22 results on '"Aguilar-Villalobos M"'
Search Results
2. Characterizing the Spatiotemporal Variability of PM2.5in Cusco, Peru Using Kriging with External Drift.
- Author
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Pearce, JL, primary, Rathbun, SL, additional, Aguilar-Villalobos, M, additional, and Naeher, LP, additional
- Published
- 2009
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3. Personal Exposure of Children to CO and VOCs in Trujillo, Peru
- Author
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Aguilar-Villalobos, M, primary and Naeher, L, additional
- Published
- 2006
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4. Use of GIS to Characterize Pedestrian Exposure to Street Level Air Pollution–Cusco, Peru
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Pearce, J, primary, Naeher, L, additional, Aguilar-Villalobos, M, additional, and Ryan, B, additional
- Published
- 2006
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5. Reduced PM2.5 in Trujillo, Peru, on El Dia Sin Autos ('The Day Without Cars')
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Cassidy BE, Aguilar-Villalobos M, Ryan PB, and Naeher LP
- Abstract
Street-level and rooftop (three-story building) concentrations of particulate matter < or = 2.5 µm in diameter (PM2.5) were measured in downtown Trujillo, Peru, in July and August 2003 to determine the PM2.5 concentration reduction on days with normal traffic conditions (32 days) versus a day when motor vehicles were temporarily banned from the downtown district (8:00 a.m. to 6:00 p.m., July 15) known as El Dia Sin Autos ('The Day Without Cars'). The mean 8:00 a.m. to 6:00 p.m. street-level PM2.5 concentration during the motor vehicle ban (21.4 µg/m3; one day) was 49% lower than when vehicles were not impeded (42.2 ± 7.8 µg/m3 -- mean ± 1 standard deviation; 20 days). The rooftop monitoring station indicated a 20% decrease in PM2.5 concentrations (24.8 ± 2.6 µg/m3 vs. 19.9 ± 6.0 µg/m3) when motor vehicles were not present within historic downtown Trujillo. Temperature, relative humidity, and wind speed during the motor vehicle ban and during normal traffic were not significantly different (p > .05). [ABSTRACT FROM AUTHOR]
- Published
- 2010
6. 1-Nitropyrene Exposures in Air and Biomarker Levels in Urine Amongst Workers Exposed to Traffic-Related Air Pollution in Trujillo, Peru.
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Simpson, C D, Miller-Schulze, J, Paulsen, M, Kameda, T, Cassidy, B, Aguilar-Villalobos, M, and Naeher, L P
- Published
- 2008
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7. Exposure of pregnant women to cookstove-related household air pollution in urban and periurban Trujillo, Peru.
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St Helen G, Aguilar-Villalobos M, Adetona O, Cassidy B, Bayer CW, Hendry R, Hall DB, and Naeher LP
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- Adult, Carbon Monoxide analysis, Environmental Monitoring, Family Characteristics, Female, Humans, Nitrogen Dioxide analysis, Peru, Pregnancy, Smoke analysis, Volatile Organic Compounds analysis, Air Pollutants analysis, Air Pollution, Indoor analysis, Cooking methods, Maternal Exposure, Particulate Matter analysis
- Abstract
Although evidence suggests associations between maternal exposure to air pollution and adverse birth outcomes, pregnant women's exposure to household air pollution in developing countries is understudied. Personal exposures of pregnant women (N = 100) in Trujillo, Peru, to air pollutants and their indoor concentrations were measured. The effects of stove-use-related characteristics and ambient air pollution on exposure were determined using mixed-effects models. Significant differences in 48-hour kitchen concentrations of particulate matter (PM2.5), carbon monoxide (CO), and nitrogen dioxide (NO2) concentrations were observed across fuel types (p < 0.05). Geometric mean PM2.5 concentrations where 112 μg/m(3) (confidence limits [CLs]: 52, 242 μg/m(3)) and 42 μg/m(3) (21, 82 μg/m(3)) in homes where wood and gas were used, respectively. PM2.5 exposure was at levels that recent exposure-response analyses suggest may not result in substantial reduction in health risks even in homes where cleaner burning gas stoves were used.
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- 2015
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8. A Pilot Study Characterizing Real Time Exposures to Particulate Matter and Carbon Monoxide from Cookstove Related Woodsmoke in Rural Peru.
