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1. Accumulation of natural killer cells after hepatic artery embolisation in the midgut carcinoid syndrome

Author

Wängberg, B, Ahlman, H, Tylén, U, Nilsson, O, Hermodsson, S, and Hellstrand, K

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Immunology, Aetiology, 2.1 Biological and endogenous factors, Cancer, Cytotoxicity, Immunologic, Embolization, Therapeutic, Hepatic Artery, Humans, Intestinal Neoplasms, Killer Cells, Natural, Liver Neoplasms, Lymphocytes, Malignant Carcinoid Syndrome, Phenotype, NK CELLS, CARCINOID TUMORS, HEPATIC ARTERY EMBOLIZATION, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients.

Published
1995

2. Endokrine Tumoren des gastroenteropankreatischen Systems

Author

Ahlman, H., Arnold, R., Becker, H. D., Beyer, J., Kisker, O., Klöppel, G., Klose, K. J., Pies, U., Röher, H. D., Rothmund, R., Schneider, S., Simon, B., Simon, D., Stinner, B., Rothmund, M., Teichmann, R. K., Siewert, J. R., editor, Harder, F., editor, and Rothmund, Matthias, editor

Published
2000
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24. Rare functioning pancreatic endocrine tumors

Author

O'Toole D, Salazar R, Kaltsas G, Couvelard A, De Herder WW, Hyrdel R, Nikou G, Krenning E, Vullierme MP, Caplin M, Jensen R, Eriksson B, Ahlman H, Arnold R, Bechstein WO, Cadiot G, Christ E, Chung D, Delle Fave G, Falchetti A, Ferone D, Goretzki P, Gross D, Hochhauser D, Keleştimur F, Kianmanesh R, Knapp W, Knigge UP, Komminoth P, Körner M, Kos Kudła B, Kvols L, Kwekkeboom DJ, Lewington V, Lopes JM, Manfredi R, McNicol AM, Mitry E, Niederle B, Nilsson O, Öberg K, O'Connor J, Pauwels S, Pape UF, Pavel M, Perren A, Plöckinger U, Ramage J, Ricke J, Rindi G, Ruszniewski P, Sauvanet A, Scarpa A, Scoazec JY, Sevilla Garcia MI, Steinmüller T, Sundin A, Taal B, Van Cutsem E, Wiedenmann B, Wildi S, Yao JC, Zgliczynski S., FALCONI , MASSIMO, Internal Medicine, Radiology & Nuclear Medicine, O'Toole, D, Salazar, R, Falconi, Massimo, Kaltsas, G, Couvelard, A, De Herder, Ww, Hyrdel, R, Nikou, G, Krenning, E, Vullierme, Mp, Caplin, M, Jensen, R, Eriksson, B, Ahlman, H, Arnold, R, Bechstein, Wo, Cadiot, G, Christ, E, Chung, D, Delle Fave, G, Falchetti, A, Ferone, D, Goretzki, P, Gross, D, Hochhauser, D, Keleştimur, F, Kianmanesh, R, Knapp, W, Knigge, Up, Komminoth, P, Körner, M, Kos Kudła, B, Kvols, L, Kwekkeboom, Dj, Lewington, V, Lopes, Jm, Manfredi, R, Mcnicol, Am, Mitry, E, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, Pauwels, S, Pape, Uf, Pavel, M, Perren, A, Plöckinger, U, Ramage, J, Ricke, J, Rindi, G, Ruszniewski, P, Sauvanet, A, Scarpa, A, Scoazec, Jy, Sevilla Garcia, Mi, Steinmüller, T, Sundin, A, Taal, B, Van Cutsem, E, Wiedenmann, B, Wildi, S, Yao, Jc, and Zgliczynski, S.

Subjects
medicine.medical_specialty, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Humans, Neuroendocrine Tumors, Pancreatic Neoplasms, Biology, University hospital, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, medicine
Abstract

a Department of Gastroenterology, Beaujon Hospital, Clichy , France; b Department of Oncology, Institut Catala d’Oncologia, Barcelona , Spain; c Department of Surgery, Verona University, Verona , Italy; d Department of Endocrinology and Metabolism, Genimatas Hospital, Athens , Greece; e Department of Gastroenterology, Beaujon Hospital, Clichy , France; f Department of Endocrinology, Erasmus MC University, Rotterdam , The Netherlands; g Department of Internal Medicine, Martin University, Martin , Slovakia; h Department of Propaedeutic Internal Medicine, Laiko Hospital, Athens , Greece; i Department of Nuclear Medicine, Erasmus MC University, Rotterdam , The Netherlands; j Department of Gastroenterology, Beaujon Hospital, Clichy , France; k Department of Gastroenterology, Royal Free Hospital, London , UK; l Department of Cell Biology, National Institute of Health, Bethesda, Md. , USA; m Department of Endocrinology, University Hospital, Uppsala , Sweden

Published
2006

26. Pheochromocytoma: recommendations for clinical practice from the First International Symposium. October 2005

Author

Pacak, K, Eisenhofer, G, Ahlman, H, Bornstein, SR, Gimenez-Roqueplo, AP, Grossman, AB, Kimura, N, Mannelli, M, McNicol, AM, and Tischler, AS

