17 results on '"Ahola-Olli, Ari V."'
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2. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
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Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, and Kleineidam, Luca
- Abstract
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
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- 2019
3. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
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Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, and Kleineidam, Luca
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Humans ,Neurodegenerative Diseases ,Genetic Predisposition to Disease ,Cognition ,Reaction Time ,Mental Disorders ,Multifactorial Inheritance ,Polymorphism ,Single Nucleotide ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Young Adult ,Genetic Loci ,Neurodevelopmental Disorders ,Prevention ,Behavioral and Social Science ,Mental Health ,Neurosciences ,Biotechnology ,Genetics ,Human Genome ,Neurological ,Mental health - Abstract
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P
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- 2018
4. Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts
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Ahola-Olli, Ari V., Mustelin, Linda, Kalimeri, Maria, Kettunen, Johannes, Jokelainen, Jari, Auvinen, Juha, Puukka, Katri, Havulinna, Aki S., Lehtimäki, Terho, Kähönen, Mika, Juonala, Markus, Keinänen-Kiukaanniemi, Sirkka, Salomaa, Veikko, Perola, Markus, Järvelin, Marjo-Riitta, Ala-Korpela, Mika, Raitakari, Olli, and Würtz, Peter
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- 2019
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5. Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder
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Häkkinen, Katja, primary, Kiander, Wilma, additional, Kidron, Heidi, additional, Lähteenvuo, Markku, additional, Urpa, Lea, additional, Lintunen, Jonne, additional, Vellonen, Kati-Sisko, additional, Auriola, Seppo, additional, Holm, Minna, additional, Lahdensuo, Kaisla, additional, Kampman, Olli, additional, Isometsä, Erkki, additional, Kieseppä, Tuula, additional, Lönnqvist, Jouko, additional, Suvisaari, Jaana, additional, Hietala, Jarmo, additional, Tiihonen, Jari, additional, Palotie, Aarno, additional, Ahola-Olli, Ari V., additional, and Niemi, Mikko, additional
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- 2023
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6. Functional characterization of six SLCO1B1 (OATP1B1) variants observed in Finnish individuals with a psychotic disorder
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Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., Niemi, Mikko, Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., and Niemi, Mikko
- Abstract
Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adverse drug effects with statin treatment. We explored the effect of six rare SLCO1B1 single nucleotide variants (SNVs) occurring in Finnish individuals with a psychotic disorder on expression and functionality of the OATP1B1 protein. The SUPER-Finland study has performed exome sequencing on 9381 individuals with at least one psychotic episode during their lifetime. SLCO1B1 SNVs were annotated with PHRED-scaled combined annotation-dependent (CADD) scores and the Ensembl variant effect predictor. In vitro functionality studies were conducted for the SNVs with a PHRED-scaled CADD score of >10 and predicted to be missense. To estimate possible changes in transport activity caused by the variants, transport of 2′,7′-dichlorofluorescein (DCF) in OATP1B1-expressing HEK293 cells was measured. According to the findings, additional tests with rosuvastatin and estrone sulfate were conducted. The amount of OATP1B1 in crude membrane fractions was quantified using a liquid chromatography tandem mass spectrometry-based quantitative targeted absolute proteomics analysis. Six rare missense variants of SLCO1B1 were identified in the study population, located in transmembrane helix 3: c.317T>C (p.106I>T), intracellular loop 2: c.629G>T (p.210G>V), c.633A>G (p.211I>M), c.639T>A (p.213N>L), transmembrane helix 6: 820A>G (p.274I>V), and the C-terminal end: 2005A>C (p.669N>H). Of these variants, SLCO1B1 c.629G>T (p.210G>V) resulted in the loss of in vitro function, abolishing the uptake of DCF, estrone sulfate, and rosuvastatin and reducing the membrane protein expression to 31% of reference OATP1B1. Of the six rare missense variants, SLCO1B1 c.629G>T (p.210G>V) causes a loss of function of OATP1
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- 2023
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7. Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children
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Ahola-Olli, Ari V, Pitkänen, Niina, Kettunen, Johannes, Oikonen, Mervi K, Mikkilä, Vera, Lehtimäki, Terho, Kähönen, Mika, Pahkala, Katja, Niinikoski, Harri, Kangas, Antti J, Soininen, Pasi, Ala-Korpela, Mika, Viikari, Jorma S, Rönnemaa, Tapani, Simell, Olli, and Raitakari, Olli T