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Commodore AA, Hartinger SM, Lanata CF, Mäusezahl D, Gil AI, Hall DB, Aguilar-Villalobos M, and Naeher LP
- Abstract
Nearly half of the world's population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. We aimed to use PM
2.5 and CO measurements to characterize exposure to cookstove generated woodsmoke in real time among control (n=10) and intervention (n=9) households in San Marcos, Cajamarca Region, Peru. Real time personal particulate matter with an aerodynamic diameter ≤2.5 µm (PM2.5 ), and personal and kitchen carbon monoxide (CO) samples were taken. Control households used a number of stoves including open fire and chimney stoves while intervention households used study-promoted chimney stoves. Measurements were categorized into lunch (9am - 1pm) and dinner (3pm - 7pm) periods, where applicable, to adjust for a wide range of sampling periods (2.8- 13.1hrs). During the 4-h time periods, mean personal PM2.5 exposures were correlated with personal CO exposures during lunch (r=0.67 p=0.024 n=11) and dinner (r=0.72 p=0.0011 n=17) in all study households. Personal PM2.5 exposures and kitchen CO concentrations were also correlated during lunch (r=0.76 p=0.018 n=9) and dinner (r=0.60 p=0.018 n=15). CO may be a useful indicator of PM during 4-h time scales measured in real time, particularly during high woodsmoke exposures, particularly during residential biomass cooking.- Published
- 2013
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9. Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos, Peru.
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Commodore AA, Zhang JJ, Chang Y, Hartinger SM, Lanata CF, Mäusezahl D, Gil AI, Hall DB, Aguilar-Villalobos M, Vena JE, Wang JS, and Naeher LP
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- 8-Hydroxy-2'-Deoxyguanosine, Adult, Biomarkers urine, Creatinine pharmacology, Creatinine urine, Deoxyguanosine urine, Dinoprost urine, Female, Household Articles, Humans, Lipid Peroxidation, Oxidative Stress, Peru, Wood, Air Pollution analysis, Cooking, Deoxyguanosine analogs & derivatives, Dinoprost analogs & derivatives, Environmental Exposure analysis, Environmental Monitoring methods, Smoke
- Abstract
Nearly half of the world's population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. The effect of woodsmoke exposure on oxidative stress was examined by investigating the association between woodsmoke exposure and biomarkers of DNA oxidation (8-hydroxy-2'-deoxyguanosine [8-OHdG]) and lipid peroxidation (8-isoprostane) among control and intervention stove users. HAP exposure assessment was conducted within the framework of a community-randomized controlled trial of 51 communities in San Marcos Province, Cajamarca Region, Peru. The first morning urine voids after 48h HAP exposure assessment from a subset of 45 control and 39 intervention stove users were analyzed for 8-OHdG and 8-isoprostane. General linear models and correlation analyses were performed. Urinary oxidative stress biomarkers ranged from 11.2 to 2270.0μg/g creatinine (median: 132.6μg/g creatinine) for 8-OHdG and from 0.1 to 4.5μg/g creatinine (median: 0.8μg/g creatinine) for 8-isoprostane among all study subjects (n=84). After controlling for the effects of traffic in the community and eating food exposed to fire among all subjects, cooking time was weakly, but positively associated with urinary 8-OHdG (r=0.29, p=0.01, n=80). Subjects' real-time personal CO exposures were negatively associated with 8-OHdG, particularly the maximum 30-second CO exposure during the sampling period (r=-0.32, p=0.001, n=73). 48h time integrated personal PM2.5 was negatively, but marginally associated with urinary 8-isoprostane (r=-0.21, p=0.09, n=69) after controlling for the effect of distance of homes to the road. Urinary 8-isoprostane levels reported in the available literature are comparable to results found in the current study. However there were relatively high levels of urinary 8-OHdG compared to data in the available literature for 8-OHdG excretion. Results suggest a sustained systemic oxidative stress among these Peruvian women chronically exposed to wood smoke., (© 2013.)
- Published
- 2013
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10. Using exhaled carbon monoxide and carboxyhemoglobin to evaluate the effectiveness of a chimney stove model in Peru.
