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In this paper, four new mono-nuclear Ni(II), Pd(II), Pt(II) and Zn(II) complexes were prepared by using a bi-dentate Schiff base ligand, (E)-2-(((4-bromo-2,6-dichlorophenyl)imino)methyl)-5-chlorophenol (BrcOH), with bivalent ions in a methanol and distil water mixture as solvent in presence of NaOH as base. The structures of the prepared compounds were characterized by spectroscopic techniques (IR and 1H NMR), CHN analysis, and molar conductivity. The M(II) (Ni, Pd and Pt) ions are four-coordinated by a bi-dentate N2O2 donor ligand, forming square planar geometry, whereas the Zn(II) is coordinated as a tetrahedral geometry. The newly synthesized compounds, which include the Schiff base ligand and its complexes, underwent antibacterial screening against E. coli and S. aureus. The results demonstrated a remarkable and noteworthy biological activity of these compounds against these pathogenic bacterial strains. Different binding energies showed good correlation, with Pd showing the strongest binding. Small energy differences indicated high reactivity, with Ni and Pd complexes being the most reactive. Electrophilicity index exhibited electron-accepting properties, with Zn showing the highest reactivity. The dipole moments showed polarity and charge separation, with Pt having the highest polarity. We evaluated the pharmacokinetic properties (ADME) of a ligand and its metal complexes using the Swiss ADME website. The results of the in-silico prediction of physicochemical properties revealed that ten compounds in total adhered to Lipinski's rule.

Nine Hg(II) complexes, [Hg(DiphtS)2(L-L)](2–7) {where, HDiphtS = 4,5-diphenyl-1,2,4-triazole-3-thiol; L-L = bis(diphenylphosphino)ethane (dppe) (2); 1,3-bis(diphenylphosphino)propane (dppp)(3); 1,4-bis(diphenylphosphino)butane (dppb)(4); 1,1′-bis(diphenylphosphino)ferrocene (dppf)(5); 2,2′-bipyridine (Bipy)(6) and 1,10-phenanthroline (Phen)(7) } or [Hg(DiphtS)2(L)2] (8–9) {where L = triphenylphosphine (Ph3P) (8) and triphenylphosphine sulphide (Ph3PS) (9)}, have been prepared form the reaction of [Hg(DiphtS)2](1) with phosphine or amine as co-ligands. Then characterized by the IR, NMR (1H and 31P) spectroscopy, elemental analysis, molar conductivity. The results supported the monodentate behaviour of HDiphtS ligand in all complexes (1–9) in anion form through the sulfur atom. Complexes 1, 2 and 6 have been used as single source precursors for the preparation of ethylene-diamine capped HgS-nanoparticles. Powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM), have been used to characterize the HgS nanoparticles.

The present study aimed to develop polyethylene glycol–liquid crystals (PEG-LC) ointment formulations, assess their formulation characteristics, and establish their biocompatibility and impact on transdermal drug administration. PEG-LC formulations were prepared using a hydrophilic molecule, p-aminobenzoic acid (PAB). Formulation characterizations such as small-angle X-ray scattering, viscosity, pH, zeta potential, and the particle sizes of the formulations were examined to determine the physicochemical properties of the prepared formulations. The drug release profile of PEG-LC ointment formulations was assessed with a dialysis membrane. In vitro skin permeation testing was performed to establish whether the PEG-LC formulations improved drug skin penetration. The MTT and comet assays were performed to assess the biocompatibility of the formulations. Our data showed that the method is effective in forming hexosome-type PEG-LC formulations and that they were biocompatible. Furthermore, the PEG-LC formulations significantly improved PAB skin penetration when compared with commercial PEG. The PEG-LC formulation is a promising carrier for the delivery of hydrophilic drugs.