2,165 results on '"Aguilar, A. C."'
Search Results
2. The glue that binds us all -- Latin America and the Electron-Ion Collider
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Aguilar, A. C., Bashir, A., Cobos-Martínez, J. J., Courtoy, A., El-Bennich, B., de Florian, D., Frederico, T., Gonçalves, V. P., Hentschinski, M., Hernández-Pinto, R. J., Krein, G., Machado, M. V. T., de Melo, J. P. B. C., de Paula, W., Sassot, R., Serna, F. E., Albino, L., Borsa, I., Cieri, L., Mazzitelli, J., Miramontes, Á., Raya, K., Salazar, F., Sborlini, G., and Zurita, P.
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Nuclear Experiment ,High Energy Physics - Experiment ,High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
The Electron-Ion Collider, a next generation electron-hadron and electron-nuclei scattering facility, will be built at Brookhaven National Laboratory. The wealth of new data will shape research in hadron physics, from nonperturbative QCD techniques to perturbative QCD improvements and global QCD analyses, for the decades to come. With the present proposal, Latin America based physicists, whose expertise lies on the theory and phenomenology side, make the case for the past and future efforts of a growing community, working hand-in-hand towards developing theoretical tools and predictions to analyze, interpret and optimize the results that will be obtained at the EIC, unveiling the role of the glue that binds us all. This effort is along the lines of various initiatives taken in the U.S., and supported by colleagues worldwide, such as the ones by the EIC User Group which were highlighted during the Snowmass Process and the Particle Physics Project Prioritization Panel (P5)., Comment: White Paper contribution to the Latin American Strategy Forum for Research Infrastructure (III LASF4RI
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- 2024
3. Infrared properties of the quark-gluon vertex in general kinematics
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Aguilar, A. C., Ferreira, M. N., Linhares, G. T., Oliveira, B. M., and Papavassiliou, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory ,Nuclear Theory - Abstract
In the present work we determine the eight form factors of the transversely-projected quark-gluon vertex in general kinematics, in the context of Landau-gauge QCD with two degenerate light dynamical quarks. The study is based on the set of Schwinger-Dyson equations that govern the vertex form factors, derived within the formalism of the three-particle-irreducible (3PI) effective action. The analysis is performed by employing lattice data for the main ingredients, such as gluon and quark propagators, and three-gluon vertex. The numerical treatment is simplified by decoupling the system of integral equations: the classical form factor is determined from a single non-linear equation involving only itself, while the remaining ones are subsequently computed through simple integrations. The form factors are obtained for arbitrary values of space-like momenta, and their angular dependence is examined in detail. A clear hierarchy is established at the level of the corresponding dimensionless effective couplings, in agreement with results of earlier studies. Furthermore, the classical form factor is found to be in excellent agreement with recent unquenched lattice data in the soft-gluon configuration, while the two non-classical dressings depart substantially from the lattice results. Finally, the accurate implementation of multiplicative renormalizability is confirmed, and the transition from Minkoswski to Euclidean space is elucidated., Comment: 39 pages, 15 figures
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- 2024
4. Nonperturbative four-gluon vertex in soft kinematics
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Aguilar, A. C., De Soto, F., Ferreira, M. N., Papavassiliou, J., Pinto-Gómez, F., Rodríguez-Quintero, J., and Santos, L. R.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory ,Nuclear Theory - Abstract
We present a nonperturbative study of the form factor associated with the projection of the full four-gluon vertex on its classical tensor, for a set of kinematics with one vanishing and three arbitrary external momenta. The treatment is based on the Schwinger-Dyson equation governing this vertex, and a large-volume lattice simulation, involving ten thousand gauge field configurations. The key hypothesis employed in both approaches is the ``planar degeneracy'', which classifies diverse configurations by means of a single variable, thus enabling their meaningful ``averaging''. The results of both approaches show notable agreement, revealing a considerable suppression of the averaged form factor in the infrared. The deviations from the exact planar degeneracy are discussed in detail, and a supplementary variable is used to achieve a more accurate description. The effective charge defined through this special form factor is computed within both approaches, and the results obtained are in excellent agreement., Comment: 8 pages, 7 figures
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- 2024
5. Lattice determination of the Batalin-Vilkovisky function and the strong running interaction
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Aguilar, A. C., Brito, N., Ferreira, M. N., Papavassiliou, J., Oliveira, O., and Silva, P. J.
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,High Energy Physics - Theory ,Nuclear Theory - Abstract
The Batalin-Vilkovisky function is a central component in the modern formulation of the background field method and the physical applications derived from it. In the present work we report on novel lattice results for this particular quantity, obtained by capitalizing on its equality with the Kugo-Ojima function in the Landau gauge. The results of the lattice simulation are in very good agreement with the predictions derived from a continuum analysis based on the corresponding Schwinger-Dyson equations. In addition, we show that an important relation connecting this function with the ghost propagator is fulfilled rather accurately. With the aid of these results, we carry out the first completely lattice-based determination of the process-independent strong running interaction, employed in a variety of phenomenological studies., Comment: 8 pages, 6 figures
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- 2024
6. Four-gluon vertex in collinear kinematics
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Aguilar, A. C., Ferreira, M. N., Papavassiliou, J., and Santos, L. R.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory ,Nuclear Theory - Abstract
To date, the four-gluon vertex is the least explored component of the QCD Lagrangian, mainly due to the vast proliferation of Lorentz and color structures required for its description. In this work we present a nonperturbative study of this vertex, based on the one-loop dressed Schwinger-Dyson equation obtained from the 4PI effective action. A vast simplification is brought about by resorting to ``collinear'' kinematics, where all momenta are parallel to each other, and by appealing to the charge conjugation symmetry in order to eliminate certain color structures. Out of the fifteen form factors that comprise the transversely-projected version of this vertex, two are singled out and studied in detail; the one associated with the classical tensorial structure is moderately suppressed in the infrared regime, while the other diverges logarithmically at the origin. Quite interestingly, both form factors display the property known as ``planar degeneracy'' at a rather high level of accuracy. With these results we construct an effective charge that quantifies the strength of the four-gluon interaction, and compare it with other vertex-derived charges from the gauge sector of QCD., Comment: 45 pages, 11 figures
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- 2024
7. Computation of the Kugo-Ojima function from lattice simulations
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Brito, Nuno, Oliveira, Orlando, Silva, Paulo J., Papavassiliou, Joannis, Ferreira, Mauricio N., and Aguilar, Arlene C.