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- 2014
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8. Functional Characterization of Six SLCO1B1(OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder
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Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., and Niemi, Mikko
- Abstract
Variants in the SLCO1B1(solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adverse drug effects with statin treatment. We explored the effect of six rare SLCO1B1single nucleotide variants (SNVs) occurring in Finnish individuals with a psychotic disorder on expression and functionality of the OATP1B1 protein. The SUPER-Finland study has performed exome sequencing on 9381 individuals with at least one psychotic episode during their lifetime. SLCO1B1SNVs were annotated with PHRED-scaled combined annotation-dependent (CADD) scores and the Ensembl variant effect predictor. In vitro functionality studies were conducted for the SNVs with a PHRED-scaled CADD score of >10 and predicted to be missense. To estimate possible changes in transport activity caused by the variants, transport of 2′,7′-dichlorofluorescein (DCF) in OATP1B1-expressing HEK293 cells was measured. According to the findings, additional tests with rosuvastatin and estrone sulfate were conducted. The amount of OATP1B1 in crude membrane fractions was quantified using a liquid chromatography tandem mass spectrometry-based quantitative targeted absolute proteomics analysis. Six rare missense variants of SLCO1B1were identified in the study population, located in transmembrane helix 3: c.317T>C (p.106I>T), intracellular loop 2: c.629G>T (p.210G>V), c.633A>G (p.211I>M), c.639T>A (p.213N>L), transmembrane helix 6: 820A>G (p.274I>V), and the C-terminal end: 2005A>C (p.669N>H). Of these variants, SLCO1B1c.629G>T (p.210G>V) resulted in the loss of in vitro function, abolishing the uptake of DCF, estrone sulfate, and rosuvastatin and reducing the membrane protein expression to 31% of reference OATP1B1. Of the six rare missense variants, SLCO1B1c.629G>T (p.210G>V) causes a loss of function of OATP1B1 transport in vitro and severely decreases membrane protein abundance. Carriers of SLCO1B1c.629G>T might be susceptible to altered pharmacokinetics of OATP1B1 substrate drugs and might have increased likelihood of adverse drug effects such as statin-associated musculoskeletal symptoms.
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- 2023
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9. The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease
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Kalaoja, Marita, primary, Corbin, Laura J., additional, Tan, Vanessa Y., additional, Ahola‐Olli, Ari V., additional, Havulinna, Aki S., additional, Santalahti, Kristiina, additional, Pitkänen, Niina, additional, Lehtimäki, Terho, additional, Lyytikäinen, Leo‐Pekka, additional, Raitoharju, Emma, additional, Seppälä, Ilkka, additional, Kähönen, Mika, additional, Ripatti, Samuli, additional, Palotie, Aarno, additional, Perola, Markus, additional, Viikari, Jorma S., additional, Jalkanen, Sirpa, additional, Maksimow, Mikael, additional, Salomaa, Veikko, additional, Salmi, Marko, additional, Raitakari, Olli T., additional, Kettunen, Johannes, additional, and Timpson, Nicholas J., additional
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- 2021
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10. Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy
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Nath, Artika P., primary, Ritchie, Scott C., additional, Grinberg, Nastasiya F., additional, Tang, Howard Ho-Fung, additional, Huang, Qin Qin, additional, Teo, Shu Mei, additional, Ahola-Olli, Ari V., additional, Würtz, Peter, additional, Havulinna, Aki S., additional, Santalahti, Kristiina, additional, Pitkänen, Niina, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Lyytikäinen, Leo-Pekka, additional, Raitoharju, Emma, additional, Seppälä, Ilkka, additional, Sarin, Antti-Pekka, additional, Ripatti, Samuli, additional, Palotie, Aarno, additional, Perola, Markus, additional, Viikari, Jorma S., additional, Jalkanen, Sirpa, additional, Maksimow, Mikael, additional, Salmi, Marko, additional, Wallace, Chris, additional, Raitakari, Olli T., additional, Salomaa, Veikko, additional, Abraham, Gad, additional, Kettunen, Johannes, additional, and Inouye, Michael, additional
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- 2019
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11. Implementation of CYP2D6copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder
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Häkkinen, Katja, Kiiski, Johanna I., Lähteenvuo, Markku, Jukuri, Tuomas, Suokas, Kimmo, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Lahdensuo, Kaisla, Kajanne, Risto, Kaunisto, Mari A., Tuulio-Henriksson, Annamari, Kampman, Olli, Hietala, Jarmo, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Paunio, Tiina, Suvisaari, Jaana, Kalso, Eija, Niemi, Mikko, Tiihonen, Jari, Daly, Mark, Palotie, Aarno, and Ahola-Olli, Ari V.
