Search

Your search keyword '"Ahmed, Kumail"' showing total 38 results
Start Over Author "Ahmed, Kumail"
38 results on '"Ahmed, Kumail"'

1. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Ashraful, Nahar Begum, SM Khodeza, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Hasan, Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jamil, Zehra, Kabir, Furqan, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Tarr, Phillip I, Tearney, Guillermo J, Umrani, Fayaz, Umutesi, Grace, Yilmaz, Omer H, Ehsan, Lubaina, Coomes, David, Kelly, Paul, Greene, Adam R, Ali, S Asad, Mulenga, Chola, Denno, Donna M, VanBuskirk, Kelley, Raghib, Muhammad Faraz, Mahfuz, Mustafa, Moore, Sean R, Hossain, Md Shabab, Ahmed, Tahmeed, Sullivan, Peter B, Moskaluk, Christopher A, and Syed, Sana

Published
2024
Full Text
View/download PDF

2. Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J, Marie, Chelsea, Mazumder, Ramendra Nath, Mudenda, Victor, Mulenga, Chola, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, VanBuskirk, Kelley, Mweetwa, Monica, Kolterman, Tad, Raghavan, Shyam, Ahmed, Tahmeed, Ali, S Asad, Nahar Begum, SM Khodeza, Besa, Ellen, Denno, Donna M, Jamil, Zehra, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Mouksassi, Samer, Petri, William A, Jr., Tarr, Phillip I, Sullivan, Peter B, and Moskaluk, Christopher A

Published
2024
Full Text
View/download PDF

3. Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a multicountry cohort study

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Ali, S. Asad, Amadi, Beatrice, Das, Subhasish, Gazi, Md. Amran, Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Raghavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa, Iqbal, Najeeha T, Lawrence, Sarah, Ahmed, Tahmeed, Chandwe, Kanta, Fahim, Shah M, Houpt, Eric R, Kabir, Furqan, Kelly, Paul, Liu, Jie, Mahfuz, Mustafa, Mweetwa, Monica, VanBuskirk, Kelley, Tarr, Phillip I, and Denno, Donna M

Published
2024
Full Text
View/download PDF

4. Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study

Author

Ahmed, Kumail, Ahmed, Sheraz, Ahmed, Tahmeed, Alam, Md. Ashraful, Amadi, Beatrice, Begum, S.M. Khodeza Nahar, Besa, Ellen, Fahim, Shah Mohammad, Gazi, Md. Amran, Gilchrist, Carol A., Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., Zyambo, Kanekwa, Mahfuz, Mustafa, Coomes, David, Abdalla, Marwa, Mweetwa, Monica, VanBuskirk, Kelley, Iqbal, Najeeha T, Ali, S Asad, Chandwe, Kanta, Das, Subhasish, Kelly, Paul, Shaikh, Nurmohammad, Tarr, Phillip I, and Denno, Donna M

Published
2024
Full Text
View/download PDF

5. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Begum, S.M. Khodeza Nahar, Besa, Ellen, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A., Fahim, Shah Mohammad, Gazi, Md. Amran, Hasan, Md. Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Lawrence, Sarah, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Morgan, Brooks, Mudenda, Victor, Mulenga, Chola, Mweetwa, Monica, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, Zyambo, Kanekwa, Kelly, Paul, VanBuskirk, Kelley, Coomes, David, Mouksassi, Samer, Smith, Gerald, Jamil, Zehra, Hossain, Md Shabab, Syed, Sana, Marie, Chelsea, Tarr, Phillip I, Sullivan, Peter B, Petri, William A, Jr, Denno, Donna M, Ahmed, Tahmeed, Mahfuz, Mustafa, Ali, S Asad, Moore, Sean R, Ndao, I Malick, Tearney, Guillermo J, Ömer H Yilmaz, Raghavan, Shyam S, Moskaluk, Christopher A, and Liu, Ta-Chiang

Published
2024
Full Text
View/download PDF

6. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa, Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Jr., Tarr, Phillip I, and Denson, Lee A