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High Energy Physics - Lattice - Abstract
In addition to its connection with a standard confinement criterion, the Kugo-Ojima function constitutes an indispensable component in a multitude of applications in the gauge sector of QCD. In the present work we report on preliminary results of an ongoing large-volume lattice simulation of this special function. In particular, the volume-dependence of the data is studied in detail, and a comparison with results obtained from Schwinger-Dyson equations is carried out., Comment: 7 pages, 5 figures, Lattice 2023 proceedings
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- 2023
8. Entomological survey and 'Leishmania 'Leishmania) mexicana' prevalence in sand fly species during an outbreak of cutaneous leishmaniasis in Quintana Roo State, Mexico
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Caneda-Guzman, Isabel C, de Oca-Aguilar, Ana C Montes, Miranda-Caballero, Carlos I, Grostieta, Estefania, Correa-Morales, Fabian, Romero-Perez, Raquel, Romero-Contreras, Francisco E, Rodriguez-Atanacio, Jose A, Ruiz-Tovar, Karina, Huerta, Heron, Mis-Avila, Pedro C, Quintanilla-Cedillo, Marco R, Lammoglia-Villagomez, Miguel A, Blum-Dominguez, Selene, Tamay-Segovia, Paulino, Rojas-Ronquillo, Rebeca, Sanchez-Montes, Sokani, and Becker, Ingeborg
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- 2023
9. Variations in irradiation energy and rose bengal concentration for photodynamic antimicrobial therapy of fungal keratitis isolates
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Arboleda, Alejandro, Durkee, Heather, Miller, Darlene, Aguilar, Mariela C., Alawa, Karam, Relhan, Nidhi, Amescua, Guillermo, and Parel, Jean-Marie
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- 2024
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10. PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling
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Chen, Tianlai, Dumas, Madeleine, Watson, Rio, Vincoff, Sophia, Peng, Christina, Zhao, Lin, Hong, Lauren, Pertsemlidis, Sarah, Shaepers-Cheu, Mayumi, Wang, Tian Zi, Srijay, Divya, Monticello, Connor, Vure, Pranay, Pulugurta, Rishab, Kholina, Kseniia, Goel, Shrey, DeLisa, Matthew P., Truant, Ray, Aguilar, Hector C., and Chatterjee, Pranam
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Quantitative Biology - Biomolecules - Abstract
Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity strategies, such as PROTACs and molecular glues, have thus gained attention as pharmacological alternatives, but still require small molecule docking at binding pockets for targeted protein degradation. The computational design of protein-based binders presents unique opportunities to access "undruggable" targets, but have often relied on stable 3D structures or structure-influenced latent spaces for effective binder generation. In this work, we introduce PepMLM, a target sequence-conditioned generator of de novo linear peptide binders. By employing a novel span masking strategy that uniquely positions cognate peptide sequences at the C-terminus of target protein sequences, PepMLM fine-tunes the state-of-the-art ESM-2 pLM to fully reconstruct the binder region, achieving low perplexities matching or improving upon validated peptide-protein sequence pairs. After successful in silico benchmarking with AlphaFold-Multimer, outperforming RFDiffusion on structured targets, we experimentally verify PepMLM's efficacy via fusion of model-derived peptides to E3 ubiquitin ligase domains, demonstrating endogenous degradation of emergent viral phosphoproteins and Huntington's disease-driving proteins. In total, PepMLM enables the generative design of candidate binders to any target protein, without the requirement of target structure, empowering downstream therapeutic applications.
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- 2023
11. Magnetic structure and phase diagram of the Heisenberg-Ising spin chain antiferromagnetic PbCo$_{2}$V$_{2}$O$_{8}$
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Puzniak, K., Aguilar-Maldonado, C., Feyerherm, R., Prokeš, K., Islam, A. T. M. N., Skourski, Y., Keller, L., and Lake, B.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The effective spin-1/2 antiferromagnetic Heisenberg-Ising chain materials, ACo$_2$V$_2$O$_8$, A = Sr, Ba, are a rich source of exotic fundamental phenomena and have been investigated for their model magnetic properties both in zero and non-zero magnetic fields. Here we investigate a new member of the family, namely PbCo$_2$V$_2$O$_8$. We synthesize powder and single crystal samples of PbCo$_2$V$_2$O$_8$ and determine its magnetic structure using neutron diffraction. Furthermore, the magnetic field/temperature phase diagrams for magnetic field applied along the c, a, and [110] crystallographic directions in the tetragonal unit cell are determined via magnetization and heat capacity measurements. A complex series of phases and quantum phase transitions are discovered that depend strongly on both the magnitude and direction of the field. Our results show that \pcvo is an effective spin-1/2 antiferromagnetic Heisenberg-Ising chain with properties that are in general comparable to those of SrCo$_2$V$_2$O$_8$ and BaCo$_2$V$_2$O$_8$. One interesting departure from the results of these related compounds, is however, the discovery of a new field-induced phase for the field direction $H\|$[110] which has not been previously observed.
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- 2023
12. Marafalfa grass (Pennisetum purpureum Schum) and mucuna (Stizolobium pruriens L. Medik) silage in a semi-confined sheep system in southeastern Mexico
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Chiquini-Medina, Ricardo A., Cardenas-Lopez, Roberto A., Palma-Cancino, David J., and Castillo-Aguilar, Crescencio C.
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- 2024
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13. Schwinger displacement of the quark-gluon vertex
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Aguilar, A. C., Ferreira, M . N., Ibañez, D., and Papavassiliou, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory ,Nuclear Theory - Abstract
The action of the Schwinger mechanism in pure Yang-Mills theories endows gluons with an effective mass, and, at the same time, induces a measurable displacement to the Ward identity satisfied by the three-gluon vertex. In the present work we turn to Quantum Chromodynamics with two light quark flavors, and explore the appearance of this characteristic displacement at the level of the quark-gluon vertex. When the Schwinger mechanism is activated, this vertex acquires massless poles, whose momentum-dependent residues are determined by a set of coupled integral equations. The main effect of these residues is to displace the Ward identity obeyed by the pole-free part of the vertex, causing modifications to its form factors, and especially the one associated with the tree-level tensor. The comparison between the available lattice data for this form factor and the Ward identity prediction reveals a marked deviation, which is completely compatible with the theoretical expectation for the attendant residue. This analysis corroborates further the self-consistency of this mass-generating scenario in the general context of real-world strong interactions., Comment: 41 pages, 12 figures
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- 2023
14. Schwinger poles of the three-gluon vertex: symmetry and dynamics
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Aguilar, A. C., Ferreira, M. N., Oliveira, B. M., Papavassiliou, J., and Santos, L. R.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory ,Nuclear Theory - Abstract
The implementation of the Schwinger mechanism endows gluons with a nonperturbative mass through the formation of special massless poles in the fundamental QCD vertices; due to their longitudinal character, these poles do not cause divergences in on-shell amplitudes, but induce detectable effects in the Green's functions of the theory. Particularly important in this theoretical setup is the three-gluon vertex, whose pole content extends beyond the minimal structure required for the generation of a gluon mass. In the present work we analyze these additional pole patterns by means of two distinct, but ultimately equivalent, methods: the Slavnov-Taylor identity satisfied by the three-gluon vertex, and the nonlinear Schwinger-Dyson equation that governs the dynamical evolution of this vertex. Our analysis reveals that the Slavnov-Taylor identity imposes strict model-independent constraints on the associated residues, preventing them from vanishing. Approximate versions of these constraints are subsequently recovered from the Schwinger-Dyson equation, once the elements responsible for the activation of the Schwinger mechanism have been duly incorporated. The excellent coincidence between the two approaches exposes a profound connection between symmetry and dynamics, and serves as a nontrivial self-consistency test of this particular mass generating scenario., Comment: 39 pages, 10 figures
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- 2023
15. Correction to: Effective transport properties for the pyridine-granular activated carbon adsorption system
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Baz-Rodríguez, S. A., Ocampo-Pérez, R., Ruelas-Leyva, J. P., and Aguilar-Madera, C. G.
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- 2024
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16. Planar degeneracy of the three-gluon vertex
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Aguilar, A. C., Ferreira, M. N., Papavassiliou, J., and Santos, L. R.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,Nuclear Theory - Abstract
We present a detailed exploration of certain outstanding features of the transversely-projected three-gluon vertex, using the corresponding Schwinger-Dyson equation in conjunction with key results obtained from quenched lattice simulations. The main goal of this study is the scrutiny of the approximate property denominated ``planar degeneracy'', unveiled when the Bose symmetry of the vertex is properly exploited. The planar degeneracy leads to a particularly simple parametrization of the vertex, reducing its kinematic dependence to essentially a single variable. Our analysis, carried out in the absence of dynamical quarks, reveals that the planar degeneracy is particularly accurate for the description of the form factor associated with the classical tensor, for a wide array of arbitrary kinematic configurations. Instead, the remaining three form factors display considerable violations of this property. In addition, and in close connection with the previous point, we demonstrate the numerical dominance of the classical form factor over all others, except in the vicinity of the soft-gluon kinematics. The final upshot of these considerations is the emergence of a very compact description for the three-gluon vertex in general kinematics, which may simplify significantly nonperturbative applications involving this vertex., Comment: 39 pages, 10 figures
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- 2023
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17. Patterns of gauge symmetry in the background field method
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Aguilar, A. C., Ferreira, M. N., Ibañez, D., Oliveira, B. M., and Papavassiliou, J.
