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Diabetes mellitus (DM) is a polygenic illness that affects many other organs. In people with type 2 diabetes, urinary tract infection is the most prevalent, the most severe, and has the worst consequences. They are also more frequently caused by microorganisms that are resistant to antibiotics. Immune system dysfunction, poor metabolic regulation, and inadequate bladder emptying owing to autonomic neuropathy may all contribute to these individuals' increased risk of urinary tract infections. The novel anti-diabetic sodium glucose cotransporter 2 inhibitors were not shown to raise the likelihood of symptomatic urinary tract infections appreciably. Urinary tract infection symptoms are comparable to those seen in people without diabetes, while some patients with diabetic neuropathy may exhibit changed clinical findings. The existence of symptoms, the severity of systemic symptoms, whether the infection is limited in the bladder or also includes the kidney, the presence of urologic abnormalities, concomitant metabolic disturbances, and renal function all influence treatment. There is no evidence that diabetic people with asymptomatic bacteriuria should be treated. Diabetes length, age, gender, method of drug administration, kind of medicines used in diabetes, poor glycemic control, obesity, unsanitary settings, sexual intercourse, and type of DM are all risk factors for UTI in diabetic patients. Antibiotic usage on a daily basis has rendered numerous harmful microorganisms resistant to their effects. In the long run, if UTI in diabetes people is not treated, it might lead to serious problems. Furthermore, the pattern of antibiotic resistance varies by geographical area. As a result, the use of susceptible antibiotics to treat UTI in diabetes patients has become critical. Medline and PubMed public database searches was carried out for papers written all over the world on UTI in diabetic patients. No predictive analytics technology was used. To evaluate the initial results and the methods of conducting the paper, the group members reviewed the data.

Background: Bone marrow and stem cell transplantation have become conventional therapy, with the potential to cure a variety of hematologic malignancies and immunologic diseases. Severe infection is still a potentially fatal complication following transplantation, contributes significantly to morbidity, and may demand ICU admission. Objectives: The study aims to summarize current evidence on the prevalence, risk factors, and management approaches of irritable bowel syndrome in Saudi Arabia. Methodology: For article selection, the PubMed database and EBSCO Information Services were used. All relevant articles relevant to our topic and other articles were used in our review. Other articles that were not related to this field were excluded. The data was extracted in a specific format that was reviewed by the group members. Conclusion: the result of the 12 studies included, proves the high risk of infections after bone marrow transplantation and its high mortality effect. Post transplantation patient's immune system is vulnerable, opportunistic infections occur such as viruses and fungi. The highest prevalence recorded in Adenovirus infections reaching 29% of patients throat swaps, urine, and stool samples come positive affirming the diagnosis.

Background: Although the eyes represent 0.1% of the total human body, such organs are exposed to multiple injuries, some of which possibly lead to permanent loss of vision. Chemical injuries occurring on the eyes is deemed to be a major ophthalmic emergency, requiring immediate clinical assessment and initiation of treatment. Concerning the awareness of the Saudi population regarding the risks of chemical-based ophthalmic injuries and the permanent repercussions brought about by such incidents, together with the proper steps and actions that should be taken in such cases, this has unfortunately still a degree of paucity within the state. In addition, it is of great importance to recognize areas of shortcomings by health care workers, in order to provide accurate and non-complex medical facts regarding chemical-based ophthalmic injuries Aims: This study focused on evaluating the general population’s awareness of the immediate responses that are required, following ophthalmic chemical injury incidents within the Asir province of Saudi Arabia. Methodology: This study contained a questionnaire that was randomly distributed across all segments of population in the Asir province of the Kingdom of Saudi Arabia (KSA), through various social media, entitled ‘The eyes are arguably the most important sensory organ of the human body’. This investigation lasted a total time span of six months (May – October 2021) and its design was classified as a descriptive cross-sectional survey of the local Asir community. Results: In relation to overall population awareness regarding chemical eye injury within the Asir region, KSA, among this cohort, 288 (48%) had good awareness level regarding chemical eye injury and its management, while 312 (52%) had poor awareness. Through our research we found out that individuals in the Asir population require greater awareness regarding the immediate steps of management in cases of ocular chemical eye injuries. Furthermore, there is a need to establish that the only solution required to irrigate the eye is water, with a mechanism of eye washing from the middle part of the face to the tip of the eye. Conclusions: These results should be evaluated by the Ministry of Health and the appropriate actions should be made, such as health awareness campaigns, regarding ocular chemical injuries and immediate corrective actions, in order to improve knowledge and to create a healthier society. Key words: ocular chemical injury, community awareness, Abha