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Eppler AR, Fitzgerald C, Dorner SC, Aguilar-Villalobos M, Rathbun SL, Adetona O, and Naeher LP
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- Adult, Air Pollutants analysis, Air Pollution, Indoor analysis, Biomarkers, Environmental Exposure analysis, Female, Humans, Middle Aged, Particulate Matter analysis, Peru epidemiology, Carbon Monoxide analysis, Carboxyhemoglobin analysis, Cooking methods, Exhalation, Wood
- Abstract
Background: Measurement of biological indicators of physiological change may be useful in evaluating the effectiveness of stove models, which are intended to reduce indoor smoke exposure and potential health effects., Objectives: We examined changes in exhaled carbon monoxide (CO), percentage carboxy-hemoglobin, and total hemoglobin in response to the installation of a chimney stove model by the Juntos National Program in Huayatan, Peru in 2008., Methods: Biomarkers were measured in a convenience sample comprising 35 women who met requirements for participation, and were measured before and three weeks after installation of a chimney stove. The relationships between exposure to indoor smoke and biomarker measurements were also analyzed using simple linear regression models., Results: Exhaled CO reduced from 6.71 ppm (95% CI 5.84-7.71) to 3.14 ppm (95% CI 2.77-3.66) three weeks after stove installation (P < 0.001) while % COHb reduced from 1.76% (95% CI 1.62-1.91) to 1.18% (95% CI 1.12-1.25; P < 0.001). Changes in exhaled CO and % COHb from pre- to post-chimney stove installation were not correlated with corresponding changes in exposure to CO and PM2.5 even though the exposures also reduced after stove installation., Conclusion: Exhaled CO and % COHb both showed improvement with reduction in concentration after the installation of the chimney cook stoves, indicating a positive physiological response subsequent to the intervention.
- Published
- 2013
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11. Changes in the concentrations of biochemical indicators of diet and nutritional status of pregnant women across pregnancy trimesters in Trujillo, Peru, 2004-2005.
- Author
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Horton DK, Adetona O, Aguilar-Villalobos M, Cassidy BE, Pfeiffer CM, Schleicher RL, Caldwell KL, Needham LL, Rathbun SL, Vena JE, and Naeher LP
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- Adult, Carotenoids blood, Cryptoxanthins, Developing Countries, Female, Fetal Blood chemistry, Humans, Iron, Dietary blood, Linear Models, Lutein blood, Lycopene, Micronutrients blood, Micronutrients deficiency, Nutrition Surveys, Peru, Pregnancy, Selenium blood, Socioeconomic Factors, Surveys and Questionnaires, Vitamin A blood, Xanthophylls blood, Young Adult, Zeaxanthins, beta Carotene blood, Diet, Nutritional Status, Pregnancy Trimesters physiology
- Abstract
Background: In developing countries, deficiencies in essential micronutrients are common, particularly in pregnant women. Although, biochemical indicators of diet and nutrition are useful to assess nutritional status, few studies have examined such indicators throughout pregnancy in women in developing countries., Methods: The primary objective of this study was to assess the nutritional status of 78 Peruvian women throughout pregnancy for 16 different nutritional indicators including fat-soluble vitamins and carotenoids, iron-status indicators, and selenium. Venous blood samples from which serum was prepared were collected during trimesters one (n = 78), two (n = 65), three (n = 62), and at term via the umbilical cord (n = 52). Questionnaires were completed to determine the demographic characteristics of subjects. Linear mixed effects models were used to study the associations between each maternal indicator and the demographic characteristics., Results: None of the women were vitamin A and E deficient at any stage of pregnancy and only 1/62 women (1.6%) was selenium deficient during the third trimester. However, 6.4%, 44% and 64% of women had ferritin levels indicative of iron deficiency during the first, second and third trimester, respectively. Statistically significant changes (p ≤ 0.05) throughout pregnancy were noted for 15/16 nutritional indicators for this Peruvian cohort, with little-to-no association with demographic characteristics. Three carotenoids (beta-carotene, beta-cryptoxanthin and trans-lycopene) were significantly associated with education status, while trans-lycopene was associated with age and beta-cryptoxanthin with SES (p < 0.05). Concentrations of retinol, tocopherol, beta-cryptoxanthin, lutein + zeaxanthin and selenium were lower in cord serum compared with maternal serum (p < 0.05). Conversely, levels of iron status indicators (ferritin, transferrin saturation and iron) were higher in cord serum (p < 0.05)., Conclusion: The increasing prevalence of iron deficiency throughout pregnancy in these Peruvian women was expected. It was surprising though not to find deficiencies in other nutrients. The results highlight the importance of continual monitoring of women throughout pregnancy for iron deficiency which could be caused by increasing fetal needs and/or inadequate iron intake as pregnancy progresses.
- Published
- 2013
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12. Biomonitoring of polycyclic aromatic hydrocarbon exposure in pregnant women in Trujillo, Peru--comparison of different fuel types used for cooking.