Published
2024
Full Text
View/download PDF

7. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Jr., and Ali, S Asad

Published
2024
Full Text
View/download PDF

8. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction

Author

Ahmed, Kumail, Alam, Md Ashraful, Barnes, Barrett H, Begum, SM Khodeza Nahar, Borowitz, Stephen M, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A, Donowitz, Jeffrey R, Fahim, Shah Mohammad, Gazi, Md Amran, Gilchrist, Carol A, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Mann, Barbara J, Mazumder, Ramendra Nath, Memon, Waheeda, Middleton, Jeremy P, Nayak, Uma, Oliphant, Sandra, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Ramakrishnan, Girija, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, Denno, Donna M, Ahmed, Sheraz, Ahmed, Tahmeed, Ali, S Asad, Amadi, Beatrice, Kelly, Paul, Lawrence, Sarah, Mahfuz, Mustafa, Marie, Chelsea, Moore, Sean R, Nataro, James P, Petri, William A, Jr, Sullivan, Peter B, and Tarr, Phillip I

Published
2024
Full Text
View/download PDF

9. Humoral and T cell responses to SARS-CoV-2 reveal insights into immunity during the early pandemic period in Pakistan

Author

Masood, Kiran Iqbal, Qaiser, Shama, Abidi, Syed Hani, Khan, Erum, Mahmood, Syed Faisal, Hussain, Areeba, Ghous, Zara, Imtiaz, Khekahsan, Ali, Natasha, Hasan, Muhammad, Memon, Haris Ali, Yameen, Maliha, Ali, Shiza, Baloch, Sadaf, Lakhani, Gulzar, Alves, Paula M., Iqbal, Najeeha Talat, Ahmed, Kumail, Iqbal, Junaid, Bhutta, Zulfiqar A., Hussain, Rabia, Rottenberg, Martin, Simas, J. Pedro, Veldhoen, Marc, Ghias, Kulsoom, and Hasan, Zahra

Published
2023
Full Text
View/download PDF

10. A shared group of bacterial taxa in the duodenal microbiota of undernourished Pakistani children with environmental enteric dysfunction

Author

Iqbal, Najeeha T., primary, Chen, Robert Y., additional, Griffin, Nicholas W., additional, Hibberd, Matthew C., additional, Khalid, Aqsa, additional, Sadiq, Kamran, additional, Jamil, Zehra, additional, Ahmed, Kumail, additional, Iqbal, Junaid, additional, Hotwani, Aneeta, additional, Kabir, Furqan, additional, Rahman, Najeeb, additional, Rizvi, Arjumand, additional, Idress, Romana, additional, Ahmed, Zubair, additional, Ahmed, Sheraz, additional, Umrani, Fayaz, additional, Syed, Sana, additional, Moore, Sean R., additional, Ali, Asad, additional, Barratt, Michael J., additional, and Gordon, Jeffrey I., additional

Published
2024
Full Text
View/download PDF

12. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multi-country analysis

Author

Ehsan, Lubaina, primary, Coomes, David, additional, Kelly, Paul, additional, Greene, Adam R., additional, Ali, S. Asad, additional, Mulenga, Chola, additional, Denno, Donna M., additional, VanBuskirk, Kelley, additional, Raghib, Muhammad Faraz, additional, Mahfuz, Mustafa, additional, Moore, Sean R., additional, Hossain, M. Shabab, additional, Ahmed, Tahmeed, additional, Sullivan, Peter B., additional, Moskaluk, Christopher A., additional, Syed, Sana, additional, Ahmed, Kumail, additional, Ahmed, Sheraz, additional, Alam, Md. Ashraful, additional, Begum, S.M. Khodeza Nahar, additional, Das, Subhasish, additional, Denson, Lee A., additional, Fahim, Shah Mohammad, additional, Gazi, Md. Amran, additional, Hasan, Md. Mehedi, additional, Hotwani, Aneeta, additional, Iqbal, Junaid, additional, Jamil, Zehra, additional, Kabir, Furqan, additional, Liu, Ta-Chiang, additional, Mazumder, Ramendra Nath, additional, Ragahavan, Shyam S., additional, Rahman, Masudur, additional, Rahman, Najeeb, additional, Sadiq, Kamran, additional, Sarker, Shafiqul Alam, additional, Tarr, Phillip I., additional, Tearney, Guillermo J., additional, Umrani, Fayaz, additional, Umutesi, Grace, additional, and Yilmaz, Omer H., additional