Abstract

The First International Symposium on Pheochromocytoma, held in October 2005, included discussions about developments concerning these rare catecholamine-producing tumors. Recommendations were made during the symposium for biochemical diagnosis, localization, genetics, and treatment. Measurement of plasma or urinary fractionated metanephrines, the most accurate screening approach, was recommended as the first-line test for diagnosis; reference intervals should favor sensitivity over specificity. Localization studies should only follow reasonable clinical evidence of a tumor. Preoperative pharmacologic blockade of circulatory responses to catecholamines is mandatory. Because approximately a quarter of tumors develop secondary to germ-line mutations in any one of five genes, mutation testing should be considered; however, it is not currently cost effective to test every gene in every patient. Consideration of tumor location, presence of multiple tumors, presence of metastases, and type of catecholamine produced is useful in deciding which genes to test. Inadequate methods to distinguish malignant from benign tumors and a lack of effective treatments for malignancy are important problems requiring further resolution.

Published
2016

27. Combination Chemotherapy in Advanced Adrenocortical Carcinoma

Author

Fassnacht, M., Terzolo, M., Allolio, B., Baudin, E., Haak, H., Berruti, A., Welin, S., Schade Brittinger, C., Lacroix, A., Jarzab, B., Sorbye, H., Torpy, D. J., Stepan, V., Schteingart, D. E., Arlt, W., Kroiss, M., Leboulleux, S., Sperone, P., Sundin, A., Hermsen, I., Hahner, S., Willenberg, H. S., Tabarin, A., Quinkler, M., De La Fouchardiere, C., Schlumberger, M., Mantero, F., Weismann, D., Beuschlein, F., Gelderblom, H., Wilmink, H., Sender, M., Edgerly, M., Kenn, W., Fojo, T., Muller, H. H., Skogseid, B., Haaf, M., Johanssen, S., Koschker, A. C., Laubner, K., Sbiera, S., Schiemann, J., Wortmann, S., Haase, M., Schott, M., Möhlig, M., Zopf, K., Reisch, N., Betz, M., Reincke, M., Isermann, B., Bornstein, S., Fottner, C., Bose, A., Petersenn, S., Leitolf, H., Klose, S., Wolf, H., Chougnet, C., More, J., Nunes, M. L., Droz, J. P., Nicolli, P., Chabre, O., Clergeot, A., Schillo, F., Penfornis, A., Do Cao, C., Goldwasser, F., Rodien, P., Ferrero, A., Perotti, P., Cicala Mv, Anna P., Della Casa, S., Mannelli, M., Piccini, V., Dercksen, M. W., Romijn, J. A., Ouwerkerk, J., Devries, J. H., Eriksson, B., Janson, E. T., Granberg, D., Oberg, K., Ahlman, H., Garkavij, M., Wall, N., Falkmer, U., Hammer, G., Olney, H. J., Bourdeau, I., Bourque, L., Szpak Ulczok, S., Jarzab, M., Holte, H., Fossa, A., Ploner, F., Mansmann, U., Schmoll, H. J., Simonsson, B., Toscano, Vincenzo, Petersenn, Stephan (Beitragende*r), CCA -Cancer Center Amsterdam, Oncology, Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, and Endocrinology

Subjects
Adult, Male, adrenal tumor, medicine.medical_specialty, Medizin, Kaplan-Meier Estimate, Gastroenterology, Disease-Free Survival, Streptozocin, Young Adult, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Adrenocortical Carcinoma, Medicine, Adrenocortical carcinoma, Humans, Mitotane, Adverse effect, Etoposide, Aged, Intention-to-treat analysis, business.industry, Medicine (all), Hazard ratio, Combination chemotherapy, General Medicine, Middle Aged, medicine.disease, Adrenal Cortex Neoplasms, Surgery, Intention to Treat Analysis, Regimen, Doxorubicin, Cisplatin, Female, Quality of Life, business, medicine.drug
Abstract

A b s t r ac t Background Adrenocortical carcinoma is a rare cancer that has a poor response to cytotoxic treatment. Methods We randomly assigned 304 patients with advanced adrenocortical carcinoma to re ceive mitotane plus either a combination of etoposide (100 mg per square meter of body-surface area on days 2 to 4), doxorubicin (40 mg per square meter on day 1), and cisplatin (40 mg per square meter on days 3 and 4) (EDP) every 4 weeks or streptozocin (streptozotocin) (1 g on days 1 to 5 in cycle 1; 2 g on day 1 in subsequent cycles) every 3 weeks. Patients with disease progression received the alternative regimen as second-line therapy. The primary end point was overall survival. Results For first-line therapy, patients in the EDP–mitotane group had a significantly higher response rate than those in the streptozocin–mitotane group (23.2% vs. 9.2%, P

