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44 results on '"Aikawa, Takashi"'

9. Perivascular fibrosis of muscular pulmonary arteries in chronic obstructive pulmonary disease

Author

Andoh, Yukiko, Shimura, Sanae, Aikawa, Takashi, Sasaki, Hidetada, and Takishima, Tamotsu

Subjects
Pulmonary fibrosis -- Case studies -- Development and progression -- Complications and side effects, Lung diseases, Obstructive -- Development and progression -- Case studies -- Complications and side effects, Cardiovascular diseases -- Case studies -- Development and progression -- Complications and side effects, Health, Complications and side effects, Development and progression, Case studies
Abstract

We performed a morphometric analysis of peribronchiolar and perivascular fibrosis in lungs obtained at autopsy from six patients with chronic bronchitis, six with pulmonary emphysema, and four normal control subjects. The areas of fibrosis outside the smooth muscle layer of bronchioles and outside the external elastic lamina of muscular pulmonary arteries were measured and their thickness was then calculated by assuming a round airway or artery. Patients with chronic bronchitis had significantly thicker peribronchiolar fibrosis in bronchioles of 1 mm or less in diameter and also thicker perivascular fibrosis of the adjacent muscular pulmonary arteries than the other two groups. The extent of perivascular fibrosis was significantly correlated with peribronchiolar fibrosis only in the muscular pulmonary arteries adjacent to the bronchioles but not in those away from the bronchioles. These findings suggest direct extension of chronic inflammation from bronchioles to the adjacent muscular pulmonary arteries in chronic bronchitis but not in pulmonary emphysema. Such perivascular fibrosis might lead to sustained pulmonary hypertension. (Chest 1992; 102:1645-50) ATS = American Thoracic Society; CB = chronic bronchitis; NL = control group; PE = pulmonary emphysema; SAB = selective alveolobronchogram, Chronic obstructive pulmonary disease (COPD), particularly chronic obstructive bronchitis, is often accompanied by cor pulmonale as a consequence of pulmonary hypertension.[1-4] It has been suggested that pulmonary hypertension in COPD [...]

Published
1992

12. Pre- and postjunctional muscarinic receptor subtypes in dog airways

Author

Sasaki Hidetada, Ohrui Takashi, Sekizawa Kiyohisa, Takishima Tamotsu, Aikawa Takashi, and Itabashi Sigeru

Subjects
Atropine, medicine.medical_specialty, Bronchiole, Bronchi, In Vitro Techniques, chemistry.chemical_compound, Dogs, Piperidines, Internal medicine, Muscarinic acetylcholine receptor, medicine, Animals, Methiodide, Pharmacology, Bronchus, Dose-Response Relationship, Drug, Antagonist, Parasympatholytics, Muscle, Smooth, Pirenzepine, respiratory system, Receptors, Muscarinic, Acetylcholine, Electric Stimulation, medicine.anatomical_structure, Endocrinology, chemistry, medicine.drug, Muscle Contraction
Abstract

To examine muscarinic receptor subtypes involved in cholinergically mediated contractions of the airway, we studied the effects of the M 1 -selective antagonist, pirenzepine, the M 2 -selective antagonist, AF-DX 116, the M 3 -selective antagonist, 4-diphenyl-acetoxy-N-methylpiperidine (4-DAMP) methiodide, and the non-selective antagonist, atropine, on acetylcholine (ACh)- and electrically induced contractions in dog bronchi and bronchioles. The relative potencies of the antagonists based on IC 50 values of each antagonist for contractions induced by the two concentrations of ACh that produced 50% of the maximum (ed 50 ) and the maximum (ED max ) contractions and the pA 2 values were atropine ≥ 4-DAMP methiodide > pirenzepine = AF-DX 116 in both the bronchi and bronchioles. The IC 50 and pA 2 values of each antagonist did not differ significantly between the bronchi and bronchioles. 4-DAMP methiodide significantly inhibited the contractile response to electrical field stimulation (EFS) at 5 Hz at concentrations that did not alter the contractile responses to exogenous ACh in both the bronchi and bronchioles, whereas pirenzepine, AF-DX 116 and atropine inhibited the EFS-induced contraction only at the concentrations that reduced the contraction induced by exogenous ACh. The present results suggest that the cholinergic contraction is mediated via the postsynaptic receptor M 3 , based on functional potencies of muscarinic antagonists and presynaptic receptor auto-facilitatory M 3 , based on the suppression of the contractile response to EFS by 4-DAMP methiodide in central and peripheral airways.