Background: Obesity-related morbidity continues to increase in Saudi Arabia, especially among school students, who constitute a vulnerable population since they can be highly influenced by the western culture and rapid globalization. Aim of Study: To examine the relationship between obesity and negative emotional states among male secondary school students. Methodology: This was a cross-sectional study conducted among male secondary school students in Abha City, Saudi Arabia during the academic year 2019-2020. A multistage cluster sampling technique was followed by the researchers, in order to recruit participants. The standardized Arabic version of Depression Anxiety Stress Scale (DASS-21) was used by the researchers for determining prevalence and levels of depression, anxiety and stress symptoms among participants. Results: Three hundred and ninety eight students participated in the study. Their mean age (±SD) was 16.98±0.93 years. Overweight and obesity was present among 44.2% and 38.4% of participants respectively. The overall prevalence rates for symptoms of depression, anxiety and stress among participants were 57%, 64.6% and 39.4%, respectively. There were statistically significant associations between obesity and symptoms of depression, anxiety and stress (p

Backgrounds: Child abuse or child maltreatment is physical, sexual, or psychological maltreatment or neglect of a child or children, especially by a parent or other caregiver. Child abuse may include any act or failure to act by a parent or other caregiver that results in actual or potential harm to a child, and can occur in a child's home or in the organizations, schools, or communities the child interacts with. This study was conducted to assess the primary health care (PHC) centers' physicians' knowledge and attitude toward child abuse including its types, and child neglect with their behavior regarding reporting of abuse cases. Methods: A cross-sectional study was conducted in Abha which is the capital of Aseer Province, including all PHC physicians (about 475) working in PHC centers. Data regarding physicians' demographic characteristics, perception, and awareness regarding child abuse and neglect were collected by self-administrative questionnaire in the PHC center during their time between patients' consultation. Results: The study included 300 PHC physicians whose ages ranged from 25 to 50 years old with mean age of 28 years. About 65% of the physicians were males and 69% of them were married with about 73% having at least one child. Overall, 96.3% of the physicians recorded good awareness level regarding types of child abuse and 97.3% recorded good awareness level regarding child neglect patterns. Underreporting of child abuse cases was recorded by about 64% of physicians. Conclusion: Regarding child abuse and neglect, PHC physicians have good knowledge, optimal attitude, and positive perception. There was also the problem of underreporting of suspected child abuse cases among PHC physicians in Saudi Arabia, with many barriers to report, such as community traditions; unclear reporting strategy was identified.

Background: Obesity-related morbidity continues to increase in Saudi Arabia, especially among school students, who constitute a vulnerable population since they can be highly influenced by the western culture and rapid globalization. Aim of Study: To examine the relationship between obesity and negative emotional states among male secondary school students. Methodology: This was a cross-sectional study conducted among male secondary school students in Abha City, Saudi Arabia during the academic year 2019-2020. A multistage cluster sampling technique was followed by the researchers, in order to recruit participants. The standardized Arabic version of Depression Anxiety Stress Scale (DASS-21) was used by the researchers for determining prevalence and levels of depression, anxiety and stress symptoms among participants. Results: Three hundred and ninety eight students participated in the study. Their mean age (±SD) was 16.98±0.93 years. Overweight and obesity was present among 44.2% and 38.4% of participants, respectively. The overall prevalence rates for symptoms of depression, anxiety and stress among participants were 57%, 64.6% and 39.4%, respectively. There were statistically significant associations between obesity and symptoms of depression, anxiety and stress (p

Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS) spectra, 1H nuclear magnetic resonance (NMR), 13C-NMR, and elemental analysis (CHN). The anticonvulsant activity was evaluated by a subcutaneous pentylenetetrazole (scPTZ) test and maximal electroshock (MES)-induced seizure test, while neurotoxicity was evaluated by a rotorod test. The molecular docking was performed for all newly-synthesized compounds to assess their binding affinities to the GABA-A receptor in order to rationalize their anticonvulsant activities in a qualitative way. The data obtained from the molecular modeling was correlated with that obtained from the biological screening. These data showed considerable anticonvulsant activity for all newly-synthesized compounds. Compounds 5b, 5c, and 5d showed the highest binding affinities toward the GABA-A receptor, along with the highest anticonvulsant activities in experimental mice. These compounds also showed low neurotoxicity and low toxicity in the median lethal dose test compared to the reference drugs. A GABA enzymatic assay was performed for these highly active compounds to confirm the obtained results and explain the possible mechanism for anticonvulsant action. The most active compounds might be used as leads for future modification and optimization.