Published
2024
Full Text
View/download PDF

13. Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction

Author

VanBuskirk, Kelley, Mweetwa, Monica, Kolterman, Tad, Raghavan, Shyam, Ahmed, Tahmeed, Ali, S Asad, Nahar Begum, SM Khodeza, Besa, Ellen, Denno, Donna M, Jamil, Zehra, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Mouksassi, Samer, Petri, William A, Tarr, Phillip I, Sullivan, Peter B, Moskaluk, Christopher A, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J, Marie, Chelsea, Mazumder, Ramendra Nath, Mudenda, Victor, Mulenga, Chola, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Tearney, Guillermo J, Umrani, Fayaz, and Yilmaz, Omer H

Abstract

Environmental enteric dysfunction (EED) is characterized by reduced absorptive capacity and barrier function of the small intestine, leading to poor ponderal and linear childhood growth.

Published
2024
Full Text
View/download PDF

14. Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a multicountry cohort study

Author

Iqbal, Najeeha T, Lawrence, Sarah, Ahmed, Tahmeed, Chandwe, Kanta, Fahim, Shah M, Houpt, Eric R, Kabir, Furqan, Kelly, Paul, Liu, Jie, Mahfuz, Mustafa, Mweetwa, Monica, VanBuskirk, Kelley, Tarr, Phillip I, Denno, Donna M, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Ali, S. Asad, Amadi, Beatrice, Das, Subhasish, Gazi, Md. Amran, Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Raghavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, and Zyambo, Kanekwa

Abstract

Environmental Enteric Dysfunction (EED) is an acquired disorder of asymptomatic altered gut function, the etiology of which is unknown. EED is postulated to be a major contributor to growth faltering in early childhood in regions where early-life enteropathogenic carriage is prevalent. Few studies have examined the critical organ (the upper small bowel) with enteropathogens in the evolution of small bowel disease.

Published
2024
Full Text
View/download PDF

15. Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study

Author

Mahfuz, Mustafa, Coomes, David, Abdalla, Marwa, Mweetwa, Monica, VanBuskirk, Kelley, Iqbal, Najeeha T, Ali, S Asad, Chandwe, Kanta, Das, Subhasish, Kelly, Paul, Shaikh, Nurmohammad, Tarr, Phillip I, Denno, Donna M, Ahmed, Kumail, Ahmed, Sheraz, Ahmed, Tahmeed, Alam, Md. Ashraful, Amadi, Beatrice, Begum, S.M. Khodeza Nahar, Besa, Ellen, Fahim, Shah Mohammad, Gazi, Md. Amran, Gilchrist, Carol A., Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., and Zyambo, Kanekwa

Abstract

Validated biomarkers could catalyze environmental enteric dysfunction (EED) research.

Published
2024
Full Text
View/download PDF

16. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children

Author

Kelly, Paul, VanBuskirk, Kelley, Coomes, David, Mouksassi, Samer, Smith, Gerald, Jamil, Zehra, Hossain, Md Shabab, Syed, Sana, Marie, Chelsea, Tarr, Phillip I, Sullivan, Peter B, Petri, William A, Denno, Donna M, Ahmed, Tahmeed, Mahfuz, Mustafa, Ali, S Asad, Moore, Sean R, Ndao, I Malick, Tearney, Guillermo J, Yilmaz, Ömer H, Raghavan, Shyam S, Moskaluk, Christopher A, Liu, Ta-Chiang, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Begum, S.M. Khodeza Nahar, Besa, Ellen, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A., Fahim, Shah Mohammad, Gazi, Md. Amran, Hasan, Md. Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Lawrence, Sarah, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Morgan, Brooks, Mudenda, Victor, Mulenga, Chola, Mweetwa, Monica, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, and Zyambo, Kanekwa

Abstract

Environmental enteric dysfunction (EED) is an asymptomatic intestinal disorder associated with growth impairment, delayed neurocognitive development, and impaired oral vaccine responses.