Published
1991

27. Preparation of a fine powder of 2-deoxy-2-[F]fluoro-D-glucose suitable for inhalation to diagnose lung diseases by means of PET.

Author

Ojima, Fumiyoshi, Ido, Tatsuo, Takahashi, Toshihiro, Hatazawa, Jun, Ito, Masatoshi, Sasaki, Hidetada, Yanai, Masaru, Aikawa, Takashi, Takishima, Tamotsu, Abiko, Kenji, and Amano, Masafumi

Abstract

Fine 2-deoxy-2-[F]fluoro-D-glucose (FDG) powder was obtained by adding diethyl ether into a methyl alcohol solution ofFDG and other sugar as seed. When micronized particles of sodium N-acetyl-neuraminate (Neu5Ac-Na) were used as seed crystals, particles containingFDG were obtained and 80% of them were smaller than 10μm in size. More than 60 % of these crystals were 4-6 μm in size. In a preclinical study of forced inhalation in a dog, theFDG fine powder was mainly distributed in the trachea. The radioactivity in the trachea then increased once and a gradual decrease followed. The radioactivity was transferred into the blood and radioactivity incorporation into the heart was observed. After a normal volunteer inhaledFDG dry powder aerosol, the radioactivity was found in the respiratory tract and the peripheral area of the lung by means of PET. Absorption and in vivo dynamics of theFDG were also analysed. [ABSTRACT FROM AUTHOR]

Published
1989
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31. Enhanced Endothelial Cell Proliferation in Acute Kawasaki Disease MucoCutaneous Lymph Node Syndrome

Author

HASHIMOTO, YOSHIMI, YOSHINOYA, SADAYOSHI, AIKAWA, TAKASHI, MITAMURA, TADAYUKI, MIYOSHI, YUJI, MURANAKA, MASAHARU, MIYAMOTO, TERUMASA, YANASE, YOSHIO, and KAWASAKI, TOMISAKU

Abstract

Paired sera from 30 patients with mucocutaneous lymph node syndrome (Kawasaki disease) were studied for possible effects on human vascular endothelial cells growth in vitro.The majority of sera from acute phase muco-cutaneous lymph node syndrome patients significantly enhanced endothelial cell proliferation more than those from convalescent phase patients, infectious diseases patients, and age-matched normal controls. This stimulation was considered to be specific for EC since muco-cutaneous lymph node syndrome sera did not enhance fibroblast growth more than normal sera. Fractionation of the serum with gel filtration failed to clearly detect the molecular properties of this effect, although both heavy and light material possessed this activity. Extensive search for circulating immune complex in muco-cutaneous lymph node syndrome sera were negative, suggesting that the enhanced endothelial cell proliferation was due to serum components other than immune complexes.

Published
1986

32. Enhanced Endothelial Cell Proliferation in Acute Kawasaki Disease (Muco-Cutaneous Lymph Node Syndrome)

Author

Hashimoto, Yoshimi, Yoshinoya, Sadayoshi, Aikawa, Takashi, Mitamura, Tadayuki, Miyoshi, Yuji, Muranaka, Masaharu, Miyamoto, Terumasa, Yanase, Yoshio, and Kawasaki, Tomisaku

Abstract

Abstract: Paired sera from 30 patients with mucocutaneous lymph node syndrome (Kawasaki disease) were studied for possible effects on human vascular endothelial cells growth in vitro. The majority of sera from acute phase muco-cutaneous lymph node syndrome patients significantly enhanced endothelial cell proliferation more than those from convalescent phase patients, infectious diseases patients, and age-matched normal controls. This stimulation was considered to be specific for EC since muco-cutaneous lymph node syndrome sera did not enhance fibroblast growth more than normal sera. Fractionation of the serum with gel filtration failed to clearly detect the molecular properties of this effect, although both heavy and light material possessed this activity. Extensive search for circulating immune complex in muco-cutaneous lymph node syndrome sera were negative, suggesting that the enhanced endothelial cell proliferation was due to serum components other than immune complexes.

Published
1986
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