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High Energy Physics - Theory ,High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
The correlation functions of Yang-Mills theories formulated in the background field method satisfy linear Slavnov-Taylor identities, which are naive generalizations of simple tree level relations, with no deformations originating from the ghost sector of the theory. In recent years, a stronger version of these identities has been found to hold at the level of the background gluon self-energy, whose transversality is enforced separately for each special block of diagrams contributing to the gluon Schwinger-Dyson equation. In the present work we demonstrate by means of explicit calculations that the same distinct realization of the Slavnov-Taylor identity persists in the case of the background three-gluon vertex. The analysis is carried out at the level of the exact Schwinger-Dyson equation for this vertex, with no truncations or simplifying assumptions. The demonstration entails the contraction of individual vertex diagrams by the relevant momentum, which activates Slavnov-Taylor identities of vertices and multi-particle kernels nested inside these graphs; the final result emerges by virtue of a multitude of extensive cancellations, without the need of performing explicit integrations. In addition, we point out that background Ward identities amount to replacing derivatives of propagators by zero-momentum background-gluon insertions, in exact analogy to standard properties of Abelian gauge theories. Finally, certain potential applications of these results are briefly discussed., Comment: 35 pages, 9 figures
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- 2022
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18. Schwinger mechanism for gluons from lattice QCD
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Aguilar, A. C., De Soto, F., Ferreira, M. N., Papavassiliou, J., Pinto-Gómez, F., Roberts, C. D., and Rodríguez-Quintero, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,High Energy Physics - Lattice ,Nuclear Experiment ,Nuclear Theory - Abstract
Continuum and lattice analyses have revealed the existence of a mass-scale in the gluon two-point Schwinger function. It has long been conjectured that this expresses the action of a Schwinger mechanism for gauge boson mass generation in quantum chromodynamics (QCD). For such to be true, it is necessary and sufficient that a dynamically-generated, massless, colour-carrying, scalar gluon+gluon correlation emerge as a feature of the dressed three-gluon vertex. Working with results on elementary Schwinger functions obtained via the numerical simulation of lattice-regularised QCD, we establish with an extremely high level of confidence that just such a feature appears; hence, confirm the conjectured origin of the gluon mass scale., Comment: 8 pages, 8 figures
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- 2022
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19. Schwinger-Dyson truncations in the all-soft limit: a case study
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Aguilar, A. C., Ferreira, M. N., Oliveira, B. M., and Papavassiliou, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory ,Nuclear Theory - Abstract
We study a special Schwinger-Dyson equation in the context of a pure SU(3) Yang-Mills theory, formulated in the background field method. Specifically, we consider the corresponding equation for the vertex that governs the interaction of two background gluons with a ghost-antighost pair. By virtue of the background gauge invariance, this vertex satisfies a naive Slavnov-Taylor identity, which is not deformed by the ghost sector of the theory. In the all-soft limit, where all momenta vanish, the form of this vertex may be obtained exactly from the corresponding Ward identity. This special result is subsequently reproduced at the level of the Schwinger-Dyson equation, by making extensive use of Taylor's theorem and exploiting a plethora of key relations, particular to the background field method. This information permits the determination of the error associated with two distinct truncation schemes, where the potential advantage from employing lattice data for the ghost dressing function is quantitatively assessed., Comment: 29 pages, 9 figures
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- 2022
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20. Photodynamic antimicrobial therapy with Erythrosin B, Eosin Y, and Rose Bengal for the inhibition of fungal keratitis isolates: An in vitro study
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Chou, Brandon, Krishna, Katherine, Durkee, Heather, Echeverri Tribin, Felipe, Ahmed, Anam, Lai, James, Aguilar, Mariela C., Ferreira, Braulio C.L.B., Leblanc, Roger M., Flynn, Harry W., Jr, Amescua, Guillermo, Parel, Jean-Marie, and Miller, Darlene
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- 2025
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21. Generation of thiyl radicals in a spatiotemporal controlled manner by light: Applied for the cis to trans isomerization of unsaturated fatty acids/phospholipids
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Roy, Biswajit, Kojima, Ryota, Shah, Obaed, Shieh, Meg, Das, Eshani, Ezzatpour, Shahrzad, Sato, Emiko, Hirata, Yusuke, Lindahl, Stephen, Matsuzawa, Atsushi, Aguilar, Hector C., and Xian, Ming
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- 2025
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22. Glutamine metabolism is essential for coronavirus replication in host cells and in mice
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Greene, Kai Su, Choi, Annette, Yang, Nianhui, Chen, Matthew, Li, Ruizhi, Qiu, Yijian, Ezzatpour, Shahrzad, Rojas, Katherine S., Shen, Jonathan, Wilson, Kristin F., Katt, William P., Aguilar, Hector C., Lukey, Michael J., Whittaker, Gary R., and Cerione, Richard A.
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- 2025
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23. Effect of concentration on singlet oxygen generation from xanthene-based photosensitizers
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Ferreira, Braulio C.L.B., Durkee, Heather A., Aston, Lillian, Gonzalez, Leonardo, Peterson, Jeffrey, Ahmed, Anam, Navia, Juan Carlos, Echeverri Tribin, Felipe, Aguilar, Mariela C., Gonzalez, Alex, Ruggeri, Marco, Manns, Fabrice, Amescua, Guillermo, Parel, Jean-Marie, and Leblanc, Roger M.
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- 2025
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24. Immunogenetics associated with severe coccidioidomycosis
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Hsu, Amy P, Korzeniowska, Agnieszka, Aguilar, Cynthia C, Gu, Jingwen, Karlins, Eric, Oler, Andrew J, Chen, Gang, Reynoso, Glennys V, Davis, Joie, Chaput, Alexandria, Peng, Tao, Sun, Ling, Lack, Justin B, Bays, Derek J, Stewart, Ethan R, Waldman, Sarah E, Powell, Daniel A, Donovan, Fariba M, Desai, Jigar V, Pouladi, Nima, Priel, Debra A Long, Yamanaka, Daisuke, Rosenzweig, Sergio D, Niemela, Julie E, Stoddard, Jennifer, Freeman, Alexandra F, Zerbe, Christa S, Kuhns, Douglas B, Lussier, Yves A, Olivier, Kenneth N, Boucher, Richard C, Hickman, Heather D, Frelinger, Jeffrey, Fierer, Joshua, Shubitz, Lisa F, Leto, Thomas L, Thompson, George R, Galgiani, John N, Lionakis, Michail S, and Holland, Steven M
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Rare Diseases ,Prevention ,Vaccine Related ,Biodefense ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Good Health and Well Being ,Humans ,Tumor Necrosis Factor-alpha ,Hydrogen Peroxide ,Coccidioidomycosis ,Coccidioides ,beta-Glucans ,Fungal infections ,Genetics ,Infectious disease ,Innate immunity ,Population genetics - Abstract
Disseminated coccidioidomycosis (DCM) is caused by Coccidioides, pathogenic fungi endemic to the southwestern United States and Mexico. Illness occurs in approximately 30% of those infected, less than 1% of whom develop disseminated disease. To address why some individuals allow dissemination, we enrolled patients with DCM and performed whole-exome sequencing. In an exploratory set of 67 patients with DCM, 2 had haploinsufficient STAT3 mutations, and defects in β-glucan sensing and response were seen in 34 of 67 cases. Damaging CLEC7A and PLCG2 variants were associated with impaired production of β-glucan-stimulated TNF-α from PBMCs compared with healthy controls. Using ancestry-matched controls, damaging CLEC7A and PLCG2 variants were overrepresented in DCM, including CLEC7A Y238* and PLCG2 R268W. A validation cohort of 111 patients with DCM confirmed the PLCG2 R268W, CLEC7A I223S, and CLEC7A Y238* variants. Stimulation with a DECTIN-1 agonist induced DUOX1/DUOXA1-derived hydrogen peroxide [H2O2] in transfected cells. Heterozygous DUOX1 or DUOXA1 variants that impaired H2O2 production were overrepresented in discovery and validation cohorts. Patients with DCM have impaired β-glucan sensing or response affecting TNF-α and H2O2 production. Impaired Coccidioides recognition and decreased cellular response are associated with disseminated coccidioidomycosis.