Published
2012

28. Advances in the diagnostic imaging of pheochromocytomas

Author

Forssell-Aronsson E, Schüler E, and Ahlman H

Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine, lcsh:R895-920
Abstract

Eva Forssell-Aronsson1, Emil Schüler1, Håkan Ahlman21Department of Radiation Physics, 2Department of Surgery, Lundberg Laboratory of Cancer Research, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, SwedenAbstract: Pheochromocytomas (PCs) and paragangliomas (PGLs) are routinely localized by computed tomography (CT), magnetic resonance imaging (MRI), and metaiodobenzylguanidine (MIBG) scintigraphy. CT can identify tumors with high sensitivity but rather low specificity. MRI has higher sensitivity and specificity than CT and is superior to detect extra-adrenal disease. Radioiodinated MIBG scintigraphy has been used for more than 30 years and is based on MIBG uptake via the norepinephrine transporter on the cell membrane. The technique is very useful for whole-body studies in case of multiple primary tumors or metastases. Tumors with sole production of dopamine usually cannot be visualized with MIBG and may require positron emission tomographic (PET) studies with 18F-labeled radiotracers. Somatostatin receptor scintigraphy (SRS) using the radiolabeled somatostatin analog octreotide (based on the expression of the somatostatin receptors 2 and 5 by the tumor) can demonstrate PGL or metastases not visualized by MIBG. In this article, we review the use of MIBG scintigraphy to diagnose PC/PGL and compare the sensitivity and specificity with that of CT and MRI. We also describe the recent SRS and PET techniques and review the latest results of clinical studies by comparing these imaging modalities. Future perspectives of functional imaging modalities for PC/PGL are finally presented.Keywords: MIBG, scintigraphy, pheochromocytoma, paraganglioma, PET

Published
2011

29. Consensus guidelines for the management of patients with liver metastases from digestive (neuro) endocrine tumors: Foregut, midgut, hindgut, and unknown primary

Author

Steinmüller, T., Kianmanesh, R., Falconi, Massimo, Scarpa, Aldo, Taal, B., Kwekkeboom, D., Lopes, J., Perren, A., Nikou, G., Yao, J., Fave, G. D., O'Toole, D., Ahlman, H., Arnold, R., Auernhammer, C., Caplin, M., Christ, E., Couvelard, A., Herder, W. D., Eriksson, B., Ferone, D., Goretzki, P., Gross, D., Hyrdel, R., Jensen, R., Kaltsas, G., Keleştimur, F., Klöppel, G., Knapp, W., Knigge, U., Komminoth, P., Körner, M., Kos Kudła, B., Krenning, E., Kulke, M., Kvols, L., Manfredi, Riccardo, Mcnicol, A., Niederle, B., Nilsson, O., Öberg, K., O'Connor, J., Pape, U., Pavel, M., Plöckinger, U., Ramage, J., Ricke, J., Rindi, G., Ruszniewski, P., Salazar, R., Scoazec, J., Garcia, M. S., Sundin, A., Vullierme, M., Wiedenmann, B., Wildi, S., Thomas, Steinmüller, Reza, Kianmanesh, Falconi, Massimo, Aldo, Scarpa, Babs, Taal, Dik J., Kwekkeboom, José M., Lope, Aurel, Perren, George, Nikou, James, Yao, Gian Franco, Delle, Dermot, O'Toole, Frascati Consensus, Conference, Radiology & Nuclear Medicine, and Cardiology

Subjects
medicine.medical_specialty, Consensus, ACTING SOMATOSTATIN ANALOG, Endocrinology, Diabetes and Metabolism, Guidelines as Topic, Biology, HEPATIC ARTERIAL CHEMOEMBOLIZATION, Metastasis, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, Endocrine Gland Neoplasms, medicine, Digestive System, Humans, Liver Neoplasms, Endocrine system, Endocrine gland neoplasm, Endocrine and Autonomic Systems, General surgery, Cancer, Hindgut, Midgut, Foregut, LASER-INDUCED THERMOTHERAPY, medicine.disease, HEPATIC ARTERIAL CHEMOEMBOLIZATION, GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS, LASER-INDUCED THERMOTHERAPY, ACTING SOMATOSTATIN ANALOG, PORTAL-VEIN EMBOLIZATION, ISLET-CELL CARCINOMA, ISLET-CELL CARCINOMA, PORTAL-VEIN EMBOLIZATION, Unknown primary, GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS
Abstract

a DRK Kliniken Westend, Berlin , Germany; b UFR Bichat-Beaujon-Louis Mourier, Service de Chirurgie Digestive, Hopital Louis Mourier, Colombes , France; c Medicine and Surgery, General Surgery Section, MED/18 – General Surgery and d Department of Pathology, University of Verona, Verona , Italy; e Netherlands Cancer Centre, Amsterdam , and f Department of Nuclear Medicine, Erasmus University Medical Center, Rotterdam , The Netherlands

Published
2008

30. Consensus guidelines for the management of patients with digestive neuroendocrine tumors - Well-differentiated jejunal-ileal tumor/carcinoma

