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Your search keyword '"Ahmed N. Elkattan"' showing total 2 results
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2 results on '"Ahmed N. Elkattan"'

1. Ameliorative effect of licorice extract against the detrimental effect of glyphosate-based pesticide: Toxicity and health

Author

Ahmed N. Elkattan, Sayad El-saadany, Mohamed Azzazy, Tarek M. Okda, Maha Mamdouh, Osama Ahmed, Ali H. El-Far, Manar ElKhayat, Ghadeer M. Albadrani, Muath Q. Al-Ghadi, Mohamed M. Abdel-Daim, and Hala El Daous

Subjects
Glyphosate-based pesticide, Toxicity, Licorice (Glycyrrhiza glabra), Antioxidant, Apoptosis, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

This study sheds the light on the potential of licorice (Glycyrrhiza glabra) root aqueous extract as a cornerstone for mitigating and detoxifying the residues of the widely used agricultural Glyphosate-based pesticides (GBPs). This study examined the GBPs toxic effects on kidney, liver, thyroid functions, and apoptosis using 50 adult male albino rats. All rats were divided into 5 groups, with 10 each. Control: served as untreated rats. GBP: rats were treated with 1 mL glyphosate solution 24 % orally for three weeks. The glyphosate-treated rats were gavaged with licorice root aqueous extractsolution (100, 200, and 300 mg/mLdistilled water, respectively) daily for three weeks. Licorice root aqueous extract solution (300 mg/mL distilled water) yielded notable reductions in liver, kidney enzymes, albumin, and AFP levels within the serum. Immunological tests, including immunohistochemical evaluations of caspase-3 and TNF-α expressions revealed a dose-dependent attenuation of apoptosis and inflammation with licorice intervention. This will provide a valuable perspective for agricultural practices future and paving the way for a more sustainable approach for using GBPs in animal agriculture industries.

Published
2024
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2. ANTICANCER EFFECTS OF TOW TRADITIONAL DRINKS HIBISCUS (Hibiscus sabdariffa LINN) AND LIQUORICE (Glycyrrhiza glabra)

Author

S. S. El-Saadany, J. Abdalmuneim, Ahmed N. Elkattan, A. M. Gomaa, and A. L. ElSayed

Subjects
0303 health sciences, Traditional medicine, biology, business.industry, Hibiscus sabdariffa, medicine.disease, biology.organism_classification, Hibiscus, Oxidative dna damage, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Hepg2 cells, medicine, Glycyrrhiza, Liver cancer, business, IC50, 030304 developmental biology, 030215 immunology
Abstract

Breast cancer (MCF-7), as well as liver cancer (HepG2), were the leader among newcancer cases. The objective of this study is to assess the viability percentage of tow traditional drinks(hibiscus and liquorice extracts) toward human breast and liver cancer cell lines at differentconcentrates from 250 to 5000 μg/ml in hibiscus extract and from 50 to 3000 μg/ml in liquoriceextract. The viability percentage of hibiscus on breast and liver cancer cell lines were 86.9% and84.7% at 5000 μg/ml, respectively. The IC50 of the hibiscus extract were 18478.6 μg/ml and 16159μg/ml breast and liver cancer. In addition, the viability percentage of liquorice extract on breast andliver cancer cell lines were determined. Results revealed that liquorice extract has possessed high anticarcinogenicproperties it was zero (%) at 3000 μg/ml for breast cancer and 5% for liver cancer atsame concentration, the IC50 was 491.7 μg/ml in breast cancer and was 125 μg/ml in liver cancer cellline. DNA damage was determined to detect oxidative DNA damage in HepG2 cell line. This enhances therole of these traditional drinks especially liquorice as anti-cancer agents.

Published
2019

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