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2,155 results on '"Ahmed, Khalil"'

6. Altered brain perfusion and oxygen levels relate to sleepiness and attention in post‐COVID syndrome

Author

Claudia Chien, Josephine Heine, Ahmed Khalil, Lars Schlenker, Tim J. Hartung, Fabian Boesl, Katia Schwichtenberg, Rebekka Rust, Judith Bellmann‐Strobl, Christiana Franke, Friedemann Paul, and Carsten Finke

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective Persisting neurological symptoms after COVID‐19 affect up to 10% of patients and can manifest in fatigue and cognitive complaints. Based on recent evidence, we evaluated whether cerebral hemodynamic changes contribute to post‐COVID syndrome (PCS). Methods Using resting‐state functional magnetic resonance imaging, we investigated brain perfusion and oxygen level estimates in 47 patients (44.4 ± 11.6 years; F:M = 38:9) and 47 individually matched healthy control participants. Group differences were calculated using two‐sample t‐tests. Multivariable linear regression was used for associations of each regional perfusion and oxygen level measure with cognition and sleepiness measures. Exploratory hazard ratios were calculated for each brain metric with clinical measures. Results Patients presented with high levels of fatigue (79%) and daytime sleepiness (45%). We found widespread decreased brain oxygen levels, most evident in the white matter (false discovery rate adjusted‐p‐value (p‐FDR) = 0.038) and cortical grey matter (p‐FDR = 0.015). Brain perfusion did not differ between patients and healthy participants. However, delayed patient caudate nucleus perfusion was associated with better executive function (p‐FDR = 0.008). Delayed perfusion in the cortical grey matter and hippocampus were associated with a reduced risk of daytime sleepiness (hazard ratio (HR) = 0.07, p = 0.037 and HR = 0.06, p = 0.034). Decreased putamen oxygen levels were associated with a reduced risk of poor cognitive outcome (HR = 0.22, p = 0.019). Meanwhile, lower thalamic oxygen levels were associated with a higher risk of cognitive fatigue (HR = 6.29, p = 0.017). Interpretation Our findings of lower regional brain blood oxygen levels suggest increased cerebral metabolism in PCS, which potentially holds a compensatory function. These hemodynamic changes were related to symptom severity, possibly representing metabolic adaptations.

Published
2024
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7. Management strategy for children with ovarian immature teratoma: results from a tertiary pediatric oncology center

Author

Gehad Ahmed, Sahar Ahmed Khalil, Maged Elshafiey, Nihal Abdelfattah, Mohamed Eid, Al-Shaimaa Zakaria, Madeeha Elwakeel, and Ahmed Elgendy

Subjects
Ovary, Immature teratoma, Surgery, Adjuvant chemotherapy, Relapse, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Objectives We present an Egyptian study on pediatric ovarian immature teratomas (ITs), aiming to clarify our treatment strategy selection. Methods A retrospective review of all children with pure ovarian ITs who were treated at our institution between 2008 and 2023. The analysis included clinical characteristics, tumor staging according to Children’s Oncology Group (COG), grading based on the Norris system, management, and outcomes. Results Thirty-two patients were included, with a median age of 9 years. All patients underwent primary surgery. Unilateral salpingo-oophorectomy was performed in 31 patients. Surgical staging was completed in all patients. Based on COG staging, there were 28 patients (87.5%) stage I, 1 (3%) stage II, and 3 (9.5%) stage III. According to Norris classification, 16 patients (50%) were classified as grade I, 9 (28%) grade II, and 7 (22%) grade III. All patients in stage I were treated using surgery-alone approach, whereas the remaining four (12.5%) received adjuvant chemotherapy. Five patients in stage I had gliomatosis peritonei (GP), and none of them underwent extensive surgery. At a median follow-up of 86 months, two patients had events. The first patient (stage III/grade I) developed IT relapse on the operative bed, and the second (stage I/grade I) had a metachronous IT on the contralateral ovary. Both patients were successfully managed with surgery followed by second-line chemotherapy. Five-year overall survival and event-free survival for all patients were 100% and 93.4%, respectively. Conclusions Surgery-alone strategy with close follow-up achieves excellent outcomes for localized ovarian ITs in children, irrespective of the Norris grading or the presence of GP. However, adjuvant chemotherapy is questionable for patients with incompletely resected or locally advanced tumors, and its role requires further evaluation through prospective multicentric studies with a larger sample size.

Published
2024
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11. Comparative Study of Staples vs Plate and Screws for Arthrodesis of the First Metatarsophalangeal Joint

Author

Rebecca S. McGaver MS, ATC, Ahmed Khalil Attia MD, Kayla J. Seiffert BA, Carissa Dock BBME, Jeffrey D. Seybold MD, and Paul M. Cammack MD

Subjects
Orthopedic surgery, RD701-811
Abstract

Category: Midfoot/Forefoot; Other Introduction/Purpose: Nitinol technology has revolutionized foot and ankle orthopaedic surgery, offering a quick and low-profile means of achieving bone healing. One application of this technology has been in the development of a first metatarsophalangeal (MTP) joint staple, utilized in place of crossing screws or a plate and interlocking screws constructs to achieve fusion at the first MTP joint. The objectives of this study were to compare radiographically and subjective outcomes for patients who had a first MTP joint fusion treated with an Enovis Dynaclip Delta staple vs those treated with a plate and interlocking screws. The hypothesis is the staple provides a quicker surgical time and equivalent rate of union compared to patients who were treated with standard plate and screws. Methods: A single-surgeon, consecutive case series of prospectively collected data was reviewed retrospectively for patients who underwent primary first MTP arthrodesis using a staple. Patients were age and gender matched to those who underwent primary first MTP arthrodesis with a plate and associated interlocking screws. Dates of surgery were November 2017 - December 2023. Exclusions included revision surgeries, prior forefoot/midfoot fusions, and ancillary fusions at the time of the index surgery. Preoperative and postoperative patient-reported outcome measures (PROMs) [Foot and Ankle Ability Measure (FAAM), Veterans-Rand 12 (VR-12) General Health Survey, visual analog pain scale (VAS), and radiographs (hallux valgus angle, dorsiflexion angle) were evaluated to compare the two groups. Comorbidities, operative time, fusion rates, and a patient satisfaction survey were also collected. Statistical analysis was performed using sutdent’s t-tests. Results: Twenty-two feet were included in both groups. Preoperative and postoperative PROMs between groups demonstrated no significant differences in all questionnaire categories assessed. The staple group demonstrated significant differences from preoperative to postoperative in FAAM ADL (p=0.004), FAAM sport (p=0.010), and VAS (p< 0.001) while plate and screws demonstrated significant differences in FAAM ADL (p=0.032) and VAS (p=0.033). The radiographic measurements revealed a significant difference in the postoperative dorsiflexion angle for staple vs plate and screws 21.81±5.72 vs 26.47±6.99, respectively (p=0.012) and there were no other significant differences noted (table). Operative time revealed a significant difference between staple vs plate and screws (30.0 minutes vs 35.73 minutes, respectively) (p=0.006). The fusion rate was 95% in both groups. Conclusion: This study reports early results for a comparison of first MTP joint fusion treated with an Enovis Dynaclip Delta staple vs those treated with the standard plate and interlocking screws. While there were statistical differences within each group between most of the preoperative and postoperative PROMs, comparing the two groups, there was none. The fusion rate was the same in both groups. The staple group had an average of 5.7 minutes less operative time. Staple fixation achieves similar union rates to plate and screw constructs with a shorter operative time. Further patients are needed to expand this cohort.

Published
2024
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12. Maintenance of Hallux Valgus Correction Treated with Modified Lapidus Procedure: Intermetatarsal Miniature Suture Button vs First Metatarsal to Intermediate Cuneiform Cross-Screw Fixation

Author

Ahmed Khalil Attia MD, Confidence Njoku Austin BA, Elizabeth Clayton BS, David Fogg MD, Jonathan Dalton MD, Alex Kline MD, Carl Hasselman MD, and Macalus V. Hogan MD, MBA

Subjects
Orthopedic surgery, RD701-811
Abstract

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: Over time our understanding of Hallux valgus deformity has continued to improve since Lapidus published his series in 1960, however, recurrence remains as high as 38%. Fixation of the first tarsometatarsal joint has been known to improve the rigidity of the construct and reduce recurrence. While some authors employ an inter-cuneiform screw between the medial and intermediate cuneiform others provide fixation using a suspensory fixation device (Arthrex mini tightrope). However, this is limited information comparing the modified Lapidus first metatarsal arthrodesis using the suture button fixation (MT1-2 SB) and the first metatarsal intermediate cuneiform screw (MT1C2 Screw). We hypothesize that the intermediate screw fixation would have better radiographic outcomes compared to the suture button fixation. Methods: This was a retrospective comparative study between patients who underwent surgical management of hallux valgus using the MT1-2 SB and the MT1C2 screw between January 2015 to January 2023. Exclusion criteria were as follows: revision or prior hallux valgus corrective surgery on the same foot, patients who received additional procedures (i.e. midfoot fusion, or flatfoot reconstruction), and incomplete medical records. Demographic variables including age, sex, body mass index (BMI), diabetes status, and smoking status were collected. Recurrence rate, union rate, hardware removal, infection rate, and patient-reported outcomes were also collected. The radiographic variables are first metatarsal declination angle (MTD), intermetatarsal angle (IMA), hallux valgus angle (HVA), and sesamoid station. Results: We had a total of 269 patients in the MT1-2 SB cohort and 93 in the MT1C2 Screw cohort. The MT1-SB group achieved a better radiographic correction for IMA (5.37 +/- 3.21 vs 6.65 +/- 3.36, p= < 0.001), HVA (16.03 +/-7.89 vs 19.81 +/- 8.47, p= < 0.001), and sesamoid stations (0.52 +/- 0.81 vs 0.76 +/- 0.90, p= 0.19). MT1-SB had a better correction at final follow-up. Diabetes status was associated with greater postoperative pain, while smoking status was associated with worse postoperative FAAM ADL score (p= 0.011 and 0.003 respectively). Smoking was associated with a greater postoperative and final HVA in addition to an increased revision rate (15.8% vs 3.5%, p=0.037). A greater recurrence rate was also seen among smokers (15.8% vs 4.4%, p=0.061). Conclusion: Suture button fixation and first metatarsal intermediate cuneiform screw fixation demonstrated similar clinical outcomes, union rates, deformity correction, and maintenance of correction at the final follow-up. Smoking was associated with a higher rate of recurrence, revision, and worse patient-reported outcomes.