Author

Eriksson, B., Klöppel, G., Krenning, E., Ahlman, H., Plöckinger, U., Wiedenmann, B., Arnold, R., Auernhammer, C., Körner, M., Rindi, G., Wildi, S., Caplin, M., Fave, G. D., Ferone, D., Goretzki, P., Hyrdel, R., Jensen, R., Kaltsas, G., Keleştimur, F., Kianmanesh, R., Komminoth, P., Kos Kudła, B., Kvols, L., Kwekkeboom, D., Lopes, J., Manfredi, Riccardo, Mcnicol, A., Niederle, B., Nilsson, O., Nikou, G., Öberg, K., O'Connor, J., O'Toole, D., Pavel, M., Perren, A., Ramage, J., Ricke, J., Ruszniewski, P., Scarpa, Aldo, Scoazec, J., Garcia, M. S., Steinmüller, T., Taal, B., Vullierme, M., Yao, J., and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, Pathology, Consensus, MIDGUT CARCINOID-TUMORS, ENDOCRINE GASTROENTEROPANCREATIC TUMORS, RECEPTOR-MEDIATED RADIOTHERAPY, RADIOLABELED SOMATOSTATIN ANALOG, RECOMBINANT INTERFERON-ALPHA, RADIONUCLIDE THERAPY, MIDGUT CARCINOID-TUMORS, Endocrinology, Diabetes and Metabolism, RADIONUCLIDE THERAPY, Neuroendocrine tumors, digestive system, RECOMBINANT INTERFERON-ALPHA, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, Carcinoma, Humans, Medicine, ENDOCRINE GASTROENTEROPANCREATIC TUMORS, Gastrointestinal Neuroendocrine Tumor, RADIOLABELED SOMATOSTATIN ANALOG, Jejunal Neoplasms, Endocrine and Autonomic Systems, business.industry, digestive, oral, and skin physiology, Metastatic carcinoid tumor, Cancer, medicine.disease, Carcinoma, Neuroendocrine, Well differentiated, Ileal Neoplasms, Practice Guidelines as Topic, Radionuclide therapy, Neuroendocrine therapy, business, RECEPTOR-MEDIATED RADIOTHERAPY
Abstract

Consensus guidelines for the management of patients with digestive neuroendocrine tumors : well-differentiated jejunal-ileal tumor/carcinoma

Published
2008

31. Poorly differentiated carcinomas of the foregut (gastric, duodenal and pancreatic)

Author

Nilsson, O., Cutsem, E. V., Fave, G. D., Yao, J., Pavel, M., Mcnicol, A., Garcia, M. S., Knapp, W., Keleştimur, F., Sauvanet, A., Pauwels, S., Kwekkeboom, D., Caplin, M., Ahlman, H., Arnold, R., Bechstein, W., Cadiot, G., Christ, E., Chung, D., Couvelard, A., Herder, W. D., Eriksson, B., Falchetti, A., Falconi, Massimo, Ferone, D., Goretzki, P., Gross, D., Hochhauser, D., Hyrdel, R., Jensen, R., Kaltsas, G., Kianmanesh, R., Knigge, U., Komminoth, P., Körner, M., Kos Kudła, B., Kvols, L., Lewington, V., Lopes, J., Manfredi, Riccardo, Mitry, E., Niederle, B., Nikou, G., Öberg, K., O'Connor, J., O'Toole, D., Pape, U., Perren, A., Plöckinger, U., Ramage, J., Ricke, J., Rindi, G., Ruszniewski, P., Salazar, R., Scarpa, Aldo, Scoazec, J., Steinmüller, T., Sundin, A., Taal, B., Vullierme, M., Wiedenmann, B., Wildi, S., Zgliczynski, S., Radiology & Nuclear Medicine, O., Nilsson, E. V., Cutsem, G. D., Fave, J., Yao, M., Pavel, A., Mcnicol, M. S., Garcia, W., Knapp, F., Keleştimur, A., Sauvanet, S., Pauwel, D., Kwekkeboom, M., Caplin, and Falconi, M

Subjects
SMALL-CELL-CARCINOMA, NEUROENDOCRINE CARCINOMAS, TUMORS, CHEMOTHERAPY, STOMACH, MANAGEMENT, CISPLATIN, ETOPOSIDE, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Biology, Cellular and Molecular Neuroscience, CISPLATIN, Endocrinology, Duodenal Neoplasms, Stomach Neoplasms, Internal medicine, STOMACH, SMALL-CELL-CARCINOMA, medicine, MANAGEMENT, Humans, ddc:610, Royal infirmary, Endocrine and Autonomic Systems, Poorly differentiated, General surgery, GASTRIC/DUODENAL, Carcinoma, CHEMOTHERAPY, TUMORS, Neuroendocrine Carcinomas, Pancreatic Neoplasms, ETOPOSIDE, NEUROENDOCRINE CARCINOMAS
Abstract

a Department of Pathology, Gothenburg University, Gothenburg , Sweden; b Department of Gastroenterology, Gasthuisberg University, Leuven , Belgium; c Department of Gastroenterology, Ospedale S. Andrea, Rome , Italy; d Department of Oncology, University of Texas, Houston, Tex. , USA; e Department of Endocrinology, Erlangen University, Erlangen , Germany; f Department of Oncology and Pathology, Royal Infirmary Hospital, Glasgow , UK; g Department of Oncology, Virgen de la Victoria Hospital, Malaga , Spain; h Department of Nuclear Medicine, Medizinische Hochschule Hannover, Hannover , Germany; i Department of Endocrinology, Erciyes University, Kayseri , Turkey; j Department of Surgery, Beaujon Hospital, Clichy , France; k Department of Nuclear Medicine, Catholique de Louvain University, Brussels , Belgium; l Department of Nuclear Medicine, Erasmus MC University, Rotterdam , The Netherlands; m Department of Gastroenterology, Royal Free Hospital, London , UK

Published
2006

32. Histamine metabolism of gastric carcinoids in Mastomys natalensis

Author

Kölby, L., Wängberg, B., Ahlman, H., Modlin, I. M., and Nilsson, O.

