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1. Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022.

Author

Kalonji, Thierry, Malembi, Emile, Matela, Jean, Likafi, Toutou, Kinganda-Lusamaki, Eddy, Vakaniaki, Emmanuel, Hoff, Nicole, Aziza, Amuri, Muyembe, Francisca, Kabamba, Joelle, Cooreman, Tine, Nguete, Béatrice, Witte, Danae, Ayouba, Ahidjo, Fernandez-Nuñez, Nicolas, Roge, Stijn, Peeters, Martine, Merritt, Sydney, Ahuka-Mundeke, Steve, Delaporte, Eric, Pukuta, Elisabeth, Mariën, Joachim, Bangwen, Eugene, Lakin, Steven, Lewis, Charles, Doty, Jeffrey, Liesenborghs, Laurens, Hensley, Lisa, McCollum, Andrea, Rimoin, Anne, Muyembe-Tamfum, Jean, Shongo, Robert, Kaba, Didine, and Mbala-Kingebeni, Placide

Subjects
Democratic Republic of the Congo, One Health, infectious diseases, monkeypox virus, mpox, orthopoxvirus, outbreak investigation, sexually transmitted infections, swinepox, swinepox virus, vector-borne infections, viruses, zoonoses, Humans, Animals, Swine, Mpox (monkeypox), Monkeypox virus, Suipoxvirus, Democratic Republic of the Congo, Poxviridae
Abstract

In September 2022, deaths of pigs manifesting pox-like lesions caused by swinepox virus were reported in Tshuapa Province, Democratic Republic of the Congo. Two human mpox cases were found concurrently in the surrounding community. Specific diagnostics and robust sequencing are needed to characterize multiple poxviruses and prevent potential poxvirus transmission.

Published
2024

2. An ounce of prevention is better: Monitoring wildlife health as a tool for pandemic prevention

Author

Gogarten, Jan Frederik, Düx, Ariane, Gräßle, Tobias, Lumbu, Christelle Patricia, Markert, Stephanie, Patrono, Livia Victoria, Pléh, Kamilla Anna, Singa, Frederic Niatou, Tanga, Coch Tanguy Floyde, Tombolomako, Thais Berenger, Couacy-Hymann, Emmanuel, Kouadio, Leonce, Ahuka-Mundeke, Steve, Makouloutou-Nzassi, Patrice, Calvignac-Spencer, Sébastien, and Leendertz, Fabian Hubertus

Published
2024
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3. Clade I-Associated Mpox Cases Associated with Sexual Contact, the Democratic Republic of the Congo.

Author

Bogoch, Isaac, Cevik, Muge, Gonsalves, Gregg, Hensley, Lisa, Low, Nicola, Shaw, Souradet, Schillberg, Erin, Hunter, Mikayla, Lunyanga, Lygie, Linsuke, Sylvie, Madinga, Joule, Peeters, Martine, Cigolo, Jean-Claude, Ahuka-Mundeke, Steve, Muyembe, Jean-Jacques, Rimoin, Anne, Kindrachuk, Jason, Mbala-Kingebeni, Placide, Lushima, Robert, Kibungu, Emile, Vakaniaki, Emmanuel, Kinganda-Lusamaki, Eddy, Kalonji-Mukendi, Thierry, Pukuta, Elisabeth, and Hoff, Nicole

Subjects
MPXV, monkeypox virus, mpox, sexually transmitted infections, the Democratic Republic of the Congo, viruses, Humans, Mpox (monkeypox), Monkeypox virus, Democratic Republic of the Congo, Polymerase Chain Reaction
Abstract

We report a cluster of clade I monkeypox virus infections linked to sexual contact in the Democratic Republic of the Congo. Case investigations resulted in 5 reverse transcription PCR-confirmed infections; genome sequencing suggest they belonged to the same transmission chain. This finding demonstrates that mpox transmission through sexual contact extends beyond clade IIb.

Published
2024

4. Clade I-Associated Mpox Cases Associated with Sexual Contact, the Democratic Republic of the Congo

Author

Kibungu, Emile M., Vakaniaki, Emmanuel H., Kinganda-Lusamaki, Eddy, Kalonji-Mukendi, Thierry, Pukuta, Elisabeth, Hoff, Nicole A., Bogoch, Isaac I., Cevik, Muge, Gonsalves, Gregg S., Hensley, Lisa E., Low, Nicola, Shaw, Souradet Y., Schillberg, Erin, Hunter, Mikayla, Lunyanga, Lygie, Linsuke, Sylvie, Madinga, Joule, Peeters, Martine, Cigolo, Jean-Claude Makangara, Ahuka-Mundeke, Steve, Muyembe, Jean- Jacques, Rimoin, Anne W., Kindrachuk, Jason, Mbala-Kingebeni, Placide, and Lushima, Robert S.

Subjects
Genomics, Infection, Disease transmission, Health
Abstract

Human mpox, caused by monkeypox virus (MPXV), is an emerging zoonotic viral disease first identified in the Democratic Republic of the Congo (DRC) (1). MPXV is endemic in multiple regions [...]

Published
2024
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5. COVID-19 seroprevalence cohort survey among health care workers and their household members in Kinshasa, DR Congo, 2020–2022

Author

Madinga, Joule, Mbala-Kingebeni, Placide, Nkuba-Ndaye, Antoine, Baketana-Kinzonzi, Leonel, Matungulu-Biyala, Elysé, Mutombo-Lupola, Patrick, Seghers, Caroline-Aurore, Smekens, Tom, Ariën, Kevin K., Van Damme, Wim, Kalk, Andreas, Peeters, Martine, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, and Vanlerberghe, Veerle

Published
2024
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6. Dysglycaemia in Ebola virus disease: a retrospective analysis from the 2018 to 2020 outbreak

Author

Claude, Kasereka Masumbuko, Mukadi-Bamuleka, Daniel, Richard, Kitenge-Omasumbu, Francois, Katsuva Mbahweka, Jean Paul, Paluku Mwalitsa, Muliwavyo, Kavugho, Edidi-Atani, François, Kuamfumu, Meris Matondo, Mulangu, Sabue, Tshiani-Mbaya, Olivier, Mbala-Kingebeni, Placide, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, Lee, Bonita E., Houston, Stan, Mumtaz, Zubia, and Hawkes, Michael T.

