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13. Oxidative stress-mediated epigenetic remodeling, metastatic progression and cell signaling in cancer.

Author

Phull, Abdul-Rehman, Arain, Sadia Qamar, Majid, Abdul, Fatima, Humaira, Ahmed, Madiha, and Kim, Song-Ja

Subjects
EPIGENOMICS, CELL communication, EPIGENETICS, RNA regulation, REACTIVE oxygen species, CANCER invasiveness
Abstract

Cancer is a serious public health issue and cases are rising at a high rate around the world. Altered production of reactive oxygen species (ROS) causes oxidative stress (OS) which plays a vital role in cancer development by disrupting signaling pathways and genomic integrity in the cellular microenvironment. In this study, we reviewed the regulation of noncoding RNAs, histone modifications, and DNA methylation which OS is involved in. These mechanisms promote cancer growth, metastasis, and resistance to chemotherapeutic agents. There is significant potential to improve patient outcomes through the development of customized medications and interventions that precisely address the role of OS in the onset and progression of cancer. Redox-modulating drugs, antioxidant-based therapies, and measures to restore regular cellular activity and OS-modulated signaling pathways are some examples of these strategies. One other hypothesis rationalizes the cancer-suppressing effect of OS, which acts as a two-edged condition that warns against the use of antioxidants for cancer treatment and management. The present study was executed to review the impact of OS on epigenetic machinery, the evolution of metastatic cancer, and how OS mediates cellular signaling. Along with, insights into the potential of targeting OS-mediated mechanisms for cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Help biocurators to maximize the reach of your data

Author

Holmes, Alexander, primary, Carvalho-Silva, Denise, additional, Sondka, Zbyslaw, additional, Ahmed, Madiha, additional, Argasinska, Joanna, additional, Lyne, Rachel, additional, Sangrador-Vegas, Amaia, additional, and Ward, Sari, additional

Published
2024
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17. Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer’s disease combined with insilico molecular docking

Author

Ismail, Hammad, primary, Khalid, Dania, additional, Waseem, Durdana, additional, Ijaz, Muhammad Umar, additional, Dilshad, Erum, additional, Haq, Ihsan-ul, additional, Bhatti, Muhammad Zeeshan, additional, Anwaar, Sadaf, additional, Ahmed, Madiha, additional, and Saleem, Samreen, additional

Published
2023
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21. COSMIC: a curated database of somatic variants and clinical data for cancer.

Author

Sondka, Zbyslaw, Dhir, Nidhi Bindal, Carvalho-Silva, Denise, Jupe, Steven, Madhumita, McLaren, Karen, Starkey, Mike, Ward, Sari, Wilding, Jennifer, Ahmed, Madiha, Argasinska, Joanna, Beare, David, Chawla, Manpreet Singh, Duke, Stephen, Fasanella, Ilaria, Neogi, Avirup Guha, Haller, Susan, Hetenyi, Balazs, Hodges, Leonie, and Holmes, Alex

Published
2024
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36. Effect of Tensile Frequency on the Osteogenic Differentiation of Periodontal Ligament Stem Cells

Author

Wang,Wenfang, Wang,Meijuan, Guo,Xiaomei, Zhao,Yunshan, Ahmed,Madiha Mohammed Saleh, Qi,Hong, Chen,Xi, Wang,Wenfang, Wang,Meijuan, Guo,Xiaomei, Zhao,Yunshan, Ahmed,Madiha Mohammed Saleh, Qi,Hong, and Chen,Xi

Abstract

Wenfang Wang,1,* Meijuan Wang,2,* Xiaomei Guo,3– 5 Yunshan Zhao,1 Madiha Mohammed Saleh Ahmed,1 Hong Qi,3– 5 Xi Chen1 1Department of Stomatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, 710000, People’s Republic of China; 2Anesthesiology Department, Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, 710000, People’s Republic of China; 3Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710000, People’s Republic of China; 4Laboratory Center of Stomatology, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710000, People’s Republic of China; 5Department of Pathology, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Qi, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, 98 Xiwu Road, Xi’an, 710000, People’s Republic of China, Tel +86-18161839153, Email qihong@mail.xjtu.edu.cn Xi Chen, Department of Stomatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, 227 West Yanta Road, Xi’an, 710000, People’s Republic of China, Tel +86-13038598996, Email 13038598996@163.comPurpose: The role of periodontal ligament stem cells (PDLSCs) in mediating osteogenesis involved in orthodontic tooth movement (OTM) is well established. However, various relevant in vitro studies vary in the frequency of tension. The effect of tensile frequency on the mechanotransduction of PDLSCs is not clear. The current study aimed to determine the effect of different tensile frequencies on the osteogenic differentiation of PDLSCs and to identify important mechano-sensitivity genes.Methods: Human PDLSCs were isolated, identified, and subjected to cyclic

Published
2022

37. FAM3B Serves as a Biomarker for the Development and Malignancy of Oral Lichen Planus

Author

Wang,Wenfang, Wang,Meijuan, Ahmed,Madiha Mohammed Saleh, Zhao,Yunshan, Wu,Hao, Musa,Mazen, Chen,Xi, Wang,Wenfang, Wang,Meijuan, Ahmed,Madiha Mohammed Saleh, Zhao,Yunshan, Wu,Hao, Musa,Mazen, and Chen,Xi

