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5. Video 1 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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6. Video 4 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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7. Data from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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8. Supplementary Information from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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9. Video 2 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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10. Video 3 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, primary, Ahmad, Syed F., primary, Hughes, Gareth, primary, Sheridan, Victoria, primary, Odedra, Rajesh, primary, Farrington, Paul, primary, Cadogan, Elaine B., primary, Riches, Lucy C., primary, Garcia-Trinidad, Antonio, primary, Thomason, Andrew G., primary, Patel, Bhavika, primary, Vincent, Jennifer, primary, Lau, Alan, primary, Pike, Kurt G., primary, Hunt, Thomas A., primary, Sule, Amrita, primary, Valerie, Nicholas C.K., primary, Biddlestone-Thorpe, Laura, primary, Kahn, Jenna, primary, Beckta, Jason M., primary, Mukhopadhyay, Nitai, primary, Barlaam, Bernard, primary, Degorce, Sebastien L., primary, Kettle, Jason, primary, Colclough, Nicola, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Barrett, Ian P., primary, Zheng, Li, primary, Zhang, Tianwei, primary, Wang, Yingchun, primary, Chen, Kan, primary, Pass, Martin, primary, Durant, Stephen T., primary, and Valerie, Kristoffer, primary

Published
2023
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11. CIRCULATING PROGENITOR CELL COUNT: AN INDEPENDENT BIOMARKER OF ADVERSE OUTCOMES IN CORONARY ARTERY DISEASE

Author

Mehta, Anurag, primary, Meng, Qi, additional, Ahmad, Syed F., additional, Ho, Annie, additional, Desai, Shivang, additional, Dhindsa, Devinder, additional, Zuniga, Joshua, additional, Islam, Shabatun, additional, Almuwaqqat, Zakaria, additional, Nayak, Aditi, additional, Sperling, Laurence S., additional, Waller, Edmund K., additional, and Quyyumi, Arshed A., additional

Published
2022
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12. Vascular Regenerative Capacity and the Obesity Paradox in Coronary Artery Disease

Author

Mehta, Anurag, primary, Meng, Qi, additional, Li, Xiaona, additional, Desai, Shivang R., additional, D’Souza, Melroy S., additional, Ho, Annie H., additional, Islam, Shabatun J., additional, Dhindsa, Devinder S., additional, Almuwaqqat, Zakaria, additional, Nayak, Aditi, additional, Alkhoder, Ayman A., additional, Hooda, Ananya, additional, Varughese, Anil, additional, Ahmad, Syed F., additional, Mokhtari, Ali, additional, Hesaroieh, Iraj, additional, Sperling, Laurence S., additional, Ko, Yi-An, additional, Waller, Edmund K., additional, and Quyyumi, Arshed A., additional

Published
2021
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14. Additional file 3 of B chromosomes of multiple species have intense evolutionary dynamics and accumulated genes related to important biological processes

Author

Ahmad, Syed F., Jehangir, Maryam, Adauto L. Cardoso, Wolf, Ivan R., Margarido, Vladimir P., Cabral-De-Mello, Diogo C., O’Neill, Rachel, Valente, Guilherme T., and Martins, Cesar

Abstract

Additional file 3: Figure S1. A workflow of steps applied in the present study during the procedure of genomics analyses of B chromosomes in different species. Figure S2. Coverage plots of B-blocks of A. correntinus with remarkable difference in the reads coverage between 0B and 1B samples. Figure S3. Coverage plots of B-blocks of A. flavolineata with remarkable difference in the reads coverage between 0B and 2B samples. Figure S4. Identification of B chromosome genomic blocks (A) and their repeats contents (B) in A. flavolineata. Figure S5. Identification of protein-coding genes located in B chromosomes of the A. mexicanus, using the number of mapped reads that map to the CDSs found in the transcriptome, in the 0B (X axis) and 2B (Y axis). Each dot represents a coding sequence with only those labeled that recorded the log2 greater than 1.5. The plot is limited for 800 mapped reads to optimize the visualizations. Figure S6. Identification of protein-coding genes located in B chromosomes of the A. correntinus, using the number of mapped reads that map to the CDSs found in the transcriptome, in the 0B (X axis) and 1B (Y axis). Each dot represents a coding sequence with only those labeled that recorded the log2 greater than 1. The plot is limited for 800 mapped reads to optimize the visualizations. Figure S7. Coverage plots of (representative) coding sequences detected on the B chromosome of A. mexicanus using Log base 2 ratio. Each plot compares the reads depth of the transcript between 0B and 2B. Figure S8. Coverage plots of (representative) coding sequences detected on the B chromosome of A. correntinus using Log base 2 ratio. Each plot compares the reads depth of the transcript between 0B and 1B. Figure S9. Coverage plots of (representative) coding sequences detected on the B chromosome of A. flavolineata using Log base 2 ratio. Each plot compares the reads depth of the transcripts between 0B and 2B. Figure S10. Double FISH mapping of candidate blocks in A. flavolineata. Each panel represents mapping of two distinct blocks (7 and 14 – See Supplementary Table S2) labeled with digoxigenin (block 7 in red) and biotin (block 14 in green). A scattered pattern of markings of block 7 can be observed for the B chromosomes (white arrows), whereas telomeric and centromeric associated signals of blocks 7 and 14 are obvious for different A and X chromosomes. Figure S11. The methylation profile of microB blocks in A. mexicanus. (A) Graph shows the number of Bisulphite reads analyzed with B blocks and alignments. (B) Pie chart represents percentage of B block methylated Cs in different contexts with the highest percent in CpGs regions. (C) Pie chart highlights the number of hypomethylated (less than 50% methylated Cs), unmethylated, highly methylated and hypermethylated (more than 90% methylated Cs) B chromosome blocks. (D) Bisuphite coverage plots of hypermethylated blocks are shown as examples. Refer to Supplementary datasets (excel) for a complete list of methylated blocks with methylation level. Figure S12. FISH mapping of 45S rDNA (red labeling) in A. mexicanus. The micro B is indicated with an arrow showing no sign of 45S rDNA. Figure S13. Synteny dotplot of whole genome aligments between de novo B+ assembly and reference masked (coding) genome of A. mexicanus. Figure S14. Violin plots show the distribution of length for various types of genomic rearrangements from 0 to 5000 bp range. Figure S15. Synteny dotplot (synmap version, unfiltered) of self alignments of B blocks (A. mexicanus). Figure S16. Synteny dotplot (synmap version, unfiltered) of self alignments of B blocks (A. correntinus). Figure S17. Synteny dotplot (synmap version, unfiltered) of self alignments of B blocks (A. flavolineata).