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- 2022
25. Discovery and Genomic Characterization of a Novel Henipavirus, Angavokely Virus, from Fruit Bats in Madagascar
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Madera, Sharline, Kistler, Amy, Ranaivoson, Hafaliana C, Ahyong, Vida, Andrianiaina, Angelo, Andry, Santino, Raharinosy, Vololoniaina, Randriambolamanantsoa, Tsiry H, Ravelomanantsoa, Ny Anjara Fifi, Tato, Cristina M, DeRisi, Joseph L, Aguilar, Hector C, Lacoste, Vincent, Dussart, Philippe, Heraud, Jean-Michel, and Brook, Cara E
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Medical Microbiology ,Biomedical and Clinical Sciences ,Biological Sciences ,Genetics ,Infectious Diseases ,Emerging Infectious Diseases ,Biodefense ,Rare Diseases ,Biotechnology ,2.2 Factors relating to the physical environment ,2.1 Biological and endogenous factors ,Infection ,Animals ,Chiroptera ,Genome ,Viral ,Glycoproteins ,Henipavirus ,Henipavirus Infections ,Humans ,Madagascar ,Nipah Virus ,Phylogeny ,Urine ,Zoonoses ,emerging zoonosis ,henipavirus ,novel virus ,Eidolon dupreanum ,bat-borne virus ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Virology ,Agricultural ,veterinary and food sciences ,Biological sciences ,Biomedical and clinical sciences - Abstract
The genus Henipavirus (family Paramyxoviridae) currently comprises seven viruses, four of which have demonstrated prior evidence of zoonotic capacity. These include the biosafety level 4 agents Hendra (HeV) and Nipah (NiV) viruses, which circulate naturally in pteropodid fruit bats. Here, we describe and characterize Angavokely virus (AngV), a divergent henipavirus identified in urine samples from wild, Madagascar fruit bats. We report the nearly complete 16,740-nucleotide genome of AngV, which encodes the six major henipavirus structural proteins (nucleocapsid, phosphoprotein, matrix, fusion, glycoprotein, and L polymerase). Within the phosphoprotein (P) gene, we identify an alternative start codon encoding the AngV C protein and a putative mRNA editing site where the insertion of one or two guanine residues encodes, respectively, additional V and W proteins. In other paramyxovirus systems, C, V, and W are accessory proteins involved in antagonism of host immune responses during infection. Phylogenetic analysis suggests that AngV is ancestral to all four previously described bat henipaviruses-HeV, NiV, Cedar virus (CedV), and Ghanaian bat virus (GhV)-but evolved more recently than rodent- and shrew-derived henipaviruses, Mojiang (MojV), Gamak (GAKV), and Daeryong (DARV) viruses. Predictive structure-based alignments suggest that AngV is unlikely to bind ephrin receptors, which mediate cell entry for all other known bat henipaviruses. Identification of the AngV receptor is needed to clarify the virus's potential host range. The presence of V and W proteins in the AngV genome suggest that the virus could be pathogenic following zoonotic spillover. IMPORTANCE Henipaviruses include highly pathogenic emerging zoonotic viruses, derived from bat, rodent, and shrew reservoirs. Bat-borne Hendra (HeV) and Nipah (NiV) are the most well-known henipaviruses, for which no effective antivirals or vaccines for humans have been described. Here, we report the discovery and characterization of a novel henipavirus, Angavokely virus (AngV), isolated from wild fruit bats in Madagascar. Genomic characterization of AngV reveals all major features associated with pathogenicity in other henipaviruses, suggesting that AngV could be pathogenic following spillover to human hosts. Our work suggests that AngV is an ancestral bat henipavirus that likely uses viral entry pathways distinct from those previously described for HeV and NiV. In Madagascar, bats are consumed as a source of human food, presenting opportunities for cross-species transmission. Characterization of novel henipaviruses and documentation of their pathogenic and zoonotic potential are essential to predicting and preventing the emergence of future zoonoses that cause pandemics.
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- 2022
26. Theory and phenomenology of the three-gluon vertex
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Papavassiliou, J., Aguilar, A. C., and Ferreira, M. N.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice - Abstract
The three-gluon vertex is a fundamental ingredient of the intricate QCD dynamics, being inextricably connected to key nonperturbative phenomena, such as the emergence of a mass scale in the gauge sector of the theory. In this presentation, we review the main theoretical properties of the three-gluon vertex in the Landau gauge, obtained from the fruitful synergy between functional methods and lattice simulations. We pay particular attention to the manifestation and origin of the infrared suppression of its main form factors and the associated zero crossing. In addition, we discuss certain characteristic phenomenological applications that require this special vertex as input., Comment: 8 pages, 9 figures. Invited talk presented by J.P. at the 19th International Conference on Hadron Spectroscopy and Structure (HADRON 2021), 26 July- 1 August 2021, Mexico City, Mexico
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- 2022
27. Protein UFMylation regulates early events during ribosomal DNA-damage response
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Panichnantakul, Pudchalaluck, Aguilar, Lisbeth C., Daynard, Evan, Guest, Mackenzie, Peters, Colten, Vogel, Jackie, and Oeffinger, Marlene
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- 2024
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28. Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection
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Biering, Scott B, Sarnik, Sylvia A, Wang, Eleanor, Zengel, James R, Leist, Sarah R, Schäfer, Alexandra, Sathyan, Varun, Hawkins, Padraig, Okuda, Kenichi, Tau, Cyrus, Jangid, Aditya R, Duffy, Connor V, Wei, Jin, Gilmore, Rodney C, Alfajaro, Mia Madel, Strine, Madison S, Nguyenla, Xammy, Van Dis, Erik, Catamura, Carmelle, Yamashiro, Livia H, Belk, Julia A, Begeman, Adam, Stark, Jessica C, Shon, D Judy, Fox, Douglas M, Ezzatpour, Shahrzad, Huang, Emily, Olegario, Nico, Rustagi, Arjun, Volmer, Allison S, Livraghi-Butrico, Alessandra, Wehri, Eddie, Behringer, Richard R, Cheon, Dong-Joo, Schaletzky, Julia, Aguilar, Hector C, Puschnik, Andreas S, Button, Brian, Pinsky, Benjamin A, Blish, Catherine A, Baric, Ralph S, O’Neal, Wanda K, Bertozzi, Carolyn R, Wilen, Craig B, Boucher, Richard C, Carette, Jan E, Stanley, Sarah A, Harris, Eva, Konermann, Silvana, and Hsu, Patrick D
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Acute Respiratory Distress Syndrome ,Clinical Research ,Infectious Diseases ,Pneumonia & Influenza ,Rare Diseases ,Biodefense ,Lung ,Vaccine Related ,Pneumonia ,Prevention ,Emerging Infectious Diseases ,Genetics ,2.2 Factors relating to the physical environment ,2.1 Biological and endogenous factors ,Aetiology ,Respiratory ,Infection ,Good Health and Well Being ,Animals ,COVID-19 ,Clustered Regularly Interspaced Short Palindromic Repeats ,Epigenesis ,Genetic ,Humans ,Mice ,Mucins ,SARS-CoV-2 ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2-host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2. We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a family of high molecular weight glycoproteins, as a prominent viral restriction network that inhibits SARS-CoV-2 infection in vitro and in murine models. These mucins also inhibit infection of diverse respiratory viruses. This functional landscape of SARS-CoV-2 host factors provides a physiologically relevant starting point for new host-directed therapeutics and highlights airway mucins as a host defense mechanism.
