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2. Interaction between genetic risk score and dietary carbohydrate intake on high-density lipoprotein cholesterol levels: Findings from the study of obesity, nutrition, genes and social factors (SONGS)

Author

Wuni, Ramatu, Curi-Quinto, Katherine, Liu, Litai, Espinoza, Dianela, Aquino, Anthony I., del Valle-Mendoza, Juana, Aguilar-Luis, Miguel Angel, Murray, Claudia, Nunes, Richard, Methven, Lisa, Lovegrove, Julie A., Penny, Mary, Favara, Marta, Sánchez, Alan, and Vimaleswaran, Karani Santhanakrishnan

Published
2025
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7. Leptospira spp. and Rickettsia spp. as pathogens with zoonotic potential causing acute undifferentiated febrile illness in a central-eastern region of Peru

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. eb-POLICOM - Polímers i Compòsits Ecològics i Biodegradables, Silva Caso, Wilmer, Aguilar Luis, Miguel Angel, Espinoza Espíritu, Walter, Vilcapoma Balbin, Mercedes, Valle Mendoza, Luis Javier del, Misaico Revate, Erika, Soto Febres, Fernando, Pérez Lazo, Giancarlo, Martins Luna, Johanna Elizabeth, Perona Fajardo, Francisco, Del Valle Mendoza, Juana, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. eb-POLICOM - Polímers i Compòsits Ecològics i Biodegradables, Silva Caso, Wilmer, Aguilar Luis, Miguel Angel, Espinoza Espíritu, Walter, Vilcapoma Balbin, Mercedes, Valle Mendoza, Luis Javier del, Misaico Revate, Erika, Soto Febres, Fernando, Pérez Lazo, Giancarlo, Martins Luna, Johanna Elizabeth, Perona Fajardo, Francisco, and Del Valle Mendoza, Juana

Abstract

This study was to determine the relationship between acute febrile illness and bacterial pathogens with zoonotic potential that cause emerging and re-emerging diseases in a central-eastern region of Peru., Postprint (published version)

Published
2024

8. Parasitosis by fasciola hepatica and variations in gut microbiota in school-aged children from Peru

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. eb-POLICOM - Polímers i Compòsits Ecològics i Biodegradables, Silva Caso, Wilmer, Carrillo Ng, Hugo, Aguilar Luis, Miguel Angel, Tarazona Castro, Yordi Qesler, Valle Mendoza, Luis Javier del, Tinco Valdez, Carmen, Palomares Reyes, Carlos, Urteaga, Numan, Bazan Mayra, Jorge, Del Valle Mendoza, Juana, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. eb-POLICOM - Polímers i Compòsits Ecològics i Biodegradables, Silva Caso, Wilmer, Carrillo Ng, Hugo, Aguilar Luis, Miguel Angel, Tarazona Castro, Yordi Qesler, Valle Mendoza, Luis Javier del, Tinco Valdez, Carmen, Palomares Reyes, Carlos, Urteaga, Numan, Bazan Mayra, Jorge, and Del Valle Mendoza, Juana

Abstract

Background: Human fascioliasis is considered an endemic and hyper-endemic disease in the Peruvian Andean valleys. Our objective was to determine variations in the composition of the gut microbiota among children with Fasciola hepatica and children who do not have this parasitosis. Method: A secondary analysis was performed using fecal samples stored in our biobank. The samples were collected as part of an epidemiological Fasciola hepatica cross-sectional study in children from 4 through 14 years old from a community in Cajamarca, Peru. Results: In a comparison of the bacterial genera that make up the intestinal microbiota between the F. hepatica positive and negative groups, it was found that there are significant differences in the determination of Lactobacillus (p = 0.010, CI: 8.5–61.4), Bacteroides (p = 0.020, CI: 18.5–61.4), Clostridium (p < 0.001, CI: 3.5–36.0), and Bifidobacterium (p = 0.018, CI: 1.1–28.3), with each of these genera being less frequent in children parasitized with F. hepatica. (4) Conclusions: These results show that F. hepatica may be associated with direct or indirect changes in the bacterial population of the intestinal microbiota, particularly affecting three bacterial genera., Postprint (published version)