Published
2024
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7. Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study

Author

Shaw, Alexander G., Mampuela, Tresor Kabeya, Lofiko, Emmanuel Lokilo, Pratt, Catherine, Troman, Catherine, Bujaki, Erika, O’Toole, Áine, Akello, Joyce Odeke, Aziza, Adrienne Amuri, Lusamaki, Eddy Kinganda, Makangara, Jean Claude, Akonga, Marceline, Lay, Yvonne, Nsunda, Bibiche, White, Bailey, Jorgensen, David, Pukuta, Elizabeth, Riziki, Yogolelo, Rankin, Kathleen E., Rambaut, Andrew, Ahuka-Mundeke, Steve, Muyembe, Jean-Jacques, Martin, Javier, Grassly, Nicholas C., and Mbala-Kingebeni, Placide

Published
2023
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8. Seroprevalence of Bas-Congo virus in Mangala, Democratic Republic of the Congo: a population-based cross-sectional study

Author

Munyeku-Bazitama, Yannick, Okitale-Talunda, Patient, Hattori, Takanari, Saito, Takeshi, Lombe, Boniface Pongombo, Miyamoto, Hiroko, Mori-Kajihara, Akina, Kajihara, Masahiro, Nkoy, Agathe Bikupe, Twabela, Augustin Tshibwabwa, Masumu, Justin, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, Igarashi, Manabu, Park, Eun-sil, Morikawa, Shigeru, Makiala-Mandanda, Sheila, and Takada, Ayato

Published
2024
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10. Immunological response to fractional-dose yellow fever vaccine administered during an outbreak in Kinshasa, Democratic Republic of the Congo: results 5 years after vaccination from a prospective cohort study

Author

Doshi, Reena H, Mukadi, Patrick K, Casey, Rebecca M, Kizito, Gabriel M, Gao, Hongjiang, Nguete U, Beatrice, Laven, Janeen, Sabi, Lilliane, Kaba, Didine K, Muyembe-Tamfum, Jean-Jacques, Hyde, Terri B, Ahuka-Mundeke, Steve, and Staples, J Erin

Published
2024
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11. Immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccination in exposed and potentially exposed persons in the Democratic Republic of the Congo

Author

Hoff, Nicole A, Bratcher, Anna, Kelly, J Daniel, Musene, Kamy, Kompany, Jean Paul, Kabamba, Michel, Mbala-Kingebeni, Placide, Dighero-Kemp, Bonnie, Kocher, Gregory, Elliott, Elizabeth, Reilly, Cavan, Halbrook, Megan, Kebela, Benoit Ilunga, Gadoth, Adva, Mwamba, Guillaume Ngoie, Tambu, Merly, McIlwain, David R, Mukadi, Patrick, Hensley, Lisa E, Ahuka-Mundeke, Steve, Rutherford, George W, Muyembe-Tamfum, Jean Jacques, and Rimoin, Anne W

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Immunization, Emerging Infectious Diseases, Biodefense, Vaccine Related, Prevention, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral, Child, Democratic Republic of the Congo, Disease Outbreaks, Ebola Vaccines, Ebolavirus, Female, Glycoproteins, Hemorrhagic Fever, Ebola, Humans, Immunogenicity, Vaccine, Male, Middle Aged, Seroepidemiologic Studies, Vaccination, Viral Envelope Proteins, Young Adult, Ebola virus disease, Ebola vaccine, rVSV Delta G-ZEBOV-GP, immunogenicity, rVSVΔG-ZEBOV-GP
Abstract

Despite more than 300,000 rVSVΔG-ZEBOV-glycoprotein (GP) vaccine doses having been administered during Ebola virus disease (EVD) outbreaks in the Democratic Republic of the Congo (DRC) between 2018 and 2020, seroepidemiologic studies of vaccinated Congolese populations are lacking. This study examines the antibody response at 21 d and 6 mo postvaccination after single-dose rVSVΔG-ZEBOV-GP vaccination among EVD-exposed and potentially exposed populations in the DRC. We conducted a longitudinal cohort study of 608 rVSVΔG-ZEBOV-GP-vaccinated individuals during an EVD outbreak in North Kivu Province, DRC. Participants provided questionnaires and blood samples at three study visits (day 0, visit 1; day 21, visit 2; and month 6, visit 3). Anti-GP immunoglobulin G (IgG) antibody titers were measured in serum by the Filovirus Animal Nonclinical Group anti-Ebola virus GP IgG enzyme-linked immunosorbent assay. Antibody response was defined as an antibody titer that had increased fourfold from visit 1 to visit 2 and was above four times the lower limit of quantification at visit 2; antibody persistence was defined as a similar increase from visit 1 to visit 3. We then examined demographics for associations with follow-up antibody titers using generalized linear mixed models. A majority of the sample, 87.2%, had an antibody response at visit 2, and 95.6% demonstrated antibody persistence at visit 3. Being female and of young age was predictive of a higher antibody titer postvaccination. Antibody response and persistence after Ebola vaccination was robust in this cohort, confirming findings from outside of the DRC.

Published
2022

12. Effect of anti-Ebola virus monoclonal antibodies on endogenous antibody production in survivors of Ebola virus disease in the Democratic Republic of the Congo: an observational cohort study

Author

Ahuka-Mundeke, Steve, Bisento-Ngafa, Nella, Bulabula-Penge, Junior, Danga-Yema, Bernice, Eddi-Atani, François, Kinganda-Lusamaki, Eddy, Nkuba-Ndaye, Antoine, Mambu Mbika, Fabrice, Kabamba Lungenyi, Gabriel, Matondo Kiamfumu, Meris, Mbala-Kingebeni, Placide, Mukadi-Bamuleka, Daniel, Muyembe-Tamfum, Jean-Jacques, Delaporte, Eric, Ayouba, Ahidjo, Boullin, Julie, Dilu-Keti, Angèle, Lacroix, Audrey, Peeters, Martine, Pelloquin, Raphael, Thaurignac, Guillaume, Tovar Sanchez, Tamara, Kitenge, Richard, Formenty, Pierre, Legand, Anaïs, Panzi-Kalunda, Eric, Kakule-Sadiki, Callixte, Kambale-Kasyamboko, Guillaume, Kambale-Sivihwa, Nelson, Kavira-Muhesi, Sheila, Kavoyo-Mbayayi, Eli, Kitsa-Mutsumbirwa, Divine, Mbelu-Matulu, Fyfy, Mulopo-Mukanya, Noella, Mumbere-Kalemekwa, Elias, Defao, Paluku-Salambongo, Grace, Ekoko, Touré, Abdoulaye, Diallo, Mamadou Saliou Kalifa, Dilu-Keti, Angele, Tovar-Sanchez, Tamara, Edidi-Atani, François, and Toure, Abdoulaye

Published
2024
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13. 2020 Ebola virus disease outbreak in Équateur Province, Democratic Republic of the Congo: a retrospective genomic characterisation

Author

Kinganda-Lusamaki, Eddy, Whitmer, Shannon, Lokilo-Lofiko, Emmanuel, Amuri-Aziza, Adrienne, Muyembe-Mawete, Francisca, Makangara-Cigolo, Jean Claude, Makaya, Gerry, Mbuyi, Francis, Whitesell, Amy, Kallay, Ruth, Choi, Mary, Pratt, Catherine, Mukadi-Bamuleka, Daniel, Kavunga-Membo, Hugo, Matondo-Kuamfumu, Meris, Mambu-Mbika, Fabrice, Ekila-Ifinji, Richard, Shoemaker, Trevor, Stewart, Miles, Eng, Julia, Rajan, Abraham, Soke, Gnakub N, Fonjungo, Peter N, Otshudiema, John Otokoye, Folefack, Gervais Léon Tengomo, Pukuta-Simbu, Elisabeth, Talundzic, Emir, Shedroff, Elizabeth, Bokete, Jacques Likofata, Legand, Anaïs, Formenty, Pierre, Mores, Christopher N, Porzucek, Abigail J, Tritsch, Sarah R, Kombe, John, Tshapenda, Gaston, Mulangu, Felix, Ayouba, Ahidjo, Delaporte, Eric, Peeters, Martine, Wiley, Michael R, Montgomery, Joel M, Klena, John D, Muyembe-Tamfum, Jean-Jacques, Ahuka-Mundeke, Steve, and Mbala-Kingebeni, Placide

