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Luminal distensibility measurement has demonstrated relevance to various disease processes, though its effects on clinical decision-making have been less well understood. This study aims to characterize the clinical impact of impedance planimetry measurement as well as the learning curve associated with its use in the esophagus. A single provider performed distensibility measurement in conjunction with upper endoscopy for a variety of clinical indications with the functional lumen imaging probe (FLIP) over a period of 21 months. Procedural data were prospectively collected and, along with medical records, retrospectively reviewed. Seventy-three procedures (70 patients) underwent esophageal distensibilitymeasurement over the timeline of this study. The most common procedural indications were known or suspected achalasia (32.9%), dysphagia with connective tissue disease (13.7%), eosinophilic esophagitis (12.3%), and dysphagia with prior fundoplication (9.6%). FLIP results independently led to a change in management in 29 (39.7%) cases and supported a change in management in an additional 15 (20.5%) cases. The most common change in management was a new or amended therapeutic procedure (79.5%). Procedural time added by distensibility measurement was greater among earlier cases than among later cases. The median time added overall was 5 minutes and 46 seconds. Procedural time added varied significantly by procedural indication, but changes in management did not. Distensibility measurement added meaningful diagnostic information that impacted therapeutic decision-making in the majority of cases in which it was performed. Procedural time added by this modality is typically modest and decreases with experience. [ABSTRACT FROM AUTHOR]

Introduction: We undertook this study to compare the analgesic efficacy of 0.1% bupivacaine and 0.1% ropivacaine with fentanyl using patient controlled epidural analgesia. Materials and methods: 60 parturients of ⩾ 36 weeks of gestation with cephalic presentation in spontaneous labour with cervical dilatation ⩽ 5cms and baseline pain score of ⩽ 30 on visual analogue scale (VAS), were enrolled in the study. Group I received 10 ml bolus of 0.1% bupivacaine with fentanyl 2μg/ml while Group II received 10 ml bolus of 0.1% ropivacaine with fentanyl 2μg/ml followed by patient controlled epidural analgesia (PCEA) using PCA pump. The primary outcome measured was analgesic efficacy using VAS. Results: VAS scores during first and second hour were found to be significantly lower in Group 1 as compared to Group 2 (Figure 1) with a significant difference from their respective baselines. Group II showed a statistically higher total drug consumption and number of boluses used (62.33 ± 26.6 vs 48.47 ± 16.7 and1.40 ± 0.8 vs 2.00 ± 0.8 respectively) as compared to group I (Table 2) (Figure 3). The motor block showed a statistically significant difference at 4th, 5th and 6th hours between the two groups (Figure 4). Conclusion: The present study demonstrated that 0.1% ropivacaine or 0.1% bupivacaine with fentanyl 2μg/ml used during labour analgesia by PCEA were equally effective for controlling the labour pain with more total drug consumption and less motor blockade associated with 0.1% ropivacaine as compared to 0.1% bupivacaine. [ABSTRACT FROM AUTHOR]

Although the relationship between antipsychotic medication, particularly second-generation antipsychotics (SGAs), and metabolic disturbance is increasingly accepted, there is an important, but little recognised, potential interaction between this and the other important serious adverse effect of neuroleptic malignant syndrome (NMS). We report a case of a 35- year old female who developed new onset type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure following treatment with a SGA for a first manic episode. The history is strongly suggestive of concurrent NMS. This case raises important questions about non-ketotic, hyperosmolar diabetic coma with antipsychotics, the possible association between hyperglycaemia and hyperthermia, and the direction of causality in this, the recognition of either syndrome when they co-exist and management issues in such patients. These questions are considered in the context of currently available literature. [ABSTRACT FROM AUTHOR]

Properties of wavelets with finite as well as infinite support are summarised to facilitate mother wavelet selection in a chosen application. The quantitative guidelines will reduce dependence on trial-and-error schemes resorted to for selection and underscore the importance of such selection in any application of interest. In wavelet-based image sequence superresolution, studied during the last four years, use of a B-spline mother wavelet is justified. [ABSTRACT FROM AUTHOR]

