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Objective The aim of the study was to evaluate the Cobas 4800 Assay and the SeqHPV Assay with self (S) and direct (D) cervical samples in the Chinese Multicenter Screening Trial (CHIMUST). Materials and methods The CHIMUST is a large population-based multicenter clinical trial, and 10,885 women aged 30-59 years from 15 sites in 7 provinces with no cervical cancer screening for 3 years were eligible. All participating women contributed one self-collected sample (S) and 1 physician-collected endocervical sample (DL). The self-collected sample was first applied to the solid media transport card (SS), and then, the brush placed in 6 mL of ThinPrepSolution (SL). All samples were tested with Cobas 4800 and SeqHPV high-risk HPV assays. Patients human papillomavirus positive (self or direct) were recalled for colposcopy and biopsies. Results A total of 10,399 women had complete data. The mean age was 43.9 years. A total of 1.4% (142/10,399) had cervical intraepithelial neoplasia (CIN) 2+ and 0.5% (54/10,339) had CIN 3+. In the liquid specimens, the overall HPV infection rates were 10.8% for Cobas and 10.9% for SeqHPV in D sample, and 13.7% for Cobas and 11.6% for SeqHPV in SL sample, respectively. The sensitivity of Cobas-DL, Cobas-SL, SeqHPV-DL, and SeqHPV-SL for CIN 2+ was 95.07%, 95.07%, 94.33%, and 96.48%, respectively. The specificity of Cobas-DL, Cobas-SL, SeqHPV-DL, and SeqHPV-SL for CIN 2+ was 90.38%, 87.35%, 90.21%, and 89.53%, respectively. There were no differences in sensitivity when applying the 2 assays to both self- and directly collected samples in liquid transport media (p > .05). Conclusions Both Cobas and SeqHPV screening assays using both self-collected and directly endocervical collected specimens demonstrate similar sensitivity for the detection of CIN 2+ and CIN 3+.

PurposeBody type classification has a great influence on plate making and garment sizing system, and the accuracy of body type classification method will greatly affect the fit of garment production. The purpose of this paper is to use the decision tree algorithm to study body classification rules, develop a decision tree body recognition model and judge the body shape of middle-aged women in Xinjiang.Design/methodology/approachFirst, perform dimensionless processing on the collected data of 256 middle-aged women in Xinjiang, and the dimensionless data were used for K-means body clustering; Then, quantitatively analyze the effectiveness of different classification clusters based on the silhouette coefficients. Second, the decision tree algorithm is used to divide the classified sample data into a training set and a test set at a ratio of 70/30, and select the best node and the best branch based on the Gini coefficient to construct a classification tree. Last, the overall optimal decision tree is generated by means of hyperparameter pruning.FindingsThe body shape of middle-aged women in Xinjiang can be divided into three types: standard body, plump body and obese body. The decision tree model has an excellent effect on body classification of middle-aged women in Xinjiang (precision (macro), 95.46%; precision (micro), 95.95%; recall (macro), 95.46%; recall (micro), 95.95%; F1 (macro), 95.46%; F1 (micro), 95.95%).Originality/valueFor scientific research, this paper is conducive to increasing the regional body type theory and stimulating the establishment of a garment sizing subdivision system in Xinjiang. In terms of production practice, this paper not only establishes a model for judging the shape of middle-aged women in Xinjiang, but also provides reference data for intermediates of various sizes. In addition, to facilitate pattern-making and the establishment of a subdivision system for the size of middle-aged women's garments in Xinjiang, this paper provides the grading values of various body control parts of middle-aged women in Xinjiang.

Background: This study aimed to evaluate three different patterns of cervical cancer screening strategies for detection of cervical diseases. Methods: In total, 10,186 women aged 21–70 years attending cervical screening program were recruited and cotested by human papillomavirus (HPV) assays and cytology. Three-year histological follow-up data was recorded on women with abnormal screening results, and six clinically common screening algorithms were evaluated. Results: Significantly better protection against cervical intraepithelial neoplasia 2 or worse (CIN2+) at three-year follow-up was associated with a negative HPV result than by normal cytology at baseline. HPV screening was more sensitive and less specific than cytology screening. Moreover, HPV screening with HPV16/18 and reflex cytology (atypical squamous cells of undetermined significance [ASCUS] threshold) showed a similar sensitivity (94.6% vs. 98.2%, p = 0.125) and a superior specificity as compared to cotesting reflex HPV16/18 and cytology (ASCUS threshold) for CIN2+ (95.8% vs. 95.1%, p < 0.0001), achieving a colposcopy referral rate of 5.4%, and consuming 4.8 colposcopies and 4.4 cytology tests to find one CIN2+. Conclusions: HPV screening with triage of HPV-positive women by HPV16/18 genotyping and cytology provided a good equilibrium between screening effectiveness, the number of cytology tests required, and referral rates; HPV testing was similar in sensitivity to cotesting and safer than cytology, thus especially suitable for large population-based screening programs.

