1. Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
- Author
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Bastard, Paul, Gervais, Adrian, Taniguchi, Maki, Saare, Liisa, Särekannu, Karita, Le Voyer, Tom, Philippot, Quentin, Rosain, Jérémie, Bizien, Lucy, Asano, Takaki, Garcia-Prat, Marina, Parra-Martínez, Alba, Migaud, Mélanie, Tsumura, Miyuki, Conti, Francesca, Belot, Alexandre, Rivière, Jacques G., Morio, Tomohiro, Tanaka, Junko, Javouhey, Etienne, Haerynck, Filomeen, Duvlis, Sotirija, Ozcelik, Tayfun, Keles, Sevgi, Tandjaoui-Lambiotte, Yacine, Escoda, Simon, Husain, Maya, Pan-Hammarström, Qiang, Hammarström, Lennart, Ahlijah, Gloria, Abi Haidar, Anthony, Soudee, Camille, Arseguel, Vincent, Abolhassani, Hassan, Sahanic, Sabina, Tancevski, Ivan, Nukui, Yoko, Hayakawa, Seiichi, Chrousos, George P., Michos, Athanasios, Tatsi, Elizabeth-Barbara, Filippatos, Filippos, Rodriguez-Palmero, Agusti, Troya, Jesus, Tipu, Imran, Meyts, Isabelle, Roussel, Lucie, Ostrowski, Sisse Rye, Schidlowski, Laire, Prando, Carolina, Condino-Neto, Antonio, Cheikh, Nathalie, Bousfiha, Ahmed A., El Bakkouri, Jalila, Peterson, Pärt, Pujol, Aurora, Lévy, Romain, Quartier, Pierre, Vinh, Donald C., Boisson, Bertrand, Béziat, Vivien, Zhang, Shen-Ying, Borghesi, Alessandro, Pession, Andrea, Andreakos, Evangelos, Marr, Nico, Mentis, Alexios-Fotios A., Mogensen, Trine H., Rodríguez-Gallego, Carlos, Soler-Palacin, Pere, Colobran, Roger, Tillmann, Vallo, Neven, Bénédicte, Trouillet-Assant, Sophie, Brodin, Petter, Abel, Laurent, Jouanguy, Emmanuelle, Zhang, Qian, Martinón-Torres, Federico, Salas, Antonio, Gómez-Carballa, Alberto, Gonzalez-Granado, Luis I., Kisand, Kai, Okada, Satoshi, Puel, Anne, Cobat, Aurélie, and Casanova, Jean-Laurent
- Abstract
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2.
- Published
- 2024
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