Published
2024

9. Identification and clinical characteristics of community-acquired acinetobacter baumannii in patients hospitalized for moderate or severe COVID-19 in Peru

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. eb-POLICOM - Polímers i Compòsits Ecològics i Biodegradables, Silva Caso, Wilmer, Pérez Lazo, Giancarlo, Aguilar Luis, Miguel Angel, Morales Moreno, Adriana, Ballena López, José, Soto Febres, Fernando, Martins Luna, Johanna Elizabeth, Valle Mendoza, Luis Javier del, Kym, Sungmin, Aguilar Luis, Deysi, Denegri Hinostroza, Dayana, Del Valle Mendoza, Juana, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. eb-POLICOM - Polímers i Compòsits Ecològics i Biodegradables, Silva Caso, Wilmer, Pérez Lazo, Giancarlo, Aguilar Luis, Miguel Angel, Morales Moreno, Adriana, Ballena López, José, Soto Febres, Fernando, Martins Luna, Johanna Elizabeth, Valle Mendoza, Luis Javier del, Kym, Sungmin, Aguilar Luis, Deysi, Denegri Hinostroza, Dayana, and Del Valle Mendoza, Juana

Abstract

Acinetobacter baumannii has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment. A. baumannii was detected via the PCR amplification of the blaOXA-51 gene obtained from nasopharyngeal swabs within 48 h of hospitalization. A total of 295 patients with COVID-19 who met the study inclusion criteria were enrolled. A. baumannii was simultaneously identified in 40/295 (13.5%) of COVID-19-hospitalized patients. Demographic data and comorbidities were comparable in both Acinetobacter-positive and -negative subgroups. However, patients identified as being infected with Acinetobacter were more likely to have received outpatient antibiotics prior to hospitalization, had a higher requirement for high-flow nasal cannula and a higher subjective incidence of fatigue, and were more likely to develop Acinetobacter-induced pneumonia during hospitalization. Conclusions: The group in which SARS-CoV-2 and A. baumannii were simultaneously identified had a higher proportion of fatigue, a higher frequency of requiring a high-flow cannula, and a higher proportion of superinfection with the same microorganism during hospitalization., Postprint (published version)

Published
2024

12. Identification and Clinical Characteristics of Community-Acquired Acinetobacter baumannii in Patients Hospitalized for Moderate or Severe COVID-19 in Peru

Author

Silva-Caso, Wilmer, primary, Pérez-Lazo, Giancarlo, additional, Aguilar-Luis, Miguel Angel, additional, Morales-Moreno, Adriana, additional, Ballena-López, José, additional, Soto-Febres, Fernando, additional, Martins-Luna, Johanna, additional, Del Valle, Luis J., additional, Kym, Sungmin, additional, Aguilar-Luis, Deysi, additional, Denegri-Hinostroza, Dayana, additional, and del Valle-Mendoza, Juana, additional

Published
2024
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19. Analysis of Ferritin, Hepcidin, Zinc, C-Reactive Protein and IL-6 Levels in COVID-19 in Patients Living at Different Altitudes in Peru.