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We demonstrate that CYP2D6copy-number variation (CNV) can be imputed using existing imputation algorithms. Additionally, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genetically bottle-necked population of Finland. We combined GWAS chip and CYP2D6CNV data from the Breast Cancer Pain Genetics study to construct an imputation panel (n= 902) for CYP2D6CNV. The resulting data set was used as a CYP2D6CNV imputation panel in 9262 non-related individuals from the SUPER-Finland study. Based on imputation of 9262 individuals we confirm the higher frequency of CYP2D6 ultrarapid metabolizers and a 22-fold enrichment of the UGT1A1decreased function variant rs4148323 (UGT1A1*6) in Finland compared with non-Finnish Europeans. Similarly, the NUDT15variant rs116855232 was highly enriched in Finland. We demonstrate that imputation of CYP2D6CNV is possible and the methodology enables studying CYP2D6in large biobanks with genome-wide data.
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- 2022
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12. Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts
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Ahola-Olli, Ari V., primary, Mustelin, Linda, additional, Kalimeri, Maria, additional, Kettunen, Johannes, additional, Jokelainen, Jari, additional, Auvinen, Juha, additional, Puukka, Katri, additional, Havulinna, Aki S., additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Juonala, Markus, additional, Keinänen-Kiukaanniemi, Sirkka, additional, Salomaa, Veikko, additional, Perola, Markus, additional, Järvelin, Marjo-Riitta, additional, Ala-Korpela, Mika, additional, Raitakari, Olli, additional, and Würtz, Peter, additional
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- 2019
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13. Circulating Metabolites and the Risk of Type 2 Diabetes—A Prospective Study of 10,938 Young Adults from Four Finnish Cohorts
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AHOLA-OLLI, ARI V., primary, MUSTELIN, LINDA, additional, KALIMERI, MARIA, additional, KETTUNEN, JOHANNES, additional, JOKELAINEN, JARI J., additional, AUVINEN, JUHA, additional, PUUKKA, KATRI S., additional, HAVULINNA, AKI S., additional, LEHTIMÄKI, TERHO, additional, KÄHÖNEN, MIKA, additional, SALOMAA, VEIKKO, additional, PEROLA, MARKUS, additional, JARVELIN, MARJO-RIITTA, additional, ALA-KORPELA, MIKA, additional, and WURTZ, PETER, additional
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- 2018
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14. Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
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Davies, Gail, primary, Lam, Max, additional, Harris, Sarah E, additional, Trampush, Joey W, additional, Luciano, Michelle, additional, Hill, W David, additional, Hagenaars, Saskia P, additional, Ritchie, Stuart J, additional, Marioni, Riccardo E, additional, Fawns-Ritchie, Chloe, additional, Liewald, David CM, additional, Okely, Judith A, additional, Ahola-Olli, Ari V, additional, Barnes, Catriona LK, additional, Bertram, Lars, additional, Bis, Joshua C, additional, Burdick, Katherine E, additional, Christoforou, Andrea, additional, DeRosse, Pamela, additional, Djurovic, Srdjan, additional, Espeseth, Thomas, additional, Giakoumaki, Stella, additional, Giddaluru, Sudheer, additional, Gustavson, Daniel E, additional, Hayward, Caroline, additional, Hofer, Edith, additional, Ikram, M Arfan, additional, Karlsson, Robert, additional, Knowles, Emma, additional, Lahti, Jari, additional, Leber, Markus, additional, Li, Shuo, additional, Mather, Karen