Published
2024
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13. Outcomes of Deltoid Ligament Repair in Surgically Treated Weber C Fibula Fractures with Deltoid Ligament Injury. A Retrospective Comparative Radiographic and Functional Outcomes Study

Author

Ahmed Khalil Attia MD, Torben H. Urdahl BA, Rebecca S. McGaver MS, ATC, Carissa Dock BBME, Bryan D. Den Hartog MD, Chris Coetzee MD, William M. Engasser MD, Paul M. Cammack MD, John C. Tanner MD, Kayla J. Seiffert BA, and Jeffrey D. Seybold MD

Subjects
Orthopedic surgery, RD701-811
Abstract

Category: Ankle; Trauma Introduction/Purpose: The indications of deltoid ligament repair in ankle injuries with widened medial clear space in the absence of medial malleolus fracture remain controversial. Many authors reported no difference in long-term functional outcomes, while others reported persistent medial clear space widening and higher malreduction when deltoid ligaments went without repair. This malreduction can lead to chronic ankle instability and pain. Talar shift as little as 1mm is reported to lead to a 49% increase in ankle joint pressure, a detrimental factor for developing post-traumatic ankle arthritis. The purpose of this study was to compare deltoid ligament repair to no repair in a homogenous group of surgically treated isolated Weber C fibula fractures exclusively. Methods: A retrospective chart review of prospectively collected data was carried out to identify consecutive surgically treated Weber C lateral malleolus fractures and syndesmosis stabilization with associated deltoid ligament injury between February 2013-December 2023. Associated posterior/medial malleolus fractures other than avulsions, Weber A/B fractures, fibula fixation constructs besides plate and screws, Charcot neuropathy, pes planovalgus with incompetent deltoid ligament, and revisions were excluded. Those meeting inclusion criteria were split into two groups: deltoid ligament suture repair vs. no repair. Collected data included demographics, smoking and diabetes status, surgical procedure and patient reported outcome measures (PROMs).. Primary outcomes were oblique medial clear space (MCS) and valgus talar tilt angle (TTA) on weightbearing radiographs. All radiographs were independently reviewed by a fellowship trained foot and ankle orthopedic surgeon. Secondary outcomes were fracture union, complications, reoperations, and PROMs: Foot and Ankle Ability Measure (FAAM), Veterans-Rand 12 (VR12) General Health Survey, visual analog pain scale (VAS). Results: Seventy-nine fractures were included; 49 underwent deltoid ligament repair while 30 did not. The mean follow-up was 18.5 months. There was a statistically significant post-op improvement in most study outcomes within the groups. The valgus TTA in the repair vs no repair groups were 0.1±0.9 vs. 1.2±2.1 degrees, respectively (p=0.007). The MCS in the repair vs. no repair groups was 3.5±0.6 vs. 3.9±1.4mm, respectively (p=0.107). There were no statistically significant differences between deltoid repair and no repair groups in post-operative VR12 MCS (p=0.194), VR12 PCS (p=0.077), VAS (p=0.231), FAAM ADL (p=0.109), FAAM sport (p=0.314), or patient satisfaction (p=0.33). The union rate was 100% in the repair vs. 96% in the no repair groups (p=0.163). There were no complications related to repairing the deltoid ligament. Conclusion: Deltoid ligament repair led to a superior ankle coronal alignment in comparison to no repair. There were no complications or revisions related to the medial approach and repairing the deltoid ligament. While there were trends toward better functional outcomes with deltoid ligament repair, this did not reach statistical significance. Long term studies may be required before recommending deltoid ligament repair as the gold standard in isolated Weber C fractures. Meanwhile, we recommend valgus stressing the ankle at the end of the procedure and decide whether deltoid repair is needed on individual basis. Outcomes of deltoid repair group vs no deltoid repair group.

Published
2024
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14. Precision in Insurance Forecasting: Enhancing Potential with Ensemble and Combination Models based on the Adaptive Neuro-Fuzzy Inference System in the Egyptian Insurance Industry

Author

Ahmed Khalil, Zaiming Liu, and Ahmed Ali

Subjects
Electronic computers. Computer science, QA75.5-76.95, Cybernetics, Q300-390
Abstract

Enhancing the precision of retention ratio predictions holds profound significance for insurance industry decision-makers and those vested in advancing insurance services. Precision helps insurance companies navigate inflationary pressures and evaluate underwriting profitability, enabling reliable prognoses of future underwriting gains. As far as we know, although there have been multiple attempts to construct a predictive model for retention ratio, none of these attempts have used combining models or studied the Egyptian market. Therefore, this study contributes significantly to this developing field by providing combining models, which combined statistical time series models such as Exponential Smoothing (ES), and Autoregressive Integrated Moving Average (ARIMA), with Adaptive Neuro-Fuzzy Inference System (ANFIS). Two different types of combinations are employed with these models. Furthermore, the study introduces three ensemble models designed for the purpose of predicting the retention ratio within the Egyptian insurance market. Dataset was carefully gathered from the EFSA’s annual reports, focused on the property-liability insurance sector within the Egyptian insurance market and covers the time period from 1989 to 2021. Next, the proposed models are assessed employing well-established statistical assessment metrics, namely, Mean Absolute Error (MAE), Mean Absolute Percent Error (MAPE), R Square (R2), and Root Mean Square Error (RMSE). The results show that combining and ensemble methods improve predicted accuracy. A multi-linear regression-based ensemble model that combines ARIMA, ES, and ANFIS models outperforms both single and combined models in robustness. The article concludes that the insurance industry can greatly benefit from modern predictive methods to make sound decisions.

Published
2024
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15. Bioaccessibility mechanisms, fortification strategies, processing impact on bioavailability, and therapeutic potentials of minerals in cereals

Author

Muhammad Faisal Manzoor, Anwar Ali, Huma Badar Ul Ain, Samina Kausar, Anees Ahmed Khalil, Rana Muhammad Aadil, and Xin-An Zeng

Subjects
Cereal minerals, Bioaccessibility, Bioavailability, Fortification strategies, Processing impact, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

Minerals are essential to our diet. They affect nerve and muscle function, build materials for our bones, and regulate the body's water balance. The bioaccessibility and bioavailability of cereal minerals depend upon various aspects, such as plant cell wall configuration, storage chemical form of a mineral, plant tissue localization, and processing conditions. Fortification of minerals is done through classical methods and agro-biotechnological techniques to combat micronutrient deficiencies and improve bioavailability. The recent innovative approaches (chelation and encapsulation) overwhelm issues associated with classical fortification methods, specifically those influencing bioavailability and organoleptic properties. Food processing techniques, such as fermenting, soaking, cooking, and germination, significantly improved mineral bioavailability by reducing phytic acid and other antinutritional factors. Minerals, particularly micro-ones, are lost irreversibly during food processing, and their losses can be reduced by changing the processing strategies. The current review explores minerals in cereals, their bioaccessibility, bioavailability, fortification strategies, the impact of food processing on bioavailability, and their therapeutic potential.

Published
2024
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16. Ultrasound-assisted solvent extraction of phenolics, flavonoids, and major triterpenoids from Centella asiatica leaves: A comparative study

Author

Tara Khursheed, Anees Ahmed Khalil, Muhammad Nadeem Akhtar, Ahood Khalid, Muhammad Rizwan Tariq, Tawfiq Alsulami, Robert Mugabi, and Gulzar Ahmad Nayik

Subjects
Ultrasonication, Bioactive compounds, Triterpenoids, Superoxide radical, Chemistry, QD1-999, Acoustics. Sound, QC221-246
Abstract

Centella asiatica has been known for its significant medicinal properties due to abundance of bioactive constituents like triterpenoids and flavonoids. Nevertheless, an appropriate solvent system and extraction technique is still lacking to ensure optimized extraction of bioactive constituents present in C. asiatica. Recently, scientists are more focused towards application of green sustainable extraction techniques for the valuable components from plant matrix owing to their eco-friendly and safe nature. Among these, ultrasonication (US) is known as a valuable strategy for separation of bioactive components from medicinal plants. Hence, current research was performed to observe the effect of ultrasonication in the presence of five different solvents (Water, Hexane, Methanol, Chloroform, and Ethyl acetate) on total phenolic contents (TPC), total flavonoid contents (TFC), antioxidant properties (DPPH, ABTS, Nitric oxide radical activity, and Superoxide anion assay), and four major triterpenoid contents in C. asiatica leaves. Herein, ultrasound assisted methanolic extract (UAME) possessed maximum amount of TPC (129.54 mg GAE/g), TFC (308.31 mg QE/g), and antioxidant properties (DPPH: 82.21 % & FRAP: 45.98 µmol TE/g) followed by ultrasound-assisted Water extract (UAWE), ultrasound-assisted ethyl acetate extract (UAEAE), ultrasound-assisted n-hexane extract (UAHE), and ultrasound-assisted chloroform extract (UACE), respectively. Moreover, the superoxide radical and nitric oxide assays depicted a similar trend, revealing the highest percent inhibition for UAME (SO: 83.47 % & NO: 66.76 %) however, the lowest inhibition was displayed by UACE (63.22 % & 50.21 %), respectively. Highest content of major terpenoids were found in UAME of C. asiatica leaves as madecassoside (8.21 mg/g) followed by asiaticoside (7.82 mg/g), madecassic acid (4.44 mg/g), and asiatic acid (3.38 mg/g). Ultrasound-assisted extraction technique can be an efficient extraction method for bioactive compounds present in C. asiatica. However, ultrasonication along with methanol as an extraction solvent can surely enhance the extraction of valuable constituents. The results of this study provide an insight into major terpenoids, and antioxidants present in extracts of C. asiatica, implicating its use in ancient medicine systems and future drug development.

Published
2024
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18. Level of insight in Egyptian patients having obsessive compulsive disorder: a comparative study

Author

Mohamed Hossam el din Abdelmoneam, Amira Nassieb Elbatrawy, Sherien Ahmed Khalil, Riham Ahmad Shalaby, and Moatazbellah Ibrahim Ali

Subjects
Insight, Obsessive compulsive disorder, Yale–Brown Obsessive–Compulsive Scale, Brown Assessment of Beliefs Scale, Psychiatry, RC435-571
Abstract

Abstract Background and objectives Obsessive–compulsive disorder (OCD) is a chronic psychiatric disorder defined by the existence of obsessions and/or compulsive behaviors or mental acts persistently and affects around 1–3% of the population in the world. Multiple studies demonstrated the link of the insight level to how severe was OCD and existence of resistance to both medications and psychotherapy in individuals with OCD. Studying the characteristics associated with poor insight is very important for management of treatment-resistant OCD and development of new therapeutic approaches. The purpose of this work was to assess the level of the insight in Egyptian patients with OCD, identify clinical correlates that could anticipate the degree of insight, and assess the validity and reliability of brown assessment of belief scale after being translated to Arabic version. Methods A comparative cross-sectional study of 96 individuals (male and female aged from 18 to 60) diagnosed with OCD based on the Arabic version of the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). The study excluded any individuals with any coexisting neuro-psychiatric conditions and a history of major medical disease. Severity of OCD was assessed through the Arabic version of the Yale–Brown Obsessive–Compulsive Scale (YBOCS). Subsequently, participants performed the Brown Assessment of Beliefs Scale (BABS) after being translated into Arabic and assessed for reliability, validity and applicability of the translated form. Results Patients with OCD presented with poor insight were associated with more untreated time interval, longer disease duration and more severity that was dramatically differed (p ≤ 0.05, ≤ 0.001, ≤ 0.05 respectively). Also, there was a substantial notable correlation among BABS and YBOCS obsession, compulsion, and total score. Conclusions The existence of good insight in patients diagnosed with OCD was associated with lower severity and less duration of illness compared to patients with poor insight. Also, the more time waited before the intervention the worst the patient scores on the insight scale.

