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Mouth cancer is the most frequent cancer of the head and neck in both older and younger people. Achyranthes aspera L. has been used in ethnotraditional and pharmacological applications since ancient times for a variety of disorders. This study was formulated to examine bioactive phenolic and flavonoid compounds from the ethanolic extract of Achyranthes aspera and their binding efficacy targeting growth factor receptors (GFRs) against mouth cancer through in silico molecular docking and simulation studies. Phytochemicals were investigated through the UHPLC technique. A molecular docking study was accomplished using docking software AutoDock 4.2, and MD simulation was executed through GROMACS software. Drug‐likeness, pharmacokinetics, and toxicity profiles of phytocompounds were evaluated using Molinspiration, Swiss ADME, OSIRIS Data Warrior tools, respectively. UHPLC analysis detected phenolics and flavonoids, viz., fisetin, rutin, and fumaric acid, which satisfied Lipinski's rule of five and pharmacokinetic properties. In molecular docking assessment, fisetin exhibited promising interactions with core targeted proteins VEGFR‐2 (B.E. = −8.30 kcal mol−1) and FGFR‐2 (B.E. = −7.64 kcal mol−1) of mouth cancer. Moreover, molecular dynamics simulation data demonstrated stable interactions with both VEGFR‐2 and FGFR‐2 proteins. This binding interaction and stability of A. aspera phytocompounds with therapeutic proteins might contribute to their therapeutic potential in mouth cancer management. [ABSTRACT FROM AUTHOR]

Garcinia indica, also referred to as kokum, is a plant that belongs to the Clusiaceae family, indigenous to the Gujarat, Western Ghats and the northeastern area of India. Each component of the plant possesses distinct benefits and uses. Kokum is commonly consumed as 'sharbat' within the India's Western Ghats region. It serves as sustenance, therapeutic agents, and nutraceuticals. It has been utilized in Ayurvedic and Siddha treatment since antiquity. It plays potential role as antiglycation, anticancer, antihistaminic, antiulcerogenic, cardioprotective, antibacterial, antiviral, antidepressant, hepatoprotective, anti-inflammatory and so on. These findings indicate that G. indica possesses the potential to function as a beneficial therapeutic agent for various ailments, corroborated by prior publications on the pharmacological effects of its isolated constituents. [ABSTRACT FROM AUTHOR]

The genome editing technology based on clustered regularly interspaced short palindromic repeats/CRISPR-associated protein- 9 (CRISPR/Cas9), is revolutionizing research, particularly in the context of human neurodegenerative disorders. This review examines recent advancements in CRISPR/Cas9 and its potential to address the protein misfolding mechanisms underlying these diseases. Proteins, the fundamental units of life, can misfold due to various changes, resulting in aggregation and contributing to devastating illnesses such as Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, and Huntington's disease. Understanding the pathology of these disorders and the methods used for their detection is vital for developing effective treatments. CRISPR/Cas9 offers a powerful tool for combating neurodegenerative disorders at the molecular level. Its groundbreaking gene-editing capabilities are advancing preclinical and animal studies, paving the way for potential human trials and innovative therapeutic strategies. This review explores the complex challenge of protein misfolding and highlights how CRISPR technology could provide a crucial breakthrough in the fight against neurodegenerative disorders. It offers a synthesis of CRISPR advancements for neurodegenerative disorders. However, it is essential to be aware of the review's limitations, including potential selection bias, the risk of oversimplification, and possible obsolescence in rapidly changing research fields. Despite these considerations, the transformative promise of CRISPR in understanding and potentially treating neurodegenerative diseases warrants continued research and thorough analysis. [ABSTRACT FROM AUTHOR]

Roots of Asparagus racemosus (Shatavari roots) have high contents of calcium, iron, vitamin C and a variety medicinally beneficial compounds i.e. saponins, flavonoids and polyphenols. Taking this fact into consideration the crude powder of dried A. racemosus roots was added in varying amounts (10 to 50 %) as one of the ingredients of maize chips (nachos). Sensory evaluation revealed the best acceptability of chips having 20 % of crude powder of A. racemosus roots. Nutritional analysis revealed that the Z. mays chips containing 20 % of crude powder of A. racemosus roots have low glycemic index, low fat content but have high calcium, iron and vitamin C suitable for persons having calcium and iron deficiencies. [ABSTRACT FROM AUTHOR]

Garcinia indica (commonly known as kokum in India) tree has several applications in the food and medicine industries. Since ancient times, kokum has been used in Ayurvedic medicine to treat a variety of ailments, including as dermatitis, diarrhea, dysentery, ear infections, and digestive problems. Plant parts like leaves, fruit and seeds have anticancer, antiulcer, antioxidant, antiglycation and antitumor properties. Presence of hydroxycitric acid, anthocyanins and garcinol has been found in fruits and seeds. The present review highlights the historical use, nutritional value, phytochemical componentsand confirmed pharmacological activities of kokum [ABSTRACT FROM AUTHOR]