Author

Silva-Caso, Wilmer, Kym, Sungmin, Merino-Luna, Alfredo, Aguilar-Luis, Miguel Angel, Tarazona-Castro, Yordi, Carrillo-Ng, Hugo, Bonifacio-Velez de Villa, Eliezer, Aquino-Ortega, Ronald, and del Valle-Mendoza, Juana

Subjects
COVID-19, HEPCIDIN, C-reactive protein, CITIES & towns, FERRITIN
Abstract

Background: Despite great scientific efforts, understanding the role of COVID-19 clinical biomarkers remains a challenge. Methods: A cross-sectional descriptive study in two Peruvian cities at different altitudes for comparison: Lima and Huaraz. In each place, three groups were formed, made up of 25 patients with COVID-19 in the ICU, 25 hospitalized patients with COVID-19 who did not require the ICU, and 25 healthy subjects as a control group. Five biomarkers were measured: IL-6, hepcidin, ferritin, C-reactive protein, and zinc using ELISA assays. Results: Ferritin, C-reactive protein, and IL-6 levels were significantly higher in the ICU and non-ICU groups at both study sites. In the case of hepcidin, the levels were significantly higher in the ICU group at both study sites compared to the non-ICU group. Among the groups within each study site, the highest altitude area presented statistically significant differences between its groups in all the markers evaluated. In the lower altitude area, differences were only observed between the groups for the zinc biomarker. Conclusion: COVID-19 patients residing at high altitudes tend to have higher levels of zinc and IL-6 in all groups studied compared to their lower altitude counterparts. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The Chikungunya virus: A reemerging cause of acute febrile illness in the high jungle of northern Peru

Author

Aguilar-Luis, Miguel Angel, primary, Watson, Hugh, additional, Tarazona-Castro, Yordi, additional, Troyes-Rivera, Lucinda, additional, Cabellos-Altamirano, Felipe, additional, Silva-Caso, Wilmer, additional, Aquino-Ortega, Ronald, additional, Carrillo-Ng, Hugo, additional, Zavaleta-Gavidia, Victor, additional, and del Valle-Mendoza, Juana, additional

Published
2023
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23. Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized

Author

Saiki-Macedo, Stephanie, Valverde-Ezeta, Jorge, Cornejo-Tapia, Angela, Castillo, Maria Esther, Petrozzi-Helasvuo, Verónica, Aguilar-Luis, Miguel Angel, del Valle, Luis J., Cieza-Mora, Erico, Bada, Carlos, del Aguila, Olguita, Silva-Caso, Wilmer, Martins-Luna, Johanna, Vasquez-Achaya, Fernando, and del Valle-Mendoza, Juana

Published
2019
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25. Parasitosis by Fasciola hepatica and Variations in Gut Microbiota in School-Aged Children from Peru.

Author

Silva-Caso, Wilmer, Carrillo-Ng, Hugo, Aguilar-Luis, Miguel Angel, Tarazona-Castro, Yordi, Valle, Luis J. Del, Tinco-Valdez, Carmen, Palomares-Reyes, Carlos, Urteaga, Numan, Bazán-Mayra, Jorge, and Valle-Mendoza, Juana del

Subjects
FASCIOLA hepatica, GUT microbiome, FASCIOLIASIS, ENDEMIC diseases, BACTERIAL population, SCHOOL children
Abstract

(1) Background: Human fascioliasis is considered an endemic and hyper-endemic disease in the Peruvian Andean valleys. Our objective was to determine variations in the composition of the gut microbiota among children with Fasciola hepatica and children who do not have this parasitosis. (2) Method: A secondary analysis was performed using fecal samples stored in our biobank. The samples were collected as part of an epidemiological Fasciola hepatica cross-sectional study in children from 4 through 14 years old from a community in Cajamarca, Peru. (3) Results: In a comparison of the bacterial genera that make up the intestinal microbiota between the F. hepatica positive and negative groups, it was found that there are significant differences in the determination of Lactobacillus (p = 0.010, CI: 8.5–61.4), Bacteroides (p = 0.020, CI: 18.5–61.4), Clostridium (p < 0.001, CI: 3.5–36.0), and Bifidobacterium (p = 0.018, CI: 1.1–28.3), with each of these genera being less frequent in children parasitized with F. hepatica. (4) Conclusions: These results show that F. hepatica may be associated with direct or indirect changes in the bacterial population of the intestinal microbiota, particularly affecting three bacterial genera. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Effect of Phenylalanine–Arginine Beta-Naphthylamide on the Values of Minimum Inhibitory Concentration of Quinolones and Aminoglycosides in Clinical Isolates of Acinetobacter baumannii

