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45 results on '"Aikawa, Hirokazu"'

32. What kind of hilar lung cancer can be a candidate for segmentectomy with curative intent?: Retrospective clinicopathological study of completely resected roentgenographically occult bronchogenic squamous cell carcinoma

Author

Endo, Chiaki, primary, Sagawa, Motoyasu, additional, Sato, Masami, additional, Sakurada, Akira, additional, Aikawa, Hirokazu, additional, Takahashi, Satomi, additional, Usuda, Katsuo, additional, Saito, Yasuki, additional, and Fujimura, Shigefumi, additional

Published
1998
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37. Multicentricity in resected occult bronchogenic squamous cell carcinoma

Author

Saito, Yasuki, primary, Sato, Masami, additional, Sagawa, Motoyasu, additional, Kanma, Keiji, additional, Takahashi, Satomi, additional, Usuda, Katsuo, additional, Nagamoto, Noriyoshi, additional, Endo, Chiaki, additional, Chen, Yan, additional, Sakurada, Akira, additional, Aikawa, Hirokazu, additional, and Fujimura, Shigefumi, additional

Published
1994
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39. Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission tomography in lung cancer.

Author

Usuda, Katsuo, Sagawa, Motoyasu, Aikawa, Hirokazu, Ueno, Masakatsu, Tanaka, Makoto, Machida, Yuichiro, Zhao, Xi-Tong, Ueda, Yoshimichi, Higashi, Koutaro, and Sakuma, Tsutomu

Abstract

The aim of this study was to determine if glucose transporter-1 (Glut1) expression correlates with 18F-FDG (18F-fluoro-2-deoxyglucose) uptake on positron emission tomography (PET) in lung cancer and to examine the similarities and differences between them. A total of 34 patients with resected primary lung cancers were investigated in this study. There were 17 adenocarcinomas, 12 squamous cell carcinomas, and 5 cancers of other cell types. Immunohistochemical Glut1 intensity was categorized into three groups: negative, positive, and strongly positive. Glut1 frequency was defined by the proportion of positive cells among all cancer cells, and it was graded on a semiquantitative scale as 0–100% in 10% increments. The data are expressed as the mean ± SD. Maximum standardized uptake values (SUVmax) were 4.8 ± 6.3 in “negative” Glut1 intensity cases, 4.7 ± 3.1 in “positive” Glut1 intensity cases, and 11.2 ± 5.2 in “strongly positive” Glut1 intensity cases. Although SUVmax correlated significantly with tumor size (correlation coefficient 0.58, P = 0.00033), Glut1 frequency did not correlate significantly with tumor size (correlation coefficient 0.18, P = 0.301). Cell type and cell differentiation correlated significantly with Glut1 expression and 18F-FDG uptake. Glut1 expression correlates significantly with 18F-FDG uptake. There are similarities in cell differentiation and cell type between Glut1 expression and 18F-FDG uptake. 18F-FDG uptake correlates significantly with tumor size, but Glut1 expression does not. [ABSTRACT FROM AUTHOR]

Published
2010
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40. Increased Reabsorption of Alveolar Edema Fluid in the Obese Zucker Rat.

Author

Gang Ma, Xitong Zhao, Ueno, Masakatsu, Tanaka, Makoto, Machida, Yuichiro, Aikawa, Hirokazu, Usuda, Katsuo, Sagawa, Motoyasu, Ueda, Yoshimichi, and Sakuma, Tsutomu

Abstract

Diabetic patients have a decreased incidence of acute respiratory distress syndrome, but the mechanism responsible for the decreased incidence is uncertain. Reabsorption of alveolar edema fluid (alveolar fluid clearance) has been considered to play an important role in resolution of acute respiratory distress syndrome. However, little is known regarding alveolar fluid clearance in diabetes mellitus. Since the obese Zucker rat has been used as an experimental model for diabetes mellitus, we determined if alveolar fluid clearance increased in the obese Zucker rat. First, we compared alveolar fluid clearance in obese Zucker rats with that in lean Zucker rats and Sprague-Dawley (SD) rats. Then, we determined the role of sodium channel, Na,K-ATPase, and β2-adrenoceptor, which drives alveolar fluid clearance, in obese Zucker rats. Alveolar fluid clearance was estimated by the progressive increase in alveolar albumin concentrations in the isolated lungs. We found that basal alveolar fluid clearance in obese Zucker rats was two-fold greater than that in lean Zucker rats and SD rats. The mRNA expression of α1-, β1-Na, K-ATPase and β2-adrenoceptor, but not mRNA expression of sodium channel, increased in obese Zucker rats. A selective β2-agrenergic antagonist, but not a Na, K-ATPase inhibitor, specifically inhibited the increase in alveolar fluid clearance in obese Zucker rats. These results indicate that overexpression of β2-adrenoceptor primarily increases basal alveolar fluid clearance in the obese Zucker rat. We speculate that the stimulation of alveolar fluid clearance ameliorates acute respiratory distress syndrome in patients with diabetes mellitus. [ABSTRACT FROM AUTHOR]