Subjects
endocrine system, Enterochromaffin-like Cells, Carcinoid Tumor, Histidine Decarboxylase, Triazoles, Muridae, Disease Models, Animal, Histamine H2 Antagonists, Gastric Mucosa, Stomach Neoplasms, Gastrins, Animals, Research Article, Histamine
Abstract

Pharmacological inhibition of gastric acid secretion and subsequent hypergastrinemia in Mastomys natalensis is an experimental model well suited for the study of gastric carcinoid formation. The genetic susceptibility of Mastomys to develop such tumors is a feature reminiscent of the situation in patients with the MEN-1 Zollinger Ellison syndrome, in whom tumor-induced hypergastrinemia, promotes the development of gastric carcinoids. Chronic hypergastrinemia, induced by the irreversible H2-receptor antagonist loxtidine will cause carcinoid formation in Mastomys already after four to six months. As in humans, gastric carcinoids in Mastomys are mainly composed of enterochromaffinlike (ECL) cells and have low malignant potential. Administration of exogenous gastrin to normal young animals increases the expression of histidine decarboxylase (HDC) mRNA in the oxyntic mucosa within 30 minutes. Endogenous hypergastrinemia, induced by short-time loxtidine treatment (three to 29 days) enhances the expression of HDC mRNA, histamine contents and ECL cell numbers in the oxyntic mucosa. Long-term loxtidine treatment (seven to 21 months) results in sustained hypergastrinemia and tumor formation. Tumor-bearing animals exhibited an increase in HDC mRNA and histamine content in the oxyntic mucosa as well as increased urinary excretion of the main histamine metabolite, tele-methylimidazole acetic acid (MeImAA). Subsequent to cessation of loxtidine treatment for two weeks, all parameters of histamine metabolism were normalized in tumor-bearing animals. These results indicate that gastric carcinoids developing during hypergastrinemia are well-differentiated neoplasms whose histamine synthesis and metabolism is regulated by plasma gastrin. Images Figure 1 Figure 2