- Author
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Adetona O, Li Z, Sjödin A, Romanoff LC, Aguilar-Villalobos M, Needham LL, Hall DB, Cassidy BE, and Naeher LP
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- Adult, Air Pollutants analysis, Air Pollution, Indoor statistics & numerical data, Carbon Monoxide analysis, Coal, Developing Countries, Female, Humans, Kerosene, Peru, Phenanthrenes analysis, Phenanthrenes urine, Polycyclic Aromatic Hydrocarbons analysis, Pregnancy, Pyrenes analysis, Pyrenes urine, Wood chemistry, Young Adult, Air Pollutants urine, Air Pollution, Indoor analysis, Cooking methods, Environmental Monitoring methods, Maternal Exposure statistics & numerical data, Polycyclic Aromatic Hydrocarbons urine
- Abstract
Women and children in developing countries are often exposed to high levels of air pollution including polycyclic aromatic hydrocarbons (PAHs), which may negatively impact their health, due to household combustion of biomass fuel for cooking and heating. We compared creatinine adjusted hydroxy-PAH (OH-PAH) concentrations in pregnant women in Trujillo, Peru who cook with wood to levels measured in those who cook with kerosene, liquefied petroleum gas or a combination of fuels. Seventy-nine women were recruited for the study between May and July 2004 in the first trimester of their pregnancy. Urine samples were collected from the subjects in the first, second and third trimesters for OH-PAH analyses. The concentrations of the OH-PAHs were compared across the type of fuel used for cooking and pregnancy trimesters. The relationships between OH-PAHs levels in the first trimester and concurrently measured personal exposures to PM₂.₅, carbon monoxide and nitrogen dioxide together with their indoor and outdoor air concentrations were also investigated. Women cooking with wood or kerosene had the highest creatinine adjusted OH-PAH concentrations compared with those using gas, coal briquette or a combination of fuels. Concentrations of creatinine adjusted 2-hydroxy-fluorene, 3-hydroxy-fluorene, 1-hydroxy-fluorene, 2-hydroxy-phenanthrene and 4-hydroxy-phenanthrene were significantly higher (p<0.05) in women who used wood or kerosene alone compared with women who used liquefied petroleum gas (LPG), coal briquette or a combination of fuels. An increase in the concentrations of creatinine adjusted 9-hydroxy-fluorene, 1-hydroxy-phenanthrene, 2-hydroxy-phenanthrene, 4-hydroxy-phenanthrene and 1-hydroxy-pyrene in the third trimesters was also observed. Weak positive correlation (Spearman correlation coefficient, ρ<0.4; p<0.05) was observed between all first trimester creatinine adjusted OH-PAHs and indoor (kitchen and living room), and personal 48-h TWA PM₂.₅. Women who cooked exclusively with wood or kerosene had higher creatinine adjusted OH-PAH levels in their urine samples compared to women who cooked with LPG or coal briquette., Competing Interests: statement The authors declare no conflict of interest., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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13. Carbon monoxide exposures and kitchen concentrations from cookstove-related woodsmoke in San Marcos, Peru.
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Commodore AA, Hartinger SM, Lanata CF, Mäusezahl D, Gil AI, Hall DB, Aguilar-Villalobos M, Butler CJ, and Naeher LP
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- Adult, Air Pollution, Indoor adverse effects, Air Pollution, Indoor statistics & numerical data, Carbon Monoxide adverse effects, Cross-Sectional Studies, Environmental Exposure adverse effects, Environmental Exposure statistics & numerical data, Environmental Monitoring, Female, Household Articles instrumentation, Humans, Peru epidemiology, Smoke adverse effects, Socioeconomic Factors, Air Pollution, Indoor analysis, Carbon Monoxide analysis, Cooking instrumentation, Environmental Exposure analysis, Smoke analysis, Wood
- Abstract
Background: Nearly half of the world's population is exposed to household air pollution (HAP) due to long hours spent in close proximity to biomass-fueled fires., Objective: We compare CO exposures and concentrations among study promoted intervention stove users and control stove users in San Marcos Province, Cajamarca region, Peru., Methods: Passive CO diffusion tubes were deployed over a 48-hour sampling period to measure kitchen CO concentrations and personal mother and child CO exposures in 197 control and 182 intervention households., Results: Geometric means (95% CI) for child, mother, and kitchen measurements were 1.1 (0.9-1.2), 1.4 (1.3-1.6), and 7.3 (6.4-8.3) ppm in control households, and 1.0 (0.9-1.1), 1.4 (1.3-1.6), and 7.3 (6.4-8.2) ppm among intervention households, respectively., Conclusion: With no significant differences between control and intervention CO measurements, results suggest that intervention stove maintenance may be necessary for long-term reductions in CO exposures.
