63 results on '"Ahmet Koçak"'
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2. Türkiye Spor Toto Süper Lig’de Yer Alan Futbol Kulüplerinin Twitter Kullanım Pratiklerinin İncelenmesi
- Author
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Ahmet Koçak and Atacan Şimşek
- Subjects
sosyal medya ,twitter ,futbol kulüpleri ,Social sciences (General) ,H1-99 - Abstract
Türkiye Spor Toto Süper Lig’de yer alan futbol kulüplerinin Twitter kullanım pratiklerinin analiz edilmesini amaçlayan bu çalışmada 1 Ocak- 28 Şubat 2022 tarihleri arasında Süper Lig’de yer alan ve Twitter’da en fazla takipçisi olan Beşiktaş JK, Fenerbahçe SK ve Galatasaray SK’nin Twitter’daki yazılı paylaşımları ile görsel kullanım şekilleri değerlendirmeye tabi tutulmuştur. Araştırma sürecinde toplam 1409 tweetin analizi içerik analizi yöntemine göre analiz edilmiştir. Çalışmanın zaman aralığında resmi hesaplardan yapılan gönderilerin hepsi incelenerek öncelikle kodlama kılavuzu oluşturulmuş ve veriler Microsoft Excel programına işlenmiştir. Daha sonra veriler, SPSS (Statistical Package for the Social Sciences) programına aktarılarak veri analizi gerçekleştirilmiştir. Çalışmada araştırmaya konu olan Beşiktaş JK, Fenerbahçe SK ve Galatasaray SK’nin Twitter’ı geleneksel medya kullanımına benzer şekilde sadece ileti göndermek için kullandığı ve takipçileri olan taraftarlarıyla etkileşime girmekten kaçındıkları sonuçlarına ulaşılmıştır. Ayrıca kulüplerin Twitter’ın alıntılama, etiketleme, hashtag gibi çift yönlü etkileşimi sağlayan özelliklerini kullanmada pek de başarılı olamadıkları görülürken, Twitter’ı tek yönlü bir ilan panosu gibi kullanmaları kullanıcılar ve kulüpler arasındaki etkileşim olayını zayıflattığı ortaya çıkmıştır.
- Published
- 2022
- Full Text
- View/download PDF
3. Diphallus: A Rare Urological Anomaly - What to Do Next? Case Report and Literature Review
- Author
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Halil İbrahim İvelik, İbrahim Güven Kartal, Ahmet Koçak, Oğuzhan Yusuf Sönmez, and Bekir Aras
- Published
- 2023
4. Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines
- Author
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Ayşen IŞIK, Kezban UÇAR ÇİFÇİ, Hayrani Eren BOSTANCI, Yusuf TUTAR, Ahmet KOÇAK, and Mustafa YILMAZ
- Subjects
Chemistry, Multidisciplinary ,Calix[4]arene ,Anticancer activity ,Schiff Base ,General Medicine ,Kimya, Ortak Disiplinler - Abstract
In this study, four stages were used to create brand-new p-tert-butyl-calix [4] arene Schiff base derivatives. First, p-tert-butyl-phenol and formaldehyde are reacted to create p-tert-butyl-calix [4] arene (1). In the following step, methyl bromoacetate and p-ter-butyl-calix [4] arene (1) were combined with acetone and reflux to create the p-tert-butyl-calix [4] arene diester complex (2). The third step involves reacting the diester compound (2) and hydrazine hydrate to create the p-tert-butyl-calix [4] arene hydrazinamide molecule (3). In the final stage, calix [4] arene Schiff base derivatives (4a-d) were produced in good yields by combining compound (3), p-tert-butyl-calix [4] arene hydrazinamide, and various aldehyde derivatives with reflux in EtOH. Through the use of 1H-NMR, 13C-NMR, infrared spectroscopy, and elemental analysis, the structures of produced compounds were verified. Four distinct cancer lines are linked to the antitumor activity of synthetic chemicals. (HT-29, a human colon cancer cell line, PC-3, a human prostate cancer cell line, C6, a rat glioma cell line and MCF-7, a human breast cancer cell line). Weak antitumor activity was seen in synthetic substances. However, only compound 4b was found to have potential efficacy against C6 and HT-29. It is clear that compound 4b, which has a nitro substitute on the phenyl ring, draws attention due to its increased activity.
- Published
- 2022
5. Detection of Misuse or Illegal Use of Medicines: A Study Example for Tacrolimus Active Ingredient
- Author
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Ahmet KOÇAK and Hüseyin Erkin SÜLEKLİ
- Abstract
Corruption and irregularity are situations that we may encounter in every field such as banking, insurance, security and health. Health expenditures are increasing every year all around the world. The amount of corruption and irregularity is parallel to this increase. Corruption and irregularities in the health sector both threaten human health and cause financial losses. With methods for detecting corruption and irregularities, malpractices can be avoided and also financial losses can be prevented, thus contributing to the improvement of health service delivery. Our aim in the study is to detect corruption and irregularities about drugs, which constitute an important part of health expenditures. Drugs with the Anatomical Therapeutic Chemical (ATC) code with the same active ingredient were examined. Anomaly detection, association analysis and rule-based data mining methods were used for the detection of corruption and irregularity. 24 physicians were identified as with high risk. Those who found to be at risk in the analysis was examined specifically and it was confirmed that all of them abused the drug with the relevant active ingredient, thus it means that the method used is 100% consistent and accurate.
- Published
- 2022
6. Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
- Author
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Ayşen IŞIK, Ulviye Acar Çevik, Ismail Çelik, Hayrani Eren Bostancı, Arzu Karayel, Gülsüm Gündoğdu, Ufuk Ince, Ahmet Koçak, Yusuf Özkay, Zafer Asım Kaplancıklı, and Eczacılık Fakültesi
- Subjects
Inorganic Chemistry ,Organic Chemistry ,Benzimidazole Anticancer Antimicrobial Antioxidant DFT ADMET PXRD ,Spectroscopy ,Analytical Chemistry - Abstract
Based on the biologically active heterocycle compounds, a series of new benzimidazole-hydrazone deriva- tives ( 3a-3j ) were synthesized, starting from 4-(6-chloro-1 H -benzimidazol-2-yl) benzohydrazide. The syn- thesized compounds were characterized by 1 H NMR, 13 C NMR, and HRMS spectroscopic methods. The synthesized compounds were preliminarily evaluated for their in vitro antimicrobial, anticancer and an- tioxidant activity. The antimicrobial activity was checked against S. aureus ATCC 29213, E. coli ATCC 25922, and C. albicans ATCC 10231 by micro-dilution method. The findings exhibited that the compounds pos- sessed moderate antimicrobial potential. The compounds were also checked for their in vitro anticancer activities against HT-29 (colorectal cancer cell line) using the MTT assay. It was observed that all the compounds 3a-3j showed weak antiproliferative activity against HT-29 cells. The compounds were also analyzed for their antioxidant capacity by Tas & Tos activity. The compound 3d showed a high anti- oxidative effect with 30.81 μmol H O 2 2 Equiv./L value. The lowest energy state of compound 3d was real- ized in DMSO medium by using the B3LYP method at 6–311G (d,p) level, the optimized geometry of it is about 0.50 and 17 kcal/ mol more stable than in other solvents and the gas phase, respectively. The lower E = 3.563 eV indicates the higher reactivity of compound 3d , this is compatible with biological experi- mental data and shows high antioxidant property of the compound. In silico ADMET studies of compound 3d were performed. Indexing of the X-ray powder diffraction pattern was performed for compound 3a .
- Published
- 2022
7. Sağlıkta veri kalitesi ve veri madenciliği uygulamaları
- Author
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Ahmet KOÇAK and Prof.dr. Mehmet Ali ERGÜN
- Abstract
Veri günümüzde çok sık karşılaşılan bir terimdir. Verinin doğru kullanımı doğru değerlendirmeyi sağlar. Bu da kaynakların verimli kullanımını, verilen hizmetin kalitesinin artmasını sağlamaktadır. Verinin en çok toplandığı alanların başında sağlık sektörü gelmektedir. Sağlık hizmet sunumunun maddi ve manevi yükü ağırdır. Bu hizmetin en iyi şekilde verilmesi, kaynakların doğru kullanılması ile yakın ilişkilidir. Sağlık verilerinden anlamlı sonuçların çıkarılarak hekimlere, hemşirelere ve sağlık yöneticileri gibi sağlık sektörü çalışanlarına yön gösterecek bilgilerin sağlanması sağlık verilerinin büyüklüğü düşünüldüğünde ancak veri madenciliği metotları ile mümkündür. Sağlık sektörünün insan hayatını direkt etkileyen bir doğası olması sebebi ile sağlıkta kullanılan verilerin kalitesinin en üst düzeyde olması beklenmektedir. Bu çalışmada veri kalitesini ve veri madenciliğini bütüncül olarak ele almıştır. Uygulama örnekleri aracılığıyla veri madenciliği ile sağlık sektöründe ne tür çalışmalar yapılabileceğine dair genel bir bakış açısı sağlanmıştır.
- Published
- 2022
8. Synthesis, characterization, molecular docking, dynamics simulations, and in silico absorption, distribution, metabolism, and excretion (ADME) studies of new thiazolylhydrazone derivatives as butyrylcholinesterase inhibitors
- Author
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Ayşen Işık, Ulviye Acar Çevik, Ismail Celik, Tuğba Erçetin, Ahmet Koçak, Yusuf Özkay, and Zafer Asım Kaplancıklı
- Subjects
General Biochemistry, Genetics and Molecular Biology - Abstract
In this study, two novel series of thiazolylhydrazone derivatives containing 4-ethylpiperazine (3a–3f) and 4-methoxyphenylpiperazine (3g–3l) side chains were synthesized and their structures were characterized by spectral (1H NMR, 13C NMR, and MS spectra) analyses. In vitro inhibitory activities of synthesized compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were determined by Ellman method. According to the results, all compounds showed a weak inhibitory effect on AChE, while promising results were obtained on BChE. Among the synthesized compounds, the activities of the derivatives carrying 4-ethylpiperazine (3a–3f) structure were found to be more effective than the compounds carrying 4-methoxyphenyl piperazine (3g–3l) derivatives. Especially, compound 3f bearing the nitro substituent was found to be the most promising compound on BChE in the series. The absorption, distribution, metabolism, and excretion (ADME) parameters of the synthesized compounds were predicted by using the SwissADME server. The potential binding mode and stability of compound 3f with BChE were investigated by the molecular docking and dynamics simulations. The results showed that 3f was strongly bound up with BChE with the optimal conformation; in addition, their binding free energy reached −167.936 ± 13.109 kJ/mol.