Published
1998

43. Abstracts

Author

Abdullah, Lubna H., Buchanan, K. D., Akopyan, T. N., Arzumanyan, A. M., Arutunyan, A. A., Berger, H., Oehme, P., Atkinson, M. E., Chaggar, J. S., Bailey, S. J., Featherstone, R. L., Jordan, C. C., Morton, I. K. M., Balfe, A., Skrabanek, P., Powell, D., Barja, F., Mathison, R., Huggel, H., Bittiger, H., Heid, J., Björkroth, Ulla, Rosell, Sune, Boyd, N. D., Anthony, M. P., Leeman, S. E., Briggs, I., Growcott, J. W., Jamieson, A., Tarpey, Ann V., Brodin, E., Meyerson, B. A., Brown, J. R., Hayes, A. G., Meecham, K. G., Tyers, M. B., Burcher, E., Bynke, G., Håkanson, R., Hörig, J., Cann, John R., Rahim, Iffat, Vatter, Albert, Stewart, John M., Cascieri, Margaret A., Liang, Tehming, Cheeseman, H. J., Pinnock, R. O., Henderson, G., Constantinidis, J., Bouras, C., Taban, C. H., Guntern, R., Couture, R., Cuello, A. C., Dalsgaard, C. -J., Jonsson, C. -E., Arvidsson, J., Risling, M., Hökfelt, T., Schultzberg, M., Vincent, S. R., Elfvin, L. -G., de Beaurepaire, R., Iversen, S. D., Delbro, D., Lisander, B., Fändriks, L., Andersson, S. A., Del Fiacco, M., Dessi, M. L., Levarvti, M. C., Del Rio, J., Naranjo, J. R., Domschke, S., Bloom, S. R., Adrian, T. E., Lux, G., Bryant, M. G., McGregor, G. P., Domschke, W., Donnerer, J., Barthó, L., Holzer, P., Lembeck, F., Skofitsch, G., Elliott, P. J., Bannon, M. J., Alpert, J. E., Ferri, G. -L, McGregor, G., Vezzadini, P., Labo, G., Polak, J. M., Fontaine-Perus, J. C., Chanconie, M., Foreman, J. C., Piotrowski, W., Fox, J. E. T., Daniel, E. E., Jury, J., Domoto, T., Berezin, I., Gaudino, G., Mondardini, L., Fasolo, A., Gazelius, B., Kahan, T., Panopoulos, P., Olgart, L., Gintzler, Alan R., Jaffe, Bernard M., Baron, Sheri A., GrÖnstad, K. O., Ahlman, H., Zinner, M. J., Jaffe, B. M., Yeo, C., Gu, J., Huang, W. M., lslam, K. N., Terenghi, G., Morrison, J., Güllner, H. -G., Haeusler, Guenther, Handelmann, Gail E., Selsky, Joyce H., Helme, R. D., White, D. M., Höfler, H., Heitzt, Ph. U., Auböck, L., Petsche, Ulrike, Lippe, Irmgard, Hylden, Janice L. K., Wilcox, George L., Inoue, Atsuko, Nakata, Yoshihiro, Segawa, Tomio, Jakubowska-Naziemblo, B., Potargowicz, E., Traczyk, W. Z., Cannon, D., Rohde, W., JancsÓ, G., Király, E., Karcsú, S., Szebeni, A., Bácsy, E., Jones, R. S. G., Olpe, H. -R., Wrightt, D. M., Jurna, I., Kerdelhué, B., Lenoir, V., Pasqualini, C., El Abed, A., Morel, G., Dubois, P., Hublot, P., Tartar, A., Klingmúller, D., Waltz, C., Kramer, H. J., Koop, H., Luster, W., Gropp, C., Havemenn, K., Arnold, R., Krause, James E., McKelvy, Jeffrey F., Krivoy, W., Couch, J., Strand, F., Leander, S., Folkers, K., Lee, C. M., Snyder, S. H., Lindberg, P., Dahlström, A., Lundberg, J. M., Lindefors, N., Ungerstedt, U., Liu-Chen, L. -Y., Liszczak, T., Mayberg, M. R., Moskowitz, M. A., Lundberg, Jan M., Saria, Alois, Brodin, Ernst, Martling, Claes-Roland, Hökfelt, Tomas, Lundblad, Lars, Änggård, Anders, McGeeney, K. F., O'Donnell, M. D., Blank, M. A., Manolas, K., Linger, W. G., Allen, J. M., Maggio, J. E., Sandberg, B. E. B., Bradley, C. V., Iversen, L. L., Santikarn, S., Williams, D. H., Hunter, J. C., Hanley, M. R., Magnusson, I., Thulin, L., Mandahl, Agneta, Bill, Anders, Manning, Maurice, Martensson, H., Akande, B., Stofer, P., Chappuis, G., Immer, H., Groog, P., Matthews, Margaret R., Connaughton, M., Moratalla, R., Nobin, Anders, Emson, Piers, Sundler, Frank, O'Donohue, T. L., Shults, C. W., Quirion, R., Moody, T. W., Chase, T. N., Otsuka, M., Konishi, S., Yanagisawa, M., Akagi, H., Otten, U., Rüegg, U. T., Pawlik, W., Konturek, S. J., Kania, J., Gustaw, P., Cosgrove, Patricia G., Pazoles, Christopher J., Priestley, J. V., Jensen, R. T., Pert, C. B., Regoli, D., Mizrahi, J., D'Orléans-Juste, P., Caranikas, S., Escher, E., Folkers, Karl, Rüegg, Urs T., Bishai, W. R., Saria, A., Rama Sastry, B. V., Jaiswal, Neelam, Tayeb, Osama S., Schultheiss, Hartmut, Hörig, Joachim, Scott, T. M., Shanahan, F., Befus, A. D., Fox, J., Denburg, J. A., Bienenstock, J., Sheppard, M. N., Kurian, S. S., Siegel, R. A., Weidenfeld, J., Globus, M., Melamed, E., Sjödin, L., Srivastava, G., Hall, Michael E., Suhar, A., Turk, V., Marks, N., Szkudlarek, U., Tarkkanen, A., Tervo, T., Tervo, K., Eränkö, L., Eränkö, O., Huang, W. -M., Morrison, J. F. B., Unger, W. G., Tessler, A., Himes, B. T., Murray, M., Goldberger, M. E., Torrens, Y., Beaujouan, J. C., Viger, A., Glowinski, J., Casanueva, F. F., Knuth, E., Havlicek, V., Friesen, H. G., Triepel, J., Weindl, A., Reinecke, M., Mader, J., Forssmann, W. G., Unger, Thomas, Becker, Hans, König, Manfred, Ganten, Detlev, Lang, Rudolf E., Vacca, L. L., Naftchi, N. E., Guan, X. -M., Ai, M. -K., Vijayan, E., Wang, Y. M., Mashford, M. L., Watson, Stephen P., Sandberg, Bengt E. B., Iversen, Leslie L., Weihe, E., Hartschuh, W., Kuchling, G., Winter, E. A., Keen, P., Yeo, C. J., Ylikoski, Jukka, Tervo, Timo, Tervo, Kaarina, Eränko, Liisa, and Cuello, Claudio

Published
1983
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46. Praomys (Mastomys) natalensis: a model for gastric carcinoid formation

Author

Nilsson, O., Wängberg, B., Johansson, L., Modlin, I. M., and Ahlman, H.

