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4 results on '"Ahad Shafiei"'

1. Effect of Eight Weeks of High Intensity Interval Training on Tissue Changes and Gene Expression of APP and Tau Indices in the Hippocampus of Rats Addicted to Methamphetamine

Author

Mina Bahrami, Amir Hossein Haghighi, Majid Asadi-Shekaari, Hadi Shahrabadi, and Ahad Shafiei

Subjects
hiit, methamphetamine, app, tau and neurodegeneration., Medicine (General), R5-920
Abstract

Introduction: The use of methamphetamine (METH) can cause neurotoxicity. The purpose of this research was to investigate the effect of high intensity interval training on tissue changes and gene expression of neurodegeneration indicators in the hippocampal tissue of methamphetamine-dependent rats. Methods: In this experimental research, 32 male rats were divided into four equal groups of saline, primary methamphetamine (METH-1), methamphetamine+training (METH+HIT) and secondary methamphetamine (METH-2). METH was injected at the dose of 5 mg/kg body weight for 21 days. The exercise program (5 sessions per week) included interval training (4 sets of 2 minutes with high intensity and 2 to 4 minutes of active rest between sets) on a treadmill. At the end of the injection and training period, the hippocampus tissue of the rats was extracted to evaluate the pathological changes and gene expression of related indicators. Data were analyzed using one-way ANOVA test at the significance level of (P≥0.05) by GraphPad software. Results: The results of gene expression in the hippocampal tissue showed that along with METH injection, the expression of α-syn, GSK-3β, CDK5, APP, Tau and p-Tau indicators increased significantly; nevertheless the exercises (HIT) decreased the expression of the genes of the current research. Pathological studies showed that METH injection caused a significant increase in the destruction of neurons in the CA1 region of the hippocampus, and performing intense intermittent exercise had significantly reduced the destruction of neurons. Conclusion: Methamphetamine has caused intoxication and neurodegeneration, and HIT training has been able to improve these conditions to some extent. More research is needed in this field to reach general conclusions.

Published
2024

2. Effects of Moderate-Intensity Interval Training on Gene Expression and Antioxidant Status in the Hippocampus of Methamphetamine-Dependent Rats

Author

Ahad Shafiei, Amir Hossein Haghighi, Roya Askari, Alireza Keyhani, Mahla Sadat Nabavizadeh, and Majid Asadi-Shekaari

Subjects
Male, Memory Disorders, General Neuroscience, alpha-Synuclein, Animals, Gene Expression, Cyclin-Dependent Kinase 5, Rats, Wistar, Toxicology, Hippocampus, Antioxidants, Methamphetamine, Rats
Abstract

Methamphetamine (METH) can cause neurotoxicity and increase the risk of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. This study aimed to investigate the effect of moderate-intensity interval training (MIIT) on gene expression and antioxidant status of the hippocampus of METH-dependent rats. Thirty-two male Wistar rats were randomly divided into four equal groups (n = 8): saline, METH, MIIT, and METH + MIIT. METH was injected intraperitoneally at 5 mg/kg for 21 days. The MIIT(interval running) was performed on the treadmill 5 days a week for 8 weeks. Morris water maze test was performed to measure learning and memory. Then, the hippocampal tissue was extracted to evaluate changes in gene expression and biochemical enzymes. The data were analyzed using one-way and two-way ANOVA methods at p 0.05. The results showed that METH injection significantly reduced spatial memory and antioxidant enzymes and increased the expression of α-synuclein (α-syn), cyclin-dependent kinase 5 (CDK5), tau, and phosphorylated tau (p-tau) genes compared to the saline group. MIIT significantly increased spatial memory and antioxidant enzymes. However, it reduced α-syn, CDK5, tau, and p-tau expression. Thus, this study depicted that methamphetamine-dependent rats with memory deficits have lower antioxidant enzyme levels and higher expression of α-syn, CDK5, tau, and p-tau genes, and that an 8-week MIIT may have beneficial effects on the memory impairments as well as antioxidant status and gene expression in male rats.

Published
2022

3. Moderate-intensity interval training (MIT) can protect rats against Methamphetamine –induced injuries

Author

Alireza Keyhani, Mahla sadat Nabavi Zadeh, Roya Askari, Majid Asadi-Shekaari, Ahad Shafiei Bafti, and Amir Hossein Haghighi

Subjects
business.industry, Anesthesia, Medicine, Methamphetamine, business, Interval training, medicine.drug, Intensity (physics)
Abstract

Methamphetamine (METH) can cause neurotoxicity and increase the risk of neurodegenerative disorders such as Alzheimer disease and Parkinson disease. This study aimed to investigate the effect of moderate-intensity interval training (MIT) on gene expression and antioxidant status of the hippocampus of METH-dependent rats. Twenty-eight male Wistar rats were randomly divided into four equal groups (n=7): saline, METH, MIT, and METH+MIT. METH was injected intraperitoneally at 5 mg/kg for 21 days. The MIT (intermittent running) was performed on the treadmill 5 days a week for 8 weeks. Morris Water Maze test was performed to measure learning and memory. Then, the hippocampal tissue was extracted to evaluate changes in gene expression and biochemical enzymes. The data were analyzed using one-way and two-way ANOVA methods at P

Published
2021

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