Published
2024
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14. Fatal meningoencephalitis associated with Ebola virus persistence in two survivors of Ebola virus disease in the Democratic Republic of the Congo: a case report study

Author

De Weggheleire, Anja, Soke, Gnakub N, Pallawo, Raymond, Ibrahima, Gouressy, Epaso Gelege, Victor, Kombe-Ngwama, John, Kahambwe-Ekoko, Grace, Mossoko Gbe, Mathias, Adikey Limne, Pierre-Céleste, Yuma-Kibondo, Etienne, Kinganda-Lusamaki, Eddy, Amuri Aziza, Adrienne, Tutu Tshia N'kasar, Yannick, Mumbere Kalemekwa, Elias, Kitsa-Mutsumbirwa, Divine, Mulopo-Mukanya, Noella, Mbelu-Matulu, Fyfy, Kavira-Muhindo, Marie-Anne, Kwizera Sendegeya, Jacques, Kavunga-Membo, Hugo, Mukadi-Bamuleka, Daniel, Edidi-Atani, François, Morales-Betoulle, Maria E, Legand, Anaïs, Nkuba-Ndaye, Antoine, Bulabula-Penge, Junior, Mbala-Kingebeni, Placide, Crozier, Ian, Mambu-Mbika, Fabrice, Whitmer, Shannon, Tshiani Mbaya, Olivier, Hensley, Lisa E, Kitenge-Omasumbu, Richard, Davey, Richard, Mulangu, Sabue, Fonjungo, Peter N, Wiley, Michael R, Klena, John D, Peeters, Martine, Delaporte, Eric, van Griensven, Johan, Ariën, Kevin K, Pratt, Catherine, Montgomery, Joel M, Formenty, Pierre, Muyembe-Tamfum, Jean-Jacques, and Ahuka-Mundeke, Steve

Published
2024
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15. High SARS-CoV-2 Seroprevalence after Second COVID-19 Wave (October 2020--April 2021), Democratic Republic of the Congo

Author

Munyeku-Bazitama, Yannick, Folefack, Gervais T., Yambayamba, Marc K., Tshiminyi, Paul M., Kazenza, Benito M., Otshudiema, John O., Guinko, Noe Tondri, Umba, Moreau D., Mulumba, Anastasie, Baketana, Lionel K., Mukadi, Patrick K., Smith, Chris, Muyembe-Tamfum, Jean-Jacques, Ahuka-Mundeke, Steve, and Makiala-Mandanda, Sheila

Subjects
Epidemics -- Surveys -- Risk factors -- Congo (Kinshasa), Health
Abstract

Two years after the first detected case of COVID-19 in Kinshasa, Democratic Republic of the Congo (DRC), the country experienced 4 subsequent waves of the virus, with peaks in June [...]

Published
2023
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16. Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease

Author

Mbala-Kingebeni, Placide, Pratt, Catherine, Ruffin, Mbusa Mutafali, Pauthner, Matthias G, Bile, Faustin, Ndaye, Antoine Nkuba, Black, Allison, Lusamaki, Eddy Kinganda, Faye, Martin, Aziza, Amuri, Diagne, Moussa M, Mukadi, Daniel, White, Bailey, Hadfield, James, Gangavarapu, Karthik, Bisento, Nella, Kazadi, Donatien, Nsunda, Bibiche, Akonga, Marceline, Tshiani, Olivier, Misasi, John, Ploquin, Aurelie, Epaso, Victor, Paka, Emilia Sana, N’kasar, Yannick Tutu Tshia, Mambu, Fabrice, Edidi, Francois, Matondo, Meris, Bula, Bula, Diallo, Boubacar, Keita, Mory, Belizaire, Marie Roseline Darnycka, Fall, Ibrahima Soce, Yam, Abdoulaye, Sabue, Mulangu, Rimion, Anne W, Salfati, Elias, Torkamani, Ali, Suchard, Marc A, Crozier, Ian, Hensley, Lisa, Rambaut, Andrew, Faye, Ousmane, Sall, Amadou, Sullivan, Nancy J, Bedford, Trevor, Andersen, Kristian G, Wiley, Michael R, Ahuka-Mundeke, Steve, and Tamfum, Jean-Jacques Muyembe

Subjects
Biodefense, Vaccine Related, Prevention, Infectious Diseases, Biotechnology, Rare Diseases, Emerging Infectious Diseases, Immunization, Infection, Good Health and Well Being, Adult, Bayes Theorem, Democratic Republic of the Congo, Ebola Vaccines, Ebolavirus, Fatal Outcome, Genome, Viral, Hemorrhagic Fever, Ebola, Humans, Male, Mutation, Phylogeny, RNA, Viral, Recurrence, Medical and Health Sciences, General & Internal Medicine
Abstract

During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus-based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)-specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We initiated epidemiologic and genomic investigations that showed that the patient had had a relapse of acute EVD that led to a transmission chain resulting in 91 cases across six health zones over 4 months. (Funded by the Bill and Melinda Gates Foundation and others.).

Published
2021

18. Head-to-head comparison of diagnostic accuracy of four Ebola virus disease rapid diagnostic tests versus GeneXpert® in eastern Democratic Republic of the Congo outbreaks: a prospective observational study

Author

Kavunga-Membo, Hgo, Ishara-Nshombo, Elie, Roge, Stijn, Mulopo-Mukanya, Noella, Tsiwedi-Tsilabia, Espérance, Muhindo-Milonde, Emile, Kavira-Muhindo, Marie-Anne, Morales-Betoulle, Maria E., Nkuba-Ndaye, Antoine, Mukadi-Bamuleka, Daniel, Bulabula-Penge, Junior, Jacobs, Bart K.M., De Weggheleire, Anja, Edidi-Atani, François, Mambu-Mbika, Fabrice, Legand, Anaïs, Klena, John D., Fonjungo, Peter N., Mbala-Kingebeni, Placide, Makiala-Mandanda, Sheila, Kajihara, Masahiro, Takada, Ayato, Montgomery, Joel M., Formenty, Pierre, Muyembe-Tamfum, Jean-Jacques, Ariën, Kevin K., van Griensven, Johan, and Ahuka-Mundeke, Steve

Published
2023
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19. A multi-country phase 2 study to evaluate the suitcase lab for rapid detection of SARS-CoV-2 in seven Sub-Saharan African countries: Lessons from the field