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- 2022
29. Exploring smoking-gun signals of the Schwinger mechanism in QCD
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Aguilar, A. C., Ferreira, M. N., and Papavassiliou, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
In QCD, the Schwinger mechanism endows the gluons with an effective mass through the dynamical formation of massless bound-state poles that are longitudinally coupled. The presence of these poles affects profoundly the infrared properties of the interaction vertices, inducing crucial modifications to their fundamental Ward identities. Within this general framework, we present a detailed derivation of the non-Abelian Ward identity obeyed by the pole-free part of the three-gluon vertex in the soft-gluon limit, and determine the smoking-gun displacement that the onset of the Schwinger mechanism produces to the standard result. Quite importantly, the quantity that describes this distinctive feature coincides formally with the bound-state wave function that controls the massless pole formation. Consequently, this signal may be computed in two independent ways: by solving an approximate version of the pertinent Bethe-Salpeter integral equation, or by appropriately combining the elements that enter in the aforementioned Ward identity. For the implementation of both methods we employ two- and three-point correlation functions obtained from recent lattice simulations, and a partial derivative of the ghost-gluon kernel, which is computed from the corresponding Schwinger-Dyson equation. Our analysis reveals an excellent coincidence between the results obtained through either method, providing a highly nontrivial self-consistency check for the entire approach. When compared to the null hypothesis, where the Schwinger mechanism is assumed to be inactive, the statistical significance of the resulting signal is estimated to be three standard deviations., Comment: 44 pages, 12 figures
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- 2021
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30. Characterization of the cellular lipid composition during SARS-CoV-2 infection
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Abdel-Megied, Ahmed M., Monreal, Isaac A., Zhao, Limian, Apffel, Alex, Aguilar, Hector C., and Jones, Jace W.
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- 2023
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31. Novel requirements for HAP2/GCS1-mediated gamete fusion in Tetrahymena
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Pinello, Jennifer F., Loidl, Josef, Seltzer, Ethan S., Cassidy-Hanley, Donna, Kolbin, Daniel, Abdelatif, Anhar, Rey, Félix A., An, Rocky, Newberger, Nicole J., Bisharyan, Yelena, Papoyan, Hayk, Byun, Haewon, Aguilar, Hector C., Lai, Alex L., Freed, Jack H., Maugel, Timothy, Cole, Eric S., and Clark, Theodore G.
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- 2024
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32. Ghost dynamics in the soft gluon limit
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Aguilar, A. C., Ambrósio, C. O., De Soto, F., Ferreira, M. N., Oliveira, B. M., Papavassiliou, J., and Rodríguez-Quintero, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We present a detailed study of the dynamics associated with the ghost sector of quenched QCD in the Landau gauge, where the relevant dynamical equations are supplemented with key inputs originating from large-volume lattice simulations. In particular, we solve the coupled system of Schwinger-Dyson equations that governs the evolution of the ghost dressing function and the ghost-gluon vertex, using as input for the gluon propagator lattice data that have been cured from volume and discretization artifacts. In addition, we explore the soft gluon limit of the same system, employing recent lattice data for the three-gluon vertex that enters in one of the diagrams defining the Schwinger-Dyson equation of the ghost-gluon vertex. The results obtained from the numerical treatment of these equations are in excellent agreement with lattice data for the ghost dressing function, once the latter have undergone the appropriate scale-setting and artifact elimination refinements. Moreover, the coincidence observed between the ghost-gluon vertex in general kinematics and in the soft gluon limit reveals an outstanding consistency of physical concepts and computational schemes., Comment: 34 pages, 12 figures
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- 2021
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33. SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
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Biering, Scott B, Gomes de Sousa, Francielle Tramontini, Tjang, Laurentia V, Pahmeier, Felix, Zhu, Chi, Ruan, Richard, Blanc, Sophie F, Patel, Trishna S, Worthington, Caroline M, Glasner, Dustin R, Castillo-Rojas, Bryan, Servellita, Venice, Lo, Nicholas TN, Wong, Marcus P, Warnes, Colin M, Sandoval, Daniel R, Clausen, Thomas Mandel, Santos, Yale A, Fox, Douglas M, Ortega, Victoria, Näär, Anders M, Baric, Ralph S, Stanley, Sarah A, Aguilar, Hector C, Esko, Jeffrey D, Chiu, Charles Y, Pak, John E, Beatty, P Robert, and Harris, Eva
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Biodefense ,Lung ,Infectious Diseases ,Prevention ,Vaccine Related ,Pneumonia ,Emerging Infectious Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Good Health and Well Being ,Humans ,SARS-CoV-2 ,Angiotensin-Converting Enzyme 2 ,Spike Glycoprotein ,Coronavirus ,COVID-19 ,Endothelial Cells ,Integrins ,Peptidyl-Dipeptidase A ,Transforming Growth Factor beta - Abstract
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of vascular leak are unclear. Here, we report that cell-intrinsic interactions between the Spike (S) glycoprotein of SARS-CoV-2 and epithelial/endothelial cells are sufficient to induce barrier dysfunction in vitro and vascular leak in vivo, independently of viral replication and the ACE2 receptor. We identify an S-triggered transcriptional response associated with extracellular matrix reorganization and TGF-β signaling. Using genetic knockouts and specific inhibitors, we demonstrate that glycosaminoglycans, integrins, and the TGF-β signaling axis are required for S-mediated barrier dysfunction. Notably, we show that SARS-CoV-2 infection caused leak in vivo, which was reduced by inhibiting integrins. Our findings offer mechanistic insight into SARS-CoV-2-triggered vascular leak, providing a starting point for development of therapies targeting COVID-19.