Published
2024
Full Text
View/download PDF

17. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Author

Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Tarr, Phillip I, Denson, Lee A, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, and Zyambo, Kanekwa

Abstract

Environmental enteric dysfunction (EED) is an inflammatory condition of the small intestine that is prevalent in children residing in low- and middle-income countries. EED is accompanied by profound histopathologic changes in the small bowel, loss of absorptive capacity, increased intestinal permeability, increased microbial translocation, and nutrient loss.

Published
2024
Full Text
View/download PDF

18. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction

Author

Denno, Donna M, Ahmed, Sheraz, Ahmed, Tahmeed, Ali, S Asad, Amadi, Beatrice, Kelly, Paul, Lawrence, Sarah, Mahfuz, Mustafa, Marie, Chelsea, Moore, Sean R, Nataro, James P, Petri, William A, Sullivan, Peter B, Tarr, Phillip I, Ahmed, Kumail, Alam, Md Ashraful, Barnes, Barrett H, Begum, SM Khodeza Nahar, Borowitz, Stephen M, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A, Donowitz, Jeffrey R, Fahim, Shah Mohammad, Gazi, Md Amran, Gilchrist, Carol A, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Mann, Barbara J, Mazumder, Ramendra Nath, Memon, Waheeda, Middleton, Jeremy P, Nayak, Uma, Oliphant, Sandra, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Ramakrishnan, Girija, Sadiq, Kamran, Sarker, Shafiqul Alam, and Umrani, Fayaz

Abstract

Environmental enteric dysfunction (EED) is an asymptomatic acquired disorder characterized by upper small bowel inflammation, villus blunting, and gut permeability. It is a major contributor to poor growth in childhood as well as other highly consequential outcomes such as delayed neuorcognitive development. After decades of intermittent interest in this entity, we are now seeing a resurgence in the field of EED. However, recent studies have been hampered by a lack of investigation of the target tissue—the upper small bowel. In 2016, the EEDBI (Environmental Enteric Dysfunction Biopsy Initiative) Consortium was established as a common scientific platform across 3 independent EED biopsy cohort studies in Bangladesh, Pakistan, and Zambia. Two centers in the United States recruited comparison groups of children undergoing endoscopy for clinical indications. The EEDBI Consortium goal was to augment the contributions of the individual centers and answer high-level questions amenable to analysis and interpretation across the studies. Here, we describe the Consortium and its cohorts and recruitment procedures across studies. We also offer details applicable to all papers in this supplement, which describe EED mucosal histology, morphometry, immunohistochemistry, and transcriptomics as well as histology relationship to pathogens and biomarkers.

Published
2024
Full Text
View/download PDF

19. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Author

Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Ali, S Asad, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, and Yilmaz, Omer H.

Abstract

Environmental enteric dysfunction (EED) is a precursor of growth faltering in children living in impoverished conditions who are frequently exposed to environmental toxins and enteropathogens, leading to small bowel inflammatory, malabsorptive, and permeability derangements and low-grade chronic systemic inflammation.

Published
2024
Full Text
View/download PDF

20. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis

Author

Ehsan, Lubaina, Coomes, David, Kelly, Paul, Greene, Adam R, Ali, S Asad, Mulenga, Chola, Denno, Donna M, VanBuskirk, Kelley, Raghib, Muhammad Faraz, Mahfuz, Mustafa, Moore, Sean R, Hossain, Md Shabab, Ahmed, Tahmeed, Sullivan, Peter B, Moskaluk, Christopher A, Syed, Sana, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Begum, SM Khodeza Nahar, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Hasan, Md Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jamil, Zehra, Kabir, Furqan, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Tarr, Phillip I, Tearney, Guillermo J, Umrani, Fayaz, Umutesi, Grace, and Yilmaz, Omer H

Abstract

Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver of childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration of its association with functional and disease outcomes.

