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16 results on '"Ahmed, Shahabuddin"'

8. Factors influencing patients’ satisfaction at different levels of health facilities in Bangladesh: Results from patient exit interviews

Author

Adhikary, Gourab, primary, Shawon, Md. Shajedur Rahman, additional, Ali, Md. Wazed, additional, Shamsuzzaman, Md., additional, Ahmed, Shahabuddin, additional, Shackelford, Katya A., additional, Woldeab, Alexander, additional, Alam, Nurul, additional, Lim, Stephen S., additional, Levine, Aubrey, additional, Gakidou, Emmanuela, additional, and Uddin, Md. Jasim, additional

Published
2018
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9. General service and child immunization-specific readiness assessment of healthcare facilities in two selected divisions in Bangladesh

Author

Shawon, Md. Shajedur Rahman, primary, Adhikary, Gourab, additional, Ali, Md. Wazed, additional, Shamsuzzaman, Md., additional, Ahmed, Shahabuddin, additional, Alam, Nurul, additional, Shackelford, Katya A., additional, Woldeab, Alexander, additional, Lim, Stephen S., additional, Levine, Aubrey, additional, Gakidou, Emmanuela, additional, and Uddin, Md. Jasim, additional

Published
2018
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15. Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches.

Author

Nazari, Kazem, Mehta, Prina, Arshad, Muhammad Sohail, Ahmed, Shahabuddin, Andriotis, Eleftherios G., Singh, Neenu, Qutachi, Omar, Chang, Ming-Wei, Fatouros, Dimitrios G., and Ahmad, Zeeshan

Subjects
HAZARD Analysis & Critical Control Point (Food safety system), FACTORIAL experiment designs, UNIVERSAL design, MANUFACTURING processes, ANTI-inflammatory agents, STATISTICAL software
Abstract

The purpose of this study was to apply the Quality by Design (QbD) approach to the electrospinning of fibres loaded with the nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin (INDO) and diclofenac sodium (DICLO). A Quality Target Product Profile (QTPP) was made, and risk assessments (preliminary hazard analysis) were conducted to identify the impact of material attributes and process parameters on the critical quality attributes (CQAs) of the fibres. A full factorial design of experiments (DoE) of 20 runs was built, which was used to carry out experiments. The following factors were assessed: Drugs, voltage, flow rate, and the distance between the processing needle and collector. Release studies exhibited INDO fibres had greater total release of active drug compared to DICLO fibres. Voltage and distance were found to be the most significant factors of the experiment. Multivariate statistical analytical software helped to build six feasible design spaces and two flexible, universal design spaces for both drugs, at distances of 5 cm and 12.5 cm, along with a flexible control strategy. The current findings and their analysis confirm that QbD is a viable and invaluable tool to enhance product and process understanding of electrospinning for the assurance of high-quality fibres. [ABSTRACT FROM AUTHOR]

Published
2020
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