Author

Ceruti, Arianna, Dia, Ndongo, Bakarey, Adeleye Solomon, Ssekitoleko, Judah, Andriamandimby, Soa Fy, Malwengo-Kasongo, Padra, Ahmed, Rasheeda H.A., Kobialka, Rea Maja, Heraud, Jean Michel, Diagne, Moussa Moise, Dione, Marie Henriette Dior, Dieng, Idrissa, Faye, Martin, Faye, Ousmane, Rafisandratantsoa, Jean Théophile, Ravalohery, Jean-Pierre, Raharinandrasana, Claudio, Randriambolamanantsoa, Tsiry H., Razanajatovo, Norosoa, Razanatovo, Iony, Rabarison, Joelinotahina H., Dussart, Phillipe, Kyei-Tuffuor, Louis, Agbanyo, Abigail, Adewumi, Olubusuyi Moses, Fowotade, Adeola, Raifu, Muideen Kolawole, Okitale-Talunda, Patient, Kashitu-Mujinga, Gracia, Mbelu-Kabongo, Christelle, Ahuka-Mundeke, Steve, Makaka-Mutondo, Anguy, Abdalla, Enas M., Idris, Sanaa M., Elmagzoub, Wisal A., Ali, Rahma H., Nour, Eman O.M., Ebraheem, Rasha S.M., Ahmed, Huda H.H., Abdalla, Hamadelniel E., Elnegoumi, Musab, Mukhtar, Izdihar, Adam, Muatsim A.M., Mohamed, Nuha Y.I., Bedri, Shahinaz A., Hamdan, Hamdan Mustafa, Kisekka, Magid, Mpumwiire, Monica, Aloyo, Sharley Melissa, Wandera, Joanita Nabwire, Agaba, Andrew, Kamulegeya, Rogers, Kiprotich, Hosea, Kateete, David Patrick, Kadetz, Paul, Truyen, Uwe, Eltom, Kamal H., Sakuntabhai, Anavaj, Okuni, Julius Boniface, Makiala-Mandanda, Sheila, Lacoste, Vincent, Ademowo, George Olusegun, Frimpong, Michael, Sall, Amadou Alpha, Weidmann, Manfred, and Abd El Wahed, Ahmed

Published
2023
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20. Responding to the Challenge of the Dual COVID-19 and Ebola Epidemics in the Democratic Republic of Congo-Priorities for Achieving Control.

Author

Nachega, Jean, Mbala-Kingebeni, Placide, Otshudiema, John, Mobula, Linda, Preiser, Wolfgang, Kallay, Oscar, Michaels-Strasser, Susan, Breman, Joel, Rimoin, Anne, Nsio, Justus, Ahuka-Mundeke, Steve, Zumla, Alimuddin, and Muyembe Tam-Fum, Jean-Jacques

Subjects
Betacoronavirus, COVID-19, Case Management, Contact Tracing, Coronavirus Infections, Delivery of Health Care, Democratic Republic of the Congo, Health Communication, Hemorrhagic Fever, Ebola, Humans, Pandemics, Pneumonia, Viral, SARS-CoV-2
Abstract

As of June 11, 2020, the Democratic Republic of the Congo (DRC) has reported 4,258 COVID-19 cases with 90 deaths. With other African countries, the DRC faces the challenge of striking a balance between easing public health lockdown measures to curtail the spread of SARS-CoV-2 and minimizing both economic hardships for large sectors of the population and negative impacts on health services for other infectious and noninfectious diseases. The DRC recently controlled its tenth Ebola virus disease (EVD) outbreak, but COVID-19 and a new EVD outbreak beginning on June 1, 2020 in the northwest Équateur Province have added an additional burden to health services. Although the epidemiology and transmission of EVD and COVID-19 differ, leveraging the public health infrastructures and experiences from coordinating the EVD response to guide the public health response to COVID-19 is critical. Building on the DRCs 40 years of experience with 10 previous EVD outbreaks, we highlight the DRCs multi-sectoral public health approach to COVID-19, which includes community-based screening, testing, contact-tracing, risk communication, community engagement, and case management. We also highlight remaining challenges and discuss the way forward for achieving control of both COVID-19 and EVD in the DRC.

Published
2020

21. Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance.

Author

Deng, Xianding, Achari, Asmeeta, Federman, Scot, Yu, Guixia, Somasekar, Sneha, Bártolo, Inês, Yagi, Shigeo, Mbala-Kingebeni, Placide, Kapetshi, Jimmy, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, Ahmed, Asim A, Ganesh, Vijay, Tamhankar, Manasi, Patterson, Jean L, Ndembi, Nicaise, Mbanya, Dora, Kaptue, Lazare, McArthur, Carole, Muñoz-Medina, José E, Gonzalez-Bonilla, Cesar R, López, Susana, Arias, Carlos F, Arevalo, Shaun, Miller, Steve, Stone, Mars, Busch, Michael, Hsieh, Kristina, Messenger, Sharon, Wadford, Debra A, Rodgers, Mary, Cloherty, Gavin, Faria, Nuno R, Thézé, Julien, Pybus, Oliver G, Neto, Zoraima, Morais, Joana, Taveira, Nuno, R Hackett, John, and Chiu, Charles Y

Subjects
Humans, Viruses, Dengue Virus, Chikungunya virus, Virus Diseases, Dengue, Yellow Fever, Hemorrhagic Fever, Ebola, DNA, Viral, RNA, Viral, Polymerase Chain Reaction, Computational Biology, Genome, Viral, Ebolavirus, Metagenome, Metagenomics, High-Throughput Nucleotide Sequencing, Zika Virus, Zika Virus Infection, Microbiology, Medical Microbiology
Abstract

Metagenomic next-generation sequencing (mNGS), the shotgun sequencing of RNA and DNA from clinical samples, has proved useful for broad-spectrum pathogen detection and the genomic surveillance of viral outbreaks. An additional target enrichment step is generally needed for high-sensitivity pathogen identification in low-titre infections, yet available methods using PCR or capture probes can be limited by high cost, narrow scope of detection, lengthy protocols and/or cross-contamination. Here, we developed metagenomic sequencing with spiked primer enrichment (MSSPE), a method for enriching targeted RNA viral sequences while simultaneously retaining metagenomic sensitivity for other pathogens. We evaluated MSSPE for 14 different viruses, yielding a median tenfold enrichment and mean 47% (±16%) increase in the breadth of genome coverage over mNGS alone. Virus detection using MSSPE arboviral or haemorrhagic fever viral panels was comparable in sensitivity to specific PCR, demonstrating 95% accuracy for the detection of Zika, Ebola, dengue, chikungunya and yellow fever viruses in plasma samples from infected patients. Notably, sequences from re-emerging and/or co-infecting viruses that have not been specifically targeted a priori, including Powassan and Usutu, were successfully enriched using MSSPE. MSSPE is simple, low cost, fast and deployable on either benchtop or portable nanopore sequencers, making this method directly applicable for diagnostic laboratory and field use.

Published
2020

22. Author Correction: Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance

Author

Deng, Xianding, Achari, Asmeeta, Federman, Scot, Yu, Guixia, Somasekar, Sneha, Bártolo, Inês, Yagi, Shigeo, Mbala-Kingebeni, Placide, Kapetshi, Jimmy, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, Ahmed, Asim A, Ganesh, Vijay, Tamhankar, Manasi, Patterson, Jean L, Ndembi, Nicaise, Mbanya, Dora, Kaptue, Lazare, McArthur, Carole, Muñoz-Medina, José E, Gonzalez-Bonilla, Cesar R, López, Susana, Arias, Carlos F, Arevalo, Shaun, Miller, Steve, Stone, Mars, Busch, Michael, Hsieh, Kristina, Messenger, Sharon, Wadford, Debra A, Rodgers, Mary, Cloherty, Gavin, Faria, Nuno R, Thézé, Julien, Pybus, Oliver G, Neto, Zoraima, Morais, Joana, Taveira, Nuno, Hackett, John R, and Chiu, Charles Y

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Good Health and Well Being, Microbiology, Medical Microbiology
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

23. Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa.