Published
2024
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19. Fronto-thalamic networks and the left ventral thalamic nuclei play a key role in aphasia after thalamic stroke

Author

Ida Rangus, Ana Sofia Rios, Andreas Horn, Merve Fritsch, Ahmed Khalil, Kersten Villringer, Birgit Udke, Manuela Ihrke, Ulrike Grittner, Ivana Galinovic, Bassam Al-Fatly, Matthias Endres, Anna Kufner, and Christian H. Nolte

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Thalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level neural substrates of thalamic aphasia remain incompletely understood. Using lesion symptom mapping, we demonstrate that lesions in the left ventrolateral and ventral anterior thalamic nucleus are most strongly associated with aphasia in general and with impaired semantic and phonemic fluency and complex comprehension in particular. Lesion network mapping (using a normative connectome based on fMRI data from 1000 healthy individuals) reveals a Thalamic aphasia network encompassing widespread left-hemispheric cerebral connections, with Broca’s area showing the strongest associations, followed by the superior and middle frontal gyri, precentral and paracingulate gyri, and globus pallidus. Our results imply the critical involvement of the left ventrolateral and left ventral anterior thalamic nuclei in engaging left frontal cortical areas, especially Broca’s area, during language processing.

Published
2024
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20. Anti-inflammatory and anti-diabetic properties of indanone derivative isolated from Fernandoa adenophylla in vitro and in silico studies

Author

Abdur Rauf, Umer Rashid, Zafar Ali Shah, Anees Ahmed Khalil, Muhammad Shah, Tabussam Tufail, Gauhar Rehman, Abdur Rahman, Saima Naz, Abdulrahman Alsahammari, Metab Alharbi, Abdulmajeed AL-Shahrani, and Dorota Formanowicz

Subjects
Fernandoa adenophylla, Anti-inflammatory, Anti-diabetic, In silico study, Medicine, Science
Abstract

Abstract Fernandoa adenophylla, due to the presence of phytochemicals, has various beneficial properties and is used in folk medicine to treat many conditions. This study aimed to isolate indanone derivative from F. adenophylla root heartwood and assess in-vitro anti-inflammatory and anti-diabetic characteristics at varying concentrations. Heat-induced hemolysis and glucose uptake by yeast cells assays were conducted to evaluate these properties. Besides, docking analyses were performed on four molecular targets. These studies were combined with molecular dynamics simulations to elucidate the time-evolving inhibitory effect of selected inhibitors within the active pockets of the target proteins (COX-1 and COX-2). Indanone derivative (10–100 µM) inhibited the lysis of human red blood cells from 9.12 ± 0.75 to 72.82 ± 4.36% and, at 5–100 µM concentrations, it significantly increased the yeast cells’ glucose uptake (5.16 ± 1.28% to 76.59 ± 1.62%). Concluding, the isolated indanone might act as an anti-diabetic agent by interacting with critical amino acid residues of 5′ adenosine monophosphate-activated protein kinase (AMPK), and it showed a binding affinity with anti-inflammatory targets COX-1, COX-2, and TNF-α. Besides, the obtained results may help to consider the indanone derivative isolated from F. adenophylla as a promising candidate for drug delivery, subject to outcomes of further in vivo and clinical studies.

Published
2024
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24. UAE National Day: a celebration of unity, progress

Author

Ahmed, Khalil

Subjects
United Arab Emirates -- Rites, ceremonies and celebrations, Business, international
Abstract

Byline: Khalil Ahmed Interview with Mr. Ibad Ali, a UAE-based Pakistani PAGE: Tell me something about yourself, please: Ibad Ali: I am a Certified Cost and Management Accountant (CMA). Currently, [...]

Published
2024

25. Kinnow industry's future looks bleak

Author

Ahmed, Khalil

Subjects
Fruit industry -- Exports -- Industry forecasts, Citrus fruits -- Exports, Citrus -- Exports, Business, international
Abstract

Byline: Khalil Ahmed Interview with Mr. Waheed Ahmed, Patron-in-Chief of All Pakistan Fruit and Vegetable Exporters Association (PFVA) Mr. Waheed Ahmed , shared his perspective with PAKISTAN and GULF ECONOMIST [...]

Published
2024

26. Important Milestone

Author

Ahmed, Khalil

Subjects
Pakistan -- Economic aspects, Capital market -- Statistics -- Growth, Company growth, Business, international
Abstract

Byline: Khalil Ahmed Pakistan Stock Exchange (PSX) held a Gong Ceremony to formally welcome Ahsan Iqbal, Federal Minister for Planning, Development, and Special Initiatives, Government of Pakistan. The gong was [...]

Published
2024

27. Compression and tension forces in bamboo truss with curved model

Author

Omar Khaled Farouk Ahmed Khalil and Yulianto Purwono Prihatmaji

Subjects
Bamboo truss, Strength stress, Vertical load, Architecture, NA1-9428, Architectural engineering. Structural engineering of buildings, TH845-895
Abstract

Enhancing the strength performance of bamboo truss. This paper discusses the performance of a customize bamboo truss and emphasizing how stress forces interact under vertical loads. The customize truss with a span 4 meters and a height with 2 meters, comprises three components; the base, truss legs and bracing. At the base of the truss underneath, whole bamboo is utilized. In contrast, the bracing section employs curved stacks of split bamboo. The design variation allows for structural support while incorporating the flexibility and strength of bamboo in different parts of the truss. It’s essential to ensure the structural integrity and load-bearing capacity in bamboo trusses. The aim of this study to investigate how the customize truss respond to the stress forces, focusing on the ability to withstand vertical loads. This research collecting data by using a quantitative methods after customizing a unique model of bamboo truss with curved stacks then conducting an experiment under hydraulic test. As a result the curved stacks model in the customize truss successes to withstand 4.78 KN vertical load.

Published
2024
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30. Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Author