A, additional, Melle, Ingrid, additional, Morris, Derek, additional, Oldmeadow, Christopher, additional, Palviainen, Teemu, additional, Payton, Antony, additional, Pazoki, Raha, additional, Petrovic, Katja, additional, Reynolds, Chandra A, additional, Sargurupremraj, Muralidharan, additional, Scholz, Markus, additional, Smith, Jennifer A, additional, Smith, Albert V, additional, Terzikhan, Natalie, additional, Thalamuthu, Anbu, additional, Trompet, Stella, additional, Lee, Sven J van der, additional, Ware, Erin B, additional, Windham, B Gwen, additional, Wright, Margaret J, additional, Yang, Jingyun, additional, Yu, Jin, additional, Ames, David, additional, Amin, Najaf, additional, Amouyel, Philippe, additional, Andreassen, Ole A, additional, Armstrong, Nicola J, additional, Assareh, Amelia A, additional, Attia, John R, additional, Attix, Deborah, additional, Avramopoulos, Dimitrios, additional, Bennett, David A, additional, Böhmer, Anne C, additional, Boyle, Patricia A, additional, Brodaty, Henry, additional, Campbell, Harry, additional, Cannon, Tyrone D, additional, Cirulli, Elizabeth T, additional, Congdon, Eliza, additional, Conley, Emily Drabant, additional, Corley, Janie, additional, Cox, Simon R, additional, Dale, Anders M, additional, Dehghan, Abbas, additional, Dick, Danielle, additional, Dickinson, Dwight, additional, Eriksson, Johan G, additional, Evangelou, Evangelos, additional, Faul, Jessica D, additional, Ford, Ian, additional, Freimer, Nelson A, additional, Gao, He, additional, Giegling, Ina, additional, Gillespie, Nathan A, additional, Gordon, Scott D, additional, Gottesman, Rebecca F, additional, Griswold, Michael E, additional, Gudnason, Vilmundur, additional, Harris, Tamara B, additional, Hartmann, Annette M, additional, Hatzimanolis, Alex, additional, Heiss, Gerardo, additional, Holliday, Elizabeth G, additional, Joshi, Peter K, additional, Kähönen, Mika, additional, Kardia, Sharon LR, additional, Karlsson, Ida, additional, Kleineidam, Luca, additional, Knopman, David S, additional, Kochan, Nicole A, additional, Konte, Bettina, additional, Kwok, John B, additional, Hellard, Stephanie Le, additional, Lee, Teresa, additional, Lehtimäki, Terho, additional, Li, Shu-Chen, additional, Liu, Tian, additional, Koini, Marisa, additional, London, Edythe, additional, Longstreth, Will T, additional, Lopez, Oscar L, additional, Loukola, Anu, additional, Luck, Tobias, additional, Lundervold, Astri J, additional, Lundquist, Anders, additional, Lyytikäinen, Leo-Pekka, additional, Martin, Nicholas G, additional, Montgomery, Grant W, additional, Murray, Alison D, additional, Need, Anna C, additional, Noordam, Raymond, additional, Nyberg, Lars, additional, Ollier, William, additional, Papenberg, Goran, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Poldrack, Russell A, additional, Psaty, Bruce M, additional, Reppermund, Simone, additional, Riedel-Heller, Steffi G, additional, Rose, Richard J, additional, Rotter, Jerome I, additional, Roussos, Panos, additional, Rovio, Suvi P, additional, Saba, Yasaman, additional, Sabb, Fred W, additional, Sachdev, Perminder S, additional, Satizabal, Claudia, additional, Schmid, Matthias, additional, Scott, Rodney J, additional, Scult, Matthew A, additional, Simino, Jeannette, additional, Slagboom, P Eline, additional, Smyrnis, Nikolaos, additional, Soumaré, Aïcha, additional, Stefanis, Nikos C, additional, Stott, David J, additional, Straub, Richard E, additional, Sundet, Kjetil, additional, Taylor, Adele M, additional, Taylor, Kent D, additional, Tzoulaki, Ioanna, additional, Tzourio, Christophe, additional, Uitterlinden, André, additional, Vitart, Veronique, additional, Voineskos, Aristotle N, additional, Kaprio, Jaakko, additional, Wagner, Michael, additional, Wagner, Holger, additional, Weinhold, Leonie, additional, Wen, K