Subjects
Muridae, endocrine system, Disease Models, Animal, Cell Transformation, Neoplastic, Stomach Neoplasms, Animals, Humans, Carcinoid Tumor, digestive system diseases, Research Article
Abstract

The gastric carcinoid tumors of Praomys (Mastomys) natalensis have been reviewed with respect to histogenesis, development, biochemistry, and morphological properties. Multicentric gastric carcinoids frequently develop in the oxyntic mucosa of aging Mastomys. The development of these tumors can be significantly enhanced by drug-induced hypergastrinemia, e.g., histamine2-receptor blockade. Spontaneous and drug-induced gastric carcinoids are endocrine in nature, as evidenced by their argyrophilic staining properties and chromogranin A content. They are also rich in histidine decarboxylase activity and produce large amounts of histamine, although other hormones, such as peptide YY and enteroglucagon, have also been demonstrated in these tumors. Ultrastructurally, gastric carcinoids are composed of tumor cells with typical secretory granules resembling those of enterochromaffin-like (ECL) cells. A close examination of the gastric carcinoids in Mastomys reveals striking similarities with gastric carcinoids developing in humans suffering from chronic atrophic gastritis type A or from the Zollinger-Ellison syndrome in combination with multiple endocrine neoplasia type 1 (MEN-1). Both these conditions are associated with hypergastrinemia and a higher risk for developing multi-centric gastric carcinoids of ECL-cell origin. The Mastomys tumor model therefore appears to be a significant experimental model in which induction and formation of gastric carcinoid tumors can be studied. Images FIG. 1 FIG. 2 FIG. 3

Published
1992

47. Well-differentiated pancreatic tumor/carcinoma: Insulinoma

Author

Herder, W. D., Niederle, B., Scoazec, J., Pauwels, S., Klöppel, G., Falconi, Massimo, Kwekkeboom, D., Öberg, K., Eriksson, B., Wiedenmann, B., Rindi, G., O'Toole, D., Ferone, D., Ahlman, H., Arnold, R., Bechstein, W., Cadiot, G., Caplin, M., Christ, E., Chung, D., Couvelard, A., Fave, G. D., Falchetti, A., Goretzki, P., Gross, D., Hochhauser, D., Hyrdel, R., Jensen, R., Kaltsas, G., Keleştimur, F., Kianmanesh, R., Knapp, W., Knigge, U., Komminoth, P., Körner, M., Kos Kudła, B., Kvols, L., Lewington, V., Lopes, J., Manfredi, Riccardo, Mcnicol, A., Mitry, E., Nikou, G., Nilsson, O., O'Connor, J., Pape, U., Pavel, M., Perren, A., Plöckinger, U., Ramage, J., Ricke, J., Ruszniewski, P., Salazar, R., Sauvanet, A., Scarpa, Aldo, Garcia, M. S., Steinmüller, T., Sundin, A., Taal, B., Cutsem, E. V., Vullierme, M., Wildi, S., Yao, J., Zgliczyñski, S., W. W., de Herder, B., Niederle, J., Scoazec, S., Pauwel, G., Kloppel, Falconi, Massimo, D. J., Kwekkeboom, K., Oberg, B., Eriksson, B., Wiedenmann, G., Rindi, D., O'Toole, D., Ferone, F. C., Conference, E. N., Tumor Society, Internal Medicine, and Gastroenterology & Hepatology

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Intraoperative ultrasound, Carcinoma pancreas, Cellular and Molecular Neuroscience, Endocrinology, OCTREOTIDE, Internal medicine, medicine, ENDOSCOPIC ULTRASOUND, Humans, Carcinoma, Insulinoma, Pancreatic Neoplasms, Pancreas Carcinoma, Somatostatin receptor scintigraphy, SLET-CELL TUMORS, Endocrine and Autonomic Systems, business.industry, General surgery, HYPERINSULINEMIC HYPOGLYCEMIA, LOCALIZATION, University hospital, Well differentiated, SLET-CELL TUMORS, SOMATOSTATIN RECEPTOR SCINTIGRAPHY, NEUROENDOCRINE TUMORS, HYPERINSULINEMIC HYPOGLYCEMIA, INTRAOPERATIVE ULTRASOUND, ENDOSCOPIC ULTRASOUND, ENDOCRINE TUMORS, LOCALIZATION, OCTREOTIDE, MRI, ENDOCRINE TUMORS, INTRAOPERATIVE ULTRASOUND, business, SOMATOSTATIN RECEPTOR SCINTIGRAPHY, NEUROENDOCRINE TUMORS, MRI
Abstract

a Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands; b Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna , Austria; c Hospices Civils de Lyon, Hopital Edouard-Herriot Service Central d‘Anatomie et Cytologie Pathologiques, Lyon , France; d Centre de Medecine Nucleaire, Universite Catholique de Louvain, Brussels , Belgium; e Department of Pathology, University of Kiel, Kiel , Germany; f B Unit of Surgery, Department of Surgery, University of Verona, Verona , Italy; g Department of Nuclear Medicine, Erasmus MC, Rotterdam , The Netherlands; h Department of Endocrine Oncology, University Hospital, Uppsala , Sweden; i Department of Internal Medicine, Division of Hepatology and Gastroenterology, Interdisciplinary Center of Metabolism and Endocrinology, Charite, Campus Virchow Hospital, University for Medicine Berlin, Berlin , Germany; j Service de Gastroenterologie-Pancreatologie, Pole des Maladies de l‘Appareil Digestif, Hopital Beaujon, Clichy , France; k Department of Pathology and Laboratory Medicine, Universita degli Studi, Parma, Italy; l Department of Endocrinology, Genoa University, Genoa , Italy