Moharam, S.A., Abdalasalam, Sabriya, Abdalhadi, Alaa Abdalfattah, Abdalla, Naana Reyam, Abdalla, Walaa, Abdalrheem, Almthani Hamza, Abdalsalam, Ashraf, Abdeewi, Saedah, Abdelgaum, Esraa Hassan, Abdelhalim, Mohamed, Abdelkabir, Mohammed, Abdelrahman, Israa, Abdukahil, Sheryl Ann, Abdulbaqi, Lamees Adil, Abdulhamid, Salaheddin, Abdulhamid, Widyan, Abdulkadir, Nurul Najmee, Abdulwahed, Eman, Abdunabi, Rawad, Abe, Ryuzo, Abel, Laurent, Abodina, Ahmed Mohammed, Abrous, Amal, Absil, Lara, Jabal, Kamal Abu, Salah, Nashat Abu, Abusalama, Abdurraouf, Abuzaid, Tareg Abdallah, Acharya, Subhash, Acker, Andrew, Adam, Elisabeth, Adem, Safia, Ademnou, Manuella, Adewhajah, Francisca, Adrião, Diana, Afum-Adjei Awuah, Anthony, Agbogbatey, Melvin, Al Ageel, Saleh, Ahmed, Aya Mustafa, Ahmed, Musaab Mohammed, Ahmed, Shakeel, Alaraji, Zainab Ahmed, Elhefnawy Enan, Abdulrahman Ahmed, Ahmed Khalil, Reham Abdelhamid, Ahmed Mohamed Abdelaziz, Ali Mostafa, Ainscough, Kate, Airlangga, Eka, Aisa, Tharwat, Aisha, Ali, Aisha, Bugila, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Akwani, Chika, Al Qasim, Eman, Alajeeli, Ahmed, Alali, Ahmed, Alalqam, Razi, Alameen, Aliya Mohammed, Al-Aquily, Mohammed, Alaraji, Zinah A., Albakry, Khalid, Albatni, Safa, Alberti, Angela, Aldabbourosama, Osama, Al-dabbous, Tala, Aldhalia, Amer, Aldoukali, Abdulkarim, Alegesan, Senthilkumar, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Al-Fares, Abdulrahman, Alflite, Asil, Alfoudri, Huda, Alhadad, Qamrah, Alhaddad, Hoda Salem, Mohamed Abdalla Alhasan, Maali Khalid, Alhouri, Ahmad Nabil, Alhouri, Hasan, Ali, Adam, Ali, Imran, TagElser Mohammed Ali, Maha, Abbas, Syed Ali, Abdelghafar, Yomna Ali, Sheikh, Naseem Ali, Alidjnou, Kazali Enagnon, Aljadi, Mahmoud, Aljamal, Sarah, Alkahlout, Mohammed, Alkaseek, Akram, Alkhafajee, Qabas, Allavena, Clotilde, Allou, Nathalie, Almasri, Lana, Almjersah, Abdulrahman, Alqandouz, Raja Ahmed, Alrfaea, Walaa, Alrifaee, Moayad, Alsaadi, Rawan, Al-Saba'a, Yousef, Alshareea, Entisar, Alshenawy, Eslam, Altaf, Aneela, Alves, João Melo, Alves, João, Alves, Rita, Cabrita, Joana Alves, Amaral, Maria, Amer, Amro Essam, Amira, Nur, Adusei, Amos Amoako, Amuasi, John, Andini, Roberto, Andrejak, Claire, Angheben, Andrea, Angoulvant, François, Ankrah, Sophia, Ansart, Séverine, Anthonidass, Sivanesen, Antonelli, Massimo, Antunes de Brito, Carlos Alexandre, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Arancibia, Francisco, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Aryal, Diptesh, Asensio, Angel, Ashley, Elizabeth A., Ashraf, Muhammad, Ashraf, Muhammad Sheharyar, Ben Ashur, Abir, Asiedu-Bekoe, Franklin, Asif, Namra, Asim, Mohammad, Assi, Grace, Assie, Jean Baptiste, Asyraf, Amirul, Atangana, Fouda, Atia, Ahmed, Atif, Minahel, Abdelrhman Abdallahrs, Asia Atif, Atique, Anika, Atlowly, Moad, Attanyake, AM Udara Lakshan, Auchabie, Johann, Aumaitre, Hugues, Auvet, Adrien, Ali Mohammed, Abdelmalek Awad, Axelsen, Eyvind W., Ayad, Ared, Hassan Helmi, Ahmed Ayman, Azemar, Laurène, Azizeldin, Mohammed, Azoulay, Cecile, Babatunde, Hakeem, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Bævre-Jensen, Roar, Baig, Nadia, Baillie, John Kenneth, Baird, J Kevin, Bak, Erica, Bakakos, Agamemnon, Bakar, Nazreen Abu, Bakeer, Hibah Bileid, Bakri, Ashraf, Bal, Andriy, Balakrishnan, Mohanaprasanth, Bandoh, Irene, Bani-Sadr, Firouzé, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnett, Saef Umar, Barnikel, Michaela, Barrasa, Helena, Barrigoto, Cleide, Bartoli, Marie, Baruch, Joaquín, Basmaci, Romain, Basri, Muhammad Fadhli Hassin, Batool, AbdAlkarim, Battaglini, Denise, Bauer, Jules, Bautista Rincon, Diego Fernando, Dow, Denisse Bazan, Beane, Abigail, Bedossa, Alexandra, Bee, Ker Hong, Begum, Husna, Behilill, Sylvie, Beishuizen, Albertus, Beljantsev, Aleksandr, Bellemare, David, Beltrame, Anna, Beltrão, Beatriz Amorim, Beluze, Marine, Benech, Nicolas, Benjiman, Lionel Eric, Bennett, Suzanne, Bento, Luís, Berdal, Jan-Erik, Berdeweel, Lamis, Bergeaud, Delphine, Bergin, Hazel, Bertoli, Giulia, Bertolino, Lorenzo, Bessis, Simon, Bevilcaqua, Sybille, Bezulier, Karine, Bhatt, Amar, Bhavsar, Krishna, Bianchi, Isabella, Bianco, Claudia, Bichoka, Sandra, Bidin, Farah Nadiah, Humaid, Felwa Bin, Bin Kamarudin, Mohd Nazlin, Binnawara, Muhannud, Bisoffi, Zeno, Biston, Patrick, Bitker, Laurent, Bittaye, Mustapha, Bitton, Jonathan, Blanco-Schweizer, Pablo, Blier, Catherine, Bloos, Frank, Blot, Mathieu, Boccia, Filomena, Bodenes, Laetitia, Bogaert, Debby, Boivin, Anne-Hélène, Bolanga, Ariel, Bolaños, Isabela, Bolze, Pierre-Adrien, Bompart, François, Bonifasius, Aurelius, Bonney, Joe, Borges, Diogo, Borie, Raphaël, Bosse, Hans Martin, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camile, Bountthasavong, Latsaniphone, Boureau, Anne-Sophie, Bourke, John, Bouscambert, Maude, Bousquet, Aurore, Boyer-Besseyre, Marielle, Boylan, Maria, Bozza, Fernando Augusto, Braconnier, Axelle, Braga, Cynthia, Brandenburger, Timo, Monteiro, Filipa Brás, Brazzi, Luca, Breen, Dorothy, Breen, Patrick, Brewster, David, Brickell, Kathy, Broadley, Tessa, Brotherton, Helen, Browne, Alex, Brozzi, Nicolas, Brunvoll, Sonja Hjellegjerde, Brusse-Keizer, Marjolein, Bryda, Petra, Buchtele, Nina, Bugaeva, Polina, Buisson, Marielle, Buonsenso, Danilo, Burhan, Erlina, Buri, Donald, Burrell, Aidan, Bustos, Ingrid G., Butnaru, Denis, Cabie, André, Cabral, Susana, Cabrita, Joana, Caceres, Eder, Cadoz, Cyril, Garcês, Rui Caetano, Calligy, Kate, Calvache, Jose Andres, Camões, João, Campana, Valentine, Campbell, Paul, Campisi, Josie, Canepa, Cecilia, Cantero, Mireia, Caoili, Janice, Caraux-Paz, Pauline, Cárcel, Sheila, Cardoso, Filipa, Cardoso, Filipe, Cardoso, Nelson, Cardoso, Sofia, Carelli, Simone, Carlier, Nicolas, Carmoi, Thierry, Carney, Gayle, Carqueja, Inês, Carret, Marie-Christine, Carrier, François Martin, Carroll, Ida, Carson, Gail, Casanova, Maire-Laure, Cascão, Mariana, Casey, Siobhan, Casimiro, José, Cassandra, Bailey, Castañeda, Silvia, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cattaneo, Paolo, Cavalin, Roberta, Cavalli, Giulio Giovanni, Cavayas, Alexandros, Ceccato, Adrian, Ceesay, Masaneh, Cerkovnik, Shelby, Cervantes-Gonzalez, Minerva, Cevik, Muge, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Chapplain, Jean-Marc, Charpentier, Charlotte, Chas, Julie, Chaudry, Muhammad Mobin, Chávez Iñiguez, Jonathan Samuel, Chen, Anjellica, Chen, Yih-Sharng, Chenard, Léo, Cheng, Matthew Pellan, Cheret, Antoine, Chiarabini, Thibault, Chica, Julian, Chidambaram, Suresh Kumar, Tho, Leong Chin, Chirouze, Catherine, Chiumello, Davide, Cho, Sung-Min, Cholley, Bernard, Chommanam, Danoy, Chopin, Marie-Charlotte, Chow, Yock Ping, Chow, Ting Soo, Christy, Nathaniel, Chua, Hiu Jian, Chua, Jonathan, Cidade, Jose Pedro, Cisneros Herreros, José Miguel, Citarella, Barbara Wanjiru, Ciullo, Anna, Clarke, Jennifer, Claure-Del Granado, Rolando, Clohisey, Sara, Codan, Cassidy, Cody, Caitriona, Coles, Jennifer, Coles, Megan, Colin, Gwenhaël, Collins, Michael, Combs, Pamela, Connolly, Jennifer, Connor, Marie, Conrad, Anne, Conway, Elaine, Cooke, Graham S., Cordel, Hugues, Corley, Amanda, Cornelis, Sabine, Cornet, Alexander Daniel, Corpuz, Arianne Joy, Cortegiani, Andrea, Corvaisier, Grégory, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, Cousse, Stéphanie, Cowan, Juthaporn, Cregan, Rachel, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Csete, Marc, Cullen, Ailbhe, Cummings, Matthew, Curley, Gerard, Curlier, Elodie, Curran, Colleen, Custodio, Paula, da Silva Filipe, Ana, Da Silveira, Charlene, Dabaliz, Al-Awwab, Dagens, Andrew, Dahl, John Arne, Dahly, Darren, D'Alessandro, Umberto, Daley, Peter, Dalloul, Zaina, Dalton, Heidi, Dalton, Jo, Daly, Seamus, Damas, Juliana, Dame, Joycelyn, Damien, Cammandji, Daneman, Nick, Dantas, Jorge, D'Aragon, Frédérick, de Loughry, Gillian, de Mendoza, Diego, De Montmollin, Etienne, França, Rafael Freitas de Oliveira, Isabel de Pinho Oliveira, Ana, De Rosa, Rosanna, De Rose, Cristina, de Silva, Thushan, de Vries, Peter, Deacon, Jillian, Dean, David, Debard, Alexa, DeBenedictis, Bianca, Debray, Marie-Pierre, DeCastro, Nathalie, Dechert, William, Decours, Romain, Defous, Eve, Delacroix, Isabelle, Delamou, Alexandre, Delaveuve, Eric, Delavigne, Karen, Delfos, Nathalie M., Deligiannis, Ionna, Dell'Amore, Andrea, Delmas, Christelle, Delobel, Pierre, Delsing, Corine, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Descamps, Diane, Desvallées, Mathilde, Dewayanti, Santi, Dhangar, Pathik, Diallo, Alpha, Diallo, Souleymane Taran, Diamantis, Sylvain, Dias, André, Da Silva, Fernanda Dias, Diaz, Rodrigo, Diaz, Juan Jose, Diaz, Priscila, Dibba, Bakary K., Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diop, Fara, Diouf, Alphonsine, Dishon, Yael, Djadda, Cedric, Djossou, Félix, Docherty, Annemarie B., Doherty, Helen, Dondorp, Arjen M., Donnelly, Christl A., Donohue, Yoann, Donohue, Sean, Doran, Peter, Dorival, Céline, D'Ortenzio, Eric, Doshi, Yash, Douangdala, Phouvieng, Douglas, James Joshua, Douma, Renee, Dournon, Nathalie, Downey, Joanne, Downing, Mark, Drake, Thomas, Driscoll, Aoife, Duah, Ibrahim Kwaku, Fonseca, Claudio Duarte, Dubee, Vincent, Dubos, François, Dubot-Pérès, Audrey, Ducancelle, Alexandre, Duculan, Toni, Dudman, Susanne, Duggal, Abhijit, Dunand, Paul, Dunning, Jake, Duplaix, Mathilde, Durante-Mangoni, Emanuele, Durham, Lucian, III, Dussol, Bertrand, Duthoit, Juliette, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Ean, Sim Choon, Ebo, Ada, Echeverria-Villalobos, Marco, Edelstein, Michael, Egan, Siobhan, Eggesbø, Linn Margrete, Ehzaz, Khadeja, Eira, Carla, El Sanharawi, Mohammed, El Sayed, Marwan, Elabid, Mohammed, Elagili, Mohamed Bashir, Elapavaluru, Subbarao, Elbahnasawy, Mohammad, Elboshra, Sohail, Elharrar, Brigitte, Ellerbroek, Jacobien, Ellingjord-Dale, Merete, ELMagrahi, Hamida, Elmubark, Mohammad Muatasm, Elotmani, Loubna, Eloundou, Lauren, Eloy, Philippine, Elshaikhy, Basma, Elshazly, Tarek, Elsokni, Wafa, Eltayeb, Aml Ahmed, Elyazar, Iqbal, Emad, Zarief Kamel, Embarek, Hussein, Enderle, Isabelle, Endo, Tomoyuki, Eneli, Gervais, Eng, Chan Chee, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Esaadi, Haneen, Esperatti, Mariano, Esperou, Hélène, Santo, Catarina Espírito, Esposito-Farese, Marina, Essaka, Rachel, Essuman, Lorinda, Estevão, João, Etienne, Manuel, Everding, Anna Greti, Evers, Mirjam, Fabre, Isabelle, Fabre, Marc, Fadera, Ismaila, Abdalla Fadlalla, Asgad Osman, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron J., Fakar, Zul, Fareed, Komal, Faria, Pedro, Farooq, Ahmed, Fateena, Hanan, Fathi, Mohamed, Fatima, Salem, Fatoni, Arie Zainul, Faure, Karine, Favory, Raphaël, Fayed, Mohamed, Feely, Niamh, Fernandes, Jorge, Fernandes, Marília Andreia, Fernandes, Susana, Ferrand, François-Xavier, Devouge, Eglantine Ferrand, Ferrão, Joana, Ferraz, Mário, Ferreira, Benigno, Ferreira, Isabel, Ferreira, Bernardo, Ferreira, Sílvia, Ferriere, Nicolas, Ficko, Céline, Figueiredo-Mello, Claudia, Finlayson, William, Flament, Thomas, Fletcher, Tom, Florence, Aline-Marie, Florio, Letizia