- Published
- 2022
9. Dilemma of modern human being in the story Yoksulluk İçimizde ve Bu Böyledir of Mustafa Kutlu
- Author
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Ahmet Koçak
- Subjects
Mustafa Kutlu,hikâye,Bu Böyledir,Yoksulluk İçimizde,modernizm ,Mustafa Kutlu,hikâye,Bu Böyledir,Yoksulluk İçimizde,modernization ,Linguistics ,General Medicine ,Dil Bilim - Abstract
Türk edebiyatının seksenli yıllardan itibaren hem konu hem şekil hem de tür anlamında büyük bir değişim ve gelişim gösterdiği, sayısal olarak zenginleştiği bilinen bir gerçektir. İnsanlar arasında gelir düzeyinde görülen farklılıkların derinleşmesi, ülke dışına daha çok açılma ve teknolojik gelişmeler insanın teknik donanımlara ulaşmasını kolaylaştırmış, bu da beraberinde alışagelmiş bir hayat tarzının dışına çıkmaya, yeni bir ifadeyle modernleşme yolunda yeni açılımların sağlanmasına imkân tanımıştır. Moderniteye karşı duyulan özlem, teknik imkânlar sayesinde dış dünya insanının (burada kastedilen daha çok Batı insanıdır) yaşantısına ve kavuştuğu imkânlara ulaşma arzu ve çabası ülke insanında da tesirini göstermiştir. Edebî metinler bu anlamıyla özelde bireyi genelde ise toplumu yansıtan en iyi eserlerdir. Anadolu ve büyük şehir hayatını deneyimlemiş ve ikisini metinlerine çok iyi yansıtmış isimlerden birisi de Mustafa Kutlu’dur. Son yarım asrın en önemli yazarlarından biri olan Mustafa Kutlu, 1970’li yıllarda başladığı hikâye yazma serüvenini günümüze kadar zenginleştirerek devam ettirmiş nadir yazarlardandır. Kutlu’nun bu hikâye yazma serüveni neredeyse yılda bir kitap yayımlayarak devam edegelmiştir. Ayrıca Deneme ve inceleme türünde de eserler kaleme alan yazarın daha çok hikâyeye sadık kalması bile Kutlu’yu Türk edebiyatında ayrı bir yere koymaya kâfidir. Yoksulluk İçimizde ve Bu Böyledir onun bu düşüncelerini en iyi yansıttığı eserler arasında sayılabilir. Bu makalede, bu iki öykü kitabından hareketle modern insanın açmazları üzerine bir inceleme yapılacaktır., Mustafa Kutlu is one of the prominent figures who is well known for his precious stories in the field of Turkish storytelling and who has brought a breath of fresh air to that kind of works. M. Kutlu began to write stories in 1970s and has continued his efforts to collect them into a book. He has recently followed in the tradition to produce a piece of work at least a year. Regarding his being a storyteller, he is a productive writer. What make his works distinctive is that he has a different viewpoint of social, cultural and moral issues and that he puts them into words in a flowing style. The power of his stories can be seen in his effective use of the language that charms and impresses the reader and his authentic narration. Generally he gets his feet on the ground with respect to the issues he tells in his stories. That is the cultural historical heritage of these lands. Although in his works modern human beings use the latest facilities of science and technology and lead a much better life compared to the past, it is possible to observe they come to a deadlock without any alternatives. Among his works Yoksulluk İçimizde ve Bu Böyledir can be considered as the ones in which he reflects these thoughts best. In this article, an analysis will be conducted on the dilemmas of modern human beings based on these two story books.
- Published
- 2021
10. ADVERGAME NEDİR VE NE DEĞİLDİR? ADVERGAME’İ ANLAMAK İÇİN DAVRANIŞSAL TEORİLERİN YENİDEN ÖZETLENMESİ
- Author
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Murat Aktan and Ahmet Koçak
- Subjects
Applied Mathematics - Abstract
Owing to the latest technological advancements, alternative ads based on digital technology have been increasing exponentially compared to traditional ads such as TV and newspaper ads. Advergaming utilizing online video games was recently becoming popular as a new form of advertisement. Although the marketing and communication industries make more use of advergaming every day and despite being a growing marketing platform, there is a lack of research in the marketing literature that examines the underpinning behavioural theories for advergaming implications. Accordingly, this article aims to identify fundamental consumer behaviour theories such as Social Cognitive Theory, Limited Capacity Model, Elaboration Likelihood Model etc. to understand whether advergames can positively influence players toward a particular brand. This study suggests that eight major theories from the consumer behaviour field are relevant to elaborate players' behaviour in advergames as well as providing a holistic understanding of this new media.
- Published
- 2020
11. AZERBAYCAN TÜRKÇESİYLE YAZILMIŞ İLK 'LEYLÂ VÜ MECNÛN' MESNEVİSİNİN DİL ÖZELLİKLERİ
- Author
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Ahmet Koçak
- Published
- 2020
12. The Effect of Türkiye's Country Image and General Product Image on Domestic Car TOGG's Perceived Product Image and Purchase Intention
- Author
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İlay TİLKİ, Bilgehan BOZKURT, Murat AKTAN, and Ahmet KOÇAK
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Social ,Economics ,Pharmacology (medical) ,Genel Ürün İmajı ,Ülke İmajı ,Algılanan Ürün İmajı ,Satın Alma Niyeti ,Yerli Otomobil ,TOGG ,Sosyal ,İktisat ,General product image ,country image ,perceived product image ,purchase intention ,domestic car ,indigenous automobile - Abstract
Uluslararası pazarlama literatüründe, ürünlerin algılanan imajlarının tüketicilerin algıladıkları ülke imajı ve genel ürün imajından etkilendiği konusunda bir uzlaşı söz konusudur. Türkiye’nin Otomobili Girişim Grubu’nun TOGG markasıyla üreteceği yerli otomobillerin iki modeli, oldukça rekabetçi olan otomotiv piyasasına, 2024 yılına kadar arz edilecektir. Buradan yola çıkan bu araştırma, TOGG markasının algılanan ürün imajını ve satın alma niyetini, Türkiye’nin genel ürün ve ülke imajı kapsamında incelemektedir. 368 kişiden toplanan veri ve uygulanan Yapısal Eşitlik Modeli (YEM) ile, Türkiye’nin ülke imajı ile genel ürün imajının TOGG’un algılanan ürün imajına etkisi olduğu ortaya konulmuştur. Bunun yanı sıra, TOGG’un algılanan imajının da satın alma niyeti üzerine anlamlı ve pozitif bir etkisi olduğu gözlenmiştir. Bu çalışma, gelişmekte olan bir ülkenin ülke-ürün imajını araştırması, yerli elektrikli bir otomobil satın alma davranışı ile bütünsel olarak ele alması ve genel ürün imajı ile ülke imajını Türkiye özelinde ikincil düzey bir faktör olarak ölçmesi ile pazarlama literatürüne önemli bir katkıda bulunmaktadır. Araştırma bulguları ile ayrıca, otomotiv sektörüne çeşitli önerilerde bulunulmaktadır., There is a consensus in the international marketing literature that the perceived images of products are influenced by the country image and general product image perceived by consumers. The domestic automobile brand, named TOGG by Türkiye's Automobile Initiative Group, will launch SUV and Sedan models in the highly competitive automotive market by 2024. To that end, this research examined the perceived product image and purchase intention of the TOGG brand within the scope of Türkiye's overall product and country image. With the data obtained from 368 people and the applied Structural Equation Model (SEM), it has been revealed that Türkiye's country image and general product image have an effect on TOGG's perceived product image. In addition, it has been observed that the perceived image of TOGG has a significant and positive effect on purchase intention. This study makes an important contribution to the marketing literature as a result of examining the country-product image of a developing country, considering it holistically with the buying behaviour of a domestic electric car, and measuring the general product image and country image as a secondary factor in Turkey. With the research findings, various suggestions are also presented to the automotive industry.
- Published
- 2022
13. Pancar Şekeri Üretiminde Organik Asitlerin Giderilmesi ve Renk İyileştirmesi
- Author
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Ali DELİKANLI, Münevver SÖKMEN, and Ahmet KOÇAK
- Subjects
Agricultural, Engineering ,Psychiatry and Mental health ,Mühendislik, Ziraat ,Beet sugar,Organic acid,Color enhancement ,Pancar şekeri,Organik Asit,Renk İyileştirilmesi - Abstract
Organic acids are one of the important factors preventing the crystallization of sucrose, together with the formation of invert sugar as a result of the decomposition of sucrose and affecting the pH of the syrup in factories producing sugar from beet. In this study, it is aimed to improve the color problem, which is an important quality factor, by adsorption process using activated carbon and modified pumice stone during the dark syrup stage of the crystal sugar production refinery. After the syrup samples are taken from the Konya Sugar Factory 2020/2021 campaign production line at certain times, the amounts of acetic acid, propionic acid and butyric acid are determined. Acid amounts have been determined quantitatively by HPLC device. Also, syrup colors have been compared using pH and ICUMSA methods before and after adsorption., Pancardan şeker üretimi yapan fabrikalarda şerbet pH’ına etki edip, sakkarozun parçalanması sonucu invert şeker oluşumuyla birlikte, sakkarozun kristallenmesini engelleyen önemli faktörlerden biri organik asitlerdir. Bu çalışmada, kristal şeker üretim rafinerisi koyu şerbet aşamasında aktif karbon ve modifiye pomza taşı kullanılarak adsorbsiyon işlemiyle önemli bir kalite faktörü olan renk sorununun iyileştirilmesi amaçlanmıştır. Konya Şeker Fabrikası 2020/2021 kampanya dönemi üretim hattından belirli zamanlarda şerbet numuneleri alındıktan sonra asetik asit, propiyonik asit ve bütirik asit miktarları belirlenmiştir. Asit miktarları HPLC cihazı ile nicel olarak tayin edilmiştir. Ayrıca, adsorpsiyon öncesinde ve sonrasında pH ve ICUMSA metodları kullanılarak şerbet rengi karşılaştırması yapılmıştır.