Published
2024
Full Text
View/download PDF

22. SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

Author

Bowen, John E., primary, Park, Young-Jun, additional, Stewart, Cameron, additional, Brown, Jack T., additional, Sharkey, William K., additional, Walls, Alexandra C., additional, Joshi, Anshu, additional, Sprouse, Kaitlin R., additional, McCallum, Matthew, additional, Tortorici, M. Alejandra, additional, Franko, Nicholas M., additional, Logue, Jennifer K., additional, Mazzitelli, Ignacio G., additional, Nguyen, Annalee W., additional, Silva, Rui P., additional, Huang, Yimin, additional, Low, Jun Siong, additional, Jerak, Josipa, additional, Tiles, Sasha W., additional, Ahmed, Kumail, additional, Shariq, Asefa, additional, Dan, Jennifer M., additional, Zhang, Zeli, additional, Weiskopf, Daniela, additional, Sette, Alessandro, additional, Snell, Gyorgy, additional, Posavad, Christine M., additional, Iqbal, Najeeha Talat, additional, Geffner, Jorge, additional, Bandera, Alessandra, additional, Gori, Andrea, additional, Sallusto, Federica, additional, Maynard, Jennifer A., additional, Crotty, Shane, additional, Van Voorhis, Wesley C., additional, Simmerling, Carlos, additional, Grifantini, Renata, additional, Chu, Helen Y., additional, Corti, Davide, additional, and Veesler, David, additional

Published
2022
Full Text
View/download PDF

23. Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

Author

Bowen, John E., primary, Addetia, Amin, additional, Dang, Ha V., additional, Stewart, Cameron, additional, Brown, Jack T., additional, Sharkey, William K., additional, Sprouse, Kaitlin R., additional, Walls, Alexandra C., additional, Mazzitelli, Ignacio G., additional, Logue, Jennifer K., additional, Franko, Nicholas M., additional, Czudnochowski, Nadine, additional, Powell, Abigail E., additional, Dellota, Exequiel, additional, Ahmed, Kumail, additional, Ansari, Asefa Shariq, additional, Cameroni, Elisabetta, additional, Gori, Andrea, additional, Bandera, Alessandra, additional, Posavad, Christine M., additional, Dan, Jennifer M., additional, Zhang, Zeli, additional, Weiskopf, Daniela, additional, Sette, Alessandro, additional, Crotty, Shane, additional, Iqbal, Najeeha Talat, additional, Corti, Davide, additional, Geffner, Jorge, additional, Snell, Gyorgy, additional, Grifantini, Renata, additional, Chu, Helen Y., additional, and Veesler, David, additional

Published
2022
Full Text
View/download PDF

26. Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines

Author

Bowen, John E., primary, Sprouse, Kaitlin R., additional, Walls, Alexandra C., additional, Mazzitelli, Ignacio G., additional, Logue, Jennifer K., additional, Franko, Nicholas M., additional, Ahmed, Kumail, additional, Shariq, Asefa, additional, Cameroni, Elisabetta, additional, Gori, Andrea, additional, Bandera, Alessandra, additional, Posavad, Christine M., additional, Dan, Jennifer M., additional, Zhang, Zeli, additional, Weiskopf, Daniela, additional, Sette, Alessandro, additional, Crotty, Shane, additional, Iqbal, Najeeha Talat, additional, Corti, Davide, additional, Geffner, Jorge, additional, Grifantini, Renata, additional, Chu, Helen Y., additional, and Veesler, David, additional

Published
2022
Full Text
View/download PDF

27. Dynamics of IgG Antibody Responses to SARS-CoV-2 Reveals Insight into Immunity During the Early Pandemic Period in Pakistan