Antilipidemic drugs are routinely detected in effluent and surface waters downstream of wastewater treatment plants. A mixture exposure study with nine environmentally relevant antilipidemic drugs was performed with zebrafish (Danio rerio , ZF) and fathead minnow (Pimephales promelas , FHM) embryos to investigate the effects on sensitive embryologic stages. Zebrafish embryos were exposed nominally to: (a) 0.005 μM, (b) 0.05 μM, or (c) 0.5 μM of each drug in the mixture. Fathead minnow embryos were exposed nominally to: (a) 0.0005 μM, (b) 0.005 μM, or (c) 0.05 μM of each drug in the mixture. Several of the individual drug concentrations were within ranges previously found in the environment. Multiple metrics demonstrate that (a) exposure of ZF and FHM embryos to antilipidemic drugs during embryonic development results in lethal and sublethal effects, (b) ZF were more sensitive than FHM based on median lethal concentration (LC 50 0.02 μM and 0.05 μM, respectively), but FHM exhibited more severe abnormal sublethal morphologies than zebrafish embryos, and (c) the sublethal effects differed between the two species. This model identified novel specific endpoints for assessing sensitive, sublethal effects of pharmaceuticals in the environment. Abnormal myofiber birefringence pattern, hemorrhage, and heart rate are not included in standard evaluations but each of these metrics demonstrated a dose-dependent response in this study. Results demonstrate risk to fish development with potential repercussions at the population level, especially if environmental concentrations increase. • Antilipidemic exposure caused lethal and sublethal effects in fish embryos. • Zebrafish embryos had lower median lethal concentration than fathead minnow embryos. • Fathead minnow embryos exhibit more severe abnormal morphologies than zebrafish. • Sublethal effects differed between the two species. • Antilipidemics may pose a significant threat to aquatic wildlife inhabiting contaminated ecosystems. [ABSTRACT FROM AUTHOR]

Aims: To audit benzodiazepine prescribing in a Community Mental Health team, with a view to identifying areas for improvement. Methods: All the 245 patient''s case notes were audited, from October 2004 to October 2005, of those in the Outpatients Clinic''s case load, in North Shields. A semi structured pro-forma was designed. On the basis of the guidelines from Committee on Safety of Medicines (CSM) (1988), DOH Document (1999), DOH Ireland report of benzodiazepine commission (2002), www.benzo.org.uk, Newcastle, North Tyneside and Northumbria NHS Trust Guidelines for hypnotic/anxiolytic use and Lanarkshire PCT guidelines, the standards were finalised. The audit tool looked at demographics, indications of benzodiazepine prescription, co-morbid medical conditions, substance misuse, psychotherapeutic intervention and follow up of patients prescribed benzodiazepines. Results: 245 notes were audited. 24% of all patients were on benzodiazepines. Out of those, 56% were women. A third of these patients were between 41-50 year olds, while another third were older than 50years. Co-morbid substance and alcohol dependence was uncommon. The most common diagnoses in these patients were mood disorder (31%), schizophrenia (20%), and personality disorders (12%). Nearly two-third of patients suffered from co-morbid medical conditions. 25% patients had had psychological therapies. None of them were given advice about sleep hygiene and driving. Conclusions: Older women with mood disorders are more likely to be prescribed benzodiazepines longer than recommended. Advice about driving, sleep hygiene, information about side effects and risks was not offered to most patients. Recommendations have been made, with a view to re-auditing and improving services. [Copyright &y& Elsevier]