- Published
- 2022
14. Türkiye Spor Toto Süper Lig’de Yer Alan Futbol Kulüplerinin Twitter Kullanım Pratiklerinin İncelenmesi
- Author
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Atacan ŞİMŞEK, Ahmet KOÇAK, and Başka Kurum
- Subjects
Social ,Twitter ,Futbol Kulüpleri ,Football Clubs ,Sosyal ,Social Media ,Sosyal Medya - Abstract
Türkiye Spor Toto Süper Lig’de yer alan futbol kulüplerinin Twitter kullanım pratiklerinin analiz edilmesini amaçlayan bu çalışmada 1 Ocak- 28 Şubat 2022 tarihleri arasında Süper Lig’de yer alan ve Twitter’da en fazla takipçisi olan Beşiktaş JK, Fenerbahçe SK ve Galatasaray SK’nin Twitter’daki yazılı paylaşımları ile görsel kullanım şekilleri değerlendirmeye tabi tutulmuştur. Araştırma sürecinde toplam 1409 tweetin analizi içerik analizi yöntemine göre analiz edilmiştir. Çalışmanın zaman aralığında resmi hesaplardan yapılan gönderilerin hepsi incelenerek öncelikle kodlama kılavuzu oluşturulmuş ve veriler Microsoft Excel programına işlenmiştir. Daha sonra veriler, SPSS (Statistical Package for the Social Sciences) programına aktarılarak veri analizi gerçekleştirilmiştir. Çalışmada araştırmaya konu olan Beşiktaş JK, Fenerbahçe SK ve Galatasaray SK’nin Twitter’ı geleneksel medya kullanımına benzer şekilde sadece ileti göndermek için kullandığı ve takipçileri olan taraftarlarıyla etkileşime girmekten kaçındıkları sonuçlarına ulaşılmıştır. Ayrıca kulüplerin Twitter’ın alıntılama, etiketleme, hashtag gibi çift yönlü etkileşimi sağlayan özelliklerini kullanmada pek de başarılı olamadıkları görülürken, Twitter’ı tek yönlü bir ilan panosu gibi kullanmaları kullanıcılar ve kulüpler arasındaki etkileşim olayını zayıflattığı ortaya çıkmıştır., The aim of this study is to analyze the Twitter using practices of football clubs in the Turkish Spor Toto Super League. Between January 1st and February 28th, 2022, Beşiktaş JK, Fenerbahçe SK and Galatasaray SK, who took part in the Super League and had the highest number of followers on Twitter, evaluated their written and visual posts on Twitter. For research 1409 tweets was analyzed according to the content analysis method. The data was first processed into the Microsoft Excel program with the coding guide and then the data were transferred to the SPSS (Statistical Package for the Social Sciences) program and data analysis was done. In the study, it was concluded that Beşiktaş JK, Fenerbahçe SK and Galatasaray SK only use Twitter to send messages, similar to traditional media usage, and avoid interacting with their fans. In addition, it has been seen that clubs are not successful in using Twitter's features that provide two-way interaction such as quoting, tagging and hashtags. The use of Twitter as a one-way bulletin board has weakened the interaction between users and team.
- Published
- 2022
15. Büyük Ruhun Romanını Yazan Adam: Mehmet Akif Ersoy ve İstiklal Marşının Kültürel Kaynakları
- Author
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Ahmet KOÇAK
- Published
- 2021
16. Synthesis, characterization, molecular docking, dynamics simulations, and
- Author
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Ayşen, Işık, Ulviye Acar, Çevik, Ismail, Celik, Tuğba, Erçetin, Ahmet, Koçak, Yusuf, Özkay, and Zafer Asım, Kaplancıklı
- Subjects
Molecular Docking Simulation ,Structure-Activity Relationship ,Molecular Structure ,Butyrylcholinesterase ,Acetylcholinesterase ,Cholinesterase Inhibitors - Abstract
In this study, two novel series of thiazolylhydrazone derivatives containing 4-ethylpiperazine (
- Published
- 2021
17. Yeni Tiyazolil-Hidrazin Türevlerinin Sentezi ve Asetilkolinesteraz (AChE) ve Bütirilkolinesteraz (BuChE) Aktivite Çalışmaları
- Author
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Ayşen IŞIK, Ulviye ACAR ÇEVİK, Tugba ERCETİN, and Ahmet KOÇAK
- Subjects
Basic Sciences ,Temel Bilimler ,Alzheimer Hastalığı,Tiyazolilhidrazin,Ellman Metot ,General Medicine ,Alzheimer,Thiazolylhydrazine,Ellman Method - Abstract
Alzheimer's disease (AD) has been associated with ecreased cognitive function, memory loss, and dementia due to the death of brain cells over time. Existence of limiting practices in the treatment of AD, and the fact that the disease ranks third in health expenditures in the world after cancer and heart diseases, directs researchers to early diagnosis and new treatment methods on AD. Today, it is thought that there is a direct relationship between cholinergic abnormalities and AD. Studies have shown that acetylcholine (ACh) level increases due to acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition can improve cognitive impairment in the initial stages of Alzheimer's disease. The best method to increase these ACh levels is to suppress the AChE or BuChE enzymes that break down ACh. Therefore, in this study, substituted thiazolylhydrazine derivatives were designed, synthesized and their cholinesterase inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes against AD were investigated. The structures of the target compounds were illuminated by 1H NMR/13C NMR analysis methods. The effects of the target compounds on the on AChE and BuChE enzymes were evaluated using the Ellman process and as a result of the enzyme inhibiton studies of the target compounds, it was determined that the 3d compound showed moderate butyrylcholinesterase activity., Alzheimer hastalığı (AH), zamanla beyin hücrelerinin ölümüne bağlı olarak bilişsel işlevlerde azalma, hafıza kaybı ve bunama ile ilişkilendirilmiştir. Alzheimer hastalığının tedavisinde sınırlayıcı uygulamaların mevcut oluşu, hastalığın sağlık harcamalarında kanser ve kalp hastalıklardan sonra dünyada üçüncü sırada oluşu araştırmacıları AH üzerinde erken evrede tanıma ve yeni tedavi yöntemlerine yönlendirmektedir. Günümüzde kolinerjik anomalikler ile AH arasında doğrudan bir ilişki olduğu düşünülmektedir. Çalışmalar, asetilkolinesteraz (AChE) ve bütirilkolinesteraz (BuChE) inhibisyonunun asetilkolin (ACh) seviyesinde meydana gelen artışların Alzheimer hastalığının başlangıç evrelerindeki bilişsel yetmezliği iyileştirebileceğini kanıtlamıştır. Dolayısıyla ACh düzeylerini arttırmak için uygulanacak en iyi metot ise, ACh’yi yıkan AChE veya BuChE enzimlerinin baskılanmasıdır. Dolayısıyla yapılan bu çalışmada, sübstitüe edilmiş tiyazolilhidrazin türevleri tasarlanmış, sentezlenmiş ve AH’ ye karşı asetilkolinesteraz (AChE) ve bütirilkolinesteraz (BuChE) kolinesteraz enzimlerinin inhibisyon potansiyelleri araştırılmıştır. Hedef bileşiklerin yapıları 1H NMR/13C NMR analiz yöntemleri ile aydınlatılmıştır. Hedef bileşiklerin AChE ve BuChE enzimleri üzerindeki inhibisyon etkileri Ellman yöntemiile değerlendirilmiş ve hedef bileşiklerin enzim inhibisyon çalışmaları sonucunda 3d bileşiğinin orta düzeyde bütirilkolinesteraz enzimini inhibe ettiği tespit edilmiştir.
- Published
- 2021
18. Comparison of the Characteristics of Patients Undergoing Elective and Emergency Surgery for Crohn’s Disease: A Single-Center Retrospective Cohort Study
- Author
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Hilmi Bozkurt, Sena Çağla Özden, Hogir Aslan, Adnan Hut, Muzaffer Akıncı, Fazilet Erözgen, Ahmet Kocakuşak, and Doğan Yıldırım
- Subjects
crohn’s disease ,surgery ,early complication ,Specialties of internal medicine ,RC581-951 - Abstract
Aim: Most patients with Crohn’s disease (CD) have a lifetime threat of emergency or elective surgery. These patients tend to have a high risk of postoperative complications. This study aims to compare the preoperative and operative characteristics and postoperative complications of patients who underwent emergency and elective surgery for CD. Method: Patients with CD aged ≥18 years who underwent emergency and scheduled surgery between January 2016 and April 2021 in a single-center general surgery clinic were included in this study. The patients’ demographic characteristics, comorbidities, drugs used, indications for surgery, preoperative laboratory findings, surgery type, anastomosis method, blood transfusion, infection parameters, surgical procedures, need for a postoperative intensive care unit, length of hospital stay, early postoperative complications, need for reoperation, and early surgical mortality were evaluated retrospectively from the hospital files. Results: The study included 25 patients within the date range determined retrospectively. There were 18 (72%) men and 7 (28%) women, and the mean age was 37.7±12.5 years. Eleven (44%) patients were operated on under emergency conditions, and 14 (56%) patients were surgically treated under elective circumstances. An ostomy was performed in 5 (20%) of the emergency surgery patients. Conclusion: Postoperative serious complications (Clavien-Dindo grade ≥3) still occur at high rates in patients operated on for CD. Ostomy indication and a longer hospital stay are more common in patients undergoing emergency surgery.
- Published
- 2024
- Full Text
- View/download PDF
19. MARKA MENŞEİ TANIMA DOĞRULUĞU KAVRAMI VE MISIR PAZARINDAKI TÜRK MARKALARI ÜZERİNE BİR ARAŞTIRMA
- Author
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Ahmet Koçak and Azra Bayraktar
- Subjects
Turkish ,Brand awareness ,media_common.quotation_subject ,Marka orijini,ülke menşei,Türk markaları,Mısır pazarı ,Advertising ,language.human_language ,Country of origin ,Management ,İşletme ,Perception ,language ,Business ,Brand origin,country-of-origin,Turkish brands,Egypt market ,media_common - Abstract
Yüksek katma değerli ve markalı ürünlerin ihracatı, ülkelerin ekonomileri için hayati öneme sahiptir. Markaların, yer aldıkları pazarlardaki bilinirliklerini ve menşei algılarını ölçmek, mikro düzeyde işletmelerin, makro düzeyde ise dünyanın ülke markasına dair algılarının yönetilebilmesi için, büyük önem taşımaktadır. Marka literatüründe ve pazarlama uygulamalarındaki yeri ve öneminden ötürü Marka Menşei kavramı araştırılmış; Mısır'da yaşayan 840 Mısırlı tüketiciye, ülkede faaliyet gösteren 12 Türk, 5 global markanın menşei testi yapılmıştır. Orijini en yüksek oranda doğru bilinen ilk 3 marka, Türk markaları olmuştur., Exports of high value-added and branded products and services are vital for the economies of all countries. Measuring brand awareness and the perception of brand origin in the markets where brands operate is of great importance to both countries and enterprises to flourish perceived country brand. The concept of Brand Origin, an essential part of the branding literature and marketing practices, has been tested. 840 Egyptian consumers were asked about the origin of twelve Turkish and five global brands. Turkish brands are listed as the first three brands whose origin is accurately known to the highest.
- Published
- 2019
20. Extensive time in narrow spaces: The prison in Sabahattin Ali’s narratives (stories)
- Author
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Ahmet Koçak
- Subjects
Politics ,State (polity) ,Poetry ,Aesthetics ,media_common.quotation_subject ,Natural (music) ,Narrative ,Prison ,General Medicine ,Space (commercial competition) ,Turkish literature ,media_common - Abstract
Bütün varlıkların üzerinde yaşadığı yer olarak tanımlanan mekân, insan için de çok şey ifade etmektedir. Çünkü insanoğlu var olandan beri bir mekân üzerinde yaşamakta ve ona şekil verme uğraşı içinde bulunmaktadır. Başlangıçtan bugüne kadar coğrafya, doğal ve tarihsel olaylar, siyasi ve ekonomik sebepler, bilimdeki gelişmeler, yeni icatlar ve teknolojik gelişmeler insanoğlunun mekânla ilişkisinde zamanla değişikliklere sebep olsa da insan - mekân ilişkisini değiştirememiştir. Michel Facoult’un “Başka Mekânlara Dair” adlı kuramsal eserinde de işaret ettiği gibi Ortaçağda, Rönesans’ta ve sonrasında modern dönemde mekân anlayışı farklıdır. Hatta buna post-modern dönemi de eklemek gerekir. Modern Türk edebiyatının önemli simalarından Sabahattin Ali’nin genelde anlatılarında özelde ise öykülerinde, mekânın kapalı - dar ve açık-geniş şekilde kullandığı görülür. Mahpushane devlet otoritesi ile inşa edilmiş kapalı - dar mekânlardır. Sabahattin Ali şu ya da bu sebeple hapse düşmüş ve bu mekânları deneyimleyerek yaşamış birisidir. Bu makalede roman, öykü, şiir gibi farklı türlerde eserler vermiş Türk edebiyatının önemli isimlerinden Sabahattin Ali’nin öykülerinde genelde mekân, özelde ise hapishane konusunun nasıl işlendiği, yazarın bir şekilde kaldığı bu mekânların eserlerine nasıl yansıdığı örneklerle açıklamaya çalışılacaktır.