Author

Masood, Kiran Iqbal, primary, Qaiser, Shama, additional, Abidi, Syed, additional, Khan, Erum, additional, Mahmood, Syed Faisal, additional, Hussain, Areeba, additional, Ghous, Zara, additional, Imtiaz, Kehkashan, additional, Ali, Natasha, additional, Hayat, Hassan, additional, Memon, Haris Ali, additional, Yameen, Maliha, additional, Ali, Shiza, additional, Lakhani, Gulzar, additional, Baloch, Sadaf, additional, Alves, Paula, additional, Iqbal, Najeeha Talat, additional, Ahmed, Kumail, additional, Mehmood, Junaid, additional, Bhutta, Zulfiqar A, additional, Hussain, Rabia, additional, Rottenberg, Martin, additional, Simas, J. Pedro, additional, Veldhoen, Marc, additional, Ghias, Kulsoom, additional, and Hasan, Zahra, additional

Published
2022
Full Text
View/download PDF

28. SARS-CoV-2 spike conformation determines plasma neutralizing activity

Author

Bowen, John E., primary, Walls, Alexandra C., additional, Joshi, Anshu, additional, Sprouse, Kaitlin R., additional, Stewart, Cameron, additional, Tortorici, M. Alejandra, additional, Franko, Nicholas M., additional, Logue, Jennifer K., additional, Mazzitelli, Ignacio G., additional, Tiles, Sasha W, additional, Ahmed, Kumail, additional, Shariq, Asefa, additional, Snell, Gyorgy, additional, Iqbal, Najeeha Talat, additional, Geffner, Jorge, additional, Bandera, Alessandra, additional, Gori, Andrea, additional, Grifantini, Renata, additional, Chu, Helen Y., additional, Van Voorhis, Wesley C., additional, Corti, Davide, additional, and Veesler, David, additional

Published
2021
Full Text
View/download PDF

29. Gut integrity and duodenal enteropathogen burden in undernourished children with environmental enteric dysfunction

Author

Jamil, Zehra, primary, Iqbal, Najeeha Talat, additional, Idress, Romana, additional, Ahmed, Zubair, additional, Sadiq, Kamran, additional, Mallawaarachchi, Indika, additional, Iqbal, Junaid, additional, Syed, Sana, additional, Hotwani, Aneeta, additional, Kabir, Furqan, additional, Ahmed, Kumail, additional, Ahmed, Sheraz, additional, Umrani, Fayaz, additional, Ma, Jennie Z., additional, Aziz, Fatima, additional, Kalam, Adil, additional, Moore, Sean R., additional, and Ali, Syed Asad, additional

Published
2021
Full Text
View/download PDF

30. Mo1173 TRANSNASAL ENDOMICROSCOPY FOR UNSEDATED OCT IMAGING OF THE UPPER GASTROINTESTINAL TRACT IN INFANTS

Author

Shore, Rachel E., primary, Grant, Catriona N., additional, Farrokhi, Hamid, additional, Dong, Jing, additional, Otuya, David, additional, Kumar, Aditya, additional, Zemlok, Sarah K., additional, Choy, Peter, additional, Schellenberg, Mason, additional, Beatty, Matthew, additional, Grahmann, Patricia, additional, Bablouzian, Ara, additional, Vuong, Barry, additional, Giddings, Sarah, additional, Bhat, Nitasha Gajanthodi Mudalaje, additional, Rosenberg, Mireille, additional, Leon, Paola, additional, Farewell, Edward, additional, Ali, Asad, additional, Sadiq, Kamran, additional, Ahmed, Kumail, additional, Mushtaq, Dania, additional, Umrani, Fayaz A., additional, Rani, Seema, additional, and Tearney, Guillermo, additional

Published
2020
Full Text
View/download PDF

31. Antibody-Secreting Cells To Diagnose Mycobacterium tuberculosis Infection in Children in Pakistan

Author

Iqbal, Najeeha Talat, primary, Ahmed, Kumail, additional, Qamar, Farah N., additional, Shaheen, Fariha, additional, Mehnaz, Aisha, additional, Arif, Fehmina, additional, Saeed, Amna Afzal, additional, Yousuf, Aneeq Muhammad, additional, Raza, Syeda Fatima, additional, Sultana, Shazia, additional, Qureshi, Shahida Mumtaz, additional, Siddiqi, Shakil Ahmad, additional, Houpt, Eric, additional, and Thomas, Tania, additional

