1. The Free Alpha-Hemoglobin: A Promising Biomarker for β-Thalassemia
- Author
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Rosline Hassan, Nor Hedayah A Bakar, Alawiyah B A Abd Rahman, Iekhsan Othman, Atif Amin Baig, Hishamshah Ibrahim, Noraesah Mahmud, Zilfalil Alwi, Ahmed Gf Al-Attraqchi, and Uday Yh Abdullah
- Subjects
business.industry ,Thalassemia ,medicine ,Biomarker (medicine) ,Beta thalassemia ,In patient ,Alpha hemoglobin ,medicine.disease ,business ,Bioinformatics ,Omics ,Molecular biomarkers - Abstract
The purpose is to review the current knowledge and methods of determination of the free alpha hemoglobin with emphasis on its potential implications in patients with beta-thalassemia (β-thal).The severity of β-thal correlates with the extent of imbalance between α- and non-α-globin chains and the amount of the free alpha hemoglobin (free α- Hb) pool in the erythrocytes. To date, there is a lack of biomarkers that convey diagnostic and prognostic values in β-thal. Our ongoing research is aimed to evaluate the potential prognostic and diagnostic implications of free α-Hb to improve the care of patients with β-thal. Our ongoing research is aimed to quantify the free α-Hb for its potential prognostic and diagnosticimplications towards improving the care of patients with various β-thal types in the years to come.
- Published
- 2014
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