Aim To compare thermocoagulation and cryotherapy for treatment of high‐grade cervical intraepithelial neoplasia (CIN). Methods From May 2017 to May 2018, women with CIN2/3 were randomized to thermocoagulation or cryotherapy at Peking University Shenzhen Hospital. Follow‐up at 4 and 8 months included cytology and human papillomavirus (HPV) testing. Women who were HPV‐positive or had atypical squamous cells of undetermined significance or higher‐grade disease underwent colposcopy/biopsy. Results Among 149 women enrolled, 74 were randomized to thermocoagulation, and 75 to cryotherapy (excluded four were immediately referred for thermocoagulation due to large lesions). At follow‐up, there was no difference between the thermocoagulation and cryotherapy groups in HPV‐negative (4/8 months: 72.5%/86.2% vs 68.6%/80.6%) and pathology‐negative (97.1%/98.5% vs 94.3%/92.3%) rates (all P > 0.05). The cytology‐negative rate was similar for thermocoagulation and cryotherapy at 4 months (79.7% vs 78.9%, P > 0.05), but higher for thermocoagulation at 8 months (100% vs 88.7%, P

Purpose When used for cervical cancer primary screening, liquid-based cytology (LBC) has a high specificity but a low sensitivity. For histological diagnosis of high-grade lesions, p16INK4a immunostaining has proven to be useful. Therefore, our objective was to evaluate the use of p16INK4a immuno-cytology as a primary screen and a secondary screen after primary high-risk human papillomavirus (hrHPV) screening or LBC screening. Methods A total of 1197 cytology slides were immuno-stained using automatic p16INK4a staining system (PathCIN®p16INK4a) in two studies from cervical screening programs. In the primary screening study, 875 slides were randomly selected and analyzed for p16INK4a. In the secondary screening study, 322 of the remaining slides were chosen by virtue of being HPV 16/18+, other hrHPV+/LBC≥ASC-US, or HPV-negative/LBC ≥LSIL. The sensitivity and specificity for detection of cervical intraepithelial neoplasia 2/3 or worse (CIN2+/CIN3+) were compared based on p16INK4a, LBC and HPV test results. Results In combining two studies, there were 431 cases with biopsy pathology. They included 83 cases with CIN2+ and 41 cases with CIN3+. The p16 positivity rate increased with pathologic and cytologic severity (P

Objectives: This study aimed to describe the study design, and to analyze the type-specific distribution of cervical high-risk human papillomavirus (hrHPV) infection and its association with cytological and histological results in a large population-based screening program in Buji Street, Shenzhen, China. Methods: A total of 10,186 women aged 21-70 years were co-tested by Cobas4800 HPV assay and liquid-based cytology. Women were referred to colposcopy by virtue of being HPV16/18-positive, Other hrHPV-positive/ cytology ≥ASCUS, or HPV-negative/ cytology ≥LSIL. Three-year histological follow-up data were recorded. Results: The overall prevalence of hrHPV infection was 11.1%; among them, the highest type was Other hrHPV (8.9%), followed by HPV16 (1.6%) and HPV18 (0.6%). Moreover, the prevalence of hrHPV and that of HPV16 increased with cytological severity (Ptrend

Purpose When used for cervical cancer primary screening, liquid-based cytology (LBC) has a high specificity but a low sensitivity. For histological diagnosis of high-grade lesions, p16INK4a immunostaining has proven to be useful. Therefore, our objective was to evaluate the use of p16INK4a immuno-cytology as a primary screen and a secondary screen after primary high-risk human papillomavirus (hrHPV) screening or LBC screening. Methods A total of 1197 cytology slides were immuno-stained using automatic p16INK4a staining system (PathCIN®p16INK4a) in two studies from cervical screening programs. In the primary screening study, 875 slides were randomly selected and analyzed for p16INK4a. In the secondary screening study, 322 of the remaining slides were chosen by virtue of being HPV 16/18+, other hrHPV+/LBC≥ASC-US, or HPV-negative/LBC ≥LSIL. The sensitivity and specificity for detection of cervical intraepithelial neoplasia 2/3 or worse (CIN2+/CIN3+) were compared based on p16INK4a, LBC and HPV test results. Results In combining two studies, there were 431 cases with biopsy pathology. They included 83 cases with CIN2+ and 41 cases with CIN3+. The p16 positivity rate increased with pathologic and cytologic severity (P

Additional file 1: Table supplement 1. Rate of HPV testing failure.

Development of superconducting undulators continues at the Advanced Photon Source (APS). Two years after successful installation and commissioning of the first relatively short superconducting undulator ``SCU0'' in Sector 6 of the APS storage ring, the second 1.1-m-long superconducting undulator ``SCU1'' was installed in Sector 1 of the APS. The device has been in user operation since its commissioning in May 2015. This paper describes the magnetic and cryogenic design of the SCU1 together with the results of stand-alone cold tests. The SCU1's magnetic and cryogenic performance as well as its operating experience in the APS storage ring are also presented.