Published
2006

48. Well-differenitated duodenal tumor/carcinoma(excluding gastrinomas)

Author

Jensen, R., Rindi, G., Arnold, R., Lopes, J., Brandi, M., Bechstein, W., Christ, E., Taal, B., Knigge, U., Ahlman, H., Kwekkeboom, D., O'Toole, D., Cadiot, G., Caplin, M., Chung, D., Couvelard, A., Herder, W. D., Fave, G. D., Eriksson, B., Falchetti, A., Falconi, Massimo, Ferone, D., Goretzki, P., Gross, D., Hochhauser, D., Hyrdel, R., Kaltsas, G., Keleştimur, F., Kianmanesh, R., Knapp, W., Komminoth, P., Körner, M., Kos Kudła, B., Kvols, L., Lewington, V., Manfredi, Riccardo, Mcnicol, A., Mitry, E., Niederle, B., Nikou, G., Nilsson, O., Öberg, K., O'Connor, J., Pauwels, S., Pape, U., Pavel, M., Perren, A., Plöckinger, U., Ramage, J., Ricke, J., Ruszniewski, P., Salazar, R., Sauvanet, A., Scarpa, Aldo, Scoazec, J., Garcia, M. S., Steinmüller, T., Sundin, A., Cutsem, E. V., Vullierme, M., Wiedenmann, B., Wildi, S., Yao, J., Zgliczynski, S., Radiology & Nuclear Medicine, R., Jensen, G., Rindi, R., Arnold, J., Lope, M., Brandi, W., Bechstein, E., Christ, B., Taal, U., Knigge, H., Ahlman, D., Kwekkeboom, D., O'Toole, G., Cadiot, M., Caplin, D., Chung, A., Couvelard, W. D., Herder, G. D., Fave, B., Eriksson, A., Falchetti, Falconi, Massimo, D., Ferone, P., Goretzki, D., Gro, D., Hochhauser, R., Hyrdel, G., Kaltsa, F., Keleştimur, R., Kianmanesh, W., Knapp, P., Komminoth, M., Körner, B., Kos Kudła, L., Kvol, V., Lewington, R., Manfredi, A., Mcnicol, E., Mitry, B., Niederle, G., Nikou, O., Nilsson, K., Öberg, J., O'Connor, S., Pauwel, U., Pape, M., Pavel, A., Perren, U., Plöckinger, J., Ramage, J., Ricke, P., Ruszniewski, R., Salazar, A., Sauvanet, A., Scarpa, J., Scoazec, M. S., Garcia, T., Steinmüller, A., Sundin, E. V., Cutsem, M., Vullierme, B., Wiedenmann, S., Wildi, J., Yao, and S., Zgliczynski

Subjects
ENDOCRINE GASTROENTEROPANCREATIC TUMORS, medicine.medical_specialty, Somatostatin receptor scintigraphy, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, General surgery, Carcinoma, ZOLLINGER-ELLISON-SYNDROME, Well differentiated, Cellular and Molecular Neuroscience, Endocrinology, Duodenal Neoplasms, Internal medicine, Duodenal Tumor, Cancer centre, medicine, AMPULLARY CARCINOID-TUMORS, Humans, ZOLLINGER-ELLISON-SYNDROME, SOMATOSTATIN RECEPTOR SCINTIGRAPHY, ENDOCRINE GASTROENTEROPANCREATIC TUMORS, AMPULLARY CARCINOID-TUMORS, business, SOMATOSTATIN RECEPTOR SCINTIGRAPHY
Abstract

a Digestive Diseases Branch, NIDDK, NIH, Bethesda, Md. , USA; b Dipartimento di Patologia e Medicina di Laboratorio, Universita di Parma, Parma , Italy; c Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps University, Marburg , Germany; d Department of Pathology, IPATIMUP Hospital, Porto , Portugal; e Dipartimento di Fisiopatologia Clinica, Universita di Firenze, Firenze , Italy; f Department of Surgery, Johann-Wolfgang-Goethe-Universitat, Frankfurt , Germany; g E. Christ, Department of Endocrinology, Inselspital, Bern , Switzerland; h Department of Oncology, Netherlands Cancer Centre, Amsterdam , The Netherlands; i Department of Surgery, Rigshospitalet Blegdamsvej Hospital, Copenhagen , Denmark; j Department of Surgery, Gothenburg University, Gothenburg , Sweden; k Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam , The Netherlands; l Service de Gastroenterologie-Pancreatologie, Pole des Maladies de l’Appareil Digestif, Hopital Beaujon, Clichy , France

Published
2006

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