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The synthesis of new NSAIDs with improved efficacy and selectivity towards COX2, which encouraged by 1,2,4-triazoles and 1,3,4-thiadiazoles with their various biological activities. In this experiment, the production of 1,2,4-triazolothiadiazoles derivatives from Ibuprofen. We have enhanced anti-inflammatory and analgesic activities by conventional method and microwave-assisted technique, and then compare the time consuming by reaction and yield percent of the product in both way, besides anti-inflammatory activity evaluation of targeted compounds by pharmacological test with predictable selectivity towards COX-2 enzyme. A successful synthesis of the target compounds has been achieved by checking purity, characterization, also identification of the synthetic compounds which detected by estimation of physical properties, FT-IR and 1H-NMR spectroscopy. The anti-inflammatory properties of the ending compounds in vivo are being evaluated using egg-white-induced edema models. The experienced compounds (1 MIC., 1 CON.) and the reference drug (Ibuprofen) produced significant reduction in paw edema in compare to the effect of control group. Wholly tested compounds produced considerable decrease of paw edema in contrast to control group. However, final synthesis compounds have considerable more paw edema declining than Ibuprofen. Intermediate and target compounds are synthesis by microwave method have better result by time, purity and yield in compare with conventional way. The synthesized compounds (1 or 2 or 3 MIC.,1 or 2 or 3 or CON.) may exhibit expected selectivity towards COX-2 enzyme properly due to their large size than its parent Ibuprofen. [ABSTRACT FROM AUTHOR]

New Schiff base ligand (N, O) and its complexes were synthesized by using condensation method. The ligand and its complexes C1, C2 and C3 have been identified by using techniques FT-IR spectroscopy, UV. Visible, 1H-NMR,13C-NMR, (CHN) analysis, atomic absorption, Mohr method and molar conductivity. The M(II) complexes had neutral nature and M (III) has been electrolyte behaviour based on molar conductivity. Octahedral structure has been proposed for all of complexes that have the bidentate ligand in metal: ligand mole ratio of (1:2). [ABSTRACT FROM AUTHOR]

Prodrug technique is used to remedy some troubles and enhance the interest of medication. Diclofenac is classified as non-steroidal and antiinflammatory drug (NSAIDS) which used as anti-inflammatory and analgesic however it has many side effects causing gastro-intestinal ulcer, gastro-esophageal reflex disease (GERD). Prodrug of diclofenac is synthesized by using coupling of amine with diclofenac and ester derivatives of amino acids production in the presence of HCl in dichloromethane. These newly synthesized prodrugs lower a number of the gastrointestinal adverse effects through covering the free carboxylic acid group to improve the bioavailability through reduction the hydrolysis by the effect of GIT enzymes. The prodrug is estimated for solubility and analyzed by using FTIR spectroscopy and nuclear magnetic resonance. [ABSTRACT FROM AUTHOR]

The seeds of phoenix dactylifera L. plants have many traditional uses of various kinds for disease, one folklore use of the oil of the plant seeds is the treatment of wound healing. this study undertaken the composition and content of certain bioactive constituents of the oil obtained from phoenix dactylifera L. seeds and the effect of the phoenix dactylifera L. seeds on wound healing in the rats. Uniform wounds were induced on the dorsum of 18 rats, randomly divided into three groups. The wounds were photographed, and topically treated with nothing (control group), 0.13 mg/mm2 of a reference drug ("Mebocream®"), and 0.52 µl/mm2 of phoenix dactylifera oil daily for 12 days and biopsies were histologically assessed. morphometric assessment and histological findings revealed healed biopsies from the plant oiltreated group of rats, unlike untreated group, and a full re-epithelialization with the reappearance of skin appendages and well organized collagen fibers without inflammatory cells. [ABSTRACT FROM AUTHOR]