Published
2020
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15. Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment

Author

Ahmad, Syed F., Brown, Jeremy K., Campbell, Lisa L., Koscielniak, Magda, Oliver, Catriona, Wheelhouse, Nick, Entrican, Gary, McFee, Stuart, Wills, Gillian S., McClure, Myra O., Horner, Patrick J., Gaikoumelou, Sevasti, Lee, Kai F., Critchley, Hilary O.D., Duncan, W. Colin, and Horne, Andrew W.

Subjects
Biomedical Science Research Group, Integrins, animal structures, Integrin beta1/genetics, Chlamydia Infections/complications, Ectopic pregnancy, lcsh:Medicine, Gene Expression, Chlamydia trachomatis, Fallopian tube, Ectopic pregnancy, Chlamydia trachomatis, Integrins, embryo implantation, fallopian tube, Cell Line, Mice, Pregnancy, Fallopian Tubes/metabolism, Animals, Humans, Microbiology Research Group, Embryo Implantation, Fallopian Tubes, lcsh:R5-920, Integrin beta1, lcsh:R, Pregnancy, Tubal/etiology, 618 Gynecology, obstetrics, pediatrics & geriatrics, Epithelial Cells, Chlamydia Infections, Immunohistochemistry, Trophoblasts/metabolism, female genital diseases and pregnancy complications, Coculture Techniques, Epithelial Cells/metabolism, Trophoblasts, Disease Models, Animal, Health, RG Gynecology and obstetrics, Embryo implantation, embryonic structures, Reproductive health, Pregnancy, Tubal, Female, lcsh:Medicine (General), Research Paper
Abstract

Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is unclear. Successful intra-uterine embryo implantation is associated with increased expression of endometrial “receptivity” integrins (cell adhesion molecules). We examined integrin expression in Fallopian tubes of women with previous C. trachomatis infection, in mice experimentally infected with C. trachomatis, in immortalised human oviductal epithelial cells (OE-E6/E7) and in an in vitro model of human embryo attachment (trophoblast spheroid-OE-E6/7 cell co-culture). Previous exposure with C. trachomatis increased Fallopian tube/oviduct integrin-subunit beta-1 (ITGB1) in women and mice compared to controls. C. trachomatis increased OE-E6/E7 cell ITGB1 expression and promoted trophoblast attachment to OE-E6/E7 cells which was negated by anti-ITGB1-antibody. We demonstrate that infection with C. trachomatis increases tubal ITGB1 expression, predisposing to tubal embryo attachment and ectopic pregnancy., Graphical Abstract Unlabelled Image, Highlights • Integrin subunit beta 1 is increased in Fallopian tubes of women and mice with evidence of past exposure to C. trachomatis. • C. trachomatis increases integrin subunit beta 1 in oviductal epithelial cells and promotes trophoblast attachment. • Functional blockage of integrin subunit beta 1 abrogates the attachment of trophoblast to oviductal epithelial cells. We present exciting data, derived from a combination of ex-vivo, in-vivo and in-vitro models, to explain the mechanism behind the epidemiological association of past pelvic chlamydial infection and increased risk of tubal ectopic pregnancy. Our data demonstrate that past infection with C. trachomatis increases integrin subunit beta 1 expression in Fallopian tubes in women and in oviducts in mice. We also show that C. trachomatis promotes attachment in an embryo-surrogate co-culture tubal attachment model and that this effect is negated by functional blockage of the integrin subunit beta 1.