Lucia, Flynn, Brigid, Flynn, Deirdre, Foley, Jean, Fomin, Victor, Fonseca, Tatiana, Fontela, Patricia, Forrest, Karen, Forsyth, Simon, Foster, Denise, Foti, Giuseppe, Fotso, Berline, Fourn, Erwan, Fowler, Robert A., Fraher, Marianne, Franch-Llasat, Diego, Fraser, Christophe, Fraser, John F., Freire, Marcela Vieira, Ribeiro, Ana Freitas, French, Craig, Friedrich, Caren, Fritz, Ricardo, Fry, Stéphanie, Fuentes, Nora, Fukuda, Masahiro, Argin, G., Gaborieau, Valérie, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charles, Gagneux-Brunon, Amandine, Gai, Abdou, Gaião, Sérgio, Skeie, Linda Gail, Galal Mohamed Ramadan, Adham Mohamed, Gallagher, Phil, Gamble, Carrol, Gani, Yasmin, Garan, Arthur, Garcia, Rebekha, Garcia-Diaz, Julia, Garcia-Gallo, Esteban, Garimella, Navya, Garot, Denis, Garrait, Valérie, Gauli, Basanta, Gavrylov, Anatoliy, Gaymard, Alexandre, Gebauer, Johannes, Geraud, Eva, Morlaes, Louis Gerbaud, Germano, Nuno, Ghemmeid, Malak, Ghisulal, Praveen Kumar, Ghosn, Jade, Giani, Marco, Gigante, Tristan, Gilroy, Elaine, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Giwangkancana, Gezy, Glikman, Daniel, Glybochko, Petr, Gnall, Eric, Goco, Geraldine, Goehringer, François, Goepel, Siri, Goffard, Jean-Christophe, Goh, Jin Yi, Golács, Brigitta, Golob, Jonathan, Gomez, Kyle, Gómez-Junyent, Joan, Gominet, Marie, Gonzalez, Alicia, Gordon, Patricia, Gorenne, Isabelle, Goubert, Laure, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Graf, Jeronimo, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Grazioli, Lorenzo, Green, Christopher A., Greene, Courtney, Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Grovogui, Fassou Mathias, Gruner, Heidi, Gu, Yusing, Guedj, Jérémie, Guego, Martin, Guerguerian, Anne-Marie, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, Guimarães de Castro, Maisa, Guimard, Thomas, Haalboom, Marieke, Haber, Daniel, Hachemi, Ali, Haddud, Abdurrahman, Hadri, Nadir, Hafez, Wael, Haidri, Fakhir Raza, Rida Hajij, Fatima Mhd, Hakak, Sheeba, Hall, Adam, Hall, Matthew, Halpin, Sophie, Hamdan, Shaher, Hamdi, Abdelhafeez, Hameed, Jawad, Hamer, Ansley, Hamers, Raph L., Hamidfar, Rebecca, Hammarström, Bato, Hammond, Naomi, Hammond, Terese, Han, Lim Yuen, Hanan, Matly, Haniffa, Rashan, Hao, Kok Wei, Hardwick, Hayley, Harrison, Ewen M., Harrison, Janet, Ekow Harrison, Samuel Bernard, Hartman, Alan, Hasan, Sulieman, Nabil Hasan, Mohammad Ali, Hasan, Mohd Shahnaz, Hashmi, Junaid, Hashmi, Madiha, Hassan, Amoni, Hassanin, Ebtisam, Hayat, Muhammad, Hayes, Ailbhe, Hays, Leanne, Heerman, Jan, Heggelund, Lars, Helmi, Ahmed, Hendry, Ross, Hennessy, Martina, Henriquez-Trujillo, Aquiles Rodrigo, Hentzien, Maxime, Hernandez, Diana, Hershey, Andrew, Hesstvedt, Liv, Hidayah, Astarini, Higgins, Eibhlin, Higgins, Rupert, Hinton, Samuel, Hiraiwa, Hiroaki, Hirkani, Haider, Hitoto, Hikombo, Ho, Antonia, Ho, Yi Bin, Hoctin, Alexandre, Hoffmann, Isabelle, Hoh, Wei Han, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Horcajada, Juan Pablo, Houas, Ikram, Houderi, Mabrouka, Hough, Catherine L., Houltham, Stuart, Ming-Yang Hsu, Jimmy, Hulot, Jean-Sébastien, Hurd, Abby, Hussain, Iqbal, Hussein, Aliae Mohamed, Hussein, Mahmood, Ibrahim, Fatima, Ibran, Bashir, Ijaz, Samreen, Ikram, M. Arfan, Illana, Carlos Cañada, Imbert, Patrick, Ansari, Muhammad Imran, Sikander, Rana Imran, Inácio, Hugo, Dominguez, Carmen Infante, Ing, Yun Sii, Ippolito, Mariachiara, Irawany, Vera, Isgett, Sarah, Isidoro, Tiago, Ismail, Nadiah, Isnard, Margaux, Istre, Mette Stausland, Itai, Junji, Ivulich, Daniel, Jaafar, Danielle, Jaafoura, Salma, Jaber, Hamza, Jabot, Julien, Jackson, Clare, Jagne, Abubacarr, Jaureguiberry, Stéphane, Jaworsky, Denise, Jego, Florence, Jelani, Anilawati Mat, Jenum, Synne, Jimbo-Sotomayor, Ruth, Joe, Ong Yiaw, Jorge García, Ruth Noemí, Jørgensen, Silje Bakken, Joseph, Cédric, Joseph, Mark, Joshi, Swosti, Jourdain, Mercé, Jouvet, Philippe, Jung, Anna, Jung, Hanna, Juzar, Dafsah, Kafif, Ouifiya, Kaguelidou, Florentia, Kaisbain, Neerusha, Kaleesvran, Thavamany, Kali, Sabina, Kalleberg, Karl Trygve, Kalomoiri, Smaragdi, Ayadi Kamaluddin, Muhammad Aisar, Kamano, Armand Saloun, Che Kamaruddin, Zul Amali, Kamarudin, Nadiah, Kamineni, Kavita, Kandamby, Darshana Hewa, Kang, Kong Yeow, Kanwal, Darakhshan, Kanyawati, Dyah, Karghul, Mohamed, Karpayah, Pratap, Karsies, Todd, Kartsonaki, Christiana, Kasugai, Daisuke, Katz, Kevin, Kay, Christy, Kayyali, Lamees, Keating, Seán, Kedia, Pulak, Kelly, Andrea, Kelly, Aoife, Kelly, Claire, Kelly, Niamh, Kelly, Sadie, Kelly, Yvelynne, Kelsey, Maeve, Kennon, Kalynn, Keomany, Sommay, Kernan, Maeve, Kerroumi, Younes, Keshav, Sharma, Khail, Shams, Khaled, Sarah, Khalid, Imrana, Khalil, Antoine, Khan, Irfan, Khan, Quratul Ain, Khanal, Sushil, Khatak, Abid, Kherajani, Krish, Kho, Michelle E., Khoo, Denisa, Khoo, Ryan, Khoo, Saye, Khoso, Muhammad Nasir, Khuwaja, Amin, Kiat, Khor How, Kida, Yuri, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Kim, Jae Burm, Kimmoun, Antoine, Kindgen-Milles, Detlef, Kitamura, Nobuya, Kjetland Kjetland, Eyrun Floerecke, Klenerman, Paul, Klont, Rob, Bekken, Gry Kloumann, Knight, Stephen R., Kobbe, Robin, Forson, Paa Kobina, Kodippily, Chamira, Vasconcelos, Malte Kohns, Koirala, Sabin, Komatsu, Mamoru, Abebrese, Franklina Korkor, Korten, Volkan, Kouba, Stephanie, Kourouma, Mohamed Lamine, Kourouma, Karifa, Kpangon, Arsène, Krawczyk, Karolina, Kredan, Ali, Krishnan, Vinothini, Krishnan, Sudhir, Kruglova, Oksana, Krund, Anneli, Kuan, Pei Xuan, Kumar, Ashok, Kumar, Deepali, Kumar, Ganesh, Kumar, Mukesh, Kuriakose, Dinesh, Kurtzman, Ethan, Kutsogiannis, Demetrios, Kutsyna, Galyna, Bedu-Addo, Ama Kwakyewaa, Kwedi, Sylvie, Kyriakoulis, Konstantinos, Lachatre, Marie, Lacoste, Marie, Laffey, John G., Lafhej, Nadhem, Lagrange, Marie, Laine, Fabrice, Lairez, Olivier, Lakhey, Sanjay, Lambert, Marc, Lamontagne, François, Langelot-Richard, Marie, Langlois, Vincent, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Lasry, Stéphane, Lath, Sakshi, Latif, Naveed, Latifeh, Youssef, Launay, Odile, Laureillard, Didier, Lavie-Badie, Yoan, Law, Andy, Lawrence, Cassie, Lawrence, Teresa, Le, Minh, Le Bihan, Clément, Le Bris, Cyril, Le Falher, Georges, Le Fevre, Lucie, Le Hingrat, Quentin, Le Maréchal, Marion, Le Mestre, Soizic, Le Moal, Gwenaël, Le Moing, Vincent, Le Nagard, Hervé, Leal, Ema, Santos, Marta Leal, Lee, Biing Horng, Lee, Heng Gee, Lee, Su Hwan, Lee, James, Lee, Jennifer, Lee, Todd C., Lee, Yi Lin, Leeming, Gary, Lefebvre, Bénédicte, Lefebvre, Laurent, Lefèvre, Benjamin, LeGac, Sylvie, Lehiste, Merili-Helen, Lelievre, Jean-Daniel, Lellouche, François, Lemaignen, Adrien, Lemee, Véronique, Lemeur, Anthony, Lemmink, Gretchen, Lene, Ha Sha, Lennon, Jenny, León, Rafael, Leone, Marc, Lepik, Tanel, Lepiller, Quentin, Lescure, François-Xavier, Lesens, Olivier, Lesouhaitier, Mathieu, Lester-Grant, Amy, Letizia, Andrew, Letrou, Sophie, Levy, Bruno, Levy, Yves, Levy-Marchal, Claire, Lewandowska, Katarzyna, L'Her, Erwan, Bassi, Gianluigi Li, Liang, Janet, Liaquat, Ali, Liegeon, Geoffrey, Lim, Kah Chuan, Lim, Wei Shen, Lima, Chantre, Lina, Bruno, Lina, Lim, Lind, Andreas, Lingad, Maja Katherine, Lingas, Guillaume, Lion-Daolio, Sylvie, Liu, Keibun, Livrozet, Marine, Lizotte, Patricia, Loforte, Antonio, Lolong, Navy, Loon, Leong Chee, Lopes, Diogo, Lopez-Colon, Dalia, Loschner, Anthony L., Loubet, Paul, Loufti, Bouchra, Louis, Guillame, Lourenco, Silvia, Lovelace-Macon, Lara, Lee Low, Lee, Lowik, Marije, Loy, Jia Shyi, Lucet, Jean Christophe, Luna, Carlos M., Lungu, Olguta, Lunn, Miles, Luong, Liem, Luque, Nestor, Luton, Dominique, Maasikas, Olavi, Machado, Moïse, Machado, Sara, Macheda, Gabriel, Magzoub, Mustafa, Mahieu, Rafael, Mahy, Sophie, Maia, Ana Raquel, Maier, Lars S., Ascofare, Oumou Maiga, Maillet, Mylène, Maitre, Thomas, Majeed, Nimisha Abdul, Malfertheiner, Maximilian, Malik, Nadia, Mallon, Paddy, Maltez, Fernando, Malvy, Denis, Manda, Victoria, Mandelbrot, Laurent, Manetta, Frank, Mankikian, Julie, Manning, Edmund, Manuel, Aldric, Maráczi, Veronika, Sant′Ana Malaque, Ceila Maria, Marino, Flávio, Markowicz, Samuel, Marques, Ana, Marquis, Catherine, Marsh, Laura, Marsh, Brian, Marshal, Megan, Marshall, John, Martelli, Celina Turchi, Martin, Dori-Ann, Martin, Emily, Martin-Blondel, Guillaume, Martinelli, Alessandra, Martinez, F. Eduardo, Martin-Loeches, Ignacio, Martinot, Martin, Martín-Quiros, Alejandro, Martins, Ana, Martins, João, Martins, Nuno, Rego, Caroline Martins, Martucci, Gennaro, Martynenko, Olga, Marwali, Eva Miranda, Marzukie, Marsilla, Maslove, David, Mason, Sabina, Masood, Sobia, Masoud, Fatma, Massoma, Moise, Masumbe, Palmer, Mat Nor, Mohd Basri, Matan, Moshe, Fernandes, Henrique Mateus, Mathew, Meghena, Mathew, Christina, Mattei, Mathieu, Maulin, Laurence, May, Juergen, Maynar, Javier, Mayxay, Mayfong, Mazzoni, Thierry, Sweeney, Lisa Mc, McArthur, Colin, McCann, Naina, McCanny, Peter, McCarthy, Aine, McCarthy, Anne, McCloskey, Colin, McConnochie, Rachael, McDermott, Sherry, McDonald, Sarah E., McElroy, Aine, McElwee, Samuel, McEvoy, Natalie, McGeer, Allison, McLean, Kenneth A., McNally, Paul, McNicholas, Bairbre, Meaney, Edel, Mear-Passard, Cécile, Mechlin, Maggie, Medombou, Nastia, Mehkri, Omar, Mele, Ferruccio, Melo, Luis, Memon, Kashif Ali, Mendes, João João, Menkiti, Ogechukwu, Menon, Kusum, Mentré, France, Mentzer, Alexander J., Mercier, Emmanuelle, Mercier, Noémie, Merckx, Antoine, Mergeay-Fabre, Mayka, Mergler, Blake, Merson, Laura, Mesquita, António, Meta, Roberta, Metwally, Osama, Meybeck, Agnès, Meyer, Dan, Meynert, Alison M., Meysonnier, Vanina, Mezidi, Mehdi, Michelanglei, Céline, Michelet, Isabelle, Mihelis, Efstathia, Mihnovit, Vladislav, Abdullah, Duha Milad, Miller, Jennene, Miranda-Maldonado, Hugo, Misnan, Nor Arisah, Eliza Mohamed, Nik Nur, Mohamed, Nouralsabah, Mohamed, Tahira Jamal, Ads, Alaa Mohamed, Mohamed Elsayed Abdelhalim, Ahmed Reda, Mohammed, Libya, Mohammed Mostafa, Shrouk Fawze, Abdelrahman Mohammedahmed, Manahil Omer, Mohammedelhassan, Omer Abdullah, Moin, Asma, Mokhtar, Walaa, Molinos, Elena, Molloy, Brenda, Mone, Mary, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Sarah, Moore, Shona C., Cely, Lina Morales, Morgom, Marwa, Moro, Lucia, Motherway, Catherine, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mualla, Suleiman Haitham, Muftah, Mohamed, Mufti, Aisha Kalsoom, Muh, Ng Yong, Muhaisen, Mo'nes, Muhamad, Dzawani, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Munblit, Daniel, Ali, Syed Muneeb, Munir, Nadeem, Munshi, Laveena, Murphy, Aisling, Murray, Patrick, Murris, Marlène, Murthy, Srinivas, Musaab, Himed, Mustafa, Alamin, Mustafa, Mus'ab, Mustafa, Dana, Muvindi, Himasha, Myrodia, Dimitra Melia, Mohd-Hanafiah, Farah Nadia, Nadjm, Behzad, Nagpal, Dave, Nagrebetsky, Alex, Nagybányai-Nagy, Blanka, Boudoin, Herwin Nanda, Narasimhan, Mangala, Narayanan, Nageswaran, Nasa, Prashant, Khan, Rashid Nasim, Nasrallah, Ahmad, Nassif Metri, Adel Gerges, Nazerali-Maitland, Alasdair, Neant, Nadège, Neb, Holger, Nekliudov, Nikita, Nelder, Matthew, Nelwan, Erni, Neto, Raul, Neumann, Emily, Ng, Wing Yiu, Ng, Pauline Yeung, Nghi, Anthony, Nguyen, Duc, Choileain, Orna Ni, Leathlobhair, Niamh