- Published
- 2019
21. Yayın İlkelerir
- Author
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Ahmet Koçak
- Published
- 2019
22. Editörden
- Author
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Ahmet KOÇAK
- Published
- 2019
23. Göç Zamanı’na Hazırlanmak: Bahaeddin Özkişi’nin Öykülerinde Dinî/Metafizik Görünüm
- Author
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Ahmet Koçak
- Subjects
Göç Zamanı,Bahaeddin Özkişi,din/metafizik,öykü ,General Medicine ,Göç Zamanı,Bahaeddin Özkişi,metaphysics/religion,short story - Abstract
Expressed in dictionaries by referring todifferent concepts such as departure, transition, flight, moving and transfer;the term migration [göç] is definedas “the act of leaving one location for another, individually or socially;moving or migrating from one country to another for economic, social andpolitical reasons”. Apart from these meanings, the term in Turkish came torefer to “the act of migrating from this world to the afterlife, passing away,death” starting from the 16th century onwards. This meaning wasquite often used in classical as well as modern Turkish poetry, and is perhapsbest exemplified with the koşma(free-form folk poem) by Bayburtlu Zihni, one of the outstanding figures ofTurkish folk poetry: “I came to see that he moved his feet away from his abode”(Vardım ki yurdundan ayak göçürmüş).Beside poetic works, this theme has also been extensively treated by modernliterary genres such as novels and stories. It sometimes gave its name tonovels or stories, or at times featured as an element or event within the plot.Bahaeddin Özkişi is indeed one of the important figures of Turkish literaturewho failed to receive rightful attention, and fell (or was maybe deliberatelyconsigned) into oblivion. He deserves a special place in Turkish literature notonly with his novels but also short stories. Hence, this article attempts toanalyze the stories in his work GöçZamanı [Time for Migration] from a religious/mystic/metaphysicalperspective., Sözlüklerde rihlet, intikal, hicret, taşınma,nakil gibi farklı kavramlarla ifade edilen göç, “Ekonomik, toplumsal, siyasisebeplerle bireylerin veya toplulukların bir ülkeden başka bir ülkeye, biryerleşim yerinden başka bir yerleşim yerine gitme işi, taşınma, hicret,muhaceret” şeklinde tanımlanır. Bu anlamlarının dışında 16. yüzyıldan itibarenTürkçede “Dünyadan âhirete göçme, ölme, vefat”anlamlarında dakullanılmaya başlanmıştır göç. Bu anlamıyla da gerek Klasik, gerekse ModernTürk şiirinde pek çok yerde kullanılmıştır. Hatta halk şiirinin önde gelenisimlerinden Bayburtlu Zihni’nin “Vardım ki yurdundan ayak göçürmüş” mısraıylabaşlayan koşması bu anlamıyla en yaygın bilinen şiirlerden birisidir. Manzumeserlerin dışında roman, hikâye gibi modern dönemin ürünü olan türlerde de bukonu geniş olarak işlenmiştir. Bazen roman ya da hikâyenin adı olmuş, bazen dekurgunun içinde konu, unsur olarak yer almıştır. Türk edebiyatında uzun yıllarhak ettiği yeri alamamış, unutulmuş/unutturulmuş isimlerden birisi de BahaeddinÖzkişi’dir. O sadece romanlarıyla değil, yazdığı öykülerle de Türk edebiyatındaayrı bir yerdedir. Bu makale çerçevesinde onun Göç Zamanı adlı eserinde yer alan öyküleri dinî/mistik/metafizikaçıdan değerlendirilmeye çalışılacaktır. 
- Published
- 2018
24. Impact of Smoking on the Ocular Surface, Tear Function, and Tear Osmolarity
- Author
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Hacı Murat Sağdık, Hatice Aktaş, Serdar Aktas, Ahmet Koçak, Mehmet Tetikoğlu, Metin Kocacan, and Fatih Özcura
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Cell Count ,Fluorophotometry ,Young Adult ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Cigarette smoking ,Surveys and Questionnaires ,Ophthalmology ,Humans ,Medicine ,tear osmolarity ,Dry eye disease ,Prospective Studies ,business.industry ,Osmolar Concentration ,Smoking ,Middle Aged ,Tear osmolarity ,eye diseases ,Sensory Systems ,Schirmer 1 test ,Case-Control Studies ,Tears ,Eyelid Diseases ,030221 ophthalmology & optometry ,Dry Eye Syndromes ,Female ,Goblet Cells ,sense organs ,business ,Ocular surface ,030217 neurology & neurosurgery - Abstract
Purpose: This study evaluated the effects of cigarette smoking on the ocular surface, tear function, and tear osmolarity. Materials and Methods: A total of 50 smokers with at least 5 years of heavy smoking (defined as 1 pack/day) and 51 nonsmoking, healthy individuals were enrolled. Tear osmolarity was measured with an osmometer (TearLab™ Osmolarity System). Ocular surface examinations involved corneal fluorescein staining, measurement of the tear film breakup time (TBUT), the Schirmer 1 test, measurement of corneal sensitivity with a Cochet–Bonnet esthesiometer, and conjunctival impression cytology. Dry eye symptoms were scored using the Ocular Surface Disease Index (OSDI) questionnaire. The results were compared with those from an age and sex-matched control group. The Chi-squared and independent sample t-tests were used for statistical analyses. Results: The smokers had significantly higher tear osmolarity values (305.38 ± 9.81 vs. 301.14 ± 7.04 mOsm/L; p = 0.014) and OSDI scores (34.13 ± 16.58 vs. 18.09 ± 9.61; p, Firat University Scientific Research Projects Management Unit, This study was supported by the Dumlupinar University Scientific Research Projects Commission (Project number: 2015–73).
- Published
- 2017
25. SENTIMENT AND OPINION MINING: RECENT ISSUES AND AN APPLICATION FOR THE THIRD AIRPORT
- Author
-
Emrah Bilgiç and Ahmet Koçak
- Subjects
Tarih ,Beşeri Bilimler ,Sosyal Çalışma ,Applied Mathematics ,Sosyoloji - Abstract
Öteden beri insanoğlunun karar verme süreçlerinde başkalarının görüş veyorumlarına başvurması değişmeyen bir durumdur. Bilgiye hızlıca erişimin akıllıtelefonlar, tabletler ve bilgisayarlarla yapıldığı günümüz Büyük Veri Çağı’ndaözellikle internet ortamlarında her konu hakkında görüşler, bilgiler ve yorumlarpaylaşılmaktadır. Bu bilgi, görüş ve yorumlardan hem kişisel hem kurumsal bazdafaydalı bilgiler çıkarsamak amacıyla kullanılan Metin Madenciliği son yıllarda ençok araştırılan konulardan biri haline geline gelmiştir. Metin Madenciliği zamanlaçeşitli alanlara ayrılmış ve Görüş madenciliği veya Duygu Analizi alanları ortayaçıkmıştır. Günümüzde insanlar sosyal medya araçlarını, blogları, forumları sadecebilgi ve düşünce paylaşmak için kullanmakla kalmayıp, internet üzerinden satın alıpkullandıkları ürün/hizmet ile alakalı bilgileri de bu ortamlar aracılığıyla değerlendirmektedir. Bu çalışma İstanbul’daki Atatürk ve Sabiha Gökçen havalimanlarınıkullanan yabancı müşterilerin bir internet sitesinde yaptıkları yorumları Görüşve Duygu Madenciliği ile analiz etmeyi ve İstanbul’da kurulmuş olan 3. Havalimanı işletmecileri için bir çıkarsama sunmayı amaçlamaktadır. Analizler sonucuinsanların kalabalıktan, pahalılıktan, kabalıktan, kayıp bavullardan, zorluklardanve uçuş rötarlarından şikAyet ettikleri anlaşılmaktadır. It is an unchanging situation that human being asks others’ opinions and comments during the process of decision making. In today’s Big Data Age, where thefast access to information is easily made with smartphones, tablets and computers;opinions, information and comments are shared on every topic, especially on theinternet. Text Mining which is used to extract useful information from views andcomments for both personal and institutional basis has become one of the most researched subjects in recent years. Text Mining has been divided into different areasover time, and the topics of Opinion Mining or Sentiment Analysis have emerged.Today, people not only use social media tools, blogs, forums to share informationand ideas but also use those platforms to evaluate the products/services whichthey purchased over the internet. This study aims to analyse comments of foreigncustomers who used airports of Atatürk and Sabiha Gökçen in Istanbul. OpinionMining and Sentiment Analysis will present an inference for the operator of the3rd Airport in Istanbul. As a result of the analysis, it is understood that peoplecomplain about the crowd, the expensive, the rude, the lost baggage, the difficultiesand the flight delays.
