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3 results on '"Ai Kawamura, MD, PhD"'

1. Impact of complete revascularization in coronary artery bypass grafting for ischemic cardiomyopathyCentral MessagePerspective

Author

Masaro Nakae, MD, Satoshi Kainuma, MD, PhD, Koichi Toda, MD, PhD, Yasushi Yoshikawa, MD, PhD, Hiroki Hata, MD, PhD, Daisuke Yoshioka, MD, PhD, Takuji Kawamura, MD, PhD, Ai Kawamura, MD, PhD, Noriyuki Kashiyama, MD, PhD, Takayoshi Ueno, MD, PhD, Toru Kuratani, MD, PhD, Haruhiko Kondoh, MD, PhD, Arudo Hiraoka, MD, PhD, Taichi Sakaguchi, MD, PhD, Hidenori Yoshitaka, MD, PhD, Yukitoshi Shirakawa, MD, PhD, Toshiki Takahashi, MD, PhD, Masayuki Sakaki, MD, PhD, Takafumi Masai, MD, PhD, Sho Komukai, PhD, Tetsuhisa Kitamura, MD, MS, DPH, Atsushi Hirayama, MD, MPH, Yoshimitsu Shimomura, MD, and Shigeru Miyagawa, MD, PhD

Subjects
ischemic cardiomyopathy, coronary artery bypass grafting, complete revascularization, long-term follow-up, left ventricular function, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811
Abstract

Objective: In patients with ischemic cardiomyopathy, coronary artery bypass grafting ensures better survival than medical therapy. However, the long-term clinical impact of complete revascularization remains unclear. This observational study aimed to evaluate the effects of complete revascularization on long-term survival and left ventricular functional recovery in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting. Methods: We retrospectively reviewed outcomes of 498 patients with ischemic cardiomyopathy who underwent complete (n = 386) or incomplete (n = 112) myocardial revascularization between 1993 and 2015. The baseline characteristics were adjusted using inverse probability of treatment weighting to reduce the impact of treatment bias and potential confounding. The mean follow-up duration was 77.2 ± 42.8 months in survivors. Results: The overall 5-year survival rate (complete revascularization, 72.5% vs incomplete revascularization, 57.9%, P = .03) and freedom from all-cause death and/or readmission due to heart failure (54.5% vs 40.1%, P = .007) were significantly greater in patients with complete revascularization than those with incomplete revascularization. After adjustments using inverse probability of treatment weighting, the complete revascularization group demonstrated a lower risk of all-cause death (hazard ratio, 0.61; 95% confidence interval, 0.43-0.86; P = .005) and composite adverse events (hazard ratio, 0.59; 95% confidence interval, 0.44-0.79; P

Published
2023
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2. Ventricular arrhythmias following coronary artery bypass grafting for ischemic cardiomyopathy: When to insert an implanted cardioverter defibrillator?Central MessagePerspective

Author

Masaro Nakae, MD, Satoshi Kainuma, MD, PhD, Koichi Toda, MD, PhD, Daisuke Yoshioka, MD, PhD, Takuji Kawamura, MD, PhD, Ai Kawamura, MD, PhD, Noriyuki Kashiyama, MD, PhD, Sho Komukai, PhD, Tetsuhisa Kitamura, MD, MS, DPH, Atsushi Hirayama, MD, MPH, Yoshimitsu Shimomura, MD, Kazuhiro Taniguchi, MD, PhD, and Shigeru Miyagawa, MD, PhD

Subjects
coronary artery bypass grafting, ischemic cardiomyopathy, sudden cardiac death, ventricular arrhythmia, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811
Abstract

Objectives: The study objectives were to determine the incidence, predictors, and clinical impact of ventricular arrhythmias after coronary artery bypass grafting and to evaluate the impact of implantable cardioverter defibrillators on the survival of patients with ventricular arrhythmias. Methods: We enrolled 498 patients with a left ventricular ejection fraction of 40% or less who underwent coronary artery bypass grafting between 1993 and 2015. Clinical follow-up was completed in 94.0% of patients, with a median follow-up of 58.4 months. Results: Overall, 212 patients (43%) died, mainly of heart failure (n = 54, 10.8%) or sudden cardiac death (n = 40, 8.0%). The sudden cardiac death rate was highest during the first 6 months, with a monthly rate of 0.37%. Overall, 99 patients (20%) developed postoperative ventricular arrhythmias, and implantable cardioverter defibrillator was implanted in 55 patients. Previous ventricular arrhythmias (hazard ratio, 3.22; 95% confidence interval, 1.98-5.24; P

Published
2023
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3. Multiple percutaneous coronary interventions worsen outcomes for subsequent surgical correction of chronic ischemic mitral regurgitationCentral MessagePerspective

Author

Satoshi Kainuma, MD, PhD, Koichi Toda, MD, PhD, Shigeru Miyagawa, MD, PhD, Daisuke Yoshioka, MD, PhD, Takuji Kawamura, MD, PhD, Ai Kawamura, MD, PhD, Noriyuki Kashiyama, MD, PhD, Toru Kuratani, MD, PhD, Kensuke Yokoi, MD, PhD, Seiko Ide, MD, PhD, Isamu Mizote, MD, PhD, Hidetaka Kioka, MD, PhD, Tomohito Ohtani, MD, PhD, Shungo Hikoso, MD, PhD, Haruhiko Kondoh, MD, PhD, Arudo Hiraoka, MD, PhD, Taichi Sakaguchi, MD, PhD, Hidenori Yoshitaka, MD, PhD, Tetsuhisa Kitamura, MD, DPH, MS, Sho Komukai, PhD, Atsushi Hirayama, MD, MPH, Kazuhiro Taniguchi, MD, PhD, Yasushi Sakata, MD, PhD, Yoshiki Sawa, MD, PhD, Yasushi Yoshikawa, Hiroki Hata, Toshihiro Funatsu, Takafumi Masai, Yukitoshi Shirakawa, Toshiki Takahashi, Hiroyuki Nishi, Masashi Kawamura, Osamu Monta, and Takashi Yamauchi

Subjects
ischemic mitral regurgitation, percutaneous coronary intervention, restrictive mitral annuloplasty, left ventricular reverse remodeling, coronary artery bypass grafting, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811
Abstract

Objective: We investigated whether or not a history of multiple percutaneous coronary interventions (PCIs) is associated with clinical outcomes after surgery for ischemic mitral regurgitation. Methods: A total of 309 patients with chronic ischemic mitral regurgitation and left ventricular ejection fraction ≤40% who underwent restrictive mitral annuloplasty were classified as follows: patients with no or 1 previous PCI (nonmultiple PCI group [n = 211]) and patients with 2 or more previous PCIs (multiple PCIs group [n = 98]). Mean follow-up duration was 53 ± 40 months. Results: Before surgery, there were no intergroup differences in patient demographic characteristics except for lower estimated glomerular filtration rate in patients with multiple PCIs. These patients underwent concomitant coronary artery bypass grafting less frequently with a lower number of distal anastomoses (P

Published
2021
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