Third-generation low-emittance storage-ring light sources based on double- and triple-bend cells and undulator magnets have been in operation around the world for more than two decades. On the horizon is a new generation based on the multi-bend achromat (MBA) lattice concept promising two to three orders of magnitude higher brightness than is available in today's sources. In this paper, the challenges inherent in designing MBA lattices, as well as potential solutions, are described. Topics covered include lattice concepts, scaling of storage-ring performance, brightness optimization, nonlinear dynamics, beam lifetime and injection schemes.

Textile patterns in each minority which contain cultural, historical, artistical, and reginal features are precious because of its unique aesthetic characteristics. More than 78 typical classical patterns of Kirgiz Yormac which is a kind of Kirgiz home-made textile are collected through field investigation, and digitalized by CorelDraw based on the concept of pattern primitives. Three methods for obtaining the pattern primitive units are proposed, and a pattern primitive library is established. It is found that the most popular Yormac pattern items are the ram horn, the flying eagles, and geometric figures, with a symmetrical configuration and structure. Red is the most epidemic color with the proportion over 70% of the pattern collected. By statistically and literature analysis, it can be concluded that Kirgiz textile pattern comes from life, being used in life. The custom, implication, spirit of Kirgiz shown in pattern come down in one continuous line with national pattern, and are highly in conformity with the culture and tradition of Chinese nation. The feature analysis of Yormac pattern, and construction of pattern primitive library is done for better comprehension of Kirgiz culture, and thus protecting and inheriting the Kirgiz intangible culture heritage.

A decade-long effort at the Advanced Photon Source (APS) of Argonne National Laboratory (ANL) on development of superconducting undulators culminated in December 2012 with the installation of the first superconducting undulator ``SCU0'' into Sector 6 of the APS storage ring. The device was commissioned in January 2013 and has been in user operation since. This paper presents the magnetic and cryogenic design of the SCU0 together with the results of stand-alone cold tests. The initial commissioning and characterization of SCU0 as well as its operating experience in the APS storage ring are described.

A direct space-charge force model has been implemented in the tracking code elegant [1]. The user can simulate transverse space-charge effects by inserting space- charge elements in the beamline at any desired position. Application to the international linear collider damping ring is presented in this paper. We simulated beam under equilibrium conditions, as well as the entire damping cycle from injection to extraction. Results show that beam halo is generated due to space-charge effects. This would be a significant concern for the ILC damping ring and a detailed follow-up study is needed.

The advanced photon source (APS) recently held a workshop on upgrade options for the APS storage ring. Several options were discussed that included both storage ring and energy recovery linac options. Here we present a storage ring lattice that fits into the APS tunnel and has a number of significant improvements over the existing storage ring. The present APS lattice has 40-fold symmetry with each sector having one 5-m-long straight section for insertion device (ID) placement. Each sector also provides one beamline for radiation from the bending magnet. The upgrade lattice preserves locations of the existing insertion devices but provides for increased ID straight section length to accommodate 8-m-long insertion devices. This lattice also decreases emittance by a factor of two down to 1.6 nm-rad. And last but not least, it provides two additional 2.1-m-long ID straight sections per sector with one of these straight sections being parallel to the existing bending magnet beamline. We also present dynamic aperture optimization, lifetime calculations, and other nonlinear-dynamics-related simulations.

We recently studied a lattice achieving 1 -nm emittance at the APS storage ring [1]. The successful design required very strong sextupoles in order to tune the machine to the desired positive chromaticity. A preliminary design of such magnets indicated saturation in the poles unless the vacuum chamber gets smaller by a factor of two compared to the existing APS chamber. Since the resistive wall impedance scales as 1/b3, where b is the radius of the chamber, we questioned how much current we can store in a single bunch at the 1-nm storage ring. In order to answer this question quantitatively, we calculated all wake potentials of impedance elements of the existing APS storage ring with the transverse dimension properly scaled but with the longitudinal dimension kept unchanged. With the newly calculated impedance of a smaller chamber, we estimated the single- bunch current limit. It turned out that the ring with a smaller chamber would not diminish the single-bunch current limit substantially. We present both wake potentials of 1-nm and the existing rings followed by the simulation results carried out for determining the accumulation limit to the ring.

We present a lattice design based on the theoretical- minimum-emittance (TME) cell for the international linear collider (ILC) 6.6-km 5-GeV damping ring. Several areas are discussed: momentum compaction, lattice layout, injection and extraction, circumference adjusters, phase adjuster, and dynamic aperture calculation with multipole errors.

We present a triple-bend lattice design that uses the current APS tunnel. The new lattice has a 1 nm-rad effective emittance at 7 GeV. A forty-period symmetric optics is presented. For the benefit of some X-ray user experiments, an optics with four special straight sections of one-third the beam size of normal sections was investigated as well. The associated nonlinear optical difficulties are addressed and simulation results are presented.