Author

Plasencia-Rebata, Stefany, primary, Levy-Blitchtein, Saul, additional, del Valle-Mendoza, Juana, additional, Silva-Caso, Wilmer, additional, Peña-Tuesta, Isaac, additional, Vicente Taboada, William, additional, Barreda Bolaños, Fernando, additional, and Aguilar-Luis, Miguel Angel, additional

Published
2023
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36. Rapid method for counting of blood leukocytes and its usefulness in health status assessment of rainbow trout (Oncorhynchus mykiss)/Metodo rapido para la cuantificacion de leucocitos sanguineos y su utilidad en la evaluacion del estado de salud en trucha arcoiris Oncorhynchus mykiss

Author

Alzamora-Gonzales, Libertad, Amat-Herbozo, Carolina de, Colona-Vallejos, Erasmo, Cervantes-Aguilar, Elizabeth, Velarde-Alvarez, Richard Dyer, Aquino-Ortega, Ronald, and Aguilar-Luis, Miguel Angel

Published
2015
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39. Detection of SARS-CoV-2 antibodies in febrile patients from an endemic region of dengue and chikungunya in Peru

Author

Tarazona-Castro, Yordi, Troyes-Rivera, Lucinda, Martins-Luna, Johanna, Cabellos-Altamirano, Felipe, Aguilar-Luis, Miguel Angel, Carrillo-Ng, Hugo, Del Valle, Luis J., Kym, Sungmin, Miranda-Maravi, Sebastian, Silva-Caso, Wilmer, and Show all

Subjects
Dengue, Fever, Coinfection, Show all, COVID-19, Humans, Cross-Sectional studies, Arthralgia, Chikungunya fever, Chikungunya virus, Antibodies
Abstract

Introduction The rapid expansion of the novel SARS-CoV-2 virus has raised serious public health concerns due to the possibility of misdiagnosis in regions where arboviral diseases are endemic. We performed the first study in northern Peru to describe the detection of SARSCoV-2 IgM antibodies in febrile patients with a suspected diagnosis of dengue and chikungunya fever. Materials and methods A consecutive cross-sectional study was performed in febrile patients attending primary healthcare centers from April 2020 through March 2021. Patients enrolled underwent serum sample collection for the molecular and serological detection of DENV and CHIKV. Also, serological detection of IgM antibodies against SARS-CoV-2 was performed. Results 464 patients were included during the study period, of which (40.51%) were positive for one pathogen, meanwhile (6.90%) presented co-infections between 2 or more pathogens. The majority of patients with monoinfections were positive for SARS-CoV-2 IgM with (73.40%), followed by DENV 18.09% and CHIKV (8.51%). The most frequent co-infection was DENV + SARS-CoV-2 with (65.63%), followed by DENV + CHIKV and DENV + CHIKV + SARSCoV-2, both with (12.50%). The presence of polyarthralgias in hands (43.75%, p

Published
2022

40. Detection of SARS-CoV-2 antibodies in febrile patients from an endemic region of dengue and chikungunya in Peru

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables, Tarazona Castro, Yordi Qesler, Troyes Rivera, Lucinda, Martins Luna, Johanna Elizabeth, Cabellos Altamirano, Felipe, Aguilar Luis, Miguel Angel, Carrillo Ng, Hugo, Valle Mendoza, Luis Javier del, Kym, Sungmin, Miranda Maravi, Sebastian, Silva Caso, Wilmer, Levi Blitchtein, Saul, Valle Mendoza, Juana del, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables, Tarazona Castro, Yordi Qesler, Troyes Rivera, Lucinda, Martins Luna, Johanna Elizabeth, Cabellos Altamirano, Felipe, Aguilar Luis, Miguel Angel, Carrillo Ng, Hugo, Valle Mendoza, Luis Javier del, Kym, Sungmin, Miranda Maravi, Sebastian, Silva Caso, Wilmer, Levi Blitchtein, Saul, and Valle Mendoza, Juana del