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- 2013
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14. Testing the effectiveness of two improved cookstove interventions in the Santiago de Chuco Province of Peru.
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Fitzgerald C, Aguilar-Villalobos M, Eppler AR, Dorner SC, Rathbun SL, and Naeher LP
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- Air Pollution, Indoor analysis, Coal, Developing Countries, Heating, Humans, Inhalation Exposure analysis, Peru, Wood, Air Pollution, Indoor prevention & control, Cooking instrumentation, Inhalation Exposure prevention & control, Particulate Matter analysis, Smoke analysis
- Abstract
90% of people residing in rural areas of less-developed countries rely on coal and biomass fuels for heating and cooking, leading to high exposures to the products of incomplete combustion. Three Andean communities within the Santiago de Chuco province of Peru received two different models of improved cookstoves. The impact of these stoves in reducing personal exposures and kitchen concentrations of fine particulate matter (PM(2.5)) and carbon monoxide (CO) was evaluated separately in 64 homes (32 with each stove model) using air monitoring equipment. In the community receiving stove 1, baseline aggregate 48-h personal exposure (n=27) and kitchen concentrations (n=26) of PM(2.5) were 116.4 and 207.3μg/m(3), respectively, and 48-h personal (n=25) and kitchen (n=25) CO levels were 1.2 and 3.6ppm. After introducing the new stove to this community, those exposures reduced to 68.4 and 84.7μg/m(3), and 0.4 and 0.8ppm, representing reductions of 41.3%, 59.2%, 69.6% and 77.7% respectively. In the two communities receiving stove 2, corresponding levels were 126.3μg/m(3) (n=18), 173.4μg/m(3) (n=19), 0.9ppm (n=19), and 2.6ppm (n=17) before the installation of the stoves, and they reduced to 58.3, 51.1μg/m(3) and 0.6, 1.0ppm. Overall, homes receiving stove 2 saw reductions of 53.8, 70.5, 25.8 and 63.6%. All values are statistically significant (p<0.05) with the exception of personal CO reductions in the stove 2 group. Both stoves markedly reduce both kitchen and personal levels of wood smoke exposure, which we believe has the potential to improve health and quality of life., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2012
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15. Personal exposure to PM(2.5) and urinary hydroxy-PAH levels in bus drivers exposed to traffic exhaust, in Trujillo, Peru.
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Adetona O, Sjodin A, Zheng L, Romanoff LC, Aguilar-Villalobos M, Needham LL, Hall DB, Luis A, Cassidy BE, Simpson CD, and Naeher LP
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- Adult, Biomarkers urine, Fluorenes urine, Humans, Middle Aged, Motor Vehicles, Peru, Phenanthrenes urine, Time Factors, Vehicle Emissions, Air Pollutants analysis, Inhalation Exposure analysis, Occupational Exposure analysis, Particulate Matter analysis, Polycyclic Aromatic Hydrocarbons urine
- Abstract
Public transport vehicle drivers, especially in highly polluted or trafficked areas, are exposed to high levels of air pollutants. In this study, we assessed the influence of traffic on levels of hydroxy polycyclic aromatic hydrocarbons (OH-PAHs) in commercial bus drivers in Trujillo, Peru, by measuring the within-shift changes in the urinary whole weight and creatinine-corrected concentrations of the PAH metabolites. We measured personal PM(2.5) as a proxy of exposure to traffic emission. Urine samples were collected daily from two bus drivers and three minivan drivers in Trujillo, pre-, mid-, post-work shift and on days when the drivers were off work (total n = 144). Ten OH-PAH metabolites were measured in the urine samples. Drivers were also monitored for exposure to PM(2.5) (n = 41). Daily work shift (mean = 13.1 ± 1.3 hr) integrated PM(2.5) was measured in the breathing zones of the drivers for an average of 10.5 days per driver. The differences across shift in OH-PAH concentrations were not statistically significant except for urinary 2-hydroxyfluorene (2-FLU) (p = 0.04) and 4-hydroxyphenanthrene (4-PHE) (p = 0.01) and creatinine-corrected 4-hydroxyphenanthrene (p = 0.01). Correlation between pairs of hydroxy-PAHs (ρ = 0.50 to 0.93) were highest for mid-shift samples. Concentrations of PM(2.5) (geometric mean = 64 μg/m(3); 95% confidence limits = 52 μg/m(3), 78 μg/m(3)) is similar to those measured in many other studies of traffic exposure. There was significant change across work shift for concentrations of only two of the OH-PAHs (2-FLU and 4-PHE). Results indicate that the drivers may have had limited time for clearance of PAH exposure from the body between work shifts. Comparisons of the concentrations of creatinine-corrected hydroxy-PAH to those reported in other studies indicate that exposure of public transport drivers to PAH could be similar. By following the subjects over multiple days, this study gives an indication of appropriate exposure situations for the use of hydroxy-PAHs and will be beneficial in designing future occupational studies of PAH exposure.