Published
2020
Full Text
View/download PDF

32. Tu1594 – Tethered Capsule Oct Imaging of the Duodenum in Adolescents in Pakistan

Author

Bhat, Nitasha Gajanthodi Mudalaje, primary, Dong, Jing, additional, Sadiq, Kamran, additional, Vuong, Barry, additional, Grant, Catriona N., additional, Lerman, Irene, additional, Shakil, Omair, additional, Gao, Anna H., additional, Farrokhi, Hamid, additional, Giddings, Sarah, additional, Ahmed, Kumail, additional, Rani, Seema, additional, Rosenberg, Mireille, additional, Fasano, Alessio, additional, Damman, Christopher, additional, Ali, Asad, additional, and Tearney, Guillermo, additional

Published
2019
Full Text
View/download PDF

33. Duodenal imaging by tethered capsule OCT endomicroscopy in adolescents with environmental enteric dysfunction (Conference Presentation)

Author

Dong, Jing, primary, Sadiq, Kamran, additional, Grant, Catriona N., additional, Shakil, Omair, additional, Otuya, David O., additional, Farrokhi, Hamid, additional, Gao, Anna, additional, Bhat, Nitasha G. M., additional, Giddings, Sarah L., additional, Ahmed, Kumail, additional, Rani, Seema, additional, Rosenberg, Mireille, additional, Fasano, Alessio, additional, Damman, Christopher J., additional, Ali, Asad, additional, and Tearney, Guillermo J., additional

Published
2019
Full Text
View/download PDF

35. Effect of Vitamin D Supplementation on the Salivary Cytokines of Pregnant Women: A Randomized Placebo-Controlled Trial.

Author

Khan, Farhan Raza, Iqbal, Najeeha Talat, Ahmed, Kumail, Ahmad, Tashfeen, Hussain, Rabia, and Bhutta, Zulfiqar Ahmed

Abstract

Objective: We aimed to determine the salivary cytokine profiles of IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17 among pregnant women and determine if the cytokine profiles change upon administration of vitamin D to these women.Methods: It was a community-based, blinded, placebo-controlled, randomized trial. The intervention group comprised pregnant females (n = 36) who received oral vitamin D 4000 IU/day for 6 months (starting from 12 - 16 weeks until the end of pregnancy). Controls comprised pregnant females who received placebo (n = 49) for the same duration. Probing depth (PD), attachment loss (AL) and bleeding on probing (BOP) were recorded. Saliva samples were subjected to multiplex ELISA analysis of cytokines. Serum vitamin D levels were determined. Outcome was assessed within 14 days post-partum. Periodontal examinations were done; blood and saliva samples were subjected to the set of tests described at baseline. SPSS 19.0 and Graph Pad 6.0 were used for analysis. The study was registered at www.clinicaltrials.gov with identifier number NCT01422122.Results: The two study groups were comparable at the baseline. Although IL-6 showed wide variation, none of the pro-inflammatory cytokine levels was affected by six months of oral vitamin D supplementation. Similarly, the mean salivary levels of the anti-inflammatory cytokines IL-4 and IL-10 also remained unaffected in the two groups.Conclusion: There was no association between hypovitaminosis D and periodontal disease among the studied sample of pregnant women. None of the salivary cytokines showed any significant change after six months of oral vitamin D supplementation to the pregnant women. [ABSTRACT FROM AUTHOR]

Published
2017

36. Host-microbiome determinants of ready-to-use supplemental food efficacy in acute childhood malnutrition.

Author

Jamil Z, Hanson GF, Iqbal J, Moreau GB, Iqbal NT, Ahmed S, Hotwani A, Kabir F, Umrani F, Sadiq K, Ahmed K, Mallawaarachchi I, Ma JZ, Aziz F, Ali SA, and Moore S