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- 2022
34. Effect of an altitudinal gradient on the morphology, molecular identification and distribution of Rhipicephalus linnaei in Veracruz, Mexico
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Aguilar-Meraz, Pamela, Moo-Llanes, David A., Sánchez-Montes, Sokani, Montes de Oca-Aguilar, Ana C., Romero-Salas, Dora, Cruz-Romero, Anabel, López-Hernández, Karla M., Bermúdez-Castillero, Sergio E., and Aguilar-Domínguez, Mariel
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- 2024
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35. Infrared facets of the three-gluon vertex
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Aguilar, A. C., De Soto, F., Ferreira, M. N., Papavassiliou, J., and Rodríguez-Quintero, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We present novel lattice results for the form factors of the quenched three-gluon vertex of QCD, in two special kinematic configurations that depend on a single momentum scale. We consider three form factors, two associated with a classical tensor structure and one without tree-level counterpart, exhibiting markedly different infrared behaviors. Specifically, while the former display the typical suppression driven by a negative logarithmic singularity at the origin, the latter saturates at a small negative constant. These exceptional features are analyzed within the Schwinger-Dyson framework, with the aid of special relations obtained from the Slavnov-Taylor identities of the theory. The emerging picture of the underlying dynamics is thoroughly corroborated by the lattice results, both qualitatively as well as quantitatively., Comment: 7 pages, 7 figures
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- 2021
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36. Gluon dynamics from an ordinary differential equation
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Aguilar, A. C., Ferreira, M. N., and Papavassiliou, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We present a novel method for computing the nonperturbative kinetic term of the gluon propagator from an exactly solvable ordinary differential equation, whose origin is the fundamental Slavnov-Taylor identity satisfied by the three-gluon vertex, evaluated in a special kinematic limit. The main ingredients comprising the solution are a well-known projection of the three-gluon vertex, simulated on the lattice, and a particular derivative of the ghost-gluon kernel, whose approximate form is derived from a standard Schwinger-Dyson equation. Crucially, the physical requirement of a pole-free answer determines completely the form of the initial condition, whose value is calculated from a specific integral containing the same ingredients as the solution itself. This outstanding feature fixes uniquely, at least in principle, the form of the kinetic term, once the ingredients of the differential equation have been accurately evaluated. Furthermore, in the case where the gluon propagator has been independently accessed from the lattice, this property leads to the unambiguous extraction of the momentum-dependent effective gluon mass. The practical implementation of this method is carried out in detail, and the required approximations and theoretical assumptions are duly highlighted. The systematic improvement of this approach through the detailed computation of one of its pivotal components is briefly outlined., Comment: 35 pages, 12 figures, 2 tables
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- 2020
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37. Novel sum rules for the three-point sector of QCD
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Aguilar, A. C., Ferreira, M. N., and Papavassiliou, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
For special kinematic configurations involving a single momentum scale, certain standard relations, originating from the Slavnov-Taylor identities of the theory, may be interpreted as ordinary differential equations for the ``kinetic term'' of the gluon propagator. The exact solutions of these equations exhibit poles at the origin, which are incompatible with the physical answer, known to diverge only logarithmically; their elimination hinges on the validity of two integral conditions that we denominate ``asymmetric'' and ``symmetric'' sum rules, depending on the kinematics employed in their derivation. The corresponding integrands contain components of the three-gluon vertex and the ghost-gluon kernel, whose dynamics are constrained when the sum rules are imposed. For the numerical treatment we single out the asymmetric sum rule, given that its support stems predominantly from low and intermediate energy regimes of the defining integral, which are physically more interesting. Adopting a combined approach based on Schwinger-Dyson equations and lattice simulations, we demonstrate how the sum rule clearly favors the suppression of an effective form factor entering in the definition of its kernel. The results of the present work offer an additional vantage point into the rich and complex structure of the three-point sector of QCD., Comment: 34 pages, 7 figures, 1 table
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- 2020
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38. Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes
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León-Mimila, P, Villamil-Ramírez, H, Li, XS, Shih, DM, Hui, ST, Ocampo-Medina, E, López-Contreras, B, Morán-Ramos, S, Olivares-Arevalo, M, Grandini-Rosales, P, Macías-Kauffer, L, González-González, I, Hernández-Pando, R, Gómez-Pérez, F, Campos-Pérez, F, Aguilar-Salinas, C, Larrieta-Carrasco, E, Villarreal-Molina, T, Wang, Z, Lusis, AJ, Hazen, SL, Huertas-Vazquez, A, and Canizales-Quinteros, S
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Digestive Diseases ,Hepatitis ,Chronic Liver Disease and Cirrhosis ,Diabetes ,Liver Disease ,Clinical Research ,Nutrition ,Obesity ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Adult ,Betaine ,Bile Acids and Salts ,Biomarkers ,Biopsy ,Choline ,Diabetes Mellitus ,Type 2 ,Female ,Humans ,Insulin Resistance ,Liver ,Male ,Methylamines ,Mexican Americans ,Middle Aged ,Non-alcoholic Fatty Liver Disease ,Non-alcoholic fatty liver disease ,TMAO ,Type 2 diabetes ,Clinical Sciences ,Endocrinology & Metabolism ,Clinical sciences - Abstract
AimsTrimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance. However, the relationships among these metabolites, insulin resistance and NAFLD have not been thoroughly investigated. Moreover, it has recently been suggested that TMAO could play a role in NAFLD by altering bile acid metabolism. We examined the association between circulating TMAO, choline and betaine levels and NAFLD in obese subjects.MethodsSerum TMAO, choline, betaine and bile acid levels were measured in 357 Mexican obese patients with different grades of NAFLD as determined by liver histology. Associations of NAFLD with TMAO, choline and betaine levels were tested. Moreover, association of TMAO levels with non-alcoholic steatohepatitis (NASH) was tested separately in patients with and without T2D.ResultsTMAO and choline levels were significantly associated with NAFLD histologic features and NASH risk. While increased serum TMAO levels were significantly associated with NASH in patients with T2D, in non-T2D subjects this association lost significance after adjusting for sex, BMI and HOMA2-IR. Moreover, circulating secondary bile acids were associated both with increased TMAO levels and NASH.ConclusionsIn obese patients, circulating TMAO levels were associated with NASH mainly in the presence of T2D. Functional studies are required to evaluate the role of insulin resistance and T2D in this association, both highly prevalent in NASH patients.
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- 2021
39. Gluon propagator and three-gluon vertex with dynamical quarks
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Aguilar, A. C., De Soto, F., Ferreira, M. N., Papavassiliou, J., Rodríguez-Quintero, J., and Zafeiropoulos, S.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We present a detailed analysis of the kinetic and mass terms associated with the Landau gauge gluon propagator in the presence of dynamical quarks, and a comprehensive dynamical study of certain special kinematic limits of the three-gluon vertex. Our approach capitalizes on results from recent lattice simulations with (2+1) domain wall fermions, a novel nonlinear treatment of the gluon mass equation, and the nonperturbative reconstruction of the longitudinal three-gluon vertex from its fundamental Slavnov-Taylor identities. Particular emphasis is placed on the persistence of the suppression displayed by certain combinations of the vertex form factors at intermediate and low momenta, already known from numerous pure Yang-Mills studies. One of our central findings is that the inclusion of dynamical quarks moderates the intensity of this phenomenon only mildly, leaving the asymptotic low-momentum behavior unaltered, but displaces the characteristic "zero crossing" deeper into the infrared region. In addition, the effect of the three-gluon vertex is explored at the level of the renormalization-group invariant combination corresponding to the effective gauge coupling, whose size is considerably reduced with respect to its counterpart obtained from the ghost-gluon vertex. The main upshot of the above considerations is the further confirmation of the tightly interwoven dynamics between the two- and three-point sectors of QCD., Comment: 32 pages, 10 figures
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- 2019
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40. Gluon mass scale through nonlinearities and vertex interplay
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Aguilar, A. C., Ferreira, M. N., Figueiredo, C. T., and Papavassiliou, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We present a novel analysis of the gluon gap equation, where its full nonlinear structure is duly taken into account. In particular, while in previous treatments the linearization of this homogeneous integral equation introduced an indeterminacy in the scale of the corresponding mass, the current approach determines it uniquely, once the value of the gauge coupling at a given renormalization point is used as input. A crucial ingredient for this construction is the "kinetic term" of the gluon propagator, whose form is not obtained from the complicated equation governing its evolution, but is rather approximated by suitable initial {\it Ans\"atze}, which are subsequently improved by means of a systematic iterative procedure. The multiplicative renormalization of the central equation is carried out following an approximate method, which is extensively employed in the studies of the standard quark gap equation. This approach amounts to the effective substitution of the vertex renormalization constants by kinematically simplified form factors of the three- and four-gluon vertices. The resulting numerical interplay, exemplified by the infrared suppression of the three-gluon vertex and the mild enhancement of the four-gluon vertex, is instrumental for obtaining positive-definite and monotonically decreasing running gluon masses. The resulting gluon propagators, put together from the gluon masses and kinetic terms obtained with this method, match rather accurately the data obtained from large-volume lattice simulations., Comment: 37 pages, 11 figures
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- 2019
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41. Pseudoscalar glueball mass: a window on three-gluon interactions
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Souza, E. V., Ferreira, M. N., Aguilar, A. C., Papavassiliou, J., Roberts, C. D., and Xu, S. -S.