- Published
- 2019
26. Sezai Karakoç’un Fikrî Yazılarında Doğu ve Batı Medeniyeti Tasavvuru
- Author
-
Ahmet Koçak
- Subjects
General Medicine - Abstract
Inanc ve ahlâk nizami olarak bir milletin ve toplumun maddi ve manevi varligina ait ustun niteliklerini, degerlerini, fikir ve sanat hayatindaki calismalarini, ilim, teknik, sanayi alanlardaki gelismelerini ifade etmek uzere kullanilan medeniyet kavraminin kokeni Islâm dunyasinda hicrete kadar goturulebilir. Hicretle Yesrib sehrinin adi Medine seklinde degistirilmis ve burasi yeni bir sistemin, anlayisin merkezi olmustur. Daha sonraki yuzyillarda Ibn-i Haldun, Mukaddime 'sinde toplumlarin hayatini ifade ederken bu kavramdan bahseder. Bati’da ise on sekizinci yuzyilin ortalarinda kendi toplumlarinin teknik ve ekonomik anlamda gelismisligini ifade etmek uzere ilk defa Fransizca olarak “civilisation” kavrami kullanilir. Osmanli’da medeniyet kavrami ise, Bati’daki civilisation kavramina karsilik olarak ve Bati’nin teknik anlamda ustunlugunu ifade etmek uzere uretilir. Dolayisiyla Turk edebiyatinda on dokuzuncu yuzyilda en cok kullanilan kavramlardan birisi “medeniyet”tir. Bugune kadar bircok Turk fikir adami, aydini bu kavrami tanimlamaya calismis, onun uzerine fikir yurutmustur. Suphesiz bu buyuk dusunurlerden birisi de son yarim asra damgasini vuran, sair ve fikir insani Sezai Karakoc’tur. Karakoc’a gore medeniyet temelde tektir ve bu mesale ilk insandan bugune kadar elden ele tasinarak gelmistir. O, vahiy temelli bu anlayisin hepsine birden “Hakikat medeniyeti” adini verir. Karakoc, fikri yazilarinda “hakikat medeniyeti”, “Islâm medeniyeti” ya da “insanligin medeniyeti” gibi kavramlari ilk insandan baslayarak son peygambere kadar takip eden silsilede olusan medeniyeti ifade etmek uzere kullanir. Onun medeniyet anlayisi, genelde siniflandirildigi gibi Dogu-Bati medeniyeti seklinde ikiye ayirmak yerine, ucuncu bir kategori olarak Islâm medeniyetini ayri bir baslik altinda ele almasidir. Bu tasnifiyle onun medeniyet kavramina yukledigi anlam oldukca farkli ve yenidir. Sezai Karakoc, Bati medeniyetini de Eski Yunan medeniyetinden baslatarak bir butun olarak kabul eder. Eski Yunan’dan Roma’ya oradan Ronesans ve Reforma uzanan surecte Bati medeniyetinin gecirdigi evreleri farkli acilardan yorumlayan Karakoc, Bati medeniyeti uzerine yeni dikkatler sunar. Bati’nin ozellikle son iki yuzyilda medeniyet goruntusu altinda Asyaliyi, Afrikaliyi kisaca kendinden olmayani kendisine donusturme hedefinin altinda yatan nedenleri acikliga kavusturmaya calisir. Bu makale cercevesinde sair ve mutefekkir Sezai Karakoc’un fikri yazilarinda en cok uzerinde durdugu kavramlardan birisi olan, genelde “medeniyet” ozelde ise Dogu ve Bati medeniyetleri kavramlariyla ilgili dusunceler uzerinde durulmustur.
- Published
- 2016
27. The relationship between atherogenic index of plasma and major risk factors of cardiovascular disease in obese and non-obese individuals
- Author
-
Ahmet Koçak, Ruhuşen Kutlu, and Seher Sayin
- Subjects
medicine.medical_specialty ,Waist ,Triglyceride ,business.industry ,Insulin ,medicine.medical_treatment ,General Engineering ,Obesity,cardiovascular disease,atherogenic index of plasma,insulin resistance ,Disease ,medicine.disease ,Obesity ,chemistry.chemical_compound ,Insulin resistance ,Blood pressure ,chemistry ,Health Care Sciences and Services ,Internal medicine ,Epidemiology ,medicine ,Sağlık Bilimleri ve Hizmetleri ,business - Abstract
Objectives: Obesity is a health problem with gradually increasing prevalence and directly contribute to the development of cardiovascular disease (CVD). We aimed to investigate the relationship between atherogenic index of plasma (AIP) and major risk factors of CVD in obese and non-obese individuals. Methods: This analytical case-control study was carried out on 501 individuals. Obese patients were included in the case group and normal-overweight individuals were included in the control group. The groups were similar in terms of ages and gender. Detailed medical background of the participants was recorded and antropometric parameters were measured. High-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglyceride, fasting blood glucose (FBG) and insulin were measured. AIP risk categories were created according to published epidemiological data: AIP < 0.1 is associated with low risk, 0.1-0.24 with moderate risk, and > 0.24 with high risk. Results: There was a statistically significant relationship between obesity, male gender, older age, smoking, insulin resistance, high waist circumference, elevation of the blood pressure, FBG and high CVD risk (p < 0.005). CVD risk in males were 6.254 times more than in females [OR=6.254, 95% CI; (2.287-17.107)], CVD risk in obese was 3.436 times more than in none-obese and CVD risk in individuals with insulin resistance was 5.560-fold increase than individuals without insulin resistance [OR=5.560, 95% CI; (3.069-10.070)] (p < 0.001). Conclusions: Our findings showed that increasing in AIP is associated with obesity and other cardiovascular risk factors. Therefore, AIP can be used as a simple, economic and non invasive marker to identify for CVD risk.
- Published
- 2018
28. Effect of radioactive iodine therapy on carotid intima media thickness in patients with hyperthyroidism
- Author
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Mehmet Erdi Korkmaz, Ahmet Koçak, Bekir Şanal, Türkan Paşalı Kilit, Cuneyt Kahraman, Cüneyt Kucur, Emre Kaçar, İlknur Işık, and Fatma Ezgi Can
- Subjects
Male ,medicine.medical_specialty ,Carotid arteries ,030204 cardiovascular system & hematology ,Age and sex ,Carotid Intima-Media Thickness ,Hyperthyroidism ,Iodine Radioisotopes ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,cardiovascular diseases ,Intima media thickness (IMT) ,Patient group ,Radioactive iodine therapy (RAI) ,business.industry ,General Medicine ,COMMON CAROTID ARTERY BIFURCATION ,Middle Aged ,Atherosclerosis ,Intima-media thickness ,030220 oncology & carcinogenesis ,cardiovascular system ,Cardiology ,Female ,Radioactive iodine therapy ,Radioactive iodine ,business ,Nuclear medicine - Abstract
WOS: 000369319000011, PubMed: 26511018, Objective The aim of this study was to evaluate the carotid intima media thickness (IMT) in patients with thyrotoxicosis who received radioactive iodine (RAI) treatment. Methods This study was planned to be conducted with two different groups of people. There were 87 patients in the patient group and 98 controls. Participants were evaluated for atherosclerosis risk factors. Mean carotid IMT was measured from three consecutive traces at the common carotid artery bifurcation. Results The mean carotid IMT was 0.81 +/- 0.20 in patient group and this was higher than the controls (0.68 +/- 0.19) (p < 0.01). IM thickening was positively correlated with the applied RAI dose levels in the treatment group (p = 0.029). In patients with only HT, the data of the two groups showed a significant difference, with the average IMT being higher in the patient group than that of the control group (p: 0.011). Conclusion RAI used in the treatment of thyrotoxicosis increases the IMT of carotid artery independent of age and sex. This treatment yields better results with higher doses, and this effect is more marked in patients with HT. Hence, we believe that it is necessary to calculate the dose properly for hyperthyroid cases in which treatment with RAI is planned. In particular, the patients with HT need to be treated with the minimum possible dose. Further, carotid arteries should be evaluated with US following RAI treatment.
- Published
- 2015
29. Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats
- Author
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Haci Ramazan Yilmaz, Özlem Fentoğlu, Hüseyin Vural, Muhsin Özdem, Fatma Yeşim Kırzıoğlu, Ahmet Koçak, Efkan Uz, Ayse Yigit, BAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı, and Özdem, Muhsin
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Antioxidant ,medicine.medical_treatment ,medicine.disease_cause ,Antioxidants ,Superoxide dismutase ,Melatonin ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Periodontitis ,General Dentistry ,Saline ,Experimental periodontitis ,chemistry.chemical_classification ,biology ,Experimental Periodontitis ,business.industry ,Glutathione peroxidase ,Heart ,030206 dentistry ,medicine.disease ,Malondialdehyde ,Rats ,Oxidative Stress ,030104 developmental biology ,Endocrinology ,chemistry ,Cardiovascular Diseases ,biology.protein ,business ,Oxidative stress ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties. Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease. © 2017, Nihon University, School of Dentistry. All rights reserved., 1853-D-09, This study was supported by the Scientific Research Foundation of S?leyman Demirel University (Number: 1853-D-09).
- Published
- 2017
30. SERVET-İ FÜNÛN EDEBÎ TOPLULUĞUNUN DAĞILMA SÜRECİNDE 'ŞİİRİMİZ' MAKALESİ
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Ahmet Koçak
- Published
- 2013
31. A NEW MODEL IN THE MODERNIZATION OF THE OTTOMAN TURKISH SOCIETY: EUROPEN MURABBIYAS (GOVERNESSES)
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Ahmet Koçak
- Subjects
Roman,eğitim,Jozefino,Anjel,de Courton ,Literature ,Edebiyat ,Novel,education,Jozefino,Anjel,de Courton - Abstract
Osmanlı Devleti’nin Batılılaşma çabaları başta askerî alan olmak üzere çok daha öncelere dayanmasına karşın Tanzimat Fermanı’nın ilanı (1839) resmi başlangıç kabul edilir. Osmanlı Türk toplumunda pek çok meselede olduğu gibi eğitim alanında da bu dönemde önemli adımlar atılır. Özellikle kız çocuklarının eğitime kazandırılması ilk “İnas” kız okullarının 1870’li yıllarda açılmasıyladır. Edebî bir tür olarak Türk romanının ilk örneklerinin ortaya çıkması da bu dönemdedir. Toplum hayatına ayna tutan romanlarda bu devirde yaygınlaşan mürebbiyelere/enstitütrislere yer verilmiştir. İlk başlarda Avrupa’dan özel olarak getirtilen, daha sonra bir iş ve emek kazancına dönüşen bu meslekle varlıklı Osmanlı Türk ailelerinin yalılarında, konaklarında, köşklerinde Avrupalı mürebbiyeler görülmeye başlanır. Ahmet Midhat Efendi’nin Felâtun Bey’le Râkım Efendi’de Jozefino, Hüseyin Rahmi’nin Mürebbiyesinde Anjel ve Halid Ziya’nın Aşk-ı Memnu romanındaki de Courton bu dönemde öne çıkan ilk mürebbiye örneklerdir.Bu makale çerçevesinde Osmanlı Türk moderneleşmesinde mürebbiyelerin yeri üzerinde durulacak. İlk dönem romanlarında yer verilen mürebbiyelerin hangi özelliklere sahip oldukları, bunların toplum ve çocuk terbiyesinde nasıl bir fonksiyon icra ettikleri açıklanmaya çalışılacaktır., Even though Ottoman State’s efforts of westernization, especially in military fields, goes way back in history, the declaration of Tanzimat Edict (1839) has been accepted as its official beginning. Important steps were taken in the field of education during this period, as in many other fields of Ottoman Turkish society. Especially gaining the girls into the world of education for the first time was realized by the foundation of “Inas (girls)” schools in 1870s. The emergence of the first samples of Turkish novels as a literary style also happened in this period. Mürabbiyes/enstitutris (governesses) were given a place in the novels that shed light on social life. By means of this profession which was first imported from Europe and then turned into a way of making a living, European governesses started to appear in the mansions and cottages of the affluent Ottoman Turkish families. Jozefino in Ahmet Midhat Efendi’s novel titled Felâtun Bey’le Râkım Efendi, Anjel in Hüseyin Rahmi’s novelMürebbiye, and Courton in Halid Ziya’s novel Aşk-ı Memnu were first the examplary characters that represented governess for children in this period.In the framework of this article, we will deal with the place of the governesses in Ottoman Turkish modernization. We will try to explain the characteristics of the governesses who existed in the early novels and what function they carried out in the discipline and training of the children.