Ni, Niba, Nerissa, Nichol, Alistair D., Nitayavardhana, Prompak, Nonas, Stephanie, Mohd Noordin, Nurul Amani, Izzati Norharizam, Nurul Faten, North, Anita, Notari, Alessandra, Noursadeghi, Mahdad, Nowinski, Adam, Nseir, Saad, Numfor, Leonard, Nurnaningsih, Nurnaningsih, Nusantara, Dwi Utomo, Nyamankolly, Elsa, Nygaard, Anders Benteson, Brien, Fionnuala O., Callaghan, Annmarie O., O'Callaghan, Annmarie, Occhipinti, Giovanna, OConnor, Derbrenn, O'Donnell, Max, Ofori-Boadu, Lawrence, Ogston, Tawnya, Ogura, Takayuki, Oh, Tak-Hyuk, O'Halloran, Sophie, O'Hearn, Katie, Ohene, Sally-Ann, Ohshimo, Shinichiro, Oliveira, João, Oliveira, Larissa, Olliaro, Piero L., Rageh Elnaggar, Cinderella Omar, Mohammed Omer, Alsarrah Ali, Ondobo, Pierre, Ong, David S.Y., Ong, Jee Yan, Oosthuyzen, Wilna, Opavsky, Anne, Openshaw, Peter, Orakzai, Saijad, Orozco-Chamorro, Claudia Milena, Ortoleva, Jamel, Elsayed Soliman, Mohamed Osama, Osatnik, Javier, O'Shea, Linda, O'Sullivan, Miriam, Othman, Eman, Othman, Siti Zubaidah, Ouamara, Nadia, Ouissa, Rachida, Owusu, Micheal, Owusu-Asare, Ama Akyampomaa, Oziol, Eric, Pagadoy, Maïder, Pages, Justine, Palacios, Amanda, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Paneru, Hem, Pang, Lai Hui, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parke, Rachael, Parker, Melissa, Pasquier, Jérémie, Pastene, Bruno, Patauner, Fabian, Patel, Drashti, Pathmanathan, Mohan Dass, Patrão, Luís, Patricio, Patricia, Patterson, Lisa, Pattnaik, Rajyabardhan, Paul, Christelle, Paul, Mical, Paulos, Jorge, Paxton, William A., Payen, Jean-François, Peake, Sandra L., Peariasamy, Kalaiarasu, Peek, Giles J., Peelman, Florent, Peiffer-Smadja, Nathan, Peigne, Vincent, Pejkovska, Mare, Pelosi, Paolo, Peltan, Ithan D., Pereira, Rui, Perez, Daniel, Perpoint, Thomas, Pesenti, Antonio, Pestre, Vincent, Petrou, Lenka, Petrovic, Michele, Petrov-Sanchez, Ventzislava, Pettersen, Frank Olav, Peytavin, Gilles, Philips, Richard Odame, Phonemixay, Ooyanong, Phoutthavong, Soulichanya, Piagnerelli, Michael, Picard, Walter, Picone, Olivier, de Piero, Maria, Piersma, Djura, Pimentel, Carlos, Pinto, Raquel, Pires, Catarina, Piroth, Lionel, Pitaloka, Ayodhia, Piubelli, Chiara, Pius, Riinu, Piva, Simone, Plantier, Laurent, Png, Hon Shen, Poissy, Julien, Pokeerbux, Ryadh, Poli, Sergio, Pollakis, Georgios, Ponscarme, Diane, Porto, Diego Bastos, Post, Andra-Maris, Postma, Douwe F., Povoa, Pedro, Póvoas, Diana, Powis, Jeff, Prapa, Sofia, Praphasiri, Viladeth, Preau, Sébastien, Prebensen, Christian, Preiser, Jean-Charles, Prinssen, Anton, Pritchard, Mark G., Dilanthi Priyadarshani, Gamage Dona, Proença, Lucia, Pudota, Sravya, Semedi, Bambang Pujo, Pulicken, Mathew, Puplampu, Peter, Purcell, Gregory, Quesada, Luisa, Quinones-Cardona, Vilmaris, Quist-Paulsen, Else, Quraishi, Mohammed, Qutishat, Fadi, Rabaa, Maia, Rabaud, Christian, Rabindrarajan, Ebenezer, Rafael, Aldo, Rafiq, Marie, Ragab, Abdelrahman, Rahardjani, Mutia, Ullah, Arslan Rahat, Haji Ab Rahman, Ahmad Kashfi, Rahman, Rozanah Abd, Rainieri, Fernando, Rajahram, Giri Shan, Ramachandran, Pratheema, Ramakrishnan, Nagarajan, Ramalho, José, Ramli, Ahmad Afiq, Rammaert, Blandine, Ramos, Grazielle Viana, Rana, Asim, Rangappa, Rajavardhan, Ranjan, Ritika, Rapp, Christophe, Rashan, Aasiyah, Rashan, Thalha, Rasheed, Ghulam, Rasmin, Menaldi, Rätsep, Indrek, Rau, Cornelius, Ravi, Tharmini, Raza, Ali, Real, Andre, Rebaudet, Stanislas, Redl, Sarah, Reeve, Brenda, Rehman, Attaur, Rehman Khalid, Muhammad Osama, Reikvam, Dag Henrik, Reis, Renato, Rello, Jordi, Remppis, Jonathan, Remy, Martine, Ren, Hongru, Renk, Hanna, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Luis Felipe, Ribeiro, Maria Ines, Ricchiuto, Antonia, Richardson, David, Richardson, Denise, Richier, Laurent, Atikah Ahmad Ridzuan, Siti Nurul, Rios, Ana L., Rishu, Asgar, Rispal, Patrick, Risso, Karine, Rivera Nuñez, Maria Angelica, Robba, Chiara, Roberto, André, Roberts, Stephanie, Roberts, Charles, Robertson, David L., Robineau, Olivier, Roca, Anna, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, Roessler, Bernhard, Roger, Claire, Roger, Pierre-Marie, Rojek, Amanda, Roncon-Albuquerque, Roberto, Jr., Roriz, Mélanie, Rosa-Calatrava, Manuel, Rose, Michael, Rosenberger, Dorothea, Rossanese, Andrea, Rossetti, Matteo, Rossignol, Patrick, Roy, Carine, Roze, Benoît, Rusmawatiningtyas, Desy, Russell, Clark D., Ryan, Maeve, Ryckaert, Steffi, Holten, Aleksander Rygh, Saba, Isabela, Sadaf, Sairah, Sadat, Musharaf, Sahraei, Valla, Said, Abdurraouf, Saidani, Nadia, Sakiyalak, Pranya, Sako, Fodé Bangaly, Salah, Moamen, Salah Eldin Mohamed Abbas, Ali Alaa, Salahuddin, Nawal, Salazar, Leonardo, Saleem, Jodat, Alyasiri, Mohammed Saleh, Abu Salem, Talat Ahmed, Sales, Gabriele, Gandonniere, Charlotte Salmon, Salvator, Hélène, Samardali, Dana, Samardali, Shaden, Shaaban Aly Orabi, Yehia Samir, Sanchez, Emely, Sanchez, Olivier, Sanchez de Oliveira, Kizy, Sanchez-Miralles, Angel, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandhu, Zulfiqar, Sandrine, Pierre-François, Săndulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Banheiro, Bruno Sarmento, Sarmiento, Iam Claire E., Sarton, Benjamine, Satya, Ankana, Satyapriya, Sree, Satyawati, Rumaisah, Saviciute, Egle, Saw, Yen Tsen, Schaffer, Justin, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schnur, János, Schroll, Stephan, Schwameis, Michael, Schwartz, Gary, Scott, Janet T., Scott-Brown, James, Sedillot, Nicholas, Seitz, Tamara, Selvanayagam, Jaganathan, Selvarajoo, Mageswari, Semple, Malcolm G., Senian, Rasidah Bt, Senneville, Eric, Sepulveda, Claudia, Sequeira, Filipa, Sequeira, Tânia, Neto, Ary Serpa, Shadowitz, Ellen, Shahidan, Syamin Asyraf, Shahla, Hamza, Shalabi, Laila, Shames, Haitam, Shankar, Anuraj, Sharjeel, Shaikh, Sharma, Pratima, Shaw, Catherine A., Shaw, Victoria, Sheenan, John Robert, Mohan Shetty, Dr. Rajesh, Shetty, Rohan, Shiekh, Mohiuddin, Shime, Nobuaki, Shimizu, Keiki, Shrapnel, Sally, Shrestha, Shubha Kalyan, Shrestha, Pramesh Sundar, Shum, Hoi Ping, Mohammed, Nassima Si, Siang, Ng Yong, Siaw-Frimpong, Moses, Sibiude, Jeanne, Sibounheuang, Bountoy, Siddig, Nidhal, Siddiqui, Atif, Siddiqui, Maqsood Ahmed, Sigfrid, Louise, Sillah, Fatoumata, Sillaots, Piret, Silva, Catarina, Silva, Maria Joao, Silva, Rogério, Lim Heng, Benedict Sim, Sin, Wai Ching, Sinatti, Dario, Singh, Mahendra, Singh, Punam, Sitompul, Pompini Agustina, Sivam, Karisha, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Coilin, Snacken, Morgane, So, Dominic, Soh, Tze Vee, Solberg, Lene Bergendal, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnès, Song, Myung Jin, Song, Rima, Song, Tae, Chia, Jack Song, Søraas, Arne, Sotto, Albert, Soum, Edouard, Sousa, Ana Chora, Sousa, Marta, Uva, Maria Sousa, Souza-Dantas, Vicente, Sow, Mamadou Saliou, Sperry, Alexandra, Spinuzza, Elisabetta, Ruwan Sri Darshana, B. P. Sanka, Sriskandan, Shiranee, Stabler, Sarah, Staudinger, Thomas, Stecher, Stephanie-Susanne, Steinsvik, Trude, Stienstra, Ymkje, Stiksrud, Birgitte, Stolz, Eva, Stone, Amy, Streinu-Cercel, Anca, Streinu-Cercel, Adrian, Strong, Geoff, Stuart, Ami, Stuart, David, Su, Richa, Subekti, Decy, Suen, Gabriel, Suen, Jacky Y., Sukumar, Prasanth, Sultana, Asfia, Summers, Charlotte, Supic, Dubravka, Suppiah, Deepashankari, Surovcová, Magdalena, Suwarti, Atie, Svistunov, Andrey, Syahrin, Sarah, Sylverken, Augustina, Syrigos, Konstantinos, Sztajnbok, Jaques, Szuldrzynski, Konstanty, Tabrizi, Shirin, Taccone, Fabio S., Tagherset, Lysa, Taib, Shahdattul Mawarni, Taleb, Sara, Talla, Cheikh, Talsma, Jelmer, Tamisier, Renaud, Tampubolon, Maria Lawrensia, Tan, Kim Keat, Tan, Yan Chyi, Tanaka, Hiroyuki, Tanaka, Taku, Taniguchi, Hayato, Taqdees, Huda, Taqi, Arshad, Tardivon, Coralie, Kamal Mostafa, Yousef Tarek, Tarhabat, Ali, Tattevin, Pierre, Taufik, M Azhari, Tawfik, Hassan, Tee, Tze Yuan, Teixeira, João, Tejada, Sofia, Tellier, Marie-Capucine, Teoh, Sze Kye, Teotonio, Vanessa, Téoulé, François, Terrier, Olivier, Terzi, Nicolas, Tessier-Grenier, Hubert, Tey, Adrian, Mohd Thabit, Alif Adlan, Thakur, Anand, Tham, Zhang Duan, Thangavelu, Suvintheran, Theron, Elmi, Thibault, Vincent, Thiberville, Simon-Djamel, Thill, Benoît, Thirumanickam, Jananee, Thompson, Niamh, Thompson, Shaun, Thomson, Emma C., Thomson, David, Thorpe, Mathew, Thurai, Surain Raaj Thanga, Thwaites, Ryan S., Tierney, Paul, Tieroshyn, Vadim, Timashev, Peter S., Timsit, Jean-François, Tirupakuzhi Vijayaraghavan, Bharath Kumar, Tissot, Noémie, Toal, Fiona, Yang Toh, Jordan Zhien, Toki, Maria, Tonby, Kristian, Tonnii, Sia Loong, Torre, Marta, Torres, Antoni, Torres, Margarida, Santos-Olmo, Rosario Maria Torres, Torres-Zevallos, Hernando, Tounkara, Aboubacar, Towers, Michael, Traoré, Fodé Amara, Trapani, Tony, Tromeur, Cécile, Trontzas, Ioannis, Trouillon, Tiffany, Truong, Jeanne, Tual, Christelle, Tubiana, Sarah, Tuite, Helen, Turgeon, Alexis F., Turmel, Jean-Marie, Turtle, Lance C.W., Tveita, Anders, Twardowski, Pawel, Uchiyama, Makoto, Udayanga, PG Ishara, Udy, Andrew, Ullrich, Roman, Uribe, Alberto, Usman, Asad, Usuf, Effua, Uyeki, Timothy M., Vajdovics, Cristinava, Valentini, Piero, Val-Flores, Luís, Van de Velde, Stijn, van den Berge, Marcel, van der Feltz, Machteld, van der Palen, Job, van der Valk, Paul, Van Der Vekens, Nicky, Van der Voort, Peter, Van Der Werf, Sylvie, van Gulik, Laura, Van Hattem, Jarne, van Netten, Carolien, van Veen, Ilonka, Vanel, Noémie, Vanoverschelde, Henk, Varrone, Michael, Vasudayan, Shoban Raj, Vauchy, Charline, Vecham, Pavan Kumar, Veeran, Shaminee, Veislinger, Aurélie, Vencken, Sebastian, Ventura, Sara, Verbon, Annelies, Vidal, José Ernesto, Vieira, César, Vijayan, Deepak, Villar, Judit, Villeneuve, Pierre-Marc, Villoldo, Andrea, Vishwanathan, Gayatri, Visseaux, Benoit, Visser, Hannah, Vitiello, Chiara, Vongsouvath, Manivanh, Vonkeman, Harald, Vuotto, Fanny, Wahab, Suhaila Abdul, Wahab, Noor Hidayu, Wahid, Nadirah Abdul, Wainstein, Marina, Walsh, Laura, Shukeri, Wan Fadzlina Wan Muhd, Wang, Chih-Hsien, Webb, Steve, Wei, Jia, Weil, Katharina, Wen, Tan Pei, Wesam, Hassi, Wesselius, Sanne, West, T. Eoin, Wham, Murray, Whelan, Bryan, White, Nicole, Wicky, Paul Henri, Wiedemann, Aurélie, Wijaya, Surya Otto, Wille, Keith, Willems, Sue, Williams, Bailey, Williams, Patricia J., Williams, Virginie, Wils, Evert-Jan, Wittman, Jessica, Wong, Calvin, Wong, Xin Ci, Wong, Yew Sing, Wong, Teck Fung, Wright, Natalie, Xian, Lim Saio, Xynogalas, Ioannis, Binti Mohd Yakop, Siti Rohani, Yamazaki, Masaki, Yarad, Elizabeth, Yazdanpanah, Yazdan, Hing, Nicholas Yee Liang, Mahmoud Abdelaal, Abdelrahman Yehia, Yelnik, Cécile, Yeoh, Chian Hui, Yerkovich, Stephanie, Yiaye, Touxiong, Yokoyama, Toshiki, Yonis, Hodane, Yousif, Obada, Yuliarto, Saptadi, Zaaqoq, Akram, Zabbe, Marion, Zabert, Gustavo E., Zacharowski, Kai, Zahid, Masliza, Zahran, Maram, Binti Zaidan, Nor Zaila, Zambon, Maria, Zambrano, Miguel, Zanella, Alberto, Zaynah, Nurul, Zayyad, Hiba, Zoufaly, Alexander, Zucman, David, Ibáñez-Prada, Elsa D., Gonçalves, Bronner P., Baruch, Joaquin, Escher, Martina, Philippy, Fred, Kutsogiannis, Demetrios James, Vaillant, Michel, and Olliaro, Piero