Abstract

Introduction: The rapid expansion of the novel SARS-CoV-2 virus has raised serious public health concerns due to the possibility of misdiagnosis in regions where arboviral diseases are endemic. We performed the first study in northern Peru to describe the detection of SARS-CoV-2 IgM antibodies in febrile patients with a suspected diagnosis of dengue and chikungunya fever. Materials and methods: A consecutive cross-sectional study was performed in febrile patients attending primary healthcare centers from April 2020 through March 2021. Patients enrolled underwent serum sample collection for the molecular and serological detection of DENV and CHIKV. Also, serological detection of IgM antibodies against SARS-CoV-2 was performed. Results: 464 patients were included during the study period, of which (40.51%) were positive for one pathogen, meanwhile (6.90%) presented co-infections between 2 or more pathogens. The majority of patients with monoinfections were positive for SARS-CoV-2 IgM with (73.40%), followed by DENV 18.09% and CHIKV (8.51%). The most frequent co-infection was DENV + SARS-CoV-2 with (65.63%), followed by DENV + CHIKV and DENV + CHIKV + SARS-CoV-2, both with (12.50%). The presence of polyarthralgias in hands (43.75%, p<0.01) and feet (31.25%, p = 0.05) were more frequently reported in patients with CHIKV monoinfection. Also, conjunctivitis was more common in patients positive for SARS-CoV-2 IgM (11.45%, p<0.01). The rest of the symptoms were similar among all the study groups. Conclusion: SARS-CoV-2 IgM antibodies were frequently detected in acute sera from febrile patients with a clinical suspicion of arboviral disease. The presence of polyarthralgias in hands and feet may be suggestive of CHIKV infection. These results reaffirm the need to consider SARS-CoV-2 infection as a main differential diagnosis of acute febrile illness in arboviruses endemic areas, as well as to consider co-infections between these pathogens., Postprint (published version)

Published
2022

41. Comparison of cytokines levels among COVID-19 patients living at sea level and high altitude

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables, Valle Mendoza, Juana del, Tarazona Castro, Yordi Qesler, Carrillo Ng, Hugo, Kym, Sungmin, Aguilar Luis, Miguel Angel, Valle Mendoza, Luis Javier del, Aquino Ortega, Ronald, Martins Luna, Johanna Elizabeth, Peña Tuesta, Isaac, Silva Caso, Wilmer, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables, Valle Mendoza, Juana del, Tarazona Castro, Yordi Qesler, Carrillo Ng, Hugo, Kym, Sungmin, Aguilar Luis, Miguel Angel, Valle Mendoza, Luis Javier del, Aquino Ortega, Ronald, Martins Luna, Johanna Elizabeth, Peña Tuesta, Isaac, and Silva Caso, Wilmer

Abstract

Background: At the end of 2019, a novel coronavirus denominated SARS-CoV-2 rapidly spread through the world causing the pandemic coronavirus disease known as COVID-19. The difference in the inflammatory response against SARS-CoV-2 infection among people living at different altitudes is a variable not yet studied. Methods: A descriptive cross-sectional study was performed in two Peruvian cities at different altitudes for compari- son: Lima and Huaraz. Five important proinflammatory cytokines were measured including: IL-6, IL-2, IL-10, IFN-¿ and TNF-a using ELISA assays. Results: A total of 35 COVID-19 patients and 10 healthy subjects were recruited from each study site. The mean levels of IL-6 (p < 0.03) and TNF-a (p < 0.01) were significantly different among the study groups. In the case of IL-6, patients from Lima had a mean level of 16.2 pg/ml (healthy) and 48.3 pg/ml (COVID-19), meanwhile, patients from Huaraz had levels of 67.3 pg/ml (healthy) and 97.9 pg/ml (COVID-19). Regarding TNF-a, patients from Lima had a mean level of 25.9 pg/ml (healthy) and 61.6 pg/ml (COVID-19), meanwhile, patients from Huaraz had levels of 89.0 pg/ml (healthy) and 120.6 pg/ml (COVID-19). The levels of IL-2, IL-10 and IFN-¿ were not significantly different in the study groups. Conclusion: Patients with COVID-19 residing at high-altitude tend to have higher levels of inflammatory cytokines compared to patients living at sea level, particularly IL-6 and TNF-a. A better understanding of the inflammatory response in different populations can contribute to the implementation of therapeutic and preventive approaches. Further studies evaluating more patients, a greater variety of cytokines and their clinical impact are required., Postprint (published version)