Published
2008
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42. Behavior of Some Impurities in the Electro-refining of Iron

Author

Oka, Shumpei, Mukaibo, Takashi, and Aikawa, Hirokazu

Abstract

Phosphate ions were found to deposit themselves on the cathode like a cation. This phenomenon suggests the formation of a complex ion which has positive charges. The results on sulfur confirms the importance of washing which was pointed out by Schafer and Harr in achieving low values of total sulfur in the deposited metal. Silver was eliminated effectively by electrolysis, but it will be still difficult to remove zinc from iron by electrolysis.

Published
1960
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43. [Screening for lung cancer: present and future].

Author

Sagawa M, Usuda K, Aikawa H, Tanaka M, Machida Y, Ueno M, and Sakuma T

Subjects
Humans, Smoking, Tomography, X-Ray Computed, Early Detection of Cancer, Lung Neoplasms diagnosis
Abstract

A certified method for lung cancer screening in Japan is the combination of chest X-ray and sputum cytology. The chest Xray examination is intended primarily for the detection of peripheral-type lung cancer. Interpretation of the films should be performed by two different physicians, and the films of screenees suspected to have abnormal shadow should be compared to the same screenee's films from previous screening visits. Sputum cytology is conducted for heavy smokers, and is useful for early detection of central lung cancer. The efficacy of this lung cancer screening method has been shown in several case control studies. There are some problems to solve i. e., a low rate of attendance and inadequate quality control. Low-dose thoracic CT screening is performed with an exposure within a single breath hold, and its interpretation can be conducted with films, CRT, or a LCD monitor. Even when taken at low doses, the radiation exposure dose is large compared to a chest X-ray, being about 3-10 times greater than the absorbed dose and 20-40 times greater than the effective dose. Since the radiation dose in a usual clinical condition is much higher, the clinical condition is not recommended for screening. Concerning the efficacy of low-dose CT screening for heavy-smokers, a positive result was reported in June 2011, and further detailed analyses are required. There are still some problems to solve i. e., the management of undiagnosed shadows, harm caused by the screening, quality control, and efficacy in non-smokers.

Published
2012

44. [Multidisciplinary treatment of lung cancer in 21st century].

Author

Aikawa H, Sagawa M, Usuda K, Ueno M, Tanaka M, Machida Y, and Sakuma T

Subjects
Combined Modality Therapy, Humans, Japan, Lung Neoplasms therapy
Abstract

Lung cancer is the leading cause of cancer deaths in Japan. Recently, big progress in the treatment of lung cancer has been achieved, such as new anti-cancer drugs, molecular targeted therapy, stereotactic radiotherapy, etc. Multidisciplinary approach has been required to the therapy for lung cancer patients. In this paper, we introduce The 21st Century Multidisciplinary Center in Kanazawa Medical University, and the Hokuriku Training Program for Making Specialists in Cancer Treatment.

Published
2008

45. Beta-blocker prevented repeated pulmonary hypertension episodes after bilateral lung transplantation in a patient with primary pulmonary hypertension.

Author

Okada Y, Hoshikawa Y, Ejima Y, Matsumura Y, Sado T, Shimada K, Aikawa H, Sugawara T, Matsuda Y, Takahashi T, Sato M, and Kondo T

Subjects
Adult, Hemodynamics, Humans, Hypertension, Pulmonary physiopathology, Hypertension, Pulmonary surgery, Male, Secondary Prevention, Adrenergic beta-Antagonists therapeutic use, Hypertension, Pulmonary prevention & control, Lung Transplantation, Propranolol therapeutic use
Published
2004
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