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- 2012
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16. Evaluation of exposure reduction to indoor air pollution in stove intervention projects in Peru by urinary biomonitoring of polycyclic aromatic hydrocarbon metabolites.
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Li Z, Sjödin A, Romanoff LC, Horton K, Fitzgerald CL, Eppler A, Aguilar-Villalobos M, and Naeher LP
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- Adult, Air Pollution, Indoor analysis, Biomass, Carbon Monoxide analysis, Cooking, Environmental Monitoring, Female, Fires, Humans, Inhalation Exposure prevention & control, Inhalation Exposure statistics & numerical data, Middle Aged, Nutrition Surveys, Particulate Matter analysis, Peru, Polycyclic Aromatic Hydrocarbons analysis, Wood, Young Adult, Air Pollution, Indoor statistics & numerical data, Carbon Monoxide urine, Household Articles, Inhalation Exposure analysis, Particulate Matter urine, Polycyclic Aromatic Hydrocarbons urine
- Abstract
Burning biomass fuels such as wood on indoor open-pit stoves is common in developing regions. In such settings, exposure to harmful combustion products such as fine particulate matter (PM(2.5)), carbon monoxide (CO) and polycyclic aromatic hydrocarbons (PAHs) is of concern. We aimed to investigate if the replacement of open pit stoves by improved stoves equipped with a chimney would significantly reduce exposure to PAHs, PM(2.5) and CO. Two stove projects were evaluated in Peru. Program A was part of the Juntos National Program in which households built their own stoves using materials provided. In Program B, Barrick Gold Corporation hired a company to produce and install the stoves locally. A total of 30 and 27 homes participated in Program A and B, respectively. We collected personal and kitchen air samples, as well as morning urine samples from women tasked with cooking in the households before and after the installation of the improved stoves. Median levels of PM(2.5) and CO were significantly reduced in kitchen and personal air samples by 47-74% after the installation of the new stoves, while the median reduction of 10 urinary hydroxylate PAH metabolites (OH-PAHs) was 19%-52%. The observed OH-PAH concentration in this study was comparable or higher than the 95th percentile of the general U.S. population, even after the stove intervention, indicating a high overall exposure in this population., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Published
- 2011
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17. An estimate of phthalate exposure among pregnant women living in Trujillo, Peru.
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Irvin EA, Calafat AM, Silva MJ, Aguilar-Villalobos M, Needham LL, Hall DB, Cassidy B, and Naeher LP
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- Adolescent, Adult, Environmental Pollutants blood, Environmental Pollutants urine, Female, Humans, Middle Aged, Peru, Phthalic Acids blood, Phthalic Acids urine, Pregnancy, Young Adult, Environmental Monitoring, Environmental Pollutants metabolism, Maternal Exposure statistics & numerical data, Phthalic Acids metabolism, Plasticizers metabolism
- Abstract
Phthalates are a group of phthalic acid esters which are used as plasticizers and additives. In laboratory animals, several phthalates are known endocrine disruptors. Several studies have described phthalate exposure in the United States and developed countries but little is known about phthalate exposure in the developing world, particularly during pregnancy. To assess exposure to six different phthalates, we measured the concentrations of nine phthalate metabolites in spot urine samples collected during the first, second, and third trimester of pregnancy from a group of 72 women living in Trujillo, Peru. Additionally, women completed questionnaires to provide demographic characteristics. Statistical analysis via linear models was used to evaluate potential differences in the concentrations of phthalate metabolites by trimester, cooking fuel type, socioeconomic status, and education. All metabolites were detected in>40% of samples analyzed, and mono-n-butyl phthalate, mono (2-ethyl-5-carboxypentyl) phthalate, and monoethyl phthalate were found in>90% of samples. Five of nine unadjusted urinary metabolites and four of nine creatinine-adjusted urinary metabolites were significantly lower in this group of pregnant women living in Peru compared to pregnant women in the US general population., (Copyright (c) 2010 Elsevier Ltd. All rights reserved.)