Published
2024
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32. Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Author

Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, and Timo D. Müller

Subjects
Obesity, Type 2 diabetes, GIP, GLP-1, GIPR:GLP-1R co-agonism, Internal medicine, RC31-1245
Abstract

Objective: The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether GIP regulates body weight and glucose control via GIPR signaling in cells that express the leptin receptor (Lepr). Methods: Hypothalamic, hindbrain, and pancreatic co-expression of Gipr and Lepr was assessed using single cell RNAseq analysis. Mice with deletion of Gipr in Lepr cells were generated and metabolically characterized for alterations in diet-induced obesity (DIO), glucose control and leptin sensitivity. Long-acting single- and dual-agonists at GIPR and GLP-1R were further used to assess drug effects on energy and glucose metabolism in DIO wildtype (WT) and Lepr-Gipr knock-out (KO) mice. Results: Gipr and Lepr show strong co-expression in the pancreas, but not in the hypothalamus and hindbrain. DIO Lepr-Gipr KO mice are indistinguishable from WT controls related to body weight, food intake and diet-induced leptin resistance. Acyl-GIP and the GIPR:GLP-1R co-agonist MAR709 remain fully efficacious to decrease body weight and food intake in DIO Lepr-Gipr KO mice. Consistent with the demonstration that Gipr and Lepr highly co-localize in the endocrine pancreas, including the β-cells, we find the superior glycemic effect of GIPR:GLP-1R co-agonism over single GLP-1R agonism to vanish in Lepr-Gipr KO mice. Conclusions: GIPR signaling in cells/neurons that express the leptin receptor is not implicated in the control of body weight or food intake, but is of crucial importance for the superior glycemic effects of GIPR:GLP-1R co-agonism relative to single GLP-1R agonism.

Published
2024
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34. School independence day event focuses on true values

Author

Ahmed, Khalil

Subjects
Holidays -- Rites, ceremonies and celebrations, School principals -- Interviews, Business, international
Abstract

Byline: Khalil Ahmed Interview with Mr. Adnan Ghaffar - Principal at The Aura School PAGE: Tell me something about yourself and your school, please: Adnan Ghaffar: I work as the [...]

Published
2024

35. Pakistani institutions lead with global standards

Author

Ahmed, Khalil

Subjects
Finance -- Educational aspects, Accounting -- Educational aspects, College teachers -- Interviews, Business, international
Abstract

Byline: Khalil Ahmed Interview with Mr. Farhan Saeed - a renowned faculty member PAGE: Tell me something about yourself, please: Farhan Saeed: I am an educationist by profession; have invested [...]

