovative Gallium-based bioceramics: the case of Curcumin

Author

Menabue Ledi, Morterra Claudio, Pignedoli Francesca, Saladini Monica, Ferrari Erika, Malavasi Gianluca, Fantini Francesca, Aina Valentina, and Lusvardi Gigliola

Subjects
chemistry.chemical_classification, Active ingredient, Materials science, Metal ions in aqueous solution, Gallium-based bioactive glasses, General Chemistry, gel glasses, curcumin, bioactivity, drug delivery, Free radical scavenger, Coordination complex, chemistry.chemical_compound, chemistry, Drug delivery, Materials Chemistry, Curcumin, Organic chemistry, Chelation, Lewis acids and bases, dryg delivery, biomaterials
Abstract

Curcumin, an active ingredient in the traditional Ayurvedic herbal remedy [Curcuma longa L.], is nowadays also employed in western medicine for its pleiotropic activities, ranging from anticancer to its free radical scavenger ability. These features are related to curcumin's function as a metal chelator, especially being selective for hard Lewis acids, such as Ga3+ which has interesting pharmacological activities. We report the synthesis and characterization of bioactive gel and mesoporous Ga-containing phospho-silicate glasses loaded with curcumin, in which, for the first time, the design of novel drug delivery systems takes advantage of coordination chemistry. In particular, it was found that: (i) there is a direct correlation between the external surface area and the amount of loaded curcumin; (ii) the presence of Ga3+ species on the surface increases the quantity of drug molecules uploaded and slows down their release in the biological medium (SBF), hinting a coordination-like interaction between curcumin and the surface metal ions; (iii) curcumin molecules released in the SBF solution stabilize Ga3+ ions, avoiding their precipitation.

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results