- Published
- 2010
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18. Residential exposures to PM2.5 and CO in Cusco, a high-altitude city in the Peruvian Andes: a pilot study.
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Pearce JL, Aguilar-Villalobos M, Rathbun SL, and Naeher LP
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- Cluster Analysis, Developing Countries, Housing, Humans, Peru epidemiology, Pilot Projects, Urban Population, Air Pollutants analysis, Air Pollution, Indoor analysis, Altitude, Carbon Monoxide analysis, Environmental Exposure analysis, Particulate Matter analysis
- Abstract
High-altitude populations using biofuels for household energy may be at health risk due to a combination of altitudinal stress and indoor exposures to biomass smoke. In this article, the authors measure indoor and outdoor breathing level concentrations of PM(2.5) and CO during periods of meal preparation in a convenience sample of homes above 3000 m in Cusco, Peru. From July 10 to 21, 2005, 237 measurements were taken during a pilot study at 41 residences. Results show the highest levels of PM(2.5) and CO occurred during the early morning in the kitchen when dung and wood were used. Additionally, findings suggest that residential biomass fuel combustion in Cusco results in elevated indoor PM(2.5) and CO exposure levels that are of potential human health concern, an issue that may be exacerbated by the physiological impact of living in a high-altitude environment.
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- 2009
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19. A pilot study to assess residential endotoxin and blood IgE in a group of pregnant women from Trujillo, Peru.
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Visser MC, Ownby D, Aguilar-Villalobos M, Needham LL, and Naeher LP
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- Adolescent, Adult, Female, Humans, Life Style, Middle Aged, Peru, Pilot Projects, Pregnancy, Surveys and Questionnaires, Endotoxins analysis, Immunoglobulin E blood
- Abstract
Objective: This November 2003 pilot study investigates the correlation between serum IgE and residential endotoxin levels from a group of 18 pregnant women living in Trujillo, Peru, and investigates the impact of the demographic and lifestyle factors of this group on the IgE and endotoxin levels measured., Methods: Serum samples were collected from 19 subjects and analyzed for IgE. Dust samples were collected from the mattresses of 18 subjects and measured for endotoxin levels. A questionnaire was used to obtain demographic, socioeconomic, and lifestyle information for each subject., Results: Geometric means for IgE and endotoxin were 246.8 (GSD=4.3, n=19) IU/mL and 66.5 EU/mg (GSD=1.7, n=18), respectively. Log-transformed IgE and endotoxin were not correlated (R2=0.02; p=0.60)., Conclusions: Residential endotoxin and serum IgE were not correlated in this group. Potential selection bias and sample size are major limitations of the study. However, 74% (14/19) of the subjects in this study had an IgE over 100 IU/mL, a level generally considered elevated.
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- 2007
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20. Perfluorinated chemicals in selected residents of the American continent.
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Calafat AM, Needham LL, Kuklenyik Z, Reidy JA, Tully JS, Aguilar-Villalobos M, and Naeher LP
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- Adult, Blood Donors, Environmental Monitoring, Female, Humans, Male, Peru, Quality Control, United States, Fluorocarbons blood
- Abstract
Perfluorinated chemicals (PFCs) are used in multiple consumer products. Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), the most widely studied PFCs, may be potential developmental, reproductive, and systemic toxicants. Although PFCs seem to be ubiquitous contaminants found both in humans and animals, geographic differences may exist in human exposure patterns to PFCs. We measured 11 PFCs in 23 pooled serum samples collected in the United States from 1990 through 2002, and in serum samples collected in 2003 from 44 residents from Trujillo, Peru. PFOS and PFOA were detected in all the pooled samples; perfluorohexane sulfonic acid (PFHxS) was detected in 21. Median concentrations were 31.1 micrograms per liter (mug/l, PFOS), 11.6 microg/l (PFOA), and 2 microg/l (PFHxS). The 90th percentile concentrations of PFCs in the 44 Peruvian residents were 0.7 microg/l (PFOS), 0.1 microg/l (PFOA), and <0.3 microg/l (PFHxS). The frequencies of detection were 20% (PFOS), 25% (PFOA), and 9% (PFHxS). The frequent detection of selected PFCs in the pooled samples from the United States and the lack of clear concentration trends based on a year of collection suggest a sustained widespread exposure to these compounds among US residents, at least since the 1990s. By contrast, the much lower frequency of detection and concentration ranges of PFCs in Peru suggest a lower exposure of Peruvians to PFCs compared with North Americans. Genetic variability, diet, lifestyle, or a combination of all these may contribute to the different patterns of human exposure to PFCs in the United States and Peru.