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Nuclear Theory ,High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,Nuclear Experiment - Abstract
In pure-glue QCD, gluon-gluon scattering in the $J^{PC}=0^{-+}$ channel is described by a very simple equation, especially if one considers just the leading contribution to the scattering kernel. Of all components in this kernel, only the three-gluon vertex, $V_{\mu\nu\rho}$, is poorly constrained by contemporary analyses; hence, calculations of $0^{-+}$ glueball properties serve as a clear window onto the character and form of $V_{\mu\nu\rho}$. This is important given that many modern calculations of $V_{\mu\nu\rho}$ predict the appearance of an infrared suppression in the scalar function which comes to modulate the bare vertex after the nonperturbative resummation of interactions. Such behaviour is a peculiar prediction; but we find that such suppression is essential if one is to achieve agreement with lattice-QCD predictions for the $0^{-+}$ glueball mass. It is likely, therefore, that this novel feature of $V_{\mu\nu\rho}$ is real and has observable implications for the spectrum, decays and interactions of all QCD bound-states., Comment: 6 pages, 4 figures. To appear in Eur. Phys. J. A - Letter
- Published
- 2019
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42. Pion and Kaon Structure at the Electron-Ion Collider
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Aguilar, Arlene C., Ahmed, Zafir, Aidala, Christine, Ali, Salina, Andrieux, Vincent, Arrington, John, Bashir, Adnan, Berdnikov, Vladimir, Binosi, Daniele, Chang, Lei, Chen, Chen, Chen, Muyang, de Melo, João Pacheco B. C., Diefenthaler, Markus, Ding, Minghui, Ent, Rolf, Frederico, Tobias, Gao, Fei, Gothe, Ralf W., Hattawy, Mohammad, Hobbs, Timothy J., Horn, Tanja, Huber, Garth M., Jia, Shaoyang, Keppel, Cynthia, Krein, Gastão, Lin, Huey-Wen, Mezrag, Cédric, Mokeev, Victor, Montgomery, Rachel, Moutarde, Hervé, Nadolsky, Pavel, Papavassiliou, Joannis, Park, Kijun, Pegg, Ian L., Peng, Jen-Chieh, Platchkov, Stephane, Qin, Si-Xue, Raya, Khépani, Reimer, Paul, Richards, David G., Roberts, Craig D., Rodríguez-Quintero, Jose, Sato, Nobuo, Schmidt, Sebastian M., Segovia, Jorge, Tadepalli, Arun, Trotta, Richard, Ye, Zhihong, Yoshida, Rikutaro, and Xu, Shu-Sheng
- Subjects
Nuclear Experiment ,High Energy Physics - Experiment ,High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
Understanding the origin and dynamics of hadron structure and in turn that of atomic nuclei is a central goal of nuclear physics. This challenge entails the questions of how does the roughly 1 GeV mass-scale that characterizes atomic nuclei appear; why does it have the observed value; and, enigmatically, why are the composite Nambu-Goldstone (NG) bosons in quantum chromodynamics (QCD) abnormally light in comparison? In this perspective, we provide an analysis of the mass budget of the pion and proton in QCD; discuss the special role of the kaon, which lies near the boundary between dominance of strong and Higgs mass-generation mechanisms; and explain the need for a coherent effort in QCD phenomenology and continuum calculations, in exa-scale computing as provided by lattice QCD, and in experiments to make progress in understanding the origins of hadron masses and the distribution of that mass within them. We compare the unique capabilities foreseen at the electron-ion collider (EIC) with those at the hadron-electron ring accelerator (HERA), the only previous electron-proton collider; and describe five key experimental measurements, enabled by the EIC and aimed at delivering fundamental insights that will generate concrete answers to the questions of how mass and structure arise in the pion and kaon, the Standard Model's NG modes, whose surprisingly low mass is critical to the evolution of our Universe., Comment: 16 pages, 12 figures, to appear in the European Physical Journal A - "Hadrons and Nuclei"
- Published
- 2019
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43. Nonperturbative Ball-Chiu construction of the three-gluon vertex
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Aguilar, A. C., Ferreira, M. N., Figueiredo, C. T., and Papavassiliou, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We present the detailed derivation of the longitudinal part of the three-gluon vertex from the Slavnov-Taylor identities that it satisfies, by means of a nonperturbative implementation of the Ball-Chiu construction; the latter, in its original form, involves the inverse gluon propagator, the ghost dressing function, and certain form factors of the ghost-gluon kernel. The main conceptual subtlety that renders this endeavor nontrivial is the infrared finiteness of the gluon propagator, and the resulting need to separate the vertex into two pieces, one that is intimately connected with the emergence of a gluonic mass scale, and one that satisfies the original set of Slavnov-Taylor identities, but with the inverse gluon propagator replaced by its "kinetic" term. The longitudinal form factors obtained by this construction are presented for arbitrary Euclidean momenta, as well as special kinematic configurations, parametrized by a single momentum. A particularly preeminent feature of the components comprising the tree-level vertex is their considerable suppression for momenta below 1 GeV, and the appearance of the characteristic "zero-crossing" in the vicinity of 100-200 MeV. Special combinations of the form factors derived with this method are compared with the results of recent large-volume lattice simulations as well as Schwinger-Dyson equations, and good overall agreement is found. A variety of issues related to the distribution of the pole terms responsible for the gluon mass generation are discussed in detail, and their impact on the structure of the transverse parts is elucidated. In addition, a brief account of several theoretical and phenomenological possibilities involving these newly acquired results is presented., Comment: 55 pages, 18 figures
- Published
- 2019
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44. Modified Sialic Acids on Mucus and Erythrocytes Inhibit Influenza A Virus Hemagglutinin and Neuraminidase Functions
- Author
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Barnard, Karen N, Alford-Lawrence, Brynn K, Buchholz, David W, Wasik, Brian R, LaClair, Justin R, Yu, Hai, Honce, Rebekah, Ruhl, Stefan, Pajic, Petar, Daugherity, Erin K, Chen, Xi, Schultz-Cherry, Stacey L, Aguilar, Hector C, Varki, Ajit, and Parrish, Colin R
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Biological Sciences ,Emerging Infectious Diseases ,Influenza ,Biodefense ,Infectious Diseases ,Pneumonia & Influenza ,2.1 Biological and endogenous factors ,A549 Cells ,Animals ,Dogs ,Erythrocytes ,Female ,Hemagglutinin Glycoproteins ,Influenza Virus ,Hemagglutinins ,Humans ,Influenza A virus ,Influenza ,Human ,Madin Darby Canine Kidney Cells ,Male ,Mice ,Mixed Function Oxygenases ,Mucus ,N-Acetylneuraminic Acid ,Neuraminidase ,Orthomyxoviridae ,Receptors ,Virus ,Saliva ,influenza ,mucus ,sialic acids ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Virology ,Agricultural ,veterinary and food sciences ,Biological sciences ,Biomedical and clinical sciences - Abstract
Sialic acids (Sia) are the primary receptors for influenza viruses and are widely displayed on cell surfaces and in secreted mucus. Sia may be present in variant forms that include O-acetyl modifications at C-4, C-7, C-8, and C-9 positions and N-acetyl or N-glycolyl at C-5. They can also vary in their linkages, including α2-3 or α2-6 linkages. Here, we analyze the distribution of modified Sia in cells and tissues of wild-type mice or in mice lacking CMP-N-acetylneuraminic acid hydroxylase (CMAH) enzyme, which synthesizes N-glycolyl (Neu5Gc) modifications. We also examined the variation of Sia forms on erythrocytes and in saliva from different animals. To determine the effect of Sia modifications on influenza A virus (IAV) infection, we tested for effects on hemagglutinin (HA) binding and neuraminidase (NA) cleavage. We confirmed that 9-O-acetyl, 7,9-O-acetyl, 4-O-acetyl, and Neu5Gc modifications are widely but variably expressed in mouse tissues, with the highest levels detected in the respiratory and gastrointestinal (GI) tracts. Secreted mucins in saliva and surface proteins of erythrocytes showed a high degree of variability in display of modified Sia between different species. IAV HAs from different virus strains showed consistently reduced binding to both Neu5Gc- and O-acetyl-modified Sia; however, while IAV NAs were inhibited by Neu5Gc and O-acetyl modifications, there was significant variability between NA types. The modifications of Sia in mucus may therefore have potent effects on the functions of IAV and may affect both pathogens and the normal flora of different mucosal sites.IMPORTANCE Sialic acids (Sia) are involved in numerous different cellular functions and are receptors for many pathogens. Sia come in chemically modified forms, but we lack a clear understanding of how they alter interactions with microbes. Here, we examine the expression of modified Sia in mouse tissues, on secreted mucus in saliva, and on erythrocytes, including those from IAV host species and animals used in IAV research. These Sia forms varied considerably among different animals, and their inhibitory effects on IAV NA and HA activities and on bacterial sialidases (neuraminidases) suggest a host-variable protective role in secreted mucus.