Published
2018

16. Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Author

Karlin, Jeremy, primary, Allen, Jasmine, additional, Ahmad, Syed F., additional, Hughes, Gareth, additional, Sheridan, Victoria, additional, Odedra, Rajesh, additional, Farrington, Paul, additional, Cadogan, Elaine B., additional, Riches, Lucy C., additional, Garcia-Trinidad, Antonio, additional, Thomason, Andrew G., additional, Patel, Bhavika, additional, Vincent, Jennifer, additional, Lau, Alan, additional, Pike, Kurt G., additional, Hunt, Thomas A., additional, Sule, Amrita, additional, Valerie, Nicholas C.K., additional, Biddlestone-Thorpe, Laura, additional, Kahn, Jenna, additional, Beckta, Jason M., additional, Mukhopadhyay, Nitai, additional, Barlaam, Bernard, additional, Degorce, Sebastien L., additional, Kettle, Jason, additional, Colclough, Nicola, additional, Wilson, Joanne, additional, Smith, Aaron, additional, Barrett, Ian P., additional, Zheng, Li, additional, Zhang, Tianwei, additional, Wang, Yingchun, additional, Chen, Kan, additional, Pass, Martin, additional, Durant, Stephen T., additional, and Valerie, Kristoffer, additional

Published
2018
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20. Integration of Bioinformatics and in vitroAnalysis Reveal Anti-leishmanial Effects of Azithromycin and Nystatin

Author

Jehangir, Irum, Ahmad, Syed F., Jehangir, Maryam, Jamal, Anwar, and Khan, Momin

Abstract

Background: Leishmaniasis is the major cause of mortality in under-developed countries. One of the main problems in leishmaniasis is the limited number of drug options, resistance and side effects. Such a situation requires to study the new chemical series with anti-leishmanial activity. Objective: To assess the anti-leishmanial activity of antibacterial and antifungal drugs. Methods: We have applied an integrative approach based on computational and in vitro methods to elucidate the efficacy of different antibacterial and antifungal drugs against Leishmania tropica (KWH23). Firstly these compounds were analyzed using in silico molecular docking. This analysis showed that the nystatin and azithromycin interacted with the active site amino acids of the target protein leishmanolysin. The nystatin, followed by azithromycin, produced the lowest binding energies indicating their inhibitive activity against the target. The efficacy of the docked drugs was further validated in vitro which showed that our bioinformatics based predictions completely agreed with experimental results. Stock solutions of drugs, media preparation and parasites cultures were performed according to the standard in-vitro protocol. Results: We found that the half maximal inhibitory concentration (IC50) value of dosage form of nystatin (10,000,00 U) and pure nystatin was 0.05701 μM and 0.00324 μM respectively. The IC50 value of combined azithromycin and nystatin (dosage and pure form) was 0.156 μg/ml and 0.0023 μg /ml (0.00248 μM) respectively. It was observed that IC50 value of nystatin is better than azithromycin and pure form of drugs had significant activity than the dosage form of drugs. Conclusion: From these results, it was also proven that pure drugs combination result is much better than all tested drugs results. The results of both in vitro and in silico studies clearly indicated that comparatively, nystatin is the potential candidate drug in combat against Leishmania tropica.

Published
2019
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26. Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment.

Author

Ahmad SF, Brown JK, Campbell LL, Koscielniak M, Oliver C, Wheelhouse N, Entrican G, McFee S, Wills GS, McClure MO, Horner PJ, Gaikoumelou S, Lee KF, Critchley HOD, Duncan WC, and Horne AW

Subjects
Animals, Cell Line, Chlamydia Infections microbiology, Coculture Techniques, Disease Models, Animal, Embryo Implantation, Epithelial Cells metabolism, Fallopian Tubes metabolism, Fallopian Tubes pathology, Female, Gene Expression, Humans, Immunohistochemistry, Integrin beta1 genetics, Mice, Pregnancy, Pregnancy, Tubal pathology, Trophoblasts metabolism, Chlamydia Infections complications, Chlamydia trachomatis, Integrin beta1 metabolism, Pregnancy, Tubal etiology, Pregnancy, Tubal metabolism
Abstract

Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is unclear. Successful intra-uterine embryo implantation is associated with increased expression of endometrial "receptivity" integrins (cell adhesion molecules). We examined integrin expression in Fallopian tubes of women with previous C. trachomatis infection, in mice experimentally infected with C. trachomatis, in immortalised human oviductal epithelial cells (OE-E6/E7) and in an in vitro model of human embryo attachment (trophoblast spheroid-OE-E6/7 cell co-culture). Previous exposure with C. trachomatis increased Fallopian tube/oviduct integrin-subunit beta-1 (ITGB1) in women and mice compared to controls. C. trachomatis increased OE-E6/E7 cell ITGB1 expression and promoted trophoblast attachment to OE-E6/E7 cells which was negated by anti-ITGB1-antibody. We demonstrate that infection with C. trachomatis increases tubal ITGB1 expression, predisposing to tubal embryo attachment and ectopic pregnancy., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2018
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