Author

Faria, Nuno R, Vidal, Nicole, Lourenco, José, Raghwani, Jayna, Sigaloff, Kim CE, Tatem, Andy J, van de Vijver, David AM, Pineda-Peña, Andrea-Clemencia, Rose, Rebecca, Wallis, Carole L, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, Muwonga, Jérémie, Suchard, Marc A, Rinke de Wit, Tobias F, Hamers, Raph L, Ndembi, Nicaise, Baele, Guy, Peeters, Martine, Pybus, Oliver G, Lemey, Philippe, and Dellicour, Simon

Subjects
Humans, HIV-1, HIV Infections, Africa, Central, Africa, Eastern, Africa, Central, Eastern, Virology, Microbiology, Immunology, Medical Microbiology
Abstract

Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have spread heterogeneously throughout the world. Subtype C spread rapidly through sub-Saharan Africa and is currently the dominant HIV lineage worldwide. Yet the epidemiological and evolutionary circumstances that contributed to its epidemiological expansion remain poorly understood. Here, we analyse 346 novel pol sequences from the DRC to compare the evolutionary dynamics of the main HIV-1 lineages, subtypes A1, C and D. Our results place the origins of subtype C in the 1950s in Mbuji-Mayi, the mining city of southern DRC, while subtypes A1 and D emerged in the capital city of Kinshasa, and subtypes H and J in the less accessible port city of Matadi. Following a 15-year period of local transmission in southern DRC, we find that subtype C spread at least three-fold faster than other subtypes circulating in Central and East Africa. In conclusion, our results shed light on the origins of HIV-1 main lineages and suggest that socio-historical rather than evolutionary factors may have determined the epidemiological fate of subtype C in sub-Saharan Africa.

Published
2019

24. Differential symptomology of possible and confirmed Ebola virus disease infection in the Democratic Republic of the Congo: a retrospective cohort study

Author

Nsio, Justus, Ardiet, Denis-Luc, Coulborn, Rebecca M, Grellety, Emmanuel, Albela, Manuel, Grandesso, Francesco, Kitenge, Richard, Ngwanga, Dolla L, Matady, Bibiche, Manangama, Guyguy, Mossoko, Mathias, Ngwama, John Kombe, Mbala, Placide, Luquero, Francisco, Porten, Klaudia, and Ahuka-Mundeke, Steve

Published
2023
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25. Epidemiological Comparison of Four COVID-19 Waves in the Democratic Republic of the Congo, March 2020–January 2022

Author

Otshudiema, John Otokoye, Folefack, Gervais Léon T., Nsio, Justus M., Mbala-Kingebeni, Placide, Kakema, Cathy H., Kosianza, Joel B., Mfumu, Antoine K., Saidi, Guy N., Kabongo, Patrice M., Okum, Raphael, Tshimbombu, Tshibambe N., Ahuka-Mundeke, Steve, Karamagi, Humphrey Cyprian, Muyembe, Jean-Jacques T., and Djiguimde, Amédée Prosper

Published
2022
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26. Sustained Human Outbreak of a New MPXV Clade I Lineage in Eastern Democratic Republic of the Congo

Author

Vakaniaki, Emmanuel H., primary, Kaciat, Cris, additional, Kinganda-Lusamaki, Eddy, additional, O'Toole, Aine, additional, Wawina-Bokalanga, Tony, additional, Mukadi-Bamuleka, Daniel, additional, Aziza, Adrienne Amuri, additional, Malyamungu-Bubala, Nadine, additional, Mweshi-Kumbana, Francklin, additional, Mutimbwa-Mambo, Leandre, additional, Belesi-Siangoli, Freddy, additional, Mujula, Yves, additional, Parker, Edyth, additional, Muswamba-Kayembe, Pauline-Chloe, additional, Nundu, Sabin S., additional, Lushima, Robert S., additional, Cigolo, Jean Claude Makangara, additional, Mulopo-Mukanya, Noella, additional, Simbu, Elisabeth Pukuta, additional, Akil-Bandali, Prince, additional, Kavunga, Hugo, additional, Vercauteren, Koen, additional, Sam-Agudu, Nadia A., additional, Mills, Edward J, additional, Tshiani-Mbaya, Olivier, additional, Hoff, Nicole A., additional, Rimoin, Anne W, additional, Hensley, Lisa E., additional, Kindrachuk, Jason, additional, Ayouba, Ahidjo, additional, Peeters, Martine, additional, Delaporte, Eric, additional, Ahuka-Mundeke, Steve, additional, Nachega, Jean B., additional, Muyembe, Jean-Jacques Tamfum, additional, Rambaut, Andrew, additional, Liesenborghs, Laurens, additional, and Mbala-Kingebeni, Placide, additional

Published
2024
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27. Virus kinetics and biochemical derangements among children with Ebolavirus disease

Author

Kjaldgaard, Lindsey, Claude, Kasereka Masumbuko, Mukadi-Bamuleka, Daniel, Kitenge-Omasumbu, Richard, Dixit, Devika, Edidi-Atani, François, Kuamfumu, Meris Matondo, Bulabula-Penge, Junior, Mambu-Mbika, Fabrice, Tshiani-Mbaya, Olivier, Diaz, Janet, Mulangu, Sabue, Legand, Anais, Mbala-Kingebeni, Placide, Formenty, Pierre, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, and Hawkes, Michael T.

Published
2022
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28. Real-time predictions of the 2018-2019 Ebola virus disease outbreak in the Democratic Republic of the Congo using Hawkes point process models.

Author

Kelly, J Daniel, Park, Junhyung, Harrigan, Ryan J, Hoff, Nicole A, Lee, Sarita D, Wannier, Rae, Selo, Bernice, Mossoko, Mathias, Njoloko, Bathe, Okitolonda-Wemakoy, Emile, Mbala-Kingebeni, Placide, Rutherford, George W, Smith, Thomas B, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean Jacques, Rimoin, Anne W, and Schoenberg, Frederic Paik

Subjects
Humans, Hemorrhagic Fever, Ebola, Data Collection, Models, Statistical, Prospective Studies, Decision Making, Disease Outbreaks, Models, Theoretical, Time, Democratic Republic of the Congo, Ebolavirus, Compartmental models, Democratic Republic of Congo, Ebola virus disease, Hawkes point process, Mathematical modeling, Clinical Sciences, Public Health and Health Services
Abstract

As of June 16, 2019, an Ebola virus disease (EVD) outbreak has led to 2136 reported cases in the northeastern region of the Democratic Republic of the Congo (DRC). As this outbreak continues to threaten the lives and livelihoods of people already suffering from civil strife and armed conflict, relatively simple mathematical models and their short-term predictions have the potential to inform Ebola response efforts in real time. We applied recently developed non-parametrically estimated Hawkes point processes to model the expected cumulative case count using daily case counts from May 3, 2018, to June 16, 2019, initially reported by the Ministry of Health of DRC and later confirmed in World Health Organization situation reports. We generated probabilistic estimates of the ongoing EVD outbreak in DRC extending both before and after June 16, 2019, and evaluated their accuracy by comparing forecasted vs. actual outbreak sizes, out-of-sample log-likelihood scores and the error per day in the median forecast. The median estimated outbreak sizes for the prospective thee-, six-, and nine-week projections made using data up to June 16, 2019, were, respectively, 2317 (95% PI: 2222, 2464); 2440 (95% PI: 2250, 2790); and 2544 (95% PI: 2273, 3205). The nine-week projection experienced some degradation with a daily error in the median forecast of 6.73 cases, while the six- and three-week projections were more reliable, with corresponding errors of 4.96 and 4.85 cases per day, respectively. Our findings suggest the Hawkes point process may serve as an easily-applied statistical model to predict EVD outbreak trajectories in near real-time to better inform decision-making and resource allocation during Ebola response efforts.