- Published
- 2016
32. The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping
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Mustafa, Ozsoy, Yucel, Gonul, Ziya Taner, Ozkececi, Ahmet, Bali, Ruchan Bahadir, Celep, Ahmet, Koçak, Fahri, Adali, Murat, Tosun, and Sefa, Celik
- Subjects
L-Lactate Dehydrogenase ,Anti-Inflammatory Agents ,Drug Evaluation, Preclinical ,Alanine Transaminase ,Constriction ,Antioxidants ,Rats ,Random Allocation ,Liver ,Ischemia ,Reperfusion Injury ,Animals ,Cytokines ,Aorta, Abdominal ,Aspartate Aminotransferases ,Rats, Wistar ,Biomarkers ,Melatonin - Abstract
Severe local and systemic tissue injuries can occur after restoration of tissue oxygenation which is also known as reperfusion injury. Our objective was to investigate the possible protective effects of melatonin against IR damage in hepatic tissue following infrarenal aortic occlusion.A total of twenty-one male Wistar-albino rats separated into three groups as follows: Group I: Laparotomy and dissection of the infrarenal abdominal aorta (AA) were concurrently performed. Group II: About 1 ml of 0.9% saline was intraperitoenally administered 30 min before and after the occlusion operation. After laparotomy and dissection, infrarenal AA was clamped for 30 minutes and then was exposed to two hours of reperfusion. Group III: The melatonin was administered 30 min before clamping of the infrarenal AA then 30 min of ischemia and two hours of reperfusion was applied.Serum aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase levels were remarkably higher in IR group, when compared with the sham group, and the laboratory tests returned to normal levels in IR+MEL group after treatment. Although serum IL-1β, IL-6, IL-18, TNF-α, and IFN- γ levels have decreased in treatment group following melatonin administration, this decrement was statistically significant for serum IL-18, TNF-α, and IFN- γ parameters compared with the IR group. Serum levels of TOC and OSI were decreased and tissue levels of TAC were increased by melatonin.As a result of this study, it can be suggested that melatonin has antioxidant, anti-inflammatory and hepatoprotective effects in case of IR.Aortic occlusion, Injury, Ischemia/Reperfusion, Liver, Melatonin.Dopo il ripristino della circolazione sanguigna e dell’ossigenazione possono verificarsi gravi danni locali e sistemici ai tessuti temporaneamente ischemici, noti come danni da riperfusione. Lo scopo di questo studio è stato quello di indagare sui possibili effetti protettivi della melatonina nei confronti dei danni sistemici da riperfuzione nel tessuto epatico a seguito dell’occlusione dell’aorta sottorenale. Per questo studio sono stati impiegati un totale di 21 ratti Wistar-albini di sesso maschile, suddivisi in tre gruppi: I gruppo – laparotomia e contemporanea dissezione dell’aorta infrarenale; II gruppo – somministrazione intraperitoneale di circa 1 ml di fisiologica al 0,9% di NaCl 30’ prima e dopo l’operazione di occlusione. Dopo la laparotomia e sua dissezione, l’aorta sottorenale è clampata per 30’ e quindi riabitata al circolo di riperfusione per 2 ore; III gruppo – 30’ prima del clampaggio dell’aorta sottorenale è stata somministrata la malatonina, seguita dal clampaggio aortico per 30’ e un periodo di riperfusione di 2 ore. Sono stati quindi dosati i tassi sierici di aspartate aminotransferasi, alanine aminotransferasi, and lattato dehydrogenase, risultati significativamente più elevate nei gruppi II e III rispetto al gruppo I di controllo. Gli esami di laboratorio sono tornati ai livelli normali nel III gruppo dopo il trattamento. Sebbene si sia avuto un decremento del tasso sierico di IL-1β, IL-6, IL-18, TNF-α, e IFN- γ nel gruppo trattato con melatonina, questo decremento ha assunto valore statisticamente significativo per i livelli sierici di IL- 18, TNF-α, e IFN- γ in paragone con quanto osservato nel II gruppo. I tassi sierici dello stato totale di antiossidanti tissutali (TOC) e dell’indice di stress ossidativo dei tessuti (OSI) sono risultati diminuiti e quelli della capacità antiossidante (TAC) risultano accresciuti dalla melatonina. Il risultato di questo studio suggerisce effetti antiossidanti della melatonina ed effetti epatoprotettivi nei confronti dei danni da riperfusione.
- Published
- 2016
33. The effects of midazolam and etomidate on the antioxidant system in the rat liver
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Dilek BAYRAM, Meral ÖNCÜ, Efkan UZ, Hacı Ramazan YILMAZ, Ayşe YİĞİT, and Ahmet KOÇAK
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Physiology ,Midazolam ,Cell Biology ,Superoxide dismutase ,Catalase ,Microbiology ,Catalase,etomidate,liver,malondialdehyde,midazolam,superoxide dismutase ,Liver ,Malondialdehyde ,Genetics ,Etomidate ,General Agricultural and Biological Sciences ,Molecular Biology ,Biyoloji - Abstract
This study was conducted to investigate the histopathological and biochemical effects of midazolam and etomidate, which are intravenous anesthetics used in surgical operations, on rat liver. There were 3 study groups each consisting of 9 animals: the control, midazolam, and etomidate groups. Midazolam and etomidate were administered 10 times with 1-day intervals. At the end of the study, tissues were taken for histological examination and biochemical analysis. We determined superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels in the liver. There was a slight increase in MDA level in the midazolam-exposed group when compared with the controls, and this was not statistically significant. However, SOD and CAT activities were significantly increased in the midazolam group. We found slight damage in histological sections in parallel to biological findings. MDA levels were significantly increased in the etomidate group and SOD and CAT activities were also prominent in this group. More histological changes like hepatocyte degeneration, vascular congestion, and mononuclear cell infiltration were observed in the etomidate group and this was statistically significant. We can say that these intravenous anesthetic agents may cause dose-dependent damage in tissue. Therefore, we think that one must be cautious of the administration duration and dose levels of anesthetics during surgical operations. © TÜBİTAK
- Published
- 2015
34. Savaşın Gölgesinde Yazılan Hikâyeler: Ömer Seyfettin’in Hikâyelerinde Savaşın Yansımaları
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Ahmet Koçak
- Subjects
Officer ,Politics ,Colloid and Surface Chemistry ,History ,Memoir ,Ömer Seyfettin,Rumelia/Balkans,story,soldier,war,conflict ,Physical and Theoretical Chemistry ,Theology ,Constitutional monarchy ,Ömer Seyfettin,Rumeli/Balkanlar,hikâye,asker,savaş,çatışma ,First world war - Abstract
Ömer Seyfettin , one of the leading names of modern Turkish story, was the son of a military official. He also got military education and served as an officer in the army.Particularly after the declaration of the Second Constitutional Monarchy, he was a close witness of the political developments and conflicts in Rumelia/the Balkans, where he served as an officer in the army. His stories include broad description of his military memoirs, and political and social events experienced in and behind the battlefront, beginning before the Balkan wars. The self-seeking, opportunist type of people who especially show up as a result of the wars are depicted as negative types. In this article, the stories of Omer Seyfettin written in the shade of war during the period from before the Balkan wars till the end of the First World War will be taken into consideration, Modern Türk hikâyesinin öncü isimlerinden Ömer Seyfettin (1884-1920), asker bir aileden gelmenin yanı sıra, kendisi de askerî eğitim almış, asker olarak görev yapmıştır. O, özellikle II. Meşrutiyet’in ilanından sonra bir asker olarak görev yaptığı Rumeli/Balkan coğrafyasında yaşanan siyasî gelişmelerin, çatışmaların yakın tanığı olmuştur. Onun hikâyelerinde askerlik hatıralarının, Balkan Savaşlarının öncesinden başlayarak, gerek cephede gerekse cephe gerisinde yaşanan siyasî ve sosyal olayları geniş tasviri yer alır. Özellikle savaşlar neticesinde ortaya çıkan menfaatperest, fırsatçı tipler olumsuz tipler olarak işlenir. Bu makalede Ömer Seyfettin’in Balkan Savaşları öncesinden başlayarak Birinci Dünya Savaşı ve sonrasını ele alan, savaşın gölgesinde yazılan hikâyelerinin değerlendirilmesi yapılacaktır.Anahtar Kelimeler: Ömer Seyfettin, Rumeli/Balkanlar, hikâye, asker, savaş, çatışma.Stories Written in the Shade of Wars: Reflections of Wars in the Stories of Ömer SeyfettinAbstract Ömer Seyfettin (1884-1920), one of the leading names of modern Turkish story, was the son of a military official. He also got military education and served as an officer in the army.Particularly after the declaration of the Second Constitutional Monarchy, he was a close witness of the political developments and conflicts in Rumelia/the Balkans, where he served as an officer in the army. His stories include broad description of his military memoirs, and political and social events experienced in and behind the battlefront, beginning before the Balkan wars. The self-seeking, opportunist type of people who especially show up as a result of the wars are depicted as negative types. In this article, the stories of Omer Seyfettin written in the shade of war during the period from before the Balkan wars till the end of the First World War will be taken into consideration.Keywords: Ömer Seyfettin, Rumelia/Balkans, story, soldier, war, conflict.
- Published
- 2015
35. The Efficacy of Combination Regime in Helicobacter Pylori Eradication: A Cross-Sectional Study from an Experienced Endoscopy Center
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Muzaffer Akinci, Ahmet Kocakusak, Adnan Hut, Adil Koyuncu, Okan Murat Akturk, Mikail Cakir, Mahmut Said Degerli, and Dogan Yildirim
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helicobacter pylori ,gastritis ,antibiogram ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim:The success of antibiotics used for eradication in the treatment of Helicobacter pylori (Hp)-positive gastritis is controversial. This study aims to evaluate the post-treatment eradication success/failure of Hp-positive gastritis cases, discuss antibiotic resistance, and what we can do additionally.Methods:The data of 1,471 patients who underwent upper gastrointestinal endoscopy between January 1 and December 31, 2019, were retrospectively evaluated through the hospital digital recording system. Of these, data of 126 patients who have been diagnosed with HP-positive gastritis and treated with a trio of clarithromycin, amoxicillin, and omeprazole were analyzed. Initial and control endoscopic pathologies and Hp-positivity were compared.Results:In the control of 126 patients, 87 (69%) patients had a normal endoscopic appearance, but only 46 (36.5%) patients were normal in the histopathological examinations of biopsies. Regardless of the severity, complete eradication of Hp was possible in 31 (24.6%) patients. There was no statistically significant difference in Hp detection rates after treatment (p=0.719 for 1+, p=0.583 for 2+, p for 3+)=0.980).Conclusion:In gastritis cases, Hp positivity continues despite the treatment, although the pathological severity changes. It is appropriate to discuss the effectiveness of routine treatments and to take culture/antibiogram, even bismuth including preparations to the forefront.