Background Esophagogastric junction ( EGJ) outflow obstruction ( EGJOO) is characterized by impaired EGJ relaxation with intact or weak peristalsis. Our aims were to evaluate: (i) prevalence, (ii) yield of fluoroscopy, endoscopy, and endoscopic ultrasound ( EUS), (iii) outcomes, and (iv) whether this data differed based on quantitative EGJ relaxation. Methods Studies that met criteria for EGJOO were identified. Demographics, encounters, endoscopy, radiology, treatment decisions, and outcomes were extracted. Key Results Sixty studies were identified. Dysphagia was the most common symptom. Forty patients underwent barium esophagram ( BE): normal (11), hiatal hernia (20), spasm/dysmotility (17), EGJ narrowing (10), compression (2), Schatzki's ring (5), malrotation (1), gastric volvulus (1), mass (1). Esophagogastroduodenoscopy ( EGD) was performed in 41 patients: normal (19), hiatal hernia (13), Schatzki's ring (6), esophagitis (3), esophageal candidiasis (3), mass (1). EUS was performed in 20 patients and was frequently normal. Twenty-two patients underwent intervention. While transient improvement was noted in the majority, persistent improvement was seen in only one of nine patients (dilatation), four of six patients (botulinum toxin), and three patients who underwent per-oral endoscopic myotomy. No patients treated with medical therapy alone had improvement in dysphagia. There was no difference in symptoms or outcomes based on quantitative EGJ relaxation. Conclusions & Inferences The manometric criterion EGJOO defines a heterogeneous clinical group. While BE, EGD, and EUS all provide complementary information, a significant percentage of these studies will be normal. For patients with dysphagia, outcome may depend on EGJ disruption. There were no differences in symptoms our outcomes based on quantitative EGJ relaxation. [ABSTRACT FROM AUTHOR]

Review of the literature regarding prognostic value of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients showed CIMP to be associated with worse disease-free survival and overall survival. Future research into CIMP's most appropriate operational definition and its action mechanism would be of vital importance in helping us put past study results into proper perspective.Background Divergent findings regarding the prognostic value of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) patients exist in current literature. We aim to review data from published studies in order to examine the association between CIMP and CRC prognosis. Materials and methods A comprehensive search for studies reporting disease-free survival (DFS), overall survival (OS), or cancer-specific mortality of CRC patients stratified by CIMP is carried out. Study findings are summarized descriptively and quantitatively, using adjusted hazard ratios (HRs) as summary statistics. Results Thirty-three studies reporting survival in 10 635 patients are included for review. Nineteen studies provide data suitable for meta-analysis. The definition of CIMP regarding gene panel, marker threshold, and laboratory method varies across studies. Pooled analysis shows that CIMP is significantly associated with shorter DFS (pooled HR estimate 1.45; 95% confidence interval (CI) 1.07–1.97, Q = 3.95, I2 = 0%) and OS (pooled HR estimate 1.43; 95% CI 1.18–1.73, Q = 4.03, I2 = 0%) among CRC patients irrespective of microsatellite instability (MSI) status. Subgroup analysis of microsatellite stable (MSS) CRC patients also shows significant association between shorter OS (pooled HR estimate 1.37; 95% CI 1.12–1.68, Q = 4.45, I2 = 33%) and CIMP. Seven studies have explored CIMP's value as a predictive factor on stage II and III CRC patient's DFS after receiving adjuvant 5-fluorouracil (5-FU) therapy: of these, four studies showed that adjuvant chemotherapy conferred a DFS benefit among CIMP(+) patients, one concluded to the contrary, and two found no significant correlation. Insufficient data was present for statistical synthesis of CIMP's predictive value among CRC patients receiving adjuvant 5-FU therapy. Conclusion CIMP is independently associated with significantly worse prognosis in CRC patients. However, CIMP's value as a predictive factor in assessing whether adjuvant 5-FU therapy will confer additional survival benefit to CRC patients remained to be determined through future prospective randomized studies. [ABSTRACT FROM AUTHOR]

Abstracts from various medical journals are presented. "Endolymphatic Sac Surgery for Ménière's Disease: Long-term Results After Primary and Revision Surgery," from "Archives of Otolaryngology - Head and Neck Surgery" is presented. "Familial Predisposition for Psychiatric Disorder: Comparison of Subjects Treated for Cannabis-Induced Psychosis and Schizophrenia," from "Archives of General Psychiatry" is presented. "The Impact of a Vision Screening Law on Older Driver Fatality Rates," from "Archives of Opthalmology" is presented.