Published
2019

29. Metagenomic Next-Generation Sequencing of the 2014 Ebola Virus Disease Outbreak in the Democratic Republic of the Congo

Author

Li, Tony, Mbala-Kingebeni, Placide, Naccache, Samia N, Thézé, Julien, Bouquet, Jerome, Federman, Scot, Somasekar, Sneha, Yu, Guixia, Sanchez-San Martin, Claudia, Achari, Asmeeta, Schneider, Bradley S, Rimoin, Anne W, Rambaut, Andrew, Nsio, Justus, Mulembakani, Prime, Ahuka-Mundeke, Steve, Kapetshi, Jimmy, Pybus, Oliver G, Muyembe-Tamfum, Jean-Jacques, and Chiu, Charles Y

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Prevention, Emerging Infectious Diseases, Vector-Borne Diseases, Biodefense, Vaccine Related, Rare Diseases, Genetics, Aetiology, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Adult, Coinfection, Democratic Republic of the Congo, Disease Outbreaks, Ebolavirus, Female, Hemorrhagic Fever, Ebola, High-Throughput Nucleotide Sequencing, Humans, Infant, Male, Metagenomics, Middle Aged, Young Adult, Boende outbreak, Orungo virus, coinfection, Ebola virus, molecular clock analysis, next-generation sequencing, pathogen discovery, phylogenetic analysis, viral genome assembly, viral metagenomics, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Microbiology, Clinical sciences, Medical microbiology
Abstract

We applied metagenomic next-generation sequencing (mNGS) to detect Zaire Ebola virus (EBOV) and other potential pathogens from whole-blood samples from 70 patients with suspected Ebola hemorrhagic fever during a 2014 outbreak in Boende, Democratic Republic of the Congo (DRC) and correlated these findings with clinical symptoms. Twenty of 31 patients (64.5%) tested in Kinshasa, DRC, were EBOV positive by quantitative reverse transcriptase PCR (qRT-PCR). Despite partial degradation of sample RNA during shipping and handling, mNGS followed by EBOV-specific capture probe enrichment in a U.S. genomics laboratory identified EBOV reads in 22 of 70 samples (31.4%) versus in 21 of 70 (30.0%) EBOV-positive samples by repeat qRT-PCR (overall concordance = 87.1%). Reads from Plasmodium falciparum (malaria) were detected in 21 patients, of which at least 9 (42.9%) were coinfected with EBOV. Other positive viral detections included hepatitis B virus (n = 2), human pegivirus 1 (n = 2), Epstein-Barr virus (n = 9), and Orungo virus (n = 1), a virus in the Reoviridae family. The patient with Orungo virus infection presented with an acute febrile illness and died rapidly from massive hemorrhage and dehydration. Although the patient's blood sample was negative by EBOV qRT-PCR testing, identification of viral reads by mNGS confirmed the presence of EBOV coinfection. In total, 9 new EBOV genomes (3 complete genomes, and an additional 6 ≥50% complete) were assembled. Relaxed molecular clock phylogenetic analysis demonstrated a molecular evolutionary rate for the Boende strain 4 to 10× slower than that of other Ebola lineages. These results demonstrate the utility of mNGS in broad-based pathogen detection and outbreak surveillance.

Published
2019

30. Estimating the impact of violent events on transmission in Ebola virus disease outbreak, Democratic Republic of the Congo, 2018-2019.

Author

Wannier, S Rae, Worden, Lee, Hoff, Nicole A, Amezcua, Eduardo, Selo, Bernice, Sinai, Cyrus, Mossoko, Mathias, Njoloko, Bathe, Okitolonda-Wemakoy, Emile, Mbala-Kingebeni, Placide, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean Jacques, Richardson, Eugene T, Rutherford, George W, Jones, James H, Lietman, Thomas M, Rimoin, Anne W, Porco, Travis C, and Kelly, J Daniel

Subjects
Humans, Hemorrhagic Fever, Ebola, Disease Outbreaks, Time, Violence, Democratic Republic of the Congo, Africa, Democratic Republic of Congo, Ebola virus disease, Geospatial, Mathematical modeling, Outbreak, Biodefense, Infectious Diseases, Emerging Infectious Diseases, Prevention, Violence Research, Vaccine Related, Infection, Clinical Sciences, Public Health and Health Services
Abstract

IntroductionAs of April 2019, the current Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo (DRC) is occurring in a longstanding conflict zone and has become the second largest EVD outbreak in history. It is suspected that after violent events occur, EVD transmission will increase; however, empirical studies to understand the impact of violence on transmission are lacking. Here, we use spatial and temporal trends of EVD case counts to compare transmission rates between health zones that have versus have not experienced recent violent events during the outbreak.MethodsWe collected daily EVD case counts from DRC Ministry of Health. A time-varying indicator of recent violence in each health zone was derived from events documented in the WHO situation reports. We used the Wallinga-Teunis technique to estimate the reproduction number R for each case by day per zone in the 2018-2019 outbreak. We fit an exponentially decaying curve to estimates of R overall and by health zone, for comparison to past outbreaks.ResultsAs of 16 April 2019, the mean overall R for the entire outbreak was 1.11. We found evidence of an increase in the estimated transmission rates in health zones with recently reported violent events versus those without (p = 0.008). The average R was estimated as between 0.61 and 0.86 in regions not affected by recent violent events, and between 1.01 and 1.07 in zones affected by violent events within the last 21 days, leading to an increase in R between 0.17 and 0.53. Within zones with recent violent events, the mean estimated quenching rate was lower than for all past outbreaks except the 2013-2016 West African outbreak.ConclusionThe difference in the estimated transmission rates between zones affected by recent violent events suggests that violent events are contributing to increased transmission and the ongoing nature of this outbreak.

Published
2019

31. Postmortem Surveillance for Ebola Virus Using OraQuick Ebola Rapid Diagnostic Tests, Eastern Democratic Republic of the Congo, 2019-2020

Author

Mukadi-Bamuleka, Daniel, Sanogo, Yibayiri Osee, Bulabula-Penge, Junior, Morales-Betoulle, Maria E., Fillon, Patrice, Woodruff, Patrick, Choi, Mary J., Whitesell, Amy, Todres, Alison M., De Weggheleire, Anja, Legand, Anais, Muyembe-Tamfum, Jean-Jacques, Formenty, Pierre, Klena, John D., Montgomery, Joel M., and Ahuka-Mundeke, Steve

Subjects
Ebola virus infections -- Patient outcomes -- Diagnosis, Autopsy -- Methods, Molecular diagnostic techniques -- Usage, Ebola virus -- Identification and classification, Health
Abstract

The 10th outbreak of Ebola virus (EBOV) disease (EVD) in North Kivu, Democratic Republic of the Congo (DRC), was the longest (August 1, 2018-July 25, 2020) and largest EVD outbreak [...]