- Published
- 2021
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36. II. MEŞRUTİYET DÖNEMİ OSMANLI MATBUATINDA 'TONGUÇ' [TONGHIDJE] GAZETESİ VE ROMANYA TÜRKLERİ İÇİN ÖNEMİ
- Author
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Ahmet Koçak
- Subjects
Tonguç [Tonghidje]gazetesi,Türk basını,Balkanlar - Abstract
Osmanli matbuatinda II. Mesrutiyet’in ilanindan (24 Temmuz 1908) hemen sonra olusan ozgurluk havasi icerisinde cok sayida yeni dergi ve gazete yayin hayatina baslamis; bu dergi ve gazeteler halkin aydinlatilmasi, bilgi ve kultur seviyesinin yukselmesinde onemli bir fonksiyon icra etmislerdir. II. Mesrutiyet’in ilanindan sonra yayin hayatina giren gazetelerden birisi de Tonguc [Tonghidje] ’tur. Mirza Sait Bey tarafindan 11 Subat 1324 [24 Subat 1909] - 19 Mart 1325 [1 Nisan 1909] tarihleri arasinda 36 (otuz alti) sayi yayinlanan gazete, sadece genis Osmanli cografyasinda degil, Musluman Turklerin yasadigi Kirim, Romanya gibi yerlerde de yakindan ve ilgiyle takip edilmistir. Tonguc gazetesi sayfalarinda makale, siir, mektup gibi edebi turlere yer vermis olup, bunun yaninda Avrupa’dan, Balkan cografyasindan ve Islam dunyasindan aktardigi haberlerle de onemli bir islev gormustur. Ayrica, basta saglik olmak uzere, ciftcilik, bahcivanlik gibi tarim alanlarinda da halki bilgilendirme ve onlarin kulturel seviyelerini artirma noktasinda yazilar yayimlanmistir. II. Mesrutiyetten cumhuriyete uzanan surecte donemi anlamak acisindan gazete ve dergilerin buyuk onemi vardir. Bu yonuyle Tonguc gazetesi birlestirici ve aydinlatici vasfiyla matbuat tarihimizde onemli bir fonksiyonu olmustur. Bir baska ifadeyle, Osmanli icinde ve disinda yasayan Turk halkinin karsilastiklari sorunlara Tonguc gazetesi bir ayna vazifesi gordugu soylenebilir. Bu calismada II. Mesrutiyet sonrasi yayin hayatina dahil olan Tonguc gazetesi ilk defa incelenmis ve bu gazetenin Romanya cografyasinda yasayan Musluman Turkler acisindan ifade ettigi anlam degerlendirilmistir.
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- 2015
37. The Synthesis of Three New Macrocyclic Ligands and Preparation of Some of Their Cationic Complexes
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A. Dinçer Bedük, Mehmet Sezgin, Şeref Ertul, and Ahmet Koçak
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Inorganic Chemistry ,Chemistry ,Polymer chemistry ,Cationic polymerization ,Physical and Theoretical Chemistry - Abstract
In this study the synthesis of macrocyclic ligands 15,21-dinitro-2,5,8,ll-tetraoxatricyclo(17,4,0,012′17) tricosa-1 (23),12,14,16,19,21-hexaene-3,10-dione (I); 18,24-dinitro-2,5,8,1l,14-pentaoxatricyclo(20,4,0,015,20) hexacosa-l(26),15, 17,19,22,24-hexaene-3,13-dione (II) and 15,21-di-t-butyl-2,5,8,11-tetraoxatricyclo(17,4,0,012,17) tricosa-1(23),12,14,16, 19,21-hexaene-3,10-dione (III) are described. Attemption of the preparation of their complexes in crystalline form with NaClO4.H2O, KC1O4, and Ba(C1O4)2.3H2O are discussed.
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- 1993
38. Müsameretname ve Yazarı Emin Nihat Bey'e Dair Yeni Bilgiler
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Ahmet Koçak
- Published
- 2015
39. Comparison of Two Different Central Venous Access Device Insertion Techniques: No Evil in Details
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Mürşit Dinçer, Ahmet Kocakuşak, Adnan Hut, Ümit Gür, Gamze Çıtlak, and Muzaffer Akıncı
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Central venous access devices ,complications ,fluoroscopy ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim:Central venous access devices (CVADs) have been used for prolonged infusion chemotherapy and have facilitated the problem of vascular access. The aims of this study were to analyse the results and complications of two CVAD implantation techniques.Methods:We performed a retrospective study of 118 implantable venous access devices inserted via the subclavian vein using two different surgical techniques between January 2015 and June 2017 in İstanbul Haseki Training and Research Hospital, Clinic of General Surgery. While the devices were placed under fluoroscopic guidance in group 1, they were placed without fluoroscopy in group 2. All procedures were performed under sedation and local anesthesia. All devices were placed at the anterior chest wall over the pectoralis fascia. Outcome and complications were followed and recorded elaborately.Results:A total of 118 venous access devices were implanted. During follow-up, a total of eight complications were observed. Pneumothorax was observed in five, wound infection in two and catheter fracture was observed in one patient. There was no statistically significant difference in complications between the two groups.Conclusion:CVADs increase quality of life of patients with oncologic diseases during chemotherapy. Common periprocedural complications of CVADs are pneumothorax, wound infection and catheter occlusion. In critical patients, the use of fluoroscopy may be helpful in reducing complications. However, since fluoroscopy increases costs and requires experience, CVAD insertion under fluoroscopy guidance may not always be possible. There is also a risk of radiation exposure when using fluoroscopy. In regard to comparison of the two techniques, fluoroscopy guidance did not alter the results and its superiority over the other technique was not observed. Although image-guided insertion of subcutaneous chest ports has advantages over unguided insertion, the latter can be used in a selected group of patients in experienced hands.
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- 2019
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40. Effect of Intraoperative Neuromonitoring on Voice Quality in Total Thyroidectomy
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Erdinç Çekiç, Turgut Dönmez, Özgür Sürmelioğlu, Sina Ferahman, Engin Hatipoğlu, and Ahmet Kocakuşak
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Neuromonitoring ,thyroidectomy ,voice quality ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim: Thyroid gland surgery has a risk of serious complications. Advancements in technology have led to improvements in complications but significant challenges to preserving voice and airway function still remain. The purpose of this study was to evaluate voice quality following total thyroidectomy under neuromonitoring and effect of intraoperative neuromonitoring (IONM) on identification of the recurrent laryngeal nerve (RLN) and external branch of the superior laryngeal nerve (EBSLN). Methods: A total of 80 patients scheduled for total thyroidectomy between May 2015 and March 2016 were included in the study. All the RLNs and EBSLNs were identified. Voice assessment included preoperative and postoperative fiberoptic laryngoscopy, analysis of Jitter, Shimmer, and fundamental frequency and the Voice Handicap index-10. Results: Eighty patients were included in this study (71 females, nine males). There was no significant difference between mean initial and post-dissection electromyographic amplitudes with RLN and EBSLN stimulation. The rate of postoperative transient RLN palsy per nerve at risk was 4.375% (7/160) and null for permanent RLN palsy (0%, 0/160). Conclusion: Both subjective and objective assessments revealed preservation of voice quality in patients after total thyroidectomy under neuromonitoring. IONM may be used effectively and safely in order to identify the EBSLN during thyroid surgery.
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- 2018
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41. Antioxidant Effect of Ukrain Versus N-Acetylcysteine Against Acute Biliary Pancreatitis in An Experimental Rat Model
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Sezgin Zeren, Zulfu Bayhan, Cengiz Koçak, Fatma Emel Koçak, Mehmet Huseyin Metineren, Bircan Savran, Havva Kocak, Mustafa Cem Algin, Cuneyt Kahraman, Ahmet Kocak, and Suleyman Cosgun
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antioxidants ,acetylcysteine ,oxidative stress ,pancreatitis ,ukrain ,biliary system ,Surgery ,RD1-811 - Abstract
Purpose/Aim: Oxidative stress plays an important role in the pathogenesis of acute pancreatitis (AP). We compared the therapeutic effects of Ukrain (NSC 631570) and N-acetylcysteine (NAC) in rats with AP. Materials and Methods: Forty male Sprague Dawley rats were divided into four groups: controls; AP; AP with NAC; and AP with Ukrain. AP was induced via the ligation of the bile–pancreatic duct; drugs were administered intraperitoneally (i.p.) 30 min and 12 h after AP induction. Twenty-four hours after AP induction, animals were sacrificed and the pancreas was excised. Levels of malondialdehyde (MDA) and nitric oxide (NO), and activity levels of tumor necrosis factor (TNF)-α, and myeloperoxidase (MPO) were measured in tissue samples. Total oxidant status (TOS), total antioxidant status (TAS), and total bilirubin, as well as activity levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), amylase and lipase were measured in serum samples. Pancreatic tissue histopathology was also evaluated. Results: Test drugs reduced levels of MDA, NO, TNF-α, total bilirubin, AST, ALT, TOS and MPO, amylase and lipase activities (P < 0.001), and increased TAS (P < 0.001). Rats treated with test drugs attenuated AP-induced morphologic changes and decreased pancreatic damage scores compared with the AP group (P < 0.05). Both test drugs attenuated pancreatic damage, but the therapeutic effect was more pronounced in rats that received Ukrain than in those receiving NAC. Conclusions: These results suggest that treatment with Ukrain or NAC can reduce pancreatic damage via anti-inflammatory and antioxidant effects.
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- 2017
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42. Assessment of the Pre-operative Nutritional Status of Patients who were Scheduled for Elective Surgery and Determination of Nutritional Support Requirements
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Bahri Özer, Ahmet Kocakuşak, Cihad Tatar, Adil Koyuncu, Suat Benek, Hüsnü Aydın, Gamze Çıtlak, and Halit Özgül
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Albumin ,body mass index ,elective ,nutrition ,Nutritional Risk Screening 2002 ,Subjective Global Assessment ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim: We aimed to evaluate the nutritional status with clinical, antropometric and laboratory methods in patients who were scheduled for elective surgery. Methods: Retrospective evaluation of 90 patients in a period of 4 years was performed. Patients with tumors (group 1) were compared with controls (group 2) in regard to nutritional status. Student t-test, Mann-Whitney U test and chi-square test were used for statistical analysis. Results: The mean age of patients in group 1 (3 males, 8 females) and group 2 (35 males, 44 females) was 62.8±11.0 and 47.7±16.2 years, respectively. The mean body mass index (BMI) was 30.1±6.6. Triceps thickness and circumference of the upper mid-arm were 2.2±0.8 and 28.6±4.2 cm, respectively. All patients had a Subjective Global Assessment (SGA) score A, but two patients were classified as having moderate nutritional risk according to Nutritional Risk Screening (NRS) 2002. The mean length of hospital stay was 2.6±2.4 days. Complications were observed in four patients of group 2 and in two patients of group 1. Gender, SGA score, albumin, prealbumin, BMI, triceps thickness, circumference of the upper mid-arm and complication rates were statistically similar between the groups. There was a statistically significant difference in age, NRS 2002, gastrointestinal system findings, length of hospital stay, sedimentation and fasting blood glucose levels between the groups. Conclusion: Patients with nutritional risk can be detected using the NRS 2002. Nutritional support was necessary in 2% of all cases and in 18% of group 1 patients. However, advantages of antropometric measurements, biochemical tests, BMI and SGA could not be shown.