Hoyan, additional, Widen, Elisabeth, additional, Yang, Qiong, additional, Zhao, Wei, additional, Adams, Hieab HH, additional, Arking, Dan E, additional, Bilder, Robert M, additional, Bitsios, Panos, additional, Boerwinkle, Eric, additional, Chiba-Falek, Ornit, additional, Corvin, Aiden, additional, Jager, Philip L De, additional, Debette, Stéphanie, additional, Donohoe, Gary, additional, Elliott, Paul, additional, Fitzpatrick, Annette L, additional, Gill, Michael, additional, Glahn, David C, additional, Hägg, Sara, additional, Hansell, Narelle K, additional, Hariri, Ahmad R, additional, Ikram, M Kamran, additional, Jukema, J. Wouter, additional, Vuoksimaa, Eero, additional, Keller, Matthew C, additional, Kremen, William S, additional, Launer, Lenore, additional, Lindenberger, Ulman, additional, Palotie, Aarno, additional, Pedersen, Nancy L, additional, Pendleton, Neil, additional, Porteous, David J, additional, Räikkönen, Katri, additional, Raitakari, Olli T, additional, Ramirez, Alfredo, additional, Reinvang, Ivar, additional, Rudan, Igor, additional, Rujescu, Dan, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Schofield, Peter W, additional, Schofield, Peter R, additional, Starr, John M, additional, Steen, Vidar M, additional, Trollor, Julian N, additional, Turner, Steven T, additional, Duijn, Cornelia M Van, additional, Villringer, Arno, additional, Weinberger, Daniel R, additional, Weir, David R, additional, Wilson, James F, additional, Malhotra, Anil, additional, McIntosh, Andrew M, additional, Gale, Catharine R, additional, Seshadri, Sudha, additional, Mosley, Thomas H., additional, Bressler, Jan, additional, Lencz, Todd, additional, and Deary, Ian J, additional
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- 2017
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15. Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors
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Ahola-Olli, Ari V., primary, Würtz, Peter, additional, Havulinna, Aki S., additional, Aalto, Kristiina, additional, Pitkänen, Niina, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Lyytikäinen, Leo-Pekka, additional, Raitoharju, Emma, additional, Seppälä, Ilkka, additional, Sarin, Antti-Pekka, additional, Ripatti, Samuli, additional, Palotie, Aarne, additional, Perola, Markus, additional, Viikari, Jorma S., additional, Jalkanen, Sirpa, additional, Maksimow, Mikael, additional, Salomaa, Veikko, additional, Salmi, Marko, additional, Kettunen, Johannes, additional, and Raitakari, Olli T., additional
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- 2017
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16. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
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Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, Van Der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Knopman, David S, Kochan, Nicole A, Konte, Bettina, Kwok, John B, Le Hellard, Stephanie, Lee, Teresa, Lehtimäki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T, Lopez, Oscar L, Loukola, Anu, Luck, Tobias, Lundervold, Astri J, Lundquist, Anders, Lyytikäinen, Leo-Pekka, Martin, Nicholas G, Montgomery, Grant W, Murray, Alison D, Need, Anna C, Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A, Psaty, Bruce M, Reppermund, Simone, Riedel-Heller, Steffi G, Rose, Richard J, Rotter, Jerome I, Roussos, Panos, Rovio, Suvi P, Saba, Yasaman, Sabb, Fred W, Sachdev, Perminder S, Satizabal, Claudia L, Schmid, Matthias, Scott, Rodney J, Scult, Matthew A, Simino, Jeannette, Slagboom, P Eline, Smyrnis, Nikolaos, Soumaré, Aïcha, Stefanis, Nikos C, Stott, David J, Straub, Richard E, Sundet, Kjetil, Taylor, Adele M, Taylor, Kent D, Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, André, Vitart, Veronique, Voineskos, Aristotle N, Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab HH, Arking, Dan E, Bilder, Robert M, Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L, Debette, Stéphanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L, Gill, Michael, Glahn, David C, Hägg, Sara, Hansell, Narelle K, Hariri, Ahmad R, Ikram, M Kamran, Jukema, J Wouter, Vuoksimaa, Eero, Keller, Matthew C, Kremen, William S, Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L, Pendleton, Neil, Porteous, David J, Räikkönen, Katri, Raitakari, Olli T, Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W, Schofield, Peter R, Starr, John M, Steen, Vidar M, Trollor, Julian N, Turner, Steven T, Van Duijn, Cornelia M, Villringer, Arno, Weinberger, Daniel R, Weir, David R, Wilson, James F, Malhotra, Anil, McIntosh, Andrew M, Gale, Catharine R, Seshadri, Sudha, Mosley, Thomas H, Bressler, Jan, Lencz, Todd, and Deary, Ian J
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quantitative trait ,cognitive neuroscience ,genetics of the nervous system ,genome-wide association studies ,3. Good health - Abstract
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
17. Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy
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Nath, Artika P, Ritchie, Scott C, Grinberg, Nastasiya F, Tang, Howard Ho-Fung, Huang, Qin Qin, Teo, Shu Mei, Ahola-Olli, Ari V, Würtz, Peter, Havulinna, Aki S, Santalahti, Kristiina, Pitkänen, Niina, Lehtimäki, Terho, Kähönen, Mika, Lyytikäinen, Leo-Pekka, Raitoharju, Emma, Seppälä, Ilkka, Sarin, Antti-Pekka, Ripatti, Samuli, Palotie, Aarno, Perola, Markus, Viikari, Jorma S, Jalkanen, Sirpa, Maksimow, Mikael, Salmi, Marko, Wallace, Chris, Raitakari, Olli T, Salomaa, Veikko, Abraham, Gad, Kettunen, Johannes, and Inouye, Michael
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Adult ,Male ,Adolescent ,Quantitative Trait Loci ,Polymorphism, Single Nucleotide ,protein QTLs ,colocalisation analysis ,Young Adult ,GWAS ,Humans ,Gene Regulatory Networks ,Genetic Predisposition to Disease ,Longitudinal Studies ,Prospective Studies ,Child ,metabolites ,Aged ,Genome, Human ,eQTLs ,1. No poverty ,Genetic Pleiotropy ,Blood Proteins ,Middle Aged ,Prognosis ,cytokines ,3. Good health ,blood cell traits ,multivariate analysis ,Cardiovascular Diseases ,Female ,cardiometabolic diseases ,Biomarkers ,Follow-Up Studies ,Genome-Wide Association Study - Abstract
Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease states. Despite increasing evidence that cytokines operate in concert, many of the physiological interactions between cytokines, and the shared genetic architecture that underlies them, remain unknown. Here, we aimed to identify and characterize genetic variants with pleiotropic effects on cytokines. Using three population-based cohorts (n = 9,263), we performed multivariate genome-wide association studies (GWAS) for a correlation network of 11 circulating cytokines, then combined our results in meta-analysis. We identified a total of eight loci significantly associated with the cytokine network, of which two (PDGFRB and ABO) had not been detected previously. In addition, conditional analyses revealed a further four secondary signals at three known cytokine loci. Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summary statistics with the cytokine network associations revealed shared causal variants between the eight cytokine loci and other traits; in particular, cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins, on metabolic traits such as lipoprotein and lipid levels, on blood-cell-related traits such as platelet count, and on disease traits such as coronary artery disease and type 2 diabetes.
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