Published
2024

36. Education system poised for growth

Author

Ahmed, Khalil

Subjects
Educational services industry -- Growth, College teachers -- Interviews, Company growth, Business, international
Abstract

Byline: Khalil Ahmed Interview with Syed Kashif Rafi - Registrar and Director, International Linkages and Opportunities, ILMA University PAGE: Tell me something about yourself, please: Syed Kashif Rafi: For the [...]

Published
2024

37. Budget 2024-25: pathway to prosperity

Author

Ahmed, Khalil

Subjects
Pakistan -- Economic policy, Fiscal policy -- Evaluation, National budgets -- Management, Company business management, Business, international
Abstract

Byline: KHALIL AHMED With a distinguished career exceeding three decades, Mohammad Iqbal Ghori has made significant contributions both to the public and private sectors of Pakistan, marking the commencement of [...]

Published
2024

38. Budget must be visionary and practical

Author

Ahmed, Khalil

Subjects
Pakistan -- Economic policy, Tax rates -- Statistics, National budgets -- Laws, regulations and rules, Government regulation, Business, international
Abstract

Byline: KHALIL AHMED Majyd Aziz: I am Former President of Karachi Chamber of Commerce and Industry, Employers' Federation of Pakistan, South Asian Forum of Employers, (UN) Global Compact Network Pakistan, [...]

Published
2024

39. Budget aims to foster sustainable growth

Author

Ahmed, Khalil

Subjects
Sustainable development -- Evaluation, Economic growth -- Environmental aspects, National budgets -- Management, Company business management, Business, international
Abstract

Byline: KHALIL AHMED Mr Zia Ul Mustafa Awan is a Chartered Management Accountant from ICMA Pakistan with more than 25 years of experience in corporate and public sector in leading [...]

Published
2024

41. Sleep disorders linked to quality of life in a sample of Egyptian policemen a comparative study between shift workers and non-shift workers

Author

Rehab Mohamed Naguib, Abdel Nasser Mahmoud Omar, Naglaa Mohamed ElKhayat, Sherien Ahmed Khalil, Mostafa Ahmed Mohamed Kotb, and Lobna Azzam

Subjects
Sleep, Shift work, Occupational, Occupational stress, Police officers, Quality of life, Psychiatry, RC435-571
Abstract

Abstract Background Poor sleep is associated with bad health outcomes, worse well-being and decreases in performance, productivity and safety at work. Police officers are exposed to several risk factors including extended work schedules, shift work, occupational stress, dangerous and traumatic events and can, as such, develop sleep problems. So, this study aimed to compare quality of life, occupational stress level, between shift and non-shift workers’ policemen working at El-Agouza Police Hospital. This was a cross-sectional comparative study conducted on 64 policemen working in 6 different Police department recruited from sleep clinic neuropsychiatry department at EL-Agouza Police Hospital serving police officers in El-Nile Street, Giza, Egypt. The total included cases were classified to two groups: group I (shift workers) included 32 of shift workers who provide service across, all 24 h of the clock each day of the week (often abbreviated as 24/7), group II (non-shift workers): included 32 of non-shift workers. Results Occurrence of sleep disorders was significantly higher in the shift workers compared to the non-shift worker group (p

Published
2023
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45. GFRP-Reinforced Concrete Columns: State-of-the-Art, Behavior, and Research Needs

Author

Mohamed Elkafrawy, Prathibha Gowrishankar, Nour Ghazal Aswad, Adnan Alashkar, Ahmed Khalil, Mohammad AlHamaydeh, and Rami Hawileh

Subjects
columns, compression, glass fiber-reinforced polymer (GFRP), Reinforced Concrete (RC), structural behavior, Building construction, TH1-9745
Abstract

This comprehensive review paper delves into the utilization of Glass Fiber-Reinforced Polymer (GFRP) composites within the realm of concrete column reinforcement, spotlighting the surge in structural engineering applications that leverage GFRP instead of traditional steel to circumvent the latter’s corrosion issues. Despite a significant corpus of research on GFRP-reinforced structural members, questions about their compression behavior persist, making it a focal area of this review. This study evaluates the properties of GFRP bars and their impact on the structural behavior of concrete columns, addressing variables such as concrete type and strength, cross-sectional geometry, slenderness ratio, and reinforcement specifics under varied loading protocols. With a dataset spanning over 250 publications from 1988 to 2024, our findings reveal a marked increase in research interest, particularly in regions like China, Canada, and the United States, highlighting GFRP’s potential as a cost-effective and durable alternative to steel. However, gaps in current knowledge, especially concerning Ultra-High-Performance Concrete (UHPC) reinforced with GFRP, underscore the necessity for targeted research. Additionally, the contribution of GFRP rebars to compressive column capacity ranges from 5% to 40%, but current design codes and standards underestimate this, necessitating new models and design provisions that accurately reflect GFRP’s compressive behavior. Moreover, this review identifies other critical areas for future exploration, including the influence of cross-sectional geometry on structural behavior, the application of GFRP in seismic resistance, and the evaluation of the size effect on column strength. Furthermore, the paper calls for advanced studies on the long-term durability of GFRP-reinforced structures under various environmental conditions, environmental and economic impacts of GFRP usage, and the potential of Artificial Intelligence (AI) and Machine Learning (ML) in predicting the performance of GFRP-reinforced columns. Addressing these research gaps is crucial for developing more resilient and sustainable concrete structures, particularly in seismic zones and harsh environmental conditions, and fostering advancements in structural engineering through the adoption of innovative, efficient construction practices.

Published
2024
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46. Recent Advancements in Geothermal Energy Piles Performance and Design

Author

Ahmed Khalil, Mousa Attom, Zahid Khan, Philip Virgil Astillo, and Oussama M. El-Kadri

Subjects
sustainable energy, geothermal systems, energy pile design, ground heat exchange, thermomechanical behavior, renewable energy solutions, Technology
Abstract

Geothermal energy piles or ground heat exchange (GHE) systems embrace a sustainable source of energy that utilizes the geothermal energy naturally found inside the ground in order to heat and/or cool buildings. GHE is a highly innovative system that consists of energy loops within foundation elements (shallow foundations or piles) through which a heat carrier fluid circulates, enabling heat extraction or storage in the ground. Despite the innovation and potential of GHE systems, there are significant challenges in harmonizing their thermal and mechanical designs due to the complex interactions involved. This review critically examines state-of-the-art design methodologies developed to address these complexities, providing insights into the most recent advancements in GHE performance and design. Key findings include innovative techniques such as advanced numerical modeling to predict thermomechanical behavior, the use of different pipe configurations to optimize heat transfer, and strategies to minimize thermal stress on the foundation. Additionally, this review identifies research gaps, including the need for more comprehensive full-scale experimental validations, the impact of soil properties on system performance, and the long-term effects of thermal cycling on pile integrity. These insights aim to contribute to a better understanding of the thermomechanical behavior of energy piles, ultimately facilitating more accurate and effective design solutions.

Published
2024
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47. Early radiologic and metabolic tumour response assessment during combined chemo-radiotherapy for locally advanced NSCLC

Author

Marie Tvilum, Marianne Marquard Knap, Lone Hoffmann, Azza Ahmed Khalil, Ane L. Appelt, Ate Haraldsen, Markus Alber, Cai Grau, Hjørdis Hjalting Schmidt, Maria Kandi, Marianne Ingerslev Holt, Christina Maria Lutz, and Ditte Sloth Møller

Subjects
Non-small cell lung cancer, Early treatment response, Pattern of failure, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: The role of early treatment response for patients with locally advanced non-small cell lung cancer (LA-NSCLC) treated with concurrent chemo-radiotherapy (cCRT) is unclear. The study aims to investigate the predictive value of response to induction chemotherapy (iCX) and the correlation with pattern of failure (PoF). Materials and methods: Patients with LA-NSCLC treated with cCRT were included for analyses (n = 276). Target delineations were registered from radiotherapy planning PET/CT to diagnostic PET/CT, in between which patients received iCX. Volume, sphericity, and SUVpeak were extracted from each scan. First site of failure was categorised as loco-regional (LR), distant (DM), or simultaneous LR+M (LR+M). Fine and Gray models for PoF were performed: a baseline model (including performance status (PS), stage, and histology), an image model for squamous cell carcinoma (SCC), and an image model for non-SCC. Parameters included PS, volume (VOL) of tumour, VOL of lymph nodes, ΔVOL, sphericity, SUVpeak, ΔSUVpeak, and oligometastatic disease. Results: Median follow-up was 7.6 years. SCC had higher sub-distribution hazard ratio (sHR) for LRF (sHR = 2.771 [1.577:4.87], p

Published
2024
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48. Parliamentary question: Insights from the Federal National Council in the UAE

Author

Tarek Abo El-Wafa, Ahmed Khalil, and Adham Hashish

Subjects
Parliamentary question, Federal national council (FNC), United Arab Emirates (UAE), Constitution, Procedures, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

This paper highlights the paramount role of parliamentary questioning as a control mechanism exercised by the Federal National Council (FNC) in the United Arab Emirates (UAE). The surge in its utilization, attributed to heightened awareness among FNC members and ministers, has significantly enhanced the Council's control capabilities, especially in the absence of alternative parliamentary control instruments such as interpellations. The paper underscores the simplicity and adaptability of parliamentary questioning, which spans diverse topics and addresses everyday state matters, rectifies errors, monitors law implementation, and fills legislative gaps. The structure of the paper comprises two sections: the first scrutinizes procedural requirements within the UAE's Constitution and the FNC's Bylaw, while the second section explores practical examples, offering insights into the distinctive nature of the FNC's parliamentary questioning compared to regional practices.

Published
2024
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49. Cybersecurity in Motion: A Survey of Challenges and Requirements for Future Test Facilities of CAVs

Author

Ioannis Mavromatis, Theodoros Spyridopoulos, Pietro Carnelli, Woon Hau Chin, Ahmed Khalil, Jennifer Chakravarty, Lucia Cipolina Kun, Robert J. Piechocki, Colin Robbins, Daniel Cunnington, Leigh Chase, Lamogha Chiazor, Chris Preston, Rahul, and Aftab Khan

Subjects
C-ITS, Cybersecurity, CAV, Cybersecurity Centre of Excellence, Cybersecurity Ecosystem, Threat Detection, Computer engineering. Computer hardware, TK7885-7895, Systems engineering, TA168
Abstract

The way we travel is changing rapidly and Cooperative Intelligent Transportation Systems (C-ITSs) are at the forefront of this evolution. However, the adoption of C-ITSs introduces new risks and challenges, making cybersecurity a top priority for ensuring safety and reliability. Building on this premise, this paper introduces an envisaged Cybersecurity Centre of Excellence (CSCE) designed to bolster researching, testing, and evaluating the cybersecurity of C-ITSs. We explore the design, functionality, and challenges of CSCE's testing facilities, outlining the technological, security, and societal requirements. Through a thorough survey and analysis, we assess the effectiveness of these systems in detecting and mitigating potential threats, highlighting their flexibility to adapt to future C-ITSs. Finally, we identify current unresolved challenges in various C-ITS domains, with the aim of motivating further research into the cybersecurity of C-ITSs.

Published
2024
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