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Your search keyword '"Aikaterini Giaouzaki"' showing total 3 results
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3 results on '"Aikaterini Giaouzaki"'

1. Long-term serial changes in platelet activation indices following sirolimus elution and bare metal stent implantation in patients with stable coronary artery disease

Author

Maria Marketou, George E. Kochiadakis, Aikaterini Giaouzaki, Katerini Sfiridaki, Stelios Petousis, Fragiskos Maragoudakis, Konstantinos Roufas, Despoina Vougia, John Logakis, Gregory Chlouverakis, and Panos E. Vardas

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Platelet activation is crucial in the development of stent thrombosis following percutaneous coronary intervention (PCI). We carried out a long-term assessment of multiple factors implicated in the thrombotic process and monitored markers of platelet activation after the implantation of sirolimus-eluting stents (SES) in patients with stable coronary artery disease (CAD). Additionally, we compared these findings with those after bare-metal stent (BMS) implantation. Methods: A cohort of 47 consecutive patients, aged 70% narrowing of the lumen) of one major epicardial coronary artery and stable CAD underwent successful elective PCI. Patients were randomly allocated to SES (n = 25) or BMS (n = 22). Venous blood was obtained 24 hours before and 24 hours, 48 hours, 1 month, and 6 months after PCI for measurements of plasma levels of sP-selectin, von Willebrand Factor (vWF), fibrinogen, d-dimer, sCD40, factor VIII, b-thromboglobulin (b-TG) and platelet factor 4 (PF-4). Results: There were no significant differences between the two groups in levels of fibrinogen or d-dimers in peripheral blood. However, we observed a significant kinetic effect (p

Published
2017
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2. TLR2 and TLR4 Gene Expression in Peripheral Monocytes in Nondiabetic Hypertensive Patients: The Effect of Intensive Blood Pressure-Lowering

Author

Panos E. Vardas, George E. Kochiadakis, Gregory Chlouverakis, Evangelos A. Zacharis, Joanna E. Kontaraki, Maria E. Marketou, and Aikaterini Giaouzaki

Subjects
medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Standard treatment, Case-control study, Essential hypertension, medicine.disease, Pathogenesis, TLR2, Endocrinology, Blood pressure, Internal medicine, Internal Medicine, medicine, Cardiology and Cardiovascular Medicine, Receptor, Prospective cohort study, business
Abstract

The activation of innate immune receptors, such as Toll-like receptors (TLRs), participates in the pathogenesis of cardiovascular diseases. The authors evaluated TLR2 and TLR4 gene expression in the peripheral monocytes of nondiabetic hypertensive patients compared with normotensive individuals and investigated the effect of intensive systolic blood pressure (SBP)-lowering. Included were 43 nondiabetic hypertensive patients with essential hypertension who were randomly assigned to an intensive treatment arm, with an SBP target of

Published
2012
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3. Oxidative stress changes after stent implantation: a randomized comparative study of sirolimus-eluting and bare metal stents

Author

Nikolaos E. Igoumenidis, Gregory Chlouverakis, George E. Kochiadakis, Emmanuel I. Skalidis, Dimitris A. Arfanakis, Panos E. Vardas, Aikaterini Giaouzaki, Dragana Nikitovic, and Maria E. Marketou

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Urology, medicine.disease_cause, Coronary artery disease, Coronary Restenosis, Restenosis, Angioplasty, medicine, Humans, Antibacterial agent, Aged, Sirolimus, business.industry, Coronary Stenosis, Drug-Eluting Stents, Middle Aged, medicine.disease, Surgery, Oxidative Stress, Treatment Outcome, Drug-eluting stent, Metals, Conventional PCI, Female, Stents, Cardiology and Cardiovascular Medicine, business, Oxidative stress, medicine.drug, Follow-Up Studies
Abstract

Background Although oxidative stress plays an important role in the pathophysiology of restenosis, its role following the implantation of sirolimus-eluting stents (SES) is unknown. Methods We examined the relation between total peroxides (TP), a marker of oxidative stress, and in-stent late luminal loss over a 6-month follow-up in patients with stable coronary artery disease and compared the results from SES with those from bare metal stents (BMS). We enrolled 75 consecutive patients, who underwent successful PCI and were randomly allocated to SES ( n =37) or BMS ( n =38). Blood samples were taken 24 h before, at 24 h, 48 h and 1 month after angioplasty; levels of TP were determined on each occasion. Follow-up coronary angiography was performed 6–8 months later. Results TP levels in the BMS group were significantly higher at 24 h and 48 h compared to baseline ( p =0.006 for both). At one month there was a significant decline from the 48 h levels ( p =0.029) to levels slightly, but not significantly higher than baseline. In contrast, in SES TP levels showed no significant changes during the first 48 h, while they declined to levels somewhat lower than baseline at 30 days. A significant correlation was found between TP changes and in-stent late luminal loss at 6 months in both groups. Conclusion Our study showed that patients with stable coronary artery disease who received SES have a different behavior of oxidative stress after stenting compared with BMS, and this could contribute to the difference in restenosis rate between these 2 types of stents.

Published
2008

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