Published
2022

42. Detection of SARS-CoV-2 antibodies in febrile patients from an endemic region of dengue and chikungunya in Peru

Author

Tarazona-Castro, Yordi, primary, Troyes-Rivera, Lucinda, additional, Martins-Luna, Johanna, additional, Cabellos-Altamirano, Felipe, additional, Aguilar-Luis, Miguel Angel, additional, Carrillo-Ng, Hugo, additional, del Valle, Luis J., additional, Kym, Sungmin, additional, Miranda-Maravi, Sebastian, additional, Silva-Caso, Wilmer, additional, Levy-Blitchtein, Saul, additional, and del Valle-Mendoza, Juana, additional

Published
2022
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43. Impact of Adding a Rapid PCR-Based Blood Culture Identification Panel to the Antimicrobial Stewardship Program of Patients with Febrile Neutropenia in a Peruvian Referral Hospital.

Author

Pérez-Lazo, Giancarlo, del Valle-Mendoza, Juana, Sandoval-Ahumada, Roxana, Soto-Febres, Fernando, Castillo-Córdova, Raúl, Zárate-Tantaleán, Melissa, Morales-Castillo, Liliana, Páucar-Miranda, Celia Joanna, Altamirano-Molina, Milagros, Pacheco-Modesto, Iván, Ruiz de Somocurcio-Cruzado, Claudia, Arana-Jurado, Denis, del Villar-Alarcón, Carmen, Vargas-Castro, Olga, Díaz-Bardales, Carol, Guerrero-Arismendiz, Bruno, Eyzaguirre-Zapata, Renee, Aguilar-Luis, Miguel Angel, Martins-Luna, Johanna, and Silva-Caso, Wilmer

Subjects
FEBRILE neutropenia, ANTIMICROBIAL stewardship, PATIENT readmissions, HOSPITAL mortality, HOSPITALS
Abstract

The addition of Biofire® FilmArray® Blood Culture Identification panel 2 (BCID2) to the antimicrobial stewardship program (ASP) could improve outcomes in bloodstream infections (BSI) of patients with febrile neutropenia (FN). A pre- and post-quasi-experimental single-center study was conducted at a reference hospital in Peru. Three groups were considered: patients with BSI before ASP intervention (control group), patients with BSI after ASP intervention (group 1), and patients with BSI after ASP intervention plus BCID2 PCR Panel implementation (group 2). Overall, 93 patients were identified (32 control, 30 group 1, 31 group 2). The median time to effective therapy was significantly shorter in group 2 compared to group 1 and control group, respectively (3.75 vs. 10 h, p = 0.004; 3.75 vs. 19 h, p < 0.001). No significant differences in terms of relapse of bacteremia, in-hospital mortality (all cause), and 30-day-all-cause hospital readmission between the three study periods were found. The appropriateness of empirical antimicrobial use, adding or change, and the following de-escalation or discontinuation was significant when the two intervention periods were compared with the control group (p < 0.001). In addition to the lack of local studies documenting the microbiological profile of FN episodes, adding syndromic panels-based testing could allow for the consolidation of ASP strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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44. The effect of the efflux pump inhibitor Carbonyl Cyanide m-Chlorophenylhydrazone (CCCP) on the susceptibility to imipenem and cefepime in clinical strains of Acinetobacter baumannii