Abstract

Wenfang Wang,1 Meijuan Wang,2 Madiha Mohammed Saleh Ahmed,1 Yunshan Zhao,1 Hao Wu,1 Mazen Musa,1 Xi Chen1 1Department of Stomatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Anesthesiology Department, Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Xi Chen, Department of Stomatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, 227 West Yanta Road, Xi’an, 710000, People’s Republic of China, Tel +86-13038598996, Fax +86-2985252580, Email 13038598996@163.comPurpose: Oral lichen planus (OLP) is a potentially malignant condition with unclear etiology. This study aimed to identify potential biomarkers and mechanisms for OLP progression through bioinformatics analyses.Methods: Gene Expression Omnibus (GEO) datasets were screened to identify differentially expressed genes (DEGs) between OLP patients and healthy individuals. The functions and enriched pathways of the DEGs were identified. Sequencing dataset GSE70665 was then used to analyze the role of DEGs in the development of OLP to oral squamous cell carcinoma (OSCC). Oncomine and The Cancer Genome Atlas (TCGA) databases were utilized to evaluate clinicopathological characters of OSCC. Univariate and multivariate Cox regression models were used to identify independent prognostic factors.Results: A total of 24 DEGs were identified between OLP and normal samples. FAM3B was under-expressed in OLP compared with normal samples and was further significantly downregulated in OSCC compared with OLP. Under-expression of FAM3B was significantly correlated with tumor stage and disease-specific survival (DSS), progression-free interval (PFI) and overall survival (OS) of OSCC patients. With univariate and multivariate Cox regression analysis

Published
2022

41. FAM3B Serves as a Biomarker for the Development and Malignancy of Oral Lichen Planus

Author

Wang, Wenfang, Wang, Meijuan, Ahmed, Madiha Mohammed Saleh, Zhao, Yunshan, Wu, Hao, Musa, Mazen, and Chen, Xi

Subjects
oral squamous cell carcinoma, stomatognathic diseases, potentially malignant condition, stomatognathic system, International Journal of General Medicine, bioinformatics, prognosis, General Medicine, Original Research
Abstract

Wenfang Wang,1 Meijuan Wang,2 Madiha Mohammed Saleh Ahmed,1 Yunshan Zhao,1 Hao Wu,1 Mazen Musa,1 Xi Chen1 1Department of Stomatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Anesthesiology Department, Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Xi Chen,Department of Stomatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, 227 West Yanta Road, Xi’an, 710000, People’s Republic of China, Tel +86-13038598996, Fax +86-2985252580, Email 13038598996@163.comPurpose: Oral lichen planus (OLP) is a potentially malignant condition with unclear etiology. This study aimed to identify potential biomarkers and mechanisms for OLP progression through bioinformatics analyses.Methods: Gene Expression Omnibus (GEO) datasets were screened to identify differentially expressed genes (DEGs) between OLP patients and healthy individuals. The functions and enriched pathways of the DEGs were identified. Sequencing dataset GSE70665 was then used to analyze the role of DEGs in the development of OLP to oral squamous cell carcinoma (OSCC). Oncomine and The Cancer Genome Atlas (TCGA) databases were utilized to evaluate clinicopathological characters of OSCC. Univariate and multivariate Cox regression models were used to identify independent prognostic factors.Results: A total of 24 DEGs were identified between OLP and normal samples. FAM3B was under-expressed in OLP compared with normal samples and was further significantly downregulated in OSCC compared with OLP. Under-expression of FAM3B was significantly correlated with tumor stage and disease-specific survival (DSS), progression-free interval (PFI) and overall survival (OS) of OSCC patients. With univariate and multivariate Cox regression analysis, FAM3B was an independent prognostic factor.Conclusion: Under-expression of FAM3B was associated with the development and malignancy of OLP. FAM3B may serve as a potential prognostic biomarker for OLP.Keywords: bioinformatics, potentially malignant condition, oral squamous cell carcinoma, prognosis

Published
2022

50. Preventing Catheter Related Bladder Discomfort (CRBD) in male patients undergoing lower urinary tract surgery with bilateral Pudendal Nerve Block: a Randomized Controlled Trial.

Author

Yasrab, Mohammad, Naqvi, Syed Ehtesham Haider, Ahmed, Fariha, Ahmed, Madiha, Rana, Sumbal, and Khushdil, Arshad

Subjects
PUDENDAL nerve, URINARY organs, RANDOMIZED controlled trials, NERVE block, TRANSURETHRAL prostatectomy, BLADDER
Abstract

Objective: To compare the frequency and severity of post-operative CRBD in patients undergoing TURP and TURBT with spinal anaesthesia with pudendal nerve block against spinal anaesthesia alone. Study Design: A randomized controlled trial (Clinical trials.gov: NCT05022160) Place and Duration of Study: Armed Forces Institute of Urology (AFIU), Rawalpindi Pakistan, from Aug to Nov, 2021. Methodology: The trial comprised 250 patients scheduled to have a transurethral resection of the prostate (TURP) or a transurethral resection of a bladder tumour (TURBT) under spinal anaesthesia. They were split into two groups: study (group-P) and control (group-C). After surgery, the patients in the study-group were given a bilateral pudendal nerve block. At 3, 8, 12, and 24 hours following surgery, the frequency and severity of catheter-related bladder discomfort (CRBD) were documented. Results: CRBD frequencies were significantly lower in pudendal group at 3 hours 42 (33.8%) vs 72 (58.5%), p <0.001), 8 hours 81 (65.3%) vs 111 (90.2%), p<0.001 and 12 hours 53 (42.7%) vs 73 (59.3%), p=0.009 after the surgery. The postoperative pain score in pudendal group was lower at 3 hours (p<0.001), 8 hours (p <0.001), and 12 hours (p=0.02) but there was no statistically significant difference between the two groups at 24 hours (p=0.06). Conclusion: When used in conjunction with spinal anaesthesia, a pudendal nerve block reduces the frequency and severity of catheter-related bladder discomfort for up to 12 hours after surgery. [ABSTRACT FROM AUTHOR]

Published
2022
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