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Objective To explore the prevalence of osteoporosis in adult women in Inner Mongolia Autonomous Region and to analyze the influencing factors. Methods Totally 1 333 adult women from 4 regions of Inner Mongolia were selected by stratified cluster random sampling method from July 2014 to December 2015. Questionnaire survey, physical examination and laboratory testing were conducted. Calcaneal bone mineral density was measured by dry ultrasound bone mineral density analyzer. Univariate and multivariate Logistic regression were used to analyze the influencing factors of osteoporosis in adult women. Results The prevalence of osteoporosis in adult women in Inner Mongolia was 7.88% (standardized rate 8.56%). Logistic regression analysis showed that the protective factors of osteoporosis prevalence included young age, high intensity of physical exercise and high height (P＜0.05), while menopause was an independent risk factor for osteoporosis (P＜0.05). Conclusions The osteoporosis of adult women in Inner Mongolia is closely related to age, physical exercise, menopause and body height.

Abstract Background Dihydropyrimidinase like 2 (DPYSL2) has been linked to tumor metastasis. However, the function of DPSY2L in lung adenocarcinoma (LUAD) is yet to be explored. Methods Herein, we assessed DPYSL2 expression in various tumor types via online databases such as Oncomine and Tumor Immune Estimation Resource (TIMER). Further, we verified the low protein and mRNA expressions of DPYSL2 in LUAD via the ULCAN, The TCGA and GEPIA databases. We applied the ROC curve to examine the role of DPYSL2 in diagnosis. The prognostic significance of DPYSL2 was established through the Kaplan–Meier plotter and the Cox analyses (univariate and multivariate). TIMER was used to explore DPYSL2 expression and its connection to immune infiltrated cells. Through Gene Set Enrichment Analysis, the possible mechanism of DPYSL2 in LUAD was investigated. Results In this study, database analysis revealed lower DPYSL2 expression in LUAD than in normal tissues. The ROC curve suggested that expression of DPYSL2 had high diagnostic efficiency in LUAD. The DPYSL2 expression had an association with the survival time of LUAD patients in the Kaplan–Meier plotter and the Cox analyses. The results from TIMER depicted a markedly positive correlation of DPYSL2 expression with immune cells infiltrated in LUAD, such as macrophages, dendritic cells, CD4+ T cells, and neutrophils. Additionally, many gene markers for the immune system had similar positive correlations in the TIMER analysis. In Gene Set Enrichment Analysis, six immune-related signaling pathways were associated with DPYSL2. Conclusions In summary, DPYSL2 is a novel biomarker with diagnostic and prognostic potential for LUAD as well as an immunotherapy target. Highlights 1. Expression of DPYSL2 was considerably lower in LUAD than in normal tissues. 2. Investigation of multiple databases showed a high diagnostic value of DPYSL2 in LUAD. 3. DPYSL2 can independently predict the LUAD outcomes. 4. Immune-related mechanisms may be potential ways for DPYSL2 to play a role in LUAD.

Abstract Terpenoids, formed by cyclization and/or permutation of isoprenes, are the most diverse and abundant class of natural products with a broad range of significant functions. One family of the critical enzymes involved in terpenoid biosynthesis is terpene cyclases (TCs), also known as terpene synthases (TSs), which are responsible for forming the ring structure as a backbone of functionally diverse terpenoids. With the recent advances in biotechnology, the researches on terpene cyclases have gradually shifted from the genomic mining of novel enzyme resources to the analysis of their structures and mechanisms. In this review, we summarize both the new methods for genomic mining and the structural mechanisms of some typical terpene cyclases, which are helpful for the discovery, engineering and application of more and new TCs.

In the present study, the effect of elastomer ratios in solution-based mixtures on the formation of the phase structure and properties of compositions based on butyl rubber, chlorobutyl rubber, and ethylene-propylene-diene rubber was investigated. This work determined the influence of the elastomer ratios in uncured blends and their impact on the patterns of phase structure formation in multicomponent polymer systems, alterations in molecular mobility, and their influence on ozone resistance. Attenuated total reflectance – Fourier transform infrared spectroscopy was employed to analyze the chemical structure of the polymer surfaces. The influence of blend ratio (mass percentage ratios of 100/0, 80/20, 60/40, 50/50, 40/60, 20/80, and 0/100) on the phase structure and surface ozone oxidation was studied. The green strengths of the blends of ethylene-propylene-diene rubber and butyl/chlorobutyl rubbers were studied over a wide range of blend ratios. [ABSTRACT FROM AUTHOR]