Author

Sanchez-Carbonel, Alejandra, primary, Mondragón, Belén, additional, López-Chegne, Nicolás, additional, Peña-Tuesta, Isaac, additional, Huayan-Dávila, Gladys, additional, Blitchtein, Dora, additional, Carrillo-Ng, Hugo, additional, Silva-Caso, Wilmer, additional, Aguilar-Luis, Miguel Angel, additional, and del Valle-Mendoza, Juana, additional

Published
2021
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45. Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics

Author

Pérez-Lazo, Giancarlo, primary, Silva-Caso, Wilmer, additional, del Valle-Mendoza, Juana, additional, Morales-Moreno, Adriana, additional, Ballena-López, José, additional, Soto-Febres, Fernando, additional, Martins-Luna, Johanna, additional, Carrillo-Ng, Hugo, additional, del Valle, Luís J., additional, Kym, Sungmin, additional, Aguilar-Luis, Miguel Angel, additional, Peña-Tuesta, Issac, additional, Tinco-Valdez, Carmen, additional, and Illescas, Luis Ricardo, additional

Published
2021
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46. Additional file 2 of Characterization of the gut microbiota in diabetes mellitus II patients with adequate and inadequate metabolic control

Author

Hamasaki-Matos, Angie Joyce, Cóndor-Marín, Katherine Marlene, Aquino-Ortega, Ronald, Carrillo-Ng, Hugo, Ugarte-Gil, Cesar, Silva-Caso, Wilmer, Aguilar-Luis, Miguel Angel, and del Valle-Mendoza, Juana

Subjects
digestive system
Abstract

Additional file2: Table S1. Primers and sequences used for the molecular identification of the gut microbiota. Adapted from Murri et al [19]. Table S2. Genus of bacteria found by group of diabetic patients.

Published
2021
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47. Additional file 1 of Community acquired Acinetobacter baumannii in pediatric patients under 1 year old with a clinical diagnosis of whooping cough in Lima, Peru

Author

Pe��a-Tuesta, Isaac, del Valle-Vargas, Cristina, Petrozzi-Helasvuo, Veronica, Aguilar-Luis, Miguel Angel, Carrillo-Ng, Hugo, Silva-Caso, Wilmer, and del Valle-Mendoza, Juana

Subjects
polycyclic compounds, bacteria, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

Additional file 1: Table S1. Primers and probe for the detection of the OXA-51 gene of Acinetobacter baumannii.

Published
2021
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48. Additional file 1 of Genotype-specific prevalence of human papillomavirus infection in asymptomatic Peruvian women: a community-based study

Author

Valle-Mendoza, Juana Del, Becerra-Goicochea, Lorena, Aguilar-Luis, Miguel Angel, Pinillos-Vilca, Luis, Carrillo-Ng, Hugo, Silva-Caso, Wilmer, Palomares-Reyes, Carlos, Andre-Alonso Taco-Masias, Aquino-Ortega, Ronald, Tinco-Valdez, Carmen, Yordi Tarazona-Castro, Cynthia-Wendy Sarmiento-Ramirez, and Valle, Luis J. Del

Subjects
virus diseases
Abstract

Additional file 1: Table S1. Human papillomavirus types and oncogenic potential. Table S2. Most frequent HPV types identified in the population studied.