- Published
- 2020
45. Zika virus spreads through infection of lymph node-resident macrophages
- Author
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Reynoso, Glennys V., Gordon, David N., Kalia, Anurag, Aguilar, Cynthia C., Malo, Courtney S., Aleshnick, Maya, Dowd, Kimberly A., Cherry, Christian R., Shannon, John P., Vrba, Sophia M., Holmes, Autumn C., Alippe, Yael, Maciejewski, Sonia, Asano, Kenichi, Diamond, Michael S., Pierson, Theodore C., and Hickman, Heather D.
- Published
- 2023
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46. Nonperturbative structure of the ghost-gluon kernel
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Aguilar, A. C., Ferreira, M. N., Figueiredo, C. T., and Papavassiliou, J.
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
The ghost-gluon scattering kernel is a special correlation function that is intimately connected with two fundamental vertices of the gauge sector of QCD: the ghost-gluon vertex, which may be obtained from it through suitable contraction, and the three-gluon vertex, whose Slavnov-Taylor identity contains that kernel as one of its main ingredients. In this work we present a detailed nonperturbative study of the five form factors comprising it, using as starting point the `one-loop dressed' approximation of the dynamical equations governing their evolution. The analysis is carried out for arbitrary Euclidean momenta, and makes extensive use of the gluon propagator and the ghost dressing function, whose infrared behavior has been firmly established from a multitude of continuum studies and large-volume lattice simulations. In addition, special Ans\"atze are employed for the vertices entering in the relevant equations, and their impact on the results is scrutinized in detail. Quite interestingly, the veracity of the approximations employed may be quantitatively tested by appealing to an exact relation, which fixes the value of a special combination of the form factors under construction. The results obtained furnish the two form factors of the ghost-gluon vertex for arbitrary momenta, and, more importantly, pave the way towards the nonperturbative generalization of the Ball-Chiu construction for the longitudinal part of the three-gluon vertex., Comment: 47 pages, 16 figures, expanded version matching the published one
- Published
- 2018
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47. Fractal continuum model for the adsorption-diffusion process
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Herrera-Hernández, E. C., Aguilar-Madera, C. G., Ocampo-Perez, R., Espinosa-Paredes, G., and Núñez-López, M.
- Subjects
Condensed Matter - Soft Condensed Matter ,Physics - Chemical Physics - Abstract
In this work, we present a mathematical model to describe the adsorption-diffusion process on fractal porous materials. This model is based on the fractal continuum approach and considers the scale-invariant properties of the surface and volume of adsorbent particles, which are well-represented by their fractal dimensions. The method of lines was used to solve the nonlinear fractal model, and the numerical predictions were compared with experimental data to determine the fractal dimensions through an optimization algorithm. The intraparticle mass flux and the mean square displacement dynamics as a function of fractal dimensions were analyzed. The results suggest that they can be potentially used to characterize the intraparticle mass transport processes. The fractal model demonstrated to be able to predict adsorption-diffusion experiments and jointly can be used to estimate fractal parameters of porous adsorbents.
- Published
- 2018
48. Effects of the ghost sector in gluon mass dynamics
- Author
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Aguilar, A. C. and Figueiredo, C. T.
- Subjects
High Energy Physics - Phenomenology - Abstract
In this work, we investigate the effects of the ghost sector on the dynamical mass generation for the gauge boson of a pure Yang-Mills theory. The generation of a dynamical mass for the gluon is realized by the Schwinger mechanism, which is triggered by the existence of longitudinally coupled massless poles in the fundamental vertices of the theory. The appearance of such poles occurs by purely dynamical reasons and is governed by a set of Bethe-Salpeter equations. In previous studies, only the presence of massless poles in the background-gauge three-gluon vertex was considered. Here, we include the possibility for such poles to appear also in the corresponding ghost-gluon vertex. Then, we solve the resulting Bethe-Salpeter system, which reveals that the contribution associated with the poles of the ghost-gluon vertex is suppressed with respect to those originating from the three-gluon vertex., Comment: 4 pages, 3 figures. Poster presented at the XIV International Workshop on Hadron Physics, Florianopolis, Brazil, 18-23 March 2018
- Published
- 2018
49. Quark mass generation with Schwinger-Dyson equations
- Author
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Aguilar, A. C. and Ferreira, M. N.
- Subjects
High Energy Physics - Phenomenology - Abstract
In this talk, we review some of the current efforts to understand the phenomenon of chiral symmetry breaking and the generation of a dynamical quark mass. To do that, we will use the standard framework of the Schwinger-Dyson equations. The key ingredient in this analysis is the quark-gluon vertex, whose non-transverse part may be determined exactly from the nonlinear Slavnov-Taylor identity that it satisfies. The resulting expressions for the form factors of this vertex involve not only the quark propagator, but also the ghost dressing function and the quark-ghost kernel. Solving the coupled system of integral equations formed by the quark propagator and the four form factors of the scattering kernel, we carry out a detailed study of the impact of the quark gluon vertex on the gap equation and the quark masses generated from it, putting particular emphasis on the contributions directly related with the ghost sector of the theory, and especially the quark-ghost kernel. Particular attention is dedicated on the way that the correct renormalization group behavior of the dynamical quark mass is recovered, and in the extraction of the phenomenological parameters such as the pion decay constant., Comment: 7 pages, 5 figures. Invited talk presented at the XIV International Workshop on Hadron Physics, Florian\'opolis, Brazil, 18-23 March 2018
- Published
- 2018
50. Quark gap equation with non-abelian Ball-Chiu vertex
- Author
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Aguilar, A. C., Cardona, J. C., Ferreira, M. N., and Papavassiliou, J.
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Lattice - Abstract
The full quark-gluon vertex is a crucial ingredient for the dynamical generation of a constituent quark mass from the standard quark gap equation, and its non-transverse part may be determined exactly from the nonlinear Slavnov-Taylor identity that it satisfies. The resulting expression involves not only the quark propagator, but also the ghost dressing function and the quark-ghost kernel, and constitutes the non-abelian extension of the so-called "Ball-Chiu vertex", known from QED. In the present work we carry out a detailed study of the impact of this vertex on the gap equation and the quark masses generated from it, putting particular emphasis on the contributions directly related with the ghost sector of the theory, and especially the quark-ghost kernel. In particular, we set up and solve the coupled system of six equations that determine the four form factors of the latter kernel and the two typical Dirac structures composing the quark propagator. Due to the incomplete implementation of the multiplicative renormalizability at the level of the gap equation, the correct anomalous dimension of the quark mass is recovered through the inclusion of a certain function, whose ultraviolet behavior is fixed, but its infrared completion is unknown; three particular Ans\"atze for this function are considered, and their effect on the quark mass and the pion decay constant is explored. The main results of this study indicate that the numerical impact of the quark-ghost kernel is considerable; the transition from a tree-level kernel to the one computed here leads to a $20\%$ increase in the value of the quark mass at the origin. Particularly interesting is the contribution of the fourth Ball-Chiu form factor, which, contrary to the abelian case, is nonvanishing, and accounts for $10\%$ of the total constituent quark mass., Comment: 30 pages, 9 figures, expanded version matching the published one
- Published
- 2018
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