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Despite routine detection of coseismic acoustic‐gravity waves (AGWs) in Global Navigation Satellite System (GNSS) total electron content (TEC) observations, models of the earthquake‐atmosphere‐ionosphere dynamics, essential for validating data‐driven studies, remain limited. We present the results of three‐dimensional numerical simulations encompassing the entire coupling from Earth's interior to the ionosphere during the Mw ${M}_{w}$ 7.8 2016 Kaikoura earthquake. Incorporating the impact of data/model uncertainties in estimating the ionospheric state, the results show a good agreement between observed and simulated slant TEC (sTEC) signals, assessed through a set of metrics. The signals exhibit intricate waveforms, resulting from the integrated nature of TEC and phase cancellation effects, emphasizing the significance of direct signal comparisons along realistic line‐of‐sight paths. By comparing simulation results initialized with kinematic and dynamic source models, the study demonstrates the quantifiable sensitivity of sTEC to AGW source specifications, pointing to their utility in the analysis of coupled dynamics. Plain Language Summary: Earthquakes launch acoustic‐gravity waves (AGWs) into the atmosphere, spanning periods from seconds to minutes, that can reach the ionosphere at ∼ ${\sim} $100–400 km altitude. The majority of AGW detections in the ionosphere are performed with the use of GNSS signals collected with ground‐based receivers that nowadays comprehensively cover seismically active regions. However, the modeling of earthquake‐atmosphere‐ionosphere processes together, essential for validating and supporting data‐driven studies, remains rare. We present the outcomes of three‐dimensional numerical modeling of interconnected processes, spanning from Earth's interior to the ionosphere. We conducted a case study focused on the 2016 Mw ${M}_{w}$ 7.8 earthquake in New Zealand, renowned for its complexity and comprehensive observations of coseismic AGWs recorded with GNSS signals. Our results demonstrate a high level of accuracy of simulated GNSS signals, also revealing the high sensitivity to the chosen earthquake model and the complexity of resulting ionospheric signals, highlighting the necessity of attributing realistic geometries of GNSS TEC observations. The findings highlight the potential for using GNSS signals to investigate coseismic AGWs to infer characteristics of earthquakes. Key Points: Acoustic‐gravity wave‐driven slant total electron content (sTEC) signals are analyzed in terms of amplitude, waveform, and onset timeIntricate sTEC signal waveforms result from ionospheric fluctuations measured along lines‐of‐sight between satellites and receiversHigh sensitivity of sTEC signals to acoustic‐gravity wave source specification provides additional basis for earthquake characterization [ABSTRACT FROM AUTHOR]

The etiology of PMS has not yet been defined, although there are several theories among which it is reported that there is an increase in prolactine levels involved in it. The purpose of this study was to evaluate a dopamine receptor agonist (lisuride maleate), in the treatment of PMS. 35 patients between 19 and 35 years old were recruited in a prospective study design, with diagnosis of PMS and no other gynecological disorder ruled out clinical and ultrasonographic examination, women with no previous treatment and with no use of hormonal agents, these patients were treated for three months with lisuride maleate, 0.3 mg-day in a three dosage scheme per day, the following symptoms were evaluated: headaches, mastalgia, bloating, edema of lower extremities and myalgia in legs, as well as hormonal parameters before and after treatment with estrogens, progesterone, prolactine, luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone, which were prescribed in the luteal phase (day 21). Results obtained were: reduction of all symptoms scores versus pretreatment: Headache from 85.7 to 20%, mastalgia from 91.4 to 25%, bloating from 74.2 to 40%, edema in lower extremities from 85.7 to 30%, myalgia in legs, from 61 to 34%. The hormonal profile only showed changes in FSH, since the basal pretreatment level was found in 18.6 and the post-treatment value was 13.86, progesterone from 2.7 to 4.6 and prolactine from 7.74 to 6.82. We conclude the lisuride maleate is a good option to the PMS treatment, since a significative reduction of symptoms are induced and it is well tolerated.