Published
2021
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49. Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru

Author

Del Valle-Mendoza, Juana, del Valle-Vargas, Cristina, Aquino-Ortega, Ronald, Del Valle, Luis J, Cieza-Mora, Erico, Silva-Caso, Wilmer, Bazán-Mayra, Jorge, Zavaleta-Gavidia, Victor, Aguilar-Luis, Miguel Angel, Cornejo-Pacherres, Hernán, Martins-Luna, Johanna, and Cornejo-Tapia, Angela

Subjects
Whooping cough, Peru, Bordetella pertussis, Real-time polymerase chain reaction
Abstract

Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, besides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru. Background and Objectives: Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, be-sides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru. Materials and Methods: The population of this cross-sectional study were children under 5 years old hospitalized as presumptive cases of pertussis during December 2017 to December 2018. The nasopharyngeal samples were analyzed by real-time PCR for the detection of B. pertussis. Results: B. pertussis was identified as PCR + in 42.3% of our sample (33/78). The clinical presentation that was observed most frequently includes paroxysmal coughing (97%), difficulty breathing (69.7%), cyanosis (72.7%) and post-tussive em-esis (60.6%). Additionally, pneumonia was the most observed complication (33.3%). Four of the patients with PCR+ for B. pertussis presented only lymphocytosis, five only leukocytosis, two patients with decreased leukocytosis and lymphocytes and only one patient with leukopenia and relative lymphocytosis. There was a percentage of 84.8% of unvaccinated children in the PCR+ group. Finally, the mother was the most frequent symptom carrier (18.2%). Conclusion: In conclusion, in the studied population there is a high rate of PCR+ cases for B. pertussis. Laboratory values may show leukopenia or lymphopenia in patients with pertussis. It is necessary to use appropriate laboratory diagnostic tests in all infants with respiratory symptoms for B. pertussis. Since, the clinical diagnosis overestimates the diagnosis of pertussis. Revisión por pares

Published
2021

50. Screening and Assessment of Antimicrobial Susceptibility of Periodontopathic Bacteria in Peruvian Patients with Periodontitis: A Pilot Study

Author

Aguilar-Luis, Miguel Angel, Casas Apayco, Leslie, Tinco Valdez, Carmen, De Lama-Odría, María del Carmen Weilg, Claudia, Mazulis, Fernando, Silva-Caso, Wilmer Gianfranco, and Del Valle-Mendoza, Juana Mercedes

Subjects
Prevalent worldwid, Antimicrobial Susceptibility, Screening, Periodontopathic Bacteria, Periodontitis
Abstract

Background. Severe periodontal disease is highly prevalent worldwide, affecting 20% of the population between the ages of 35 and 44 years. The etiological epidemiology in Peru is scarce, even though some studies describe a prevalence of 48.5% of periodontal disease in the general population. Periodontitis is one of the most prevalent oral diseases associated with site-specific changes in the oral microbiota and it has been associated with a socioeconomic state. This study aimed to determine the etiology and resistance profile of bacteria identified in a group of Peruvian patients with periodontal disease. Methods. Six subgingival plaque samples were collected from eight patients with severe periodontitis. Bacterial identification was carried out by an initial culture, PCR amplification, and subsequently DNA sequencing. We evaluated the antibiotic susceptibility by the disk diffusion method. Results. Variable diversity in oral microbiota was identified in each one of the eight patients. The bacterial genus most frequently found was Streptococcus spp. (15/48, 31.3%) followed by Rothia spp. (11/48, 22.9%), Actinomyces spp. (9/48, 18.8%), and Eikenella spp. (4/48, 8.3%). The most common species found was Rothia dentocariosa (8/48, 16.7%). The antimicrobial susceptibility assay varied according to the species tested; however, among all the isolates evaluated, Actinomyces naeslundii was resistant to penicillin and tetracycline; Eikenella corrodens was resistant to dicloxacillin; and Rothia dentocariosa was resistant to amoxicillin + clavulanic acid and metronidazole but also susceptible to trimethoprim-sulfamethoxazole. Conclusions. The most prevalent periodontal bacterium found in this study was Rothia dentocariosa. Specific antimicrobial therapy is required to improve the treatment outcomes of patients with periodontal disease and avoid antibiotic resistance.

Published
2021

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