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- 2016
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43. THE ROLE OF SERUM CK-18, MMP-9 AND TIPM-1 LEVELS IN PREDICTING R0 RESECTION IN PATIENTS WITH GASTRIC CANCER
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Sevki PEDUK, Mursit DINCER, Cihad TATAR, Bahri OZER, Ahmet KOCAKUSAK, Gamze CITLAK, and Muzaffer AKINCI
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Adenocarcinoma ,CK-18 ,MMP-9 ,TIMP-1 ,Gastrectomy ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
ABSTRACT Background: Gastric cancer is the 3rd most common cause of death in men and the 5th common in women worldwide. Today, surgery is the only curative therapy. Currently available advanced imaging modalities can predict R0 resection in most patients, but it can only be detected with certainty in the perioperative period. Aim: To determine the role of serum CK18, MMP9, TIMP1 levels in predicting R0 resection in patients with gastric cancer. Methods: Fifty consecutive patients scheduled for curative surgery with gastric adenocarcinoma diagnosed between 2013-2015 were included. One ml of blood was taken from the patients to analyze CK18, MMP9 and TIMP1. Results: CK18, MMP9 and TIMP1 levels were positively correlated with pathological N and the stage (p
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- 2018
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44. Can Two-Port Hand Assisted Laparoscopic Appendectomy be a Good Alternative to Open and Three Port Appendectomies?
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Turgut Dönmez, Oğuzhan Sunamak, Adnan Hut, Muzaffer Akıncı, Ahmet Kocakuşak, Hüseyin Avaroğlu, Doğan Yıldırım, and Sina Ferahman
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Laparoscopic surgery ,appendectomy ,hand assisted laparoscopic appendectomy ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim: Laparoscopic appendectomy has been performed in increasing numbers since it was first described in 1980. Nowadays, it is being performed by using the three-, two- and single-port methods. We performed two-port hand-assisted laparoscopic appendectomies and reported our prospective results. Methods: Forty consecutive patients (27 males and 13 females) with acute appendicitis according to physical examination and ultrasonography findings were operated on with two-port hand-assisted laparoscopic appendectomy by the same surgeon between 2011 and 2015. Five-mm (subumbilical) trocar for endoscopy and 10-mm (McBurney) trocar were used to perform appendectomy. The appendix was taken out through the lumen of the 10-mm trocar and ligated extracorporeally and appendectomy was completed extracorporeally. If necessary, another 5-mm trocar was also placed at the left lower quadrant in difficult cases and appendectomy was completed in the same way as described. Results: The mean duration of the surgical procedure was 23.175 minutes and the mean duration of the whole operation was 41.3 minutes. All the patients except for one were discharged on the first postoperative day. A third port was necessary in 8 (8/40) cases. The mean hospitalization time was 1.075 days. Conclusion: The two-port hand-assisted laparoscopic technique combines both the advantages of open and laparoscopic surgeries, providing a shorter operation time and hospital stay. In difficult cases, one should not hesitate to insert a third 5-mm port and complete the assisted appendectomy.
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- 2016
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45. Effects of thymoquinone against cisplatin-induced cardiac injury in rats
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Fahri Adalı, Yucel Gonul, Ahmet Kocak, Yasemin Yuksel, Gulay Ozkececi, Cigdem Ozdemir, Kamil Tunay, Mehmet Fatih Bozkurt, and Ozlem Gulec Sen
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Cisplatin ,Cardiotoxicity ,Genes, bcl-2 ,Rats ,Surgery ,RD1-811 - Abstract
PURPOSE: T o investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury. METHODS: A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows: Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two days prior to CP injection and on third day, CP at 15 mg/kg dose was intraperitoneally administered and TQ treatment continued until fifth day) and Group 4 (TQ at 40mg/kg/day dose for five days). RESULTS: There was a significant increment in CP group in terms of congestion, edema and pycnotic nuclei in myocardial fibers, comparing with other groups. TQ group exhibited significant increase in expression of antiapoptotic protein Bcl-2, comparing with CP group (p
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- 2016
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46. MEVLÂNA ÂŞIĞI KONYALI BİR ŞAİR: VEYSEL ÖKSÜZ
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Ahmet KOÇAKOĞLU
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Language and Literature - Published
- 2016
47. Synthesis of Benzene-1,2-bis(aminoglyoxime) and Its Complexes with Nickel(II), Copper(II), Cobalt(II), Cadmium(II), Zinc(II), and Uranyl(VI)
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Özer Bekĉroĝlu and Ahmet Koçak
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Ligand ,Inorganic chemistry ,chemistry.chemical_element ,Zinc ,Uranyl ,Medicinal chemistry ,Copper ,Inorganic Chemistry ,Metal ,chemistry.chemical_compound ,Nickel ,chemistry ,visual_art ,visual_art.visual_art_medium ,Physical and Theoretical Chemistry ,Benzene ,Cobalt - Abstract
Benzene-1,2-bis(aminoglyoxime)(LH4) has been prepared from o-phenylenediamine and anti-chloroglyoxime at -5[ddot]C. The Ni(II) and Cu(II) complexes of LH4 have a polymeric structure in which the ligand coordinates through the N atoms of the oximes. The Co(II) complex [(LH2) Cl2 (H2O)2Co2] is binuclear and coordinates through N and O atoms. The ligand with tetraoxime donor sites forms mononuclear complexes with Cd(II) and Zn(II) [(LH2)M, where M = Cd(II) or Zn(II)]. In the UO2(VI) complex, the metal/ligand ratio is 2:1 and a hydroxo-bridged polymeric structure is proposed. The structures of the complexes have been postulated on the basis of elemental analyses, magnetic measurements, i.r., and u.v.-visible spectra.
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- 1984
48. The Ever-Changing Configuration of the Completion Thyroidectomy in the Last Decade
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Suat Benek, Ahmet Kocakuşak, Bahri Özer, Mehmet Celal Kızılkaya, Fazilet Erözgen, Fatih Çiftçi, Hüsnü Aydın, and Cihad Tatar
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Completion thyroidectomy ,revision ,remnant ,cancer ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim: We aimed to evaluate the results of fine needle aspiration biopsy (FNAB), first and second surgical interventions and complication rates in patients who underwent completion thyroidectomy (TT). Methods: We retrospectively evaluated medical records of 43 patients who had been operated on between January 2011 and December 2013. Results: All patients underwent lobectomies both in their first and second surgical interventions. Thirty-eight (88.37%) patients were female and 5 (11.63%) were male. The mean age of the patients was 43.34±15.19 years. Malignancy was detected in 34 patients in the first surgery (papillary cancer in 31, medullary cancer in 2, and follicular cancer in 1). Nine patients were found to have a contralateral cancer according to the second surgery results. Nine patients, who had no cancer in the first operation, had still no malignancy in the contralateral lobe. Right lobectomy in 29 and left lobectomy in 14 patients were performed in the first operation. While FNAB detected benign cases with a rate of 27.2%, it could detect malignancies with a rate of 29.4%. Nerve injury and permanent hypocalcemia were not detected although the rate of temporary hypocalcemia was 39.5% (17 patients). Conclusion: Completion TT is a safe method nowadays since the number of patients with subtotal thyroidectomy with more than one lobe declined and new techniques such as nerve monitorization have been employed. (The Medical Bulletin of Haseki 2015; 53:225-8)
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- 2015
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49. Comparison of Partial Cystectomy and Tube Drainage Technique with Other Surgical Methods in Hydatid Cysts of the Liver
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Bahri Özer, Ahmet Kocakuşak, Suat Benek, Ömer Güngörür, Fazilet Erözgen, Hüsnü Aydın, Adil Koyuncu, İshak Sefa Tüzün, and Rafet Kaplan
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Hydatid cyst ,cystotomy ,tube drainage ,unroofing ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim: Since radical surgical methods in the treatment of hydatid cysts of the liver have been replaced by less invasive surgical interventions nowadays, partial cystectomy and tube drainage (PCTD) have been more popular. The evaluation of PCTD technique was aimed using the data obtained from the medical records of patients who had been operated on in our surgical clinic. Methods: Data of patients who had been operated on using the PCTD technique between 2007 and 2012 were compared with those of patients in whom different surgical methods had been employed. The PCTD and control groups consisted of 41 and 14 patients, respectively. The study was conducted retrospectively according to the hospital data and patient files, surgery and pathology records in addition to computer data and verbal information of the patients. Chi-square test was used in the statistical analysis where a p value of less than 0.05 was considered statistically significant. Results: The mean age of the subjects in the PCTD and control groups were 48 and 33.21 years, respectively. PCTD (n=41) and control (n=14) groups consisted of 22 females versus 19 males and 11 females versus 3 males, respectively. Single cysts were found in 34 patients in PCTD group versus multiple cysts in the remaining 7. Single cyst was found in 10 patients in the control group versus multiple cysts in the remaining 4. Bilateral cyst/cysts in 7, right-sided in 29 and left-sided in 5 patients in PCTD group versus bilateral cyst/cysts in 1, right-sided cyst/cysts in 11 and left-sided cyst/cysts in 2 patients in the control group were found. Complications occurred in 3 of 41 (7.31%) and in 2 of 14 (14.28%) patients in the PCTD and control groups, respectively. PCTD applicability statistically significantly correlated with male gender and the presence of a single cyst, but age and location of the cyst. Moreover, complication rate was significantly lower in the PCTD group than in controls. Conclusion: PCTD is a reliable and easily applicable method of choice when compared to other surgical interventions with less complication rates.
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- 2014
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50. The Evaluation of a Special Clinical Series: Breast Cancer in Breastfeeding Mothers and Delay in Diagnosis
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Mehmet Celal Kızılkaya, Ahmet Kocakuşak, Ertuğrul Gazi Alkurt, Fazilet Erözgen, Muzaffer Akıncı, Rafet Kaplan, and Sefa Tüzün
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breastfeeding ,breast cancer ,lactation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Medicine - Abstract
Objective:We aimed to investigate lactating mothers who were admitted to our breast polyclinic and diagnosed as breast cancer.Materials and Methods:Ten lactating mothers with breast cancer from 112 breast cancer patients among 2380 patients admitted to our breast diseases policlinic were evaluated retrospectively.Results:Ten of 112 breast cancer patients were lactating women. The mean age of those patients was 33.2 (28-39) years. The mean lactating period was 8.4 months (5-12 months). The average number of children of the patients was two (1-3 child per patient). The results of the tru-cut biopsis were invasive ductal carcinoma in all patients. All patients were triple negative in regard to receptors, except for one, in whom oestrogen and c-erbB2 receptors were positive, whereas the progesterone receptor was negative. Two of the patients were in follow up due to a galactocele for three months. Four patients had multicentric disease in the same breast. Bone metastasis in three, left supraclavicular lymph node metastasis in two and locally advanced breast carcinoma in one patient were detected. Three patients underwent modified radical mastectomy, one patient was given neoadjuvant treatment, however the remaining six patients were given adjuvant oncological treatment.Conclusion:The diagnosis of breast carcinoma in lactating mother is delayed and therefore, prognosis as well as mortality are negatively influenced.
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- 2014
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