Abstract

Ready-to-use supplemental foods (RUSF) are energy-dense meals formulated to prevent and treat moderate and severe childhood acute malnutrition (MAM and SAM) in high-risk settings. Although lifesaving, the degree and durability of weight recovery with RUSF is unpredictable. We examined whether environmental enteric dysfunction (EED) and gut microbiota perturbations are risk factors for RUSF failure in a birth cohort of 416 rural Pakistani children followed for growth, common childhood illnesses, and biomarkers from blood, urine, and stool. Infants who developed wasting (weight-for-length Z score <-2, n=187, 45%) during surveillance received Acha Mum (a chickpea-based RUSF) daily for eight weeks. Machine learning identified seven biomarkers that predicted RUSF response (n=75) vs. non-response (n=112) with 73% accuracy. Remarkably, gut microbiome composition predicted RUSF response with 93% (pre-supplementation) and 98% (post-supplementation) accuracy. Seven outliers whose microbiome falsely predicted positive response experienced extraordinary burdens of inflammation and illness during supplementation. These findings identify gut microbial signatures and biomarkers of gut and systemic inflammation as robust predictors of RUSF response in infants free from intercurrent illness during recovery, setting the stage for predictive models to guide precision use of RUSF and adjunct therapies in undernourished children.

Published
2024
Full Text
View/download PDF

37. Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines.

Author

Bowen JE, Sprouse KR, Walls AC, Mazzitelli IG, Logue JK, Franko NM, Ahmed K, Shariq A, Cameroni E, Gori A, Bandera A, Posavad CM, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Iqbal NT, Corti D, Geffner J, Grifantini R, Chu HY, and Veesler D

Abstract

The SARS-CoV-2 Omicron variant of concern comprises three sublineages designated BA.1, BA.2, and BA.3, with BA.2 steadily replacing the globally dominant BA.1. We show that the large number of BA.1 and BA.2 spike mutations severely dampen plasma neutralizing activity elicited by infection or seven clinical vaccines, with cross-neutralization of BA.2 being consistently more potent than that of BA.1, independent of the vaccine platform and number of doses. Although mRNA vaccines induced the greatest magnitude of Omicron BA.1 and BA.2 plasma neutralizing activity, administration of a booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1 and BA.2 across all vaccines evaluated. Our data suggest that although BA.1 and BA.2 evade polyclonal neutralizing antibody responses, current vaccine boosting regimens may provide sufficient protection against Omicron-induced disease.

Published
2022
Full Text
View/download PDF

38. SARS-CoV-2 spike conformation determines plasma neutralizing activity.

Author

Bowen JE, Walls AC, Joshi A, Sprouse KR, Stewart C, Tortorici MA, Franko NM, Logue JK, Mazzitelli IG, Tiles SW, Ahmed K, Shariq A, Snell G, Iqbal NT, Geffner J, Bandera A, Gori A, Grifantini R, Chu HY, Van Voorhis WC, Corti D, and Veesler D

Abstract

Numerous safe and effective COVID-19 vaccines have been developed that utilize various delivery technologies and engineering strategies. The influence of the SARS-CoV-2 spike (S) glycoprotein conformation on antibody responses induced by vaccination or infection in humans remains unknown. To address this question, we compared plasma antibodies elicited by six globally-distributed vaccines or infection and observed markedly higher binding titers for vaccines encoding a prefusion-stabilized S relative to other groups. Prefusion S binding titers positively correlated with plasma neutralizing activity, indicating that physical stabilization of the prefusion conformation enhances protection against SARS-CoV-2. We show that almost all plasma neutralizing activity is directed to prefusion S, in particular the S 1 subunit, and that variant cross-neutralization is mediated solely by RBD-specific antibodies. Our data provide a quantitative framework for guiding future S engineering efforts to develop vaccines with higher resilience to the emergence of variants and longer durability than current technologies.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results