Published
2022
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32. Field performance of three Ebola rapid diagnostic tests used during the 2018–20 outbreak in the eastern Democratic Republic of the Congo: a retrospective, multicentre observational study

Author

Mukadi-Bamuleka, Daniel, Bulabula-Penge, Junior, De Weggheleire, Anja, Jacobs, Bart K M, Edidi-Atani, François, Mambu-Mbika, Fabrice, Mbala-Kingebeni, Placide, Makiala-Mandanda, Sheila, Faye, Martin, Diagne, Cheick T, Diagne, Moussa M, Faye, Oumar, Kajihara, Masahiro, Faye, Ousmane, Takada, Ayato, Sall, Amadou A, Muyembe-Tamfum, Jean-Jacques, van Griensven, Johan, Ariën, Kevin K, and Ahuka-Mundeke, Steve

Published
2022
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33. Rhabdomyolysis, Acute Kidney Injury, and Mortality in Ebola Virus Disease: Retrospective Analysis of Cases From the Eastern Democratic Republic of the Congo, 2019.

Author

Kasereka, Masumbuko Claude, Mukadi-Bamuleka, Daniel, Kitenge-Omasumbu, Richard, Edidi-Atani, François, Kuamfumu, Meris Matondo, Mulangu, Sabue, Tshiani-Mbaya, Olivier, Vicky, Kambale Malengera, Mbala-Kingebeni, Placide, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, Lee, Bonita E, Houston, Stan, Mumtaz, Zubia, and Hawkes, Michael T

Subjects
EBOLA virus disease, ACUTE kidney failure, CREATINE kinase, RHABDOMYOLYSIS, ODDS ratio
Abstract

Background Skeletal muscle injury in Ebola virus disease (EVD) has been reported, but its association with morbidity and mortality remains poorly defined. Methods This retrospective study included patients admitted to 2 EVD treatment units over an 8-month period in 2019 during an EVD epidemic in the Democratic Republic of the Congo. Results An overall 333 patients (median age, 30 years; 58% female) had at least 1 creatine kinase (CK) measurement (n = 2229; median, 5/patient [IQR, 1–11]). Among patients, 271 (81%) had an elevated CK level (>380 U/L); 202 (61%) had rhabdomyolysis (CK >1000 IU/L); and 45 (14%) had severe rhabdomyolysis (≥5000 U/L). Among survivors, the maximum CK level was a median 1600 (IQR, 550–3400), peaking 3.4 days after admission (IQR, 2.3–5.5) and decreasing thereafter. Among fatal cases, the CK rose monotonically until death, with a median maximum CK level of 2900 U/L (IQR, 1500–4900). Rhabdomyolysis at admission was an independent predictor of acute kidney injury (adjusted odds ratio, 2.2 [95% CI, 1.2–3.8]; P =.0065) and mortality (adjusted hazard ratio, 1.7 [95% CI, 1.03–2.9]; P =.037). Conclusions Rhabdomyolysis is associated with acute kidney injury and mortality in patients with EVD. These findings may inform clinical practice by identifying laboratory monitoring priorities and highlighting the importance of fluid management. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Synergistic effects of novel penicillin-binding protein 1A amino acid substitutions contribute to high-level amoxicillin resistance of Helicobacter pylori.

Author

Cimuanga-Mukanya, Alain, Tshibangu-Kabamba, Evariste, Kisoko, Patrick de Jesus Ngoma, Fauzia, Kartika Afrida, Tshibangu, Fabien Mbaya, Wola, Antoine Tshimpi, Kashala, Pascal Tshiamala, Ngoyi, Dieudonné Mumba, Ahuka-Mundeke, Steve, Revathi, Gunturu, Disashi-Tumba, Ghislain, Yasutoshi Kido, Takashi Matsumoto, Junko Akada, and Yoshio Yamaoka

Published
2024
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35. Knowledge, attitudes, practices, and perception of COVID-19 preventive measures among adult residents of Matadi (Democratic Republic of the Congo) after the third epidemic wave.

Author

Munyeku-Bazitama, Yannick, Okitale-Talunda, Patient, Nsio-Mbeta, Justus, Mpingabo-Ilunga, Patrick, Tshiminyi-Munkamba, Paul, Umba-Phuati, Aimé, Kimfuta, Jacques, Ango-Phukuta, Ferdinand, Makindu, Goethe, Mufwaya-Nsene, Raymond, Ryoko Asari, Saeda Makimoto, Ahuka-Mundeke, Steve, Mitsuo Isono, Makiala-Mandanda, Sheila, and Muyembe-Tamfum, Jean-Jacques

Published
2024
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36. Novel Use of Capture-Recapture Methods to Estimate Completeness of Contact Tracing during an Ebola Outbreak, Democratic Republic of the Congo, 2018-2020

Author

Polonsky, Jonathan A., Bohning, Dankmar, Keita, Mory, Ahuka-Mundeke, Steve, Nsio-Mbeta, Justus, Abedi, Aaron Aruna, Mossoko, Mathias, Estill, Janne, Keiser, Olivia, Kaiser, Laurent, Yoti, Zabulon, Sangnawakij, Patarawan, Lerdsuwansri, Rattana, and Del Rio Vilas, Victor J.

Subjects
Epidemics -- Statistics -- Control -- Congo (Kinshasa), Ebola virus infections -- Statistics -- Control, Contact tracing -- Methods -- Evaluation, Health
Abstract

Contact tracing is the process by which persons who are believed to have come into contact with a confirmed case-patient with an infectious disease during the infectious period are located [...]

Published
2021
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37. Evaluation of Early Warning, Alert and Response System for Ebola Virus Disease, Democratic Republic of the Congo, 2018-2020

Author

Keita, Mory, Lucaccioni, Heloise, Ilumbulumbu, Michel Kalongo, Polonsky, Jonathan, Nsio-Mbeta, Justus, Panda, Gaston Tshapenda, Adikey, Pierre Celeste, Ngwama, John Kombe, Tosalisana, Michel Kasereka, Diallo, Boubacar, Subissi, Lorenzo, Dakissaga, Adama, Finci, Iris, de Almeida, Maria Moitinho, Guha-Sapir, Debarati, Talisuna, Ambrose, Delamou, Alexandre, Dagron, Stephanie, Keiser, Olivia, and Ahuka-Mundeke, Steve

Subjects
Epidemics -- Statistics -- Risk factors -- Control -- Congo (Kinshasa), Ebola virus infections -- Statistics -- Risk factors -- Control, Sentinel health events -- Methods, Health
Abstract

Early case detection is important to control and prevent infectious disease outbreaks (1). The 5 identified purposes for early detection surveillance are detecting the first case of the disease in [...]