- Published
- 2006
- Full Text
- View/download PDF
21. Traffic-related occupational exposures to PM2.5, CO, and VOCs in Trujillo, Peru.
- Author
-
Han X, Aguilar-Villalobos M, Allen J, Carlton CS, Robinson R, Bayer C, and Naeher LP
- Subjects
- Humans, Particle Size, Peru epidemiology, Pilot Projects, Volatilization, Air Pollutants, Occupational adverse effects, Carbon Monoxide adverse effects, Occupational Exposure, Vehicle Emissions adverse effects
- Abstract
A traffic-related exposure study was conducted among 58 workers (drivers, vendors, traffic police, and gas station attendants) and 10 office workers as controls in Trujillo, Peru, in July 2002. PM2.5 was collected, carbon monoxide (CO) was measured, volatile organic compounds (VOCs) were sampled and analyzed. Newspaper vendors had the highest full-shift CO exposures (mean +/- SD: 11.4 +/- 8.9 ppm), while office workers had the lowest (2.0 +/- 1.7 ppm). Bus drivers had the highest full-shift PM2.5 exposures (161 +/- 8.9 microg/m3), while gas station attendants (64 +/- 26.5 microg/m3) and office workers (65 +/- 8.5 microg/m3) were the lowest. Full-shift benzene/toluene/ethylbenzene/xylene exposures (BTEX) among gas station attendants (111/254/43/214 microg/m3) were much higher than those among van and taxi drivers. Several of the traffic-related occupational exposures studied were elevated and are of occupational health concern.
- Published
- 2005
- Full Text
- View/download PDF
22. Blood lead survey of children, pregnant women, professional drivers, street workers, and office workers in Trujillo, Peru.
- Author
-
Naeher LP, Aguilar-Villalobos M, and Miller T
- Subjects
- Adult, Air Pollutants blood, Air Pollutants, Occupational blood, Case-Control Studies, Child, Data Collection, Female, Gasoline toxicity, Humans, Interviews as Topic, Male, Peru, Pregnancy, Seasons, Surveys and Questionnaires, Urban Health, Air Pollutants toxicity, Air Pollutants, Occupational toxicity, Environmental Exposure adverse effects, Gasoline supply & distribution, Lead blood, Transportation, Vehicle Emissions toxicity, Workplace
- Abstract
In this pilot study, conducted in summer 2002, the authors measured blood lead levels (BLLs) for 118 subjects in the city of Trujillo, Peru, where leaded gasoline is in the process of being phased out. Subjects included bus drivers, combi (minivan) drivers, street vendors, newspaper vendors, traffic police, taxi drivers, gas station attendants, children living both near and distant from gas stations, pregnant women, and office workers (controls). The highest BLLs were 9.2 microg/dl and 9.3 microg/dl from a child who lived near a gas station and from a traffic policeman, respectively; however, all BLLs were below the U.S. Centers for Disease Control and Prevention's advisory level of concern (10 microg/dl). Office workers (n = 8) and pregnant women (n = 36) had significantly lower BLLs (geometric mean +/- standard deviation = 2.1 +/- 0.7 microg/dl, p < 0.022; and 2.5 +/- 1.1 microg/dl, p < 0.008, respectively) than total traffic-exposed workers (n = 48; 3.2 +/- 1.8 microg/dl). BLLs of children living near gas stations (n = 17; 3.7 +/- 2.2 microg/dl) were marginally higher (p = 0.07) than for children not living near gas stations (n = 9; 2.9 +/- 1.1 microg/dl). The study was limited by small sample size and the fact that the data were based on a convenience sample not fully representative of the cohorts studied. Nevertheless, the authors' findings suggest that leaded gasoline use in Trujillo continues to affect BLLs in traffic-exposed populations.
- Published
- 2004
- Full Text
- View/download PDF
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