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Your search keyword '"Aguirre-Zamorano, M.A."' showing total 4 results
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4 results on '"Aguirre-Zamorano, M.A."'

1. The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype

Author

Rueda, B., Broen, J., Torres, O., Simeon, C., Ortego-Centeno, N., Schrijvenaars, M.M.V.A.P., Vonk, M.C., Fonollosa, V., van den Hoogen, F.H.J., Coenen, M.J.H., Sanchez-Roman, J., Aguirre-Zamorano, M.A., R., Garcia-Portales, Pros, A., Camps, M.T., Gonzalez-Gay, M.A., Martin, J., and Radstake, T.R.D.J.

Subjects
Scleroderma (Disease) -- Genetic aspects, Scleroderma (Disease) -- Risk factors, Scleroderma (Disease) -- Research, Systemic scleroderma -- Genetic aspects, Systemic scleroderma -- Risk factors, Systemic scleroderma -- Research, Interleukins -- Genetic aspects, Interleukins -- Research, Health
Published
2009

2. A large multicentre analysis of CTGF - 945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype

Author

Rueda, B., Simeon, C., Hesselstrand, R., Herrick, A., Worthington, J., Ortego-Centeno, N., Riemekasten, G., Fonollosa, V., Vonk, M.C., van den Hoogen, F.H.J., Sanchez-Roman, J., Aguirre-Zamorano, M.A., Garcia-Portales, R., Pros, A., Camps, M.T., Gonzalez-Gay, M.A., Gonzalez-Escribano, M.F., Coenen, M.J., Lambert, N., Nelson, J.L., Radstake, T.R.D.J., and Martin, J.

Subjects
Scleroderma (Disease) -- Genetic aspects, Scleroderma (Disease) -- Risk factors, Scleroderma (Disease) -- Research, Systemic scleroderma -- Genetic aspects, Systemic scleroderma -- Risk factors, Systemic scleroderma -- Research, Growth factors -- Genetic aspects, Growth factors -- Research, Genetic polymorphisms -- Research, Health
Published
2009

3. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype.

Author

Rueda, B., Broen, J., Simeon, C., Hesselstrand, R., Diaz, B., Suarez, H., Ortego-Centeno, N., Riemekasten, G., Fonollosa, V., Vonk, M.C., Hoogen, F.H.J. van den, Sanchez-Roman, J., Aguirre-Zamorano, M.A., Garcia-Portales, R., Pros, A., Camps, M.T., Gonzalez-Gay, M.A., Coenen, M.J.H., Airo, P., Beretta, L., Scorza, R., Laar, J. van, Gonzalez-Escribano, M.F., Nelson, J.L., Radstake, T.R.D.J., Martin, J., Rueda, B., Broen, J., Simeon, C., Hesselstrand, R., Diaz, B., Suarez, H., Ortego-Centeno, N., Riemekasten, G., Fonollosa, V., Vonk, M.C., Hoogen, F.H.J. van den, Sanchez-Roman, J., Aguirre-Zamorano, M.A., Garcia-Portales, R., Pros, A., Camps, M.T., Gonzalez-Gay, M.A., Coenen, M.J.H., Airo, P., Beretta, L., Scorza, R., Laar, J. van, Gonzalez-Escribano, M.F., Nelson, J.L., Radstake, T.R.D.J., and Martin, J.

Abstract

Contains fulltext : 81363.pdf (publisher's version ) (Closed access), The aim of this study was to investigate the possible role of STAT4 gene in the genetic predisposition to systemic sclerosis (SSc) susceptibility or clinical phenotype. A total of 1317 SSc patients [896 with limited cutaneous SSc (lcSSc) and 421 with diffuse cutaneous SSc (dcSSc)] and 3113 healthy controls, from an initial case-control set of Spanish Caucasian ancestry and five independent cohorts of European ancestry (The Netherlands, Germany, Sweden, Italy and USA), were included in the study. The rs7574865 polymorphism was selected as STAT4 genetic marker. We observed that the rs7574865 T allele was significantly associated with susceptibility to lcSSc in the Spanish population [P = 1.9 x 10(-5) odds ratio (OR) 1.61 95% confidence intervals (CI) 1.29-1.99], but not with dcSSc (P = 0.41 OR 0.84 95% CI 0.59-1.21). Additionally, a dosage effect was observed showing individuals with rs7574865 TT genotype higher risk for lcSSc (OR 3.34, P = 1.02 x 10(-7) 95% CI 2.11-5.31). The association of the rs7574865 T allele with lcSSc was confirmed in all the replication cohorts with different effect sizes (OR ranging between 1.15 and 1.86), as well as the lack of association of STAT4 with dcSSc. A meta-analysis to test the overall effect of the rs7574865 polymorphism showed a strong risk effect of the T allele for lcSSc susceptibility (pooled OR 1.54 95% CI 1.36-1.74; P < 0.0001). Our data show a strong and reproducible association of the STAT4 gene with the genetic predisposition to lcSSc suggesting that this gene seems to be one of the genetic markers influencing SSc phenotype.

Published
2009

4. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype

Author

Rueda, B., primary, Broen, J., additional, Simeon, C., additional, Hesselstrand, R., additional, Diaz, B., additional, Suarez, H., additional, Ortego-Centeno, N., additional, Riemekasten, G., additional, Fonollosa, V., additional, Vonk, M.C., additional, van den Hoogen, F.H.J., additional, Sanchez-Roman, J., additional, Aguirre-Zamorano, M.A., additional, Garcia-Portales, R., additional, Pros, A., additional, Camps, M.T., additional, Gonzalez-Gay, M.A., additional, Coenen, M.J.H., additional, Airo, P., additional, Beretta, L., additional, Scorza, R., additional, van Laar, J., additional, Gonzalez-Escribano, M.F., additional, Nelson, J.L., additional, Radstake, T.R.D.J., additional, and Martin, J., additional

Published
2009
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