Published
2021
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38. Detection of the Lassa Virus in a Group of Odontogenic Bone Tumor Tissues

Author

de Feo, Marco, primary, Dilu Tamba, Frédéric, additional, Makaka Mutondo, Anguy, additional, Kashitu Mujinga, Gracia, additional, Odong, Opiyo Stephen, additional, Castellani, Chiara, additional, Pavesi, Luca, additional, Mpingabo, Patrick I., additional, Ahuka-Mundeke, Steve, additional, and Di Agostino, Silvia, additional

Published
2024
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39. Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey Report

Author

Matungala-Pafubel, Mathy, primary, Bulabula-Penge, Junior, additional, Matondo-Kuamfumu, Meris, additional, Esala, Samy, additional, Edidi-Atani, François, additional, Pukuta-Simbu, Elisabeth, additional, Tshiminyi-Munkamba, Paul, additional, Tutu Tshia N’kasar, Yannick, additional, Katanga, Trésor, additional, Ndomba-Mukanya, Etienne, additional, Mbonga-Mande, Delphine, additional, Baketana-Kinzonzi, Lionel, additional, Kinganda-Lusamaki, Eddy, additional, Mukadi-Bamuleka, Daniel, additional, Mambu-Mbika, Fabrice, additional, Mbala-Kingebeni, Placide, additional, Nkwembe-Ngabana, Edith, additional, Nkuba-Ndaye, Antoine, additional, Okitundu-Luwa, Daniel, additional, and Ahuka-Mundeke, Steve, additional

Published
2024
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41. Ebola Virus Disease Outbreak — Democratic Republic of the Congo, August 2018–November 2019

Author

CDC Ebola Response, Aruna, Aaron, Mbala, Placide, Minikulu, Luigi, Mukadi, Daniel, Bulemfu, Dorothée, Edidi, Franck, Bulabula, Junior, Tshapenda, Gaston, Nsio, Justus, Kitenge, Richard, Mbuyi, Gisèle, Mwanzembe, Celestin, Kombe, John, Lubula, Léopold, Shako, Jean Christophe, Mossoko, Mathias, Mulangu, Felix, Mutombo, Annie, Sana, Emilia, Tutu, Yannick, Kabange, Laetycia, Makengo, Jonathan, Tshibinkufua, Fortunat, Ahuka-Mundeke, Steve, and Muyembe, Jean-Jacques

Published
2019

42. Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo

Author

Kinganda-Lusamaki, Eddy, Black, Allison, Mukadi, Daniel B., Hadfield, James, Mbala-Kingebeni, Placide, Pratt, Catherine B., Aziza, Amuri, Diagne, Moussa M., White, Bailey, Bisento, Nella, Nsunda, Bibiche, Akonga, Marceline, Faye, Martin, Faye, Ousmane, Edidi-Atani, Francois, Matondo-Kuamfumu, Meris, Mambu-Mbika, Fabrice, Bulabula, Junior, Di Paola, Nicholas, Pauthner, Matthias G., Andersen, Kristian G., Palacios, Gustavo, Delaporte, Eric, Sall, Amadou Alpha, Peeters, Martine, Wiley, Michael R., Ahuka-Mundeke, Steve, Bedford, Trevor, and Tamfum, Jean-Jacques Muyembe

Published
2021
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43. Cost-effectiveness of incorporating Ebola prediction score tools and rapid diagnostic tests into a screening algorithm: A decision analytic model

Author

Tshomba, Antoine Oloma, primary, Mukadi-Bamuleka, Daniel, additional, De Weggheleire, Anja, additional, Tshiani, Olivier M., additional, Kayembe, Charles T., additional, Mbala-Kingebeni, Placide, additional, Muyembe-Tamfum, Jean-Jacques, additional, Ahuka-Mundeke, Steve, additional, Chenge, Faustin M., additional, Jacobs, Bart Karl M., additional, Mumba, Dieudonné N., additional, Tshala-Katumbay, Désiré D., additional, and Mulangu, Sabue, additional

Published
2023
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46. Real-time predictions of the 2018–2019 Ebola virus disease outbreak in the Democratic Republic of the Congo using Hawkes point process models

Author

Kelly, J. Daniel, Park, Junhyung, Harrigan, Ryan J., Hoff, Nicole A., Lee, Sarita D., Wannier, Rae, Selo, Bernice, Mossoko, Mathias, Njoloko, Bathe, Okitolonda-Wemakoy, Emile, Mbala-Kingebeni, Placide, Rutherford, George W., Smith, Thomas B., Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean Jacques, Rimoin, Anne W., and Schoenberg, Frederic Paik

Published
2019
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47. Estimating the impact of violent events on transmission in Ebola virus disease outbreak, Democratic Republic of the Congo, 2018–2019

Author

Wannier, S. Rae, Worden, Lee, Hoff, Nicole A., Amezcua, Eduardo, Selo, Bernice, Sinai, Cyrus, Mossoko, Mathias, Njoloko, Bathe, Okitolonda-Wemakoy, Emile, Mbala-Kingebeni, Placide, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean Jacques, Richardson, Eugene T., Rutherford, George W., Jones, James H, Lietman, Thomas M., Rimoin, Anne W., Porco, Travis C., and Kelly, J. Daniel

Published
2019
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48. 2018 Ebola virus disease outbreak in Équateur Province, Democratic Republic of the Congo: a retrospective genomic characterisation

Author

Mbala-Kingebeni, Placide, Pratt, Catherine B, Wiley, Michael R, Diagne, Moussa M, Makiala-Mandanda, Sheila, Aziza, Amuri, Di Paola, Nicholas, Chitty, Joseph A, Diop, Mamadou, Ayouba, Ahidjo, Vidal, Nicole, Faye, Ousmane, Faye, Oumar, Karhemere, Stormy, Aruna, Aaron, Nsio, Justus, Mulangu, Felix, Mukadi, Daniel, Mukadi, Patrick, Kombe, John, Mulumba, Anastasie, Duraffour, Sophie, Likofata, Jacques, Pukuta, Elisabeth, Caviness, Katie, Bartlett, Maggie L, Gonzalez, Jeanette, Minogue, Timothy, Sozhamannan, Shanmuga, Gross, Stephen M, Schroth, Gary P, Kuhn, Jens H, Donaldson, Eric F, Delaporte, Eric, Sanchez-Lockhart, Mariano, Peeters, Martine, Muyembe-Tamfum, Jean-Jacques, Alpha Sall, Amadou, Palacios, Gustavo, and Ahuka-Mundeke, Steve

Published
2019
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49. Medical countermeasures during the 2018 Ebola virus disease outbreak in the North Kivu and Ituri Provinces of the Democratic Republic of the Congo: a rapid genomic assessment

Author

Mbala-Kingebeni, Placide, Aziza, Amuri, Di Paola, Nicholas, Wiley, Michael R, Makiala-Mandanda, Sheila, Caviness, Katie, Pratt, Catherine B, Ladner, Jason T, Kugelman, Jeffrey R, Prieto, Karla, Chitty, Joseph A, Larson, Peter A, Beitzel, Brett, Ayouba, Ahidjo, Vidal, Nicole, Karhemere, Stomy, Diop, Mamadou, Diagne, Moussa M, Faye, Martin, Faye, Ousmane, Aruna, Aaron, Nsio, Justus, Mulangu, Felix, Mukadi, Daniel, Mukadi, Patrick, Kombe, John, Mulumba, Anastasie, Villabona-Arenas, Christian-Julian, Pukuta, Elisabeth, Gonzalez, Jeanette, Bartlett, Maggie L, Sozhamannan, Shanmuga, Gross, Stephen M, Schroth, Gary P, Tim, Roger, Zhao, Junhua J, Kuhn, Jens H, Diallo, Boubacar, Yao, Michel, Fall, Ibrahima S, Ndjoloko, Bathe, Mossoko, Mathias, Lacroix, Audrey, Delaporte, Eric, Sanchez-Lockhart, Mariano, Sall, Amadou A, Muyembe-Tamfum, Jean-Jacques, Peeters, Martine, Palacios, Gustavo, and Ahuka-Mundeke, Steve

Published
2019
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